| Year |
Citation |
Score |
| 2020 |
Lin L, Lemieux GA, Enogieru OJ, Giacomini KM, Ashrafi K. Neural production of kynurenic acid in requires the AAT-1 transporter. Genes & Development. PMID 32675325 DOI: 10.1101/Gad.339119.120 |
0.312 |
|
| 2020 |
Chen WW, Lemieux GA, Camp CH, Chang TC, Ashrafi K, Cicerone MT. Spectroscopic coherent Raman imaging of Caenorhabditis elegans reveals lipid particle diversity. Nature Chemical Biology. PMID 32572275 DOI: 10.1038/S41589-020-0565-2 |
0.366 |
|
| 2019 |
Bouagnon AD, Lin L, Srivastava S, Liu CC, Panda O, Schroeder FC, Srinivasan S, Ashrafi K. Intestinal peroxisomal fatty acid β-oxidation regulates neural serotonin signaling through a feedback mechanism. Plos Biology. 17: e3000242. PMID 31805041 DOI: 10.1371/Journal.Pbio.3000242 |
0.407 |
|
| 2019 |
Butler VJ, Gao F, Corrales CI, Cortopassi WA, Caballero B, Vohra M, Ashrafi K, Cuervo AM, Jacobson MP, Coppola G, Kao AW. Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response. Plos Genetics. 15: e1008295. PMID 31398187 DOI: 10.1371/Journal.Pgen.1008295 |
0.411 |
|
| 2018 |
Chisnell P, Parenteau TR, Tank E, Ashrafi K, Kenyon C. The mTOR Target S6 Kinase Arrests Development in When Heat-Shock Transcription Factor Is Impaired. Genetics. PMID 30228197 DOI: 10.1534/Genetics.118.301533 |
0.319 |
|
| 2017 |
Vohra M, Lemieux GA, Lin L, Ashrafi K. The beneficial effects of dietary restriction on learning are distinct from its effects on longevity and mediated by depletion of a neuroinhibitory metabolite. Plos Biology. 15: e2002032. PMID 28763436 DOI: 10.1371/Journal.Pbio.2002032 |
0.303 |
|
| 2016 |
Lemieux GA, Ashrafi K. Investigating Connections between Metabolism, Longevity, and Behavior in Caenorhabditis elegans. Trends in Endocrinology and Metabolism: Tem. PMID 27289335 DOI: 10.1016/J.Tem.2016.05.004 |
0.453 |
|
| 2015 |
Yee LE, Garcia-Gonzalo FR, Bowie RV, Li C, Kennedy JK, Ashrafi K, Blacque OE, Leroux MR, Reiter JF. Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling. Plos Genetics. 11: e1005627. PMID 26540106 DOI: 10.1371/Journal.Pgen.1005627 |
0.336 |
|
| 2015 |
Lemieux GA, Ashrafi K. Neural Regulatory Pathways of Feeding and Fat in Caenorhabditis elegans. Annual Review of Genetics. PMID 26473379 DOI: 10.1146/Annurev-Genet-120213-092244 |
0.464 |
|
| 2015 |
Lemieux GA, Ashrafi K. Stressing about misplaced fat is a key to longevity. Elife. 4. PMID 26287524 DOI: 10.7554/Elife.10161 |
0.34 |
|
| 2015 |
Lemieux GA, Cunningham KA, Lin L, Mayer F, Werb Z, Ashrafi K. Kynurenic acid is a nutritional cue that enables behavioral plasticity. Cell. 160: 119-31. PMID 25594177 DOI: 10.1016/J.Cell.2014.12.028 |
0.405 |
|
| 2015 |
Lemieux GA, Ashrafi K. Insights and challenges in using C. elegans for investigation of fat metabolism. Critical Reviews in Biochemistry and Molecular Biology. 50: 69-84. PMID 25228063 DOI: 10.3109/10409238.2014.959890 |
0.489 |
|
| 2014 |
Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, ... ... Ashrafi K, et al. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proceedings of the National Academy of Sciences of the United States of America. 111: 9983-8. PMID 24961373 DOI: 10.1073/Pnas.1314939111 |
