| Year |
Citation |
Score |
| 2024 |
Shulgina Y, Trinidad MI, Langeberg CJ, Nisonoff H, Chithrananda S, Skopintsev P, Nissley AJ, Patel J, Boger RS, Shi H, Yoon PH, Doherty EE, Pande T, Iyer AM, Doudna JA, et al. RNA language models predict mutations that improve RNA function. Biorxiv : the Preprint Server For Biology. PMID 38617247 DOI: 10.1101/2024.04.05.588317 |
0.798 |
|
| 2024 |
Enustun E, Armbruster EG, Lee J, Zhang S, Yee BA, Malukhina K, Gu Y, Deep A, Naritomi JT, Liang Q, Aigner S, Adler BA, Cress BF, Doudna JA, Chaikeeratisak V, et al. A phage nucleus-associated RNA-binding protein is required for jumbo phage infection. Nucleic Acids Research. PMID 38554115 DOI: 10.1093/nar/gkae216 |
0.355 |
|
| 2024 |
Hamilton JR, Chen E, Perez BS, Sandoval Espinoza CR, Kang MH, Trinidad M, Ngo W, Doudna JA. In vivo human T cell engineering with enveloped delivery vehicles. Nature Biotechnology. PMID 38212493 DOI: 10.1038/s41587-023-02085-z |
0.669 |
|
| 2023 |
Lou YC, Rubin BE, Schoelmerich MC, DiMarco KS, Borges AL, Rovinsky R, Song L, Doudna JA, Banfield JF. Infant microbiome cultivation and metagenomic analysis reveal Bifidobacterium 2'-fucosyllactose utilization can be facilitated by coexisting species. Nature Communications. 14: 7417. PMID 37973815 DOI: 10.1038/s41467-023-43279-y |
0.355 |
|
| 2023 |
Yoon PH, Skopintsev P, Shi H, Chen L, Adler BA, Al-Shimary M, Craig RJ, Loi KJ, DeTurk EC, Li Z, Amerasekera J, Trinidad M, Nisonoff H, Chen K, Lahiri A, ... ... Doudna JA, et al. Eukaryotic RNA-guided endonucleases evolved from a unique clade of bacterial enzymes. Nucleic Acids Research. PMID 37971304 DOI: 10.1093/nar/gkad1053 |
0.815 |
|
| 2023 |
Adler BA, Trinidad MI, Bellieny-Rabelo D, Zhang E, Karp HM, Skopintsev P, Thornton BW, Weissman RF, Yoon PH, Chen L, Hessler T, Eggers AR, Colognori D, Boger R, Doherty EE, ... ... Doudna JA, et al. CasPEDIA Database: a functional classification system for class 2 CRISPR-Cas enzymes. Nucleic Acids Research. PMID 37889041 DOI: 10.1093/nar/gkad890 |
0.8 |
|
| 2023 |
Adly AN, Bi M, Carlson CR, Syed AM, Ciling A, Doudna JA, Cheng Y, Morgan DO. Assembly of SARS-CoV-2 ribonucleosomes by truncated N* variant of the nucleocapsid protein. The Journal of Biological Chemistry. 105362. PMID 37863261 DOI: 10.1016/j.jbc.2023.105362 |
0.303 |
|
| 2023 |
Enustun E, Armbruster EG, Lee J, Zhang S, Yee BA, Gu Y, Deep A, Naritomi JT, Liang Q, Aigner S, Adler BA, Cress BF, Doudna JA, Chaikeeratisak V, Cleveland DW, et al. A phage nucleus-associated RNA-binding protein is required for jumbo phage infection. Biorxiv : the Preprint Server For Biology. PMID 37790334 DOI: 10.1101/2023.09.22.559000 |
0.648 |
|
| 2023 |
Armbruster EG, Lee J, Hutchings J, VanderWal AR, Enustun E, Adler BA, Aindow A, Deep A, Rodriguez ZK, Morgan CJ, Ghassemian M, Charles E, Cress BF, Savage DF, Doudna JA, et al. Sequential membrane- and protein-bound organelles compartmentalize genomes during phage infection. Biorxiv : the Preprint Server For Biology. PMID 37781618 DOI: 10.1101/2023.09.20.558163 |
0.56 |
|
| 2023 |
Yoon PH, Skopintsev P, Shi H, Chen LX, Adler BA, Al-Shimary M, Craig RJ, Li Z, Amerasekera J, Trinidad M, Nisonoff H, Chen K, Lahiri A, Boger R, Jacobsen S, ... ... Doudna JA, et al. Eukaryotic RNA-guided endonucleases evolved from a unique clade of bacterial enzymes. Biorxiv : the Preprint Server For Biology. PMID 37609353 DOI: 10.1101/2023.08.09.552727 |
0.823 |
|
| 2023 |
Stahl EC, Sabo JK, Kang MH, Allen R, Applegate E, Kim SE, Kwon Y, Seth A, Lemus N, Salinas-Rios V, Soczek KM, Trinidad M, Vo LT, Jeans C, Wozniak A, ... ... Doudna JA, et al. Genome editing in the mouse brain with minimally immunogenic Cas9 RNPs. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 37403358 DOI: 10.1016/j.ymthe.2023.06.019 |
0.608 |
|
| 2023 |
Wang JY, Tuck OT, Skopintsev P, Soczek KM, Li G, Al-Shayeb B, Zhou J, Doudna JA. Genome expansion by a CRISPR trimmer-integrase. Nature. 618: 855-861. PMID 37316664 DOI: 10.1038/s41586-023-06178-2 |
0.817 |
|
| 2023 |
Taha TY, Chen IP, Hayashi JM, Tabata T, Walcott K, Kimmerly GR, Syed AM, Ciling A, Suryawanshi RK, Martin HS, Bach BH, Tsou CL, Montano M, Khalid MM, Sreekumar BK, ... ... Doudna JA, et al. Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA.1 variant through NSP6. Nature Communications. 14: 2308. PMID 37085489 DOI: 10.1038/s41467-023-37787-0 |
0.389 |
|
| 2023 |
Tsuchida CA, Brandes N, Bueno R, Trinidad M, Mazumder T, Yu B, Hwang B, Chang C, Liu J, Sun Y, Hopkins CR, Parker KR, Qi Y, Satpathy AT, Stadtmauer EA, ... ... Doudna JA, et al. Mitigation of chromosome loss in clinical CRISPR-Cas9-engineered T cells. Biorxiv : the Preprint Server For Biology. PMID 36993359 DOI: 10.1101/2023.03.22.533709 |
0.238 |
|
| 2023 |
Taha TY, Chen IP, Hayashi JM, Tabata T, Walcott K, Kimmerly GR, Syed AM, Ciling A, Suryawanshi RK, Martin HS, Bach BH, Tsou CL, Montano M, Khalid MM, Sreekumar BK, ... ... Doudna JA, et al. Rapid assembly of SARS-CoV-2 genomes reveals attenuation of the Omicron BA.1 variant through NSP6. Biorxiv : the Preprint Server For Biology. PMID 36798416 DOI: 10.1101/2023.01.31.525914 |
0.388 |
|
| 2023 |
Yoon PH, Adler BA, Doudna JA. To TnpB or not TnpB? Cas12 is the answer. Nature Chemical Biology. 19: 263-264. PMID 36797405 DOI: 10.1038/s41589-022-01243-9 |
0.245 |
|
| 2023 |
Colognori D, Trinidad M, Doudna JA. Precise transcript targeting by CRISPR-Csm complexes. Nature Biotechnology. PMID 36690762 DOI: 10.1038/s41587-022-01649-9 |
0.526 |
|
| 2023 |
Wang JY, Doudna JA. CRISPR technology: A decade of genome editing is only the beginning. Science (New York, N.Y.). 379: eadd8643. PMID 36656942 DOI: 10.1126/science.add8643 |
0.269 |
|
| 2023 |
Li Z, Zhong Z, Wu Z, Pausch P, Al-Shayeb B, Amerasekera J, Doudna JA, Jacobsen SE. Genome editing in plants using the compact editor CasΦ. Proceedings of the National Academy of Sciences of the United States of America. 120: e2216822120. PMID 36652483 DOI: 10.1073/pnas.2216822120 |
0.784 |
|
| 2022 |
Ma E, Chen K, Shi H, Stahl EC, Adler B, Trinidad M, Liu J, Zhou K, Ye J, Doudna JA. Improved genome editing by an engineered CRISPR-Cas12a. Nucleic Acids Research. PMID 36537251 DOI: 10.1093/nar/gkac1192 |
0.41 |
|
| 2022 |
Chen E, Lin-Shiao E, Trinidad M, Saffari Doost M, Colognori D, Doudna JA. Decorating chromatin for enhanced genome editing using CRISPR-Cas9. Proceedings of the National Academy of Sciences of the United States of America. 119: e2204259119. PMID 36459645 DOI: 10.1073/pnas.2204259119 |
0.415 |
|
| 2022 |
Al-Shayeb B, Skopintsev P, Soczek KM, Stahl EC, Li Z, Groover E, Smock D, Eggers AR, Pausch P, Cress BF, Huang CJ, Staskawicz B, Savage DF, Jacobsen SE, Banfield JF, ... Doudna JA, et al. Diverse virus-encoded CRISPR-Cas systems include streamlined genome editors. Cell. 185: 4574-4586.e16. PMID 36423580 DOI: 10.1016/j.cell.2022.10.020 |
0.834 |
|
| 2022 |
Adler BA, Hessler T, Cress BF, Lahiri A, Mutalik VK, Barrangou R, Banfield J, Doudna JA. Broad-spectrum CRISPR-Cas13a enables efficient phage genome editing. Nature Microbiology. PMID 36316451 DOI: 10.1038/s41564-022-01258-x |
0.648 |
|
| 2022 |
Al-Shayeb B, Schoelmerich MC, West-Roberts J, Valentin-Alvarado LE, Sachdeva R, Mullen S, Crits-Christoph A, Wilkins MJ, Williams KH, Doudna JA, Banfield JF. Borgs are giant genetic elements with potential to expand metabolic capacity. Nature. PMID 36261517 DOI: 10.1038/s41586-022-05256-1 |
0.774 |
|
| 2022 |
Barger CJ, Suwala AK, Soczek KM, Wang AS, Kim MY, Hong C, Doudna JA, Chang SM, Phillips JJ, Solomon DA, Costello JF. Conserved features of TERT promoter duplications reveal an activation mechanism that mimics hotspot mutations in cancer. Nature Communications. 13: 5430. PMID 36114166 DOI: 10.1038/s41467-022-33099-x |
0.268 |
|
| 2022 |
Kan MJ, Doudna JA. Treatment of Genetic Diseases With CRISPR Genome Editing. Jama. 328: 980-981. PMID 36098733 DOI: 10.1001/jama.2022.13468 |
0.256 |
|
| 2022 |
Chandrasekaran SS, Agrawal S, Fanton A, Jangid AR, Charrez B, Escajeda AM, Son S, Mcintosh R, Tran H, Bhuiya A, de León Derby MD, Switz NA, Armstrong M, Harris AR, Prywes N, ... ... Doudna JA, et al. Rapid detection of SARS-CoV-2 RNA in saliva via Cas13. Nature Biomedical Engineering. PMID 35953650 DOI: 10.1038/s41551-022-00917-y |
0.807 |
|
| 2022 |
Otoupal PB, Cress BF, Doudna JA, Schoeniger JS. CRISPR-RNAa: targeted activation of translation using dCas13 fusions to translation initiation factors. Nucleic Acids Research. PMID 35950485 DOI: 10.1093/nar/gkac680 |
0.345 |
|
| 2022 |
Syed AM, Ciling A, Taha TY, Chen IP, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Suryawanshi R, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, ... ... Doudna JA, et al. Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles. Proceedings of the National Academy of Sciences of the United States of America. 119: e2200592119. PMID 35858386 DOI: 10.1073/pnas.2200592119 |
0.252 |
|
| 2022 |
Huang CJ, Adler BA, Doudna JA. A naturally DNase-free CRISPR-Cas12c enzyme silences gene expression. Molecular Cell. 82: 2148-2160.e4. PMID 35659325 DOI: 10.1016/j.molcel.2022.04.020 |
0.473 |
|
| 2022 |
Suryawanshi RK, Chen IP, Ma T, Syed AM, Brazer N, Saldhi P, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Montano M, Gascon R, Tsou CL, ... ... Doudna JA, et al. Limited cross-variant immunity from SARS-CoV-2 Omicron without vaccination. Nature. PMID 35584773 DOI: 10.1038/s41586-022-04865-0 |
0.214 |
|
| 2022 |
Wang JY, Pausch P, Doudna JA. Structural biology of CRISPR-Cas immunity and genome editing enzymes. Nature Reviews. Microbiology. PMID 35562427 DOI: 10.1038/s41579-022-00739-4 |
0.377 |
|
| 2022 |
Cofsky JC, Knott GJ, Gee CL, Doudna JA. Crystal structure of an RNA/DNA strand exchange junction. Plos One. 17: e0263547. PMID 35436289 DOI: 10.1371/journal.pone.0263547 |
0.736 |
|
| 2022 |
Servellita V, Syed AM, Morris MK, Brazer N, Saldhi P, Garcia-Knight M, Sreekumar B, Khalid MM, Ciling A, Chen PY, Kumar GR, Gliwa AS, Nguyen J, Sotomayor-Gonzalez A, Zhang Y, ... ... Doudna J, et al. Neutralizing immunity in vaccine breakthrough infections from the SARS-CoV-2 Omicron and Delta variants. Cell. PMID 35429436 DOI: 10.1016/j.cell.2022.03.019 |
0.23 |
|
| 2022 |
Cofsky JC, Soczek KM, Knott GJ, Nogales E, Doudna JA. CRISPR-Cas9 bends and twists DNA to read its sequence. Nature Structural & Molecular Biology. 29: 395-402. PMID 35422516 DOI: 10.1038/s41594-022-00756-0 |
0.775 |
|
| 2022 |
Hiatt J, Hultquist JF, McGregor MJ, Bouhaddou M, Leenay RT, Simons LM, Young JM, Haas P, Roth TL, Tobin V, Wojcechowskyj JA, Woo JM, Rathore U, Cavero DA, Shifrut E, ... ... Doudna JA, et al. A functional map of HIV-host interactions in primary human T cells. Nature Communications. 13: 1752. PMID 35365639 DOI: 10.1038/s41467-022-29346-w |
0.263 |
|
| 2022 |
Tsuchida CA, Zhang S, Doost MS, Zhao Y, Wang J, O'Brien E, Fang H, Li CP, Li D, Hai ZY, Chuck J, Brötzmann J, Vartoumian A, Burstein D, Chen XW, ... ... Doudna JA, et al. Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity. Molecular Cell. PMID 35219382 DOI: 10.1016/j.molcel.2022.02.002 |
0.667 |
|
| 2022 |
Lin-Shiao E, Pfeifer WG, Shy BR, Saffari Doost M, Chen E, Vykunta VS, Hamilton JR, Stahl EC, Lopez DM, Sandoval Espinoza CR, Deyanov AE, Lew RJ, Poirer MG, Marson A, Castro CE, ... Doudna JA, et al. CRISPR-Cas9-mediated nuclear transport and genomic integration of nanostructured genes in human primary cells. Nucleic Acids Research. PMID 35104875 DOI: 10.1093/nar/gkac049 |
0.702 |
|
| 2022 |
Suryawanshi RK, Chen IP, Ma T, Syed AM, Simoneau CR, Ciling A, Khalid MM, Sreekumar B, Chen PY, George AF, Kumar GR, Montano M, Garcia-Knight MA, Brazer N, Saldhi P, ... ... Doudna J, et al. Limited cross-variant immunity after infection with the SARS-CoV-2 Omicron variant without vaccination. Medrxiv : the Preprint Server For Health Sciences. PMID 35075459 DOI: 10.1101/2022.01.13.22269243 |
0.225 |
|
| 2022 |
Syed AM, Ciling A, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Spraggon L, ... ... Doudna JA, et al. Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles. Medrxiv : the Preprint Server For Health Sciences. PMID 34981067 DOI: 10.1101/2021.12.20.21268048 |
0.245 |
|
| 2021 |
Rubin BE, Diamond S, Cress BF, Crits-Christoph A, Lou YC, Borges AL, Shivram H, He C, Xu M, Zhou Z, Smith SJ, Rovinsky R, Smock DCJ, Tang K, Owens TK, ... ... Doudna JA, et al. Species- and site-specific genome editing in complex bacterial communities. Nature Microbiology. PMID 34873292 DOI: 10.1038/s41564-021-01014-7 |
0.8 |
|
| 2021 |
Brook CE, Northrup GR, Ehrenberg AJ, Doudna JA, Boots M. Optimizing COVID-19 control with asymptomatic surveillance testing in a university environment. Epidemics. 37: 100527. PMID 34814094 DOI: 10.1016/j.epidem.2021.100527 |
0.649 |
|
| 2021 |
