| Year |
Citation |
Score |
| 2016 |
Monaghan M, Wakabayashi H, Griffiths AE, Fay PJ. Stabilizing Interactions between D666-S1787 and T657-Y1792 at the A2-A3 Interface Support Factor VIIIa Stability in the Blood Clotting Pathway. Journal of Thrombosis and Haemostasis : Jth. PMID 26878264 DOI: 10.1111/Jth.13292 |
0.419 |
|
| 2015 |
Leong L, Sim D, Patel C, Tran K, Liu P, Ho E, Thompson T, Kretschmer PJ, Wakabayashi H, Fay PJ, Murphy JE. Noncovalent stabilization of the factor VIII A2 domain enhances efficacy in hemophilia A mouse vascular injury models. Blood. 125: 392-8. PMID 25331117 DOI: 10.1182/Blood-2014-02-555656 |
0.444 |
|
| 2014 |
Kosloski MP, Shetty KA, Wakabayashi H, Fay PJ, Balu-Iyer SV. Effects of replacement of factor VIII amino acids Asp519 and Glu665 with Val on plasma survival and efficacy in vivo. The Aaps Journal. 16: 1038-45. PMID 24934295 DOI: 10.1208/S12248-014-9627-2 |
0.455 |
|
| 2014 |
Monaghan M, Wakabayashi H, Griffiths A, Wintermute J, Fay PJ. Enhanced factor VIIIa stability of A2 domain interface variants results from an increased apparent affinity for the A2 subunit. Results from an increased apparent affinity for the A2 subunit. Thrombosis and Haemostasis. 112: 495-502. PMID 24899227 DOI: 10.1160/Th14-01-0086 |
0.467 |
|
| 2014 |
Wakabayashi H, Monaghan M, Fay PJ. Cofactor activity in factor VIIIa of the blood clotting pathway is stabilized by an interdomain bond between His281 and Ser524 formed in factor VIII. The Journal of Biological Chemistry. 289: 14020-9. PMID 24692542 DOI: 10.1074/Jbc.M114.550566 |
0.482 |
|
| 2014 |
Wakabayashi H, Wintermute JM, Fay PJ. Combining mutations that modulate inter-subunit interactions and proteolytic inactivation enhance the stability of factor VIIIa. Thrombosis and Haemostasis. 112: 43-52. PMID 24599523 DOI: 10.1160/Th13-10-0918 |
0.414 |
|
| 2013 |
Griffiths AE, Wintermute J, Newell-Caito JL, Fay PJ. Residues flanking scissile bonds in Factor VIII modulate rates of cleavage and proteolytic activation catalyzed by Factor Xa. Biochemistry. 52: 8060-8. PMID 24128092 DOI: 10.1021/Bi4010123 |
0.496 |
|
| 2013 |
Wakabayashi H, Fay PJ. Replacing the factor VIII C1 domain with a second C2 domain reduces factor VIII stability and affinity for factor IXa. The Journal of Biological Chemistry. 288: 31289-97. PMID 24030831 DOI: 10.1074/Jbc.M113.497289 |
0.448 |
|
| 2013 |
Wakabayashi H, Fay PJ. Modification of interdomain interfaces within the A3C1C2 subunit of factor VIII affects its stability and activity. Biochemistry. 52: 3921-9. PMID 23659383 DOI: 10.1021/Bi400295X |
0.479 |
|
| 2013 |
Griffiths AE, Rydkin I, Fay PJ. Factor VIIIa A2 subunit shows a high affinity interaction with factor IXa: contribution of A2 subunit residues 707-714 to the interaction with factor IXa. The Journal of Biological Chemistry. 288: 15057-64. PMID 23580639 DOI: 10.1074/Jbc.M113.456467 |
0.496 |
|
| 2013 |
Wakabayashi H, Fay PJ. Molecular orientation of factor VIIIa on the phospholipid membrane surface determined by fluorescence resonance energy transfer. The Biochemical Journal. 452: 293-301. PMID 23521092 DOI: 10.1042/Bj20130025 |
0.409 |
|
| 2013 |
Takeyama M, Wintermute JM, Manithody C, Rezaie AR, Fay PJ. Variable contributions of basic residues forming an APC exosite in the binding and inactivation of factor VIIIa. Biochemistry. 52: 2228-35. PMID 23480827 DOI: 10.1021/Bi301632G |
0.475 |
|
| 2013 |
Yada K, Nogami K, Wakabayashi H, Fay PJ, Shima M. The mild phenotype in severe hemophilia A with Arg1781His mutation is associated with enhanced binding affinity of factor VIII for factor X Thrombosis and Haemostasis. 109: 1007-1015. PMID 23467620 DOI: 10.1160/Th12-10-0762 |
0.367 |
|
| 2013 |
Takeyama M, Wakabayashi H, Fay PJ. Contribution of factor VIII light-chain residues 2007-2016 to an activated protein C-interactive site. Thrombosis and Haemostasis. 109: 187-98. PMID 23224054 DOI: 10.1160/Th12-08-0561 |
0.491 |
|
| 2013 |
Wakabayashi H, Wintermute J, Fay PJ. Stabilizing Factor VIIIa By Combining Mutations That Modulate Inter-Subunit Interactions and Proteolytic Inactivation Blood. 122: 3572-3572. DOI: 10.1182/Blood.V122.21.3572.3572 |
0.441 |
|
| 2013 |
Yada K, Nogami K, Takeyama M, Minami H, Fay PJ, Shima M. Reduced Affinity To VWF Induced By a Novel Mutation At Pro1809Leu (factor VIII-Tenri) Is The Cause Of Mild Hemophilia A Developing Anti-Factor VIII Inhibitor Blood. 122: 2343-2343. DOI: 10.1182/Blood.V122.21.2343.2343 |
0.43 |
|
| 2012 |
Newell-Caito JL, Griffiths AE, Fay PJ. P3-P3' residues flanking scissile bonds in factor VIII modulate rates of substrate cleavage and procofactor activation by thrombin. Biochemistry. 51: 3451-9. PMID 22455313 DOI: 10.1021/Bi300070Z |
0.489 |
|
| 2012 |