0.338 |
|
| 2014 |
Cunningham KA, Bouagnon AD, Barros AG, Lin L, Malard L, Romano-Silva MA, Ashrafi K. Loss of a neural AMP-activated kinase mimics the effects of elevated serotonin on fat, movement, and hormonal secretions. Plos Genetics. 10: e1004394. PMID 24921650 DOI: 10.1371/Journal.Pgen.1004394 |
0.444 |
|
| 2014 |
Ward JD, Mullaney B, Schiller BJ, He le D, Petnic SE, Couillault C, Pujol N, Bernal TU, Van Gilst MR, Ashrafi K, Ewbank JJ, Yamamoto KR. Defects in the C. elegans acyl-CoA synthase, acs-3, and nuclear hormone receptor, nhr-25, cause sensitivity to distinct, but overlapping stresses. Plos One. 9: e92552. PMID 24651852 DOI: 10.1371/Journal.Pone.0092552 |
0.715 |
|
| 2014 |
Barros AG, Bridi JC, de Souza BR, de Castro Júnior C, de Lima Torres KC, Malard L, Jorio A, de Miranda DM, Ashrafi K, Romano-Silva MA. Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans. Plos One. 9: e85874. PMID 24465759 DOI: 10.1371/Journal.Pone.0085874 |
0.329 |
|
| 2014 |
Min J, Attia RN, Arnold LA, Teske K, Connelly M, Lemieux G, Ashrafi K, Shelat A, Guy RK. Abstract 5389: Discovery of small molecule inhibitors of the interaction between PPARγ and SMRT Cancer Research. 74: 5389-5389. DOI: 10.1158/1538-7445.Am2014-5389 |
0.333 |
|
| 2013 |
Ward JD, Bojanala N, Bernal T, Ashrafi K, Asahina M, Yamamoto KR. Sumoylated NHR-25/NR5A regulates cell fate during C. elegans vulval development. Plos Genetics. 9: e1003992. PMID 24348269 DOI: 10.1371/Journal.Pgen.1003992 |
0.388 |
|
| 2013 |
Lemieux GA, Keiser MJ, Sassano MF, Laggner C, Mayer F, Bainton RJ, Werb Z, Roth BL, Shoichet BK, Ashrafi K. In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding. Plos Biology. 11: e1001712. PMID 24260022 DOI: 10.1371/Journal.Pbio.1001712 |
0.36 |
|
| 2013 |
Chen AT, Guo C, Dumas KJ, Ashrafi K, Hu PJ. Effects of Caenorhabditis elegans sgk-1 mutations on lifespan, stress resistance, and DAF-16/FoxO regulation. Aging Cell. 12: 932-40. PMID 23786484 DOI: 10.1111/acel.12120 |
0.357 |
|
| 2012 |
Cunningham KA, Hua Z, Srinivasan S, Liu J, Lee BH, Edwards RH, Ashrafi K. AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans. Cell Metabolism. 16: 113-21. PMID 22768843 DOI: 10.1016/J.Cmet.2012.05.014 |
0.402 |
|
| 2012 |
Barros AG, Liu J, Lemieux GA, Mullaney BC, Ashrafi K. Analyses of C. elegans fat metabolic pathways. Methods in Cell Biology. 107: 383-407. PMID 22226531 DOI: 10.1016/B978-0-12-394620-1.00013-8 |
0.747 |
|
| 2011 |
Lee BH, Liu J, Wong D, Srinivasan S, Ashrafi K. Hyperactive neuroendocrine secretion causes size, feeding, and metabolic defects of C. elegans Bardet-Biedl syndrome mutants. Plos Biology. 9: e1001219. PMID 22180729 DOI: 10.1371/Journal.Pbio.1001219 |
0.426 |
|
| 2011 |
Lemieux GA, Liu J, Mayer N, Bainton RJ, Ashrafi K, Werb Z. A whole-organism screen identifies new regulators of fat storage. Nature Chemical Biology. 7: 206-13. PMID 21390037 DOI: 10.1038/Nchembio.534 |
0.434 |
|
| 2010 |