Stahl EC, Gopez AR, Tsuchida CA, Fan VB, Moehle EA, Witkowsky LB, Hamilton JR, Lin-Shiao E, McElroy M, McDevitt SL, Ciling A, Tsui CK, Pestal K, Gildea HK, Keller A, ... ... Doudna JA, et al. LuNER: Multiplexed SARS-CoV-2 detection in clinical swab and wastewater samples. Plos One. 16: e0258263. PMID 34758033 DOI: 10.1371/journal.pone.0258263 |
0.773 |
|
| 2021 |
Syed AM, Taha TY, Tabata T, Chen IP, Ciling A, Khalid MM, Sreekumar B, Chen PY, Hayashi JM, Soczek KM, Ott M, Doudna JA. Rapid assessment of SARS-CoV-2 evolved variants using virus-like particles. Science (New York, N.Y.). eabl6184. PMID 34735219 DOI: 10.1126/science.abl6184 |
0.217 |
|
| 2021 |
Liu TY, Knott GJ, Smock DCJ, Desmarais JJ, Son S, Bhuiya A, Jakhanwal S, Prywes N, Agrawal S, Díaz de León Derby M, Switz NA, Armstrong M, Harris AR, Charles EJ, Thornton BW, ... ... Doudna JA, et al. Publisher Correction: Accelerated RNA detection using tandem CRISPR nucleases. Nature Chemical Biology. PMID 34616098 DOI: 10.1038/s41589-021-00882-8 |
0.832 |
|
| 2021 |
Shams A, Higgins SA, Fellmann C, Laughlin TG, Oakes BL, Lew R, Kim S, Lukarska M, Arnold M, Staahl BT, Doudna JA, Savage DF. Comprehensive deletion landscape of CRISPR-Cas9 identifies minimal RNA-guided DNA-binding modules. Nature Communications. 12: 5664. PMID 34580310 DOI: 10.1038/s41467-021-25992-8 |
0.82 |
|
| 2021 |
Nalefski EA, Patel N, Leung PJY, Islam Z, Kooistra RM, Parikh I, Marion E, Knott GJ, Doudna JA, Le Ny AM, Madan D. Kinetic analysis of Cas12a and Cas13a RNA-Guided nucleases for development of improved CRISPR-Based diagnostics. Iscience. 24: 102996. PMID 34505008 DOI: 10.1016/j.isci.2021.102996 |
0.753 |
|
| 2021 |
Mogilevsky CS, Lobba MJ, Brauer DD, Marmelstein AM, Maza JC, Gleason JM, Doudna JA, Francis MB. Synthesis of Multi-Protein Complexes through Charge-Directed Sequential Activation of Tyrosine Residues. Journal of the American Chemical Society. PMID 34382787 DOI: 10.1021/jacs.1c03079 |
0.331 |
|
| 2021 |
Pausch P, Soczek KM, Herbst DA, Tsuchida CA, Al-Shayeb B, Banfield JF, Nogales E, Doudna JA. DNA interference states of the hypercompact CRISPR-CasΦ effector. Nature Structural & Molecular Biology. 28: 652-661. PMID 34381246 DOI: 10.1038/s41594-021-00632-3 |
0.824 |
|
| 2021 |
Liu TY, Knott GJ, Smock DCJ, Desmarais JJ, Son S, Bhuiya A, Jakhanwal S, Prywes N, Agrawal S, Díaz de León Derby M, Switz NA, Armstrong M, Harris AR, Charles EJ, Thornton BW, ... ... Doudna JA, et al. Accelerated RNA detection using tandem CRISPR nucleases. Nature Chemical Biology. PMID 34354262 DOI: 10.1038/s41589-021-00842-2 |
0.839 |
|
| 2021 |
Hamilton JR, Stahl EC, Tsuchida CA, Lin-Shiao E, Tsui CK, Pestal K, Gildea HK, Witkowsky LB, Moehle EA, McDevitt SL, McElroy M, Keller A, Sylvain I, Hirsh A, Ciling A, ... ... Doudna JA, et al. Robotic RNA extraction for SARS-CoV-2 surveillance using saliva samples. Plos One. 16: e0255690. PMID 34351984 DOI: 10.1371/journal.pone.0255690 |
0.804 |
|
| 2021 |
Shim H, Shivram H, Lei S, Doudna JA, Banfield JF. Diverse ATPase Proteins in Mobilomes Constitute a Large Potential Sink for Prokaryotic Host ATP. Frontiers in Microbiology. 12: 691847. PMID 34305853 DOI: 10.3389/fmicb.2021.691847 |
0.798 |
|
| 2021 |
Hamilton JR, Tsuchida CA, Nguyen DN, Shy BR, McGarrigle ER, Sandoval Espinoza CR, Carr D, Blaeschke F, Marson A, Doudna JA. Targeted delivery of CRISPR-Cas9 and transgenes enables complex immune cell engineering. Cell Reports. 35: 109207. PMID 34077734 DOI: 10.1016/j.celrep.2021.109207 |
0.664 |
|
| 2021 |
Ehrenberg AJ, Moehle EA, Brook CE, Doudna Cate AH, Witkowsky LB, Sachdeva R, Hirsh A, Barry K, Hamilton JR, Lin-Shiao E, McDevitt S, Valentin-Alvarado L, Letourneau KN, Hunter L, Keller A, ... ... Doudna JA, et al. Launching a saliva-based SARS-CoV-2 surveillance testing program on a university campus. Plos One. 16: e0251296. PMID 34038425 DOI: 10.1371/journal.pone.0251296 |
0.756 |
|
| 2021 |
Wang JY, Hoel CM, Al-Shayeb B, Banfield JF, Brohawn SG, Doudna JA. Structural coordination between active sites of a CRISPR reverse transcriptase-integrase complex. Nature Communications. 12: 2571. PMID 33958590 DOI: 10.1038/s41467-021-22900-y |
0.833 |
|
| 2021 |
Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, ... ... Doudna JA, et al. The NIH Somatic Cell Genome Editing program. Nature. 592: 195-204. PMID 33828315 DOI: 10.1038/s41586-021-03191-1 |
0.617 |
|
| 2021 |
Liu TY, Knott GJ, Smock DCJ, Desmarais JJ, Son S, Bhuiya A, Jakhanwal S, Prywes N, Agrawal S, de León Derby MD, Switz NA, Armstrong M, Harris AR, Charles EJ, Thornton BW, ... ... Doudna JA, et al. Accelerated RNA detection using tandem CRISPR nucleases. Medrxiv : the Preprint Server For Health Sciences. PMID 33791736 DOI: 10.1101/2021.03.19.21253328 |
0.84 |
|
| 2021 |
Amen AM, Fellmann C, Soczek KM, Ren SM, Lew RJ, Knott GJ, Park JE, McKinney AM, Mancini A, Doudna JA, Costello JF. Cancer-specific loss of activation sensitizes glioblastoma to DNA damage. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33758097 DOI: 10.1073/pnas.2008772118 |
0.777 |
|
| 2021 |
Jakhanwal S, Cress BF, Maguin P, Lobba MJ, Marraffini LA, Doudna JA. A CRISPR-Cas9-integrase complex generates precise DNA fragments for genome integration. Nucleic Acids Research. PMID 33693715 DOI: 10.1093/nar/gkab123 |
0.499 |
|
| 2021 |
Boyle EA, Becker WR, Bai HB, Chen JS, Doudna JA, Greenleaf WJ. Quantification of Cas9 binding and cleavage across diverse guide sequences maps landscapes of target engagement. Science Advances. 7. PMID 33608277 DOI: 10.1126/sciadv.abe5496 |
0.422 |
|
| 2021 |
Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell. 184: 844. PMID 33545038 DOI: 10.1016/j.cell.2021.01.019 |
0.598 |
|
| 2021 |
Hamilton JR, Stahl EC, Tsuchida CA, Lin-Shiao E, Tsui CK, Pestal K, Gildea HK, Witkowsky LB, Moehle EA, McDevitt SL, McElroy M, Keller A, Sylvain I, Hirsh A, Ciling A, ... ... Doudna JA, et al. Robotic RNA extraction for SARS-CoV-2 surveillance using saliva samples. Medrxiv : the Preprint Server For Health Sciences. PMID 33532798 DOI: 10.1101/2021.01.10.21249151 |
0.804 |
|
| 2021 |
He C, Keren R, Whittaker ML, Farag IF, Doudna JA, Cate JHD, Banfield JF. Genome-resolved metagenomics reveals site-specific diversity of episymbiotic CPR bacteria and DPANN archaea in groundwater ecosystems. Nature Microbiology. PMID 33495623 DOI: 10.1038/s41564-020-00840-5 |
0.486 |
|
| 2021 |
Brook CE, Northrup GR, Ehrenberg AJ, Doudna JA, Boots M. Optimizing COVID-19 control with asymptomatic surveillance testing in a university environment. Medrxiv : the Preprint Server For Health Sciences. PMID 33442708 DOI: 10.1101/2020.11.12.20230870 |
0.648 |
|
| 2021 |
Collins FS, Doudna JA, Lander ES, Rotimi CN. Human Molecular Genetics and Genomics - Important Advances and Exciting Possibilities. The New England Journal of Medicine. 384: 1-4. PMID 33393745 DOI: 10.1056/NEJMp2030694 |
0.259 |
|
| 2021 |
Shivram H, Cress BF, Knott GJ, Doudna JA. Controlling and enhancing CRISPR systems. Nature Chemical Biology. 17: 10-19. PMID 33328654 DOI: 10.1038/s41589-020-00700-7 |
0.789 |
|
| 2020 |
Cofsky JC, Doudna JA. Attachment of a P-phosphate to the 3' Terminus of a DNA Oligonucleotide. Bio-Protocol. 10: e3787. PMID 33659442 DOI: 10.21769/BioProtoc.3787 |
0.379 |
|
| 2020 |
Agrawal S, Fanton A, Chandrasekaran SS, Prywes N, Lukarska M, Biering SB, Smock DCJ, Mok A, Knott GJ, Van E, Dugan E, Kim S, Liu TY, Harris E, Stanley SA, ... ... Doudna JA, et al. Rapid detection of SARS-CoV-2 with Cas13. Medrxiv : the Preprint Server For Health Sciences. PMID 33354689 DOI: 10.1101/2020.12.14.20247874 |
0.801 |
|
| 2020 |
Stahl EC, Tsuchida CA, Hamilton JR, Lin-Shiao E, McDevitt SL, Moehle EA, Witkowsky LB, Tsui CK, Pestal K, Gildea HK, McElroy M, Keller A, Sylvain I, Williams C, Hirsh A, ... ... Doudna JA, et al. IGI-LuNER: single-well multiplexed RT-qPCR test for SARS-CoV-2. Medrxiv : the Preprint Server For Health Sciences. PMID 33330883 DOI: 10.1101/2020.12.10.20247338 |
0.774 |
|
| 2020 |
Noureddine A, Maestas-Olguin A, Saada EA, LaBauve AE, Agola JO, Baty KE, Howard T, Sabo JK, Espinoza CRS, Doudna JA, Schoeniger JS, Butler KS, Negrete OA, Brinker CJ, Serda RE. Corrigendum to "Engineering of monosized lipid-coated mesoporous silica nanoparticles for CRISPR delivery" Acta Biomaterialia (2020), 114, 358-368. Acta Biomaterialia. PMID 33309186 DOI: 10.1016/j.actbio.2020.11.038 |
0.192 |
|
| 2020 |
Fozouni P, Son S, Díaz de León Derby M, Knott GJ, Gray CN, D'Ambrosio MV, Zhao C, Switz NA, Kumar GR, Stephens SI, Boehm D, Tsou CL, Shu J, Bhuiya A, Armstrong M, ... ... Doudna JA, et al. Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy. Cell. PMID 33306959 DOI: 10.1016/j.cell.2020.12.001 |
0.802 |
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| 2020 |
Angrist M, Barrangou R, Baylis F, Brokowski C, Burgio G, Caplan A, Chapman CR, Church GM, Cook-Deegan R, Cwik B, Doudna JA, Evans JH, Greely HT, Hercher L, Hurlbut JB, et al. Reactions to the National Academies/Royal Society Report on . The Crispr Journal. 3: 332-349. PMID 33095048 DOI: 10.1089/crispr.2020.29106.man |
0.247 |
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| 2020 |
Lobba MJ, Fellmann C, Marmelstein AM, Maza JC, Kissman EN, Robinson SA, Staahl BT, Urnes C, Lew RJ, Mogilevsky CS, Doudna JA, Francis MB. Site-Specific Bioconjugation through Enzyme-Catalyzed Tyrosine-Cysteine Bond Formation. Acs Central Science. 6: 1564-1571. PMID 32999931 DOI: 10.1021/Acscentsci.0C00940 |
0.78 |
|
| 2020 |
Jones SK, Hawkins JA, Johnson NV, Jung C, Hu K, Rybarski JR, Chen JS, Doudna JA, Press WH, Finkelstein IJ. Massively parallel kinetic profiling of natural and engineered CRISPR nucleases. Nature Biotechnology. PMID 32895548 DOI: 10.1038/S41587-020-0646-5 |
0.524 |
|
| 2020 |
Liu TY, Doudna JA. Chemistry of Class 1 CRISPR-Cas effectors: binding, editing, and regulation. The Journal of Biological Chemistry. PMID 32817336 DOI: 10.1074/Jbc.Rev120.007034 |
0.719 |
|
| 2020 |
Lapinaite A, Knott GJ, Palumbo CM, Lin-Shiao E, Richter MF, Zhao KT, Beal PA, Liu DR, Doudna JA. DNA capture by a CRISPR-Cas9-guided adenine base editor. Science (New York, N.Y.). 369: 566-571. PMID 32732424 DOI: 10.1126/Science.Abb1390 |
0.806 |
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| 2020 |
Noureddine A, Maestas-Olguin A, Saada EA, LaBauve AE, Agola JO, Baty KE, Howard T, Sabo JK, Espinoza CRS, Doudna JA, Schoeniger JS, Butler KS, Negrete OA, Brinker CJ, Serda RE. Engineering of Monosized Lipid-Coated Mesoporous Silica Nanoparticles for CRISPR Delivery. Acta Biomaterialia. PMID 32702530 DOI: 10.1016/J.Actbio.2020.07.027 |
0.368 |
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| 2020 |
Pausch P, Al-Shayeb B, Bisom-Rapp E, Tsuchida CA, Li Z, Cress BF, Knott GJ, Jacobsen SE, Banfield JF, Doudna JA. CRISPR-CasΦ from huge phages is a hypercompact genome editor. Science (New York, N.Y.). 369: 333-337. PMID 32675376 DOI: 10.1126/Science.Abb1400 |
0.824 |
|
| 2020 |
Harrington LB, Ma E, Chen JS, Witte IP, Gertz D, Paez-Espino D, Al-Shayeb B, Kyrpides NC, Burstein D, Banfield JF, Doudna JA. A scoutRNA Is Required for Some Type V CRISPR-Cas Systems. Molecular Cell. PMID 32645367 DOI: 10.1016/J.Molcel.2020.06.022 |
0.847 |
|
| 2020 |
Cofsky JC, Karandur D, Huang CJ, Witte IP, Kuriyan J, Doudna JA. CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks. Elife. 9. PMID 32519675 DOI: 10.7554/Elife.55143 |
0.557 |
|
| 2020 |
Richter MF, Zhao KT, Eton E, Lapinaite A, Newby GA, Thuronyi BW, Wilson C, Koblan LW, Zeng J, Bauer DE, Doudna JA, Liu DR. Author Correction: Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity. Nature Biotechnology. PMID 32433548 DOI: 10.1038/S41587-020-0562-8 |
0.775 |
|
| 2020 |
Richter MF, Zhao KT, Eton E, Lapinaite A, Newby GA, Thuronyi BW, Wilson C, Koblan LW, Zeng J, Bauer DE, Doudna JA, Liu DR. Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity. Nature Biotechnology. PMID 32433547 DOI: 10.1038/S41587-020-0453-Z |
0.816 |
|
| 2020 |
Eitzinger S, Asif A, Watters KE, Iavarone AT, Knott GJ, Doudna JA, Minhas FUAA. Machine learning predicts new anti-CRISPR proteins. Nucleic Acids Research. PMID 32286628 DOI: 10.1093/Nar/Gkaa219 |
0.778 |
|
| 2020 |
Watters KE, Shivram H, Fellmann C, Lew RJ, McMahon B, Doudna JA. Potent CRISPR-Cas9 inhibitors from genomes. Proceedings of the National Academy of Sciences of the United States of America. PMID 32156733 DOI: 10.1073/Pnas.1917668117 |
0.811 |
|
| 2020 |
Ivanov IE, Wright AV, Cofsky JC, Aris KDP, Doudna JA, Bryant Z. Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling. Proceedings of the National Academy of Sciences of the United States of America. PMID 32123105 DOI: 10.1073/Pnas.1913445117 |
0.504 |
|
| 2020 |
Doudna JA. The promise and challenge of therapeutic genome editing. Nature. 578: 229-236. PMID 32051598 DOI: 10.1038/S41586-020-1978-5 |
0.409 |
|
| 2020 |
