| Year |
Citation |
Score |
| 2022 |
Su C, Gao L, May CL, Pippin JA, Boehm K, Lee M, Liu C, Pahl MC, Golson ML, Naji A, Grant SFA, Wells AD, Kaestner KH. 3D chromatin maps of the human pancreas reveal lineage-specific regulatory architecture of T2D risk. Cell Metabolism. 34: 1394-1409.e4. PMID 36070683 DOI: 10.1016/j.cmet.2022.08.014 |
0.741 |
|
| 2022 |
Doliba NM, Rozo AV, Roman J, Qin W, Traum D, Gao L, Liu J, Manduchi E, Liu C, Golson ML, Vahedi G, Naji A, Matschinsky FM, Atkinson MA, Powers AC, ... ... Kaestner KH, et al. α Cell dysfunction in islets from nondiabetic, glutamic acid decarboxylase autoantibody-positive individuals. The Journal of Clinical Investigation. 132. PMID 35642629 DOI: 10.1172/JCI156243 |
0.723 |
|
| 2022 |
Lasconi C, Pahl MC, Pippin JA, Su C, Johnson ME, Chesi A, Boehm K, Manduchi E, Ou K, Golson ML, Wells AD, Kaestner KH, Grant SFA. Variant-to-gene-mapping analyses reveal a role for pancreatic islet cells in conferring genetic susceptibility to sleep-related traits. Sleep. PMID 35537191 DOI: 10.1093/sleep/zsac109 |
0.702 |
|
| 2022 |
Fasolino M, Schwartz GW, Patil AR, Mongia A, Golson ML, Wang YJ, Morgan A, Liu C, Schug J, Liu J, Wu M, Traum D, Kondo A, May CL, Goldman N, ... ... Kaestner KH, et al. Single-cell multi-omics analysis of human pancreatic islets reveals novel cellular states in type 1 diabetes. Nature Metabolism. 4: 284-299. PMID 35228745 DOI: 10.1038/s42255-022-00531-x |
0.73 |
|
| 2021 |
Kondo A, Kaestner KH. FoxL1 mesenchymal cells are a critical source of Wnt5a for midgut elongation during mouse embryonic intestinal development. Cells & Development. 165: 203662. PMID 33993983 DOI: 10.1016/j.cdev.2021.203662 |
0.309 |
|
| 2021 |
Miao Z, Balzer MS, Ma Z, Liu H, Wu J, Shrestha R, Aranyi T, Kwan A, Kondo A, Pontoglio M, Kim J, Li M, Kaestner KH, Susztak K. Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets. Nature Communications. 12: 2277. PMID 33859189 DOI: 10.1038/s41467-021-22266-1 |
0.312 |
|
| 2021 |
Kondo A, Kaestner KH. FoxL1 mesenchymal cells are a critical source of Wnt5a for midgut elongation during mouse embryonic intestinal development. Cells & Development. 165. PMID 33778801 DOI: 10.1016/j.cdev.2021.203662 |
0.308 |
|
| 2020 |
Coate KC, Cha J, Shrestha S, Wang W, Gonçalves LM, Almaça J, Kapp ME, Fasolino M, Morgan A, Dai C, Saunders DC, Bottino R, Aramandla R, Jenkins R, Stein R, ... Kaestner KH, et al. SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Pancreas but are Not Enriched in Islet Endocrine Cells. Biorxiv : the Preprint Server For Biology. PMID 33106804 DOI: 10.1101/2020.08.31.275719 |
0.302 |
|
| 2020 |
Atkinson MA, Campbell-Thompson M, Kusmartseva I, Kaestner KH. Organisation of the human pancreas in health and in diabetes. Diabetologia. 63: 1966-1973. PMID 32894306 DOI: 10.1007/S00125-020-05203-7 |
0.306 |
|
| 2020 |
Avrahami D, Wang YJ, Schug J, Feleke E, Gao L, Liu C, Consortium HPAP, Naji A, Glaser B, Kaestner KH. Single cell transcriptomics of human islet ontogeny defines the molecular basis of β cell dedifferentiation in T2D. Molecular Metabolism. 101057. PMID 32739450 DOI: 10.1016/J.Molmet.2020.101057 |
0.367 |
|
| 2020 |
Wu H, Reizel T, Wang YJ, Lapiro JL, Kren BT, Schug J, Rao S, Morgan A, Herman A, Shekels LL, Rassette MS, Lane AN, Cassel T, Fan TWM, Manivel JC, ... ... Kaestner KH, et al. A negative reciprocal regulatory axis between cyclin D1 and HNF4α modulates cell cycle progression and metabolism in the liver. Proceedings of the National Academy of Sciences of the United States of America. PMID 32631996 DOI: 10.1073/Pnas.2002898117 |
0.378 |
|
| 2020 |
Reizel Y, Morgan A, Gao L, Lan Y, Manduchi E, Waite EL, Wang AW, Wells A, Kaestner KH. Collapse of the hepatic gene regulatory network in the absence of FoxA factors. Genes & Development. PMID 32561546 DOI: 10.1101/Gad.337691.120 |
0.392 |
|
| 2020 |
Szigety KM, Liu F, Yuan CY, Moran DJ, Horrell J, Gochnauer HR, Cohen RN, Katz JP, Kaestner KH, Seykora JT, Tobias JW, Lazar MA, Xu M, Millar SE. HDAC3 ensures stepwise epidermal stratification via NCoR/SMRT-reliant mechanisms independent of its histone deacetylase activity. Genes & Development. PMID 32467224 DOI: 10.1101/Gad.333674.119 |
0.34 |
|
| 2020 |
Fasolino M, Goldman N, Wang W, Cattau B, Zhou Y, Petrovic J, Link VM, Cote A, Chandra A, Silverman M, Joyce EF, Little SC, Kaestner KH, Naji A, et al. Genetic Variation in Type 1 Diabetes Reconfigures the 3D Chromatin Organization of T Cells and Alters Gene Expression. Immunity. PMID 32049053 DOI: 10.1016/J.Immuni.2020.01.003 |
0.371 |
|
| 2020 |
Doliba NM, Rozo AV, Qin W, Roman J, Liu C, Naji A, Kaestner KH, Stoffers DA, Matschinsky F. 322-OR: Impairment of Alpha-Cell Bioenergetics Contributes to Increased Basal Yet Decreased Glucose Stimulated Oxygen Consumption Rates of Isolated Human Pancreatic Islets in T1DM and T2DM Diabetes. 69. DOI: 10.2337/Db20-322-Or |
0.304 |
|
| 2020 |
Dattaroy D, Barella LF, Pydi SP, Cui Y, Kaestner KH, Wess J. 2129-P: Glucagon Secretion from Pancreatic Islets Is Regulated by Beta-Arrestin-1 Diabetes. 69. DOI: 10.2337/Db20-2129-P |
0.401 |
|
| 2020 |
Shuman* L, Buckwalter J, Wildermuth T, Kaestner K, Mendelsohn C, DeGraff D. MP28-17 FOXA1 EXPRESSION IS REQUIRED FOR MAINTENANCE OF SUPERFICIAL UMBRELLA CELLS IN THE UROTHELIUM The Journal of Urology. 203: e426. DOI: 10.1097/Ju.0000000000000867.017 |
0.364 |
|
| 2019 |
Scherm MG, Serr I, Zahm AM, Schug J, Bellusci S, Manfredini R, Salb VK, Gerlach K, Weigmann B, Ziegler AG, Kaestner KH, Daniel C. miRNA142-3p targets Tet2 and impairs Treg differentiation and stability in models of type 1 diabetes. Nature Communications. 10: 5697. PMID 31836704 DOI: 10.1038/S41467-019-13587-3 |
0.316 |
|
| 2019 |
Zahm AM, Wang AW, Wang YJ, Schug J, Wangensteen KJ, Kaestner KH. High-content Screen Identifies MicroRNAs Required for Liver Repopulation After Injury in Mice. Gastroenterology. PMID 31759059 DOI: 10.1053/J.Gastro.2019.11.025 |
0.3 |
|
| 2019 |
Jin W, Mulas F, Gaertner B, Sui Y, Wang J, Matta I, Zeng C, Vinckier N, Wang A, Nguyen-Ngoc KV, Chiou J, Kaestner KH, Frazer KA, Carrano AC, Shih HP, et al. A Network of microRNAs Acts to Promote Cell Cycle Exit and Differentiation of Human Pancreatic Endocrine Cells. Iscience. 21: 681-694. PMID 31733514 DOI: 10.1016/J.Isci.2019.10.063 |
0.359 |
|
| 2019 |
Osei-Amponsa V, Buckwalter JM, Shuman L, Zheng Z, Yamashita H, Walter V, Wildermuth T, Ellis-Mohl J, Liu C, Warrick JI, Shantz LM, Feehan RP, Al-Ahmadie H, Mendelsohn C, Raman JD, ... Kaestner KH, et al. Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer. Oncogene. PMID 31636388 DOI: 10.1038/S41388-019-1063-4 |
0.335 |
|
| 2019 |
Wang AW, Wang YJ, Zahm AM, Morgan AR, Wangensteen KJ, Kaestner KH. The dynamic chromatin architecture of the regenerating liver. Cellular and Molecular Gastroenterology and Hepatology. PMID 31629814 DOI: 10.1016/J.Jcmgh.2019.09.006 |
0.305 |
|
| 2019 |
Stine RR, Sakers AP, TeSlaa T, Kissig M, Stine ZE, Kwon CW, Cheng L, Lim HW, Kaestner KH, Rabinowitz JD, Seale P. PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism. Cell Stem Cell. PMID 31564549 DOI: 10.1016/J.Stem.2019.08.017 |
0.362 |
|
| 2019 |
Avrahami D, Kaestner KH. The dynamic methylome of islets in health and disease. Molecular Metabolism. 27: S25-S32. PMID 31500828 DOI: 10.1016/J.Molmet.2019.06.007 |
0.345 |
|
| 2019 |
Scherm MG, Serr I, Kaestner KH, Daniel C. The role of T cell miRNAs for regulatory T cell induction in islet autoimmunity. Molecular Metabolism. 27: S122-S128. PMID 31500823 DOI: 10.1016/J.Molmet.2019.06.009 |
0.31 |
|
| 2019 |
Kondo A, Kaestner KH. Emerging diverse roles of telocytes. Development (Cambridge, England). 146. PMID 31311805 DOI: 10.1242/Dev.175018 |
0.353 |
|
| 2019 |
Kaestner KH, Powers AC, Naji A, Atkinson MA. NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP). Diabetes. PMID 31127054 DOI: 10.2337/Db19-0058 |
0.34 |
|
| 2019 |
Zhu L, Dattaroy D, Pham J, Wang L, Barella LF, Cui Y, Wilkins KJ, Roth BL, Hochgeschwender U, Matschinsky FM, Kaestner KH, Doliba NM, Wess J. Intra-islet glucagon signaling is critical for maintaining glucose homeostasis. Jci Insight. 5. PMID 31012868 DOI: 10.1172/Jci.Insight.127994 |
0.394 |
|
| 2019 |
Kaestner KH. The intestinal stem cell niche - a central role for Foxl1-expressing subepithelial telocytes. Cellular and Molecular Gastroenterology and Hepatology. PMID 30965141 DOI: 10.1016/J.Jcmgh.2019.04.001 |
0.376 |
|
| 2019 |
Wang YJ, Traum D, Schug J, Gao L, Liu C, Atkinson MA, Powers AC, Feldman MD, Naji A, Chang KM, Kaestner KH. Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes. Cell Metabolism. PMID 30713110 DOI: 10.1016/J.Cmet.2019.01.003 |
0.34 |
|
| 2019 |
Ho K, Perez RF, Kim R, Xu L, Teguh DA, Gamer L, Kozhemyakina E, Lassar A, Li Y, Kaestner K, Whitman M, Rosen V, Ionescu A. The role of FoxA2 transcription factor as potential regulator of articular cartilage hypertrophy and OA progression Osteoarthritis and Cartilage. 27: S157-S158. DOI: 10.1016/J.Joca.2019.02.231 |
0.329 |
|
| 2019 |
Szigety K, Liu F, Katz J, Kaestner K, Lazar M, Millar S. 901 HDAC3 complexes with KLF4 and NCoR/SMRT to control epidermal gene expression Journal of Investigative Dermatology. 139. DOI: 10.1016/J.Jid.2019.03.977 |
0.315 |
|
| 2018 |
Wang YJ, Kaestner KH. Single-Cell RNA-Seq of the Pancreatic Islets--a Promise Not yet Fulfilled? Cell Metabolism. PMID 30581120 DOI: 10.1016/J.Cmet.2018.11.016 |
0.387 |
|
| 2018 |
Camolotto SA, Pattabiraman S, Mosbruger TL, Jones A, Belova VK, Orstad G, Streiff M, Salmond L, Stubben C, Kaestner KH, Snyder EL. FoxA1 and FoxA2 drive gastric differentiation and suppress squamous identity in NKX2-1-negative lung cancer. Elife. 7. PMID 30475207 DOI: 10.7554/Elife.38579 |
0.301 |
|
| 2018 |
Cyphert HA, Walker EM, Hang Y, Dhawan S, Haliyur R, Bonatakis L, Avrahami D, Brissova M, Kaestner KH, Bhushan A, Powers AC, Stein R. "Examining How the MAFB Transcription Factor Affects Islet β Cell Function Postnatally". Diabetes. PMID 30425060 DOI: 10.2337/Db18-0903 |
0.377 |
|
| 2018 |
Ou K, Yu M, Moss NG, Wang YJ, Wang AW, Nguyen SC, Jiang C, Feleke E, Kameswaran V, Joyce EF, Naji A, Glaser B, Avrahami D, Kaestner KH. Targeted demethylation at the CDKN1C/p57 induces human β cell replication. The Journal of Clinical Investigation. PMID 30352048 DOI: 10.1172/Jci99170 |
0.405 |
|
| 2018 |
Kameswaran V, Golson M, Rodriguez MR, Ou K, Wang YJ, Zhang J, Pasquali L, Kaestner KH. The Dysregulation of the - Locus in Islets From Type 2 Diabetics is Mimicked by Targeted Epimutation of its Promoter with TALE-DNMT Constructs. Diabetes. PMID 30084829 DOI: 10.2337/Db17-0682 |
