Deborah S. Wuttke, Ph.D. - Publications

Chemistry and Biochemistry University of Colorado, Boulder, Boulder, CO, United States 
telomeres, telomerase

71 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Lloyd NR, Wuttke DS. Cyp33 binds AU-rich RNA motifs via an extended interface that competitively disrupts the gene repressive Cyp33-MLL1 interaction in vitro. Plos One. 16: e0237956. PMID 33606679 DOI: 10.1371/journal.pone.0237956  0.4
2019 Lewis KA, Altschuler SE, Wuttke DS. Measuring Low-Picomolar Apparent Binding Affinities by Minigel Electrophoretic Mobility Shift. Methods in Molecular Biology (Clifton, N.J.). 1855: 341-354. PMID 30426430 DOI: 10.1007/978-1-4939-8793-1_29  1
2018 Glustrom LW, Lyon KR, Paschini M, Reyes CM, Parsonnet NV, Toro TB, Lundblad V, Wuttke DS. Single-stranded telomere-binding protein employs a dual rheostat for binding affinity and specificity that drives function. Proceedings of the National Academy of Sciences of the United States of America. PMID 30249661 DOI: 10.1073/Pnas.1722147115  1
2018 Lloyd NR, Wuttke DS. Discrimination against RNA Backbones by a ssDNA Binding Protein. Structure (London, England : 1993). PMID 29681468 DOI: 10.1016/J.Str.2018.03.016  0.4
2017 McKercher MA, Guan X, Tan Z, Wuttke DS. Diversity in Peptide Recognition by the SH2 Domain of SH2B1. Proteins. PMID 29127727 DOI: 10.1002/Prot.25420  1
2017 Hom RA, Wuttke DS. Human CST Prefers G-Rich but Not Necessarily Telomeric Sequences. Biochemistry. PMID 28726394 DOI: 10.1021/Acs.Biochem.7B00584  0.4
2017 McKercher MA, Guan X, Tan Z, Wuttke DS. Multimodal Recognition of Diverse Peptides by the C-Terminal SH2 Domain of PLCγ1. Biochemistry. PMID 28376302 DOI: 10.1021/Acs.Biochem.7B00023  1
2017 McKercher MA, Wuttke DS. Calorimetric Measurement of SH2 Domain Ligand Affinities. Methods in Molecular Biology (Clifton, N.J.). 1555: 291-305. PMID 28092039 DOI: 10.1007/978-1-4939-6762-9_16  1
2017 McKercher MA, Wuttke DS. NMR Chemical Shift Mapping of SH2 Peptide Interactions. Methods in Molecular Biology (Clifton, N.J.). 1555: 269-290. PMID 28092038 DOI: 10.1007/978-1-4939-6762-9_15  1
2016 Lloyd NR, Dickey TH, Hom RA, Wuttke DS. Tying Up the Ends: Plasticity in the Recognition of ssDNA at Telomeres. Biochemistry. PMID 27575340 DOI: 10.1021/Acs.Biochem.6B00496  1
2016 Pinzaru AM, Hom RA, Beal A, Phillips AF, Ni E, Cardozo T, Nair N, Choi J, Wuttke DS, Sfeir A, Denchi EL. Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis. Cell Reports. PMID 27239034 DOI: 10.1016/J.Celrep.2016.05.008  0.4
2014 Lloyd NR, Wuttke DS. Less is more: structures of difficult targets with minimal constraints. Structure (London, England : 1993). 22: 1223-4. PMID 25185825 DOI: 10.1016/J.Str.2014.08.004  1
2014 Dickey TH, Wuttke DS. The telomeric protein Pot1 from Schizosaccharomyces pombe binds ssDNA in two modes with differing 3' end availability. Nucleic Acids Research. 42: 9656-65. PMID 25074378 DOI: 10.1093/Nar/Gku680  1
2014 Rao T, Lubin JW, Armstrong GS, Tucey TM, Lundblad V, Wuttke DS. Structure of Est3 reveals a bimodal surface with differential roles in telomere replication. Proceedings of the National Academy of Sciences of the United States of America. 111: 214-8. PMID 24344315 DOI: 10.1073/Pnas.1316453111  1
2014 Lewis KA, Pfaff DA, Earley JN, Altschuler SE, Wuttke DS. The tenacious recognition of yeast telomere sequence by Cdc13 is fully exerted by a single OB-fold domain. Nucleic Acids Research. 42: 475-84. PMID 24057216 DOI: 10.1093/Nar/Gkt843  1