Al-Shayeb B, Sachdeva R, Chen LX, Ward F, Munk P, Devoto A, Castelle CJ, Olm MR, Bouma-Gregson K, Amano Y, He C, Méheust R, Brooks B, Thomas A, Lavy A, ... ... Doudna JA, et al. Clades of huge phages from across Earth's ecosystems. Nature. PMID 32051592 DOI: 10.1038/S41586-020-2007-4 |
0.815 |
|
| 2020 |
Hamilton JR, Doudna JA. Knocking out barriers to engineered cell activity. Science (New York, N.Y.). PMID 32029685 DOI: 10.1126/Science.Aba9844 |
0.668 |
|
| 2020 |
Cofsky JC, Karandur D, Huang CJ, Witte IP, Kuriyan J, Doudna JA. Author response: CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks Elife. DOI: 10.7554/Elife.55143.Sa2 |
0.373 |
|
| 2019 |
Doudna J. CRISPR's unwanted anniversary. Science (New York, N.Y.). 366: 777. PMID 31727803 DOI: 10.1126/Science.Aba1751 |
0.393 |
|
| 2019 |
Cao Y, Ma E, Cestellos-Blanco S, Qiu R, Su Y, Doudna JA, Yang P. Reply to Nathamgari et al.: Nanopore electroporation for intracellular delivery of biological macromolecules. Proceedings of the National Academy of Sciences of the United States of America. PMID 31662468 DOI: 10.1073/Pnas.1912715116 |
0.303 |
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| 2019 |
Knott GJ, Cress BF, Liu JJ, Thornton BW, Lew RJ, Al-Shayeb B, Rosenberg DJ, Hammel M, Adler BA, Lobba MJ, Xu M, Arkin AP, Fellmann C, Doudna JA. Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a. Elife. 8. PMID 31397669 DOI: 10.7554/Elife.49110 |
0.804 |
|
| 2019 |
Liu TY, Liu JJ, Aditham AJ, Nogales E, Doudna JA. Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble. Nature Communications. 10: 3001. PMID 31278272 DOI: 10.1038/S41467-019-10780-2 |
0.801 |
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| 2019 |
Thavalingam A, Cheng Z, Garcia B, Huang X, Shah M, Sun W, Wang M, Harrington L, Hwang S, Hidalgo-Reyes Y, Sontheimer EJ, Doudna J, Davidson AR, Moraes TF, Wang Y, et al. Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2. Nature Communications. 10: 2806. PMID 31243272 DOI: 10.1038/S41467-019-10577-3 |
0.459 |
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| 2019 |
Chen LX, Al-Shayeb B, Méheust R, Li WJ, Doudna JA, Banfield JF. Candidate Phyla Radiation Roizmanbacteria From Hot Springs Have Novel and Unexpectedly Abundant CRISPR-Cas Systems. Frontiers in Microbiology. 10: 928. PMID 31130929 DOI: 10.3389/Fmicb.2019.00928 |
0.798 |
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| 2019 |
Kundert K, Lucas JE, Watters KE, Fellmann C, Ng AH, Heineike BM, Fitzsimmons CM, Oakes BL, Qu J, Prasad N, Rosenberg OS, Savage DF, El-Samad H, Doudna JA, Kortemme T. Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs. Nature Communications. 10: 2127. PMID 31073154 DOI: 10.1038/S41467-019-09985-2 |
0.831 |
|
| 2019 |
Ricci CG, Chen JS, Miao Y, Jinek M, Doudna JA, McCammon JA, Palermo G. Deciphering Off-Target Effects in CRISPR-Cas9 through Accelerated Molecular Dynamics. Acs Central Science. 5: 651-662. PMID 31041385 DOI: 10.1021/Acscentsci.9B00020 |
0.496 |
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| 2019 |
Liu JJ, Orlova N, Oakes BL, Ma E, Spinner HB, Baney KLM, Chuck J, Tan D, Knott GJ, Harrington LB, Al-Shayeb B, Wagner A, Brötzmann J, Staahl BT, Taylor KL, ... ... Doudna JA, et al. Author Correction: CasX enzymes comprise a distinct family of RNA-guided genome editors. Nature. PMID 30944483 DOI: 10.1038/S41586-019-1084-8 |
0.799 |
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| 2019 |
Knott GJ, Thornton BW, Lobba MJ, Liu JJ, Al-Shayeb B, Watters KE, Doudna JA. Broad-spectrum enzymatic inhibition of CRISPR-Cas12a. Nature Structural & Molecular Biology. 26: 315-321. PMID 30936531 DOI: 10.1038/S41594-019-0208-Z |
0.837 |
|
| 2019 |
Cao Y, Ma E, Cestellos-Blanco S, Zhang B, Qiu R, Su Y, Doudna JA, Yang P. Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules. Proceedings of the National Academy of Sciences of the United States of America. PMID 30923112 DOI: 10.1073/Pnas.1818553116 |
0.404 |
|
| 2019 |
Liu JJ, Orlova N, Oakes BL, Ma E, Spinner HB, Baney KLM, Chuck J, Tan D, Knott GJ, Harrington LB, Al-Shayeb B, Wagner A, Brötzmann J, Staahl BT, Taylor KL, ... ... Doudna JA, et al. CasX enzymes comprise a distinct family of RNA-guided genome editors. Nature. PMID 30718774 DOI: 10.1038/S41586-019-0908-X |
0.853 |
|
| 2019 |
Heler R, Wright AV, Vucelja M, Doudna JA, Marraffini LA. Spacer Acquisition Rates Determine the Immunological Diversity of the Type II CRISPR-Cas Immune Response. Cell Host & Microbe. PMID 30709780 DOI: 10.1016/J.Chom.2018.12.016 |
0.444 |
|
| 2019 |
Wright AV, Wang JY, Burstein D, Harrington LB, Paez-Espino D, Kyrpides NC, Iavarone AT, Banfield JF, Doudna JA. A Functional Mini-Integrase in a Two-Protein-type V-C CRISPR System. Molecular Cell. PMID 30709710 DOI: 10.1016/J.Molcel.2018.12.015 |
0.593 |
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| 2019 |
Oakes BL, Fellmann C, Rishi H, Taylor KL, Ren SM, Nadler DC, Yokoo R, Arkin AP, Doudna JA, Savage DF. CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification. Cell. 176: 254-267.e16. PMID 30633905 DOI: 10.1016/J.Cell.2018.11.052 |
0.687 |
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| 2019 |
Hultquist JF, Hiatt J, Schumann K, McGregor MJ, Roth TL, Haas P, Doudna JA, Marson A, Krogan NJ. CRISPR-Cas9 genome engineering of primary CD4 T cells for the interrogation of HIV-host factor interactions. Nature Protocols. 14: 1-27. PMID 30559373 DOI: 10.1038/S41596-018-0069-7 |
0.376 |
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| 2019 |
Knott GJ, Cress BF, Liu J, Thornton BW, Lew RJ, Al-Shayeb B, Rosenberg DJ, Hammel M, Adler BA, Lobba MJ, Xu M, Arkin AP, Fellmann C, Doudna JA. Author response: Structural basis for AcrVA4 inhibition of specific CRISPR-Cas12a Elife. DOI: 10.7554/Elife.49110.037 |
0.776 |
|
| 2019 |
Amen A, Lew R, Ren S, McKinney A, Mancini A, Doudna J, Fellmann C, Costello J. GENE-43. TARGETING GABPb1L INHIBITS IN VIVO GROWTH OF TERT PROMOTER MUTANT GLIOBLASTOMA Neuro-Oncology. 21: vi106-vi107. DOI: 10.1093/Neuonc/Noz175.445 |
0.393 |
|
| 2019 |
Palermo G, Gravina Ricci C, Chen JS, Miao Y, Jinek M, Doudna JA, McCammon JA. Molecular Mechanism of Off-Target Effects in CRISPR-Cas9 Biophysical Journal. 116: 319a. DOI: 10.1016/J.Bpj.2018.11.1731 |
0.493 |
|
| 2018 |
Bondy-Denomy J, Davidson AR, Doudna JA, Fineran PC, Maxwell KL, Moineau S, Peng X, Sontheimer EJ, Wiedenheft B. A Unified Resource for Tracking Anti-CRISPR Names. The Crispr Journal. 1: 304-305. PMID 31021273 DOI: 10.1089/crispr.2018.0043 |
0.573 |
|
| 2018 |
Palermo G, Chen JS, Ricci CG, Rivalta I, Jinek M, Batista VS, Doudna JA, McCammon JA. Key role of the REC lobe during CRISPR-Cas9 activation by 'sensing', 'regulating', and 'locking' the catalytic HNH domain. Quarterly Reviews of Biophysics. 51: e9. PMID 30912489 DOI: 10.1017/S0033583518000070 |
0.381 |
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| 2018 |
Jiang F, Liu JJ, Osuna BA, Xu M, Berry JD, Rauch BJ, Nogales E, Bondy-Denomy J, Doudna JA. Temperature-Responsive Competitive Inhibition of CRISPR-Cas9. Molecular Cell. PMID 30595438 DOI: 10.2210/Pdb6Mcc/Pdb |
0.651 |
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| 2018 |
Palermo G, Chen JS, Ricci CG, Rivalta I, Jinek M, Batista VS, Doudna JA, McCammon JA. Key role of the REC lobe during CRISPR-Cas9 activation by 'sensing', 'regulating', and 'locking' the catalytic HNH domain. Quarterly Reviews of Biophysics. 51. PMID 30555184 DOI: 10.1017/S0033583518000070 |
0.469 |
|
| 2018 |
Harrington LB, Burstein D, Chen JS, Paez-Espino D, Ma E, Witte IP, Cofsky JC, Kyrpides NC, Banfield JF, Doudna JA. Programmed DNA destruction by miniature CRISPR-Cas14 enzymes. Science (New York, N.Y.). PMID 30337455 DOI: 10.1126/Science.Aav4294 |
0.668 |
|
| 2018 |
Mancini A, Xavier-Magalhães A, Woods WS, Nguyen KT, Amen AM, Hayes JL, Fellmann C, Gapinske M, McKinney AM, Hong C, Jones LE, Walsh KM, Bell RJA, Doudna JA, Costa BM, et al. Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner. Cancer Cell. 34: 513-528.e8. PMID 30205050 DOI: 10.1016/J.Ccell.2018.08.003 |
0.371 |
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| 2018 |
Watters KE, Fellmann C, Bai HB, Ren SM, Doudna JA. Systematic discovery of natural CRISPR-Cas12a inhibitors. Science (New York, N.Y.). PMID 30190307 DOI: 10.1126/Science.Aau5138 |
0.454 |
|
| 2018 |
Knott GJ, Doudna JA. CRISPR-Cas guides the future of genetic engineering. Science (New York, N.Y.). 361: 866-869. PMID 30166482 DOI: 10.1126/Science.Aat5011 |
0.793 |
|
| 2018 |
Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, et al. The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders. Cell. 174: 505-520. PMID 30053424 DOI: 10.1016/J.Cell.2018.06.016 |
0.59 |
|
| 2018 |
Tambe A, East-Seletsky A, Knott GJ, Doudna JA, O'Connell MR. RNA Binding and HEPN-Nuclease Activation Are Decoupled in CRISPR-Cas13a. Cell Reports. 24: 1025-1036. PMID 30044970 DOI: 10.1016/J.Celrep.2018.06.105 |
0.847 |
|
| 2018 |
Huang CH, Lee KC, Doudna JA. Applications of CRISPR-Cas Enzymes in Cancer Therapeutics and Detection. Trends in Cancer. 4: 499-512. PMID 29937048 DOI: 10.1016/j.trecan.2018.05.006 |
0.274 |
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| 2018 |
Rouet R, Thuma BA, Roy MD, Lintner NG, Rubitski DM, Finley JE, Wisniewska HM, Mendonsa R, Hirsh A, de Oñate L, Compte J, Mclellan TJ, Bellenger J, Feng X, Varghese A, ... ... Doudna JA, et al. Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell Type Specific Gene Editing. Journal of the American Chemical Society. PMID 29668265 DOI: 10.1021/Jacs.8B01551 |
0.807 |
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| 2018 |
Lintner NG, McClure KF, Petersen D, Londregan AT, Piotrowski DW, Wei L, Xiao J, Bolt M, Loria PM, Maguire B, Geoghegan KF, Huang A, Rolph T, Liras S, Doudna JA, et al. Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. Plos Biology. 16: e1002628. PMID 29664898 DOI: 10.1371/journal.pbio.1002628 |
0.771 |
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| 2018 |
Lapinaite A, Doudna JA, Cate JHD. Programmable RNA recognition using a CRISPR-associated Argonaute. Proceedings of the National Academy of Sciences of the United States of America. PMID 29531059 DOI: 10.1073/Pnas.1717725115 |
0.851 |
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| 2018 |
Chen JS, Ma E, Harrington LB, Da Costa M, Tian X, Palefsky JM, Doudna JA. CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity. Science (New York, N.Y.). PMID 29449511 DOI: 10.1126/Science.Aar6245 |
0.539 |
|
| 2018 |
Kiessling LL, Doudna JA. Spotlight: A Conversation with Laura Kiessling and Jennifer Doudna. Acs Chemical Biology. 13: 290-295. PMID 29448761 DOI: 10.1021/Acschembio.8B00108 |
0.367 |
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| 2018 |
Strutt SC, Torrez RM, Kaya E, Negrete OA, Doudna JA. RNA-dependent RNA targeting by CRISPR-Cas9. Elife. 7. PMID 29303478 DOI: 10.7554/Elife.32724 |
0.61 |
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| 2018 |
Knight SC, Tjian R, Doudna JA. Genome im Fokus: Entwicklung und Anwendungen von CRISPR-Cas9-Bildgebungstechnologien Angewandte Chemie. 130: 4412-4420. DOI: 10.1002/Ange.201709201 |
0.381 |
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| 2017 |
Lee K, Conboy M, Park HM, Jiang F, Kim HJ, Dewitt MA, Mackley VA, Chang K, Rao A, Skinner C, Shobha T, Mehdipour M, Liu H, Huang WC, Lan F, ... ... Doudna JA, et al. Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA induces homology-directed DNA repair. Nature Biomedical Engineering. 1: 889-901. PMID 29805845 DOI: 10.1038/S41551-017-0137-2 |
0.442 |
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| 2017 |
Moreno-Mateos MA, Fernandez JP, Rouet R, Vejnar CE, Lane MA, Mis E, Khokha MK, Doudna JA, Giraldez AJ. CRISPR-Cpf1 mediates efficient homology-directed repair and temperature-controlled genome editing. Nature Communications. 8: 2024. PMID 29222508 DOI: 10.1038/S41467-017-01836-2 |
0.452 |
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| 2017 |
Blair JD, Hockemeyer D, Doudna JA, Bateup HS, Floor SN. Widespread Translational Remodeling during Human Neuronal Differentiation. Cell Reports. 21: 2005-2016. PMID 29141229 DOI: 10.1016/J.Celrep.2017.10.095 |
0.717 |
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| 2017 |
Harrington LB, Paez-Espino D, Staahl BT, Chen JS, Ma E, Kyrpides NC, Doudna JA. A thermostable Cas9 with increased lifetime in human plasma. Nature Communications. 8: 1424. PMID 29127284 DOI: 10.1038/S41467-017-01408-4 |
0.789 |
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| 2017 |
Knight S, Tjian R, Doudna J. GENOMES IN FOCUS: DEVELOPMENT AND APPLICATIONS OF CRISPR-CAS9 IMAGING TECHNOLOGIES. Angewandte Chemie (International Ed. in English). PMID 29080263 DOI: 10.1002/Anie.201709201 |
0.453 |
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| 2017 |