0.757 |
|
| 2018 |
Ackermann AM, Moss NG, Kaestner KH. GABA and Artesunate Do Not Induce Pancreatic α-to-β Cell Transdifferentiation In Vivo. Cell Metabolism. PMID 30057067 DOI: 10.1016/J.Cmet.2018.07.002 |
0.354 |
|
| 2018 |
Cohen-Tayar Y, Cohen H, Mitiagin Y, Abarbanel Z, Levy C, Idelson M, Reubinoff B, Itzkovitz S, Raviv S, Kaestner K, Blinder P, Elkon R, Ashery-Padan R. Pax6 regulation of in the retinal pigmented epithelium controls its timely differentiation and choroid vasculature development. Development (Cambridge, England). PMID 29986868 DOI: 10.1242/Dev.163691 |
0.36 |
|
| 2018 |
Terry NA, Ngaba LV, Wilkins BJ, Pi D, Gheewala N, Kaestner KH. Lipid Malabsorption from Altered Hormonal Signaling Changes Early Gut Microbial Responses. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 29953253 DOI: 10.1152/Ajpgi.00135.2018 |
0.401 |
|
| 2018 |
Reizel Y, Sabag O, Skversky Y, Spiro A, Steinberg B, Bernstein D, Wang A, Kieckhaefer J, Li C, Pikarsky E, Levin-Klein R, Goren A, Rajewsky K, Kaestner KH, Cedar H. Postnatal DNA demethylation and its role in tissue maturation. Nature Communications. 9: 2040. PMID 29795194 DOI: 10.1038/S41467-018-04456-6 |
0.367 |
|
| 2018 |
Shoshkes-Carmel M, Wang YJ, Wangensteen KJ, Tóth B, Kondo A, Massassa EE, Itzkovitz S, Kaestner KH. Subepithelial telocytes are an important source of Wnts that supports intestinal crypts. Nature. PMID 29720649 DOI: 10.1038/S41586-018-0084-4 |
0.364 |
|
| 2018 |
Ou K, Zhang J, Jiao Y, Wang ZV, Scherer P, Kaestner KH. Overexpression of ST5, an activator of Ras, has no effect on β-cell proliferation in adult mice. Molecular Metabolism. PMID 29650351 DOI: 10.1016/J.Molmet.2018.03.009 |
0.343 |
|
| 2018 |
Wang AW, Wangensteen KJ, Wang YJ, Zahm AM, Moss NG, Erez N, Kaestner KH. TRAP-seq identifies cystine/glutamate antiporter as a driver of recovery from liver injury. The Journal of Clinical Investigation. PMID 29517978 DOI: 10.1172/Jci95120 |
0.37 |
|
| 2018 |
Gazala SA, Horwitz E, Ben-Haroush Schyr R, Bardugo A, Israeli H, Hija A, Schug J, Shin S, Dor Y, Kaestner KH, Ben-Zvi D. Sleeve Gastrectomy Improves Glycemia Independent of Weight Loss by Restoring Hepatic Insulin Sensitivity. Diabetes. PMID 29475831 DOI: 10.2337/Db17-1028 |
0.325 |
|
| 2018 |
Serr I, Scherm MG, Zahm AM, Schug J, Flynn VK, Hippich M, Kälin S, Becker M, Achenbach P, Nikolaev A, Gerlach K, Liebsch N, Loretz B, Lehr CM, Kirchner B, ... ... Kaestner KH, et al. A miRNA181a/NFAT5 axis links impaired T cell tolerance induction with autoimmune type 1 diabetes. Science Translational Medicine. 10. PMID 29298866 DOI: 10.1126/Scitranslmed.Aag1782 |
0.357 |
|
| 2018 |
Osei Amponsa V, Zheng Z, Walter V, Warrick J, Mendelsohn C, Kaestner K, Wu X, Raman J, DeGraff D. Novel transgenic knockout model of basal-squamous bladder cancer. Journal of Clinical Oncology. 36: 459-459. DOI: 10.1200/Jco.2018.36.6_Suppl.459 |
0.319 |
|
| 2017 |
Swisa A, Kaestner KH, Dor Y. Transcriptional Noise and Somatic Mutations in the Aging Pancreas. Cell Metabolism. 26: 809-811. PMID 29211979 DOI: 10.1016/J.Cmet.2017.11.009 |
0.355 |
|
| 2017 |
Wangensteen KJ, Wang YJ, Dou Z, Wang AW, Mosleh-Shirazi E, Horlbeck MA, Gilbert LA, Weissman JS, Berger SL, Kaestner KH. Combinatorial genetics in liver repopulation and carcinogenesis with a novel in vivo CRISPR activation platform. Hepatology (Baltimore, Md.). PMID 29091290 DOI: 10.1002/Hep.29626 |
0.416 |
|
| 2017 |
Kim JH, Hedrick S, Tsai WW, Wiater E, Le Lay J, Kaestner KH, Leblanc M, Loar A, Montminy M. CREB coactivators CRTC2 and CRTC3 modulate bone marrow hematopoiesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 29078378 DOI: 10.1073/Pnas.1712616114 |
0.383 |
|
| 2017 |
Sacchetti C, Bai Y, Stanford SM, Di Benedetto P, Cipriani P, Santelli E, Piera-Velazquez S, Chernitskiy V, Kiosses WB, Ceponis A, Kaestner KH, Boin F, Jimenez SA, Giacomelli R, Zhang ZY, et al. PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis. Nature Communications. 8: 1060. PMID 29057934 DOI: 10.1038/S41467-017-01168-1 |
0.325 |
|
| 2017 |
Dou Z, Ghosh K, Vizioli MG, Zhu J, Sen P, Wangensteen KJ, Simithy J, Lan Y, Lin Y, Zhou Z, Capell BC, Xu C, Xu M, Kieckhaefer JE, Jiang T, ... ... Kaestner KH, et al. Cytoplasmic chromatin triggers inflammation in senescence and cancer. Nature. PMID 28976970 DOI: 10.1038/Nature24050 |
0.38 |
|
| 2017 |
Golson ML, Kaestner KH. Epigenetics in formation, function, and failure of the endocrine pancreas. Molecular Metabolism. 6: 1066-1076. PMID 28951829 DOI: 10.1016/J.Molmet.2017.05.015 |
0.754 |
|
| 2017 |
Avrahami D, Wang YJ, Klochendler A, Dor Y, Glaser B, Kaestner KH. β-Cells are not uniform after all-Novel insights into molecular heterogeneity of insulin-secreting cells. Diabetes, Obesity & Metabolism. 19: 147-152. PMID 28880481 DOI: 10.1111/Dom.13019 |
0.365 |
|
| 2017 |
Galivo F, Benedetti E, Wang Y, Pelz C, Schug J, Kaestner KH, Grompe M. Reprogramming human gallbladder cells into insulin-producing β-like cells. Plos One. 12: e0181812. PMID 28813430 DOI: 10.1371/Journal.Pone.0181812 |
0.44 |
|
| 2017 |
Xu M, Horrell J, Snitow M, Cui J, Gochnauer H, Syrett CM, Kallish S, Seykora JT, Liu F, Gaillard D, Katz JP, Kaestner KH, Levin B, Mansfield C, Douglas JE, et al. WNT10A mutation causes ectodermal dysplasia by impairing progenitor cell proliferation and KLF4-mediated differentiation. Nature Communications. 8: 15397. PMID 28589954 DOI: 10.1038/Ncomms15397 |
0.392 |
|
| 2017 |
Li C, Ackermann AM, Boodhansingh KE, Bhatti TR, Liu C, Schug J, Doliba N, Han B, Cosgrove KE, Banerjee I, Matschinsky FM, Nissim I, Kaestner KH, Naji A, Adzick NS, et al. Functional and Metabolomic Consequences of ATP-dependent Potassium Channel Inactivation in Human Islets. Diabetes. PMID 28442472 DOI: 10.2337/Db17-0029 |
0.342 |
|
| 2017 |
van der Meulen T, Mawla AM, DiGruccio MR, Adams MW, Nies V, Dólleman S, Liu S, Ackermann AM, Cáceres E, Hunter AE, Kaestner KH, Donaldson CJ, Huising MO. Virgin Beta Cells Persist throughout Life at a Neogenic Niche within Pancreatic Islets. Cell Metabolism. 25: 911-926.e6. PMID 28380380 DOI: 10.1016/J.Cmet.2017.03.017 |
0.36 |
|
| 2017 |
Ackermann AM, Zhang J, Heller A, Briker A, Kaestner KH. High-fidelity Glucagon-CreER mouse line generated by CRISPR-Cas9 assisted gene targeting. Molecular Metabolism. 6: 236-244. PMID 28271030 DOI: 10.1016/J.Molmet.2017.01.003 |
0.403 |
|
| 2017 |
McFadden VC, Shalaby RE, Iram S, Oropeza CE, Landolfi JA, Lyubimov AV, Maienschein-Cline M, Green S, Kaestner KH, McLachlan A. Hepatic deficiency of the pioneer transcription factor FoxA restricts hepatitis B virus biosynthesis by the developmental regulation of viral DNA methylation. Plos Pathogens. 13: e1006239. PMID 28235042 DOI: 10.1371/Journal.Ppat.1006239 |
0.41 |
|
| 2017 |
Zhang J, Kaestner KH. Epigenetic Analysis of Endocrine Cell Subtypes from Human Pancreatic Islets. Methods in Molecular Biology (Clifton, N.J.). 1507: 95-111. PMID 27832535 DOI: 10.1007/978-1-4939-6518-2_8 |
0.428 |
|
| 2017 |
Helman A, Avrahami D, Klochendler A, Glaser B, Kaestner KH, Ben-Porath I, Dor Y. Effects of ageing and senescence on pancreatic β-cell function. Diabetes, Obesity & Metabolism. 58-62. PMID 27615132 DOI: 10.1111/Dom.12719 |
0.373 |
|
| 2016 |
Golson ML, Kaestner KH. Fox transcription factors: from development to disease. Development (Cambridge, England). 143: 4558-4570. PMID 27965437 DOI: 10.1242/Dev.112672 |
0.734 |
|
| 2016 |
Gutiérrez GD, Bender AS, Cirulli V, Mastracci TL, Kelly SM, Tsirigos A, Kaestner KH, Sussel L. Pancreatic β cell identity requires continual repression of non-β cell programs. The Journal of Clinical Investigation. PMID 27941248 DOI: 10.1172/Jci88017 |
0.399 |
|
| 2016 |
Ediger BN, Lim HW, Juliana C, Groff DN, Williams LT, Dominguez G, Liu JH, Taylor BL, Walp ER, Kameswaran V, Yang J, Liu C, Hunter CS, Kaestner KH, Naji A, et al. LIM domain-binding 1 maintains the terminally differentiated state of pancreatic β cells. The Journal of Clinical Investigation. PMID 27941246 DOI: 10.1172/Jci88016 |
0.427 |
|
| 2016 |
Swisa A, Avrahami D, Eden N, Zhang J, Feleke E, Dahan T, Cohen-Tayar Y, Stolovich-Rain M, Kaestner KH, Glaser B, Ashery-Padan R, Dor Y. PAX6 maintains β cell identity by repressing genes of alternative islet cell types. The Journal of Clinical Investigation. PMID 27941241 DOI: 10.1172/Jci88015 |
0.416 |
|
| 2016 |
Bernstein D, Golson ML, Kaestner KH. Epigenetic control of β-cell function and failure. Diabetes Research and Clinical Practice. 123: 24-36. PMID 27918975 DOI: 10.1016/J.Diabres.2016.11.009 |
0.728 |
|
| 2016 |
Kim R, Sheaffer KL, Choi I, Won KJ, Kaestner KH. Epigenetic regulation of intestinal stem cells by Tet1-mediated DNA hydroxymethylation. Genes & Development. PMID 27856615 DOI: 10.1101/Gad.288035.116 |
0.423 |
|
| 2016 |
Wang YJ, Golson ML, Schug J, Traum D, Liu C, Vivek K, Dorrell C, Naji A, Powers AC, Chang KM, Grompe M, Kaestner KH. Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas. Cell Metabolism. 24: 616-626. PMID 27732837 DOI: 10.1016/J.Cmet.2016.09.007 |
0.746 |
|
| 2016 |
Dorrell C, Schug J, Canaday PS, Russ HA, Tarlow BD, Grompe MT, Horton T, Hebrok M, Streeter PR, Kaestner KH, Grompe M. Human islets contain four distinct subtypes of β cells. Nature Communications. 7: 11756. PMID 27399229 DOI: 10.1038/Ncomms11756 |
0.39 |
|
| 2016 |
Wang YJ, Schug J, Won KJ, Liu C, Naji A, Avrahami D, Golson ML, Kaestner KH. Single cell transcriptomics of the human endocrine pancreas. Diabetes. PMID 27364731 DOI: 10.2337/Db16-0405 |
0.746 |
|
| 2016 |
Shin S, Wangensteen KJ, Teta-Bissett M, Wang YJ, Mosleh-Shirazi E, Buza EL, Greenbaum LE, Kaestner KH. Genetic Lineage Tracing Analysis of the Cell of Origin of Hepatotoxin-Induced Liver Tumors in Mice. Hepatology (Baltimore, Md.). PMID 27099001 DOI: 10.1002/Hep.28602 |
0.363 |
|
| 2016 |
Iwafuchi-Doi M, Donahue G, Kakumanu A, Watts JA, Mahony S, Pugh BF, Lee D, Kaestner KH, Zaret KS. The Pioneer Transcription Factor FoxA Maintains an Accessible Nucleosome Configuration at Enhancers for Tissue-Specific Gene Activation. Molecular Cell. 62: 79-91. PMID 27058788 DOI: 10.1016/J.Molcel.2016.03.001 |
0.376 |
|
| 2016 |
Ackermann AM, Wang Z, Schug J, Naji A, Kaestner KH. Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes. Molecular Metabolism. 5: 233-44. PMID 26977395 DOI: 10.1016/J.Molmet.2016.01.002 |
0.423 |
|
| 2016 |
