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Daniel R. Southworth, Ph.D. - Publications

Affiliations: 
2004 Johns Hopkins University, Baltimore, MD 
Area:
translation of the genetic code
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48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Felker D, Lee K, Pospiech TH, Morishima Y, Zhang H, Lau M, Southworth D, Osawa Y. Mapping interactions of calmodulin and neuronal NO synthase by crosslinking and mass spectrometry. The Journal of Biological Chemistry. 105464. PMID 37979917 DOI: 10.1016/j.jbc.2023.105464  0.683
2023 Nadel CM, Thwin AC, Callahan M, Lee K, Connelly E, Craik CS, Southworth DR, Gestwicki JE. The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT). Journal of Molecular Biology. 168026. PMID 37330289 DOI: 10.1016/j.jmb.2023.168026  0.678
2023 Braxton JR, Shao H, Tse E, Gestwicki JE, Southworth DR. Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly. Biorxiv : the Preprint Server For Biology. PMID 37293102 DOI: 10.1101/2023.05.15.540872  0.347
2022 Cupo RR, Rizo AN, Braun GA, Tse E, Chuang E, Gupta K, Southworth DR, Shorter J. Unique structural features govern the activity of a human mitochondrial AAA+ disaggregase, Skd3. Cell Reports. 40: 111408. PMID 36170828 DOI: 10.1016/j.celrep.2022.111408  0.37
2021 Seraphim TV, Nano N, Cheung YWS, Aluksanasuwan S, Colleti C, Mao YQ, Bhandari V, Young G, Höll L, Phanse S, Gordiyenko Y, Southworth DR, Robinson CV, Thongboonkerd V, Gava LM, et al. Assembly principles of the human R2TP chaperone complex reveal the presence of R2T and R2P complexes. Structure (London, England : 1993). PMID 34492227 DOI: 10.1016/j.str.2021.08.002  0.322
2021 Lee K, Thwin AC, Nadel CM, Tse E, Gates SN, Gestwicki JE, Southworth DR. The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state. Molecular Cell. PMID 34380015 DOI: 10.1016/j.molcel.2021.07.023  0.731
2021 Verba K, Gupta M, Azumaya C, Moritz M, Pourmal S, Diallo A, Merz G, Jang G, Bouhaddou M, Fossati A, Brilot A, Diwanji D, Hernandez E, Herrera N, Kratochvil H, ... ... Southworth D, et al. CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. Research Square. PMID 34031651 DOI: 10.21203/rs.3.rs-515215/v1  0.342
2021 Gupta M, Azumaya CM, Moritz M, Pourmal S, Diallo A, Merz GE, Jang G, Bouhaddou M, Fossati A, Brilot AF, Diwanji D, Hernandez E, Herrera N, Kratochvil HT, Lam VL, ... ... Southworth DR, et al. CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. Biorxiv : the Preprint Server For Biology. PMID 34013269 DOI: 10.1101/2021.05.10.443524  0.342
2020 Lopez KE, Rizo AN, Tse E, Lin J, Scull NW, Thwin AC, Lucius AL, Shorter J, Southworth DR. Conformational plasticity of the ClpAP AAA+ protease couples protein unfolding and proteolysis. Nature Structural & Molecular Biology. PMID 32313240 DOI: 10.1038/S41594-020-0409-5  0.419
2019 Chen JJ, Nathaniel DL, Raghavan P, Nelson M, Tian R, Tse E, Hong JY, See SK, Mok SA, Hein MY, Southworth DR, Grinberg LT, Gestwicki JE, Leonetti MD, Kampmann M. Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation. The Journal of Biological Chemistry. PMID 31578281 DOI: 10.1074/Jbc.Ra119.009432  0.328
2019 Tariq A, Lin J, Jackrel ME, Hesketh CD, Carman PJ, Mack KL, Weitzman R, Gambogi C, Hernandez Murillo OA, Sweeny EA, Gurpinar E, Yokom AL, Gates SN, Yee K, Sudesh S, ... ... Southworth DR, et al. Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity. Cell Reports. 28: 2080-2095.e6. PMID 31433984 DOI: 10.1016/J.Celrep.2019.07.069  0.394