Chen JS, Dagdas YS, Kleinstiver BP, Welch MM, Sousa AA, Harrington LB, Sternberg SH, Joung JK, Yildiz A, Doudna JA. Enhanced proofreading governs CRISPR-Cas9 targeting accuracy. Nature. PMID 28931002 DOI: 10.1038/nature24268 |
0.738 |
|
| 2017 |
Knott GJ, East-Seletsky A, Cofsky JC, Holton JM, Charles E, O'Connell MR, Doudna JA. Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme. Nature Structural & Molecular Biology. PMID 28892041 DOI: 10.1038/Nsmb.3466 |
0.854 |
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| 2017 |
Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA. A Broad-Spectrum Inhibitor of CRISPR-Cas9. Cell. PMID 28844692 DOI: 10.1016/J.Cell.2017.07.037 |
0.817 |
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| 2017 |
Dagdas YS, Chen JS, Sternberg SH, Doudna JA, Yildiz A. A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9. Science Advances. 3: eaao0027. PMID 28808686 DOI: 10.1126/Sciadv.Aao0027 |
0.752 |
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| 2017 |
Wright AV, Liu JJ, Knott GJ, Doxzen KW, Nogales E, Doudna JA. Structures of the CRISPR genome integration complex. Science (New York, N.Y.). PMID 28729350 DOI: 10.1126/Science.Aao0679 |
0.817 |
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| 2017 |
Shin J, Jiang F, Liu JJ, Bray NL, Rauch BJ, Baik SH, Nogales E, Bondy-Denomy J, Corn JE, Doudna JA. Disabling Cas9 by an anti-CRISPR DNA mimic. Science Advances. 3: e1701620. PMID 28706995 DOI: 10.1126/Sciadv.1701620 |
0.656 |
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| 2017 |
Doxzen KW, Doudna JA. DNA recognition by an RNA-guided bacterial Argonaute. Plos One. 12: e0177097. PMID 28520746 DOI: 10.1371/Journal.Pone.0177097 |
0.615 |
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| 2017 |
Boyle EA, Andreasson JOL, Chircus LM, Sternberg SH, Wu MJ, Guegler CK, Doudna JA, Greenleaf WJ. High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding. Proceedings of the National Academy of Sciences of the United States of America. PMID 28495970 DOI: 10.1073/Pnas.1700557114 |
0.734 |
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| 2017 |
East-Seletsky A, O'Connell MR, Burstein D, Knott GJ, Doudna JA. RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes. Molecular Cell. 66: 373-383.e3. PMID 28475872 DOI: 10.1016/J.Molcel.2017.04.008 |
0.841 |
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| 2017 |
Liu TY, Iavarone AT, Doudna JA. Correction: RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System. Plos One. 12: e0175612. PMID 28384323 DOI: 10.1371/Journal.Pone.0175612 |
0.699 |
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| 2017 |
Jiang F, Doudna JA. CRISPR-Cas9 Structures and Mechanisms. Annual Review of Biophysics. PMID 28375731 DOI: 10.1146/Annurev-Biophys-062215-010822 |
0.6 |
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| 2017 |
Gaj T, Staahl BT, Rodrigues GM, Limsirichai P, Ekman FK, Doudna JA, Schaffer DV. Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery. Nucleic Acids Research. PMID 28334779 DOI: 10.1093/Nar/Gkx154 |
0.816 |
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| 2017 |
Lintner NG, McClure KF, Petersen D, Londregan AT, Piotrowski DW, Wei L, Xiao J, Bolt M, Loria PM, Maguire B, Geoghegan KF, Huang A, Rolph T, Liras S, Doudna JA, et al. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. Plos Biology. 15: e2001882. PMID 28323820 DOI: 10.1371/Journal.Pbio.2001882 |
0.779 |
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| 2017 |
Gorski SA, Vogel J, Doudna JA. RNA-based recognition and targeting: sowing the seeds of specificity. Nature Reviews. Molecular Cell Biology. PMID 28196981 DOI: 10.1038/nrm.2016.174 |
0.524 |
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| 2017 |
Staahl BT, Benekareddy M, Coulon-Bainier C, Banfal AA, Floor SN, Sabo JK, Urnes C, Munares GA, Ghosh A, Doudna JA. Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes. Nature Biotechnology. PMID 28191903 DOI: 10.1038/Nbt.3806 |
0.781 |
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| 2017 |
Liu TY, Iavarone AT, Doudna JA. RNA and DNA Targeting by a Reconstituted Thermus thermophiles Type III-A CRISPR-Cas System. Plos One. 12: e0170552. PMID 28114398 DOI: 10.1371/Journal.Pone.0170552 |
0.761 |
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| 2017 |
Knott GJ, East-Seletsky A, Cofsky JC, Holton JM, Charles E, Doudna JA. Guide bound structures of a divergent RNA-targeting A cleaving CRISPR-Cas13a enzyme Nature Structural & Molecular Biology. DOI: 10.2210/Pdb5W1I/Pdb |
0.757 |
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| 2017 |
Doudna J. CRISPR System: From Adaptive Immunity to Genome Editing Molecular Frontiers Journal. 1: 76-91. DOI: 10.1142/S2529732517400090 |
0.376 |
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| 2017 |
Chen JS, Doudna JA. The chemistry of Cas9 and its CRISPR colleagues Nature Reviews Chemistry. 1. DOI: 10.1038/s41570-017-0078 |
0.292 |
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| 2017 |
Doudna J. CRISPR book review — Doudna responds Nature. 547: 162-162. DOI: 10.1038/547162E |
0.317 |
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| 2017 |
Dagdas YS, Chen JS, Sternberg SH, Doudna JA, Yildiz A. Conformational Dynamics of Cas9 during DNA Binding Biophysical Journal. 112: 71a. DOI: 10.1016/J.Bpj.2016.11.429 |
0.768 |
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| 2016 |
Heler R, Wright AV, Vucelja M, Bikard D, Doudna JA, Marraffini LA. Mutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune Response. Molecular Cell. PMID 28017588 DOI: 10.1016/J.Molcel.2016.11.031 |
0.496 |
|
| 2016 |
Fellmann C, Gowen BG, Lin PC, Doudna JA, Corn JE. Cornerstones of CRISPR-Cas in drug discovery and therapy. Nature Reviews. Drug Discovery. PMID 28008168 DOI: 10.1038/Nrd.2016.238 |
0.407 |
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| 2016 |
Burstein D, Harrington LB, Strutt SC, Probst AJ, Anantharaman K, Thomas BC, Doudna JA, Banfield JF. New CRISPR-Cas systems from uncultivated microbes. Nature. PMID 28005056 DOI: 10.1038/Nature21059 |
0.611 |
|
| 2016 |
Koh HR, Kidwell MA, Doudna JA, Myong S. RNA scanning of a molecular machine with a built-in ruler. Journal of the American Chemical Society. PMID 27958730 DOI: 10.1021/Jacs.6B10387 |
0.829 |
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| 2016 |
Hultquist JF, Schumann K, Woo JM, Manganaro L, McGregor MJ, Doudna J, Simon V, Krogan NJ, Marson A. A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells. Cell Reports. 17: 1438-1452. PMID 27783955 DOI: 10.1016/J.Celrep.2016.09.080 |
0.377 |
|
| 2016 |
Chen X, Shen Y, Draper W, Buenrostro JD, Litzenburger U, Cho SW, Satpathy AT, Carter AC, Ghosh RP, East-Seletsky A, Doudna JA, Greenleaf WJ, Liphardt JT, Chang HY. ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing. Nature Methods. PMID 27749837 DOI: 10.1038/Nmeth.4031 |
0.412 |
|
| 2016 |
Schulze-Gahmen U, Echeverria I, Stjepanovic G, Bai Y, Lu H, Schneidman-Duhovny D, Doudna JA, Zhou Q, Sali A, Hurley JH. Insights into HIV-1 proviral transcription from the structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex. Elife. 5. PMID 27731797 DOI: 10.7554/Elife.15910 |
0.575 |
|
| 2016 |
East-Seletsky A, O'Connell MR, Knight SC, Burstein D, Cate JH, Tjian R, Doudna JA. Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection. Nature. PMID 27669025 DOI: 10.1038/Nature19802 |
0.855 |
|
| 2016 |
Singh D, Sternberg SH, Fei J, Doudna JA, Ha T. Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9. Nature Communications. 7: 12778. PMID 27624851 DOI: 10.1038/Ncomms12778 |
0.782 |
|
| 2016 |
Barrangou R, Doudna JA. Applications of CRISPR technologies in research and beyond. Nature Biotechnology. 34: 933-941. PMID 27606440 DOI: 10.1038/Nbt.3659 |
0.425 |
|
| 2016 |
Wright AV, Doudna JA. Protecting genome integrity during CRISPR immune adaptation. Nature Structural & Molecular Biology. PMID 27595346 DOI: 10.1038/Nsmb.3289 |
0.464 |
|
| 2016 |
Hochstrasser ML, Taylor DW, Kornfeld JE, Nogales E, Doudna JA. DNA Targeting by a Minimal CRISPR RNA-Guided Cascade. Molecular Cell. 63: 840-51. PMID 27588603 DOI: 10.1016/J.Molcel.2016.07.027 |
0.737 |
|
| 2016 |
Lee AS, Kranzusch PJ, Doudna JA, Cate JH. eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. Nature. 536: 96-9. PMID 27462815 DOI: 10.1038/Nature18954 |
0.824 |
|
| 2016 |
Carlson LA, Bai Y, Keane SC, Doudna JA, Hurley JH. Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies. Elife. 5. PMID 27343348 DOI: 10.7554/Elife.14663 |
0.619 |
|
| 2016 |
Nuñez JK, Bai L, Harrington LB, Hinder TL, Doudna JA. CRISPR Immunological Memory Requires a Host Factor for Specificity. Molecular Cell. 62: 824-33. PMID 27211867 DOI: 10.1016/J.Molcel.2016.04.027 |
0.807 |
|
| 2016 |
Oakes BL, Nadler DC, Flamholz A, Fellmann C, Staahl BT, Doudna JA, Savage DF. Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch. Nature Biotechnology. 34: 646-51. PMID 27136077 DOI: 10.1038/Nbt.3528 |
0.819 |
|
| 2016 |
Isaac RS, Jiang F, Doudna JA, Lim WA, Narlikar GJ, Almeida R. Nucleosome breathing and remodeling constrain CRISPR-Cas9 function. Elife. 5. PMID 27130520 DOI: 10.7554/Elife.13450 |
0.432 |
|
| 2016 |
Oh S, Flynn RA, Floor SN, Purzner J, Martin L, Do BT, Schubert S, Vaka D, Morrissy S, Li Y, Kool M, Hovestadt V, Jones DT, Northcott PA, Risch T, ... ... Doudna JA, et al. Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress. Oncotarget. 7: 28169-82. PMID 27058758 DOI: 10.18632/Oncotarget.8612 |
0.767 |
|
| 2016 |
Kaya E, Doxzen KW, Knoll KR, Wilson RC, Strutt SC, Kranzusch PJ, Doudna JA. A bacterial Argonaute with noncanonical guide RNA specificity. Proceedings of the National Academy of Sciences of the United States of America. 113: 4057-62. PMID 27035975 DOI: 10.1073/Pnas.1524385113 |
0.781 |
|
| 2016 |
Nelles DA, Fang MY, O'Connell MR, Xu JL, Markmiller SJ, Doudna JA, Yeo GW. Programmable RNA Tracking in Live Cells with CRISPR/Cas9. Cell. 165: 488-96. PMID 26997482 DOI: 10.1016/J.Cell.2016.02.054 |
0.794 |
|
| 2016 |
Amit I, Baker D, Barker R, Berger B, Bertozzi C, Bhatia S, Biffi A, Demichelis F, Doudna J, Dowdy SF, Endy D, Helmstaedter M, Junca H, June C, Kamb S, et al. Voices of biotech. Nature Biotechnology. 34: 270-275. PMID 26963549 DOI: 10.1038/Nbt.3502 |
0.469 |
|
| 2016 |
Nuñez JK, Harrington LB, Doudna JA. Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering. Acs Chemical Biology. 11: 681-8. PMID 26857072 DOI: 10.1021/Acschembio.5B01019 |
0.815 |
|
| 2016 |
Jiang F, Taylor DW, Chen JS, Kornfeld JE, Zhou K, Thompson AJ, Nogales E, Doudna JA. Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage. Science (New York, N.Y.). 351: 867-71. PMID 26841432 DOI: 10.1126/Science.Aad8282 |
0.703 |
|
| 2016 |
Wright AV, Nuñez JK, Doudna JA. Biology and Applications of CRISPR Systems: Harnessing Nature's Toolbox for Genome Engineering. Cell. 164: 29-44. PMID 26771484 DOI: 10.1016/J.Cell.2015.12.035 |
0.793 |
|
| 2016 |
Floor SN, Doudna JA. Tunable protein synthesis by transcript isoforms in human cells. Elife. 5. PMID 26735365 DOI: 10.7554/Elife.10921 |
0.743 |
|
| 2016 |
Floor SN, Barkovich KJ, Condon KJ, Shokat KM, Doudna JA. Analog sensitive chemical inhibition of the DEAD-box protein DDX3. Protein Science : a Publication of the Protein Society. 25: 638-49. PMID 26650549 DOI: 10.1002/Pro.2857 |
0.769 |
|
| 2016 |
Floor SN, Condon KJ, Sharma D, Jankowsky E, Doudna JA. Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3. The Journal of Biological Chemistry. 291: 2412-21. PMID 26598523 DOI: 10.1074/Jbc.M115.700625 |
0.771 |
|
| 2016 |
Schulze-Gahmen U, Echeverria I, Stjepanovic G, Bai Y, Lu H, Schneidman-Duhovny D, Doudna JA, Zhou Q, Sali A, Hurley JH. Author response: Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex Elife. DOI: 10.7554/Elife.15910.025 |
0.498 |
|
| 2016 |
Carlson L, Bai Y, Keane SC, Doudna JA, Hurley JH. Author response: Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies Elife. DOI: 10.7554/Elife.14663.015 |
0.563 |
|
| 2016 |
Isaac RS, Jiang F, Doudna JA, Lim WA, Narlikar GJ, Almeida R. Author response: Nucleosome breathing and remodeling constrain CRISPR-Cas9 function Elife. DOI: 10.7554/Elife.13450.049 |
0.337 |
|
| 2015 |
Doudna J. Genome-editing revolution: My whirlwind year with CRISPR Nature. 528: 469-471. PMID 26701037 DOI: 10.1038/528469A |
0.366 |
|
| 2015 |
Doudna JA, Gersbach CA. Genome editing: the end of the beginning. Genome Biology. 16: 292. PMID 26700220 DOI: 10.1186/S13059-015-0860-5 |
0.356 |
|
| 2015 |
Floor SN, Doudna JA. Get in LINE: Competition for Newly Minted Retrotransposon Proteins at the Ribosome. Molecular Cell. 60: 712-4. PMID 26638173 DOI: 10.1016/J.Molcel.2015.11.014 |
0.721 |
|
| 2015 |
Doudna J. Perspective: Embryo editing needs scrutiny Nature. 528: S6. PMID 26630598 DOI: 10.1038/528S6A |
