Year |
Citation |
Score |
2023 |
Lue NF, Autexier C. Orchestrating nucleic acid-protein interactions at chromosome ends: telomerase mechanisms come into focus. Nature Structural & Molecular Biology. 30: 878-890. PMID 37400652 DOI: 10.1038/s41594-023-01022-7 |
0.41 |
|
2021 |
Garus A, Autexier C. Dyskerin: an essential pseudouridine synthase with multifaceted roles in ribosome biogenesis, splicing, and telomere maintenance. Rna (New York, N.Y.). 27: 1441-1458. PMID 34556550 DOI: 10.1261/rna.078953.121 |
0.367 |
|
2020 |
Qin J, Autexier C. Regulation of human telomerase RNA biogenesis and localization. Rna Biology. PMID 32813614 DOI: 10.1080/15476286.2020.1809196 |
0.505 |
|
2019 |
MacNeil DE, Lambert-Lanteigne P, Autexier C. N-terminal residues of human dyskerin are required for interactions with telomerase RNA that prevent RNA degradation. Nucleic Acids Research. PMID 30931479 DOI: 10.1093/Nar/Gkz233 |
0.478 |
|
2017 |
Dan J, Rousseau P, Hardikar S, Veland N, Wong J, Autexier C, Chen T. Zscan4 Inhibits Maintenance DNA Methylation to Facilitate Telomere Elongation in Mouse Embryonic Stem Cells. Cell Reports. 20: 1936-1949. PMID 28834755 DOI: 10.1016/J.Celrep.2017.07.070 |
0.403 |
|
2016 |
Chu TW, MacNeil DE, Autexier C. Multiple Mechanisms Contribute to the Cell Growth Defects Imparted by Human Telomerase Insertion in Fingers Domain Mutations Associated with Premature Aging Diseases. The Journal of Biological Chemistry. PMID 26887940 DOI: 10.1074/Jbc.M116.714782 |
0.415 |
|
2016 |
Rousseau P, Khondaker S, Zhu S, Lauzon C, Mai S, Autexier C. An intact putative mouse telomerase essential N-terminal (TEN) domain is necessary for proper telomere maintenance. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. PMID 26787169 DOI: 10.1111/Boc.201500089 |
0.517 |
|
2015 |
Mancini J, Rousseau P, Castor KJ, Sleiman HF, Autexier C. Platinum(II) Phenanthroimidazole G-Quadruplex Ligand Induces Selective Telomere Shortening in A549 cancer cells. Biochimie. PMID 26724375 DOI: 10.1016/J.Biochi.2015.12.015 |
0.403 |
|
2015 |
Chu TW, D'Souza Y, Autexier C. The human telomerase 'Insertion in Fingers Domain' can mediate enzyme processivity and telomerase recruitment to telomeres in a TPP1-dependent manner. Molecular and Cellular Biology. PMID 26503784 DOI: 10.1128/Mcb.00746-15 |
0.491 |
|
2015 |
Spinella JF, Cassart P, Garnier N, Rousseau P, Drullion C, Richer C, Ouimet M, Saillour V, Healy J, Autexier C, Sinnett D. A novel somatic mutation in ACD induces telomere lengthening and apoptosis resistance in leukemia cells. Bmc Cancer. 15: 621. PMID 26345285 DOI: 10.1186/S12885-015-1639-5 |
0.321 |
|
2015 |
Rousseau P, Autexier C. Telomere biology: Rationale for diagnostics and therapeutics in cancer. Rna Biology. 1-5. PMID 26291128 DOI: 10.1080/15476286.2015.1081329 |
0.308 |
|
2014 |
Zhu S, Rousseau P, Lauzon C, Gandin V, Topisirovic I, Autexier C. Inactive C-terminal telomerase reverse transcriptase insertion splicing variants are dominant-negative inhibitors of telomerase. Biochimie. 101: 93-103. PMID 24412622 DOI: 10.1016/J.Biochi.2013.12.023 |
0.525 |
|
2014 |