Aoki R, Shoshkes-Carmel M, Gao N, Shin S, May CL, Golson ML, Zahm AM, Ray M, Wiser CL, Wright CV, Kaestner KH. Foxl1-expressing mesenchymal cells constitute the intestinal stem cell niche. Cellular and Molecular Gastroenterology and Hepatology. 2: 175-188. PMID 26949732 DOI: 10.1016/J.Jcmgh.2015.12.004 |
0.739 |
|
| 2016 |
Liu Y, Zhao Y, Skerry B, Wang X, Colin-Cassin C, Radisky DC, Kaestner KH, Li Z. Foxa1 is essential for mammary duct formation. Genesis (New York, N.Y. : 2000). PMID 26919034 DOI: 10.1002/Dvg.22929 |
0.338 |
|
| 2016 |
Sheaffer KL, Elliott EN, Kaestner KH. DNA Hypomethylation Contributes to Genomic Instability and Intestinal Cancer Initiation. Cancer Prevention Research (Philadelphia, Pa.). 9: 534-46. PMID 26883721 DOI: 10.1158/1940-6207.Capr-15-0349 |
0.318 |
|
| 2015 |
Ferreira MJ, McKenna LB, Zhang J, Reichert M, Bakir B, Buza EL, Furth EE, Bogue CW, Rustgi AK, Kaestner KH. Spontaneous Pancreatitis Caused by Tissue-Specific Gene Ablation of Hhex in Mice. Cellular and Molecular Gastroenterology and Hepatology. 1: 550-569. PMID 26740970 DOI: 10.1016/J.Jcmgh.2015.06.007 |
0.74 |
|
| 2015 |
Avrahami D, Li C, Zhang J, Schug J, Avrahami R, Rao S, Stadler MB, Burger L, Schübeler D, Glaser B, Kaestner KH. Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function. Cell Metabolism. PMID 26321660 DOI: 10.1016/J.Cmet.2015.07.025 |
0.385 |
|
| 2015 |
Elliott EN, Kaestner KH. Epigenetic regulation of the intestinal epithelium. Cellular and Molecular Life Sciences : Cmls. 72: 4139-56. PMID 26220502 DOI: 10.1007/S00018-015-1997-9 |
0.414 |
|
| 2015 |
Hernandez JB, Chang C, LeBlanc M, Grimm D, Le Lay J, Kaestner KH, Zheng Y, Montminy M. The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation. Nature Communications. 6: 7216. PMID 26031354 DOI: 10.1038/Ncomms8216 |
0.333 |
|
| 2015 |
Elliott EN, Sheaffer KL, Schug J, Stappenbeck TS, Kaestner KH. Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium. Development (Cambridge, England). 142: 2163-72. PMID 26023099 DOI: 10.1242/Dev.117341 |
0.315 |
|
| 2015 |
Wangensteen KJ, Zhang S, Greenbaum LE, Kaestner KH. A genetic screen reveals Foxa3 and TNFR1 as key regulators of liver repopulation. Genes & Development. 29: 904-9. PMID 25934503 DOI: 10.1101/Gad.258855.115 |
0.375 |
|
| 2015 |
Reddy OL, Cates JM, Gellert LL, Crist HS, Yang Z, Yamashita H, Taylor JA, Smith JA, Chang SS, Cookson MS, You C, Barocas DA, Grabowska MM, Ye F, Wu XR, ... ... Kaestner KH, et al. Loss of FOXA1 Drives Sexually Dimorphic Changes in Urothelial Differentiation and Is an Independent Predictor of Poor Prognosis in Bladder Cancer. The American Journal of Pathology. 185: 1385-95. PMID 25907831 DOI: 10.1016/J.Ajpath.2015.01.014 |
0.347 |
|
| 2015 |
Bernstein DL, Le Lay JE, Ruano EG, Kaestner KH. TALE-mediated epigenetic suppression of CDKN2A increases replication in human fibroblasts. The Journal of Clinical Investigation. 125: 1998-2006. PMID 25866970 DOI: 10.1172/Jci77321 |
0.376 |
|
| 2015 |
Kaestner KH. An epigenomic road map for endoderm development. Cell Stem Cell. 16: 343-4. PMID 25842970 DOI: 10.1016/J.Stem.2015.03.006 |
0.31 |
|
| 2015 |
Nishikawa T, Bell A, Brooks JM, Setoyama K, Melis M, Han B, Fukumitsu K, Handa K, Tian J, Kaestner KH, Vodovotz Y, Locker J, Soto-Gutierrez A, Fox IJ. Resetting the transcription factor network reverses terminal chronic hepatic failure. The Journal of Clinical Investigation. 125: 1533-44. PMID 25774505 DOI: 10.1172/Jci73137 |
0.391 |
|
| 2015 |
Blanchet E, Van de Velde S, Matsumura S, Hao E, LeLay J, Kaestner K, Montminy M. Feedback inhibition of CREB signaling promotes beta cell dysfunction in insulin resistance. Cell Reports. 10: 1149-57. PMID 25704817 DOI: 10.1016/J.Celrep.2015.01.046 |
0.413 |
|
| 2015 |
Briand LA, Lee BG, Lelay J, Kaestner KH, Blendy JA. Serine 133 phosphorylation is not required for hippocampal CREB-mediated transcription and behavior. Learning & Memory (Cold Spring Harbor, N.Y.). 22: 109-15. PMID 25593297 DOI: 10.1101/Lm.037044.114 |
0.329 |
|
| 2015 |
Jiao Y, Ye DZ, Li Z, Teta-Bissett M, Peng Y, Taub R, Greenbaum LE, Kaestner KH. Protein tyrosine phosphatase of liver regeneration-1 is required for normal timing of cell cycle progression during liver regeneration. American Journal of Physiology. Gastrointestinal and Liver Physiology. 308: G85-91. PMID 25377314 DOI: 10.1152/Ajpgi.00084.2014 |
0.393 |
|
| 2015 |
Shin S, Upadhyay N, Greenbaum LE, Kaestner KH. Ablation of Foxl1-Cre-labeled hepatic progenitor cells and their descendants impairs recovery of mice from liver injury. Gastroenterology. 148: 192-202.e3. PMID 25286440 DOI: 10.1053/J.Gastro.2014.09.039 |
0.33 |
|
| 2015 |
Galivo F, Benedetti E, Wang Y, Lee J, Schug J, Kim S, Kaestner K, Grompe M. 274. Expansion and Conversion of Patient-Derived Human Gallbladder Cells Into Insulin-Producing Pancreatic Endocrine-Like Type Cells Molecular Therapy. 23: S109-S110. DOI: 10.1016/S1525-0016(16)33883-7 |
0.421 |
|
| 2014 |
Kaestner KH. Betatrophin--promises fading and lessons learned. Cell Metabolism. 20: 932-3. PMID 25470542 DOI: 10.1016/J.Cmet.2014.11.016 |
0.337 |
|
| 2014 |
Johnson ME, Zhao J, Schug J, Deliard S, Xia Q, Guy VC, Sainz J, Kaestner KH, Wells AD, Grant SF. Two novel type 2 diabetes loci revealed through integration of TCF7L2 DNA occupancy and SNP association data. Bmj Open Diabetes Research & Care. 2: e000052. PMID 25469308 DOI: 10.1136/Bmjdrc-2014-000052 |
0.311 |
|
| 2014 |
Shin S, Le Lay J, Everett LJ, Gupta R, Rafiq K, Kaestner KH. CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells. Molecular Metabolism. 3: 803-12. PMID 25379405 DOI: 10.1016/J.Molmet.2014.08.001 |
0.68 |
|
| 2014 |
Terry NA, Walp ER, Lee RA, Kaestner KH, May CL. Impaired enteroendocrine development in intestinal-specific Islet1 mouse mutants causes impaired glucose homeostasis. American Journal of Physiology. Gastrointestinal and Liver Physiology. 307: G979-91. PMID 25214396 DOI: 10.1152/Ajpgi.00390.2013 |
0.433 |
|
| 2014 |
Dorrell C, Tarlow B, Wang Y, Canaday PS, Haft A, Schug J, Streeter PR, Finegold MJ, Shenje LT, Kaestner KH, Grompe M. The organoid-initiating cells in mouse pancreas and liver are phenotypically and functionally similar. Stem Cell Research. 13: 275-83. PMID 25151611 DOI: 10.1016/J.Scr.2014.07.006 |
0.421 |
|
| 2014 |
Choi I, Kim R, Lim HW, Kaestner KH, Won KJ. 5-hydroxymethylcytosine represses the activity of enhancers in embryonic stem cells: a new epigenetic signature for gene regulation. Bmc Genomics. 15: 670. PMID 25106691 DOI: 10.1186/1471-2164-15-670 |
0.37 |
|
| 2014 |
Patel K, Foretz M, Marion A, Campbell DG, Gourlay R, Boudaba N, Tournier E, Titchenell P, Peggie M, Deak M, Wan M, Kaestner KH, Göransson O, Viollet B, Gray NS, et al. The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver. Nature Communications. 5: 4535. PMID 25088745 DOI: 10.1038/Ncomms5535 |
0.363 |
|
| 2014 |
Golson ML, Maulis MF, Dunn JC, Poffenberger G, Schug J, Kaestner KH, Gannon MA. Activated FoxM1 attenuates streptozotocin-mediated β-cell death. Molecular Endocrinology (Baltimore, Md.). 28: 1435-47. PMID 25073103 DOI: 10.1210/Me.2014-1024 |
0.752 |
|
| 2014 |
Kameswaran V, Kaestner KH. The Missing lnc(RNA) between the pancreatic β-cell and diabetes. Frontiers in Genetics. 5: 200. PMID 25071830 DOI: 10.3389/Fgene.2014.00200 |
0.36 |
|
| 2014 |
Ediger BN, Du A, Liu J, Hunter CS, Walp ER, Schug J, Kaestner KH, Stein R, Stoffers DA, May CL. Islet-1 Is essential for pancreatic β-cell function. Diabetes. 63: 4206-17. PMID 25028525 DOI: 10.2337/Db14-0096 |
0.411 |
|
| 2014 |
Santos GJ, Ferreira SM, Ortis F, Rezende LF, Li C, Naji A, Carneiro EM, Kaestner KH, Boschero AC. Metabolic memory of ß-cells controls insulin secretion and is mediated by CaMKII. Molecular Metabolism. 3: 484-9. PMID 24944908 DOI: 10.1016/J.Molmet.2014.03.011 |
0.335 |
|
| 2014 |
Johnson ME, Schug J, Wells AD, Kaestner KH, Grant SF. Genome-wide analyses of ChIP-Seq derived FOXA2 DNA occupancy in liver points to genetic networks underpinning multiple complex traits. The Journal of Clinical Endocrinology and Metabolism. 99: E1580-5. PMID 24878043 DOI: 10.1210/Jc.2013-4503 |
0.36 |
|
| 2014 |
Zhang J, McKenna LB, Bogue CW, Kaestner KH. The diabetes gene Hhex maintains δ-cell differentiation and islet function. Genes & Development. 28: 829-34. PMID 24736842 DOI: 10.1101/Gad.235499.113 |
0.768 |
|
| 2014 |
Sheaffer KL, Kim R, Aoki R, Elliott EN, Schug J, Burger L, Schübeler D, Kaestner KH. DNA methylation is required for the control of stem cell differentiation in the small intestine Genes and Development. 28: 652-664. PMID 24637118 DOI: 10.1101/Gad.230318.113 |
0.37 |
|
| 2014 |
Lee D, Le Lay J, Kaestner KH. The transcription factor CREB has no non-redundant functions in hepatic glucose metabolism in mice. Diabetologia. 57: 1242-8. PMID 24595858 DOI: 10.1007/S00125-014-3203-2 |
0.388 |
|
| 2014 |
Seth A, Ye J, Yu N, Guez F, Bedford DC, Neale GA, Cordi S, Brindle PK, Lemaigre FP, Kaestner KH, Sosa-Pineda B. Prox1 ablation in hepatic progenitors causes defective hepatocyte specification and increases biliary cell commitment. Development (Cambridge, England). 141: 538-47. PMID 24449835 DOI: 10.1242/Dev.099481 |
0.402 |
|
| 2014 |
Shin S, Kaestner KH. The origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells. Current Topics in Developmental Biology. 107: 269-92. PMID 24439810 DOI: 10.1016/B978-0-12-416022-4.00010-X |
0.39 |
|
| 2014 |
Avrahami D, Li C, Yu M, Jiao Y, Zhang J, Naji A, Ziaie S, Glaser B, Kaestner KH. Targeting the cell cycle inhibitor p57Kip2 promotes adult human β cell replication. The Journal of Clinical Investigation. 124: 670-4. PMID 24430183 DOI: 10.1172/Jci69519 |
0.385 |
|
| 2014 |
Kameswaran V, Bramswig NC, McKenna LB, Penn M, Schug J, Hand NJ, Chen Y, Choi I, Vourekas A, Won KJ, Liu C, Vivek K, Naji A, Friedman JR, Kaestner KH. Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets. Cell Metabolism. 19: 135-45. PMID 24374217 DOI: 10.1016/J.Cmet.2013.11.016 |
0.726 |
|
| 2014 |
Bramswig NC, Kaestner KH. Transcriptional and epigenetic regulation in human islets. Diabetologia. 57: 451-4. PMID 24362728 DOI: 10.1007/S00125-013-3150-3 |
0.44 |
|
| 2014 |
Jiao Y, Le Lay J, Yu M, Naji A, Kaestner KH. Elevated mouse hepatic betatrophin expression does not increase human β-cell replication in the transplant setting. Diabetes. 63: 1283-8. PMID 24353178 DOI: 10.2337/Db13-1435 |
0.393 |
|
| 2013 |
Bochkis IM, Shin S, Kaestner KH. Bile acid-induced inflammatory signaling in mice lacking Foxa2 in the liver leads to activation of mTOR and age-onset obesity. Molecular Metabolism. 2: 447-56. PMID 24327960 DOI: 10.1016/J.Molmet.2013.08.005 |