DeAngelis JP, Wakabayashi H, Fay PJ. Sequences flanking Arg336 in factor VIIIa modulate factor Xa-catalyzed cleavage rates at this site and cofactor function. The Journal of Biological Chemistry. 287: 15409-17. PMID 22411993 DOI: 10.1074/Jbc.M111.333948 |
0.75 |
|
| 2012 |
Takeyama M, Wakabayashi H, Fay PJ. Factor VIII light chain contains a binding site for factor X that contributes to the catalytic efficiency of factor Xase. Biochemistry. 51: 820-8. PMID 22224589 DOI: 10.1021/Bi201731P |
0.439 |
|
| 2012 |
Wakabayashi H, Griffiths AE, Fay PJ. Enhancing factor VIII and VIIIa stability by combining mutations at the A2 domain interface and A1-C2 domain interface. Journal of Thrombosis and Haemostasis : Jth. 10: 492-5. PMID 22187981 DOI: 10.1111/J.1538-7836.2011.04597.X |
0.476 |
|
| 2012 |
Yada K, Nogami K, Ogiwara K, Wakabayashi H, Fay PJ, Shima M. A Coagulation Mechanism for the Mild Bleeding Tendency in a Patient with Severe Hemophilia A Possessing an Arg1781His Mutation. Blood. 120: 2213-2213. DOI: 10.1182/Blood.V120.21.2213.2213 |
0.341 |
|
| 2011 |
Wakabayashi H, Griffiths AE, Fay PJ. Increasing hydrophobicity or disulfide bridging at the factor VIII A1 and C2 domain interface enhances procofactor stability. The Journal of Biological Chemistry. 286: 25748-55. PMID 21628455 DOI: 10.1074/Jbc.M111.241109 |
0.479 |
|
| 2011 |
DeAngelis JP, Varfaj F, Wakabayashi H, Fay PJ. The role of P4-P3' residues flanking Arg336 in facilitating activated protein C-catalyzed cleavage and inactivation of factor VIIIa. Thrombosis Research. 128: 470-6. PMID 21470668 DOI: 10.1016/J.Thromres.2011.03.007 |
0.824 |
|
| 2011 |
Novakovic VA, Cullinan DB, Wakabayashi H, Fay PJ, Baleja JD, Gilbert GE. Membrane-binding properties of the Factor VIII C2 domain. The Biochemical Journal. 435: 187-96. PMID 21210768 DOI: 10.1042/Bj20101797 |
0.376 |
|
| 2011 |
Messer AS, Ulmasov B, Kumar Y, Vadivel K, Zhong D, Fay P, Bajaj SP. Epitope Mapping of a Monoclonal Antibody to Factor VIII That Inhibits Factor IXa:Factor VIIIa Interaction and Thrombin Activation of Factor VIII Blood. 118: 1177-1177. DOI: 10.1182/Blood.V118.21.1177.1177 |
0.476 |
|
| 2010 |
Wakabayashi H, Griffiths AE, Fay PJ. Factor VIII lacking the C2 domain retains cofactor activity in vitro. The Journal of Biological Chemistry. 285: 25176-84. PMID 20529839 DOI: 10.1074/Jbc.M110.106906 |
0.377 |
|
| 2009 |
Jagannathan I, Ichikawa HT, Kruger T, Fay PJ. Identification of residues in the 558-loop of factor VIIIa A2 subunit that interact with factor IXa. The Journal of Biological Chemistry. 284: 32248-55. PMID 19801661 DOI: 10.1074/Jbc.M109.050781 |
0.47 |
|
| 2009 |
Newell JL, Fay PJ. Cleavage at Arg-1689 influences heavy chain cleavages during thrombin-catalyzed activation of factor VIII. The Journal of Biological Chemistry. 284: 11080-9. PMID 19240027 DOI: 10.1074/Jbc.M900234200 |
0.776 |
|
| 2009 |
Wakabayashi H, Griffiths AE, Fay PJ. Combining mutations of charged residues at the A2 domain interface enhances factor VIII stability over single point mutations. Journal of Thrombosis and Haemostasis : Jth. 7: 438-44. PMID 19067791 DOI: 10.1111/J.1538-7836.2008.03256.X |
0.387 |
|
| 2009 |
Newell JL, Griffiths AE, Fay PJ. Residues Surrounding Arg372, Arg740, and Arg1689 Contribute to the Rates of Thrombin-Catalyzed Cleavage of Factor VIII. Blood. 114: 847-847. DOI: 10.1182/Blood.V114.22.847.847 |
0.715 |
|
| 2009 |
Wakabayashi H, Griffiths AE, Fay P. Increasing Hydrophobicity and Disulfide Bridging Between A1 and C2 Subunits Improves Factor VIII Stability. Blood. 114: 3176-3176. DOI: 10.1182/Blood.V114.22.3176.3176 |
0.482 |
|
| 2009 |
Wang W, Griffiths AE, Fay P. Epitope Mapping of a Human Inhibitor Plasma by Affinity-Directed Mass Spectrometry. Blood. 114: 3171-3171. DOI: 10.1182/Blood.V114.22.3171.3171 |
0.447 |
|
| 2008 |
Wakabayashi H, Varfaj F, Deangelis J, Fay PJ. Generation of enhanced stability factor VIII variants by replacement of charged residues at the A2 domain interface. Blood. 112: 2761-9. PMID 18650448 DOI: 10.1182/Blood-2008-02-142158 |
0.816 |
|
| 2008 |
Newell JL, Fay PJ. Acidic residues C-terminal to the A2 domain facilitate thrombin-catalyzed activation of factor VIII. Biochemistry. 47: 8786-95. PMID 18642885 DOI: 10.1021/Bi8007824 |
0.765 |
|
| 2008 |
Wakabayashi H, Fay PJ. Identification of residues contributing to A2 domain-dependent structural stability in factor VIII and factor VIIIa. The Journal of Biological Chemistry. 283: 11645-51. PMID 18299331 DOI: 10.1074/Jbc.M710252200 |
0.496 |
|
| 2008 |
Newell JL, Fay P. Thrombin Cleavage at Arg1689 Influences Subsequent Cleavage at Arg372 during Activation of Factor VIII Blood. 112: 1021-1021. DOI: 10.1182/Blood.V112.11.1021.1021 |
0.768 |
|
| 2008 |
Wakabayashi H, Griffiths AE, Fay P. Enhancement of Factor VIII Stability by Replacing Multiple Charged Residues at the A2 Domain Interface Blood. 112: 1016-1016. DOI: 10.1182/Blood.V112.11.1016.1016 |
