Daniel E. Gottschling - Publications

Affiliations: 
Fred Hutchinson Cancer Research Center, Seattle, WA, United States 
Area:
cellular aging
Website:
http://labs.fhcrc.org/gottschling/

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Hughes AL, Hughes CE, Henderson KA, Yazvenko N, Gottschling DE. Selective sorting and destruction of mitochondrial membrane proteins in aged yeast. Elife. 5. PMID 27097106 DOI: 10.7554/Elife.13943  1
2014 Thayer NH, Leverich CK, Fitzgibbon MP, Nelson ZW, Henderson KA, Gafken PR, Hsu JJ, Gottschling DE. Identification of long-lived proteins retained in cells undergoing repeated asymmetric divisions. Proceedings of the National Academy of Sciences of the United States of America. 111: 14019-26. PMID 25228775 DOI: 10.1073/Pnas.1416079111  1
2014 Dillin A, Gottschling DE, Nyström T. The good and the bad of being connected: the integrons of aging. Current Opinion in Cell Biology. 26: 107-12. PMID 24529252 DOI: 10.1016/J.Ceb.2013.12.003  1
2012 Hughes AL, Gottschling DE. An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast. Nature. 492: 261-5. PMID 23172144 DOI: 10.1038/Nature11654  1
2012 Gottschling DE. Molecular biology. Fragile delivery to the genome. Science (New York, N.Y.). 337: 160-1. PMID 22798587 DOI: 10.1126/Science.1225852  1
2012 Hotz M, Leisner C, Chen D, Manatschal C, Wegleiter T, Ouellet J, Lindstrom D, Gottschling DE, Vogel J, Barral Y. Spindle pole bodies exploit the mitotic exit network in metaphase to drive their age-dependent segregation. Cell. 148: 958-72. PMID 22385961 DOI: 10.1016/J.Cell.2012.01.041  1
2011 Dymond JS, Richardson SM, Coombes CE, Babatz T, Muller H, Annaluru N, Blake WJ, Schwerzmann JW, Dai J, Lindstrom DL, Boeke AC, Gottschling DE, Chandrasegaran S, Bader JS, Boeke JD. Synthetic chromosome arms function in yeast and generate phenotypic diversity by design. Nature. 477: 471-6. PMID 21918511 DOI: 10.1038/Nature10403  1
2011 Lindstrom DL, Leverich CK, Henderson KA, Gottschling DE. Replicative age induces mitotic recombination in the ribosomal RNA gene cluster of Saccharomyces cerevisiae. Plos Genetics. 7: e1002015. PMID 21436897 DOI: 10.1371/Journal.Pgen.1002015  1
2011 Rosenbaum JC, Fredrickson EK, Oeser ML, Garrett-Engele CM, Locke MN, Richardson LA, Nelson ZW, Hetrick ED, Milac TI, Gottschling DE, Gardner RG. Disorder targets misorder in nuclear quality control degradation: a disordered ubiquitin ligase directly recognizes its misfolded substrates. Molecular Cell. 41: 93-106. PMID 21211726 DOI: 10.1016/J.Molcel.2010.12.004  1
2010 Verzijlbergen KF, Menendez-Benito V, van Welsem T, van Deventer SJ, Lindstrom DL, Ovaa H, Neefjes J, Gottschling DE, van Leeuwen F. Recombination-induced tag exchange to track old and new proteins. Proceedings of the National Academy of Sciences of the United States of America. 107: 64-8. PMID 20018668 DOI: 10.1073/Pnas.0911164107  1
2009 Lindstrom DL, Gottschling DE. The mother enrichment program: a genetic system for facile replicative life span analysis in Saccharomyces cerevisiae. Genetics. 183: 413-22, 1SI-13SI. PMID 19652178 DOI: 10.1534/Genetics.109.106229  1
2009 Dimitrov LN, Brem RB, Kruglyak L, Gottschling DE. Polymorphisms in multiple genes contribute to the spontaneous mitochondrial genome instability of Saccharomyces cerevisiae S288C strains. Genetics. 183: 365-83. PMID 19581448 DOI: 10.1534/Genetics.109.104497  1
2009 Veatch JR, McMurray MA, Nelson ZW, Gottschling DE. Mitochondrial dysfunction leads to nuclear genome instability via an iron-sulfur cluster defect. Cell. 137: 1247-58. PMID 19563757 DOI: 10.1016/J.Cell.2009.04.014  1
