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James R. Fuchs, Ph.D. - Publications

Affiliations: 
Pennsylvania State University, State College, PA, United States 
 2007- Medicinal Chemistry and Pharmacognosy Ohio State University, Columbus, Columbus, OH 
Area:
Natural products synthesis
Website:
http://pharmacy.osu.edu/faculty-staff/users/fuchs42
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39 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Dinh T, Tber Z, Rey JS, Mengshetti S, Annamalai AS, Haney R, Briganti L, Amblard F, Fuchs JR, Cherepanov P, Kim K, Schinazi RF, Perilla JR, Kim B, Kvaratskhelia M. The structural and mechanistic bases for the viral resistance to allosteric HIV-1 integrase inhibitor pirmitegravir. Biorxiv : the Preprint Server For Biology. PMID 38328097 DOI: 10.1101/2024.01.26.577387  0.377
2022 Bester SM, Adu-Ampratwum D, Annamalai AS, Wei G, Briganti L, Murphy BC, Haney R, Fuchs JR, Kvaratskhelia M. Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir. Mbio. e0180422. PMID 36190128 DOI: 10.1128/mbio.01804-22  0.304
2022 Adu-Ampratwum D, Pan Y, Koneru PC, Antwi J, Hoyte AC, Kessl J, Griffin PR, Kvaratskhelia M, Fuchs JR, Larue RC. Identification and Optimization of a Novel HIV-1 Integrase Inhibitor. Acs Omega. 7: 4482-4491. PMID 35155940 DOI: 10.1021/acsomega.1c06378  0.423
2021 Amrine CSM, Huntsman AC, Doyle MG, Burdette JE, Pearce CJ, Fuchs JR, Oberlies NH. Semisynthetic Derivatives of the Verticillin Class of Natural Products through Acylation of the C11 Hydroxy Group. Acs Medicinal Chemistry Letters. 12: 625-630. PMID 33859802 DOI: 10.1021/acsmedchemlett.1c00024  0.301
2020 Bester SM, Wei G, Zhao H, Adu-Ampratwum D, Iqbal N, Courouble VV, Francis AC, Annamalai AS, Singh PK, Shkriabai N, Van Blerkom P, Morrison J, Poeschla EM, Engelman AN, Melikyan GB, ... ... Fuchs JR, et al. Structural and mechanistic bases for a potent HIV-1 capsid inhibitor. Science (New York, N.Y.). 370: 360-364. PMID 33060363 DOI: 10.1126/science.abb4808  0.372
2019 Koneru PC, Francis AC, Deng N, Rebensburg SV, Hoyte AC, Lindenberger J, Adu-Ampratwum D, Larue RC, Wempe MF, Engelman AN, Lyumkis D, Fuchs JR, Levy RM, Melikyan GB, Kvaratskhelia M. HIV-1 integrase tetramers are the antiviral target of pyridine-based allosteric integrase inhibitors. Elife. 8. PMID 31120420 DOI: 10.7554/Elife.46344  0.373
2019 Wilson TA, Koneru PC, Rebensburg SV, Lindenberger JJ, Kobe MJ, Cockroft NT, Adu-Ampratwum D, Larue RC, Kvaratskhelia M, Fuchs JR. An Isoquinoline Scaffold as a Novel Class of Allosteric HIV-1 Integrase Inhibitors. Acs Medicinal Chemistry Letters. 10: 215-220. PMID 30783506 DOI: 10.1021/acsmedchemlett.8b00633  0.445
2018 Young AN, Herrera D, Huntsman AC, Korkmaz MA, Lantvit DD, Mazumder S, Kolli S, Coss CC, King S, Wang H, Swanson SM, Kinghorn AD, Zhang X, Phelps MA, Aldrich LN, ... Fuchs JR, et al. Phyllanthusmin derivatives induce apoptosis and reduce tumor burden in high grade serous ovarian cancer by late-stage autophagy inhibition. Molecular Cancer Therapeutics. PMID 30018048 DOI: 10.1158/1535-7163.Mct-17-1195  0.303