0.481 |
|
| 2007 |
Newell JL, Fay PJ. Proteolysis at Arg740 facilitates subsequent bond cleavages during thrombin-catalyzed activation of factor VIII. The Journal of Biological Chemistry. 282: 25367-75. PMID 17595160 DOI: 10.1074/Jbc.M703433200 |
0.78 |
|
| 2007 |
Varfaj F, Wakabayashi H, Fay PJ. Residues surrounding Arg336 and Arg562 contribute to the disparate rates of proteolysis of factor VIIIa catalyzed by activated protein C. The Journal of Biological Chemistry. 282: 20264-72. PMID 17519239 DOI: 10.1074/Jbc.M701327200 |
0.784 |
|
| 2007 |
Wakabayashi H, Zhou Q, Varfaj F, Fay PJ. A3 domain residue Glu1829 contributes to A2 subunit retention in factor VIIIa. Journal of Thrombosis and Haemostasis : Jth. 5: 996-1001. PMID 17371488 DOI: 10.1182/Blood.V108.11.1690.1690 |
0.802 |
|
| 2007 |
Varfaj F, Wakabayashi H, Fay PJ. The Mutation Leu335Pro in Factor VIII Results in Its Rapid Inactivation by Thrombin-Catalyzed Proteolysis at Arg336. Blood. 110: 2690-2690. DOI: 10.1182/Blood.V110.11.2690.2690 |
0.835 |
|
| 2007 |
Varfaj F, DeAngelis J, Wakabayashi H, Fay PJ. P2 and P2′ Residues Are Important for the Efficient Proteolysis of Factor VIIIa at Arg336 Catalyzed by Activated Protein C. Blood. 110: 2689-2689. DOI: 10.1182/Blood.V110.11.2689.2689 |
0.825 |
|
| 2007 |
Ichikawa HT, Chadha S, Zhou Q, Fay PJ. Contributions of Residues in the 558-Loop of Factor VIIIa A2 Subunit to Interactions with Factor IXa in Factor Xase. Blood. 110: 2688-2688. DOI: 10.1182/Blood.V110.11.2688.2688 |
0.451 |
|
| 2007 |
Newell J, Zhou Q, Fay PJ. Thrombin-Catalyzed Cleavages of Factor VIII at Arg372 and Arg1689 Are Facilitated by the Acidic Residues Glu720-Asp725. Blood. 110: 2686-2686. DOI: 10.1182/Blood.V110.11.2686.2686 |
0.78 |
|
| 2007 |
Wakabayashi H, Fay PJ. Localization of Factor VIII Residues Contributing to Factor VIII and/or VIIIa Structural Stability as Detected by Rates of Activity Decay. Blood. 110: 1763-1763. DOI: 10.1182/Blood.V110.11.1763.1763 |
0.516 |
|
| 2007 |
Varfaj F, Wakabayashi H, Fay P. LEU335 CONTRIBUTES TO THE EFFICIENT PROTEOLYSIS OF FACTOR VIIIA AT ARG336 CATALYZED BY ACTIVATED PROTEIN C Journal of Thrombosis and Haemostasis. 5: P-S-038-P-S-038. DOI: 10.1111/J.1538-7836.2007.Tb00137.X |
0.778 |
|
| 2006 |
Ansong C, Miles SM, Fay PJ. Factor VIII A1 domain residues 97-105 represent a light chain-interactive site. Biochemistry. 45: 13140-9. PMID 17073436 DOI: 10.1021/Bi061202W |
0.731 |
|
| 2006 |
Wakabayashi H, Zhou Q, Nogami K, Ansong C, Varfaj F, Miles S, Fay PJ. pH-dependent association of factor VIII chains: enhancement of affinity at physiological pH by Cu2+. Biochimica Et Biophysica Acta. 1764: 1094-101. PMID 16731058 DOI: 10.1182/Blood.V106.11.1015.1015 |
0.76 |
|
| 2006 |
Ansong C, Miles SM, Fay PJ. Epitope mapping factor VIII A2 domain by affinity-directed mass spectrometry: residues 497-510 and 584-593 comprise a discontinuous epitope for the monoclonal antibody R8B12. Journal of Thrombosis and Haemostasis : Jth. 4: 842-7. PMID 16634755 DOI: 10.1111/J.1538-7836.2006.01831.X |
0.696 |
|
| 2006 |
Varfaj F, Neuberg J, Jenkins PV, Wakabayashi H, Fay PJ. Role of P1 residues Arg336 and Arg562 in the activated-Protein-C-catalysed inactivation of Factor VIIIa. The Biochemical Journal. 396: 355-62. PMID 16503879 DOI: 10.1042/Bj20060117 |
0.833 |
|
| 2006 |
Ichikawa HT, Zhou Q, Fay PJ. A Cluster of Basic Residues in the Factor VIIIa A2 Subunit Function in Substrate Binding and Product Release during the Activation of Factor X by Factor Xase. Blood. 108: 196-196. DOI: 10.1182/Blood.V108.11.196.196 |
0.521 |
|
| 2006 |
Varfaj F, Wakabayashi H, Fay PJ. Contribution of P4-P3′ Residues Surrounding P1 Residues Arg336 and Arg562 in the Activated Protein C-Catalyzed Inactivation of Factor VIIIa. Blood. 108: 1693-1693. DOI: 10.1182/Blood.V108.11.1693.1693 |
0.839 |
|
| 2006 |
Newell J, Fay PJ. Cleavage at Arg740 Appears Essential for Thrombin-Catalyzed Cleavage at Arg372 during the Activation of Factor VIII. Blood. 108: 1692-1692. DOI: 10.1182/Blood.V108.11.1692.1692 |
0.753 |
|
| 2005 |
Wakabayashi H, Su YC, Ahmad SS, Walsh PN, Fay PJ. A Glu113Ala mutation within a factor VIII Ca2+-binding site enhances cofactor interactions in factor Xase. Biochemistry. 44: 10298-304. PMID 16042406 DOI: 10.1021/Bi050638T |
0.471 |
|
| 2005 |
Ansong C, Fay PJ. Factor VIII A3 domain residues 1954-1961 represent an A1 domain-interactive site. Biochemistry. 44: 8850-7. PMID 15952791 DOI: 10.1021/Bi050145O |
0.725 |
|
| 2005 |
Nogami K, Zhou Q, Myles T, Leung LL, Wakabayashi H, Fay PJ. Exosite-interactive regions in the A1 and A2 domains of factor VIII facilitate thrombin-catalyzed cleavage of heavy chain. The Journal of Biological Chemistry. 280: 18476-87. PMID 15746105 DOI: 10.1074/Jbc.M412778200 |