2013 Altschuler SE, Lewis KA, Wuttke DS. Practical strategies for the evaluation of high-affinity protein/nucleic acid interactions. Journal of Nucleic Acids Investigation. 4: 19-28. PMID 25197549 DOI: 10.4081/Jnai.2013.E3  1
2013 Dickey TH, Altschuler SE, Wuttke DS. Single-stranded DNA-binding proteins: multiple domains for multiple functions. Structure (London, England : 1993). 21: 1074-84. PMID 23823326 DOI: 10.1016/J.Str.2013.05.013  1
2013 Lubin JW, Rao T, Mandell EK, Wuttke DS, Lundblad V. Dissecting protein function: an efficient protocol for identifying separation-of-function mutations that encode structurally stable proteins. Genetics. 193: 715-25. PMID 23307900 DOI: 10.1534/Genetics.112.147801  1
2013 Dickey TH, McKercher MA, Wuttke DS. Nonspecific recognition is achieved in Pot1pC through the use of multiple binding modes. Structure (London, England : 1993). 21: 121-32. PMID 23201273 DOI: 10.1016/J.Str.2012.10.015  1
2012 Altschuler SE, Croy JE, Wuttke DS. A small molecule inhibitor of Pot1 binding to telomeric DNA. Biochemistry. 51: 7833-45. PMID 22978652 DOI: 10.1021/Bi300365K  1
2012 Lewis KA, Wuttke DS. Telomerase and telomere-associated proteins: structural insights into mechanism and evolution. Structure (London, England : 1993). 20: 28-39. PMID 22244753 DOI: 10.1016/J.Str.2011.10.017  1
2012 Braun LJ, Eldridge AM, Cummiskey J, Arthur KK, Wuttke DS. The role of adjuvant in mediating antigen structure and stability. Journal of Pharmaceutical Sciences. 101: 1391-9. PMID 22213631 DOI: 10.1002/Jps.23039  1
2011 Altschuler SE, Dickey TH, Wuttke DS. Schizosaccharomyces pombe protection of telomeres 1 utilizes alternate binding modes to accommodate different telomeric sequences. Biochemistry. 50: 7503-13. PMID 21815629 DOI: 10.1021/Bi200826A  1
2011 Mandell EK, Gelinas AD, Wuttke DS, Lundblad V. Sequence-specific binding to telomeric DNA is not a conserved property of the Cdc13 DNA binding domain. Biochemistry. 50: 6289-91. PMID 21668015 DOI: 10.1021/Bi2005448  1
2011 Alford JR, Fowler AC, Wuttke DS, Kerwin BA, Latypov RF, Carpenter JF, Randolph TW. Effect of benzyl alcohol on recombinant human interleukin-1 receptor antagonist structure and hydrogen-deuterium exchange. Journal of Pharmaceutical Sciences. 100: 4215-24. PMID 21557223 DOI: 10.1002/Jps.22601  1
2010 Lee J, Mandell EK, Rao T, Wuttke DS, Lundblad V. Investigating the role of the Est3 protein in yeast telomere replication. Nucleic Acids Research. 38: 2279-90. PMID 20047960 DOI: 10.1093/Nar/Gkp1173  1
2009 Gelinas AD, Paschini M, Reyes FE, Héroux A, Batey RT, Lundblad V, Wuttke DS. Telomere capping proteins are structurally related to RPA with an additional telomere-specific domain. Proceedings of the National Academy of Sciences of the United States of America. 106: 19298-303. PMID 19884503 DOI: 10.1073/Pnas.0909203106  1
2009 Croy JE, Altschuler SE, Grimm NE, Wuttke DS. Nonadditivity in the recognition of single-stranded DNA by the schizosaccharomyces pombe protection of telomeres 1 DNA-binding domain, Pot1-DBD. Biochemistry. 48: 6864-75. PMID 19518131 DOI: 10.1021/Bi900307X  1
2009 Croy JE, Wuttke DS. Insights into the dynamics of specific telomeric single-stranded DNA recognition by Pot1pN. Journal of Molecular Biology. 387: 935-48. PMID 19232358 DOI: 10.1016/J.Jmb.2009.02.016  1