0.388 |
|
| 2015 |
Knight SC, Xie L, Deng W, Guglielmi B, Witkowsky LB, Bosanac L, Zhang ET, El Beheiry M, Masson JB, Dahan M, Liu Z, Doudna JA, Tjian R. Dynamics of CRISPR-Cas9 genome interrogation in living cells. Science (New York, N.Y.). 350: 823-6. PMID 26564855 DOI: 10.1126/Science.Aac6572 |
0.567 |
|
| 2015 |
Ma E, Harrington LB, O'Connell MR, Zhou K, Doudna JA. Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes. Molecular Cell. 60: 398-407. PMID 26545076 DOI: 10.1016/J.Molcel.2015.10.030 |
0.784 |
|
| 2015 |
Sternberg SH, LaFrance B, Kaplan M, Doudna JA. Conformational control of DNA target cleavage by CRISPR-Cas9. Nature. 527: 110-3. PMID 26524520 DOI: 10.1038/Nature15544 |
0.824 |
|
| 2015 |
Redding S, Sternberg SH, Marshall M, Gibb B, Bhat P, Guegler CK, Wiedenheft B, Doudna JA, Greene EC. Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System. Cell. 163: 854-65. PMID 26522594 DOI: 10.1016/J.Cell.2015.10.003 |
0.824 |
|
| 2015 |
Nuñez JK, Harrington LB, Kranzusch PJ, Engelman AN, Doudna JA. Foreign DNA capture during CRISPR-Cas adaptive immunity. Nature. 527: 535-8. PMID 26503043 DOI: 10.1038/Nature15760 |
0.815 |
|
| 2015 |
Kranzusch PJ, Wilson SC, Lee AS, Berger JM, Doudna JA, Vance RE. Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling. Molecular Cell. 59: 891-903. PMID 26300263 DOI: 10.1016/J.Molcel.2015.07.022 |
0.751 |
|
| 2015 |
Schumann K, Lin S, Boyer E, Simeonov DR, Subramaniam M, Gate RE, Haliburton GE, Ye CJ, Bluestone JA, Doudna JA, Marson A. Generation of knock-in primary human T cells using Cas9 ribonucleoproteins. Proceedings of the National Academy of Sciences of the United States of America. 112: 10437-42. PMID 26216948 DOI: 10.1073/Pnas.1512503112 |
0.56 |
|
| 2015 |
Jiang F, Zhou K, Ma L, Gressel S, Doudna JA. STRUCTURAL BIOLOGY. A Cas9-guide RNA complex preorganized for target DNA recognition. Science (New York, N.Y.). 348: 1477-81. PMID 26113724 DOI: 10.1126/Science.Aab1452 |
0.602 |
|
| 2015 |
Sternberg SH, Doudna JA. Expanding the Biologist's Toolkit with CRISPR-Cas9. Molecular Cell. 58: 568-74. PMID 26000842 DOI: 10.1016/J.Molcel.2015.02.032 |
0.748 |
|
| 2015 |
Bosley KS, Botchan M, Bredenoord AL, Carroll D, Charo RA, Charpentier E, Cohen R, Corn J, Doudna J, Feng G, Greely HT, Isasi R, Ji W, Kim JS, Knoppers B, et al. CRISPR germline engineering--the community speaks. Nature Biotechnology. 33: 478-86. PMID 25965754 DOI: 10.1038/Nbt.3227 |
0.33 |
|
| 2015 |
Taylor DW, Zhu Y, Staals RH, Kornfeld JE, Shinkai A, van der Oost J, Nogales E, Doudna JA. Structural biology. Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning. Science (New York, N.Y.). 348: 581-5. PMID 25837515 DOI: 10.1126/Science.Aaa4535 |
0.742 |
|
| 2015 |
Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, et al. Biotechnology. A prudent path forward for genomic engineering and germline gene modification. Science (New York, N.Y.). 348: 36-8. PMID 25791083 DOI: 10.1126/Science.Aab1028 |
0.765 |
|
| 2015 |
Jiang F, Doudna JA. The structural biology of CRISPR-Cas systems. Current Opinion in Structural Biology. 30: 100-11. PMID 25723899 DOI: 10.1016/J.Sbi.2015.02.002 |
0.579 |
|
| 2015 |
Wright AV, Sternberg SH, Taylor DW, Staahl BT, Bardales JA, Kornfeld JE, Doudna JA. Rational design of a split-Cas9 enzyme complex. Proceedings of the National Academy of Sciences of the United States of America. 112: 2984-9. PMID 25713377 DOI: 10.1073/Pnas.1501698112 |
0.852 |
|
| 2015 |
Doudna JA. Genomic engineering and the future of medicine. Jama. 313: 791-2. PMID 25710652 DOI: 10.1001/Jama.2015.287 |
0.358 |
|
| 2015 |
Nuñez JK, Lee AS, Engelman A, Doudna JA. Integrase-mediated spacer acquisition during CRISPR-Cas adaptive immunity. Nature. 519: 193-8. PMID 25707795 DOI: 10.1038/Nature14237 |
0.809 |
|
| 2015 |
Wilson RC, Tambe A, Kidwell MA, Noland CL, Schneider CP, Doudna JA. Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesis. Molecular Cell. 57: 397-407. PMID 25557550 DOI: 10.1016/J.Molcel.2014.11.030 |
0.839 |
|
| 2015 |
Hochstrasser ML, Doudna JA. Cutting it close: CRISPR-associated endoribonuclease structure and function. Trends in Biochemical Sciences. 40: 58-66. PMID 25468820 DOI: 10.1016/J.Tibs.2014.10.007 |
0.6 |
|
| 2015 |
Floor SN, Doudna JA. Author response: Tunable protein synthesis by transcript isoforms in human cells Elife. DOI: 10.7554/Elife.10921.030 |
0.698 |
|
| 2015 |
Singh D, Sternberg SH, Fei J, Doudna JA, Ha T. Real-Time Observation of DNA Recognition by the RNA-Guided Endonuclease Cas9 using Single-Molecule FRET Biophysical Journal. 108: 26a. DOI: 10.1016/J.Bpj.2014.11.169 |
0.791 |
|
| 2014 |
Lin S, Staahl BT, Alla RK, Doudna JA. Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery. Elife. 3: e04766. PMID 25497837 DOI: 10.7554/Elife.04766 |
0.825 |
|
| 2014 |
Staals RH, Zhu Y, Taylor DW, Kornfeld JE, Sharma K, Barendregt A, Koehorst JJ, Vlot M, Neupane N, Varossieau K, Sakamoto K, Suzuki T, Dohmae N, Yokoyama S, Schaap PJ, ... ... Doudna JA, et al. RNA targeting by the type III-A CRISPR-Cas Csm complex of Thermus thermophilus. Molecular Cell. 56: 518-30. PMID 25457165 DOI: 10.1016/J.Molcel.2014.10.005 |
0.695 |
|
| 2014 |
Doudna JA, Charpentier E. Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Science (New York, N.Y.). 346: 1258096. PMID 25430774 DOI: 10.1126/Science.1258096 |
0.456 |
|
| 2014 |
Doudna JA, Sontheimer EJ. Methods in Enzymology. The use of CRISPR/Cas9, ZFNs, and TALENs in generating site-specific genome alterations. Preface. Methods in Enzymology. 546: xix-xx. PMID 25398356 DOI: 10.1016/B978-0-12-801185-0.09983-9 |
0.4 |
|
| 2014 |
Kapral GJ, Jain S, Noeske J, Doudna JA, Richardson DC, Richardson JS. New tools provide a second look at HDV ribozyme structure, dynamics and cleavage. Nucleic Acids Research. 42: 12833-46. PMID 25326328 DOI: 10.1093/Nar/Gku992 |
0.523 |
|
| 2014 |
O'Connell MR, Oakes BL, Sternberg SH, East-Seletsky A, Kaplan M, Doudna JA. Programmable RNA recognition and cleavage by CRISPR/Cas9. Nature. 516: 263-6. PMID 25274302 DOI: 10.1038/Nature13769 |
0.851 |
|
| 2014 |
Bai Y, Tambe A, Zhou K, Doudna JA. RNA-guided assembly of Rev-RRE nuclear export complexes. Elife. 3: e03656. PMID 25163983 DOI: 10.7554/Elife.03656 |
0.653 |
|
| 2014 |
Kidwell MA, Chan JM, Doudna JA. Evolutionarily conserved roles of the dicer helicase domain in regulating RNA interference processing. The Journal of Biological Chemistry. 289: 28352-62. PMID 25135636 DOI: 10.1074/Jbc.M114.589051 |
0.851 |
|
| 2014 |
Kranzusch PJ, Lee AS, Wilson SC, Solovykh MS, Vance RE, Berger JM, Doudna JA. Structure-guided reprogramming of human cGAS dinucleotide linkage specificity. Cell. 158: 1011-21. PMID 25131990 DOI: 10.1016/J.Cell.2014.07.028 |
0.765 |
|
| 2014 |
Mortimer SA, Kidwell MA, Doudna JA. Insights into RNA structure and function from genome-wide studies. Nature Reviews. Genetics. 15: 469-79. PMID 24821474 DOI: 10.1038/Nrg3681 |
0.848 |
|
| 2014 |
Nuñez JK, Kranzusch PJ, Noeske J, Wright AV, Davies CW, Doudna JA. Cas1-Cas2 complex formation mediates spacer acquisition during CRISPR-Cas adaptive immunity. Nature Structural & Molecular Biology. 21: 528-34. PMID 24793649 DOI: 10.1038/Nsmb.2820 |
0.81 |
|
| 2014 |
Hochstrasser ML, Taylor DW, Bhat P, Guegler CK, Sternberg SH, Nogales E, Doudna JA. CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference. Proceedings of the National Academy of Sciences of the United States of America. 111: 6618-23. PMID 24748111 DOI: 10.1073/Pnas.1405079111 |
0.827 |
|
| 2014 |
Jinek M, Jiang F, Taylor DW, Sternberg SH, Kaya E, Ma E, Anders C, Hauer M, Zhou K, Lin S, Kaplan M, Iavarone AT, Charpentier E, Nogales E, Doudna JA. Structures of Cas9 endonucleases reveal RNA-mediated conformational activation. Science (New York, N.Y.). 343: 1247997. PMID 24505130 DOI: 10.1126/Science.1247997 |
0.85 |
|
| 2014 |
Sternberg SH, Redding S, Jinek M, Greene EC, Doudna JA. DNA interrogation by the CRISPR RNA-guided endonuclease Cas9. Nature. 507: 62-7. PMID 24476820 DOI: 10.1038/Nature13011 |
0.793 |
|
| 2014 |
Niewoehner O, Jinek M, Doudna JA. Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases. Nucleic Acids Research. 42: 1341-53. PMID 24150936 DOI: 10.1093/Nar/Gkt922 |
0.617 |
|
| 2014 |
Lin S, Staahl BT, Alla RK, Doudna JA. Author response: Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery Elife. DOI: 10.7554/Elife.04766.010 |
0.525 |
|
| 2014 |
Bai Y, Tambe A, Zhou K, Doudna JA. Author response: RNA-guided assembly of Rev-RRE nuclear export complexes Elife. DOI: 10.7554/Elife.03656.018 |
0.614 |
|
| 2014 |
Nunez JK, Doudna JA. Structural Basis for Foreign DNA Integration in CRISPR Adaptive Immunity Biophysical Journal. 106: 695a-696a. DOI: 10.1016/J.Bpj.2013.11.3849 |
0.838 |
|
| 2014 |
Hochstrasser ML, Taylor DW, Bhat P, Guegler CK, Doudna JA. Target Recognition and Degradation by an Adaptive Bacterial Immune System Biophysical Journal. 106: 695a. DOI: 10.1016/J.Bpj.2013.11.3847 |
0.615 |
|
| 2014 |
Kidwell MA, Chan JM, Doudna JA. A Conserved Mechanism of RNA Substrate Recognition and Cleavage by Fungal Dicers Biophysical Journal. 106: 496a. DOI: 10.1016/J.Bpj.2013.11.2777 |
0.85 |
|
| 2014 |
Condon K, Floor S, Doudna J. Engineering Inhibitor Specificity in the Dead-Box Protein Family Biophysical Journal. 106: 495a-496a. DOI: 10.1016/J.Bpj.2013.11.2772 |
0.743 |
|
| 2014 |
Wilson RC, Doudna JA. The Dicer-TRBP Interface Structure and Implications for Strand Selection During Microrna Biogenesis Biophysical Journal. 106: 463a. DOI: 10.1016/J.Bpj.2013.11.2623 |
0.549 |
|
| 2014 |
Redding S, Sternberg SH, Bhat P, Guegler CK, Hochstrasser ML, Wiedenheft B, Doudna JA, Greene EC. Targeting and Degradation of Viral DNA by the CRISPR-Cas System of Escherichia Coli Biophysical Journal. 106: 430a. DOI: 10.1016/J.Bpj.2013.11.2421 |
0.822 |
|
| 2013 |
Staals RH, Agari Y, Maki-Yonekura S, Zhu Y, Taylor DW, van Duijn E, Barendregt A, Vlot M, Koehorst JJ, Sakamoto K, Masuda A, Dohmae N, Schaap PJ, Doudna JA, Heck AJ, et al. Structure and activity of the RNA-targeting Type III-B CRISPR-Cas complex of Thermus thermophilus. Molecular Cell. 52: 135-45. PMID 24119403 DOI: 10.1016/J.Molcel.2013.09.013 |
0.601 |
|
| 2013 |
Cox EM, Sagan SM, Mortimer SA, Doudna JA, Sarnow P. Enhancement of hepatitis C viral RNA abundance by precursor miR-122 molecules. Rna (New York, N.Y.). 19: 1825-32. PMID 24106328 DOI: 10.1261/Rna.040865.113 |
0.409 |
|
| 2013 |
Kidwell MA, Doudna JA. Activating silent argonautes. Nature Structural & Molecular Biology. 20: 769-71. PMID 23984440 DOI: 10.1038/Nsmb.2620 |
0.831 |
|
| 2013 |
Lo TW, Pickle CS, Lin S, Ralston EJ, Gurling M, Schartner CM, Bian Q, Doudna JA, Meyer BJ. Precise and heritable genome editing in evolutionarily diverse nematodes using TALENs and CRISPR/Cas9 to engineer insertions and deletions. Genetics. 195: 331-48. PMID 23934893 DOI: 10.1534/Genetics.113.155382 |
0.697 |
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| 2013 |
Pattanayak V, Lin S, Guilinger JP, Ma E, Doudna JA, Liu DR. High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity. Nature Biotechnology. 31: 839-43. PMID 23934178 DOI: 10.1038/Nbt.2673 |
0.699 |
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| 2013 |
Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, Stern-Ginossar N, Brandman O, Whitehead EH, Doudna JA, Lim WA, Weissman JS, Qi LS. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell. 154: 442-51. PMID 23849981 DOI: 10.1016/J.Cell.2013.06.044 |
0.689 |
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| 2013 |
Bai Y, Zhou K, Doudna JA. Hepatitis C virus 3'UTR regulates viral translation through direct interactions with the host translation machinery. Nucleic Acids Research. 41: 7861-74. PMID 23783572 DOI: 10.1093/Nar/Gkt543 |
0.557 |
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| 2013 |
Sun C, Querol-Audí J, Mortimer SA, Arias-Palomo E, Doudna JA, Nogales E, Cate JH. Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation. Nucleic Acids Research. 41: 7512-21. PMID 23766293 DOI: 10.1093/Nar/Gkt510 |
0.826 |
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| 2013 |
Kranzusch PJ, Lee AS, Berger JM, Doudna JA. Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity. Cell Reports. 3: 1362-8. PMID 23707061 DOI: 10.1016/J.Celrep.2013.05.008 |
0.765 |
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| 2013 |
Lee HY, Zhou K, Smith AM, Noland CL, Doudna JA. Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing. Nucleic Acids Research. 41: 6568-76. PMID 23661684 DOI: 10.1093/Nar/Gkt361 |
0.544 |
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| 2013 |
Wilson RC, Doudna JA. Molecular mechanisms of RNA interference. Annual Review of Biophysics. 42: 217-39. PMID 23654304 DOI: 10.1146/Annurev-Biophys-083012-130404 |
0.571 |
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| 2013 |