2008 Henderson KA, Gottschling DE. A mother's sacrifice: what is she keeping for herself? Current Opinion in Cell Biology. 20: 723-8. PMID 18848886 DOI: 10.1016/J.Ceb.2008.09.004  1
2008 Andersen MP, Nelson ZW, Hetrick ED, Gottschling DE. A genetic screen for increased loss of heterozygosity in Saccharomyces cerevisiae. Genetics. 179: 1179-95. PMID 18562670 DOI: 10.1534/Genetics.108.089250  1
2008 van Welsem T, Frederiks F, Verzijlbergen KF, Faber AW, Nelson ZW, Egan DA, Gottschling DE, van Leeuwen F. Synthetic lethal screens identify gene silencing processes in yeast and implicate the acetylated amino terminus of Sir3 in recognition of the nucleosome core. Molecular and Cellular Biology. 28: 3861-72. PMID 18391024 DOI: 10.1128/Mcb.02050-07  1
2008 Carr LL, Gottschling DE. Does age influence loss of heterozygosity? Experimental Gerontology. 43: 123-9. PMID 18054191 DOI: 10.1016/J.Exger.2007.10.010  1
2006 Gottschling DE. DNA repair: corrections in the golden years. Current Biology : Cb. 16: R956-8. PMID 17113375 DOI: 10.1016/J.Cub.2006.10.016  1
2005 Gardner RG, Nelson ZW, Gottschling DE. Ubp10/Dot4p regulates the persistence of ubiquitinated histone H2B: distinct roles in telomeric silencing and general chromatin. Molecular and Cellular Biology. 25: 6123-39. PMID 15988024 DOI: 10.1128/Mcb.25.14.6123-6139.2005  1
2005 Gardner RG, Nelson ZW, Gottschling DE. Degradation-mediated protein quality control in the nucleus. Cell. 120: 803-15. PMID 15797381 DOI: 10.1016/J.Cell.2005.01.016  1
2005 Xu EY, Bi X, Holland MJ, Gottschling DE, Broach JR. Mutations in the nucleosome core enhance transcriptional silencing. Molecular and Cellular Biology. 25: 1846-59. PMID 15713639 DOI: 10.1128/Mcb.25.5.1846-1859.2005  1
2005 Koschwanez J, Holl M, Carlson R, McMurray M, Gottschling D, Meldrum D. Automated lifetime analysis of a single yeast cell Proceedings of the 2005 Ieee Conference On Automation Science and Engineering, Ieee-Case 2005. 2005: 13-18. DOI: 10.1109/COASE.2005.1506738  1
2004 Gottschling DE. Summary: epigenetics--from phenomenon to field. Cold Spring Harbor Symposia On Quantitative Biology. 69: 507-19. PMID 16117688 DOI: 10.1101/Sqb.2004.69.507  1
2004 McMurray MA, Gottschling DE. Genetic instability in aging yeast: a metastable hyperrecombinational state. Cold Spring Harbor Symposia On Quantitative Biology. 69: 339-47. PMID 16117666 DOI: 10.1101/Sqb.2004.69.339  1
2004 McMurray MA, Gottschling DE. Aging and genetic instability in yeast. Current Opinion in Microbiology. 7: 673-9. PMID 15556042 DOI: 10.1016/J.Mib.2004.10.008  1
2004 Schübeler D, MacAlpine DM, Scalzo D, Wirbelauer C, Kooperberg C, van Leeuwen F, Gottschling DE, O'Neill LP, Turner BM, Delrow J, Bell SP, Groudine M. The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote. Genes & Development. 18: 1263-71. PMID 15175259 DOI: 10.1101/Gad.1198204  1
2004 Koschwanez J, Holl M, McMurray M, Gottschling D, Meldrum D. Automation of yeast pedigree analysis Proceedings - Ieee International Conference On Robotics and Automation. 2004: 1475-1480.  1
2003 McMurray MA, Gottschling DE. An age-induced switch to a hyper-recombinational state. Science (New York, N.Y.). 301: 1908-11. PMID 14512629 DOI: 10.1126/Science.1087706  1
2003 Stellwagen AE, Haimberger ZW, Veatch JR, Gottschling DE. Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends. Genes & Development. 17: 2384-95. PMID 12975323 DOI: 10.1101/Gad.1125903  1