Brault ME, Lauzon C, Autexier C. Corrigendum to Dyskeratosis congenita mutations in dyskerin sumoylation consensus sites lead to impaired telomerase RNA accumulation and telomere defects [Human Molecular Genetics 22, 17, (2013) 3498-3507] DOI: 10.1093/hmg/ddt204 Human Molecular Genetics. 23: 279-280. DOI: 10.1093/hmg/ddt506 |
0.305 |
|
2013 |
Shawi M, Chu TW, Martinez-Marignac V, Yu Y, Gryaznov SM, Johnston JB, Lees-Miller SP, Assouline SE, Autexier C, Aloyz R. Telomerase contributes to fludarabine resistance in primary human leukemic lymphocytes. Plos One. 8: e70428. PMID 23922990 DOI: 10.1371/Journal.Pone.0070428 |
0.694 |
|
2013 |
Brault ME, Lauzon C, Autexier C. Dyskeratosis congenita mutations in dyskerin SUMOylation consensus sites lead to impaired telomerase RNA accumulation and telomere defects. Human Molecular Genetics. 22: 3498-507. PMID 23660516 DOI: 10.1093/Hmg/Ddt204 |
0.436 |
|
2013 |
D'Souza Y, Chu TW, Autexier C. A translocation-defective telomerase with low levels of activity and processivity stabilizes short telomeres and confers immortalization. Molecular Biology of the Cell. 24: 1469-79. PMID 23447707 DOI: 10.1091/Mbc.E12-12-0889 |
0.53 |
|
2013 |
D'Souza Y, Lauzon C, Chu TW, Autexier C. Regulation of telomere length and homeostasis by telomerase enzyme processivity. Journal of Cell Science. 126: 676-87. PMID 23178942 DOI: 10.1242/Jcs.119297 |
0.537 |
|
2012 |
Trapp-Fragnet L, Marie-Egyptienne DT, Fakhoury J, Rasschaert D, Autexier C. The human telomerase catalytic subunit and viral telomerase RNA reconstitute a functional telomerase complex in a cell-free system, but not in human cells. Cellular & Molecular Biology Letters. 17: 598-615. PMID 22941205 DOI: 10.2478/S11658-012-0031-6 |
0.547 |
|
2012 |
Castor KJ, Mancini J, Fakhoury J, Weill N, Kieltyka R, Englebienne P, Avakyan N, Mittermaier A, Autexier C, Moitessier N, Sleiman HF. Platinum(II) phenanthroimidazoles for targeting telomeric G-quadruplexes. Chemmedchem. 7: 85-94. PMID 22052801 DOI: 10.1002/Cmdc.201100453 |
0.377 |
|
2011 |
Brault ME, Autexier C. ALTered telomeres in response to telomere dysfunction. Cell Cycle (Georgetown, Tex.). 10: 3807-9. PMID 22064443 DOI: 10.4161/Cc.10.22.18188 |
0.347 |
|
2011 |
Brault ME, Autexier C. Telomeric recombination induced by dysfunctional telomeres. Molecular Biology of the Cell. 22: 179-88. PMID 21118998 DOI: 10.1091/Mbc.E10-02-0173 |
0.475 |
|
2011 |
Shawi M, Amrein L, Gryaznov S, Autexier C, Aloyz R. 9204 ORAL Telomerase Inhibition Affects Fludarabine Sensitivity in Primary Chronic Lymphocytic Leukemia Lymphocytes European Journal of Cancer. 47: S640-S641. DOI: 10.1016/S0959-8049(11)72469-8 |
0.618 |
|
2010 |
Fakhoury J, Marie-Egyptienne DT, Londoño-Vallejo JA, Autexier C. Telomeric function of mammalian telomerases at short telomeres. Journal of Cell Science. 123: 1693-704. PMID 20427319 DOI: 10.1242/Jcs.063636 |
0.507 |
|
2010 |
Shawi M, Amrein L, Gryaznov S, Autexier C, Aloyz R. Abstract 3207: Telomerase inhibition affects fludarabine sensitivity in quiescent primary chronic lymphocytic leukemia lymphocytes Cancer Research. 70: 3207-3207. DOI: 10.1158/1538-7445.Am10-3207 |
0.693 |
|
2009 |