0.514 |
|
| 2005 |
Nogami K, Zhou Q, Wakabayashi H, Fay PJ. Thrombin-catalyzed activation of factor VIII with His substituted for Arg372 at the P1 site. Blood. 105: 4362-8. PMID 15705787 DOI: 10.1182/Blood-2004-10-3939 |
0.494 |
|
| 2005 |
Fay PJ, Jenkins PV. Mutating factor VIII: lessons from structure to function. Blood Reviews. 19: 15-27. PMID 15572214 DOI: 10.1016/J.Blre.2004.02.003 |
0.389 |
|
| 2005 |
FAY PJ. Factor VIII structure and the regulation of cofactor activity Japanese Journal of Thrombosis and Hemostasis. 16: 24-38. DOI: 10.2491/Jjsth.16.24 |
0.325 |
|
| 2005 |
Ansong C, Miles S, Fay PJ. Factor VIII A2 Domain Residues 497–510 and 584–593 Comprise the R8B12 Epitope. Blood. 106: 4028-4028. DOI: 10.1182/Blood.V106.11.4028.4028 |
0.692 |
|
| 2005 |
Miles SM, Freas J, Fay PJ. Mapping Factor VIIIa Inter-Subunit Interactions Using Chemical Modification and Zero-Length Cross-Linking. Blood. 106: 1016-1016. DOI: 10.1182/Blood.V106.11.1016.1016 |
0.446 |
|
| 2004 |
Nogami K, Wakabayashi H, Ansong C, Fay PJ. Localization of a pH-dependent, A2 subunit-interactive surface within the factor VIIIa A1 subunit. Biochimica Et Biophysica Acta. 1701: 25-35. PMID 15450173 DOI: 10.1016/J.Bbapap.2004.06.002 |
0.689 |
|
| 2004 |
Nogami K, Freas J, Manithody C, Wakabayashi H, Rezaie AR, Fay PJ. Mechanisms of interactions of factor X and factor Xa with the acidic region in the factor VIII A1 domain. The Journal of Biological Chemistry. 279: 33104-13. PMID 15166225 DOI: 10.1074/Jbc.M405537200 |
0.491 |
|
| 2004 |
Jenkins PV, Dill JL, Zhou Q, Fay PJ. Contribution of factor VIIIa A2 and A3-C1-C2 subunits to the affinity for factor IXa in factor Xase. Biochemistry. 43: 5094-101. PMID 15109268 DOI: 10.1021/Bi036289P |
0.456 |
|
| 2004 |
Jenkins PV, Dill JL, Zhou Q, Fay PJ. Clustered basic residues within segment 484-510 of the factor VIIIa A2 subunit contribute to the catalytic efficiency for factor Xa generation. Journal of Thrombosis and Haemostasis : Jth. 2: 452-8. PMID 15009463 DOI: 10.1111/J.1538-7933.2004.00625.X |
0.484 |
|
| 2004 |
Nogami K, Lapan KA, Zhou Q, Wakabayashi H, Fay PJ. Identification of a factor Xa-interactive site within residues 337-372 of the factor VIII heavy chain. The Journal of Biological Chemistry. 279: 15763-71. PMID 14764590 DOI: 10.1074/Jbc.M400568200 |
0.523 |
|
| 2004 |
Wakabayashi H, Freas J, Zhou Q, Fay PJ. Residues 110-126 in the A1 domain of factor VIII contain a Ca2+ binding site required for cofactor activity. The Journal of Biological Chemistry. 279: 12677-84. PMID 14722121 DOI: 10.1074/Jbc.M311042200 |
0.401 |
|
| 2004 |
Fay PJ. Activation of factor VIII and mechanisms of cofactor action. Blood Reviews. 18: 1-15. PMID 14684146 DOI: 10.1016/S0268-960X(03)00025-0 |
0.411 |
|
| 2004 |
Peng H, Sahni A, Fay P, Bellum S, Prudovsky I, Maciag T, Francis CW. Identification of a binding site on human FGF-2 for fibrinogen. Blood. 103: 2114-20. PMID 14630795 DOI: 10.1182/Blood-2003-08-2638 |
0.318 |
|
| 2004 |
Varfaj F, Neuberg J, Wakabayashi H, Fay PJ. Exosite Interactions Contribute to the Activated Protein C-Catalyzed Inactivation of Factor VIIIa. Blood. 104: 1739-1739. DOI: 10.1182/Blood.V104.11.1739.1739 |
0.821 |
|
| 2004 |
Wakabayashi H, Zhou Q, Nogami K, Fay PJ. Effects of Single Point Mutations within Proposed Copper Binding Sites on Specific Activity and Inter-Chain Affinity of Factor VIII. Blood. 104: 1730-1730. DOI: 10.1182/Blood.V104.11.1730.1730 |
0.414 |
|
| 2004 |
Wakabayashi H, Fay PJ. Factor VIII:E113A Represents a High Specific Activity Factor VIII Arising from a Single Point Mutation within a Ca 2+ Binding Site. Blood. 104: 1725-1725. DOI: 10.1182/Blood.V104.11.1725.1725 |
0.445 |
|
| 2004 |
Nogami K, Zhou Q, Wakabayashi H, Myles T, Leung LL, Fay PJ. Mechanism of Interaction between the Heavy Chain of Factor VIII and Thrombin. Blood. 104: 1711-1711. DOI: 10.1182/Blood.V104.11.1711.1711 |
0.501 |
|
| 2003 |
Balakrishnan M, Roques BP, Fay PJ, Bambara RA. Template dimerization promotes an acceptor invasion-induced transfer mechanism during human immunodeficiency virus type 1 minus-strand synthesis. Journal of Virology. 77: 4710-21. PMID 12663778 DOI: 10.1128/Jvi.77.8.4710-4721.2003 |
0.606 |
|
| 2003 |
Nogami K, Wakabayashi H, Fay PJ. Mechanisms of factor Xa-catalyzed cleavage of the factor VIIIa A1 subunit resulting in cofactor inactivation. The Journal of Biological Chemistry. 278: 16502-9. PMID 12606556 DOI: 10.1074/Jbc.M213044200 |
0.488 |
|
| 2003 |
Manithody C, Fay PJ, Rezaie AR. Exosite-dependent regulation of factor VIIIa by activated protein C. Blood. 101: 4802-7. PMID 12595311 DOI: 10.1182/Blood-2003-01-0126 |
0.525 |
|
| 2003 |
