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Year Citation  Score
2019 Sayed ME, Cheng A, Yadav GP, Ludlow AT, Shay JW, Wright WE, Jiang QX. Catalysis-dependent inactivation of human telomerase and its reactivation by intracellular telomerase-activating factors (iTAFs). The Journal of Biological Chemistry. PMID 31186347 DOI: 10.1074/jbc.RA118.007234  0.72
2019 Min J, Wright WE, Shay JW. Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52. Genes & Development. PMID 31171703 DOI: 10.1101/gad.324905.119  0.72
2019 Shay JW, Wright WE. Telomeres and telomerase: three decades of progress. Nature Reviews. Genetics. PMID 30760854 DOI: 10.1038/s41576-019-0099-1  0.72
2018 Sayed ME, Yuan L, Robin JD, Tedone E, Batten K, Dahlson N, Wright WE, Shay JW, Ludlow AT. NOVA1 directs PTBP1 to hTERT pre-mRNA and promotes telomerase activity in cancer cells. Oncogene. PMID 30568224 DOI: 10.1038/s41388-018-0639-8  0.72
2018 Tedone E, Huang E, O'Hara R, Batten K, Ludlow AT, Lai TP, Arosio B, Mari D, Wright WE, Shay JW. Telomere length and telomerase activity in T cells are biomarkers of high-performing centenarians. Aging Cell. e12859. PMID 30488553 DOI: 10.1111/acel.12859  0.72
2018 Ludlow AT, Wong MS, Robin JD, Batten K, Yuan L, Lai TP, Dahlson N, Zhang L, Mender I, Tedone E, Sayed ME, Wright WE, Shay JW. NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer. Nature Communications. 9: 3112. PMID 30082712 DOI: 10.1038/s41467-018-05582-x  0.72
2018 Mender I, LaRanger R, Luitel K, Peyton M, Girard L, Lai TP, Batten K, Cornelius C, Dalvi MP, Ramirez M, Du W, Wu LF, Altschuler SJ, Brekken R, Martinez ED, ... ... Shay JW, et al. Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance. Neoplasia (New York, N.Y.). 20: 826-837. PMID 30015158 DOI: 10.1016/j.neo.2018.06.002  0.72
2018 Kim SB, Zhang L, Yoon J, Lee J, Min J, Li W, Grishin NV, Moon YA, Wright WE, Shay JW. Truncated APC Mutation Induces Asef Activated Golgi Fragmentation. Molecular and Cellular Biology. PMID 29866653 DOI: 10.1128/MCB.00135-18  0.72
2018 Ludlow AT, Shelton D, Wright WE, Shay JW. ddTRAP: A Method for Sensitive and Precise Quantification of Telomerase Activity. Methods in Molecular Biology (Clifton, N.J.). 1768: 513-529. PMID 29717462 DOI: 10.1007/978-1-4939-7778-9_29  0.72
2018 Lai TP, Wright WE, Shay JW. Comparison of telomere length measurement methods. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 373. PMID 29335378 DOI: 10.1098/rstb.2016.0451  0.72
2017 Lai TP, Zhang N, Noh J, Mender I, Tedone E, Huang E, Wright WE, Danuser G, Shay JW. A method for measuring the distribution of the shortest telomeres in cells and tissues. Nature Communications. 8: 1356. PMID 29116081 DOI: 10.1038/s41467-017-01291-z  0.72
2017 Min J, Wright WE, Shay JW. Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes. Molecular and Cellular Biology. PMID 28760773 DOI: 10.1128/MCB.00226-17  0.72
2017 Huang EE, Tedone E, O'Hara R, Cornelius C, Lai TP, Ludlow A, Wright WE, Shay JW. The Maintenance of Telomere Length in CD28+ T Cells During T Lymphocyte Stimulation. Scientific Reports. 7: 6785. PMID 28754961 DOI: 10.1038/s41598-017-05174-7  0.72
2017 LaRanger R, Peters-Hall JR, Coquelin M, Alabi BR, Chen C, Wright WE, Shay J. Reconstituting Mouse Lungs with Conditionally Reprogrammed Human Bronchial Epithelial Cells. Tissue Engineering. Part A. PMID 28726588 DOI: 10.1089/ten.TEA.2017.0114  0.72
2017 Zhao Y, Shay JW, Wright WE. Telomere Terminal G/C Strand Synthesis: Measuring Telomerase Action and C-Rich Fill-In. Methods in Molecular Biology (Clifton, N.J.). 1587: 71-82. PMID 28324499 DOI: 10.1007/978-1-4939-6892-3_7  0.72
2017 Zhao Y, Shay JW, Wright WE. Telomere G-Rich Overhang Length Measurement: DSN Method. Methods in Molecular Biology (Clifton, N.J.). 1587: 55-62. PMID 28324497 DOI: 10.1007/978-1-4939-6892-3_5  0.72
2017 Min J, Wright WE, Shay JW. Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands. Nucleic Acids Research. PMID 28082393 DOI: 10.1093/nar/gkw1295  0.72
2016 Kim W, Ludlow AT, Min J, Robin JD, Stadler G, Mender I, Lai TP, Zhang N, Wright WE, Shay JW. Regulation of the Human Telomerase Gene TERT by Telomere Position Effect-Over Long Distances (TPE-OLD): Implications for Aging and Cancer. Plos Biology. 14: e2000016. PMID 27977688 DOI: 10.1371/journal.pbio.2000016  0.72
2016 Zhang L, Theodoropoulos PC, Eskiocak U, Wang W, Moon YA, Posner B, Williams NS, Wright WE, Kim SB, Nijhawan D, De Brabander JK, Shay JW. Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer. Science Translational Medicine. 8: 361ra140. PMID 27798265 DOI: 10.1126/scitranslmed.aaf8127  0.72
2016 Holohan B, Kim W, Lai TP, Hoshiyama H, Zhang N, Alazami AM, Wright WE, Meyn MS, Alkuraya FS, Shay JW. Impaired telomere maintenance in Alazami syndrome patients with LARP7 deficiency. Bmc Genomics. 17: 749. PMID 27766953 DOI: 10.1186/s12864-016-3093-4  0.72
2016 Druliner BR, Ruan X, Johnson R, Grill D, O'Brien D, Lai TP, Rashtak S, Felmlee-Devine D, Washechek-Aletto J, Malykh A, Smyrk T, Oberg A, Liu H, Shay JW, Ahlquist DA, et al. Time Lapse to Colorectal Cancer: Telomere Dynamics Define the Malignant Potential of Polyps. Clinical and Translational Gastroenterology. 7: e188. PMID 27584834 DOI: 10.1038/ctg.2016.48  1
2016 Padanad MS, Konstantinidou G, Venkateswaran N, Melegari M, Rindhe S, Mitsche M, Yang C, Batten K, Huffman KE, Liu J, Tang X, Rodriguez-Canales J, Kalhor N, Shay JW, Minna JD, et al. Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis. Cell Reports. PMID 27477280 DOI: 10.1016/j.celrep.2016.07.009  1
2016 Lai TP, Wright WE, Shay JW. Generation of digoxigenin-incorporated probes to enhance DNA detection sensitivity. Biotechniques. 60: 306-9. PMID 27286808 DOI: 10.2144/000114427  1
2016 Frink RE, Peyton M, Schiller JH, Gazdar AF, Shay JW, Minna JD. Telomerase inhibitor imetelstat has preclinical activity across the spectrum of non-small cell lung cancer oncogenotypes in a telomere length dependent manner. Oncotarget. PMID 27192120 DOI: 10.18632/oncotarget.9335  1
2016 Robin JD, Ludlow AT, LaRanger R, Wright WE, Shay JW. Comparison of DNA Quantification Methods for Next Generation Sequencing. Scientific Reports. 6: 24067. PMID 27048884 DOI: 10.1038/srep24067  0.72
2016 Erzinger MM, Bovet C, Hecht KM, Senger S, Winiker P, Sobotzki N, Cristea S, Beerenwinkel N, Shay JW, Marra G, Wollscheid B, Sturla SJ. Sulforaphane Preconditioning Sensitizes Human Colon Cancer Cells towards the Bioreductive Anticancer Prodrug PR-104A. Plos One. 11: e0150219. PMID 26950072 DOI: 10.1371/journal.pone.0150219  1
2016 Norbury JW, Schimmerling W, Slaba TC, Azzam EI, Badavi FF, Baiocco G, Benton E, Bindi V, Blakely EA, Blattnig SR, Boothman DA, Borak TB, Britten RA, Curtis S, Dingfelder M, ... ... Shay JW, et al. Galactic cosmic ray simulation at the NASA Space Radiation Laboratory. Life Sciences in Space Research. 8: 38-51. PMID 26948012 DOI: 10.1016/j.lssr.2016.02.001  1
2016 Bhagwandin VJ, Bishop JM, Wright WE, Shay JW. The Metastatic Potential and Chemoresistance of Human Pancreatic Cancer Stem Cells. Plos One. 11: e0148807. PMID 26859746 DOI: 10.1371/journal.pone.0148807  1