Marie-Egyptienne DT, Brault ME, Nimmo GA, Londoño-Vallejo JA, Autexier C. Growth defects in mouse telomerase RNA-deficient cells expressing a template-mutated mouse telomerase RNA. Cancer Letters. 275: 266-76. PMID 19056167 DOI: 10.1016/J.Canlet.2008.10.027 |
0.42 |
|
2008 |
Shawi M, Autexier C. Telomerase, senescence and ageing. Mechanisms of Ageing and Development. 129: 3-10. PMID 18215413 DOI: 10.1016/J.Mad.2007.11.007 |
0.707 |
|
2008 |
Marie-Egyptienne DT, Brault ME, Zhu S, Autexier C. Telomerase inhibition in a mouse cell line with long telomeres leads to rapid telomerase reactivation. Experimental Cell Research. 314: 668-75. PMID 18067891 DOI: 10.1016/J.Yexcr.2007.10.020 |
0.501 |
|
2007 |
Fakhoury J, Nimmo GA, Autexier C. Harnessing telomerase in cancer therapeutics. Anti-Cancer Agents in Medicinal Chemistry. 7: 475-83. PMID 17630922 DOI: 10.2174/187152007781058622 |
0.437 |
|
2006 |
Cerone MA, Londoño-Vallejo JA, Autexier C. Telomerase inhibition enhances the response to anticancer drug treatment in human breast cancer cells. Molecular Cancer Therapeutics. 5: 1669-75. PMID 16891452 DOI: 10.1158/1535-7163.Mct-06-0033 |
0.346 |
|
2006 |
Cerone MA, Londoño-Vallejo JA, Autexier C. Mutated telomeres sensitize tumor cells to anticancer drugs independently of telomere shortening and mechanisms of telomere maintenance. Oncogene. 25: 7411-20. PMID 16767163 DOI: 10.1038/Sj.Onc.1209727 |
0.474 |
|
2006 |
Autexier C, Lue NF. The structure and function of telomerase reverse transcriptase. Annual Review of Biochemistry. 75: 493-517. PMID 16756500 DOI: 10.1146/Annurev.Biochem.75.103004.142412 |
0.434 |
|
2005 |
Marie-Egyptienne DT, Cerone MA, Londoño-Vallejo JA, Autexier C. A human-Tetrahymena pseudoknot chimeric telomerase RNA reconstitutes a nonprocessive enzyme in vitro that is defective in telomere elongation. Nucleic Acids Research. 33: 5446-57. PMID 16192571 DOI: 10.1093/Nar/Gki848 |
0.558 |
|
2005 |
Moriarty TJ, Marie-Egyptienne DT, Autexier C. Regulation of 5' template usage and incorporation of noncognate nucleotides by human telomerase. Rna (New York, N.Y.). 11: 1448-60. PMID 16120835 DOI: 10.1261/Rna.2910105 |
0.471 |
|
2005 |
Cerone MA, Autexier C, Londoño-Vallejo JA, Bacchetti S. A human cell line that maintains telomeres in the absence of telomerase and of key markers of ALT. Oncogene. 24: 7893-901. PMID 16116482 DOI: 10.1038/Sj.Onc.1208934 |
0.437 |
|
2005 |
Lue NF, Bosoy D, Moriarty TJ, Autexier C, Altman B, Leng S. Telomerase can act as a template- and RNA-independent terminal transferase. Proceedings of the National Academy of Sciences of the United States of America. 102: 9778-83. PMID 15994230 DOI: 10.1073/Pnas.0502252102 |
0.522 |
|
2005 |
Ward RJ, Autexier C. Pharmacological telomerase inhibition can sensitize drug-resistant and drug-sensitive cells to chemotherapeutic treatment. Molecular Pharmacology. 68: 779-86. PMID 15939802 DOI: 10.1124/Mol.105.011494 |
0.319 |
|
2005 |
Moriarty TJ, Ward RJ, Taboski MA, Autexier C. An anchor site-type defect in human telomerase that disrupts telomere length maintenance and cellular immortalization. Molecular Biology of the Cell. 16: 3152-61. PMID 15857955 DOI: 10.1091/Mbc.E05-02-0148 |
0.486 |
|
2005 |