Wakabayashi H, Zhen Z, Schmidt KM, Fay PJ. Mn2+ binding to factor VIII subunits and its effect on cofactor activity. Biochemistry. 42: 145-53. PMID 12515549 DOI: 10.1021/Bi026430E |
0.367 |
|
| 2003 |
Chen Y, Balakrishnan M, Roques BP, Fay PJ, Bambara RA. Mechanism of minus strand strong stop transfer in HIV-1 reverse transcription. The Journal of Biological Chemistry. 278: 8006-17. PMID 12499370 DOI: 10.1074/Jbc.M210959200 |
0.591 |
|
| 2003 |
Nogami K, Wakabayashi H, Schmidt K, Fay PJ. Altered interactions between the A1 and A2 subunits of factor VIIIa following cleavage of A1 subunit by factor Xa. The Journal of Biological Chemistry. 278: 1634-41. PMID 12426309 DOI: 10.1074/Jbc.M209811200 |
0.449 |
|
| 2002 |
Roda RH, Balakrishnan M, Kim JK, Roques BP, Fay PJ, Bambara RA. Strand transfer occurs in retroviruses by a pause-initiated two-step mechanism. The Journal of Biological Chemistry. 277: 46900-11. PMID 12370183 DOI: 10.1074/Jbc.M208638200 |
0.609 |
|
| 2002 |
Jenkins PV, Freas J, Schmidt KM, Zhou Q, Fay PJ. Mutations associated with hemophilia A in the 558-565 loop of the factor VIIIa A2 subunit alter the catalytic activity of the factor Xase complex. Blood. 100: 501-8. PMID 12091341 DOI: 10.1182/Blood-2001-12-0361 |
0.471 |
|
| 2002 |
Wisniewski M, Chen Y, Balakrishnan M, Palaniappan C, Roques BP, Fay PJ, Bambara RA. Substrate requirements for secondary cleavage by HIV-1 reverse transcriptase RNase H. The Journal of Biological Chemistry. 277: 28400-10. PMID 12023278 DOI: 10.1074/Jbc.M201645200 |
0.788 |
|
| 2002 |
Koszelak Rosenblum ME, Schmidt K, Freas J, Mastri M, Fay PJ. Cofactor activities of factor VIIIa and A2 subunit following cleavage of A1 subunit at Arg336. The Journal of Biological Chemistry. 277: 11664-9. PMID 11799130 DOI: 10.1074/Jbc.M200037200 |
0.464 |
|
| 2001 |
Wakabayashi H, Koszelak ME, Mastri M, Fay PJ. Metal ion-independent association of factor VIII subunits and the roles of calcium and copper ions for cofactor activity and inter-subunit affinity. Biochemistry. 40: 10293-300. PMID 11513607 DOI: 10.1021/Bi010353Q |
0.337 |
|
| 2001 |
Fay PJ, Mastri M, Koszelak ME. Factor VIIIa cofactor activity shows enhanced ionic strength sensitivity in the absence of phospholipid. Biochimica Et Biophysica Acta. 1548: 159-68. PMID 11451449 DOI: 10.1016/S0167-4838(01)00225-4 |
0.47 |
|
| 2001 |
Balakrishnan M, Fay PJ, Bambara RA. The kissing hairpin sequence promotes recombination within the HIV-I 5' leader region. The Journal of Biological Chemistry. 276: 36482-92. PMID 11432862 DOI: 10.1074/Jbc.M102860200 |
0.624 |
|
| 2001 |
Bajaj SP, Schmidt AE, Mathur A, Padmanabhan K, Zhong D, Mastri M, Fay PJ. Factor IXa:factor VIIIa interaction. helix 330-338 of factor ixa interacts with residues 558-565 and spatially adjacent regions of the a2 subunit of factor VIIIa. The Journal of Biological Chemistry. 276: 16302-9. PMID 11278963 DOI: 10.1074/jbc.M011680200 |
0.413 |
|
| 2001 |
Fay PJ, Mastri M, Koszelak ME, Wakabayashi H. Cleavage of factor VIII heavy chain is required for the functional interaction of a2 subunit with factor IXA. The Journal of Biological Chemistry. 276: 12434-9. PMID 11278520 DOI: 10.1074/Jbc.M009539200 |
0.491 |
|
| 2000 |
Wisniewski M, Balakrishnan M, Palaniappan C, Fay PJ, Bambara RA. Unique progressive cleavage mechanism of HIV reverse transcriptase RNase H. Proceedings of the National Academy of Sciences of the United States of America. 97: 11978-83. PMID 11035788 DOI: 10.1073/Pnas.210392297 |
0.79 |
|
| 2000 |
Wisniewski M, Balakrishnan M, Palaniappan C, Fay PJ, Bambara RA. The sequential mechanism of HIV reverse transcriptase RNase H. The Journal of Biological Chemistry. 275: 37664-71. PMID 10956669 DOI: 10.1074/Jbc.M007381200 |
0.792 |
|
| 2000 |
Archer RH, Dykes C, Gerondelis P, Lloyd A, Fay P, Reichman RC, Bambara RA, Demeter LM. Mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture. Journal of Virology. 74: 8390-401. PMID 10954539 DOI: 10.1128/Jvi.74.18.8390-8401.2000 |
0.622 |
|
| 2000 |
Koszelak ME, Huggins CF, Fay PJ. Sites in the A2 subunit involved in the interfactor VIIIa interaction. The Journal of Biological Chemistry. 275: 27137-44. PMID 10831590 DOI: 10.1074/Jbc.M002478200 |
0.432 |
|
| 2000 |
O'Brien LM, Mastri M, Fay PJ. Regulation of factor VIIIa by human activated protein C and protein S: inactivation of cofactor in the intrinsic factor Xase Blood. 95: 1714-1720. DOI: 10.1182/blood.V95.5.1714.005k40_1714_1720 |
0.411 |
|
| 1999 |
Fay PJ, Scandella D. Human inhibitor antibodies specific for the factor VIII A2 domain disrupt the interaction between the subunit and factor IXa. The Journal of Biological Chemistry. 274: 29826-30. PMID 10514461 DOI: 10.1074/Jbc.274.42.29826 |
0.485 |
|
| 1999 |