2019 Rizo AN, Lin J, Gates SN, Tse E, Bart SM, Castellano LM, DiMaio F, Shorter J, Southworth DR. Structural basis for substrate gripping and translocation by the ClpB AAA+ disaggregase. Nature Communications. 10: 2393. PMID 31160557 DOI: 10.1038/S41467-019-10150-Y  0.458
2019 Ruetz M, Campanello GC, McDevitt L, Yokom AL, Yadav PK, Watkins D, Rosenblatt DS, Ohi MD, Southworth DR, Banerjee R. Allosteric Regulation of Oligomerization by a B Trafficking G-Protein Is Corrupted in Methylmalonic Aciduria. Cell Chemical Biology. PMID 31056463 DOI: 10.1016/J.Chembiol.2019.03.014  0.371
2019 Shorter J, Southworth DR. Spiraling in Control: Structures and Mechanisms of the Hsp104 Disaggregase. Cold Spring Harbor Perspectives in Biology. PMID 30745294 DOI: 10.1101/Cshperspect.A034033  0.404
2019 Teixeira F, Tse E, Castro H, Makepeace KAT, Meinen BA, Borchers CH, Poole LB, Bardwell JC, Tomás AM, Southworth DR, Jakob U. Chaperone activation and client binding of a 2-cysteine peroxiredoxin. Nature Communications. 10: 659. PMID 30737390 DOI: 10.2210/Pdb6E0G/Pdb  0.465
2018 Freilich R, Betegon M, Tse E, Mok SA, Julien O, Agard DA, Southworth DR, Takeuchi K, Gestwicki JE. Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau. Nature Communications. 9: 4563. PMID 30385828 DOI: 10.1038/S41467-018-07012-4  0.431
2018 Yoo N, Dogra S, Meinen BA, Tse E, Haefliger J, Southworth DR, Gray MJ, Dahl JU, Jakob U. Polyphosphate Stabilizes Protein Unfolding Intermediates as Soluble Amyloid-like Oligomers. Journal of Molecular Biology. PMID 30130556 DOI: 10.1016/J.Jmb.2018.08.016  0.386
2018 Morishima Y, Mehta RK, Yoshimura M, Lau M, Southworth DR, Lawrence TS, Pratt WB, Nyati MK, Osawa Y. Chaperone Activity and Dimerization Properties of Hsp90α and Hsp90β in Glucocorticoid Receptor Activation by the Multiprotein Hsp90/Hsp70-Dependent Chaperone Machinery. Molecular Pharmacology. PMID 29941666 DOI: 10.1124/Mol.118.112516  0.396
2018 Zhang H, Yokom AL, Cheng S, Su M, Hollenberg PF, Southworth DR, Osawa Y. The full-length cytochrome P450 enzyme CYP102A1 dimerizes at its reductase domains and has flexible heme domains for efficient catalysis. The Journal of Biological Chemistry. PMID 29618513 DOI: 10.1074/Jbc.Ra117.000600  0.383
2017 Cesa LC, Shao H, Srinivasan SR, Tse E, Jain C, Zuiderweg ERP, Southworth DR, Mapp AK, Gestwicki JE. X-Linked Inhibitor of Apoptosis Protein (XIAP) is a Client of Heat Shock Protein 70 (Hsp70) and a Biomarker of its Inhibition. The Journal of Biological Chemistry. PMID 29255093 DOI: 10.1074/Jbc.Ra117.000634  0.375
2017 Campanello GC, Lofgren M, Yokom AL, Southworth DR, Banerjee R. Switch I-Dependent Allosteric Signaling In A G-Protein Chaperone-B12 Enzyme Complex. The Journal of Biological Chemistry. PMID 28882898 DOI: 10.1074/Jbc.M117.786095  0.451
2017 Gates SN, Yokom AL, Lin J, Jackrel ME, Rizo AN, Kendsersky NM, Buell CE, Sweeny EA, Mack KL, Chuang E, Torrente MP, Su M, Shorter J, Southworth DR. Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104. Science (New York, N.Y.). PMID 28619716 DOI: 10.1126/Science.Aan1052  0.446
2017 Read DF, Waller TJ, Tse E, Southworth DR, Engelke DR, Smaldino PJ. Aggregation of Mod5 is affected by tRNA binding with implications for tRNA gene-mediated silencing. Febs Letters. PMID 28303570 DOI: 10.1002/1873-3468.12627  0.399