2015 Niwa O, Barcellos-Hoff MH, Globus RK, Harrison JD, Hendry JH, Jacob P, Martin MT, Seed TM, Shay JW, Story MD, Suzuki K, Yamashita S. ICRP Publication 131: Stem Cell Biology with Respect to Carcinogenesis Aspects of Radiological Protection. Annals of the Icrp. 44: 7-357. PMID 26637346 DOI: 10.1177/0146645315595585  1
2015 Kim SB, Bozeman RG, Kaisani A, Kim W, Zhang L, Richardson JA, Wright WE, Shay JW. Radiation promotes colorectal cancer initiation and progression by inducing senescence-associated inflammatory responses. Oncogene. PMID 26477319 DOI: 10.1038/onc.2015.395  0.72
2015 Getachew Y, Cusimano FA, Gopal P, Reisman SA, Shay JW. The Synthetic Triterpenoid RTA 405 (CDDO-EA) Halts Progression of Liver Fibrosis and Reduces Hepatocellular Carcinoma Size Resulting in Increased Survival in an Experimental Model of Chronic Liver Injury. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26443840 DOI: 10.1093/toxsci/kfv213  1
2015 Robin JD, Ludlow AT, Batten K, Gaillard MC, Stadler G, Magdinier F, Wright WE, Shay JW. SORBS2 transcription is activated by telomere position effect-over long distance upon telomere shortening in muscle cells from patients with facioscapulohumeral dystrophy. Genome Research. PMID 26359233 DOI: 10.1101/gr.190660.115  1
2015 Holohan B, Hagiopian MM, Lai TP, Huang E, Friedman DR, Wright WE, Shay JW. Perifosine as a potential novel anti-telomerase therapy. Oncotarget. 6: 21816-26. PMID 26307677  0.72
2015 Barcellos-Hoff MH, Blakely EA, Burma S, Fornace AJ, Gerson S, Hlatky L, Kirsch DG, Luderer U, Shay J, Wang Y, Weil MM. Concepts and challenges in cancer risk prediction for the space radiation environment. Life Sciences in Space Research. 6: 92-103. PMID 26256633 DOI: 10.1016/j.lssr.2015.07.006  1
2015 Meyer CJ, Krauth M, Wick MJ, Shay JW, Gellert G, De Brabander JK, Northcote PT, Miller JH. Peloruside A inhibits growth of human lung and breast tumor xenografts in an athymic nu/nu mouse model. Molecular Cancer Therapeutics. PMID 26056149 DOI: 10.1158/1535-7163.MCT-15-0167  1
2015 Holohan B, De Meyer T, Batten K, Mangino M, Hunt SC, Bekaert S, De Buyzere ML, Rietzschel ER, Spector TD, Wright WE, Shay JW. Decreasing initial telomere length in humans intergenerationally understates age-associated telomere shortening. Aging Cell. PMID 25952108 DOI: 10.1111/acel.12347  1
2015 Kulak O, Chen H, Holohan B, Wu X, He H, Borek D, Otwinowski Z, Yamaguchi K, Garofalo LA, Ma Z, Wright W, Chen C, Shay JW, Zhang X, Lum L. Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells. Molecular and Cellular Biology. 35: 2425-35. PMID 25939383 DOI: 10.1128/MCB.00392-15  1
2015 LaConti JJ, Laiakis EC, Mays AD, Peran I, Kim SE, Shay JW, Riegel AT, Fornace AJ, Wellstein A. Distinct serum metabolomics profiles associated with malignant progression in the KrasG12D mouse model of pancreatic ductal adenocarcinoma. Bmc Genomics. 16: S1. PMID 25923219 DOI: 10.1186/1471-2164-16-S1-S1  1
2015 Zhang L, Kim S, Jia G, Buhmeida A, Dallol A, Wright WE, Fornace AJ, Al-Qahtani M, Shay JW. Exome Sequencing of Normal and Isogenic Transformed Human Colonic Epithelial Cells (HCECs) Reveals Novel Genes Potentially Involved in the Early Stages of Colorectal Tumorigenesis. Bmc Genomics. 16: S8. PMID 25923178 DOI: 10.1186/1471-2164-16-S1-S8  1
2015 Stuart BD, Choi J, Zaidi S, Xing C, Holohan B, Chen R, Choi M, Dharwadkar P, Torres F, Girod CE, Weissler J, Fitzgerald J, Kershaw C, Klesney-Tait J, Mageto Y, ... Shay JW, et al. Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening. Nature Genetics. 47: 512-7. PMID 25848748 DOI: 10.1038/ng.3278  1
2015 Pandita RK, Chow TT, Udayakumar D, Bain AL, Cubeddu L, Hunt CR, Shi W, Horikoshi N, Zhao Y, Wright WE, Khanna KK, Shay JW, Pandita TK. Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs. Cancer Research. 75: 858-69. PMID 25589350 DOI: 10.1158/0008-5472.CAN-14-2289  1
2015 Mender I, Gryaznov S, Dikmen ZG, Wright WE, Shay JW. Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine. Cancer Discovery. 5: 82-95. PMID 25516420 DOI: 10.1158/2159-8290.CD-14-0609  1
2015 Hosler GA, Davoli T, Mender I, Litzner B, Choi J, Kapur P, Shay JW, Wang RC. A primary melanoma and its asynchronous metastasis highlight the role of BRAF, CDKN2A, and TERT. Journal of Cutaneous Pathology. 42: 108-17. PMID 25407517 DOI: 10.1111/cup.12444  1
2015 Shay JW, Wright WE. Telomerase: Target for cancer treatment Molecular Oncology: Causes of Cancer and Targets For Treatment. 442-451. DOI: 10.1017/CBO9781139046947.038  1
2015 Holohan B, Hagiopian MM, Lai TP, Huang E, Friedman DR, Wright WE, Shay JW. Perifosine as a potential novel anti-telomerase therapy Oncotarget. 6: 21816-21826.  1
2014 Kim SB, Zhang L, Barron S, Shay JW. Inhibition of microRNA-31-5p protects human colonic epithelial cells against ionizing radiation. Life Sciences in Space Research. 1: 67-73. PMID 26432591 DOI: 10.1016/j.lssr.2014.02.001  1
2014 El-Ashmawy M, Delgado O, Cardentey A, Wright WE, Shay JW. CDDO-Me protects normal lung and breast epithelial cells but not cancer cells from radiation. Plos One. 9: e115600. PMID 25536195 DOI: 10.1371/journal.pone.0115600  1
2014 Robin JD, Ludlow AT, Batten K, Magdinier F, Stadler G, Wagner KR, Shay JW, Wright WE. Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances. Genes & Development. 28: 2464-76. PMID 25403178 DOI: 10.1101/gad.251041.114  1
2014 Wong MS, Wright WE, Shay JW. Alternative splicing regulation of telomerase: a new paradigm? Trends in Genetics : Tig. 30: 430-8. PMID 25172021 DOI: 10.1016/j.tig.2014.07.006  1
2014 Shao C, Sullivan JP, Girard L, Augustyn A, Yenerall P, Rodriguez-Canales J, Liu H, Behrens C, Shay JW, Wistuba II, Minna JD. Essential role of aldehyde dehydrogenase 1A3 for the maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 4154-66. PMID 24907115 DOI: 10.1158/1078-0432.CCR-13-3292  1
2014 Ludlow AT, Robin JD, Sayed M, Litterst CM, Shelton DN, Shay JW, Wright WE. Quantitative telomerase enzyme activity determination using droplet digital PCR with single cell resolution. Nucleic Acids Research. 42: e104. PMID 24861623 DOI: 10.1093/nar/gku439  1
2014 Kaisani A, Delgado O, Fasciani G, Kim SB, Wright WE, Minna JD, Shay JW. Branching morphogenesis of immortalized human bronchial epithelial cells in three-dimensional culture. Differentiation; Research in Biological Diversity. 87: 119-26. PMID 24830354 DOI: 10.1016/j.diff.2014.02.003  1
2014 Holohan B, Wright WE, Shay JW. Cell biology of disease: Telomeropathies: an emerging spectrum disorder. The Journal of Cell Biology. 205: 289-99. PMID 24821837 DOI: 10.1083/jcb.201401012  1
2014 Farooqi AS, Dagg RA, Choi LM, Shay JW, Reynolds CP, Lau LM. Alternative lengthening of telomeres in neuroblastoma cell lines is associated with a lack of MYCN genomic amplification and with p53 pathway aberrations. Journal of Neuro-Oncology. 119: 17-26. PMID 24792489 DOI: 10.1007/s11060-014-1456-8  1
2014 Singel SM, Cornelius C, Zaganjor E, Batten K, Sarode VR, Buckley DL, Peng Y, John GB, Li HC, Sadeghi N, Wright WE, Lum L, Corson TW, Shay JW. KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer. Neoplasia (New York, N.Y.). 16: 247-56, 256.e2. PMID 24784001 DOI: 10.1016/j.neo.2014.03.008  1
2014 Singel SM, Batten K, Cornelius C, Jia G, Fasciani G, Barron SL, Wright WE, Shay JW. Receptor-interacting protein kinase 2 promotes triple-negative breast cancer cell migration and invasion via activation of nuclear factor-kappaB and c-Jun N-terminal kinase pathways. Breast Cancer Research : Bcr. 16: R28. PMID 24642040 DOI: 10.1186/bcr3629  1