Wisniewski M, Palaniappan C, Fu Z, Le Grice SF, Fay P, Bambara RA. Mutations in the primer grip region of HIV reverse transcriptase can increase replication fidelity. The Journal of Biological Chemistry. 274: 28175-84. PMID 10497170 DOI: 10.1074/Jbc.274.40.28175 |
0.761 |
|
| 1999 |
Gerondelis P, Archer RH, Palaniappan C, Reichman RC, Fay PJ, Bambara RA, Demeter LM. The P236L delavirdine-resistant human immunodeficiency virus type 1 mutant is replication defective and demonstrates alterations in both RNA 5'-end- and DNA 3'-end-directed RNase H activities. Journal of Virology. 73: 5803-13. PMID 10364332 DOI: 10.1128/Jvi.73.7.5803-5813.1999 |
0.626 |
|
| 1999 |
Fay PJ, Koshibu K, Mastri M. The A1 and A2 subunits of factor VIIIa synergistically stimulate factor IXa catalytic activity. The Journal of Biological Chemistry. 274: 15401-6. PMID 10336428 DOI: 10.1074/Jbc.274.22.15401 |
0.465 |
|
| 1999 |
Fay P. Regulation of Factor VIIIa in the Intrinsic Factor Xase Thrombosis and Haemostasis. 82: 193-200. DOI: 10.1055/S-0037-1615833 |
0.388 |
|
| 1998 |
Fay PJ, Koshibu K. The A2 subunit of factor VIIIa modulates the active site of factor IXa. The Journal of Biological Chemistry. 273: 19049-54. PMID 9668086 DOI: 10.1074/Jbc.273.30.19049 |
0.491 |
|
| 1998 |
Pieneman WC, Fay P, Briët E, Reitsma PH, Bertina RM. Partial reconstitution of factor VIII activity from a mild Crm+ hemophilia A patient by replacement of the defective A2 domain Thrombosis and Haemostasis. 79: 943-948. PMID 9609226 DOI: 10.1055/s-0037-1615099 |
0.401 |
|
| 1998 |
Sudhakar K, Fay PJ. Effects of copper on the structure and function of factor VIII subunits: evidence for an auxiliary role for copper ions in cofactor activity. Biochemistry. 37: 6874-82. PMID 9578574 DOI: 10.1021/Bi980084C |
0.337 |
|
| 1998 |
Palaniappan C, Kim JK, Wisniewski M, Fay PJ, Bambara RA. Control of initiation of viral plus strand DNA synthesis by HIV reverse transcriptase. The Journal of Biological Chemistry. 273: 3808-16. PMID 9461561 DOI: 10.1074/Jbc.273.7.3808 |
0.786 |
|
| 1998 |
Lapan K, Fay P. Interaction of the A1 Subunit of Factor VIIIa and the Serine Protease Domain of Factor X Identified by Zero-length Cross-linking Thrombosis and Haemostasis. 80: 418-422. DOI: 10.1055/S-0037-1615223 |
0.475 |
|
| 1997 |
Kim JK, Palaniappan C, Wu W, Fay PJ, Bambara RA. Evidence for a unique mechanism of strand transfer from the transactivation response region of HIV-1. The Journal of Biological Chemistry. 272: 16769-77. PMID 9201981 DOI: 10.1074/Jbc.272.27.16769 |
0.591 |
|
| 1997 |
Lu Y, Planelles V, Li X, Palaniappan C, Day B, Challita-Eid P, Amado R, Stephens D, Kohn DB, Bakker A, Fay P, Bambara RA, Rosenblatt JD. Inhibition of HIV-1 replication using a mutated tRNALys-3 primer. The Journal of Biological Chemistry. 272: 14523-31. PMID 9169409 DOI: 10.1074/Jbc.272.23.14523 |
0.591 |
|
| 1997 |
Palaniappan C, Wisniewski M, Jacques PS, Le Grice SF, Fay PJ, Bambara RA. Mutations within the primer grip region of HIV-1 reverse transcriptase result in loss of RNase H function. The Journal of Biological Chemistry. 272: 11157-64. PMID 9111014 DOI: 10.1074/Jbc.272.17.11157 |
0.797 |
|
| 1997 |
Lapan KA, Fay PJ. Localization of a factor X interactive site in the A1 subunit of factor VIIIa. The Journal of Biological Chemistry. 272: 2082-8. PMID 8999906 DOI: 10.1074/Jbc.272.4.2082 |
0.492 |
|
| 1997 |
O'Brien LM, Huggins CF, Fay PJ. Interacting Regions in the A1 and A2 Subunits of Factor VIIIa Identified by Zero-Length Cross-Linking Blood. 90: 3943-3950. DOI: 10.1182/Blood.V90.10.3943 |
0.454 |
|
| 1996 |
Fuentes GM, Palaniappan C, Fay PJ, Bambara RA. Strand displacement synthesis in the central polypurine tract region of HIV-1 promotes DNA to DNA strand transfer recombination. The Journal of Biological Chemistry. 271: 29605-11. PMID 8939890 DOI: 10.1074/Jbc.271.47.29605 |
0.599 |
|
| 1996 |
Sudhakar K, Fay PJ. Exposed hydrophobic sites in factor VIII and isolated subunits. The Journal of Biological Chemistry. 271: 23015-21. PMID 8798489 DOI: 10.1074/Jbc.271.38.23015 |
0.479 |
|
| 1996 |
Palaniappan C, Wisniewski M, Wu W, Fay PJ, Bambara RA. Misincorporation by HIV-1 reverse transcriptase promotes recombination via strand transfer synthesis. The Journal of Biological Chemistry. 271: 22331-8. PMID 8798393 DOI: 10.1074/Jbc.271.37.22331 |
0.793 |
|
| 1996 |
Fuentes GM, Fay PJ, Bambara RA. Relationship between plus strand DNA synthesis removal of downstream segments of RNA by human immunodeficiency virus, murine leukemia virus and avian myeloblastoma virus reverse transcriptases. Nucleic Acids Research. 24: 1719-26. PMID 8649991 DOI: 10.1093/Nar/24.9.1719 |
0.602 |
|
| 1996 |
Wu W, Palaniappan C, Bambara RA, Fay PJ. Differences in mutagenesis during minus strand, plus strand and strand transfer (recombination) synthesis of the HIV-1 gene in vitro. Nucleic Acids Research. 24: 1710-8. PMID 8649990 DOI: 10.1093/Nar/24.9.1710 |