2016 Rauch JN, Tse E, Freilich R, Mok SA, Makley LN, Southworth DR, Gestwicki JE. BAG3 is a modular, scaffolding protein that physically links heat shock protein 70 (Hsp70) to the small heat shock proteins. Journal of Molecular Biology. PMID 27884606 DOI: 10.1016/J.Jmb.2016.11.013  0.404
2016 Cremers CM, Knoefler D, Gates S, Martin N, Dahl JU, Lempart J, Xie L, Chapman MR, Galvan V, Southworth DR, Jakob U. Polyphosphate: A Conserved Modifier of Amyloidogenic Processes. Molecular Cell. PMID 27570072 DOI: 10.1016/J.Molcel.2016.07.016  0.308
2016 Yokom AL, Gates SN, Jackrel ME, Mack KL, Su M, Shorter J, Southworth DR. Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation. Nature Structural & Molecular Biology. PMID 27478928 DOI: 10.1038/Nsmb.3277  0.464
2016 Ewens CA, Su M, Zhao L, Nano N, Houry WA, Southworth DR. Architecture and Nucleotide-Dependent Conformational Changes of the Rvb1-Rvb2 AAA+ Complex Revealed by Cryoelectron Microscopy. Structure (London, England : 1993). PMID 27112599 DOI: 10.1016/J.Str.2016.03.018  0.436
2015 Assimon VA, Southworth DR, Gestwicki JE. Specific binding of tetratricopeptide repeat (TPR) proteins to heat shock protein 70 (Hsp70) and heat shock protein 90 (Hsp90) is regulated by affinity and phosphorylation. Biochemistry. PMID 26565746 DOI: 10.1021/Acs.Biochem.5B00801  0.456
2015 Rajagopal P, Tse E, Borst AJ, Delbecq SP, Shi L, Southworth DR, Klevit RE. A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress-related acidosis. Elife. 4. PMID 25962097 DOI: 10.7554/Elife.07304  0.39
2015 Teixeira F, Castro H, Cruz T, Tse E, Koldewey P, Southworth DR, Tomás AM, Jakob U. Mitochondrial peroxiredoxin functions as crucial chaperone reservoir in Leishmania infantum. Proceedings of the National Academy of Sciences of the United States of America. 112: E616-24. PMID 25646478 DOI: 10.1073/Pnas.1419682112  0.443
2014 Voth W, Schick M, Gates S, Li S, Vilardi F, Gostimskaya I, Southworth DR, Schwappach B, Jakob U. The protein targeting factor Get3 functions as ATP-independent chaperone under oxidative stress conditions. Molecular Cell. 56: 116-27. PMID 25242142 DOI: 10.1016/J.Molcel.2014.08.017  0.405
2014 Kirschke E, Goswami D, Southworth D, Griffin PR, Agard DA. Glucocorticoid receptor function regulated by coordinated action of the Hsp90 and Hsp70 chaperone cycles. Cell. 157: 1685-97. PMID 24949977 DOI: 10.1016/J.Cell.2014.04.038  0.4
2014 Yokom AL, Morishima Y, Lau M, Su M, Glukhova A, Osawa Y, Southworth DR. Architecture of the nitric-oxide synthase holoenzyme reveals large conformational changes and a calmodulin-driven release of the FMN domain. The Journal of Biological Chemistry. 289: 16855-65. PMID 24737326 DOI: 10.1074/Jbc.M114.564005  0.38
2014 Shukla S, Allam US, Ahsan A, Chen G, Krishnamurthy PM, Marsh K, Rumschlag M, Shankar S, Whitehead C, Schipper M, Basrur V, Southworth DR, Chinnaiyan AM, Rehemtulla A, Beer DG, et al. KRAS protein stability is regulated through SMURF2: UBCH5 complex-mediated β-TrCP1 degradation. Neoplasia (New York, N.Y.). 16: 115-28. PMID 24709419 DOI: 10.1593/Neo.14184  0.382
2014 Connarn JN, Assimon VA, Reed RA, Tse E, Southworth DR, Zuiderweg ER, Gestwicki JE, Sun D. The molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain. The Journal of Biological Chemistry. 289: 2908-17. PMID 24327656 DOI: 10.1074/Jbc.M113.519421  0.462