0.774 |
|
| 2013 |
Deng Z, Glousker G, Molczan A, Fox AJ, Lamm N, Dheekollu J, Weizman OE, Schertzer M, Wang Z, Vladimirova O, Schug J, Aker M, Londoño-Vallejo A, Kaestner KH, Lieberman PM, et al. Inherited mutations in the helicase RTEL1 cause telomere dysfunction and Hoyeraal-Hreidarsson syndrome. Proceedings of the National Academy of Sciences of the United States of America. 110: E3408-16. PMID 23959892 DOI: 10.1073/Pnas.1300600110 |
0.331 |
|
| 2013 |
Jiao Y, Rieck S, Le Lay J, Kaestner KH. CISH has no non-redundant functions in glucose homeostasis or beta cell proliferation during pregnancy in mice. Diabetologia. 56: 2435-45. PMID 23949579 DOI: 10.1007/S00125-013-3014-X |
0.806 |
|
| 2013 |
Xu L, Panel V, Ma X, Du C, Hugendubler L, Gavrilova O, Liu A, McLaughlin T, Kaestner KH, Mueller E. The winged helix transcription factor Foxa3 regulates adipocyte differentiation and depot-selective fat tissue expansion. Molecular and Cellular Biology. 33: 3392-9. PMID 23798556 DOI: 10.1128/Mcb.00244-13 |
0.403 |
|
| 2013 |
Everett LJ, Le Lay J, Lukovac S, Bernstein D, Steger DJ, Lazar MA, Kaestner KH. Integrative genomic analysis of CREB defines a critical role for transcription factor networks in mediating the fed/fasted switch in liver. Bmc Genomics. 14: 337. PMID 23682854 DOI: 10.1186/1471-2164-14-337 |
0.429 |
|
| 2013 |
Stott SR, Metzakopian E, Lin W, Kaestner KH, Hen R, Ang SL. Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 8022-34. PMID 23637192 DOI: 10.1523/Jneurosci.4774-12.2013 |
0.316 |
|
| 2013 |
Schug J, McKenna LB, Walton G, Hand N, Mukherjee S, Essuman K, Shi Z, Gao Y, Markley K, Nakagawa M, Kameswaran V, Vourekas A, Friedman JR, Kaestner KH, Greenbaum LE. Dynamic recruitment of microRNAs to their mRNA targets in the regenerating liver. Bmc Genomics. 14: 264. PMID 23597149 DOI: 10.1186/1471-2164-14-264 |
0.683 |
|
| 2013 |
Hickey RD, Galivo F, Schug J, Brehm MA, Haft A, Wang Y, Benedetti E, Gu G, Magnuson MA, Shultz LD, Lagasse E, Greiner DL, Kaestner KH, Grompe M. Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming. Stem Cell Research. 11: 503-15. PMID 23562832 DOI: 10.1016/J.Scr.2013.02.005 |
0.445 |
|
| 2013 |
Bramswig NC, Everett LJ, Schug J, Dorrell C, Liu C, Luo Y, Streeter PR, Naji A, Grompe M, Kaestner KH. Epigenomic plasticity enables human pancreatic α to β cell reprogramming. The Journal of Clinical Investigation. 123: 1275-84. PMID 23434589 DOI: 10.1172/Jci66514 |
0.422 |
|
| 2013 |
Schaffer AE, Taylor BL, Benthuysen JR, Liu J, Thorel F, Yuan W, Jiao Y, Kaestner KH, Herrera PL, Magnuson MA, May CL, Sander M. Nkx6.1 controls a gene regulatory network required for establishing and maintaining pancreatic Beta cell identity. Plos Genetics. 9: e1003274. PMID 23382704 DOI: 10.1371/Journal.Pgen.1003274 |
0.426 |
|
| 2013 |
Jean JC, George E, Kaestner KH, Brown LA, Spira A, Joyce-Brady M. Transcription factor Klf4, induced in the lung by oxygen at birth, regulates perinatal fibroblast and myofibroblast differentiation. Plos One. 8: e54806. PMID 23372771 DOI: 10.1371/Journal.Pone.0054806 |
0.347 |
|
| 2013 |
Xie R, Everett LJ, Lim HW, Patel NA, Schug J, Kroon E, Kelly OG, Wang A, D'Amour KA, Robins AJ, Won KJ, Kaestner KH, Sander M. Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells. Cell Stem Cell. 12: 224-37. PMID 23318056 DOI: 10.1016/J.Stem.2012.11.023 |
0.429 |
|
| 2013 |
Lamounier RN, Coimbra CN, White P, Costal FL, Oliveira LS, Giannella-Neto D, Kaestner KH, Corrêa-Giannella ML. Apoptosis rate and transcriptional response of pancreatic islets exposed to the PPAR gamma agonist Pioglitazone. Diabetology & Metabolic Syndrome. 5: 1. PMID 23298687 DOI: 10.1186/1758-5996-5-1 |
0.355 |
|
| 2013 |
Chen K, Xi Y, Pan X, Li Z, Kaestner K, Tyler J, Dent S, He X, Li W. DANPOS: dynamic analysis of nucleosome position and occupancy by sequencing. Genome Research. 23: 341-51. PMID 23193179 DOI: 10.1101/Gr.142067.112 |
0.301 |
|
| 2013 |
Gupta A, Yu X, Case T, Paul M, Shen MM, Kaestner KH, Matusik RJ. Mash1 expression is induced in neuroendocrine prostate cancer upon the loss of Foxa2. The Prostate. 73: 582-9. PMID 23060003 DOI: 10.1002/Pros.22598 |
0.307 |
|
| 2013 |
Dorrell C, Schug J, Lin CF, Canaday PS, Fox AJ, Smirnova O, Bonnah R, Streeter PR, Stoeckert CJ, Kaestner KH, Grompe M. Erratum to: Transcriptomes of the major human pancreatic cell types Diabetologia. 56: 1192-1192. DOI: 10.1007/S00125-013-2886-0 |
0.34 |
|
| 2012 |
Li Z, Gadue P, Chen K, Jiao Y, Tuteja G, Schug J, Li W, Kaestner KH. Foxa2 and H2A.Z mediate nucleosome depletion during embryonic stem cell differentiation. Cell. 151: 1608-16. PMID 23260146 DOI: 10.1016/J.Cell.2012.11.018 |
0.711 |
|
| 2012 |
Harrelson Z, Kaestner KH, Evans SM. Foxa2 mediates critical functions of prechordal plate in patterning and morphogenesis and is cell autonomously required for early ventral endoderm morphogenesis. Biology Open. 1: 173-81. PMID 23213408 DOI: 10.1242/Bio.2012040 |
0.332 |
|
| 2012 |
Berkowitz KM, Sowash AR, Koenig LR, Urcuyo D, Khan F, Yang F, Wang PJ, Jongens TA, Kaestner KH. Disruption of CHTF18 causes defective meiotic recombination in male mice. Plos Genetics. 8: e1002996. PMID 23133398 DOI: 10.1371/Journal.Pgen.1002996 |
0.367 |
|
| 2012 |
Kaestner KH. Following the cycle: finally, a transgenic mouse to sort live replicating cells. Developmental Cell. 23: 676-7. PMID 23079592 DOI: 10.1016/J.Devcel.2012.10.006 |
0.385 |
|
| 2012 |
Sheaffer KL, Kaestner KH. Transcriptional networks in liver and intestinal development. Cold Spring Harbor Perspectives in Biology. 4: a008284. PMID 22952394 DOI: 10.1101/Cshperspect.A008284 |
0.389 |
|
| 2012 |
Rieck S, Zhang J, Li Z, Liu C, Naji A, Takane KK, Fiaschi-Taesch NM, Stewart AF, Kushner JA, Kaestner KH. Overexpression of hepatocyte nuclear factor-4α initiates cell cycle entry, but is not sufficient to promote β-cell expansion in human islets. Molecular Endocrinology (Baltimore, Md.). 26: 1590-602. PMID 22798294 DOI: 10.1210/Me.2012-1019 |
0.793 |
|
| 2012 |
Bochkis IM, Schug J, Ye DZ, Kurinna S, Stratton SA, Barton MC, Kaestner KH. Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2. Plos Genetics. 8: e1002770. PMID 22737085 DOI: 10.1371/Journal.Pgen.1002770 |
0.794 |
|
| 2012 |
Avrahami D, Kaestner KH. Epigenetic regulation of pancreas development and function. Seminars in Cell & Developmental Biology. 23: 693-700. PMID 22728076 DOI: 10.1016/J.Semcdb.2012.06.002 |
0.375 |
|
| 2012 |
Ionescu A, Kozhemyakina E, Nicolae C, Kaestner KH, Olsen BR, Lassar AB. FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program. Developmental Cell. 22: 927-39. PMID 22595668 DOI: 10.1016/J.Devcel.2012.03.011 |
0.333 |
|
| 2012 |
Bramswig NC, Kaestner KH. Epigenetics and diabetes treatment: an unrealized promise? Trends in Endocrinology and Metabolism: Tem. 23: 286-91. PMID 22424897 DOI: 10.1016/J.Tem.2012.02.002 |
0.358 |
|
| 2012 |
Khoo C, Yang J, Weinrott SA, Kaestner KH, Naji A, Schug J, Stoffers DA. Research resource: the pdx1 cistrome of pancreatic islets. Molecular Endocrinology (Baltimore, Md.). 26: 521-33. PMID 22322596 DOI: 10.1210/Me.2011-1231 |
0.453 |
|
| 2012 |
Li Z, Tuteja G, Schug J, Kaestner KH. Foxa1 and Foxa2 are essential for sexual dimorphism in liver cancer. Cell. 148: 72-83. PMID 22265403 DOI: 10.1016/J.Cell.2011.11.026 |
0.67 |
|
| 2012 |
Bramswig NC, Kaestner KH. Organogenesis and functional genomics of the endocrine pancreas. Cellular and Molecular Life Sciences : Cmls. 69: 2109-23. PMID 22241333 DOI: 10.1007/S00018-011-0915-Z |
0.427 |
|
| 2012 |
Cui CY, Childress V, Piao Y, Michel M, Johnson AA, Kunisada M, Ko MS, Kaestner KH, Marmorstein AD, Schlessinger D. Forkhead transcription factor FoxA1 regulates sweat secretion through Bestrophin 2 anion channel and Na-K-Cl cotransporter 1. Proceedings of the National Academy of Sciences of the United States of America. 109: 1199-203. PMID 22223659 DOI: 10.1073/Pnas.1117213109 |
0.326 |
|
| 2012 |
Liu L, Yannam GR, Nishikawa T, Yamamoto T, Basma H, Ito R, Nagaya M, Dutta-Moscato J, Stolz DB, Duan F, Kaestner KH, Vodovotz Y, Soto-Gutierrez A, Fox IJ. The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis. Hepatology (Baltimore, Md.). 55: 1529-39. PMID 22109844 DOI: 10.1002/Hep.24815 |
0.369 |
|
| 2012 |
Hald J, Galbo T, Rescan C, Radzikowski L, Sprinkel AE, Heimberg H, Ahnfelt-Rønne J, Jensen J, Scharfmann R, Gradwohl G, Kaestner KH, Stoeckert C, Jensen JN, Madsen OD. Pancreatic islet and progenitor cell surface markers with cell sorting potential. Diabetologia. 55: 154-65. PMID 21947380 DOI: 10.1007/S00125-011-2295-1 |
0.35 |
|
| 2012 |
Li Z, Tuteja G, Schug J, Kaestner KH. Abstract 5112: Foxa1 and Foxa2 are essential for gender dimorphism in liver cancer Cancer Research. 72: 5112-5112. DOI: 10.1158/1538-7445.Am2012-5112 |
0.661 |
|
| 2011 |
Friedman JR, Kaestner KH. On the origin of the liver. The Journal of Clinical Investigation. 121: 4630-3. PMID 22105167 DOI: 10.1172/Jci59652 |
0.323 |
|
| 2011 |
Wan M, Leavens KF, Saleh D, Easton RM, Guertin DA, Peterson TR, Kaestner KH, Sabatini DM, Birnbaum MJ. Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c. Cell Metabolism. 14: 516-27. PMID 21982711 DOI: 10.1016/J.Cmet.2011.09.001 |
0.371 |
|
| 2011 |
Dorrell C, Schug J, Lin CF, Canaday PS, Fox AJ, Smirnova O, Bonnah R, Streeter PR, Stoeckert CJ, Kaestner KH, Grompe M. Transcriptomes of the major human pancreatic cell types Diabetologia. 54: 2832-2844. PMID 21882062 DOI: 10.1007/S00125-011-2283-5 |
0.427 |
|
| 2011 |
Bramswig NC, Kaestner KH. Transcriptional regulation of α-cell differentiation Diabetes, Obesity and Metabolism. 13: 13-20. PMID 21824252 DOI: 10.1111/J.1463-1326.2011.01440.X |
0.408 |
|
| 2011 |
Dorrell C, Erker L, Schug J, Kopp JL, Canaday PS, Fox AJ, Smirnova O, Duncan AW, Finegold MJ, Sander M, Kaestner KH, Grompe M. Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice. Genes & Development. 25: 1193-203. PMID 21632826 DOI: 10.1101/Gad.2029411 |
0.404 |
|
| 2011 |
Shin S, Walton G, Aoki R, Brondell K, Schug J, Fox A, Smirnova O, Dorrell C, Erker L, Chu AS, Wells RG, Grompe M, Greenbaum LE, Kaestner KH. Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential. Genes & Development. 25: 1185-92. PMID 21632825 DOI: 10.1101/Gad.2027811 |
0.405 |
|
| 2011 |
Li Z, Schug J, Tuteja G, White P, Kaestner KH. The nucleosome map of the mammalian liver. Nature Structural & Molecular Biology. 18: 742-6. PMID 21623366 DOI: 10.1038/Nsmb.2060 |
0.716 |
|
| 2011 |