Taylor DW, Ma E, Shigematsu H, Cianfrocco MA, Noland CL, Nagayama K, Nogales E, Doudna JA, Wang HW. Substrate-specific structural rearrangements of human Dicer. Nature Structural & Molecular Biology. 20: 662-70. PMID 23624860 DOI: 10.1038/Nsmb.2564 |
0.767 |
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| 2013 |
Noland CL, Doudna JA. Multiple sensors ensure guide strand selection in human RNAi pathways. Rna (New York, N.Y.). 19: 639-48. PMID 23531496 DOI: 10.1261/Rna.037424.112 |
0.571 |
|
| 2013 |
Lee HY, Haurwitz RE, Apffel A, Zhou K, Smart B, Wenger CD, Laderman S, Bruhn L, Doudna JA. RNA-protein analysis using a conditional CRISPR nuclease. Proceedings of the National Academy of Sciences of the United States of America. 110: 5416-21. PMID 23493562 DOI: 10.1073/Pnas.1302807110 |
0.845 |
|
| 2013 |
Charpentier E, Doudna JA. Biotechnology: Rewriting a genome. Nature. 495: 50-1. PMID 23467164 DOI: 10.1038/495050A |
0.526 |
|
| 2013 |
Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell. 152: 1173-83. PMID 23452860 DOI: 10.1016/J.Cell.2013.02.022 |
0.675 |
|
| 2013 |
Mortimer SA, Doudna JA. Unconventional miR-122 binding stabilizes the HCV genome by forming a trimolecular RNA structure. Nucleic Acids Research. 41: 4230-40. PMID 23416544 DOI: 10.1093/Nar/Gkt075 |
0.408 |
|
| 2013 |
Jinek M, East A, Cheng A, Lin S, Ma E, Doudna J. RNA-programmed genome editing in human cells Elife. 2013. PMID 23386978 DOI: 10.7554/Elife.00471 |
0.691 |
|
| 2013 |
Koh HR, Kidwell MA, Ragunathan K, Doudna JA, Myong S. ATP-independent diffusion of double-stranded RNA binding proteins. Proceedings of the National Academy of Sciences of the United States of America. 110: 151-6. PMID 23251028 DOI: 10.1073/Pnas.1212917110 |
0.828 |
|
| 2013 |
Jinek M, East A, Cheng A, Lin S, Ma E, Doudna J. Author response: RNA-programmed genome editing in human cells Elife. DOI: 10.7554/Elife.00471.009 |
0.607 |
|
| 2013 |
Kidwell MA, Doudna JA. Erratum: Activating silent Argonautes Nature Structural & Molecular Biology. 20: 1236-1236. DOI: 10.1038/Nsmb1013-1236C |
0.77 |
|
| 2013 |
Sternberg SH, Redding S, Bhat P, Jinek M, Wiedenheft B, Doudna JA, Greene EC. Single-Molecule Observation of Viral DNA Targeting by CRISPR/Cas Immune Systems Biophysical Journal. 104: 198a. DOI: 10.1016/J.Bpj.2012.11.1120 |
0.823 |
|
| 2012 |
Lee HY, Doudna JA. TRBP alters human precursor microRNA processing in vitro. Rna (New York, N.Y.). 18: 2012-9. PMID 23006623 DOI: 10.1261/Rna.035501.112 |
0.444 |
|
| 2012 |
Qi L, Haurwitz RE, Shao W, Doudna JA, Arkin AP. RNA processing enables predictable programming of gene expression. Nature Biotechnology. 30: 1002-6. PMID 22983090 DOI: 10.1038/Nbt.2355 |
0.833 |
|
| 2012 |
van Duijn E, Barbu IM, Barendregt A, Jore MM, Wiedenheft B, Lundgren M, Westra ER, Brouns SJ, Doudna JA, van der Oost J, Heck AJ. Native tandem and ion mobility mass spectrometry highlight structural and modular similarities in clustered-regularly-interspaced shot-palindromic-repeats (CRISPR)-associated protein complexes from Escherichia coli and Pseudomonas aeruginosa. Molecular & Cellular Proteomics : McP. 11: 1430-41. PMID 22918228 DOI: 10.1074/Mcp.M112.020263 |
0.719 |
|
| 2012 |
Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna JA, Charpentier E. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science (New York, N.Y.). 337: 816-21. PMID 22745249 DOI: 10.1126/Science.1225829 |
0.62 |
|
| 2012 |
Ma E, Zhou K, Kidwell MA, Doudna JA. Coordinated activities of human dicer domains in regulatory RNA processing. Journal of Molecular Biology. 422: 466-76. PMID 22727743 DOI: 10.1016/J.Jmb.2012.06.009 |
0.845 |
|
| 2012 |
Kaya E, Doudna JA. Biochemistry. Guided tour to the heart of RISC. Science (New York, N.Y.). 336: 985-6. PMID 22628640 DOI: 10.1126/Science.1223549 |
0.559 |
|
| 2012 |
Haurwitz RE, Sternberg SH, Doudna JA. Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA. The Embo Journal. 31: 2824-32. PMID 22522703 DOI: 10.1038/Emboj.2012.107 |
0.847 |
|
| 2012 |
Sashital DG, Wiedenheft B, Doudna JA. Mechanism of foreign DNA selection in a bacterial adaptive immune system. Molecular Cell. 46: 606-15. PMID 22521690 DOI: 10.1016/J.Molcel.2012.03.020 |
0.826 |
|
| 2012 |
Sternberg SH, Haurwitz RE, Doudna JA. Mechanism of substrate selection by a highly specific CRISPR endoribonuclease. Rna (New York, N.Y.). 18: 661-72. PMID 22345129 DOI: 10.1261/Rna.030882.111 |
0.856 |
|
| 2012 |
Wiedenheft B, Sternberg SH, Doudna JA. RNA-guided genetic silencing systems in bacteria and archaea. Nature. 482: 331-8. PMID 22337052 DOI: 10.1038/Nature10886 |
0.836 |
|
| 2012 |
Mehle A, Dugan VG, Taubenberger JK, Doudna JA. Reassortment and mutation of the avian influenza virus polymerase PA subunit overcome species barriers. Journal of Virology. 86: 1750-7. PMID 22090127 DOI: 10.1128/Jvi.06203-11 |
0.688 |
|
| 2012 |
Ran Koh H, Anne Kidwell M, Ragunathan K, Doudna JA, Myong S. Trbp Sliding Promotes Dicer's Cleavage Activity Biophysical Journal. 102: 601a. DOI: 10.1016/J.Bpj.2011.11.3275 |
0.55 |
|
| 2011 |
Arribere JA, Doudna JA, Gilbert WV. Reconsidering movement of eukaryotic mRNAs between polysomes and P bodies. Molecular Cell. 44: 745-58. PMID 22152478 DOI: 10.1016/J.Molcel.2011.09.019 |
0.7 |
|
| 2011 |
Sun C, Todorovic A, Querol-Audí J, Bai Y, Villa N, Snyder M, Ashchyan J, Lewis CS, Hartland A, Gradia S, Fraser CS, Doudna JA, Nogales E, Cate JH. Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3). Proceedings of the National Academy of Sciences of the United States of America. 108: 20473-8. PMID 22135459 DOI: 10.1073/Pnas.1116821108 |
0.808 |
|
| 2011 |
Berry KE, Waghray S, Mortimer SA, Bai Y, Doudna JA. Crystal structure of the HCV IRES central domain reveals strategy for start-codon positioning. Structure (London, England : 1993). 19: 1456-66. PMID 22000514 DOI: 10.1016/J.Str.2011.08.002 |
0.678 |
|
| 2011 |
Wiedenheft B, Lander GC, Zhou K, Jore MM, Brouns SJ, van der Oost J, Doudna JA, Nogales E. Structures of the RNA-guided surveillance complex from a bacterial immune system. Nature. 477: 486-9. PMID 21938068 DOI: 10.1038/Nature10402 |
0.791 |
|
| 2011 |
Noland CL, Ma E, Doudna JA. siRNA repositioning for guide strand selection by human Dicer complexes. Molecular Cell. 43: 110-21. PMID 21726814 DOI: 10.1016/J.Molcel.2011.05.028 |
0.578 |
|
| 2011 |
Aviran S, Trapnell C, Lucks JB, Mortimer SA, Luo S, Schroth GP, Doudna JA, Arkin AP, Pachter L. Modeling and automation of sequencing-based characterization of RNA structure. Proceedings of the National Academy of Sciences of the United States of America. 108: 11069-74. PMID 21642536 DOI: 10.1073/Pnas.1106541108 |
0.529 |
|
| 2011 |
Lucks JB, Mortimer SA, Trapnell C, Luo S, Aviran S, Schroth GP, Pachter L, Doudna JA, Arkin AP. Multiplexed RNA structure characterization with selective 2'-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq). Proceedings of the National Academy of Sciences of the United States of America. 108: 11063-8. PMID 21642531 DOI: 10.1073/Pnas.1106501108 |
0.571 |
|
| 2011 |
Sashital DG, Jinek M, Doudna JA. An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3. Nature Structural & Molecular Biology. 18: 680-7. PMID 21572442 DOI: 10.1038/Nsmb.2043 |
0.806 |
|
| 2011 |
Wiedenheft B, van Duijn E, Bultema JB, Bultema J, Waghmare SP, Waghmare S, Zhou K, Barendregt A, Westphal W, Heck AJ, Heck A, Boekema EJ, Boekema E, Dickman MJ, Dickman M, ... Doudna JA, et al. RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions. Proceedings of the National Academy of Sciences of the United States of America. 108: 10092-7. PMID 21536913 DOI: 10.1073/Pnas.1102716108 |
0.743 |
|
| 2011 |
Jore MM, Lundgren M, van Duijn E, Bultema JB, Westra ER, Waghmare SP, Wiedenheft B, Pul U, Wurm R, Wagner R, Beijer MR, Barendregt A, Zhou K, Snijders AP, Dickman MJ, ... Doudna JA, et al. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nature Structural & Molecular Biology. 18: 529-36. PMID 21460843 DOI: 10.1038/Nsmb.2019 |
0.75 |
|
| 2011 |
Jinek M, Coyle SM, Doudna JA. Coupled 5' nucleotide recognition and processivity in Xrn1-mediated mRNA decay. Molecular Cell. 41: 600-8. PMID 21362555 DOI: 10.1016/J.Molcel.2011.02.004 |
0.55 |
|
| 2011 |
Ataide SF, Schmitz N, Shen K, Ke A, Shan SO, Doudna JA, Ban N. The crystal structure of the signal recognition particle in complex with its receptor. Science (New York, N.Y.). 331: 881-6. PMID 21330537 DOI: 10.1126/Science.1196473 |
0.831 |
|
| 2011 |
Berry KE, Peng B, Koditek D, Beeman D, Pagratis N, Perry JK, Parrish J, Zhong W, Doudna JA, Shih IH. Optimized high-throughput screen for hepatitis C virus translation inhibitors. Journal of Biomolecular Screening. 16: 211-20. PMID 21297107 DOI: 10.1177/1087057110391665 |
0.585 |
|
| 2011 |
Wiedenheft B, Van Duijn E, Bultema J, Waghmare S, Zhou K, Barendregt A, Westphal W, Heck AJR, Boekema EJ, Dickman MJ, Doudna JA. RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 25 (10092-10097) DOI: 10.1073/pnas.1102716108) Proceedings of the National Academy of Sciences of the United States of America. 108: 15010. DOI: 10.1073/pnas.1111854108 |
0.406 |
|
| 2010 |
Mehle A, Doudna JA. A host of factors regulating influenza virus replication. Viruses. 2: 566-73. PMID 21994648 DOI: 10.3390/V2020566 |
0.662 |
|
| 2010 |
Chakravarthy S, Sternberg SH, Kellenberger CA, Doudna JA. Substrate-specific kinetics of Dicer-catalyzed RNA processing. Journal of Molecular Biology. 404: 392-402. PMID 20932845 DOI: 10.1016/J.Jmb.2010.09.030 |
0.815 |
|
| 2010 |
Weeks AM, Coyle SM, Jinek M, Doudna JA, Chang MC. Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity. Biochemistry. 49: 9269-79. PMID 20836570 DOI: 10.1021/Bi101102U |
0.711 |
|
| 2010 |
Haurwitz RE, Jinek M, Wiedenheft B, Zhou K, Doudna JA. Sequence- and structure-specific RNA processing by a CRISPR endonuclease. Science (New York, N.Y.). 329: 1355-8. PMID 20829488 DOI: 10.1126/Science.1192272 |
0.847 |
|
| 2010 |
Berry KE, Waghray S, Doudna JA. The HCV IRES pseudoknot positions the initiation codon on the 40S ribosomal subunit. Rna (New York, N.Y.). 16: 1559-69. PMID 20584896 DOI: 10.1261/Rna.2197210 |
0.643 |
|
| 2010 |
Clarkson BK, Gilbert WV, Doudna JA. Functional overlap between eIF4G isoforms in Saccharomyces cerevisiae. Plos One. 5: e9114. PMID 20161741 DOI: 10.1371/Journal.Pone.0009114 |
0.786 |
|
| 2010 |
Jinek M, Fabian MR, Coyle SM, Sonenberg N, Doudna JA. Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation. Nature Structural & Molecular Biology. 17: 238-40. PMID 20098421 DOI: 10.1038/Nsmb.1768 |
0.444 |
|
| 2010 |
Sashital DG, Doudna JA. Structural insights into RNA interference. Current Opinion in Structural Biology. 20: 90-7. PMID 20053548 DOI: 10.1016/J.Sbi.2009.12.001 |
0.787 |
|
| 2009 |
Mehle A, Doudna JA. Adaptive strategies of the influenza virus polymerase for replication in humans. Proceedings of the National Academy of Sciences of the United States of America. 106: 21312-6. PMID 19995968 DOI: 10.1073/Pnas.0911915106 |
0.684 |
|
| 2009 |
Wang HW, Noland C, Siridechadilok B, Taylor DW, Ma E, Felderer K, Doudna JA, Nogales E. Structural insights into RNA processing by the human RISC-loading complex. Nature Structural & Molecular Biology. 16: 1148-53. PMID 19820710 DOI: 10.1038/Nsmb.1673 |
0.842 |
|
| 2009 |
Fabian MR, Mathonnet G, Sundermeier T, Mathys H, Zipprich JT, Svitkin YV, Rivas F, Jinek M, Wohlschlegel J, Doudna JA, Chen CY, Shyu AB, Yates JR, Hannon GJ, Filipowicz W, et al. Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Molecular Cell. 35: 868-80. PMID 19716330 DOI: 10.1016/J.Molcel.2009.08.004 |
0.368 |
|
| 2009 |
Wiedenheft B, Zhou K, Jinek M, Coyle SM, Ma W, Doudna JA. Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated genome defense. Structure (London, England : 1993). 17: 904-12. PMID 19523907 DOI: 10.1016/J.Str.2009.03.019 |
0.689 |
|
| 2009 |
Fraser CS, Hershey JW, Doudna JA. The pathway of hepatitis C virus mRNA recruitment to the human ribosome. Nature Structural & Molecular Biology. 16: 397-404. PMID 19287397 DOI: 10.1038/Nsmb.1572 |
0.698 |
|
| 2009 |
Fukunaga R, Doudna JA. dsRNA with 5' overhangs contributes to endogenous and antiviral RNA silencing pathways in plants. The Embo Journal. 28: 545-55. PMID 19165150 DOI: 10.1038/Emboj.2009.2 |
0.778 |
|
| 2009 |
Jinek M, Doudna JA. A three-dimensional view of the molecular machinery of RNA interference. Nature. 457: 405-12. PMID 19158786 DOI: 10.1038/Nature07755 |
0.588 |
|
| 2009 |
Coyle SM, Gilbert WV, Doudna JA. Direct link between RACK1 function and localization at the ribosome in vivo. Molecular and Cellular Biology. 29: 1626-34. PMID 19114558 DOI: 10.1128/Mcb.01718-08 |
0.732 |
|
| 2008 |
Mehle A, Doudna JA. An inhibitory activity in human cells restricts the function of an avian-like influenza virus polymerase. Cell Host & Microbe. 4: 111-22. PMID 18692771 DOI: 10.1016/J.Chom.2008.06.007 |