2014 Wong MS, Shay JW, Wright WE. Regulation of human telomerase splicing by RNA:RNA pairing. Nature Communications. 5: 3306. PMID 24577044 DOI: 10.1038/ncomms4306  1
2014 Uzozie A, Nanni P, Staiano T, Grossmann J, Barkow-Oesterreicher S, Shay JW, Tiwari A, Buffoli F, Laczko E, Marra G. Sorbitol dehydrogenase overexpression and other aspects of dysregulated protein expression in human precancerous colorectal neoplasms: a quantitative proteomics study. Molecular & Cellular Proteomics : McP. 13: 1198-218. PMID 24567419 DOI: 10.1074/mcp.M113.035105  1
2014 Delgado O, Batten KG, Richardson JA, Xie XJ, Gazdar AF, Kaisani AA, Girard L, Behrens C, Suraokar M, Fasciani G, Wright WE, Story MD, Wistuba II, Minna JD, Shay JW. Radiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 1610-22. PMID 24486591 DOI: 10.1158/1078-0432.CCR-13-2589  1
2014 Ng WL, Chen G, Wang M, Wang H, Story M, Shay JW, Zhang X, Wang J, Amin AR, Hu B, Cucinotta FA, Wang Y. OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation. Cell Death & Disease. 5: e1024. PMID 24457968 DOI: 10.1038/cddis.2013.563  1
2014 Constantinescu S, Hecht K, Sobotzki N, Erzinger MM, Bovet C, Shay JW, Wollscheid B, Sturla SJ, Marra G, Beerenwinkel N. Transcriptomic responses of cancerous and noncancerous human colon cells to sulforaphane and selenium. Chemical Research in Toxicology. 27: 377-86. PMID 24383545 DOI: 10.1021/tx400427t  1
2014 Shay JW. Are short telomeres hallmarks of cancer recurrence? Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 779-81. PMID 24366690 DOI: 10.1158/1078-0432.CCR-13-3198  1
2014 Grant JL, Fishbein MC, Hong LS, Krysan K, Minna JD, Shay JW, Walser TC, Dubinett SM. A novel molecular pathway for Snail-dependent, SPARC-mediated invasion in non-small cell lung cancer pathogenesis. Cancer Prevention Research (Philadelphia, Pa.). 7: 150-60. PMID 24253315 DOI: 10.1158/1940-6207.CAPR-13-0263  1
2014 Zhou J, Mao B, Zhou Q, Ding D, Wang M, Guo P, Gao Y, Shay JW, Yuan Z, Cong YS. Endoplasmic reticulum stress activates telomerase. Aging Cell. 13: 197-200. PMID 24119029 DOI: 10.1111/acel.12161  1
2013 Stadler G, King OD, Robin JD, Shay JW, Wright WE. Facioscapulohumeral muscular dystrophy: Are telomeres the end of the story? Rare Diseases (Austin, Tex.). 1: e26142. PMID 25003004 DOI: 10.4161/rdis.26142  0.72
2013 Shay JW. Are short telomeres predictive of advanced cancer? Cancer Discovery. 3: 1096-8. PMID 24124228 DOI: 10.1158/2159-8290.CD-13-0506  1
2013 Kim SB, Ly P, Kaisani A, Zhang L, Wright WE, Shay JW. Mitigation of radiation-induced damage by targeting EGFR in noncancerous human epithelial cells. Radiation Research. 180: 259-67. PMID 23919312 DOI: 10.1667/RR3371.1  1
2013 Shay JW. Determining if telomeres matter in colon cancer initiation or progression. Journal of the National Cancer Institute. 105: 1166-8. PMID 23918446 DOI: 10.1093/jnci/djt200  1
2013 Ghayee HK, Giubellino A, Click A, Kapur P, Christie A, Xie XJ, Martucci V, Shay JW, Souza RF, Pacak K. Phospho-mTOR is not upregulated in metastatic SDHB paragangliomas. European Journal of Clinical Investigation. 43: 970-7. PMID 23889685 DOI: 10.1111/eci.12127  1
2013 Ghayee HK, Bhagwandin VJ, Stastny V, Click A, Ding LH, Mizrachi D, Zou YS, Chari R, Lam WL, Bachoo RM, Smith AL, Story MD, Sidhu S, Robinson BG, Nwariaku FE, ... ... Shay JW, et al. Progenitor cell line (hPheo1) derived from a human pheochromocytoma tumor. Plos One. 8: e65624. PMID 23785438 DOI: 10.1371/journal.pone.0065624  1
2013 Stadler G, Rahimov F, King OD, Chen JC, Robin JD, Wagner KR, Shay JW, Emerson CP, Wright WE. Telomere position effect regulates DUX4 in human facioscapulohumeral muscular dystrophy. Nature Structural & Molecular Biology. 20: 671-8. PMID 23644600 DOI: 10.1038/nsmb.2571  1
2013 Wong MS, Chen L, Foster C, Kainthla R, Shay JW, Wright WE. Regulation of telomerase alternative splicing: a target for chemotherapy. Cell Reports. 3: 1028-35. PMID 23562158 DOI: 10.1016/j.celrep.2013.03.011  1
2013 Mender I, Senturk S, Ozgunes N, Akcali KC, Kletsas D, Gryaznov S, Can A, Shay JW, Dikmen ZG. Imetelstat (a telomerase antagonist) exerts off‑target effects on the cytoskeleton. International Journal of Oncology. 42: 1709-15. PMID 23545855 DOI: 10.3892/ijo.2013.1865  1
2013 Singel SM, Cornelius C, Batten K, Fasciani G, Wright WE, Lum L, Shay JW. A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 2061-70. PMID 23479679 DOI: 10.1158/1078-0432.CCR-13-0082  1
2013 Sato M, Larsen JE, Lee W, Sun H, Shames DS, Dalvi MP, Ramirez RD, Tang H, DiMaio JM, Gao B, Xie Y, Wistuba II, Gazdar AF, Shay JW, Minna JD. Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations. Molecular Cancer Research : McR. 11: 638-50. PMID 23449933 DOI: 10.1158/1541-7786.MCR-12-0634-T  1
2013 Christodoulidou A, Raftopoulou C, Chiourea M, Papaioannou GK, Hoshiyama H, Wright WE, Shay JW, Gagos S. The roles of telomerase in the generation of polyploidy during neoplastic cell growth. Neoplasia (New York, N.Y.). 15: 156-68. PMID 23441130 DOI: 10.1593/neo.121398  1
2013 Gupta A, Hunt CR, Pandita RK, Pae J, Komal K, Singh M, Shay JW, Kumar R, Ariizumi K, Horikoshi N, Hittelman WN, Guha C, Ludwig T, Pandita TK. T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice. Mutagenesis. 28: 263-70. PMID 23386701 DOI: 10.1093/mutage/ges080  1
2013 Hunt CR, Ramnarain D, Horikoshi N, Iyengar P, Pandita RK, Shay JW, Pandita TK. Histone modifications and DNA double-strand break repair after exposure to ionizing radiations. Radiation Research. 179: 383-92. PMID 23373901 DOI: 10.1667/RR3308.2  1
2013 Singh M, Hunt CR, Pandita RK, Kumar R, Yang CR, Horikoshi N, Bachoo R, Serag S, Story MD, Shay JW, Powell SN, Gupta A, Jeffery J, Pandita S, Chen BP, et al. Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest. Molecular and Cellular Biology. 33: 1210-22. PMID 23319047 DOI: 10.1128/MCB.01676-12  1
2013 Ly P, Kim SB, Kaisani AA, Marian G, Wright WE, Shay JW. Aneuploid human colonic epithelial cells are sensitive to AICAR-induced growth inhibition through EGFR degradation. Oncogene. 32: 3139-46. PMID 22890317 DOI: 10.1038/onc.2012.339  1
2013 Zhang L, Komurov K, Wright WE, Shay JW. Identification of novel driver tumor suppressors through functional interrogation of putative passenger mutations in colorectal cancer. International Journal of Cancer. Journal International Du Cancer. 132: 732-7. PMID 22753261 DOI: 10.1002/ijc.27705  1
2012 Campregher C, Schmid G, Ferk F, Knasmüller S, Khare V, Kortüm B, Dammann K, Lang M, Scharl T, Spittler A, Roig AI, Shay JW, Gerner C, Gasche C. MSH3-deficiency initiates EMAST without oncogenic transformation of human colon epithelial cells. Plos One. 7: e50541. PMID 23209772 DOI: 10.1371/journal.pone.0050541  1
2012 Kim SB, Pandita RK, Eskiocak U, Ly P, Kaisani A, Kumar R, Cornelius C, Wright WE, Pandita TK, Shay JW. Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation. Proceedings of the National Academy of Sciences of the United States of America. 109: E2949-55. PMID 23045680 DOI: 10.1073/pnas.1207718109  1
2012 Ly P, Eskiocak U, Parker CR, Harris KJ, Wright WE, Shay JW. RNAi screening of the human colorectal cancer genome identifies multifunctional tumor suppressors regulating epithelial cell invasion. Cell Research. 22: 1605-8. PMID 23044803 DOI: 10.1038/cr.2012.140  1