Miller RA, Chu Q, Le Lay J, Scherer PE, Ahima RS, Kaestner KH, Foretz M, Viollet B, Birnbaum MJ. Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling. The Journal of Clinical Investigation. 121: 2518-28. PMID 21606593 DOI: 10.1172/Jci45942 |
0.387 |
|
| 2011 |
Matschinsky FM, Zelent B, Doliba NM, Kaestner KH, Vanderkooi JM, Grimsby J, Berthel SJ, Sarabu R. Research and development of glucokinase activators for diabetes therapy: theoretical and practical aspects. Handbook of Experimental Pharmacology. 357-401. PMID 21484579 DOI: 10.1007/978-3-642-17214-4_15 |
0.349 |
|
| 2011 |
Porat S, Weinberg-Corem N, Tornovsky-Babaey S, Schyr-Ben-Haroush R, Hija A, Stolovich-Rain M, Dadon D, Granot Z, Ben-Hur V, White P, Girard CA, Karni R, Kaestner KH, Ashcroft FM, Magnuson MA, et al. Control of pancreatic β cell regeneration by glucose metabolism. Cell Metabolism. 13: 440-9. PMID 21459328 DOI: 10.1016/J.Cmet.2011.02.012 |
0.391 |
|
| 2011 |
Maloum F, Allaire JM, Gagné-Sansfaçon J, Roy E, Belleville K, Sarret P, Morisset J, Carrier JC, Mishina Y, Kaestner KH, Perreault N. Epithelial BMP signaling is required for proper specification of epithelial cell lineages and gastric endocrine cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 300: G1065-79. PMID 21415412 DOI: 10.1152/Ajpgi.00176.2010 |
0.358 |
|
| 2011 |
Hill JT, Anderson KR, Mastracci TL, Kaestner KH, Sussel L. Novel computational analysis of protein binding array data identifies direct targets of Nkx2.2 in the pancreas. Bmc Bioinformatics. 12: 62. PMID 21352540 DOI: 10.1186/1471-2105-12-62 |
0.301 |
|
| 2011 |
Gao N, Davuluri G, Gong W, Seiler C, Lorent K, Furth EE, Kaestner KH, Pack M. The nuclear pore complex protein Elys is required for genome stability in mouse intestinal epithelial progenitor cells. Gastroenterology. 140: 1547-55.e10. PMID 21315719 DOI: 10.1053/J.Gastro.2011.01.048 |
0.325 |
|
| 2011 |
Soccio RE, Tuteja G, Everett LJ, Li Z, Lazar MA, Kaestner KH. Species-specific strategies underlying conserved functions of metabolic transcription factors. Molecular Endocrinology (Baltimore, Md.). 25: 694-706. PMID 21292830 DOI: 10.1210/Me.2010-0454 |
0.705 |
|
| 2011 |
Pellegrinet L, Rodilla V, Liu Z, Chen S, Koch U, Espinosa L, Kaestner KH, Kopan R, Lewis J, Radtke F. Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology. 140: 1230-1240.e1-7. PMID 21238454 DOI: 10.1053/J.Gastro.2011.01.005 |
0.412 |
|
| 2011 |
Jeong Y, Dolson DK, Waclaw RR, Matise MP, Sussel L, Campbell K, Kaestner KH, Epstein DJ. Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity. Development (Cambridge, England). 138: 531-41. PMID 21205797 DOI: 10.1242/Dev.058917 |
0.311 |
|
| 2011 |
Ghaleb AM, McConnell BB, Kaestner KH, Yang VW. Altered intestinal epithelial homeostasis in mice with intestine-specific deletion of the Krüppel-like factor 4 gene. Developmental Biology. 349: 310-20. PMID 21070761 DOI: 10.1016/J.Ydbio.2010.11.001 |
0.443 |
|
| 2011 |
Gao Y, Schug J, McKenna LB, Le Lay J, Kaestner KH, Greenbaum LE. Tissue-specific regulation of mouse microRNA genes in endoderm-derived tissues. Nucleic Acids Research. 39: 454-63. PMID 20843784 DOI: 10.1093/Nar/Gkq782 |
0.733 |
|
| 2011 |
Lukovac S, Lee D, Pack MA, Kaestner KH. RNA Polymerase III is Required for Intestinal Epithelial Development and Paneth Cell Maturation in Mice Gastroenterology. 140. DOI: 10.1016/S0016-5085(11)60336-3 |
0.375 |
|
| 2010 |
Haeusler RA, Kaestner KH, Accili D. FoxOs function synergistically to promote glucose production. The Journal of Biological Chemistry. 285: 35245-8. PMID 20880840 DOI: 10.1074/Jbc.C110.175851 |
0.382 |
|
| 2010 |
McKenna LB, Schug J, Vourekas A, McKenna JB, Bramswig NC, Friedman JR, Kaestner KH. MicroRNAs control intestinal epithelial differentiation, architecture, and barrier function. Gastroenterology. 139: 1654-64, 1664.e1. PMID 20659473 DOI: 10.1053/J.Gastro.2010.07.040 |
0.683 |
|
| 2010 |
Zhao J, Schug J, Li M, Kaestner KH, Grant SFA. Disease-associated loci are significantly over-represented among genes bound by transcription factor 7-like 2 (TCF7L2) in vivo Diabetologia. 53: 2340-2346. PMID 20640398 DOI: 10.1007/S00125-010-1852-3 |
0.379 |
|
| 2010 |
Kaestner KH. The FoxA factors in organogenesis and differentiation. Current Opinion in Genetics & Development. 20: 527-32. PMID 20591647 DOI: 10.1016/J.Gde.2010.06.005 |
0.374 |
|
| 2010 |
Gao N, Kaestner KH. Cdx2 regulates endo-lysosomal function and epithelial cell polarity Genes and Development. 24: 1295-1305. PMID 20551175 DOI: 10.1101/Gad.1921510 |
0.381 |
|
| 2010 |
Gao N, Le Lay J, Qin W, Doliba N, Schug J, Fox AJ, Smirnova O, Matschinsky FM, Kaestner KH. Foxa1 and Foxa2 maintain the metabolic and secretory features of the mature beta-cell. Molecular Endocrinology (Baltimore, Md.). 24: 1594-604. PMID 20534694 DOI: 10.1210/Me.2009-0513 |
0.43 |
|
| 2010 |
Bernardo GM, Lozada KL, Miedler JD, Harburg G, Hewitt SC, Mosley JD, Godwin AK, Korach KS, Visvader JE, Kaestner KH, Abdul-Karim FW, Montano MM, Keri RA. FOXA1 is an essential determinant of ERalpha expression and mammary ductal morphogenesis. Development (Cambridge, England). 137: 2045-54. PMID 20501593 DOI: 10.1242/Dev.043299 |
0.326 |
|
| 2010 |
Jeong JW, Kwak I, Lee KY, Kim TH, Large MJ, Stewart CL, Kaestner KH, Lydon JP, DeMayo FJ. Foxa2 is essential for mouse endometrial gland development and fertility. Biology of Reproduction. 83: 396-403. PMID 20484741 DOI: 10.1095/Biolreprod.109.083154 |
0.354 |
|
| 2010 |
Kaestner KH. From embryonic stem cells to beta-cells: new hope for diabetics? Gastroenterology. 138: 2211-2. PMID 20435010 DOI: 10.1053/J.Gastro.2010.04.026 |
0.338 |
|
| 2010 |
Liao X, Haldar SM, Lu Y, Jeyaraj D, Paruchuri K, Nahori M, Cui Y, Kaestner KH, Jain MK. Krüppel-like factor 4 regulates pressure-induced cardiac hypertrophy. Journal of Molecular and Cellular Cardiology. 49: 334-8. PMID 20433848 DOI: 10.1016/J.Yjmcc.2010.04.008 |
0.352 |
|
| 2010 |
Gu C, Stein GH, Pan N, Goebbels S, Hörnberg H, Nave KA, Herrera P, White P, Kaestner KH, Sussel L, Lee JE. Pancreatic beta cells require NeuroD to achieve and maintain functional maturity. Cell Metabolism. 11: 298-310. PMID 20374962 DOI: 10.1016/J.Cmet.2010.03.006 |
0.411 |
|
| 2010 |
Sakamoto K, Hikiba Y, Nakagawa H, Hayakawa Y, Yanai A, Akanuma M, Ogura K, Hirata Y, Kaestner KH, Omata M, Maeda S. Inhibitor of kappaB kinase beta regulates gastric carcinogenesis via interleukin-1alpha expression. Gastroenterology. 139: 226-38.e6. PMID 20347815 DOI: 10.1053/J.Gastro.2010.03.047 |
0.308 |
|
| 2010 |
Bhandare R, Schug J, Le Lay J, Fox A, Smirnova O, Liu C, Naji A, Kaestner KH. Genome-wide analysis of histone modifications in human pancreatic islets. Genome Research. 20: 428-33. PMID 20181961 DOI: 10.1101/Gr.102038.109 |
0.367 |
|
| 2010 |
Kaestner KH. Making the liver what it is: the many targets of the transcriptional regulator HNF4alpha. Hepatology (Baltimore, Md.). 51: 376-7. PMID 20101744 DOI: 10.1002/Hep.23487 |
0.353 |
|
| 2010 |
Le Lay J, Kaestner KH. The Fox genes in the liver: from organogenesis to functional integration. Physiological Reviews. 90: 1-22. PMID 20086072 DOI: 10.1152/Physrev.00018.2009 |
0.389 |
|
| 2010 |
May CL, Kaestner KH. Gut endocrine cell development. Molecular and Cellular Endocrinology. 323: 70-5. PMID 20025933 DOI: 10.1016/J.Mce.2009.12.009 |
0.398 |
|
| 2010 |
Rieck S, Kaestner KH. Expansion of beta-cell mass in response to pregnancy. Trends in Endocrinology and Metabolism: Tem. 21: 151-8. PMID 20015659 DOI: 10.1016/J.Tem.2009.11.001 |
0.791 |
|
| 2010 |
Shibata W, Takaishi S, Muthupalani S, Pritchard DM, Whary MT, Rogers AB, Fox JG, Betz KS, Kaestner KH, Karin M, Wang TC. Conditional deletion of IkappaB-kinase-beta accelerates helicobacter-dependent gastric apoptosis, proliferation, and preneoplasia. Gastroenterology. 138: 1022-34.e1-10. PMID 19962981 DOI: 10.1053/J.Gastro.2009.11.054 |
0.335 |
|
| 2010 |
Gleason CE, Ning Y, Cominski TP, Gupta R, Kaestner KH, Pintar JE, Birnbaum MJ. Role of insulin-like growth factor-binding protein 5 (IGFBP5) in organismal and pancreatic beta-cell growth. Molecular Endocrinology (Baltimore, Md.). 24: 178-92. PMID 19897600 DOI: 10.1210/Me.2009-0167 |
0.682 |
|
| 2010 |
Gao N, Le Lay J, Qin W, Doliba N, Schug J, Fox AJ, Smirnova O, Matschinsky FM, Kaestner KH. Foxa1 and Foxa2 Maintain the Metabolic and Secretory Features of the Mature β-Cell The Journal of Clinical Endocrinology & Metabolism. 95: 3564-3564. DOI: 10.1210/Jcem.95.7.9996 |
0.301 |
|
| 2010 |
Ghaleb A, McConnell BB, Katz JP, Kaestner KH, Yang VW. 558 Intestine-Specific Deletion of the Mouse KrüPpel-Like Factor 4 Gene Results in Altered Homeostasis of Intestinal Epithelial Cells Gastroenterology. 138: S-78. DOI: 10.1016/S0016-5085(10)60353-8 |
0.41 |
|
| 2009 |
Gleason CE, Ning Y, Cominski TP, Gupta R, Kaestner KH, Pintar JE, Birnbaum MJ. Role of Insulin-Like Growth Factor-Binding Protein 5 (IGFBP5) in Organismal and Pancreatic β-Cell Growth. Endocrine Reviews. 30: 930. PMID 28199555 DOI: 10.1210/Edrv.30.7.9990 |
0.652 |
|
| 2009 |
Anderson KR, White P, Kaestner KH, Sussel L. Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development. Bmc Developmental Biology. 9: 65. PMID 20003319 DOI: 10.1186/1471-213X-9-65 |
0.497 |
|
| 2009 |
Sackett SD, Gao Y, Shin S, Esterson YB, Tsingalia A, Hurtt RS, Brondell K, Kaestner KH, Greenbaum LE. Foxl1 promotes liver repair following cholestatic injury in mice. Laboratory Investigation; a Journal of Technical Methods and Pathology. 89: 1387-96. PMID 19841618 DOI: 10.1038/Labinvest.2009.103 |
0.738 |
|
| 2009 |
Hinoi E, Gao N, Jung DY, Yadav V, Yoshizawa T, Kajimura D, Myers MG, Chua SC, Wang Q, Kim JK, Kaestner KH, Karsenty G. An Osteoblast-dependent mechanism contributes to the leptin regulation of insulin secretion. Annals of the New York Academy of Sciences. 1173: E20-30. PMID 19751411 DOI: 10.1111/J.1749-6632.2009.05061.X |
0.384 |
|
| 2009 |
Ye DZ, Kaestner KH. Foxa1 and Foxa2 Control the Differentiation of Goblet and Enteroendocrine L- and D-Cells in Mice Gastroenterology. 137: 2052-2062. PMID 19737569 DOI: 10.1053/J.Gastro.2009.08.059 |
0.409 |
|
| 2009 |
Spence JR, Lange AW, Lin SC, Kaestner KH, Lowy AM, Kim I, Whitsett JA, Wells JM. Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Developmental Cell. 17: 62-74. PMID 19619492 DOI: 10.1016/J.Devcel.2009.05.012 |
0.412 |
|
| 2009 |
Lin W, Metzakopian E, Mavromatakis YE, Gao N, Balaskas N, Sasaki H, Briscoe J, Whitsett JA, Goulding M, Kaestner KH, Ang SL. Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development. Developmental Biology. 333: 386-96. PMID 19607821 DOI: 10.1016/J.Ydbio.2009.07.006 |