2003 Smith CM, Gafken PR, Zhang Z, Gottschling DE, Smith JB, Smith DL. Mass spectrometric quantification of acetylation at specific lysines within the amino-terminal tail of histone H4. Analytical Biochemistry. 316: 23-33. PMID 12694723 DOI: 10.1016/S0003-2697(03)00032-0  1
2003 van Leeuwen F, Gottschling DE. The histone minority report: the variant shall not be silenced. Cell. 112: 591-3. PMID 12628179 DOI: 10.1016/S0092-8674(03)00152-1  1
2002 van Leeuwen F, Gottschling DE. Genome-wide histone modifications: gaining specificity by preventing promiscuity. Current Opinion in Cell Biology. 14: 756-62. PMID 12473351 DOI: 10.1016/S0955-0674(02)00393-9  1
2002 DuBois ML, Haimberger ZW, McIntosh MW, Gottschling DE. A quantitative assay for telomere protection in Saccharomyces cerevisiae. Genetics. 161: 995-1013. PMID 12136006  1
2002 van Leeuwen F, Gafken PR, Gottschling DE. Dot1p modulates silencing in yeast by methylation of the nucleosome core. Cell. 109: 745-56. PMID 12086673 DOI: 10.1016/S0092-8674(02)00759-6  1
2002 van Leeuwen F, Gottschling DE. Assays for gene silencing in yeast. Methods in Enzymology. 350: 165-86. PMID 12073311 DOI: 10.1016/S0076-6879(02)50962-9  1
2001 Bedalov A, Gatbonton T, Irvine WP, Gottschling DE, Simon JA. Identification of a small molecule inhibitor of Sir2p. Proceedings of the National Academy of Sciences of the United States of America. 98: 15113-8. PMID 11752457 DOI: 10.1073/Pnas.261574398  1
2001 Diede SJ, Gottschling DE. Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere. Current Biology : Cb. 11: 1336-40. PMID 11553326 DOI: 10.1016/S0960-9822(01)00400-6  1
2001 Peterson SE, Stellwagen AE, Diede SJ, Singer MS, Haimberger ZW, Johnson CO, Tzoneva M, Gottschling DE. The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku. Nature Genetics. 27: 64-7. PMID 11138000 DOI: 10.1038/83778  1
2001 Gottschling DE. Ab initio calculations on the multipole moments and dipole polarisabilities of the PO+ molecular ion (X1∑+) Journal of Molecular Structure: Theochem. 540: 139-144. DOI: 10.1016/S0166-1280(00)00727-2  1
2000 DuBois ML, Diede SJ, Stellwagen AE, Gottschling DE. All things must end: telomere dynamics in yeast. Cold Spring Harbor Symposia On Quantitative Biology. 65: 281-96. PMID 12760042 DOI: 10.1101/Sqb.2000.65.281  1
2000 Gottschling DE. Gene silencing: two faces of SIR2. Current Biology : Cb. 10: R708-11. PMID 11050406 DOI: 10.1016/S0960-9822(00)00714-4  1
2000 Kelly TJ, Qin S, Gottschling DE, Parthun MR. Type B histone acetyltransferase Hat1p participates in telomeric silencing. Molecular and Cellular Biology. 20: 7051-8. PMID 10982821 DOI: 10.1128/Mcb.20.19.7051-7058.2000  1
1999 Diede SJ, Gottschling DE. Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta. Cell. 99: 723-33. PMID 10619426 DOI: 10.1016/S0092-8674(00)81670-0  1
1999 Kahana A, Gottschling DE. DOT4 links silencing and cell growth in Saccharomyces cerevisiae. Molecular and Cellular Biology. 19: 6608-20. PMID 10490600 DOI: 10.1128/Mcb.19.10.6608  1
1999 Gottschling DE, Stoddard B. Telomeres: structure of a chromosome's aglet. Current Biology : Cb. 9: R164-7. PMID 10074444 DOI: 10.1016/S0960-9822(99)80103-1  1
1999 Stevenson JB, Gottschling DE. Telomeric chromatin modulates replication timing near chromosome ends. Genes & Development. 13: 146-51. PMID 9925638 DOI: 10.1101/Gad.13.2.146  1
1998 Singer MS, Kahana A, Wolf AJ, Meisinger LL, Peterson SE, Goggin C, Mahowald M, Gottschling DE. Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae. Genetics. 150: 613-32. PMID 9755194  1