2009 Zappulla DC, Roberts JN, Goodrich KJ, Cech TR, Wuttke DS. Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p. Nucleic Acids Research. 37: 354-67. PMID 19043074 DOI: 10.1093/Nar/Gkn830  1
2008 Croy JE, Fast JL, Grimm NE, Wuttke DS. Deciphering the mechanism of thermodynamic accommodation of telomeric oligonucleotide sequences by the Schizosaccharomyces pombe protection of telomeres 1 (Pot1pN) protein. Biochemistry. 47: 4345-58. PMID 18355038 DOI: 10.1021/Bi701778X  1
2008 Theobald DL, Wuttke DS. Accurate structural correlations from maximum likelihood superpositions. Plos Computational Biology. 4: e43. PMID 18282091 DOI: 10.1371/Journal.Pcbi.0040043  1
2008 Eldridge AM, Wuttke DS. Probing the mechanism of recognition of ssDNA by the Cdc13-DBD. Nucleic Acids Research. 36: 1624-33. PMID 18250086 DOI: 10.1093/Nar/Gkn017  1
2008 Alford JR, Kwok SC, Roberts JN, Wuttke DS, Kendrick BS, Carpenter JF, Randolph TW. High concentration formulations of recombinant human interleukin-1 receptor antagonist: I. Physical characterization. Journal of Pharmaceutical Sciences. 97: 3035-50. PMID 17973297 DOI: 10.1002/Jps.21199  1
2007 Strauss DM, Wuttke DS. Characterization of protein-protein interactions critical for poliovirus replication: analysis of 3AB and VPg binding to the RNA-dependent RNA polymerase. Journal of Virology. 81: 6369-78. PMID 17409142 DOI: 10.1128/Jvi.02252-06  1
2006 Theobald DL, Wuttke DS. Empirical Bayes hierarchical models for regularizing maximum likelihood estimation in the matrix Gaussian Procrustes problem. Proceedings of the National Academy of Sciences of the United States of America. 103: 18521-7. PMID 17130458 DOI: 10.1073/Pnas.0508445103  1
2006 Croy JE, Wuttke DS. Themes in ssDNA recognition by telomere-end protection proteins. Trends in Biochemical Sciences. 31: 516-25. PMID 16890443 DOI: 10.1016/J.Tibs.2006.07.004  1
2006 Croy JE, Podell ER, Wuttke DS. A new model for Schizosaccharomyces pombe telomere recognition: the telomeric single-stranded DNA-binding activity of Pot11-389. Journal of Molecular Biology. 361: 80-93. PMID 16842820 DOI: 10.1016/J.Jmb.2006.06.002  1
2006 Theobald DL, Wuttke DS. THESEUS: maximum likelihood superpositioning and analysis of macromolecular structures. Bioinformatics (Oxford, England). 22: 2171-2. PMID 16777907 DOI: 10.1093/Bioinformatics/Btl332  1
2006 Eldridge AM, Halsey WA, Wuttke DS. Identification of the determinants for the specific recognition of single-strand telomeric DNA by Cdc13. Biochemistry. 45: 871-9. PMID 16411763 DOI: 10.1021/Bi0512703  1
2005 Theobald DL, Wuttke DS. Divergent evolution within protein superfolds inferred from profile-based phylogenetics. Journal of Molecular Biology. 354: 722-37. PMID 16266719 DOI: 10.1016/J.Jmb.2005.08.071  1
2005 Jacobs SA, Podell ER, Wuttke DS, Cech TR. Soluble domains of telomerase reverse transcriptase identified by high-throughput screening. Protein Science : a Publication of the Protein Society. 14: 2051-8. PMID 16046627 DOI: 10.1110/Ps.051532105  1
2004 Theobald DL, Wuttke DS. Prediction of multiple tandem OB-fold domains in telomere end-binding proteins Pot1 and Cdc13. Structure (London, England : 1993). 12: 1877-9. PMID 15458635 DOI: 10.1016/J.Str.2004.07.015  1
2004 Mitton-Fry RM, Anderson EM, Theobald DL, Glustrom LW, Wuttke DS. Structural basis for telomeric single-stranded DNA recognition by yeast Cdc13. Journal of Molecular Biology. 338: 241-55. PMID 15066429 DOI: 10.1016/J.Jmb.2004.01.063  1