2012 Shay JW, Reddel RR, Wright WE. Cancer. Cancer and telomeres--an ALTernative to telomerase. Science (New York, N.Y.). 336: 1388-90. PMID 22700908 DOI: 10.1126/science.1222394  1
2012 Chow TT, Zhao Y, Mak SS, Shay JW, Wright WE. Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shortening. Genes & Development. 26: 1167-78. PMID 22661228 DOI: 10.1101/gad.187211.112  1
2012 Hoshiyama H, Tang J, Batten K, Xiao G, Rouillard JM, Shay JW, Xie Y, Wright WE. Development of methods for quantitative comparison of pooled shRNAs by mass sequencing. Journal of Biomolecular Screening. 17: 258-65. PMID 21956173 DOI: 10.1177/1087057111423101  1
2012 Buseman CM, Wright WE, Shay JW. Is telomerase a viable target in cancer? Mutation Research. 730: 90-7. PMID 21802433 DOI: 10.1016/j.mrfmmm.2011.07.006  1
2012 Smiraldo PG, Tang J, Shay JW, Wright WE. Cellular Senescence, Telomerase, and Cancer in Human Cells Telomerases: Chemistry, Biology, and Clinical Applications. 243-263. DOI: 10.1002/9781118268667.ch10  1
2011 Kim J, Eskiocak U, Stadler G, Lou Z, Kuro-o M, Shay JW, Wright WE. Short hairpin RNA screen indicates that Klotho beta/FGF19 protein overcomes stasis in human colonic epithelial cells. The Journal of Biological Chemistry. 286: 43294-300. PMID 22020932 DOI: 10.1074/jbc.M111.267641  1
2011 Shay JW, Wright WE. Role of telomeres and telomerase in cancer. Seminars in Cancer Biology. 21: 349-53. PMID 22015685 DOI: 10.1016/j.semcancer.2011.10.001  1
2011 Shay JW, Cucinotta FA, Sulzman FM, Coleman CN, Minna JD. From mice and men to earth and space: joint NASA-NCI workshop on lung cancer risk resulting from space and terrestrial radiation. Cancer Research. 71: 6926-9. PMID 21900398 DOI: 10.1158/0008-5472.CAN-11-2546  1
2011 Stadler G, Chen JC, Wagner K, Robin JD, Shay JW, Emerson CP, Wright WE. Establishment of clonal myogenic cell lines from severely affected dystrophic muscles - CDK4 maintains the myogenic population. Skeletal Muscle. 1: 12. PMID 21798090 DOI: 10.1186/2044-5040-1-12  1
2011 Delgado O, Kaisani AA, Spinola M, Xie XJ, Batten KG, Minna JD, Wright WE, Shay JW. Multipotent capacity of immortalized human bronchial epithelial cells. Plos One. 6: e22023. PMID 21760947 DOI: 10.1371/journal.pone.0022023  1
2011 Wang H, Venkatesh M, Li H, Goetz R, Mukherjee S, Biswas A, Zhu L, Kaubisch A, Wang L, Pullman J, Whitney K, Kuro-o M, Roig AI, Shay JW, Mohammadi M, et al. Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice. The Journal of Clinical Investigation. 121: 3220-32. PMID 21747170 DOI: 10.1172/JCI41514  1
2011 Zhao Y, Abreu E, Kim J, Stadler G, Eskiocak U, Terns MP, Terns RM, Shay JW, Wright WE. Processive and distributive extension of human telomeres by telomerase under homeostatic and nonequilibrium conditions. Molecular Cell. 42: 297-307. PMID 21549308 DOI: 10.1016/j.molcel.2011.03.020  1
2011 Eskiocak U, Kim SB, Ly P, Roig AI, Biglione S, Komurov K, Cornelius C, Wright WE, White MA, Shay JW. Functional parsing of driver mutations in the colorectal cancer genome reveals numerous suppressors of anchorage-independent growth. Cancer Research. 71: 4359-65. PMID 21527559 DOI: 10.1158/0008-5472.CAN-11-0794  1
2011 Gomes NM, Ryder OA, Houck ML, Charter SJ, Walker W, Forsyth NR, Austad SN, Venditti C, Pagel M, Shay JW, Wright WE. Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination. Aging Cell. 10: 761-8. PMID 21518243 DOI: 10.1111/j.1474-9726.2011.00718.x  1
2011 Ly P, Eskiocak U, Kim SB, Roig AI, Hight SK, Lulla DR, Zou YS, Batten K, Wright WE, Shay JW. Characterization of aneuploid populations with trisomy 7 and 20 derived from diploid human colonic epithelial cells. Neoplasia (New York, N.Y.). 13: 348-57. PMID 21472139 DOI: 10.1593/neo.101580  1
2011 Zhao Y, Shay JW, Wright WE. Telomere terminal G/C strand synthesis: measuring telomerase action and C-rich fill-in. Methods in Molecular Biology (Clifton, N.J.). 735: 63-75. PMID 21461812 DOI: 10.1007/978-1-61779-092-8_7  1
2011 Zhao Y, Shay JW, Wright WE. Telomere G-overhang length measurement method 1: the DSN method. Methods in Molecular Biology (Clifton, N.J.). 735: 47-54. PMID 21461810 DOI: 10.1007/978-1-61779-092-8_5  1
2011 Asaithamby A, Hu B, Delgado O, Ding LH, Story MD, Minna JD, Shay JW, Chen DJ. Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture. Nucleic Acids Research. 39: 5474-88. PMID 21421565 DOI: 10.1093/nar/gkr149  1
2011 Ouellette MM, Wright WE, Shay JW. Targeting telomerase-expressing cancer cells. Journal of Cellular and Molecular Medicine. 15: 1433-42. PMID 21332640 DOI: 10.1111/j.1582-4934.2011.01279.x  1
2011 Kumar R, Hunt CR, Gupta A, Nannepaga S, Pandita RK, Shay JW, Bachoo R, Ludwig T, Burns DK, Pandita TK. Purkinje cell-specific males absent on the first (mMof) gene deletion results in an ataxia-telangiectasia-like neurological phenotype and backward walking in mice. Proceedings of the National Academy of Sciences of the United States of America. 108: 3636-41. PMID 21321203 DOI: 10.1073/pnas.1016524108  1
2011 Marian CO, Yang L, Zou YS, Gore C, Pong RC, Shay JW, Kabbani W, Hsieh JT, Raj GV. Evidence of epithelial to mesenchymal transition associated with increased tumorigenic potential in an immortalized normal prostate epithelial cell line. The Prostate. 71: 626-36. PMID 20945502 DOI: 10.1002/pros.21278  1
2010 Sullivan JP, Spinola M, Dodge M, Raso MG, Behrens C, Gao B, Schuster K, Shao C, Larsen JE, Sullivan LA, Honorio S, Xie Y, Scaglioni PP, DiMaio JM, Gazdar AF, ... Shay JW, et al. Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer Research. 70: 9937-48. PMID 21118965 DOI: 10.1158/0008-5472.CAN-10-0881  1
2010 Joseph I, Tressler R, Bassett E, Harley C, Buseman CM, Pattamatta P, Wright WE, Shay JW, Go NF. The telomerase inhibitor imetelstat depletes cancer stem cells in breast and pancreatic cancer cell lines. Cancer Research. 70: 9494-504. PMID 21062983 DOI: 10.1158/0008-5472.CAN-10-0233  1
2010 Shultz JC, Goehe RW, Wijesinghe DS, Murudkar C, Hawkins AJ, Shay JW, Minna JD, Chalfant CE. Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a. Cancer Research. 70: 9185-96. PMID 21045158 DOI: 10.1158/0008-5472.CAN-10-1545  1
2010 Goehe RW, Shultz JC, Murudkar C, Usanovic S, Lamour NF, Massey DH, Zhang L, Camidge DR, Shay JW, Minna JD, Chalfant CE. hnRNP L regulates the tumorigenic capacity of lung cancer xenografts in mice via caspase-9 pre-mRNA processing. The Journal of Clinical Investigation. 120: 3923-39. PMID 20972334 DOI: 10.1172/JCI43552  1
2010 Eskiocak U, Kim SB, Roig AI, Kitten E, Batten K, Cornelius C, Zou YS, Wright WE, Shay JW. CDDO-Me protects against space radiation-induced transformation of human colon epithelial cells. Radiation Research. 174: 27-36. PMID 20681796 DOI: 10.1667/RR2155.1  1
2010 Gomes NM, Shay JW, Wright WE. Telomere biology in Metazoa. Febs Letters. 584: 3741-51. PMID 20655915 DOI: 10.1016/j.febslet.2010.07.031  1
2010 Shay JW, Wright WE. Telomeres and telomerase in normal and cancer stem cells. Febs Letters. 584: 3819-25. PMID 20493857 DOI: 10.1016/j.febslet.2010.05.026  1