2018 Woodard JL, Huntsman AC, Patel PA, Chai HB, Kanagasabai R, Karmahapatra S, Young AN, Ren Y, Cole MS, Herrera D, Yalowich JC, Kinghorn AD, Burdette JE, Fuchs JR. Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignan lactones. Bioorganic & Medicinal Chemistry. PMID 29656990 DOI: 10.1016/J.Bmc.2018.03.033  0.75
2017 Hoyte AC, Jamin AV, Koneru PC, Kobe MJ, Larue RC, Fuchs JR, Engelman AN, Kvaratskhelia M. Resistance to pyridine-based inhibitor KF116 reveals an unexpected role of integrase in HIV-1 Gag-Pol polyprotein proteolytic processing. The Journal of Biological Chemistry. 292: 19814-19825. PMID 28972144 DOI: 10.1074/Jbc.M117.816645  0.373
2016 Patel D, Antwi J, Koneru PC, Serrao E, Forli S, Kessl JJ, Feng L, Deng N, Levy RM, Fuchs JR, Olson AJ, Engelman AN, Bauman JD, Kvaratskhelia M, Arnold E. A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain. The Journal of Biological Chemistry. 291: 23569-23577. PMID 27645997 DOI: 10.1074/Jbc.M116.753384  0.451
2016 Patel PA, Kvaratskhelia N, Mansour Y, Antwi J, Feng L, Koneru P, Kobe MJ, Jena N, Shi G, Mohamed MS, Li C, Kessl JJ, Fuchs JR. Indole-based allosteric inhibitors of HIV-1 integrase. Bioorganic & Medicinal Chemistry Letters. PMID 27568085 DOI: 10.1016/J.Bmcl.2016.08.037  0.773
2016 Agharbaoui FE, Hoyte AC, Ferro S, Gitto R, Buemi MR, Fuchs JR, Kvaratskhelia M, De Luca L. Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase. European Journal of Medicinal Chemistry. 123: 673-683. PMID 27517812 DOI: 10.1016/j.ejmech.2016.07.077  0.429
2016 Deng N, Hoyte A, Mansour YE, Mohamed MS, Fuchs JR, Engelman AN, Kvaratskhelia M, Levy R. Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies. Protein Science : a Publication of the Protein Society. 25: 1911-1917. PMID 27503276 DOI: 10.1002/Pro.2997  0.323
2016 Feng L, Dharmarajan V, Serrao E, Hoyte A, Larue RC, Slaughter A, Sharma A, Plumb MR, Kessl JJ, Fuchs JR, Bushman FD, Engelman AN, Griffin PR, Kvaratskhelia M. The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency. Acs Chemical Biology. 11: 1313-21. PMID 26910179 DOI: 10.1021/Acschembio.6B00167  0.389
2014 Slaughter A, Jurado KA, Deng N, Feng L, Kessl JJ, Shkriabai N, Larue RC, Fadel HJ, Patel PA, Jena N, Fuchs JR, Poeschla E, Levy RM, Engelman A, Kvaratskhelia M. The mechanism of H171T resistance reveals the importance of Nδ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase. Retrovirology. 11: 100. PMID 25421939 DOI: 10.1186/S12977-014-0100-1  0.762
2014 Shkriabai N, Dharmarajan V, Slaughter A, Kessl JJ, Larue RC, Feng L, Fuchs JR, Griffin PR, Kvaratskhelia M. A critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase. The Journal of Biological Chemistry. 289: 26430-40. PMID 25118283 DOI: 10.1074/jbc.M114.589572  0.366
2014 Fadel HJ, Morrison JH, Saenz DT, Fuchs JR, Kvaratskhelia M, Ekker SC, Poeschla EM. TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism. Journal of Virology. 88: 9704-17. PMID 24942577 DOI: 10.1128/Jvi.01397-14  0.357