2004 Wuttke DS. Targeting the end; the structure of the Ku80 C-terminal domain. Structure (London, England : 1993). 12: 355-6. PMID 15016349 DOI: 10.1016/J.Str.2004.02.025  1
2003 Theobald DL, Cervantes RB, Lundblad V, Wuttke DS. Homology among telomeric end-protection proteins. Structure (London, England : 1993). 11: 1049-50. PMID 12962623 DOI: 10.1016/S0969-2126(03)00183-7  1
2003 Strauss DM, Glustrom LW, Wuttke DS. Towards an understanding of the poliovirus replication complex: the solution structure of the soluble domain of the poliovirus 3A protein. Journal of Molecular Biology. 330: 225-34. PMID 12823963 DOI: 10.1016/S0022-2836(03)00577-1  1
2003 Anderson EM, Halsey WA, Wuttke DS. Site-directed mutagenesis reveals the thermodynamic requirements for single-stranded DNA recognition by the telomere-binding protein Cdc13. Biochemistry. 42: 3751-8. PMID 12667066 DOI: 10.1021/Bi027047C  1
2003 Theobald DL, Mitton-Fry RM, Wuttke DS. Nucleic acid recognition by OB-fold proteins. Annual Review of Biophysics and Biomolecular Structure. 32: 115-33. PMID 12598368 DOI: 10.1146/Annurev.Biophys.32.110601.142506  1
2003 Ojennus DD, Lehto SE, Wuttke DS. Electrostatic interactions in the reconstitution of an SH2 domain from constituent peptide fragments. Protein Science : a Publication of the Protein Society. 12: 44-55. PMID 12493827 DOI: 10.1110/Ps.0227903  1
2002 Anderson EM, Halsey WA, Wuttke DS. Delineation of the high-affinity single-stranded telomeric DNA-binding domain of Saccharomyces cerevisiae Cdc13. Nucleic Acids Research. 30: 4305-13. PMID 12364610 DOI: 10.1093/Nar/Gkf554  1
2002 Glustrom LW, Mitton-Fry RM, Wuttke DS. Re: 1,1-Dichloro-2,2-bis-(p-chlorophenyl)ethylene and polychlorinated biphenyls and breast cancer: combined analysis of five U.S. studies. Journal of the National Cancer Institute. 94: 1337-8; author reply. PMID 12208902 DOI: 10.1093/Jnci/94.17.1337  1
2002 Mitton-Fry RM, Wuttke DS. 1H, 13C and 15N resonance assignments of the DNA-binding domain of the essential protein Cdc13 complexed with single-stranded telomeric DNA. Journal of Biomolecular Nmr. 22: 379-80. PMID 12018489 DOI: 10.1023/A:1014932727059  1
2002 Mitton-Fry RM, Anderson EM, Hughes TR, Lundblad V, Wuttke DS. Conserved structure for single-stranded telomeric DNA recognition. Science (New York, N.Y.). 296: 145-7. PMID 11935027 DOI: 10.1126/Science.1068799  1
2001 Ojennus DD, Fleissner MR, Wuttke DS. Reconstitution of a native-like SH2 domain from disordered peptide fragments examined by multidimensional heteronuclear NMR. Protein Science : a Publication of the Protein Society. 10: 2162-75. PMID 11604523 DOI: 10.1110/Ps.18701  1
1999 Dahlke Ojennus D, Mitton-Fry RM, Wuttke DS. Induced alignment and measurement of dipolar couplings of an SH2 domain through direct binding with filamentous phage. Journal of Biomolecular Nmr. 14: 175-9. PMID 21080256 DOI: 10.1023/A:1008304332574  1
1998 Foster MP, Wuttke DS, Clemens KR, Jahnke W, Radhakrishnan I, Tennant L, Reymond M, Chung J, Wright PE. Chemical shift as a probe of molecular interfaces: NMR studies of DNA binding by the three amino-terminal zinc finger domains from transcription factor IIIA. Journal of Biomolecular Nmr. 12: 51-71. PMID 9729788 DOI: 10.1023/A:1008290631575  1