Mullaney BC, Blind RD, Lemieux GA, Perez CL, Elle IC, Faergeman NJ, Van Gilst MR, Ingraham HA, Ashrafi K. Regulation of C. elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25. Cell Metabolism. 12: 398-410. PMID 20889131 DOI: 10.1016/J.Cmet.2010.08.013 |
0.75 |
|
| 2009 |
Jones KT, Ashrafi K. Caenorhabditis elegans as an emerging model for studying the basic biology of obesity. Disease Models & Mechanisms. 2: 224-9. PMID 19407330 DOI: 10.1242/dmm.001933 |
0.44 |
|
| 2009 |
Jones KT, Greer ER, Pearce D, Ashrafi K. Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1. Plos Biology. 7: e60. PMID 19260765 DOI: 10.1371/Journal.Pbio.1000060 |
0.649 |
|
| 2009 |
Cunningham KA, Ashrafi K. Fat rationing in dauer times. Cell Metabolism. 9: 113-4. PMID 19187769 DOI: 10.1016/J.Cmet.2009.01.008 |
0.32 |
|
| 2009 |
Mullaney BC, Ashrafi K. C. elegans fat storage and metabolic regulation. Biochimica Et Biophysica Acta. 1791: 474-8. PMID 19168149 DOI: 10.1016/J.Bbalip.2008.12.013 |
0.75 |
|
| 2008 |
Lee BH, Ashrafi K. A TRPV channel modulates C. elegans neurosecretion, larval starvation survival, and adult lifespan. Plos Genetics. 4: e1000213. PMID 18846209 DOI: 10.1371/journal.pgen.1000213 |
0.34 |
|
| 2008 |
Greer ER, Pérez CL, Van Gilst MR, Lee BH, Ashrafi K. Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding. Cell Metabolism. 8: 118-31. PMID 18680713 DOI: 10.1016/j.cmet.2008.06.005 |
0.647 |
|
| 2008 |
Srinivasan S, Sadegh L, Elle IC, Christensen AG, Faergeman NJ, Ashrafi K. Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms. Cell Metabolism. 7: 533-44. PMID 18522834 DOI: 10.1016/J.Cmet.2008.04.012 |
0.473 |
|
| 2007 |
Ashrafi K. Obesity and the regulation of fat metabolism. Wormbook : the Online Review of C. Elegans Biology. 1-20. PMID 18050496 DOI: 10.1895/wormbook.1.130.1 |
0.491 |
|
| 2007 |
Husson SJ, Janssen T, Baggerman G, Bogert B, Kahn-Kirby AH, Ashrafi K, Schoofs L. Impaired processing of FLP and NLP peptides in carboxypeptidase E (EGL-21)-deficient Caenorhabditis elegans as analyzed by mass spectrometry. Journal of Neurochemistry. 102: 246-60. PMID 17564681 DOI: 10.1111/J.1471-4159.2007.04474.X |
0.711 |
|
| 2006 |
Ashrafi K. Mapping out starvation responses. Cell Metabolism. 3: 235-6. PMID 16581000 DOI: 10.1016/j.cmet.2006.03.002 |
0.335 |
|
| 2003 |
Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, Ruvkun G. Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature. 421: 268-72. PMID 12529643 DOI: 10.1038/Nature01279 |
0.597 |
|
| 2001 |
Bhatnagar RS, Ashrafi K, Fütterer K, Waksman G, Gordon JI. 9 Biology and enzymology of protein N-myristoylation Enzymes. 21: 241-290. DOI: 10.1016/S1874-6047(01)80022-6 |
0.611 |
|
| 1999 |
Ashrafi K, Sinclair D, Gordon JI, Guarente L. Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 96: 9100-5. PMID 10430902 DOI: 10.1073/Pnas.96.16.9100 |
0.374 |
|
| 1998 |
Ashrafi K, Farazi TA, Gordon JI. A role for Saccharomyces cerevisiae fatty acid activation protein 4 in regulating protein N-myristoylation during entry into stationary phase. The Journal of Biological Chemistry. 273: 25864-74. PMID 9748261 DOI: 10.1074/Jbc.273.40.25864 |
0.686 |
|
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