0.601 |
|
| 1996 |
Regan LM, O'Brien LM, Beattie TL, Sudhakar K, Walker FJ, Fay PJ. Activated protein C-catalyzed proteolysis of factor VIIIa alters its interactions within factor Xase. The Journal of Biological Chemistry. 271: 3982-7. PMID 8626729 DOI: 10.1074/Jbc.271.8.3982 |
0.503 |
|
| 1996 |
Fay PJ, Beattie TL, Regan LM, O'Brien LM, Kaufman RJ. Model for the factor VIIIa-dependent decay of the intrinsic factor Xase. Role of subunit dissociation and factor IXa-catalyzed proteolysis. The Journal of Biological Chemistry. 271: 6027-32. PMID 8626386 DOI: 10.1074/Jbc.271.11.6027 |
0.5 |
|
| 1996 |
Fuentes GM, Rodríguez-Rodríguez L, Palaniappan C, Fay PJ, Bambara RA. Strand displacement synthesis of the long terminal repeats by HIV reverse transcriptase. The Journal of Biological Chemistry. 271: 1966-71. PMID 8567645 DOI: 10.1074/Jbc.271.4.1966 |
0.606 |
|
| 1996 |
Palaniappan C, Fuentes GM, Rodríguez-Rodríguez L, Fay PJ, Bambara RA. Helix Structure and Ends of RNA/DNA Hybrids Direct the Cleavage Specificity of HIV-1 Reverse Transcriptase RNase H Journal of Biological Chemistry. 271: 2063-2070. DOI: 10.1074/Jbc.271.4.2063 |
0.602 |
|
| 1995 |
Bambara RA, Fay PJ, Mallaber LM. Methods of analyzing processivity. Methods in Enzymology. 262: 270-80. PMID 8594353 DOI: 10.1016/0076-6879(95)62023-0 |
0.572 |
|
| 1995 |
Regan LM, Fay PJ. Cleavage of factor VIII light chain is required for maximal generation of factor VIIIa activity Journal of Biological Chemistry. 270: 8546-8552. PMID 7721754 DOI: 10.1074/Jbc.270.15.8546 |
0.487 |
|
| 1995 |
O'Brien LM, Medved LV, Fay PJ. Localization of factor IXa and factor VIIIa interactive sites Journal of Biological Chemistry. 270: 27087-27092. PMID 7592960 DOI: 10.1074/Jbc.270.45.27087 |
0.501 |
|
| 1995 |
Rodríguez-Rodríguez L, Tsuchihashi Z, Fuentes GM, Bambara RA, Fay PJ. Influence of human immunodeficiency virus nucleocapsid protein on synthesis and strand transfer by the reverse transcriptase in vitro. The Journal of Biological Chemistry. 270: 15005-11. PMID 7541033 DOI: 10.1074/Jbc.270.25.15005 |
0.587 |
|
| 1995 |
Palaniappan C, Fay PJ, Bambara RA. Nevirapine alters the cleavage specificity of ribonuclease H of human immunodeficiency virus 1 reverse transcriptase. The Journal of Biological Chemistry. 270: 4861-9. PMID 7533167 DOI: 10.1074/Jbc.270.9.4861 |
0.628 |
|
| 1995 |
Wu W, Blumberg BM, Fay PJ, Bambara RA. Strand transfer mediated by human immunodeficiency virus reverse transcriptase in vitro is promoted by pausing and results in misincorporation. The Journal of Biological Chemistry. 270: 325-32. PMID 7529228 DOI: 10.1074/Jbc.270.1.325 |
0.609 |
|
| 1995 |
Fuentes GM, Rodríguez-Rodríguez L, Fay PJ, Bambara RA. Use of an oligoribonucleotide containing the polypurine tract sequence as a primer by HIV reverse transcriptase. The Journal of Biological Chemistry. 270: 28169-76. PMID 7499308 DOI: 10.1074/Jbc.270.47.28169 |
0.618 |
|
| 1994 |
Destefano JJ, Mallaber LM, Fay PJ, Bambara RA. Quantitative analysis of RNA cleavage during rnadirected DNA synthesis by human immunodeficiency and avian myeloblastosis virus reverse transcriptases Nucleic Acids Research. 22: 3793-3800. PMID 7524028 DOI: 10.1093/Nar/22.18.3793 |
0.609 |
|
| 1994 |
DeStefano JJ, Wu W, Seehra J, McCoy J, Laston D, Albone E, Fay PJ, Bambara RA. Characterization of an RNase H deficient mutant of human immunodeficiency virus-1 reverse transcriptase having an aspartate to asparagine change at position 498 Bba - Gene Structure and Expression. 1219: 380-388. PMID 7522572 DOI: 10.1016/0167-4781(94)90062-0 |
0.603 |
|
| 1993 |
Buiser RG, Bambara RA, Fay PJ. Pausing by retroviral DNA polymerases promotes strand transfer from internal regions of RNA donor templates to homopolymeric acceptor templates. Biochimica Et Biophysica Acta. 1216: 20-30. PMID 7692974 DOI: 10.1016/0167-4781(93)90033-A |
0.621 |
|
| 1993 |
Destefano JJ, Mallaber LM, Fay PJ, Bambara RA. Determinants of the RNAse H cleavage specificity of human immunodeficiency virus reverse transcriptase Nucleic Acids Research. 21: 4330-4338. PMID 7692401 DOI: 10.1093/Nar/21.18.4330 |
0.613 |
|
| 1993 |
DeStefano JJ, Bambara RA, Fay PJ. Parameters that influence the binding of human immunodeficiency virus reverse transcriptase to nucleic acid structures Biochemistry. 32: 6908-6915. PMID 7687463 DOI: 10.1021/Bi00078A014 |
0.599 |
|
| 1992 |
Destefano JJ, Mallaber LM, Rodriguez-Rodriguez L, Fay PJ, Bambara RA. Requirements for strand transfer between internal regions of heteropolymer templates by human immunodeficiency virus reverse transcriptase Journal of Virology. 66: 6370-6378. PMID 1383563 DOI: 10.1128/Jvi.66.11.6370-6378.1992 |
0.619 |
|
| 1992 |