0.685 |
|
| 2008 |
Zhou M, Sandercock AM, Fraser CS, Ridlova G, Stephens E, Schenauer MR, Yokoi-Fong T, Barsky D, Leary JA, Hershey JW, Doudna JA, Robinson CV. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. Proceedings of the National Academy of Sciences of the United States of America. 105: 18139-44. PMID 18599441 DOI: 10.1073/Pnas.0801313105 |
0.69 |
|
| 2008 |
Puglisi JD, Doudna JA. Nucleic acids and their protein partners. Current Opinion in Structural Biology. 18: 279-81. PMID 18547801 DOI: 10.1016/J.Sbi.2008.05.004 |
0.356 |
|
| 2008 |
Ma E, MacRae IJ, Kirsch JF, Doudna JA. Autoinhibition of human dicer by its internal helicase domain. Journal of Molecular Biology. 380: 237-43. PMID 18508075 DOI: 10.1016/J.Jmb.2008.05.005 |
0.741 |
|
| 2008 |
MacRae IJ, Ma E, Zhou M, Robinson CV, Doudna JA. In vitro reconstitution of the human RISC-loading complex. Proceedings of the National Academy of Sciences of the United States of America. 105: 512-7. PMID 18178619 DOI: 10.1073/Pnas.0710869105 |
0.676 |
|
| 2007 |
Fraser CS, Doudna JA. Quantitative studies of ribosome conformational dynamics. Quarterly Reviews of Biophysics. 40: 163-89. PMID 18072984 DOI: 10.1017/S0033583507004647 |
0.678 |
|
| 2007 |
MacRae IJ, Zhou K, Doudna JA. Structural determinants of RNA recognition and cleavage by Dicer. Nature Structural & Molecular Biology. 14: 934-40. PMID 17873886 DOI: 10.1038/Nsmb1293 |
0.772 |
|
| 2007 |
Gilbert WV, Zhou K, Butler TK, Doudna JA. Cap-independent translation is required for starvation-induced differentiation in yeast. Science (New York, N.Y.). 317: 1224-7. PMID 17761883 DOI: 10.1126/Science.1144467 |
0.74 |
|
| 2007 |
MacRae IJ, Doudna JA. An unusual case of pseudo-merohedral twinning in orthorhombic crystals of Dicer. Acta Crystallographica. Section D, Biological Crystallography. 63: 993-9. PMID 17704568 DOI: 10.1107/S0907444907036128 |
0.631 |
|
| 2007 |
Fraser CS, Berry KE, Hershey JW, Doudna JA. eIF3j is located in the decoding center of the human 40S ribosomal subunit. Molecular Cell. 26: 811-9. PMID 17588516 DOI: 10.1016/J.Molcel.2007.05.019 |
0.766 |
|
| 2007 |
Kiessling LL, Doudna JA, Johnsson K, Mapp AK, Marletta MA, Seeberger PH, Williamson JR, Wedde SG. A higher degree of difficulty. Acs Chemical Biology. 2: 197-9. PMID 17455890 DOI: 10.1021/Cb7000846 |
0.638 |
|
| 2007 |
Ke A, Ding F, Batchelor JD, Doudna JA. Structural roles of monovalent cations in the HDV ribozyme. Structure (London, England : 1993). 15: 281-7. PMID 17355864 DOI: 10.1016/J.Str.2007.01.017 |
0.646 |
|
| 2007 |
Damoc E, Fraser CS, Zhou M, Videler H, Mayeur GL, Hershey JW, Doudna JA, Robinson CV, Leary JA. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. Molecular & Cellular Proteomics : McP. 6: 1135-46. PMID 17322308 DOI: 10.1074/Mcp.M600399-Mcp200 |
0.682 |
|
| 2007 |
MacRae IJ, Doudna JA. Ribonuclease revisited: structural insights into ribonuclease III family enzymes. Current Opinion in Structural Biology. 17: 138-45. PMID 17194582 DOI: 10.1016/J.Sbi.2006.12.002 |
0.745 |
|
| 2007 |
Siu FY, Spanggord RJ, Doudna JA. SRP RNA provides the physiologically essential GTPase activation function in cotranslational protein targeting. Rna (New York, N.Y.). 13: 240-50. PMID 17164479 DOI: 10.1261/Rna.135407 |
0.832 |
|
| 2007 |
Fraser CS, Doudna JA. Structural and mechanistic insights into hepatitis C viral translation initiation. Nature Reviews. Microbiology. 5: 29-38. PMID 17128284 DOI: 10.1038/Nrmicro1558 |
0.692 |
|
| 2007 |
Wu S, Ke A, Doudna JA. A fast and efficient procedure to produce scFvs specific for large macromolecular complexes. Journal of Immunological Methods. 318: 95-101. PMID 17126854 DOI: 10.1016/J.Jim.2006.10.005 |
0.555 |
|
| 2007 |
Doudna JA, Sarnow P. 5 Translation Initiation by Viral Internal Ribosome Entry Sites Cold Spring Harbor Monograph Archive. 48: 129-153. DOI: 10.1101/087969767.48.129 |
0.448 |
|
| 2007 |
Doudna JA. The right chemistry: An updated nucleic acids textbook Acs Chemical Biology. 2: 211-212. DOI: 10.1021/Cb700048G |
0.326 |
|
| 2006 |
Macrae IJ, Li F, Zhou K, Cande WZ, Doudna JA. Structure of Dicer and mechanistic implications for RNAi. Cold Spring Harbor Symposia On Quantitative Biology. 71: 73-80. PMID 17381283 DOI: 10.1101/Sqb.2006.71.042 |
0.756 |
|
| 2006 |
Green R, Doudna JA. RNAs regulate biology. Acs Chemical Biology. 1: 335-8. PMID 17163766 DOI: 10.1021/Cb600277M |
0.654 |
|
| 2006 |
Chmiel NH, Rio DC, Doudna JA. Distinct contributions of KH domains to substrate binding affinity of Drosophila P-element somatic inhibitor protein. Rna (New York, N.Y.). 12: 283-91. PMID 16428607 DOI: 10.1261/Rna.2175706 |
0.527 |
|
| 2006 |
Macrae IJ, Zhou K, Li F, Repic A, Brooks AN, Cande WZ, Adams PD, Doudna JA. Structural basis for double-stranded RNA processing by Dicer. Science (New York, N.Y.). 311: 195-8. PMID 16410517 DOI: 10.1126/Science.1121638 |
0.76 |
|
| 2006 |
Karbstein K, Doudna JA. GTP-dependent formation of a ribonucleoprotein subcomplex required for ribosome biogenesis. Journal of Molecular Biology. 356: 432-43. PMID 16376378 DOI: 10.1016/J.Jmb.2005.11.052 |
0.765 |
|
| 2005 |
Aggarwal AK, Doudna JA. Protein-nucleic acid interactions: unlocking mysteries old and new. Current Opinion in Structural Biology. 15: 65-67. PMID 34650322 DOI: 10.1016/j.sbi.2005.01.017 |
0.247 |
|
| 2005 |
Doudna JA. Chemical biology at the crossroads of molecular structure and mechanism. Nature Chemical Biology. 1: 300-3. PMID 16408062 DOI: 10.1038/Nchembio1105-300 |
0.386 |
|
| 2005 |
Siridechadilok B, Fraser CS, Hall RJ, Doudna JA, Nogales E. Structural roles for human translation factor eIF3 in initiation of protein synthesis. Science (New York, N.Y.). 310: 1513-5. PMID 16322461 DOI: 10.1126/Science.1118977 |
0.821 |
|
| 2005 |
Karbstein K, Jonas S, Doudna JA. An essential GTPase promotes assembly of preribosomal RNA processing complexes. Molecular Cell. 20: 633-43. PMID 16307926 DOI: 10.1016/J.Molcel.2005.09.017 |
0.776 |
|
| 2005 |
Spanggord RJ, Siu F, Ke A, Doudna JA. RNA-mediated interaction between the peptide-binding and GTPase domains of the signal recognition particle. Nature Structural & Molecular Biology. 12: 1116-22. PMID 16299512 DOI: 10.1038/Nsmb1025 |
0.816 |
|
| 2005 |
Chen L, Lullo DJ, Ma E, Celniker SE, Rio DC, Doudna JA. Identification and analysis of U5 snRNA variants in Drosophila. Rna (New York, N.Y.). 11: 1473-7. PMID 16199758 DOI: 10.1261/Rna.2141505 |
0.527 |
|
| 2005 |
Macrae IJ, Doudna JA. Ro's role in RNA reconnaissance. Cell. 121: 495-6. PMID 15907458 DOI: 10.1016/J.Cell.2005.05.004 |
0.756 |
|
| 2005 |
Yu Y, Ji H, Doudna JA, Leary JA. Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes. Protein Science : a Publication of the Protein Society. 14: 1438-46. PMID 15883184 DOI: 10.1110/Ps.041293005 |
0.45 |
|
| 2005 |
Doudna JA, Lorsch JR. Ribozyme catalysis: not different, just worse. Nature Structural & Molecular Biology. 12: 395-402. PMID 15870731 DOI: 10.1038/Nsmb932 |
0.714 |
|
| 2005 |
Jazayeri P, Schellenberg A, Rosehart W, Doudna J, Widergren S, Lawrence D, Mickey J, Jones S. A Survey of Load Control Programs for Price and System Stability Ieee Transactions On Power Systems. 20: 1504-1509. DOI: 10.1109/TPWRS.2005.852147 |
0.188 |
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| 2005 |
Doudna JA, MacRae IJ, Zhou K. Structural basis for RNA-regulated gene expression Acta Crystallographica Section a Foundations of Crystallography. 61: c59-c59. DOI: 10.1107/S0108767305097485 |
0.697 |
|
| 2005 |
Aggarwal AK, Doudna JA. Protein-nucleic acid interactions: Unlocking mysteries old and new Current Opinion in Structural Biology. 15: 65-67. DOI: 10.1016/J.Sbi.2005.01.017 |
0.354 |
|
| 2004 |
Ji H, Fraser CS, Yu Y, Leary J, Doudna JA. Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA. Proceedings of the National Academy of Sciences of the United States of America. 101: 16990-5. PMID 15563596 DOI: 10.1073/Pnas.0407402101 |
0.747 |
|
| 2004 |
Ke A, Doudna JA. Crystallization of RNA and RNA-protein complexes. Methods (San Diego, Calif.). 34: 408-14. PMID 15325657 DOI: 10.1016/J.Ymeth.2004.03.027 |
0.722 |
|
| 2004 |
Doudna JA, Batey RT. Structural insights into the signal recognition particle. Annual Review of Biochemistry. 73: 539-57. PMID 15189152 DOI: 10.1146/Annurev.Biochem.73.011303.074048 |
0.642 |
|
| 2004 |
Rambo RP, Doudna JA. Assembly of an active group II intron-maturase complex by protein dimerization. Biochemistry. 43: 6486-97. PMID 15157082 DOI: 10.1021/Bi049912U |
0.774 |
|
| 2004 |
Ke A, Zhou K, Ding F, Cate JH, Doudna JA. A conformational switch controls hepatitis delta virus ribozyme catalysis. Nature. 429: 201-5. PMID 15141216 DOI: 10.1038/Nature02522 |
0.833 |
|
| 2004 |
Karbstein K, Doudna JA. RNA: primed for packing? Chemistry & Biology. 11: 149-51. PMID 15123272 DOI: 10.1016/J.Chembiol.2004.02.007 |
0.768 |
|
| 2004 |
Lupták A, Doudna JA. Distinct sites of phosphorothioate substitution interfere with folding and splicing of the Anabaena group I intron. Nucleic Acids Research. 32: 2272-80. PMID 15107495 DOI: 10.1093/Nar/Gkh548 |
0.84 |
|
| 2004 |
Sagar MB, Lucast L, Doudna JA. Conserved but nonessential interaction of SRP RNA with translation factor EF-G. Rna (New York, N.Y.). 10: 772-8. PMID 15100432 DOI: 10.1261/Rna.5266504 |
0.56 |
|
| 2004 |
Fraser CS, Lee JY, Mayeur GL, Bushell M, Doudna JA, Hershey JW. The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro. The Journal of Biological Chemistry. 279: 8946-56. PMID 14688252 DOI: 10.1074/Jbc.M312745200 |
0.652 |
|
| 2003 |
Aggarwal AK, Doudna JA. Protein-nucleic acid interactions. Current Opinion in Structural Biology. 13: 3-5. PMID 34276144 DOI: 10.1016/s0959-440x(03)00004-6 |
0.254 |
|
| 2002 |
Batey RT, Doudna JA. Structural and energetic analysis of metal ions essential to SRP signal recognition domain assembly. Biochemistry. 41: 11703-10. PMID 12269812 DOI: 10.1021/Bi026163C |
0.664 |
|
| 2002 |
Battle DJ, Doudna JA. Specificity of RNA-RNA helix recognition. Proceedings of the National Academy of Sciences of the United States of America. 99: 11676-81. PMID 12189204 DOI: 10.1073/Pnas.182221799 |
0.846 |
|
| 2002 |
Doudna JA, Cech TR. The chemical repertoire of natural ribozymes. Nature. 418: 222-8. PMID 12110898 DOI: 10.1038/418222A |
0.661 |
|
| 2002 |
Doudna JA, Rath VL. Structure and function of the eukaryotic ribosome: the next frontier. Cell. 109: 153-6. PMID 12007402 DOI: 10.1016/S0092-8674(02)00725-0 |
0.444 |
|
| 2002 |
Kieft JS, Zhou K, Grech A, Jubin R, Doudna JA. Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation. Nature Structural Biology. 9: 370-4. PMID 11927953 DOI: 10.1038/Nsb781 |
0.829 |
|
| 2002 |
Zhang L, Doudna JA. Structural insights into group II intron catalysis and branch-site selection. Science (New York, N.Y.). 295: 2084-8. PMID 11859154 DOI: 10.1126/Science.1069268 |
0.608 |
|
| 2001 |
Ferré-D'Amaré AR, Doudna JA. Methods to crystallize RNA. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 7.6. PMID 18428874 DOI: 10.1002/0471142700.Nc0706S00 |
0.698 |
|
| 2001 |
Kieft JS, Grech A, Adams P, Doudna JA. Mechanisms of internal ribosome entry in translation initiation Cold Spring Harbor Symposia On Quantitative Biology. 66: 277-283. PMID 12762029 DOI: 10.1101/Sqb.2001.66.277 |
0.639 |
|
| 2001 |
Murray JM, Doudna JA. Creative catalysis: Pieces of the RNA world jigsaw Trends in Biochemical Sciences. 26: 699-701. PMID 11738588 DOI: 10.1016/S0968-0004(01)02019-9 |
0.51 |
|
| 2001 |
Lupták A, Ferré-D'Amaré AR, Zhou K, Zilm KW, Doudna JA. Direct pK(a) measurement of the active-site cytosine in a genomic hepatitis delta virus ribozyme. Journal of the American Chemical Society. 123: 8447-52. PMID 11525650 DOI: 10.1021/Ja016091X |
0.789 |
|
| 2001 |
Doherty EA, Doudna JA. Ribozyme structures and mechanisms. Annual Review of Biophysics and Biomolecular Structure. 30: 457-75. PMID 11441810 DOI: 10.1146/Annurev.Biophys.30.1.457 |
0.84 |
|
| 2001 |
Doherty EA, Batey RT, Masquida B, Doudna JA. A universal mode of helix packing in RNA. Nature Structural Biology. 8: 339-43. PMID 11276255 DOI: 10.1038/86221 |
0.844 |
|
| 2001 |
Lucast LJ, Batey RT, Doudna JA. Large-scale purification of a stable form of recombinant tobacco etch virus protease. Biotechniques. 30: 544-6, 548, 550 pass. PMID 11252791 DOI: 10.2144/01303St06 |
0.61 |
|
| 2001 |
Batey RT, Sagar MB, Doudna JA. Structural and energetic analysis of RNA recognition by a universally conserved protein from the signal recognition particle. Journal of Molecular Biology. 307: 229-46. PMID 11243816 DOI: 10.1006/Jmbi.2000.4454 |
0.706 |
|
| 2001 |
Spahn CM, Kieft JS, Grassucci RA, Penczek PA, Zhou K, Doudna JA, Frank J. Hepatitis C virus IRES RNA-induced changes in the conformation of the 40s ribosomal subunit. Science (New York, N.Y.). 291: 1959-62. PMID 11239155 DOI: 10.1126/Science.1058409 |