2013 Smith MC, Scaglione KM, Assimon VA, Patury S, Thompson AD, Dickey CA, Southworth DR, Paulson HL, Gestwicki JE, Zuiderweg ER. The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex. Biochemistry. 52: 5354-64. PMID 23865999 DOI: 10.1021/Bi4009209  0.424
2012 Cunningham CN, Southworth DR, Krukenberg KA, Agard DA. The conserved arginine 380 of Hsp90 is not a catalytic residue, but stabilizes the closed conformation required for ATP hydrolysis. Protein Science : a Publication of the Protein Society. 21: 1162-71. PMID 22653663 DOI: 10.1002/Pro.2103  0.487
2011 Southworth DR, Agard DA. Client-loading conformation of the Hsp90 molecular chaperone revealed in the cryo-EM structure of the human Hsp90:Hop complex. Molecular Cell. 42: 771-81. PMID 21700222 DOI: 10.1016/J.Molcel.2011.04.023  0.47
2009 Krukenberg KA, Böttcher UM, Southworth DR, Agard DA. Grp94, the endoplasmic reticulum Hsp90, has a similar solution conformation to cytosolic Hsp90 in the absence of nucleotide. Protein Science : a Publication of the Protein Society. 18: 1815-27. PMID 19554567 DOI: 10.1002/Pro.191  0.438
2009 Krukenberg KA, Southworth DR, Street TO, Agard DA. pH-dependent conformational changes in bacterial Hsp90 reveal a Grp94-like conformation at pH 6 that is highly active in suppression of citrate synthase aggregation. Journal of Molecular Biology. 390: 278-91. PMID 19427321 DOI: 10.1016/J.Jmb.2009.04.080  0.378
2008 Southworth DR, Agard DA. Species-dependent ensembles of conserved conformational states define the Hsp90 chaperone ATPase cycle. Molecular Cell. 32: 631-40. PMID 19061638 DOI: 10.1016/J.Molcel.2008.10.024  0.425
2007 Sharma D, Cukras AR, Rogers EJ, Southworth DR, Green R. Mutational analysis of S12 protein and implications for the accuracy of decoding by the ribosome. Journal of Molecular Biology. 374: 1065-76. PMID 17967466 DOI: 10.1016/J.Jmb.2007.10.003  0.689
2006 Shiau AK, Harris SF, Southworth DR, Agard DA. Structural Analysis of E. coli hsp90 reveals dramatic nucleotide-dependent conformational rearrangements. Cell. 127: 329-40. PMID 17055434 DOI: 10.1016/J.Cell.2006.09.027  0.456
2004 Sharma D, Southworth DR, Green R. EF-G-independent reactivity of a pre-translocation-state ribosome complex with the aminoacyl tRNA substrate puromycin supports an intermediate (hybrid) state of tRNA binding. Rna (New York, N.Y.). 10: 102-13. PMID 14681589 DOI: 10.1261/Rna.5148704  0.631
2003 Maki JA, Southworth DR, Culver GM. Demonstration of the role of the DnaK chaperone system in assembly of 30S ribosomal subunits using a purified in vitro system. Rna (New York, N.Y.). 9: 1418-21. PMID 14623997 DOI: 10.1261/Rna.5139703  0.357
2003 Cukras AR, Southworth DR, Brunelle JL, Culver GM, Green R. Ribosomal proteins S12 and S13 function as control elements for translocation of the mRNA:tRNA complex. Molecular Cell. 12: 321-8. PMID 14536072 DOI: 10.1016/S1097-2765(03)00275-2  0.703
2003 Southworth DR, Green R. Ribosomal translocation: sparsomycin pushes the button. Current Biology : Cb. 13: R652-4. PMID 12932345 DOI: 10.1016/S0960-9822(03)00574-8  0.557
2002 Southworth DR, Brunelle JL, Green R. EFG-independent translocation of the mRNA:tRNA complex is promoted by modification of the ribosome with thiol-specific reagents. Journal of Molecular Biology. 324: 611-23. PMID 12460565 DOI: 10.1016/S0022-2836(02)01196-8  0.581
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