0.329 |
|
| 2009 |
Le Lay J, Tuteja G, White P, Dhir R, Ahima R, Kaestner KH. CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis. Cell Metabolism. 10: 55-62. PMID 19583954 DOI: 10.1016/J.Cmet.2009.06.006 |
0.722 |
|
| 2009 |
Rieck S, White P, Schug J, Fox AJ, Smirnova O, Gao N, Gupta RK, Wang ZV, Scherer PE, Keller MP, Attie AD, Kaestner KH. The transcriptional response of the islet to pregnancy in mice. Molecular Endocrinology (Baltimore, Md.). 23: 1702-12. PMID 19574445 DOI: 10.1210/Me.2009-0144 |
0.803 |
|
| 2009 |
Zheng K, Wu X, Kaestner KH, Wang PJ. The pluripotency factor LIN28 marks undifferentiated spermatogonia in mouse. Bmc Developmental Biology. 9: 38. PMID 19563657 DOI: 10.1186/1471-213X-9-38 |
0.328 |
|
| 2009 |
Tuteja G, White P, Schug J, Kaestner KH. Extracting transcription factor targets from ChIP-Seq data. Nucleic Acids Research. 37: e113. PMID 19553195 DOI: 10.1093/Nar/Gkp536 |
0.672 |
|
| 2009 |
Godmann M, Gashaw I, Katz JP, Nagy A, Kaestner KH, Behr R. Krüppel-like factor 4, a "pluripotency transcription factor" highly expressed in male postmeiotic germ cells, is dispensable for spermatogenesis in the mouse. Mechanisms of Development. 126: 650-664. PMID 19539755 DOI: 10.1016/J.Mod.2009.06.1081 |
0.463 |
|
| 2009 |
White P, Kaestner KH. Gene expression analysis in diabetes research. Methods of Molecular Biology. 560: 239-261. PMID 19504254 DOI: 10.1007/978-1-59745-448-3_16 |
0.315 |
|
| 2009 |
Golson ML, Le Lay J, Gao N, Brämswig N, Loomes KM, Oakey R, May CL, White P, Kaestner KH. Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas. Mechanisms of Development. 126: 687-99. PMID 19501159 DOI: 10.1016/J.Mod.2009.05.005 |
0.754 |
|
| 2009 |
Oliver-Krasinski JM, Kasner MT, Yang J, Crutchlow MF, Rustgi AK, Kaestner KH, Stoffers DA. The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice. The Journal of Clinical Investigation. 119: 1888-98. PMID 19487809 DOI: 10.1172/Jci37028 |
0.483 |
|
| 2009 |
Li Z, White P, Tuteja G, Rubins N, Sackett S, Kaestner KH. Foxa1 and Foxa2 regulate bile duct development in mice. The Journal of Clinical Investigation. 119: 1537-45. PMID 19436110 DOI: 10.1172/Jci38201 |
0.793 |
|
| 2009 |
Bochkis IM, Schug J, Rubins NE, Chopra AR, O'Malley BW, Kaestner KH. Foxa2-dependent hepatic gene regulatory networks depend on physiological state. Physiological Genomics. 38: 186-95. PMID 19417011 DOI: 10.1152/Physiolgenomics.90376.2008 |
0.789 |
|
| 2009 |
Gao N, White P, Kaestner KH. Establishment of intestinal identity and epithelial-mesenchymal signaling by Cdx2. Developmental Cell. 16: 588-99. PMID 19386267 DOI: 10.1016/J.Devcel.2009.02.010 |
0.398 |
|
| 2009 |
Hannenhalli S, Kaestner KH. The evolution of Fox genes and their role in development and disease. Nature Reviews. Genetics. 10: 233-40. PMID 19274050 DOI: 10.1038/Nrg2523 |
0.333 |
|
| 2009 |
Golson ML, Loomes KM, Oakey R, Kaestner KH. Ductal malformation and pancreatitis in mice caused by conditional Jag1 deletion. Gastroenterology. 136: 1761-71.e1. PMID 19208348 DOI: 10.1053/J.Gastro.2009.01.040 |
0.716 |
|
| 2009 |
Sackett SD, Li Z, Hurtt R, Gao Y, Wells RG, Brondell K, Kaestner KH, Greenbaum LE. Foxl1 is a marker of bipotential hepatic progenitor cells in mice. Hepatology (Baltimore, Md.). 49: 920-9. PMID 19105206 DOI: 10.1002/Hep.22705 |
0.764 |
|
| 2009 |
Li L, Oropeza CE, Kaestner KH, McLachlan A. Limited effects of fasting on hepatitis B virus (HBV) biosynthesis in HBV transgenic mice. Journal of Virology. 83: 1682-8. PMID 19073739 DOI: 10.1128/Jvi.02208-08 |
0.317 |
|
| 2009 |
Madison BB, McKenna LB, Dolson D, Epstein DJ, Kaestner KH. FoxF1 and FoxL1 link hedgehog signaling and the control of epithelial proliferation in the developing stomach and intestine. The Journal of Biological Chemistry. 284: 5936-44. PMID 19049965 DOI: 10.1074/Jbc.M808103200 |
0.721 |
|
| 2009 |
McKenna L, Kaestner KH, Schug J. 395 The Role of MicroRNAs in the Intestinal Epithelium Gastroenterology. 136: A-66. DOI: 10.1016/S0016-5085(09)60298-5 |
0.688 |
|
| 2008 |
Gao N, LeLay J, Vatamaniuk MZ, Rieck S, Friedman JR, Kaestner KH. Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development. Genes & Development. 22: 3435-48. PMID 19141476 DOI: 10.1101/Gad.1752608 |
0.819 |
|
| 2008 |
Hinoi E, Gao N, Jung DY, Yadav V, Yoshizawa T, Myers MG, Chua SC, Kim JK, Kaestner KH, Karsenty G. The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. The Journal of Cell Biology. 183: 1235-42. PMID 19103808 DOI: 10.1083/Jcb.200809113 |
0.336 |
|
| 2008 |
Kaestner KH. A two-step pathway to resist fasting. Cell Metabolism. 8: 449-451. PMID 19041759 DOI: 10.1016/J.Cmet.2008.11.003 |
0.31 |
|
| 2008 |
Alenghat T, Meyers K, Mullican SE, Leitner K, Adeniji-Adele A, Avila J, Bućan M, Ahima RS, Kaestner KH, Lazar MA. Nuclear receptor corepressor and histone deacetylase 3 govern circadian metabolic physiology. Nature. 456: 997-1000. PMID 19037247 DOI: 10.1038/Nature07541 |
0.361 |
|
| 2008 |
Gkretsi V, Apte U, Mars WM, Bowen WC, Luo JH, Yang Y, Yu YP, Orr A, St-Arnaud R, Dedhar S, Kaestner KH, Wu C, Michalopoulos GK. Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly. Hepatology (Baltimore, Md.). 48: 1932-41. PMID 18846549 DOI: 10.1002/Hep.22537 |
0.426 |
|
| 2008 |
Bochkis IM, Rubins NE, White P, Furth EE, Friedman JR, Kaestner KH. Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress. Nature Medicine. 14: 828-36. PMID 18660816 DOI: 10.1038/Nm.1853 |
0.785 |
|
| 2008 |
Mullany LK, White P, Hanse EA, Nelsen CJ, Goggin MM, Mullany JE, Anttila CK, Greenbaum LE, Kaestner KH, Albrecht JH. Distinct proliferative and transcriptional effects of the D-type cyclins in vivo. Cell Cycle (Georgetown, Tex.). 7: 2215-24. PMID 18635970 DOI: 10.4161/Cc.7.14.6274 |
0.301 |
|
| 2008 |
Tuteja G, Jensen ST, White P, Kaestner KH. Cis-regulatory modules in the mammalian liver: composition depends on strength of Foxa2 consensus site. Nucleic Acids Research. 36: 4149-57. PMID 18556755 DOI: 10.1093/Nar/Gkn366 |
0.708 |
|
| 2008 |
Yoshida T, Kaestner KH, Owens GK. Conditional deletion of Krüppel-like factor 4 delays downregulation of smooth muscle cell differentiation markers but accelerates neointimal formation following vascular injury. Circulation Research. 102: 1548-57. PMID 18483411 DOI: 10.1161/Circresaha.108.176974 |
0.358 |
|
| 2008 |
Tan X, Yuan Y, Zeng G, Apte U, Thompson MD, Cieply B, Stolz DB, Michalopoulos GK, Kaestner KH, Monga SP. Beta-catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development. Hepatology (Baltimore, Md.). 47: 1667-79. PMID 18393386 DOI: 10.1002/Hep.22225 |
0.408 |
|
| 2008 |
Yusuf I, Kharas MG, Chen J, Peralta RQ, Maruniak A, Sareen P, Yang VW, Kaestner KH, Fruman DA. KLF4 is a FOXO target gene that suppresses B cell proliferation. International Immunology. 20: 671-81. PMID 18375530 DOI: 10.1093/Intimm/Dxn024 |
0.405 |
|
| 2008 |
Berkowitz KM, Kaestner KH, Jongens TA. Germline expression of mammalian CTF18, an evolutionarily conserved protein required for germ cell proliferation in the fly and sister chromatid cohesion in yeast. Molecular Human Reproduction. 14: 143-50. PMID 18250106 DOI: 10.1093/Molehr/Gan005 |
0.388 |
|
| 2008 |
Godmann M, Katz JP, Guillou F, Simoni M, Kaestner KH, Behr R. Krüppel-like factor 4 is involved in functional differentiation of testicular Sertoli cells. Developmental Biology. 315: 552-566. PMID 18243172 DOI: 10.1016/J.Ydbio.2007.12.018 |
0.463 |
|
| 2008 |
White P, May CL, Lamounier RN, Brestelli JE, Kaestner KH. Defining pancreatic endocrine precursors and their descendants. Diabetes. 57: 654-68. PMID 18071024 DOI: 10.2337/Db07-1362 |
0.404 |
|
| 2007 |
Tuteja G, Kaestner KH. Forkhead transcription factors II. Cell. 131: 192. PMID 17923097 DOI: 10.1016/J.Cell.2007.09.016 |
0.665 |
|
| 2007 |
Gao N, White P, Doliba N, Golson ML, Matschinsky FM, Kaestner KH. Foxa2 controls vesicle docking and insulin secretion in mature Beta cells. Cell Metabolism. 6: 267-79. PMID 17908556 DOI: 10.1016/J.Cmet.2007.08.015 |
0.761 |
|
| 2007 |
Tuteja G, Kaestner KH. SnapShot: forkhead transcription factors I. Cell. 130: 1160. PMID 17889656 DOI: 10.1016/J.Cell.2007.09.005 |
0.682 |
|
| 2007 |
Klaewsongkram J, Yang Y, Golech S, Katz J, Kaestner KH, Weng N. Krüppel-like factor 4 regulates B cell number and activation-induced B cell proliferation. Journal of Immunology. 179: 4679-4684. PMID 17878366 DOI: 10.4049/Jimmunol.179.7.4679 |
0.369 |
|
| 2007 |
Kaestner KH. β Cell transplantation and immunosuppression: can’t live with it, can’t live without it Journal of Clinical Investigation. 117: 2380-2382. PMID 17786232 DOI: 10.1172/Jci33375 |
0.355 |
|
| 2007 |
Feinberg MW, Wara AK, Cao Z, Lebedeva MA, Rosenbauer F, Iwasaki H, Hirai H, Katz JP, Haspel RL, Gray S, Akashi K, Segre J, Kaestner KH, Tenen DG, Jain MK. The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation. The Embo Journal. 26: 4138-48. PMID 17762869 DOI: 10.1038/Sj.Emboj.7601824 |
0.412 |
|
| 2007 |
Keller DM, McWeeney S, Arsenlis A, Drouin J, Wright CV, Wang H, Wollheim CB, White P, Kaestner KH, Goodman RH. Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy. The Journal of Biological Chemistry. 282: 32084-92. PMID 17761679 DOI: 10.1074/Jbc.M700899200 |
0.447 |
|
| 2007 |
Ghaleb AM, McConnell BB, Nandan MO, Katz JP, Kaestner KH, Yang VW. Haploinsufficiency of Krüppel-like factor 4 promotes adenomatous polyposis coli dependent intestinal tumorigenesis. Cancer Research. 67: 7147-54. PMID 17671182 DOI: 10.1158/0008-5472.Can-07-1302 |
0.368 |
|
| 2007 |
Sackett SD, Fulmer JT, Friedman JR, Kaestner KH. Foxl1-Cre BAC transgenic mice: a new tool for gene ablation in the gastrointestinal mesenchyme. Genesis (New York, N.Y. : 2000). 45: 518-22. PMID 17661401 DOI: 10.1002/Dvg.20315 |
0.737 |
|
| 2007 |
Hunter MP, Wilson CM, Jiang X, Cong R, Vasavada H, Kaestner KH, Bogue CW. The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis. Developmental Biology. 308: 355-67. PMID 17580084 DOI: 10.1016/J.Ydbio.2007.05.028 |
0.403 |
|
| 2007 |
Behr R, Sackett SD, Bochkis IM, Le PP, Kaestner KH. Impaired male fertility and atrophy of seminiferous tubules caused by haploinsufficiency for Foxa3. Developmental Biology. 306: 636-45. PMID 17488644 DOI: 10.1016/J.Ydbio.2007.03.525 |
0.822 |
|
| 2007 |
Gupta RK, Gao N, Gorski RK, White P, Hardy OT, Rafiq K, Brestelli JE, Chen G, Stoeckert CJ, Kaestner KH. Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha. Genes & Development. 21: 756-69. PMID 17403778 DOI: 10.1101/Gad.1535507 |