0.722 |
|
| 2001 |
Kieft JS, Zhou K, Jubin R, Doudna JA. Mechanism of ribosome recruitment by hepatitis C IRES RNA. Rna (New York, N.Y.). 7: 194-206. PMID 11233977 DOI: 10.1017/S1355838201001790 |
0.745 |
|
| 2001 |
Battle DJ, Doudna JA. The stem-loop binding protein forms a highly stable and specific complex with the 3' stem-loop of histone mRNAs. Rna (New York, N.Y.). 7: 123-32. PMID 11214174 DOI: 10.1017/S1355838201001820 |
0.813 |
|
| 2001 |
Doudna JA, Richmond TJ. Editorial OverviewProtein–nucleic acid interactions Current Opinion in Structural Biology. 11. DOI: 10.1016/S0959-440X(00)00178-0 |
0.316 |
|
| 2001 |
Doudna JA. 3 – RNA Structures Determined by X-ray Crystallography Rna. 49-60. DOI: 10.1016/B978-008043408-7/50024-1 |
0.469 |
|
| 2000 |
Doudna JA. Structural genomics of RNA. Nature Structural Biology. 7: 954-6. PMID 11103998 DOI: 10.1038/80729 |
0.584 |
|
| 2000 |
Hanna RL, Gryaznov SM, Doudna JA. A phosphoramidate substrate analog is a competitive inhibitor of the Tetrahymena group I ribozyme. Chemistry & Biology. 7: 845-54. PMID 11094338 DOI: 10.1016/S1074-5521(00)00033-8 |
0.823 |
|
| 2000 |
Jubin R, Vantuno NE, Kieft JS, Murray MG, Doudna JA, Lau JY, Baroudy BM. Hepatitis C virus internal ribosome entry site (IRES) stem loop IIId contains a phylogenetically conserved GGG triplet essential for translation and IRES folding. Journal of Virology. 74: 10430-7. PMID 11044087 DOI: 10.1128/Jvi.74.22.10430-10437.2000 |
0.68 |
|
| 2000 |
Doherty EA, Doudna JA. Ribozyme structures and mechanisms. Annual Review of Biochemistry. 69: 597-615. PMID 10966470 DOI: 10.1146/Annurev.Biochem.69.1.597 |
0.84 |
|
| 2000 |
Cate JH, Doudna JA. Solving large RNA structures by X-ray crystallography Methods in Enzymology. 317: 169-180. PMID 10829280 DOI: 10.1016/S0076-6879(00)17014-4 |
0.774 |
|
| 2000 |
Jeruzalmi D, Kuriyan J, Doudna J. Paul Sigler (1934-2000). Trends in Biochemical Sciences. 25: 221-2. PMID 10782089 DOI: 10.1016/S0968-0004(00)01587-5 |
0.289 |
|
| 2000 |
Hanna R, Doudna JA. Metal ions in ribozyme folding and catalysis Current Opinion in Chemical Biology. 4: 166-170. PMID 10742186 DOI: 10.1016/S1367-5931(99)00071-X |
0.747 |
|
| 2000 |
Engelhardt MA, Doherty EA, Knitt DS, Doudna JA, Herschlag D. The P5abc peripheral element facilitates preorganization of the tetrahymena group I ribozyme for catalysis. Biochemistry. 39: 2639-51. PMID 10704214 DOI: 10.1021/Bi992313G |
0.8 |
|
| 2000 |
Batey RT, Rambo RP, Lucast L, Rha B, Doudna JA. Crystal structure of the ribonucleoprotein core of the signal recognition particle. Science (New York, N.Y.). 287: 1232-9. PMID 10678824 DOI: 10.1126/Science.287.5456.1232 |
0.804 |
|
| 2000 |
Ferré-D'Amaré AR, Doudna JA. Crystallization and structure determination of a hepatitis delta virus ribozyme: use of the RNA-binding protein U1A as a crystallization module. Journal of Molecular Biology. 295: 541-56. PMID 10623545 DOI: 10.1006/Jmbi.1999.3398 |
0.696 |
|
| 1999 |
Doudna JA. Ribosomes: Cashing in on crystals Current Biology. 9: R731-R734. PMID 10530999 DOI: 10.1016/S0960-9822(99)80470-9 |
0.479 |
|
| 1999 |
Kieft JS, Zhou K, Jubin R, Murray MG, Lau JY, Doudna JA. The hepatitis C virus internal ribosome entry site adopts an ion-dependent tertiary fold. Journal of Molecular Biology. 292: 513-29. PMID 10497018 DOI: 10.1006/Jmbi.1999.3095 |
0.703 |
|
| 1999 |
Batey RT, Rambo RP, Doudna JA. Tertiary Motifs in RNA Structure and Folding. Angewandte Chemie (International Ed. in English). 38: 2326-2343. PMID 10458781 DOI: 10.1002/(Sici)1521-3773(19990816)38:16<2326::Aid-Anie2326>3.0.Co;2-3 |
0.815 |
|
| 1999 |
Ferré-D'Amaré AR, Doudna JA. RNA folds: insights from recent crystal structures. Annual Review of Biophysics and Biomolecular Structure. 28: 57-73. PMID 10410795 DOI: 10.1146/Annurev.Biophys.28.1.57 |
0.727 |
|
| 1999 |
Wadkins TS, Perrotta AT, Ferré-D'Amaré AR, Doudna JA, Been MD. A nested double pseudoknot is required for self-cleavage activity of both the genomic and antigenomic hepatitis delta virus ribozymes. Rna (New York, N.Y.). 5: 720-7. PMID 10376872 DOI: 10.1017/S1355838299990209 |
0.661 |
|
| 1999 |
Doherty EA, Herschlag D, Doudna JA. Assembly of an exceptionally stable RNA tertiary interface in a group I ribozyme. Biochemistry. 38: 2982-90. PMID 10074350 DOI: 10.1021/Bi982113P |
0.836 |
|
| 1999 |
Manoj N, Srinivas VR, Surolia A, Vijayan M, Suguna K, Ravishankar R, Schwarzenbacher R, Zeth K, Diederichs, Kostner GM, Gries A, Laggner P, Prassl R, Madhusudan, Akamine P, ... ... Doudna JA, et al. Contributory presentations/posters Journal of Biosciences. 24: 33-198. DOI: 10.1007/Bf02989373 |
0.748 |
|
| 1999 |
Batey R, Rambo R, Doudna J. Tertiäre Motive bei Struktur und Faltung von RNA Angewandte Chemie. 111: 2472-2491. DOI: 10.1002/(Sici)1521-3757(19990816)111:16<2472::Aid-Ange2472>3.0.Co;2-M |
0.804 |
|
| 1998 |
Basu S, Rambo RP, Strauss-Soukup J, Cate JH, Ferré-D'Amaré AR, Strobel SA, Doudna JA. A specific monovalent metal ion integral to the AA platform of the RNA tetraloop receptor. Nature Structural Biology. 5: 986-92. PMID 9808044 DOI: 10.1038/2960 |
0.812 |
|
| 1998 |
Ferré-D'Amaré AR, Zhou K, Doudna JA. Crystal structure of a hepatitis delta virus ribozyme. Nature. 395: 567-74. PMID 9783582 DOI: 10.1038/26912 |
0.701 |
|
| 1998 |
Doudna JA. Ribozymes: The hammerhead swings into action Current Biology. 8: R495-R497. PMID 9663384 DOI: 10.1016/S0960-9822(98)70316-1 |
0.415 |
|
| 1998 |
Ferré-D'Amaré AR, Zhou K, Doudna JA. A general module for RNA crystallization. Journal of Molecular Biology. 279: 621-31. PMID 9641982 DOI: 10.1006/Jmbi.1998.1789 |
0.674 |
|
| 1998 |
Batey RT, Doudna JA. The parallel universe of RNA folding. Nature Structural Biology. 5: 337-40. PMID 9586989 DOI: 10.1038/Nsb0598-337 |
0.712 |
|
| 1998 |
Doherty EA, Rambo R, Doudna JA. Assembly of a ribozyme active site Faseb Journal. 12: A1315. |
0.271 |
|
| 1997 |
Doudna JA, Doherty EA. Emerging themes in RNA folding. Folding & Design. 2: R65-70. PMID 9377708 DOI: 10.1016/S1359-0278(97)00035-7 |
0.849 |
|
| 1997 |
Doudna JA. A molecular contortionist Nature. 388: 830-831. PMID 9278040 DOI: 10.1038/42139 |
0.312 |
|
| 1997 |
Strobel SA, Doudna JA. RNA seeing double: close-packing of helices in RNA tertiary structure. Trends in Biochemical Sciences. 22: 262-6. PMID 9255068 DOI: 10.1016/S0968-0004(97)01056-6 |
0.719 |
|
| 1997 |
Cate JH, Hanna RL, Doudna JA. A magnesium ion core at the heart of a ribozyme domain. Nature Structural Biology. 4: 553-8. PMID 9228948 DOI: 10.1038/Nsb0797-553 |
0.804 |
|
| 1997 |
Cate JH, Doudna JA. A sparse matrix approach to crystallizing ribozymes and RNA motifs Methods in Molecular Biology (Clifton, N.J.). 74: 379-386. PMID 9204453 DOI: 10.1385/0-89603-389-9:379 |
0.775 |
|
| 1997 |
Ferré-d'Amaré AR, Doudna JA. Establishing suitability of RNA preparations for crystallization. Determination of polydispersity Methods in Molecular Biology (Clifton, N.J.). 74: 371-377. PMID 9204452 DOI: 10.1385/0-89603-389-9:371 |
0.502 |
|
| 1997 |
Doudna JA. Preparation of homogeneous ribozyme RNA for crystallization Methods in Molecular Biology (Clifton, N.J.). 74: 365-370. PMID 9204451 DOI: 10.1385/0-89603-389-9:365 |
0.508 |
|
| 1997 |
Doudna JA, Cate JH. RNA structure: Crystal clear? Current Opinion in Structural Biology. 7: 310-316. PMID 9204271 DOI: 10.1016/S0959-440X(97)80045-0 |
0.811 |
|
| 1997 |
Doherty EA, Doudna JA. The P4-P6 domain directs higher order folding of the Tetrahymena ribozyme core. Biochemistry. 36: 3159-69. PMID 9115992 DOI: 10.1021/Bi962428+ |
0.779 |
|
| 1997 |
Gate JH, Hanna RL, Doudna JA. A metal ion core at the heart of a l. argk ribozyme domain Faseb Journal. 11: A1445. |
0.218 |
|
| 1997 |
Cate JH, Doherty EA, Doudna JA. Crystal structure of A group I ribozyme domain reveals principles of higher order RNA folding Protein Engineering. 10: 41. |
0.767 |
|
| 1996 |
Cate JH, Doudna JA. Metal-binding sites in the major groove of a large ribozyme domain Structure. 4: 1221-1229. PMID 8939748 DOI: 10.1016/S0969-2126(96)00129-3 |
0.802 |
|
| 1996 |
Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Szewczak AA, Kundrot CE, Cech TR, Doudna JA. RNA tertiary structure mediation by adenosine platforms. Science (New York, N.Y.). 273: 1696-9. PMID 8781229 DOI: 10.1126/Science.273.5282.1696 |
0.847 |
|
| 1996 |
Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Kundrot CE, Cech TR, Doudna JA. Crystal structure of a group I ribozyme domain: principles of RNA packing. Science (New York, N.Y.). 273: 1678-85. PMID 8781224 DOI: 10.1126/Science.273.5282.1678 |
0.829 |
|
| 1996 |
Ferré-D'Amaré AR, Doudna JA. Use of cis- and trans-ribozymes to remove 5′ and 3′ heterogeneities from milligrams of in vitro transcribed RNA Nucleic Acids Research. 24: 977-978. PMID 8600468 DOI: 10.1093/Nar/24.5.977 |
0.732 |
|
| 1996 |
Jones JT, Barnes CL, Lietzke SE, Weichenrieder O, Doudna JA, Kundrot CE. Preliminary X-ray diffraction studies of an RNA pseudoknot that inhibits HIV-1 reverse transcriptase Acta Crystallographica Section D: Biological Crystallography. 52: 1018-1020. DOI: 10.1107/S0907444996004234 |
0.336 |
|
| 1995 |
Doudna JA. Hammerhead ribozyme structure: U-turn for RNA structural biology Structure. 3: 747-750. PMID 7582890 DOI: 10.1016/S0969-2126(01)00208-8 |
0.537 |
|
| 1995 |
Doudna JA, Cech TR, Sullenger BA. Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor. Proceedings of the National Academy of Sciences of the United States of America. 92: 2355-9. PMID 7534420 DOI: 10.1073/Pnas.92.6.2355 |
0.617 |
|
| 1995 |
Doudna JA, Cech TR. Self-assembly of a group I intron active site from its component tertiary structural domains. Rna (New York, N.Y.). 1: 36-45. PMID 7489486 |
0.507 |
|
| 1994 |
Doudna JA. Hammering out the shape of a ribozyme Structure. 2: 1271-1272. PMID 7704535 DOI: 10.1016/S0969-2126(94)00127-8 |
0.354 |
|
| 1993 |
Doudna JA, Grosshans C, Gooding A, Kundrot CE. Crystallization of ribozymes and small RNA motifs by a sparse matrix approach. Proceedings of the National Academy of Sciences of the United States of America. 90: 7829-33. PMID 8356090 |
0.498 |
|
| 1993 |
Doudna JA, Usman N, Szostak JW. Ribozyme-catalyzed primer extension by trinucleotides: a model for the RNA-catalyzed replication of RNA. Biochemistry. 32: 2111-5. PMID 7680575 DOI: 10.1021/Bi00059A032 |
0.718 |
|
| 1991 |
Bartel DP, Doudna JA, Usman N, Szostak JW. Template-directed primer extension catalyzed by the Tetrahymena ribozyme. Molecular and Cellular Biology. 11: 3390-4. PMID 2038341 DOI: 10.1128/Mcb.11.6.3390 |
0.778 |
|
| 1991 |
Musier-Forsyth K, Usman N, Scaringe S, Doudna J, Green R, Schimmel P. Specificity for aminoacylation of an RNA helix: an unpaired, exocyclic amino group in the minor groove. Science (New York, N.Y.). 253: 784-6. PMID 1876835 DOI: 10.1126/Science.1876835 |
0.625 |
|
| 1991 |
Doudna JA, Couture S, Szostak JW. A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis. Science (New York, N.Y.). 251: 1605-8. PMID 1707185 DOI: 10.1126/Science.1707185 |
0.719 |
|
| 1990 |
Doudna JA, Szostak JW, Rich A, Usman N. Chemical synthesis of oligoribonucleotides containing 2-aminopurine: substrates for the investigation of ribozyme function. The Journal of Organic Chemistry. 55: 5547-9. PMID 11540922 DOI: 10.1021/Jo00308A003 |
0.66 |
|
| 1990 |
Couture S, Ellington AD, Gerber AS, Cherry JM, Doudna JA, Green R, Hanna M, Pace U, Rajagopal J, Szostak JW. Mutational analysis of conserved nucleotides in a self-splicing group I intron. Journal of Molecular Biology. 215: 345-58. PMID 1700131 DOI: 10.1016/S0022-2836(05)80356-0 |
0.743 |
|
| 1989 |
Doudna JA, Szostak JW. Miniribozymes, small derivatives of the sunY intron, are catalytically active. Molecular and Cellular Biology. 9: 5480-3. PMID 2685567 DOI: 10.1128/Mcb.9.12.5480 |
0.625 |
|
| 1989 |
Doudna JA, Cormack BP, Szostak JW. RNA structure, not sequence, determines the 5' splice-site specificity of a group I intron. Proceedings of the National Academy of Sciences of the United States of America. 86: 7402-6. PMID 2678103 DOI: 10.1073/Pnas.86.19.7402 |
0.697 |
|
| 1989 |
Doudna JA, Szostak JW. RNA-catalysed synthesis of complementary-strand RNA. Nature. 339: 519-22. PMID 2660003 DOI: 10.1038/339519A0 |
0.748 |
|
| 1989 |
Rajagopal J, Doudna JA, Szostak JW. Stereochemical course of catalysis by the Tetrahymena ribozyme. Science (New York, N.Y.). 244: 692-4. PMID 2470151 DOI: 10.1126/Science.2470151 |
0.689 |
|
| 1989 |
Doudna JA, Szostak JW. RNA-catalysed synthesis of complementary strand RNA Trends in Genetics. 5: 323. DOI: 10.1016/0168-9525(89)90125-X |
0.744 |
|
| 1987 |
Doudna JA, Gerber AS, Cherry JM, Szostak JW. Genetic dissection of an RNA enzyme. Cold Spring Harbor Symposia On Quantitative Biology. 52: 173-80. PMID 2456876 DOI: 10.1101/Sqb.1987.052.01.022 |
0.69 |
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