DeStefano JJ, Buiser RG, Mallaber LM, Fay PJ, Bambara RA. Parameters that influence processive synthesis and site-specific termination by human immunodeficiency virus reverse transcriptase on RNA and DNA templates Bba - Gene Structure and Expression. 1131: 270-280. PMID 1378301 DOI: 10.1016/0167-4781(92)90025-U |
0.623 |
|
| 1992 |
Walker FJ, Fay PJ. Regulation of blood coagulation by the protein C system. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 6: 2561-7. PMID 1317308 DOI: 10.1096/Fasebj.6.8.1317308 |
0.349 |
|
| 1992 |
Lamphear B, Fay P. Proteolytic interactions of factor IXa with human factor VIII and factor VIIIa Blood. 80: 3120-3126. DOI: 10.1182/Blood.V80.12.3120.Bloodjournal80123120 |
0.481 |
|
| 1992 |
Lamphear B, Fay P. Proteolytic interactions of factor IXa with human factor VIII and factor VIIIa Blood. 80: 3120-3126. DOI: 10.1182/blood.v80.12.3120.3120 |
0.38 |
|
| 1990 |
Fowler WE, Fay PJ, Arvan DS, Marder VJ. Electron microscopy of human factor V and factor VIII: correlation of morphology with domain structure and localization of factor V activation fragments. Proceedings of the National Academy of Sciences of the United States of America. 87: 7648-52. PMID 2120705 DOI: 10.1073/Pnas.87.19.7648 |
0.424 |
|
| 1989 |
Fay PJ, Walker FJ. Inactivation of human factor VIII by activated protein C: evidence that the factor VIII light chain contains the activated protein C binding site. Biochimica Et Biophysica Acta. 994: 142-8. PMID 2521291 DOI: 10.1016/0167-4838(89)90153-2 |
0.393 |
|
| 1988 |
Fay PJ. Reconstitution of human factor VIII from isolated subunits. Archives of Biochemistry and Biophysics. 262: 525-31. PMID 3129993 DOI: 10.1016/0003-9861(88)90404-3 |
0.363 |
|
| 1988 |
Fay PJ. Subunit structure of thrombin-activated human factor VIIIa. Biochimica Et Biophysica Acta. 952: 181-90. PMID 3122836 DOI: 10.1016/0167-4838(88)90114-8 |
0.411 |
|
| 1987 |
Wagner DD, Fay PJ, Sporn LA, Sinha S, Lawrence SO, Marder VJ. Divergent fates of von Willebrand factor and its propolypeptide (von Willebrand antigen II) after secretion from endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. 84: 1955-9. PMID 3494248 DOI: 10.1073/Pnas.84.7.1955 |
0.302 |
|
| 1987 |
Walker FJ, Chavin SI, Fay PJ. Inactivation of factor VIII by activated protein C and protein S. Archives of Biochemistry and Biophysics. 252: 322-8. PMID 2949697 DOI: 10.1016/0003-9861(87)90037-3 |
0.411 |
|
| 1987 |
Wagner D, Lawrence S, Ohlsson-Wilhelm B, Fay P, Marder V. Topology and order of formation of interchain disulfide bonds in von Willebrand factor Blood. 69: 27-32. DOI: 10.1182/Blood.V69.1.27.27 |
0.327 |
|
| 1986 |
Fay PJ, Kawai Y, Wagner DD, Ginsburg D, Bonthron D, Ohlsson-Wilhelm BM, Chavin SI, Abraham GN, Handin RI, Orkin SH. Propolypeptide of von Willebrand factor circulates in blood and is identical to von Willebrand antigen II. Science (New York, N.Y.). 232: 995-8. PMID 3486471 DOI: 10.1126/Science.3486471 |
0.312 |
|
| 1986 |
Fay PJ, Anderson MT, Chavin SI, Marder VJ. The size of human factor VIII heterodimers and the effects produced by thrombin. Biochimica Et Biophysica Acta. 871: 268-78. PMID 3085715 DOI: 10.1016/0167-4838(86)90208-6 |
0.332 |
|
| 1986 |
Fay PJ, Cavallaro C, Marder VJ, Pancham N, Fournel MA, Schroeder DD. Comparison of the in vivo survival of human factor VIII with and without von Willebrand factor in the hemophilic dog. Thrombosis Research. 41: 425-9. PMID 3085273 DOI: 10.1016/0049-3848(86)90253-7 |
0.309 |
|
| 1986 |
Fay PJ, Chavin SI, Meyer D, Marder VJ. Chapter 2B Nonenzymatic cofactors: factor VIII New Comprehensive Biochemistry. 13: 35-57. DOI: 10.1016/S0167-7306(08)60047-2 |
0.34 |
|
| 1984 |
Fay PJ, Chavin SI, Malone JE, Schroeder D, Young FE, Marder VJ. The effect of carbohydrate depletion on procoagulant activity and in vivo survival of highly purified human factor VIII. Biochimica Et Biophysica Acta. 800: 152-8. PMID 6430352 DOI: 10.1016/0304-4165(84)90054-0 |
0.393 |
|
| 1983 |
LaDuca RJ, Fay PJ, Chuang C, McHenry CS, Bambara RA. Site-specific pausing of deoxyribonucleic acid synthesis catalyzed by four forms of Escherichia coli DNA polymerase III Biochemistry. 22: 5177-5188. PMID 6360204 DOI: 10.1021/Bi00291A018 |
0.611 |
|
| 1982 |
Fay PJ, Chavin SI, Schroeder D, Young FE, Marder VJ. Purification and characterization of a highly purified human factor VIII consisting of a single type of polypeptide chain. Proceedings of the National Academy of Sciences of the United States of America. 79: 7200-204. PMID 6818542 DOI: 10.1073/Pnas.79.23.7200 |
0.382 |
|
| 1980 |
Matson SW, Fay PJ, Bambara RA. Mechanism of inhibition of the Avian Myeloblastosis Virus deoxyribonucleic acid polymerase by adriamycin Biochemistry. 19: 2089-2096. PMID 6155137 DOI: 10.1021/Bi00551A014 |
0.728 |
|
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