2010 Roig AI, Hight SK, Minna JD, Shay JW, Rusek A, Story MD. DNA damage intensity in fibroblasts in a 3-dimensional collagen matrix correlates with the Bragg curve energy distribution of a high LET particle. International Journal of Radiation Biology. 86: 194-204. PMID 20201648 DOI: 10.3109/09553000903418603  1
2010 Chakravarti N, Kadara H, Yoon DJ, Shay JW, Myers JN, Lotan D, Sonenberg N, Lotan R. Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells. Cancer Prevention Research (Philadelphia, Pa.). 3: 331-8. PMID 20145189 DOI: 10.1158/1940-6207.CAPR-09-0076  1
2010 Sullivan JP, Minna JD, Shay JW. Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy. Cancer Metastasis Reviews. 29: 61-72. PMID 20094757 DOI: 10.1007/s10555-010-9216-5  1
2010 Marian CO, Cho SK, McEllin BM, Maher EA, Hatanpaa KJ, Madden CJ, Mickey BE, Wright WE, Shay JW, Bachoo RM. The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 154-63. PMID 20048334 DOI: 10.1158/1078-0432.CCR-09-2850  1
2010 Li Y, Malaeb BS, Li ZZ, Thompson MG, Chen Z, Corey DR, Hsieh JT, Shay JW, Koeneman KS. Telomerase enzyme inhibition (TEI) and cytolytic therapy in the management of androgen independent osseous metastatic prostate cancer. The Prostate. 70: 616-29. PMID 20043297 DOI: 10.1002/pros.21096  1
2010 Roig AI, Eskiocak U, Hight SK, Kim SB, Delgado O, Souza RF, Spechler SJ, Wright WE, Shay JW. Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro. Gastroenterology. 138: 1012-21.e1-5. PMID 19962984 DOI: 10.1053/j.gastro.2009.11.052  1
2010 Atzmon G, Cho M, Cawthon RM, Budagov T, Katz M, Yang X, Siegel G, Bergman A, Huffman DM, Schechter CB, Wright WE, Shay JW, Barzilai N, Govindaraju DR, Suh Y. Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proceedings of the National Academy of Sciences of the United States of America. 107: 1710-7. PMID 19915151 DOI: 10.1073/pnas.0906191106  1
2010 Marian CO, Wright WE, Shay JW. The effects of telomerase inhibition on prostate tumor-initiating cells. International Journal of Cancer. Journal International Du Cancer. 127: 321-31. PMID 19908230 DOI: 10.1002/ijc.25043  1
2009 Lou Z, Wei J, Riethman H, Baur JA, Voglauer R, Shay JW, Wright WE. Telomere length regulates ISG15 expression in human cells. Aging. 1: 608-21. PMID 20157543  1
2009 Vaughan MB, Ramirez RD, Andrews CM, Wright WE, Shay JW. H-ras expression in immortalized keratinocytes produces an invasive epithelium in cultured skin equivalents. Plos One. 4: e7908. PMID 19936293 DOI: 10.1371/journal.pone.0007908  1
2009 Yoon H, Kim DJ, Ahn EH, Gellert GC, Shay JW, Ahn CH, Lee YB. Antitumor activity of a novel antisense oligonucleotide against Akt1. Journal of Cellular Biochemistry. 108: 832-8. PMID 19693774 DOI: 10.1002/jcb.22311  1
2009 Zhao Y, Sfeir AJ, Zou Y, Buseman CM, Chow TT, Shay JW, Wright WE. Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells. Cell. 138: 463-75. PMID 19665970 DOI: 10.1016/j.cell.2009.05.026  1
2009 Walker RF, Pakula LC, Sutcliffe MJ, Kruk PA, Graakjaer J, Shay JW. A case study of "disorganized development" and its possible relevance to genetic determinants of aging. Mechanisms of Ageing and Development. 130: 350-6. PMID 19428454 DOI: 10.1016/j.mad.2009.02.003  1
2009 Matsuo T, Shay JW, Wright WE, Hiyama E, Shimose S, Kubo T, Sugita T, Yasunaga Y, Ochi M. Telomere-maintenance mechanisms in soft-tissue malignant fibrous histiocytomas. The Journal of Bone and Joint Surgery. American Volume. 91: 928-37. PMID 19339578 DOI: 10.2106/JBJS.G.01390  1
2009 Marian CO, Shay JW. Prostate tumor-initiating cells: a new target for telomerase inhibition therapy? Biochimica Et Biophysica Acta. 1792: 289-96. PMID 19264126 DOI: 10.1016/j.bbadis.2009.02.012  1
2009 Bhagwandin VJ, Shay JW. Pancreatic cancer stem cells: fact or fiction? Biochimica Et Biophysica Acta. 1792: 248-59. PMID 19233264 DOI: 10.1016/j.bbadis.2009.02.007  1
2009 Zou Y, Misri S, Shay JW, Pandita TK, Wright WE. Altered states of telomere deprotection and the two-stage mechanism of replicative aging. Molecular and Cellular Biology. 29: 2390-7. PMID 19223460 DOI: 10.1128/MCB.01569-08  1
2009 Roig AI, Hight SK, Shay JW. Two- and three-dimensional models for risk assessment of radiation-enhanced colorectal tumorigenesis. Radiation Research. 171: 33-40. PMID 19138051 DOI: 10.1667/RR1415.1  1
2009 Roig AI, Wright WE, Shay JW. Is telomerase a novel target for metastatic colon cancer? Current Colorectal Cancer Reports. 5: 203-208. DOI: 10.1007/s11888-009-0028-3  1
2008 Zhu CH, Kim J, Shay JW, Wright WE. SGNP: an essential Stress Granule/Nucleolar Protein potentially involved in 5.8s rRNA processing/transport. Plos One. 3: e3716. PMID 19005571 DOI: 10.1371/journal.pone.0003716  1
2008 Gagos S, Chiourea M, Christodoulidou A, Apostolou E, Raftopoulou C, Deustch S, Jefford CE, Irminger-Finger I, Shay JW, Antonarakis SE. Pericentromeric instability and spontaneous emergence of human neoacrocentric and minute chromosomes in the alternative pathway of telomere lengthening. Cancer Research. 68: 8146-55. PMID 18829574 DOI: 10.1158/0008-5472.CAN-08-0945  1
2008 Cong Y, Shay JW. Actions of human telomerase beyond telomeres. Cell Research. 18: 725-32. PMID 18574498 DOI: 10.1038/cr.2008.74  1
2008 Dikmen ZG, Gellert GC, Dogan P, Yoon H, Lee YB, Ahn CH, Shay JW. In vivo and in vitro effects of a HIF-1alpha inhibitor, RX-0047. Journal of Cellular Biochemistry. 104: 985-94. PMID 18275063 DOI: 10.1002/jcb.21681  1
2008 Shay JW, Keith WN. Targeting telomerase for cancer therapeutics. British Journal of Cancer. 98: 677-83. PMID 18231105 DOI: 10.1038/sj.bjc.6604209  1
2008 Sarosi G, Brown G, Jaiswal K, Feagins LA, Lee E, Crook TW, Souza RF, Zou YS, Shay JW, Spechler SJ. Bone marrow progenitor cells contribute to esophageal regeneration and metaplasia in a rat model of Barrett's esophagus Diseases of the Esophagus. 21: 43-50. PMID 18197938 DOI: 10.1111/j.1442-2050.2007.00744.x  1
2008 Zhao Y, Hoshiyama H, Shay JW, Wright WE. Quantitative telomeric overhang determination using a double-strand specific nuclease. Nucleic Acids Research. 36: e14. PMID 18073199 DOI: 10.1093/nar/gkm1063  1
2008 Dikmen ZG, Wright WE, Shay JW, Gryaznov SM. Telomerase targeted oligonucleotide thio-phosphoramidates in T24-luc bladder cancer cells. Journal of Cellular Biochemistry. 104: 444-52. PMID 18044713 DOI: 10.1002/jcb.21635  1
2008 Pearce VP, Sherrell J, Lou Z, Kopelovich L, Wright WE, Shay JW. Immortalization of epithelial progenitor cells mediated by resveratrol. Oncogene. 27: 2365-74. PMID 17968319 DOI: 10.1038/sj.onc.1210886  1
2008 Shay JW, Rudolph KL. Introduction Telomeres and Telomerase in Ageing, Disease, and Cancer: Molecular Mechanisms of Adult Stem Cell Ageing. xi-xiv. DOI: 10.1007/978-3-540-73709-4  1
2007 Natarajan S, Chow TT, Shay JW, Wright WE. Replica plating of mammalian cells using low melt agarose. Cytotechnology. 54: 145-7. PMID 19003006 DOI: 10.1007/s10616-007-9071-6  1
2007 Gryaznov SM, Jackson S, Dikmen G, Harley C, Herbert BS, Wright WE, Shay JW. Oligonucleotide conjugate GRN163L targeting human telomerase as potential anticancer and antimetastatic agent. Nucleosides, Nucleotides & Nucleic Acids. 26: 1577-9. PMID 18066830 DOI: 10.1080/15257770701547271  1
2007 Garcia CK, Wright WE, Shay JW. Human diseases of telomerase dysfunction: insights into tissue aging. Nucleic Acids Research. 35: 7406-16. PMID 17913752 DOI: 10.1093/nar/gkm644  1