Cerone MA, Ward RJ, Londoño-Vallejo JA, Autexier C. Telomerase RNA mutated in autosomal dyskeratosis congenita reconstitutes a weakly active telomerase enzyme defective in telomere elongation. Cell Cycle (Georgetown, Tex.). 4: 585-9. PMID 15753647 DOI: 10.4161/Cc.4.4.1586 |
0.418 |
|
2004 |
Huard S, Autexier C. Human telomerase catalyzes nucleolytic primer cleavage. Nucleic Acids Research. 32: 2171-80. PMID 15096579 DOI: 10.1093/Nar/Gkh546 |
0.53 |
|
2004 |
Moriarty TJ, Marie-Egyptienne DT, Autexier C. Functional organization of repeat addition processivity and DNA synthesis determinants in the human telomerase multimer. Molecular and Cellular Biology. 24: 3720-33. PMID 15082768 DOI: 10.1128/Mcb.24.9.3720-3733.2004 |
0.486 |
|
2004 |
Bah A, Bachand F, Clair E, Autexier C, Wellinger RJ. Humanized telomeres and an attempt to express a functional human telomerase in yeast. Nucleic Acids Research. 32: 1917-27. PMID 15047858 DOI: 10.1093/Nar/Gkh511 |
0.74 |
|
2003 |
Huard S, Moriarty TJ, Autexier C. The C terminus of the human telomerase reverse transcriptase is a determinant of enzyme processivity. Nucleic Acids Research. 31: 4059-70. PMID 12853623 DOI: 10.1093/Nar/Gkg437 |
0.44 |
|
2002 |
Huard S, Autexier C. Targeting human telomerase in cancer therapy. Current Medicinal Chemistry. Anti-Cancer Agents. 2: 577-87. PMID 12678725 DOI: 10.2174/1568011023353822 |
0.5 |
|
2002 |
Boisvert FM, Cote J, Boulanger MC, Cleroux P, Bachand F, Autexier C, Richard S. Symmetrical dimethylarginine methylation is required for the localization of SMN in Cajal bodies and pre-mRNA splicing. The Journal of Cell Biology. 159: 957-69. PMID 12486110 DOI: 10.1083/Jcb.200207028 |
0.621 |
|
2002 |
Bachand F, Boisvert FM, Côté J, Richard S, Autexier C. The product of the survival of motor neuron (SMN) gene is a human telomerase-associated protein. Molecular Biology of the Cell. 13: 3192-202. PMID 12221125 DOI: 10.1091/Mbc.E02-04-0216 |
0.721 |
|
2002 |
Moriarty TJ, Dupuis S, Autexier C. Rapid upregulation of telomerase activity in human leukemia HL-60 cells treated with clinical doses of the DNA-damaging drug etoposide. Leukemia. 16: 1112-20. PMID 12040441 DOI: 10.1038/Sj.Leu.2402522 |
0.391 |
|
2002 |
Moriarty TJ, Huard S, Dupuis S, Autexier C. Functional multimerization of human telomerase requires an RNA interaction domain in the N terminus of the catalytic subunit. Molecular and Cellular Biology. 22: 1253-65. PMID 11809815 DOI: 10.1128/Mcb.22.4.1253-1265.2002 |
0.519 |
|
2001 |
Mason DX, Autexier C, Greider CW. Tetrahymena proteins p80 and p95 are not core telomerase components. Proceedings of the National Academy of Sciences of the United States of America. 98: 12368-73. PMID 11592988 DOI: 10.1073/Pnas.221456398 |
0.723 |
|
2001 |
Bachand F, Triki I, Autexier C. Human telomerase RNA-protein interactions. Nucleic Acids Research. 29: 3385-93. PMID 11504876 DOI: 10.1093/Nar/29.16.3385 |
0.738 |
|
2001 |
Bachand F, Autexier C. Functional regions of human telomerase reverse transcriptase and human telomerase RNA required for telomerase activity and RNA-protein interactions. Molecular and Cellular Biology. 21: 1888-97. PMID 11238925 DOI: 10.1128/Mcb.21.5.1888-1897.2001 |