0.665 |
|
| 2007 |
Ku HT, Chai J, Kim Y, White P, Purohit-Ghelani S, Kaestner KH, Bromberg JS. Insulin-Expressing Colonies Developed From Murine Embryonic Stem Cell–Derived Progenitors Diabetes. 56: 921-929. PMID 17395739 DOI: 10.2337/Db06-0468 |
0.388 |
|
| 2007 |
Loomes KM, Russo P, Ryan M, Nelson A, Underkoffler L, Glover C, Fu H, Gridley T, Kaestner KH, Oakey RJ. Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage. Hepatology (Baltimore, Md.). 45: 323-30. PMID 17366661 DOI: 10.1002/Hep.21460 |
0.402 |
|
| 2007 |
Apte U, Zeng G, Thompson MD, Muller P, Micsenyi A, Cieply B, Kaestner KH, Monga SP. beta-Catenin is critical for early postnatal liver growth. American Journal of Physiology. Gastrointestinal and Liver Physiology. 292: G1578-85. PMID 17332475 DOI: 10.1152/Ajpgi.00359.2006 |
0.327 |
|
| 2007 |
Hardy OT, Hohmeier HE, Becker TC, Manduchi E, Doliba NM, Gupta RK, White P, Stoeckert CJ, Matschinsky FM, Newgard CB, Kaestner KH. Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents. Molecular Endocrinology (Baltimore, Md.). 21: 765-73. PMID 17185391 DOI: 10.1210/Me.2006-0411 |
0.679 |
|
| 2007 |
Mazzarelli JM, Brestelli J, Gorski RK, Liu J, Manduchi E, Pinney DF, Schug J, White P, Kaestner KH, Stoeckert CJ. EPConDB: a web resource for gene expression related to pancreatic development, beta-cell function and diabetes. Nucleic Acids Research. 35: D751-5. PMID 17071715 DOI: 10.1093/Nar/Gkl748 |
0.448 |
|
| 2007 |
Swamynathan SK, Katz JP, Kaestner KH, Ashery-Padan R, Crawford MA, Piatigorsky J. Conditional deletion of the mouse Klf4 gene results in corneal epithelial fragility, stromal edema, and loss of conjunctival goblet cells. Molecular and Cellular Biology. 27: 182-94. PMID 17060454 DOI: 10.1128/Mcb.00846-06 |
0.397 |
|
| 2006 |
Ghaleb AM, Katz JP, Kaestner KH, Du JX, Yang VW. Krüppel-like factor 4 exhibits antiapoptotic activity following gamma-radiation-induced DNA damage. Oncogene. 26: 2365-73. PMID 17016435 DOI: 10.1038/Sj.Onc.1210022 |
0.361 |
|
| 2006 |
Apte U, Zeng G, Muller P, Tan X, Micsenyi A, Cieply B, Dai C, Liu Y, Kaestner KH, Monga SP. Activation of Wnt/beta-catenin pathway during hepatocyte growth factor-induced hepatomegaly in mice. Hepatology (Baltimore, Md.). 44: 992-1002. PMID 17006939 DOI: 10.1002/Hep.21317 |
0.35 |
|
| 2006 |
Vatamaniuk MZ, Gupta RK, Lantz KA, Doliba NM, Matschinsky FM, Kaestner KH. Foxa1-deficient mice exhibit impaired insulin secretion due to uncoupled oxidative phosphorylation. Diabetes. 55: 2730-6. PMID 17003337 DOI: 10.2337/Db05-0470 |
0.796 |
|
| 2006 |
Calmont A, Wandzioch E, Tremblay KD, Minowada G, Kaestner KH, Martin GR, Zaret KS. An FGF response pathway that mediates hepatic gene induction in embryonic endoderm cells. Developmental Cell. 11: 339-48. PMID 16950125 DOI: 10.1016/J.Devcel.2006.06.015 |
0.382 |
|
| 2006 |
Friedman JR, Kaestner KH. The Foxa family of transcription factors in development and metabolism. Cellular and Molecular Life Sciences : Cmls. 63: 2317-28. PMID 16909212 DOI: 10.1007/S00018-006-6095-6 |
0.399 |
|
| 2006 |
Zelent D, Golson ML, Koeberlein B, Quintens R, van Lommel L, Buettger C, Weik-Collins H, Taub R, Grimsby J, Schuit F, Kaestner KH, Matschinsky FM. A glucose sensor role for glucokinase in anterior pituitary cells. Diabetes. 55: 1923-9. PMID 16804059 DOI: 10.2337/Db06-0151 |
0.749 |
|
| 2006 |
Mazzarelli JM, White P, Gorski R, Brestelli J, Pinney DF, Arsenlis A, Katokhin A, Belova O, Bogdanova V, Elisafenko E, Gubina M, Nizolenko L, Perelman P, Puzakov M, Shilov A, ... ... Kaestner KH, et al. Novel genes identified by manual annotation and microarray expression analysis in the pancreas Genomics. 88: 752-761. PMID 16725306 DOI: 10.1016/J.Ygeno.2006.04.005 |
0.404 |
|
| 2006 |
Doliba NM, Qin W, Vatamaniuk MZ, Buettger CW, Collins HW, Magnuson MA, Kaestner KH, Wilson DF, Carr RD, Matschinsky FM. Cholinergic regulation of fuel-induced hormone secretion and respiration of SUR1-/- mouse islets. American Journal of Physiology. Endocrinology and Metabolism. 291: E525-35. PMID 16638820 DOI: 10.1152/Ajpendo.00579.2005 |
0.302 |
|
| 2006 |
Garrison WD, Battle MA, Yang C, Kaestner KH, Sladek FM, Duncan SA. Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon. Gastroenterology. 130: 1207-20. PMID 16618389 DOI: 10.1053/J.Gastro.2006.01.003 |
0.458 |
|
| 2006 |
Burkhardt BR, Greene SR, White P, Wong RK, Brestelli JE, Yang J, Robert CE, Brusko TM, Wasserfall CH, Wu J, Atkinson MA, Gao Z, Kaestner KH, Wolf BA. PANDER-induced cell-death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1A (p21). Gene. 369: 134-41. PMID 16412588 DOI: 10.1016/J.Gene.2005.10.040 |
0.397 |
|
| 2006 |
De León DD, Farzad C, Crutchlow MF, Brestelli J, Tobias J, Kaestner KH, Stoffers DA. Identification of transcriptional targets during pancreatic growth after partial pancreatectomy and exendin-4 treatment. Physiological Genomics. 24: 133-43. PMID 16410542 DOI: 10.1152/Physiolgenomics.00156.2005 |
0.456 |
|
| 2006 |
Hara M, Dizon RF, Glick BS, Lee CS, Kaestner KH, Piston DW, Bindokas VP. Imaging pancreatic beta-cells in the intact pancreas. American Journal of Physiology. Endocrinology and Metabolism. 290: E1041-7. PMID 16368785 DOI: 10.1152/Ajpendo.00365.2005 |
0.364 |
|
| 2006 |
Lee CS, De León DD, Kaestner KH, Stoffers DA. Regeneration of pancreatic islets after partial pancreatectomy in mice does not involve the reactivation of neurogenin-3. Diabetes. 55: 269-72. PMID 16361411 |
0.314 |
|
| 2006 |
Lee CS, León DDD, Kaestner KH, Stoffers DA. Regeneration of pancreatic islets after partial pancreatectomy in mice does not involve the reactivation of neurogenin-3. Diabetes. 55: 269-272. DOI: 10.2337/Diabetes.55.02.06.Db05-1300 |
0.424 |
|
| 2005 |
Kaestner KH. Collecting new targets in MODY. Cell Metabolism. 2: 342-344. PMID 16330318 DOI: 10.1016/J.Cmet.2005.11.007 |
0.37 |
|
| 2005 |
Kaestner KH. The making of the liver: developmental competence in foregut endoderm and induction of the hepatogenic program. Cell Cycle. 4: 1146-1148. PMID 16123587 DOI: 10.4161/Cc.4.9.2033 |
0.384 |
|
| 2005 |
Phuc Le P, Friedman JR, Schug J, Brestelli JE, Parker JB, Bochkis IM, Kaestner KH. Glucocorticoid receptor-dependent gene regulatory networks. Plos Genetics. 1: e16. PMID 16110340 DOI: 10.1371/Journal.Pgen.0010016 |
0.791 |
|
| 2005 |
Zhang L, Rubins NE, Ahima RS, Greenbaum LE, Kaestner KH. Foxa2 integrates the transcriptional response of the hepatocyte to fasting. Cell Metabolism. 2: 141-8. PMID 16098831 DOI: 10.1016/J.Cmet.2005.07.002 |
0.401 |
|
| 2005 |
Rubins NE, Friedman JR, Le PP, Zhang L, Brestelli J, Kaestner KH. Transcriptional networks in the liver: hepatocyte nuclear factor 6 function is largely independent of Foxa2. Molecular and Cellular Biology. 25: 7069-77. PMID 16055718 DOI: 10.1128/Mcb.25.16.7069-7077.2005 |
0.405 |
|
| 2005 |
Xiao F, Crissey MAS, Lynch JP, Kaestner KH, Silberg DG, Suh E. Intestinal metaplasia with a high salt diet induces epithelial proliferation and alters cell composition in the gastric mucosa of mice. Cancer Biology & Therapy. 4: 669-675. PMID 15970710 DOI: 10.4161/Cbt.4.6.1734 |
0.327 |
|
| 2005 |
Lee CS, Friedman JR, Fulmer JT, Kaestner KH. The initiation of liver development is dependent on Foxa transcription factors. Nature. 435: 944-7. PMID 15959514 DOI: 10.1038/Nature03649 |
0.391 |
|
| 2005 |
Katz JP, Perreault N, Goldstein BG, Actman L, McNally SR, Silberg DG, Furth EE, Kaestner KH. Loss of Klf4 in mice causes altered proliferation and differentiation and precancerous changes in the adult stomach. Gastroenterology. 128: 935-945. PMID 15825076 DOI: 10.1053/J.Gastro.2005.02.022 |
0.364 |
|
| 2005 |
Gupta RK, Vatamaniuk MZ, Lee CS, Flaschen RC, Fulmer JT, Matschinsky FM, Duncan SA, Kaestner KH. The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion. The Journal of Clinical Investigation. 115: 1006-15. PMID 15761495 DOI: 10.1172/Jci22365 |
0.668 |
|
| 2005 |
Lee CS, Sund NJ, Behr R, Herrera PL, Kaestner KH. Foxa2 is required for the differentiation of pancreatic alpha-cells. Developmental Biology. 278: 484-95. PMID 15680365 DOI: 10.1016/J.Ydbio.2004.10.012 |
0.411 |
|
| 2005 |
Perreault N, Sackett SD, Katz JP, Furth EE, Kaestner KH. Foxl1 is a mesenchymal Modifier of Min in carcinogenesis of stomach and colon. Genes & Development. 19: 311-5. PMID 15650110 DOI: 10.1101/Gad.1260605 |
0.731 |
|
| 2005 |
Lantz KA, Kaestner KH. Winged-helix transcription factors and pancreatic development. Clinical Science (London, England : 1979). 108: 195-204. PMID 15631623 DOI: 10.1042/Cs20040309 |
0.807 |
|
| 2005 |
White P, Brestelli JE, Kaestner KH, Greenbaum LE. Identification of transcriptional networks during liver regeneration. Journal of Biological Chemistry. 280: 3715-3722. PMID 15546871 DOI: 10.1074/Jbc.M410844200 |
0.418 |
|
| 2004 |
Lee CS, Kaestner KH. Development of gut endocrine cells Best Practice & Research Clinical Endocrinology & Metabolism. 18: 453-462. PMID 15533769 DOI: 10.1016/J.Beem.2004.08.008 |
0.44 |
|
| 2004 |
Krupczak-Hollis K, Wang X, Kalinichenko VV, Gusarova GA, Wang IC, Dennewitz MB, Yoder HM, Kiyokawa H, Kaestner KH, Costa RH. The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis. Developmental Biology. 276: 74-88. PMID 15531365 DOI: 10.1016/J.Ydbio.2004.08.022 |
0.405 |
|
| 2004 |
Gupta RK, Kaestner KH. HNF-4alpha: from MODY to late-onset type 2 diabetes. Trends in Molecular Medicine. 10: 521-4. PMID 15519277 DOI: 10.1016/J.Molmed.2004.09.004 |
0.624 |
|
| 2004 |
Friedman JR, Larris B, Le PP, Peiris TH, Arsenlis A, Schug J, Tobias JW, Kaestner KH, Greenbaum LE. Orthogonal analysis of C/EBPbeta targets in vivo during liver proliferation. Proceedings of the National Academy of Sciences of the United States of America. 101: 12986-91. PMID 15317935 DOI: 10.1073/Pnas.0402875101 |
0.336 |
|
| 2004 |
Lantz KA, Vatamaniuk MZ, Brestelli JE, Friedman JR, Matschinsky FM, Kaestner KH. Foxa2 regulates multiple pathways of insulin secretion. The Journal of Clinical Investigation. 114: 512-20. PMID 15314688 DOI: 10.1172/Jci21149 |
0.804 |
|
| 2004 |
Behr R, Brestelli J, Fulmer JT, Miyawaki N, Kleyman TR, Kaestner KH. Mild nephrogenic diabetes insipidus caused by Foxa1 deficiency. Journal of Biological Chemistry. 279: 41936-41941. PMID 15252040 DOI: 10.1074/Jbc.M403354200 |
0.366 |
|
| 2004 |
Katz JP, Perreault N, Goldstein BG, Chao HH, Ferraris RP, Kaestner KH. Foxl1 null mice have abnormal intestinal epithelia, postnatal growth retardation, and defective intestinal glucose uptake. American Journal of Physiology. Gastrointestinal and Liver Physiology. 287: G856-64. PMID 15155178 DOI: 10.1152/Ajpgi.00136.2004 |