2007 Keith WN, Thomson CM, Howcroft J, Maitland NJ, Shay JW. Seeding drug discovery: integrating telomerase cancer biology and cellular senescence to uncover new therapeutic opportunities in targeting cancer stem cells Drug Discovery Today. 12: 611-621. PMID 17706542 DOI: 10.1016/j.drudis.2007.06.009  1
2007 Padrón D, Sato M, Shay JW, Gazdar AF, Minna JD, Roth MG. Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized Cancer Research. 67: 7695-7702. PMID 17699773 DOI: 10.1158/0008-5472.CAN-07-0484  1
2007 Shay JW, Wright WE. Tissue culture as a hostile environment: identifying conditions for breast cancer progression studies. Cancer Cell. 12: 100-1. PMID 17692800 DOI: 10.1016/j.ccr.2007.07.012  1
2007 Liu M, Yang SC, Sharma S, Luo J, Cui X, Peebles KA, Huang M, Sato M, Ramirez RD, Shay JW, Minna JD, Dubinett SM. EGFR signaling is required for TGF-β1-mediated COX-2 induction in human bronchial epithelial cells American Journal of Respiratory Cell and Molecular Biology. 37: 578-588. PMID 17600311 DOI: 10.1165/rcmb.2007-0100OC  1
2007 Zhu CH, Mouly V, Cooper RN, Mamchaoui K, Bigot A, Shay JW, Di Santo JP, Butler-Browne GS, Wright WE. Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies. Aging Cell. 6: 515-23. PMID 17559502 DOI: 10.1111/j.1474-9726.2007.00306.x  1
2007 Lam DC, Girard L, Ramirez R, Chau WS, Suen WS, Sheridan S, Tin VP, Chung LP, Wong MP, Shay JW, Gazdar AF, Lam WK, Minna JD. Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers. Cancer Research. 67: 4638-47. PMID 17510389 DOI: 10.1158/0008-5472.CAN-06-4628  1
2007 Tsakiri KD, Cronkhite JT, Kuan PJ, Xing C, Raghu G, Weissler JC, Rosenblatt RL, Shay JW, Garcia CK. Adult-onset pulmonary fibrosis caused by mutations in telomerase Proceedings of the National Academy of Sciences of the United States of America. 104: 7552-7557. PMID 17460043 DOI: 10.1073/pnas.0701009104  1
2007 Nomura M, Shigematsu H, Li L, Suzuki M, Takahashi T, Estess P, Siegelman M, Feng Z, Kato H, Marchetti A, Shay JW, Spitz MR, Wistuba II, Minna JD, Gazdar AF. Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers Plos Medicine. 4: 715-727. PMID 17455987 DOI: 10.1371/journal.pmed.0040125  1
2007 Gardner JP, Kimura M, Chai W, Durrani JF, Tchakmakjian L, Cao X, Lu X, Li G, Peppas AP, Skurnick J, Wright WE, Shay JW, Aviv A. Telomere dynamics in macaques and humans. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 62: 367-74. PMID 17452729  1
2007 Souza RF, Lunsford T, Ramirez RD, Zhang X, Lee EL, Shen Y, Owen C, Shay JW, Morales C, Spechler SJ. GERD is associated with shortened telomeres in the squamous epithelium of the distal esophagus. American Journal of Physiology. Gastrointestinal and Liver Physiology. 293: G19-24. PMID 17395902 DOI: 10.1152/ajpgi.00055.2007  1
2007 Jackson SR, Zhu CH, Paulson V, Watkins L, Dikmen ZG, Gryaznov SM, Wright WE, Shay JW. Antiadhesive effects of GRN163L--an oligonucleotide N3'->P5' thio-phosphoramidate targeting telomerase. Cancer Research. 67: 1121-9. PMID 17283146 DOI: 10.1158/0008-5472.CAN-06-2306  1
2007 Shay JW, Wright WE. Hallmarks of telomeres in ageing research. The Journal of Pathology. 211: 114-23. PMID 17200948 DOI: 10.1002/path.2090  1
2006 Wright WE, Shay JW. Inexpensive low-oxygen incubators. Nature Protocols. 1: 2088-90. PMID 17487199 DOI: 10.1038/nprot.2006.374  1
2006 Herbert BS, Hochreiter AE, Wright WE, Shay JW. Nonradioactive detection of telomerase activity using the telomeric repeat amplification protocol. Nature Protocols. 1: 1583-90. PMID 17406450 DOI: 10.1038/nprot.2006.239  1
2006 Shames DS, Girard L, Gao B, Sato M, Lewis CM, Shivapurkar N, Jiang A, Perou CM, Kim YH, Pollack JR, Fong KM, Lam CL, Wong M, Shyr Y, Nanda R, ... ... Shay JW, et al. A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies. Plos Medicine. 3: e486. PMID 17194187 DOI: 10.1371/journal.pmed.0030486  1
2006 Das AK, Sato M, Story MD, Peyton M, Graves R, Redpath S, Girard L, Gazdar AF, Shay JW, Minna JD, Nirodi CS. Non-small-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation. Cancer Research. 66: 9601-8. PMID 17018617 DOI: 10.1158/0008-5472.CAN-06-2627  1
2006 Shay JW, Wright WE. Telomerase therapeutics for cancer: challenges and new directions. Nature Reviews. Drug Discovery. 5: 577-84. PMID 16773071 DOI: 10.1038/nrd2081  1
2006 Vaughan MB, Ramirez RD, Wright WE, Minna JD, Shay JW. A three-dimensional model of differentiation of immortalized human bronchial epithelial cells. Differentiation; Research in Biological Diversity. 74: 141-8. PMID 16683984 DOI: 10.1111/j.1432-0436.2006.00069.x  1
2006 Finkel T, Vijg J, Shay JW. Time, tumours and telomeres: Meeting on cancer and aging Embo Reports. 7: 479-483. PMID 16641934 DOI: 10.1038/sj.embor.7400680  1
2006 Liu Z, Widlak P, Zou Y, Xiao F, Oh M, Li S, Chang MY, Shay JW, Garrard WT. A recombination silencer that specifies heterochromatin positioning and ikaros association in the immunoglobulin kappa locus. Immunity. 24: 405-15. PMID 16618599 DOI: 10.1016/j.immuni.2006.02.001  1
2006 Lewis CM, Herbert BS, Bu D, Halloway S, Beck A, Shadeo A, Zhang C, Ashfaq R, Shay JW, Euhus DM. Telomerase immortalization of human mammary epithelial cells derived from a BRCA2 mutation carrier Breast Cancer Research and Treatment. 99: 103-115. PMID 16541310 DOI: 10.1007/s10549-006-9189-9  1
2006 Canales BK, Li Y, Thompson MG, Gleason JM, Chen Z, Malaeb B, Corey DR, Herbert BS, Shay JW, Koeneman KS. Small molecule, oligonucleotide-based telomerase template inhibition in combination with cytolytic therapy in an in vitro androgen-independent prostate cancer model. Urologic Oncology. 24: 141-51. PMID 16520278 DOI: 10.1016/j.urolonc.2005.11.003  1
2006 Sato M, Vaughan MB, Girard L, Peyton M, Lee W, Shames DS, Ramirez RD, Sunaga N, Gazdar AF, Shay JW, Minna JD. Multiple oncogenic changes (K-RASV12, p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells Cancer Research. 66: 2116-2128. PMID 16489012 DOI: 10.1158/0008-5472.CAN-05-2521  1
2006 Chai W, Du Q, Shay JW, Wright WE. Human telomeres have different overhang sizes at leading versus lagging strands. Molecular Cell. 21: 427-35. PMID 16455497 DOI: 10.1016/j.molcel.2005.12.004  1
2006 Moshnikova A, Frye J, Shay JW, Minna JD, Khokhlatchev AV. The growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathway Journal of Biological Chemistry. 281: 8143-8152. PMID 16421102 DOI: 10.1074/jbc.M511837200  1
2006 Chai W, Sfeir AJ, Hoshiyama H, Shay JW, Wright WE. The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres. Embo Reports. 7: 225-30. PMID 16374507 DOI: 10.1038/sj.embor.7400600  1
2006 Gellert GC, Dikmen ZG, Wright WE, Gryaznov S, Shay JW. Effects of a novel telomerase inhibitor, GRN163L, in human breast cancer. Breast Cancer Research and Treatment. 96: 73-81. PMID 16319992 DOI: 10.1007/s10549-005-9043-5  1
2005 Shay JW, Wright WE. Use of telomerase to create bioengineered tissues. Annals of the New York Academy of Sciences. 1057: 479-91. PMID 16399914 DOI: 10.1196/annals.1356.037  1
2005 Fujimoto N, Wislez M, Zhang J, Iwanaga K, Dackor J, Hanna AE, Kalyankrishna S, Cody DD, Price RE, Sato M, Shay JW, Minna JD, Peyton M, Tang X, Massarelli E, et al. High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor. Cancer Research. 65: 11478-85. PMID 16357156 DOI: 10.1158/0008-5472.CAN-05-1977  1