1997 Wuttke DS, Foster MP, Case DA, Gottesfeld JM, Wright PE. Solution structure of the first three zinc fingers of TFIIIA bound to the cognate DNA sequence: determinants of affinity and sequence specificity. Journal of Molecular Biology. 273: 183-206. PMID 9367756 DOI: 10.1006/Jmbi.1997.1291  1
1997 Foster MP, Wuttke DS, Radhakrishnan I, Case DA, Gottesfeld JM, Wright PE. Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA. Nature Structural Biology. 4: 605-8. PMID 9253405 DOI: 10.1038/Nsb0897-605  1
1997 Foster M, Wuttke DOS, Radhakrishnan I, Fwright P. Structure and dynamics in molecular recognition: NMR studies of tfiiia zinc fingers 1-3 complexed to a 15 base pair dna recognition sequence Faseb Journal. 11: A833.  1
1995 Bjerrum MJ, Casimiro DR, Chang IJ, Di Bilio AJ, Gray HB, Hill MG, Langen R, Mines GA, Skov LK, Winkler JR. Electron transfer in ruthenium-modified proteins. Journal of Bioenergetics and Biomembranes. 27: 295-302. PMID 8847343 DOI: 10.1007/Bf02110099  1
1994 Meier M, van Eldik R, Chang IJ, Mines GA, Wuttke DS, Winkler JR, Gray HB. Pressure Effects on the Rates of Intramolecular Electron Transfer in Ruthenium-Modified Cytochrome c. Role of the Intervening Medium in Tuning Distant Fe2+:Ru3+ Electronic Couplings Journal of the American Chemical Society. 116: 1577-1578. DOI: 10.1021/Ja00083A056  1
1994 Meier M, Van Eldik R, Chang IJ, Mines GA, Wuttke DS, Winkler JR, Gray HB. Pressure effects on the rates of intramolecular electron transfer in ruthenium-modified cytochrome c. Role of the intervening medium in tuning distant Fe2+:Ru3+ electronic couplings Journal of the American Chemical Society. 116: 1577-1578.  1
1993 Wuttke DS, Gray HB, Fisher SL, Imperiali B. Semisynthesis of bipyridyl-alanine cytochrome c mutants : novel proteins with enhanced electron-transfer properties Journal of the American Chemical Society. 115: 8455-8456. DOI: 10.1021/Ja00071A068  1
1993 Wuttke DS, Gray HB. Protein engineering as a tool for understanding electron transfer. Current Opinion in Structural Biology 1993, 3:555-563 Current Opinion in Structural Biology. 3: 555-563. DOI: 10.1016/0959-440X(93)90083-W  1
1993 Wuttke DS, Gray HB, Fisher SL, Imperial B. Semisynthesis of bipyridyl-alanine cytochrome c mutants: Novel protein structures with enhanced electron-transfer properties. Journal of Inorganic Biochemistry. 51: 235. DOI: 10.1016/0162-0134(93)85269-E  1
1993 Wuttke DS, Gray HB, Fisher SL, Imperiali B. Semisynthesis of bipyridyl-alanine cytochrome c mutants: Novel proteins with enhanced electron-transfer properties Journal of the American Chemical Society. 115: 8455-8456.  1
1992 Wuttke DS, Bjerrum MJ, Winkler JR, Gray HB. Electron-tunneling pathways in cytochrome C. Science (New York, N.Y.). 256: 1007-9. PMID 17795005 DOI: 10.1126/Science.256.5059.1007  1
1992 Wuttke DS, Bjerrum MJ, Chang I, Winkler JR, Gray HB. Electron tunneling in ruthenium-modified cytochromec Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1101: 168-170. DOI: 10.1016/0005-2728(92)90204-F  1
1992 Wuttke DS, Bjerrum MJ, Chang IJ, Winkler JR, Gray HB. Electron tunneling in ruthenium-modified cytochrome c Bba - Bioenergetics. 1101: 168-170.  1
1991 Wuttke DS, Gray HB. Intramolecular electron transfer in semisynthetic His 72 cytochrome C. Journal of Inorganic Biochemistry. 43: 98. DOI: 10.1016/0162-0134(91)84094-P  1
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