1998 Gottschling DE, Berg BL. Chromosome dynamics: yeast pulls it apart. Current Biology : Cb. 8: R76-9. PMID 9443905 DOI: 10.1016/S0960-9822(98)70050-8  1
1997 Huang H, Kahana A, Gottschling DE, Prakash L, Liebman SW. The ubiquitin-conjugating enzyme Rad6 (Ubc2) is required for silencing in Saccharomyces cerevisiae. Molecular and Cellular Biology. 17: 6693-9. PMID 9343433 DOI: 10.1128/Mcb.17.11.6693  1
1996 Parthun MR, Widom J, Gottschling DE. The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism. Cell. 87: 85-94. PMID 8858151 DOI: 10.1016/S0092-8674(00)81325-2  1
1994 Sandell LL, Gottschling DE, Zakian VA. Transcription of a yeast telomere alleviates telomere position effect without affecting chromosome stability. Proceedings of the National Academy of Sciences of the United States of America. 91: 12061-5. PMID 7991584 DOI: 10.1073/Pnas.91.25.12061  1
1994 Aparicio OM, Gottschling DE. Overcoming telomeric silencing: a trans-activator competes to establish gene expression in a cell cycle-dependent way. Genes & Development. 8: 1133-46. PMID 7926719 DOI: 10.1101/Gad.8.10.1133  1
1994 Singer MS, Gottschling DE. TLC1: template RNA component of Saccharomyces cerevisiae telomerase. Science (New York, N.Y.). 266: 404-9. PMID 7545955 DOI: 10.1126/Science.7545955  1
1993 Renauld H, Aparicio OM, Zierath PD, Billington BL, Chhablani SK, Gottschling DE. Silent domains are assembled continuously from the telomere and are defined by promoter distance and strength, and by SIR3 dosage. Genes & Development. 7: 1133-45. PMID 8319906 DOI: 10.1101/Gad.7.7A.1133  1
1992 Wright JH, Gottschling DE, Zakian VA. Saccharomyces telomeres assume a non-nucleosomal chromatin structure. Genes & Development. 6: 197-210. PMID 1737616 DOI: 10.1101/Gad.6.2.197  1
1992 Gottschling DE. Telomere-proximal DNA in Saccharomyces cerevisiae is refractory to methyltransferase activity in vivo. Proceedings of the National Academy of Sciences of the United States of America. 89: 4062-5. PMID 1570334 DOI: 10.1073/Pnas.89.9.4062  1
1991 Aparicio OM, Billington BL, Gottschling DE. Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae. Cell. 66: 1279-87. PMID 1913809 DOI: 10.1016/0092-8674(91)90049-5  1
1990 Gottschling DE, Aparicio OM, Billington BL, Zakian VA. Position effect at S. cerevisiae telomeres: reversible repression of Pol II transcription. Cell. 63: 751-62. PMID 2225075 DOI: 10.1016/0092-8674(90)90141-Z  1
1988 Gottschling DE, Zakian VA. Dna-Protein Interactions at Telomeres in Ciliated Protozoans Advances in Molecular and Cell Biology. 2: 291-307. DOI: 10.1016/S1569-2558(08)60438-5  1
1986 Gottschling DE, Zakian VA. Telomere proteins: specific recognition and protection of the natural termini of Oxytricha macronuclear DNA. Cell. 47: 195-205. PMID 3094961 DOI: 10.1016/0092-8674(86)90442-3  1
1984 Gottschling DE, Cech TR. Chromatin structure of the molecular ends of Oxytricha macronuclear DNA: phased nucleosomes and a telomeric complex. Cell. 38: 501-10. PMID 6432344 DOI: 10.1016/0092-8674(84)90505-1  1
1983 Gottschling DE, Palen TE, Cech TR. Different nucleosome spacing in transcribed and non-transcribed regions of the ribosomal RNA gene in Tetrahymena thermophila. Nucleic Acids Research. 11: 2093-109. PMID 6835846 DOI: 10.1093/Nar/11.7.2093  1
1982 Kruger K, Grabowski PJ, Zaug AJ, Sands J, Gottschling DE, Cech TR. Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena. Cell. 31: 147-57. PMID 6297745 DOI: 10.1016/0092-8674(82)90414-7  1
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