2005 Alonso MM, Fueyo J, Shay JW, Aldape KD, Jiang H, Lee OH, Johnson DG, Xu J, Kondo Y, Kanzawa T, Kyo S, Bekele BN, Zhou X, Nigro J, McDonald JM, et al. Expression of transcription factor E2F1 and telomerase in glioblastomas: mechanistic linkage and prognostic significance. Journal of the National Cancer Institute. 97: 1589-600. PMID 16264179 DOI: 10.1093/jnci/dji340  1
2005 Sfeir AJ, Shay JW, Wright WE. Fine-tuning the chromosome ends: the last base of human telomeres. Cell Cycle (Georgetown, Tex.). 4: 1467-70. PMID 16258279  1
2005 Sashida G, Ohyashiki JH, Kubota N, Shoji N, Ishii Y, Tauchi T, Kimura Y, Shay JW, Ohyashiki K. Marked telomere fluctuation of leukocytes during graft-versus-host disease in allogeneic stem cell transplantation. International Journal of Molecular Medicine. 16: 883-8. PMID 16211259  1
2005 Dikmen ZG, Gellert GC, Jackson S, Gryaznov S, Tressler R, Dogan P, Wright WE, Shay JW. In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor. Cancer Research. 65: 7866-73. PMID 16140956 DOI: 10.1158/0008-5472.CAN-05-1215  1
2005 Takakura M, Kyo S, Inoue M, Wright WE, Shay JW. Function of AP-1 in transcription of the telomerase reverse transcriptase gene (TERT) in human and mouse cells. Molecular and Cellular Biology. 25: 8037-43. PMID 16135795 DOI: 10.1128/MCB.25.18.8037-8043.2005  1
2005 Wright WE, Shay JW. Telomere biology in aging and cancer. Journal of the American Geriatrics Society. 53: S292-4. PMID 16131355 DOI: 10.1111/j.1532-5415.2005.53492.x  1
2005 Michaloglou C, Vredeveld LCW, Soengas MS, Denoyelle C, Kuilman T, Van Der Horst CMAM, Majoor DM, Shay JW, Mooi WJ, Peeper DS. BRAFE600-associated senescence-like cell cycle arrest of human naevi Nature. 436: 720-724. PMID 16079850 DOI: 10.1038/nature03890  1
2005 Hockemeyer D, Sfeir AJ, Shay JW, Wright WE, de Lange T. POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. The Embo Journal. 24: 2667-78. PMID 15973431 DOI: 10.1038/sj.emboj.7600733  1
2005 Heuzé-Vourc'h N, Liu M, Dalwadi H, Baratelli FE, Zhu L, Goodglick L, Põld M, Sharma S, Ramirez RD, Shay JW, Minna JD, Strieter RM, Dubinett SM. IL-20, an anti-angiogenic cytokine that inhibits COX-2 expression Biochemical and Biophysical Research Communications. 333: 470-475. PMID 15950941 DOI: 10.1016/j.bbrc.2005.05.122  1
2005 Herbert BS, Gellert GC, Hochreiter A, Pongracz K, Wright WE, Zielinska D, Chin AC, Harley CB, Shay JW, Gryaznov SM. Lipid modification of GRN163, an N3'-->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition. Oncogene. 24: 5262-8. PMID 15940257 DOI: 10.1038/sj.onc.1208760  1
2005 Ohyashiki K, Shay JW, Ohyashiki JH. Lack of mutations of the human telomerase RNA gene (hTERC) in myelodysplastic syndrome Haematologica. 90: 691. PMID 15921388  1
2005 Forsyth NR, Elder FF, Shay JW, Wright WE. Lagomorphs (rabbits, pikas and hares) do not use telomere-directed replicative aging in vitro. Mechanisms of Ageing and Development. 126: 685-91. PMID 15888323 DOI: 10.1016/j.mad.2005.01.003  1
2005 Shay JW. Meeting report: The role of telomeres and telomerase in cancer Cancer Research. 65: 3513-3517. PMID 15867339 DOI: 10.1158/0008-5472.CAN-05-0728  1
2005 Sfeir AJ, Chai W, Shay JW, Wright WE. Telomere-end processing the terminal nucleotides of human chromosomes. Molecular Cell. 18: 131-8. PMID 15808515 DOI: 10.1016/j.molcel.2005.02.035  1
2005 Chai W, Shay JW, Wright WE. Human telomeres maintain their overhang length at senescence. Molecular and Cellular Biology. 25: 2158-68. PMID 15743814 DOI: 10.1128/MCB.25.6.2158-2168.2005  1
2005 Wright WE, Shay JW. Telomere-binding factors and general DNA repair. Nature Genetics. 37: 116-8. PMID 15678140 DOI: 10.1038/ng0205-116  1
2005 Robertson DM, Li L, Fisher S, Pearce VP, Shay JW, Wright WE, Cavanagh HD, Jester JV. Characterization of growth and differentiation in a telomerase-immortalized human corneal epithelial cell line. Investigative Ophthalmology & Visual Science. 46: 470-8. PMID 15671271 DOI: 10.1167/iovs.04-0528  1
2005 Shay JW, Wright WE. Mechanism-based combination telomerase inhibition therapy. Cancer Cell. 7: 1-2. PMID 15652743 DOI: 10.1016/j.ccr.2004.12.012  1
2005 Shay JW, Wright WE. Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis. 26: 867-74. PMID 15471900 DOI: 10.1093/carcin/bgh296  1
2005 Gellert GC, Jackson SR, Dikmen ZG, Wright WE, Shay JW. Telomerase as a therapeutic target in cancer Drug Discovery Today: Disease Mechanisms. 2: 159-164. DOI: 10.1016/j.ddmec.2005.05.009  1
2005 Sfeir AJ, Shay JW, Wright WE. Fine-tuning the chromosome ends: The last base of human telomeres Cell Cycle. 4: 1465-1468.  1
2005 Dikmen ZG, Gellert G, Doǧan P, Mason R, Antich P, Richer E, Wright WE, Shay JW. A new diagnostic system in cancer research: Bioluminescent imaging (BLI) Turkish Journal of Medical Sciences. 35: 65-70.  1
2005 Shay JW, Wright WE. Does telomerase moonlight? Scientist. 19: 18-19.  1
2004 Ramirez RD, Sheridan S, Girard L, Sato M, Kim Y, Pollack J, Peyton M, Zou Y, Kurie JM, Dimaio JM, Milchgrub S, Smith AL, Souza RF, Gilbey L, Zhang X, ... ... Shay JW, et al. Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Research. 64: 9027-34. PMID 15604268 DOI: 10.1158/0008-5472.CAN-04-3703  1
2004 Zou Y, Gryaznov SM, Shay JW, Wright WE, Cornforth MN. Asynchronous replication timing of telomeres at opposite arms of mammalian chromosomes. Proceedings of the National Academy of Sciences of the United States of America. 101: 12928-33. PMID 15322275 DOI: 10.1073/pnas.0404106101  1
2004 Vaughan MB, Ramirez RD, Brown SA, Yang JC, Wright WE, Shay JW. A reproducible laser-wounded skin equivalent model to study the effects of aging in vitro. Rejuvenation Research. 7: 99-110. PMID 15312297 DOI: 10.1089/1549168041552982  1
2004 Baur JA, Wright WE, Shay JW. Analysis of mammalian telomere position effect. Methods in Molecular Biology (Clifton, N.J.). 287: 121-36. PMID 15273408 DOI: 10.1385/1-59259-828-5:121  1
2004 Sunaga N, Miyajima K, Suzuki M, Sato M, White MA, Ramirez RD, Shay JW, Gazdar AF, Minna JD. Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer Cancer Research. 64: 4277-4285. PMID 15205342 DOI: 10.1158/0008-5472.CAN-03-3941  1
2004 Troester MA, Hoadley KA, Sørlie T, Herbert BS, Børresen-Dale AL, Lønning PE, Shay JW, Kaufmann WK, Perou CM. Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Research. 64: 4218-26. PMID 15205334 DOI: 10.1158/0008-5472.CAN-04-0107  1
2004 Nishi H, Nakada T, Kyo S, Inoue M, Shay JW, Isaka K. Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT) Molecular and Cellular Biology. 24: 6076-6083. PMID 15199161 DOI: 10.1128/MCB.24.13.6076-6083.2004  1
2004 Zhang H, Herbert BS, Pan KH, Shay JW, Cohen SN. Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions. Oncogene. 23: 6193-8. PMID 15195144 DOI: 10.1038/sj.onc.1207834  1
2004 Zou Y, Sfeir A, Gryaznov SM, Shay JW, Wright WE. Does a sentinel or a subset of short telomeres determine replicative senescence? Molecular Biology of the Cell. 15: 3709-18. PMID 15181152 DOI: 10.1091/mbc.E04-03-0207  1
2004 Forsyth NR, Morales CP, Damle S, Boman B, Wright WE, Kopelovich L, Shay JW. Spontaneous immortalization of clinically normal colon-derived fibroblasts from a familial adenomatous polyposis patient. Neoplasia (New York, N.Y.). 6: 258-65. PMID 15153338 DOI: 10.1593/neo.4103  1