0.753 |
|
2000 |
Bachand F, Kukolj G, Autexier C. Expression of hTERT and hTR in cis reconstitutes and active human telomerase ribonucleoprotein. Rna (New York, N.Y.). 6: 778-84. PMID 10836798 DOI: 10.1017/S1355838200000261 |
0.73 |
|
2000 |
Autexier C. Tetrahymena telomerase activity, purification, and reconstitution. Methods in Cell Biology. 62: 395-415. PMID 10503206 DOI: 10.1016/S0091-679X(08)61545-9 |
0.45 |
|
1999 |
Bachand F, Autexier C. Functional reconstitution of human telomerase expressed in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 274: 38027-31. PMID 10608871 DOI: 10.1074/Jbc.274.53.38027 |
0.72 |
|
1999 |
Autexier C. Telomerase as a possible target for anticancer therapy. Chemistry & Biology. 6: R299-303. PMID 10574787 DOI: 10.1016/S1074-5521(99)80122-7 |
0.402 |
|
1999 |
Autexier C, Triki I. Tetrahymena telomerase ribonucleoprotein RNA-protein interactions. Nucleic Acids Research. 27: 2227-34. PMID 10219097 DOI: 10.1093/nar/27.10.2227 |
0.402 |
|
1999 |
Bachand F, Autexier C. Le rôle de la télomérase et des télomères dans l'immortalisation cellulaire. MéDecine/Sciences. 15: 1286. DOI: 10.4267/10608/1259 |
0.546 |
|
1999 |
Bachand F, Autexier C. Telomerase and telomeres in cell immortalisation | Le role de la telomerase et des telomeres dans l'immortalisation cellulaire Medecine/Sciences. 15: 1286-1291. |
0.611 |
|
1998 |
Autexier C, Greider CW. Mutational analysis of the Tetrahymena telomerase RNA: identification of residues affecting telomerase activity in vitro. Nucleic Acids Research. 26: 787-95. PMID 9443971 DOI: 10.1093/Nar/26.3.787 |
0.699 |
|
1996 |
Autexier C, Pruzan R, Funk WD, Greider CW. Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA. The Embo Journal. 15: 5928-35. PMID 8918470 DOI: 10.1002/J.1460-2075.1996.Tb00979.X |
0.713 |
|
1996 |
Autexier C, Greider CW. Telomerase and cancer: revisiting the telomere hypothesis. Trends in Biochemical Sciences. 21: 387-91. PMID 8918193 DOI: 10.1016/S0968-0004(96)10042-6 |
0.667 |
|
1996 |
Greider CW, Collins K, Autexier C. 21 DNA Telomerases Cold Spring Harbor Monograph Archive. 31: 619-638. DOI: 10.1101/087969459.31.619 |
0.712 |
|
1995 |
Autexier C, Greider CW. Boundary elements of the Tetrahymena telomerase RNA template and alignment domains. Genes & Development. 9: 2227-39. PMID 7557377 DOI: 10.1101/Gad.9.18.2227 |
0.692 |
|
1994 |
Benevides JM, Kukolj G, Autexier C, Aubrey KL, DuBow MS, Thomas GJ. Secondary structure and interaction of phage D108 Ner repressor with a 61-base-pair operator: evidence for altered protein and DNA structures in the complex. Biochemistry. 33: 10701-10. PMID 8075070 DOI: 10.1021/Bi00201A018 |
0.311 |
|
1994 |
Autexier C, Greider CW. Functional reconstitution of wild-type and mutant Tetrahymena telomerase. Genes & Development. 8: 563-75. PMID 7523243 DOI: 10.1101/Gad.8.5.563 |
0.685 |
|
1989 |
Kukolj G, Tolias PP, Autexier C, DuBow MS. DNA-directed oligomerization of the monomeric Ner repressor from the Mu-like bacteriophage D108. The Embo Journal. 8: 3141-8. PMID 2531076 DOI: 10.1002/J.1460-2075.1989.Tb08467.X |
0.328 |
|
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