2014 Kim TD, Fuchs JR, Schwartz E, Abdelhamid D, Etter J, Berry WL, Li C, Ihnat MA, Li PK, Janknecht R. Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors. American Journal of Translational Research. 6: 236-47. PMID 24936217  0.706
2014 Sharma A, Slaughter A, Jena N, Feng L, Kessl JJ, Fadel HJ, Malani N, Male F, Wu L, Poeschla E, Bushman FD, Fuchs JR, Kvaratskhelia M. A new class of multimerization selective inhibitors of HIV-1 integrase. Plos Pathogens. 10: e1004171. PMID 24874515 DOI: 10.1371/Journal.Ppat.1004171  0.53
2013 Feng L, Sharma A, Slaughter A, Jena N, Koh Y, Shkriabai N, Larue RC, Patel PA, Mitsuya H, Kessl JJ, Engelman A, Fuchs JR, Kvaratskhelia M. The A128T resistance mutation reveals aberrant protein multimerization as the primary mechanism of action of allosteric HIV-1 integrase inhibitors. The Journal of Biological Chemistry. 288: 15813-20. PMID 23615903 DOI: 10.1074/Jbc.M112.443390  0.77
2013 Jurado KA, Wang H, Slaughter A, Feng L, Kessl JJ, Koh Y, Wang W, Ballandras-Colas A, Patel PA, Fuchs JR, Kvaratskhelia M, Engelman A. Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation. Proceedings of the National Academy of Sciences of the United States of America. 110: 8690-5. PMID 23610442 DOI: 10.1073/Pnas.1300703110  0.762
2013 Mace TA, Ameen Z, Collins A, Wojcik S, Mair M, Young GS, Fuchs JR, Eubank TD, Frankel WL, Bekaii-Saab T, Bloomston M, Lesinski GB. Pancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner. Cancer Research. 73: 3007-18. PMID 23514705 DOI: 10.1158/0008-5472.Can-12-4601  0.312
2012 Wang H, Jurado KA, Wu X, Shun MC, Li X, Ferris AL, Smith SJ, Patel PA, Fuchs JR, Cherepanov P, Kvaratskhelia M, Hughes SH, Engelman A. HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor. Nucleic Acids Research. 40: 11518-30. PMID 23042676 DOI: 10.1093/Nar/Gks913  0.754
2012 Bill MA, Nicholas C, Mace TA, Etter JP, Li C, Schwartz EB, Fuchs JR, Young GS, Lin L, Lin J, He L, Phelps M, Li PK, Lesinski GB. Structurally modified curcumin analogs inhibit STAT3 phosphorylation and promote apoptosis of human renal cell carcinoma and melanoma cell lines. Plos One. 7: e40724. PMID 22899991 DOI: 10.1371/Journal.Pone.0040724  0.733
2012 Kessl JJ, Jena N, Koh Y, Taskent-Sezgin H, Slaughter A, Feng L, de Silva S, Wu L, Le Grice SF, Engelman A, Fuchs JR, Kvaratskhelia M. Multimode, cooperative mechanism of action of allosteric HIV-1 integrase inhibitors. The Journal of Biological Chemistry. 287: 16801-11. PMID 22437836 DOI: 10.1074/Jbc.M112.354373  0.506
2011 Lin L, Fuchs J, Li C, Olson V, Bekaii-Saab T, Lin J. STAT3 signaling pathway is necessary for cell survival and tumorsphere forming capacity in ALDH⁺/CD133⁺ stem cell-like human colon cancer cells. Biochemical and Biophysical Research Communications. 416: 246-51. PMID 22074823 DOI: 10.1016/J.Bbrc.2011.10.112  0.33
2011 Fossey SL, Bear MD, Lin J, Li C, Schwartz EB, Li PK, Fuchs JR, Fenger J, Kisseberth WC, London CA. The novel curcumin analog FLLL32 decreases STAT3 DNA binding activity and expression, and induces apoptosis in osteosarcoma cell lines. Bmc Cancer. 11: 112. PMID 21443800 DOI: 10.1186/1471-2407-11-112  0.306