2004 Bechter OE, Zou Y, Walker W, Wright WE, Shay JW. Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition. Cancer Research. 64: 3444-51. PMID 15150096 DOI: 10.1158/0008-5472.CAN-04-0323  1
2004 Shay JW, Wright WE. Telomeres are double-strand DNA breaks hidden from DNA damage responses. Molecular Cell. 14: 420-1. PMID 15149591 DOI: 10.1016/S1097-2765(04)00269-2  1
2004 Steinert S, Shay JW, Wright WE. Modification of subtelomeric DNA. Molecular and Cellular Biology. 24: 4571-80. PMID 15121873 DOI: 10.1128/MCB.24.10.4571-4580.2004  1
2004 Shay JW, Wright WE. Telomeres in dyskeratosis congenita. Nature Genetics. 36: 437-8. PMID 15118675 DOI: 10.1038/ng0504-437  1
2004 Shay JW, Roninson IB. Hallmarks of senescence in carcinogenesis and cancer therapy Oncogene. 23: 2919-2933. PMID 15077154 DOI: 10.1038/sj.onc.1207518  1
2004 Bechter OE, Shay JW, Wright WE. The frequency of homologous recombination in human ALT cells. Cell Cycle (Georgetown, Tex.). 3: 547-9. PMID 15034305  1
2004 Walter M, Forsyth NR, Wright WE, Shay JW, Roth MG. The establishment of telomerase-immortalized Tangier disease cell lines indicates the existence of an apolipoprotein A-I-inducible but ABCA1-independent cholesterol efflux pathway. The Journal of Biological Chemistry. 279: 20866-73. PMID 15001567 DOI: 10.1074/jbc.M401714200  1
2004 Baur JA, Shay JW, Wright WE. Spontaneous reactivation of a silent telomeric transgene in a human cell line. Chromosoma. 112: 240-6. PMID 14735368 DOI: 10.1007/s00412-003-0269-x  1
2004 Tsyganov EN, Antich PP, Kulkarni PV, Mason RP, Parkey RW, Seliuonine SY, Shay JW, Soesbe TW, Zinchenko AI. Micro-SPECT combined with 3-D optical imaging Ieee Nuclear Science Symposium Conference Record. 5: 3275-3279.  1
2003 Herbert BS, Shay JW, Wright WE. Analysis of telomeres and telomerase. Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [Et Al.]. Unit 18.6. PMID 18228424 DOI: 10.1002/0471143030.cb1806s20  1
2003 Hiyama E, Hiyama K, Nishiyama M, Partrik Reynolds C, Shay JW, Yokoyama T. Differential Gene Expression Profiles between Neuroblastomas with High Telomerase Activity and Low Telomerase Activity Journal of Pediatric Surgery. 38: 1730-1734. PMID 14666454 DOI: 10.1016/j.jpedsurg.2003.08.042  1
2003 Bechter OE, Zou Y, Shay JW, Wright WE. Homologous recombination in human telomerase-positive and ALT cells occurs with the same frequency. Embo Reports. 4: 1138-43. PMID 14618159 DOI: 10.1038/sj.embor.7400027  1
2003 Velicescu M, Yu J, Herbert BS, Shay JW, Granada E, Dubeau L. Aneuploidy and telomere attrition are independent determinants of crisis in SV40-transformed epithelial cells Cancer Research. 63: 5813-5820. PMID 14522904  1
2003 Shay JW. Telomerase therapeutics: Telomeres recognized as a DNA damage signal Clinical Cancer Research. 9: 3521-3525. PMID 14506137  1
2003 Wu X, Amos CI, Zhu Y, Zhao H, Grossman BH, Shay JW, Luo S, Hong WK, Spitz MR. Telomere dysfunction: A potential cancer predisposition factor Journal of the National Cancer Institute. 95: 1211-1218. PMID 12928346  1
2003 Jester JV, Huang J, Fisher S, Spiekerman J, Chang JH, Wright WE, Shay JW. Myofibroblast differentiation of normal human keratocytes and hTERT, extended-life human corneal fibroblasts. Investigative Ophthalmology & Visual Science. 44: 1850-8. PMID 12714615 DOI: 10.1167/iovs.02-0973  1
2003 Herbert BS, Pearce VP, Hynan LS, LaRue DM, Wright WE, Kopelovich L, Shay JW. A peroxisome proliferator-activated receptor-gamma agonist and the p53 rescue drug CP-31398 inhibit the spontaneous immortalization of breast epithelial cells. Cancer Research. 63: 1914-9. PMID 12702583  1
2003 Sengupta S, Linke SP, Pedeux R, Yang Q, Farnsworth J, Garfield SH, Valerie K, Shay JW, Ellis NA, Wasylyk B, Harris CC. BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination. The Embo Journal. 22: 1210-22. PMID 12606585 DOI: 10.1093/emboj/cdg114  1
2003 Zhang X, Multani AS, Zhou JH, Shay JW, McConkey D, Dong L, Kim CS, Rosser CJ, Pathak S, Benedict WF. Adenoviral-mediated retinoblastoma 94 produces rapid telomere erosion, chromosomal crisis, and caspase-dependent apoptosis in bladder cancer and immortalized human urothelial cells but not in normal urothelial cells Cancer Research. 63: 760-765. PMID 12591722  1
2003 Morales CP, Gandia KG, Ramirez RD, Wright WE, Shay JW, Spechler SJ. Characterisation of telomerase immortalised normal human oesophageal squamous cells Gut. 52: 327-333. PMID 12584211 DOI: 10.1136/gut.52.3.327  1
2003 Ramirez RD, Herbert BS, Vaughan MB, Zou Y, Gandia K, Morales CP, Wright WE, Shay JW. Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells Oncogene. 22: 433-444. PMID 12545164 DOI: 10.1038/sj.onc.1206046  1
2000 Ouellette MM, Liao M, Herbert BS, Johnson M, Holt SE, Liss HS, Shay JW, Wright WE. Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase. The Journal of Biological Chemistry. 275: 10072-6. PMID 10744686 DOI: 10.1074/jbc.275.14.10072  1
1999 Tesmer VM, Ford LP, Holt SE, Frank BC, Yi X, Aisner DL, Ouellette M, Shay JW, Wright WE. Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro. Molecular and Cellular Biology. 19: 6207-16. PMID 10454567  1
1999 Holt SE, Shay JW. Role of telomerase in cellular proliferation and cancer. Journal of Cellular Physiology. 180: 10-8. PMID 10362013 DOI: 10.1002/(SICI)1097-4652(199907)180:1<10::AID-JCP2>3.0.CO;2-D  1
1999 Holt SE, Aisner DL, Baur J, Tesmer VM, Dy M, Ouellette M, Trager JB, Morin GB, Toft DO, Shay JW, Wright WE, White MA. Functional requirement of p23 and Hsp90 in telomerase complexes. Genes & Development. 13: 817-26. PMID 10197982  1
1999 Morales CP, Holt SE, Ouellette M, Kaur KJ, Yan Y, Wilson KS, White MA, Wright WE, Shay JW. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nature Genetics. 21: 115-8. PMID 9916803 DOI: 10.1038/5063  1
1998 Norton JC, Holt SE, Wright WE, Shay JW. Enhanced detection of human telomerase activity. Dna and Cell Biology. 17: 217-9. PMID 9539101  1
1998 Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S, Wright WE. Extension of life-span by introduction of telomerase into normal human cells. Science (New York, N.Y.). 279: 349-52. PMID 9454332 DOI: 10.1126/science.279.5349.349  1
1997 Weinrich SL, Pruzan R, Ma L, Ouellette M, Tesmer VM, Holt SE, Bodnar AG, Lichtsteiner S, Kim NW, Trager JB, Taylor RD, Carlos R, Andrews WH, Wright WE, Shay JW, et al. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nature Genetics. 17: 498-502. PMID 9398860 DOI: 10.1038/ng1297-498  1
1997 Holt SE, Aisner DL, Shay JW, Wright WE. Lack of cell cycle regulation of telomerase activity in human cells. Proceedings of the National Academy of Sciences of the United States of America. 94: 10687-92. PMID 9380696 DOI: 10.1073/pnas.94.20.10687  1
1997 Holt SE, Wright WE, Shay JW. Multiple pathways for the regulation of telomerase activity. European Journal of Cancer (Oxford, England : 1990). 33: 761-6. PMID 9282114 DOI: 10.1016/S0959-8049(97)00066-X  1
1996 Holt SE, Shay JW, Wright WE. Refining the telomere-telomerase hypothesis of aging and cancer. Nature Biotechnology. 14: 836-9. PMID 9631006 DOI: 10.1038/nbt0796-836  1
1996 Holt SE, Wright WE, Shay JW. Regulation of telomerase activity in immortal cell lines. Molecular and Cellular Biology. 16: 2932-9. PMID 8649404  1
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