2010 Lin L, Deangelis S, Foust E, Fuchs J, Li C, Li PK, Schwartz EB, Lesinski GB, Benson D, Lü J, Hoyt D, Lin J. A novel small molecule inhibits STAT3 phosphorylation and DNA binding activity and exhibits potent growth suppressive activity in human cancer cells. Molecular Cancer. 9: 217. PMID 20712901 DOI: 10.1186/1476-4598-9-217  0.372
2010 Bill MA, Fuchs JR, Li C, Yui J, Bakan C, Benson DM, Schwartz EB, Abdelhamid D, Lin J, Hoyt DG, Fossey SL, Young GS, Carson WE, Li PK, Lesinski GB. The small molecule curcumin analog FLLL32 induces apoptosis in melanoma cells via STAT3 inhibition and retains the cellular response to cytokines with anti-tumor activity. Molecular Cancer. 9: 165. PMID 20576164 DOI: 10.1186/1476-4598-9-165  0.387
2010 Lin L, Hutzen B, Zuo M, Ball S, Deangelis S, Foust E, Pandit B, Ihnat MA, Shenoy SS, Kulp S, Li PK, Li C, Fuchs J, Lin J. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Research. 70: 2445-54. PMID 20215512 DOI: 10.1158/0008-5472.Can-09-2468  0.409
2009 Bill MA, Bakan C, Benson DM, Fuchs J, Young G, Lesinski GB. Curcumin induces proapoptotic effects against human melanoma cells and modulates the cellular response to immunotherapeutic cytokines. Molecular Cancer Therapeutics. 8: 2726-35. PMID 19723881 DOI: 10.1158/1535-7163.Mct-09-0377  0.315
2009 Fuchs JR, Pandit B, Bhasin D, Etter JP, Regan N, Abdelhamid D, Li C, Lin J, Li PK. Structure-activity relationship studies of curcumin analogues. Bioorganic & Medicinal Chemistry Letters. 19: 2065-9. PMID 19249204 DOI: 10.1016/J.Bmcl.2009.01.104  0.724
2009 Liu Z, Liu S, Xie Z, Pavlovicz RE, Wu J, Chen P, Aimiuwu J, Pang J, Bhasin D, Neviani P, Fuchs JR, Plass C, Li PK, Li C, Huang TH, et al. Modulation of DNA methylation by a sesquiterpene lactone parthenolide. The Journal of Pharmacology and Experimental Therapeutics. 329: 505-14. PMID 19201992 DOI: 10.1124/Jpet.108.147934  0.366
2006 Elliott GI, Fuchs JR, Blagg BS, Ishikawa H, Tao H, Yuan ZQ, Boger DL. Intramolecular diels-alder/1,3-dipolar cycloaddition cascade of 1,3,4-oxadiazoles. Journal of the American Chemical Society. 128: 10589-95. PMID 16895427 DOI: 10.1021/Ja0612549  0.584
2005 Fuchs JR, Funk RL. Indol-2-one intermediates: mechanistic evidence and synthetic utility. Total syntheses of (+/-)-flustramines A and C. Organic Letters. 7: 677-80. PMID 15704923 DOI: 10.1021/Ol047532V  0.59
2004 Fuchs JR, Funk RL. Total synthesis of (+/-)-perophoramidine. Journal of the American Chemical Society. 126: 5068-9. PMID 15099080 DOI: 10.1021/Ja049569G  0.582
2001 Fuchs JR, Funk RL. Total synthesis of (+/-)-lennoxamine and (+/-)-aphanorphine by intramolecular electrophilic aromatic substitution reactions of 2-amidoacroleins. Organic Letters. 3: 3923-5. PMID 11720570 DOI: 10.1021/Ol016795B  0.6
2001 Fuchs JR, Funk RL. Intramolecular electrophilic aromatic substitution reactions of 2-amidoacroleins: a new method for the preparation of tetrahydroisoquinolines, tetrahydro-3-benzazepines, and hexahydro-3-benzazocines. Organic Letters. 3: 3349-51. PMID 11594831 DOI: 10.1021/Ol016592N  0.587
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