0.325 |
|
| 2004 |
Wan H, Kaestner KH, Ang SL, Ikegami M, Finkelman FD, Stahlman MT, Fulkerson PC, Rothenberg ME, Whitsett JA. Foxa2 regulates alveolarization and goblet cell hyperplasia. Development (Cambridge, England). 131: 953-64. PMID 14757645 DOI: 10.1242/Dev.00966 |
0.348 |
|
| 2003 |
Rangwala SM, Rhoades B, Shapiro JS, Rich AS, Kim JK, Shulman GI, Kaestner KH, Lazar MA. Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity. Developmental Cell. 5: 657-63. PMID 14536066 DOI: 10.1016/S1534-5807(03)00274-0 |
0.327 |
|
| 2003 |
Kaestner KH, Lee CS, Scearce LM, Brestelli JE, Arsenlis A, Le PP, Lantz KA, Crabtree J, Pizarro A, Mazzarelli J, Pinney D, Fischer S, Manduchi E, Stoeckert CJ, Gradwohl G, et al. Transcriptional program of the endocrine pancreas in mice and humans. Diabetes. 52: 1604-10. PMID 12829622 DOI: 10.2337/Diabetes.52.7.1604 |
0.785 |
|
| 2003 |
Parviz F, Matullo C, Garrison WD, Savatski L, Adamson JW, Ning G, Kaestner KH, Rossi JM, Zaret KS, Duncan SA. Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis. Nature Genetics. 34: 292-6. PMID 12808453 DOI: 10.1038/Ng1175 |
0.366 |
|
| 2003 |
Katz JP, Kaestner KH. Cellular and molecular mechanisms of carcinogenesis Hematology-Oncology Clinics of North America. 17: 361-376. DOI: 10.1016/S0889-8588(03)00026-1 |
0.356 |
|
| 2003 |
Friedman JR, Le PP, Kaestner KH. 186 Identification of novel HNF6 target genes by high-throughput chromatin immunoprecipitation Hepatology. 38: 244-244. DOI: 10.1016/S0270-9139(03)80229-X |
0.308 |
|
| 2003 |
Perreault N, Dutton-Sackett S, Lee CS, McNally S, Kaestner KH. The winged helix transcription factor foxa2 is required for the control of gastrointestinal epithelial cell proliferation Gastroenterology. 124. DOI: 10.1016/S0016-5085(03)81388-4 |
0.388 |
|
| 2003 |
Katz JP, Perreault N, Goldstein BG, Kaestner KH. The zinc-finger transcription factor Klf4 is required for normal gastric epithelial proliferation and differentiation in vivo Gastroenterology. 124. DOI: 10.1016/S0016-5085(03)80453-5 |
0.34 |
|
| 2002 |
Lee CS, Sund NJ, Vatamaniuk MZ, Matschinsky FM, Stoffers DA, Kaestner KH. Foxa2 controls Pdx1 gene expression in pancreatic beta-cells in vivo. Diabetes. 51: 2546-51. PMID 12145169 DOI: 10.2337/Diabetes.51.8.2546 |
0.468 |
|
| 2002 |
Katz JP, Kaestner KH. Cellular and molecular mechanisms of carcinogenesis. Gastroenterology Clinics of North America. 31: 379-394. PMID 12134609 DOI: 10.1016/S0889-8553(02)00006-7 |
0.356 |
|
| 2002 |
Scearce LM, Brestelli JE, McWeeney SK, Lee CS, Mazzarelli J, Pinney DF, Pizarro A, Stoeckert CJ, Clifton SW, Permutt MA, Brown J, Melton DA, Kaestner KH. Functional genomics of the endocrine pancreas: the pancreas clone set and PancChip, new resources for diabetes research. Diabetes. 51: 1997-2004. PMID 12086925 DOI: 10.2337/Diabetes.51.7.1997 |
0.331 |
|
| 2002 |
Lee CS, Perreault N, Brestelli JE, Kaestner KH. Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity Genes & Development. 16: 1488-1497. PMID 12080087 DOI: 10.1101/Gad.985002 |
0.397 |
|
| 2002 |
Behr R, Kaestner KH. Developmental and cell type-specific expression of the zinc finger transcription factor Krüppel-like factor 4 (Klf4) in postnatal mouse testis. Mechanisms of Development. 115: 167-169. PMID 12049784 DOI: 10.1016/S0925-4773(02)00127-2 |
0.464 |
|
| 2002 |
Katz JP, Perreault N, Goldstein BG, Lee CS, Labosky PA, Yang VW, Kaestner KH. The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development (Cambridge, England). 129: 2619-28. PMID 12015290 DOI: 10.1242/dev.129.11.2619 |
0.326 |
|
| 2002 |
Liu Y, Shen W, Brubaker PL, Kaestner KH, Drucker DJ. Foxa3 (HNF-3gamma) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression. The Biochemical Journal. 366: 633-41. PMID 12000309 DOI: 10.1042/Bj20020095 |
0.457 |
|
| 2002 |
Silberg DG, Sullivan J, Kang E, Swain GP, Moffett J, Sund NJ, Sackett SD, Kaestner KH. Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Gastroenterology. 122: 689-96. PMID 11875002 DOI: 10.1053/Gast.2002.31902 |
0.72 |
|
| 2002 |
Parviz F, Li J, Kaestner KH, Duncan SA. Generation of a conditionally null allele of hnf4alpha. Genesis (New York, N.Y. : 2000). 32: 130-3. PMID 11857799 DOI: 10.1002/Gene.10058 |
0.324 |
|
| 2001 |
Perreault N, Katz JP, Sackett SD, Kaestner KH. Foxl1 controls the Wnt/beta-catenin pathway by modulating the expression of proteoglycans in the gut. The Journal of Biological Chemistry. 276: 43328-33. PMID 11555641 DOI: 10.1074/Jbc.M104366200 |
0.748 |
|
| 2001 |
Shen W, Scearce LM, Brestelli JE, Sund NJ, Kaestner KH. Foxa3 (Hepatocyte Nuclear Factor 3γ) is Required for the Regulation of Hepatic GLUT2 Expression and the Maintenance of Glucose Homeostasis during a Prolonged Fast Journal of Biological Chemistry. 276: 42812-42817. PMID 11546810 DOI: 10.1074/Jbc.M106344200 |
0.442 |
|
| 2001 |
Waltz SE, Eaton L, Toney-Earley K, Hess KA, Peace BE, Ihlendorf JR, Wang MH, Kaestner KH, Degen SJ. Ron-mediated cytoplasmic signaling is dispensable for viability but is required to limit inflammatory responses. The Journal of Clinical Investigation. 108: 567-76. PMID 11518730 DOI: 10.1172/Jci11881 |
0.359 |
|
| 2001 |
Sund NJ, Vatamaniuk MZ, Casey M, Ang SL, Magnuson MA, Stoffers DA, Matschinsky FM, Kaestner KH. Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia. Genes & Development. 15: 1706-15. PMID 11445544 DOI: 10.1101/Gad.901601 |
0.417 |
|
| 2001 |
Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, Crenshaw EB, Kaestner KH, Bartolomei MS, Shulman GI, Birnbaum MJ. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ) Science. 292: 1728-1731. PMID 11387480 DOI: 10.1126/Science.292.5522.1728 |
0.327 |
|
| 2001 |
Mukherjee D, Kaestner KH, Kovalovich KK, Greenbaum LE. Fas‐induced apoptosis in mouse hepatocytes is dependent on C/EBPβ Hepatology. 33: 1166-1172. PMID 11343245 DOI: 10.1053/Jhep.2001.24032 |
0.329 |
|
| 2001 |
Silberg DG, Sullivan J, Kang E, Moffett J, Sund NJ, Sackett SD, Kaestner KH. Gastric intestinal metaplasia is induced by ectopic expression of Cdx2 Gastroenterology. 120: A139-A140. DOI: 10.1016/S0016-5085(08)80688-9 |
0.689 |
|
| 2000 |
Kaestner KH. The hepatocyte nuclear factor 3 (HNF3 or FOXA) family in metabolism. Trends in Endocrinology and Metabolism. 11: 281-285. PMID 10920385 DOI: 10.1016/S1043-2760(00)00271-X |
0.406 |
|
| 2000 |
Sund NJ, Ang SL, Sackett SD, Shen W, Daigle N, Magnuson MA, Kaestner KH. Hepatocyte nuclear factor 3β (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte Molecular and Cellular Biology. 20: 5175-5183. PMID 10866673 DOI: 10.1128/Mcb.20.14.5175-5183.2000 |
0.756 |
|
| 2000 |
Leatherman JL, Kaestner KH, Jongens TA. Identification of a mouse germ cell-less homologue with conserved activity in Drosophila. Mechanisms of Development. 92: 145-53. PMID 10727854 DOI: 10.1016/S0925-4773(99)00335-4 |
0.408 |
|
| 2000 |
Mahatan CS, Kaestner KH, Geiman DE, Yang VW. Characterization of the structure and regulation of the murine gene encoding gut-enriched Krüppel-like factor (Krüppel-like factor 4). Nucleic Acids Research. 27: 4562-9. PMID 10556311 DOI: 10.1093/Nar/27.23.4562 |
0.388 |
|
| 2000 |
Kaestner KH, Knöchel W, Martínez DE. Unified nomenclature for the winged helix/forkhead transcription factors Genes & Development. 14: 142-146. DOI: 10.1101/Gad.14.2.142 |
0.318 |
|
| 2000 |
Perreault N, Katz JP, Kaestner KH. The mesenchymal transcription factor Fkh6 affects the Wnt/b-catenin pathway by modulating the expression of proteoglycans in the gut epithelium Gastroenterology. 118. DOI: 10.1016/S0016-5085(00)83262-X |
0.357 |
|
| 2000 |
Katz JP, Yang VW, Kaestner KH. The zinc-finger transcription factor Klf4 in the regulation of gastrointestinal epithelial proliferation and differentiation in vivo Gastroenterology. 118: A289. DOI: 10.1016/S0016-5085(00)83243-6 |
0.38 |
|
| 1999 |
Kaestner KH, Katz J, Liu Y, Drucker DJ, Schütz G. Inactivation of the winged helix transcription factor HNF3α affects glucose homeostasis and islet glucagon gene expression in vivo Genes & Development. 13: 495-504. PMID 10049364 DOI: 10.1101/Gad.13.4.495 |
0.439 |
|
| 1998 |
Christoffels VM, Grange T, Kaestner KH, Cole TJ, Darlington GJ, Croniger CM, Lamers WH. Glucocorticoid Receptor, C/EBP, HNF3, and Protein Kinase A Coordinately Activate the Glucocorticoid Response Unit of the Carbamoylphosphate Synthetase I Gene Molecular and Cellular Biology. 18: 6305-6315. PMID 9774647 DOI: 10.1128/Mcb.18.11.6305 |
0.413 |
|
| 1998 |
Labosky PA, Kaestner KH. The winged helix transcription factor Hfh2 is expressed in neural crest and spinal cord during mouse development. Mechanisms of Development. 76: 185-190. PMID 9767163 DOI: 10.1016/S0925-4773(98)00105-1 |
0.365 |
|
| 1998 |
Hiemisch H, Schütz G, Kaestner KH. The mouse Fkh1/Mf1 gene: cDNA sequence, chromosomal localization and expression in adult tissues Gene. 220: 77-82. PMID 9767123 DOI: 10.1016/S0378-1119(98)00409-0 |
0.348 |
|
| 1998 |
Reichardt HM, Kaestner KH, Wessely O, Gass P, Schmid W, Schütz G. Analysis of glucocorticoid signalling by gene targeting The Journal of Steroid Biochemistry and Molecular Biology. 65: 111-115. PMID 9699863 DOI: 10.1016/S0960-0760(97)00181-7 |
0.402 |
|
| 1998 |
Kaestner KH, Hiemisch H, Schütz G. Targeted Disruption of the Gene Encoding Hepatocyte Nuclear Factor 3γ Results in Reduced Transcription of Hepatocyte-Specific Genes Molecular and Cellular Biology. 18: 4245-4251. PMID 9632808 DOI: 10.1128/Mcb.18.7.4245 |
0.44 |
|
| 1998 |
Reichardt HM, Kaestner KH, Tuckermann J, Kretz O, Wessely O, Bock R, Gass P, Schmid W, Herrlich P, Angel P, Schütz G. DNA binding of the glucocorticoid receptor is not essential for survival Cell. 93: 531-541. PMID 9604929 DOI: 10.1016/S0092-8674(00)81183-6 |
0.349 |
|
| 1998 |
Hiemisch H, Monaghan AP, Schütz G, Kaestner KH. Expression of the mouse Fkh1/Mf1 and Mfh1 genes in late gestation embryos is restricted to mesoderm derivatives Mechanisms of Development. 73: 129-132. PMID 9545561 DOI: 10.1016/S0925-4773(98)00039-2 |
0.364 |
|
| 1997 |
Ton-That H, Kaestner KH, Shields JM, Mahatanankoon CS, Yang VW. Expression of the gut-enriched Kruppel-like factor gene during development and intestinal tumorigenesis Febs Letters. 419: 239-243. PMID 9428642 DOI: 10.1016/S0014-5793(97)01465-8 |
0.379 |
|
| 1997 |
Hiemisch H, Schütz G, Kaestner KH. Transcriptional regulation in endoderm development: characterization of an enhancer controlling Hnf3g expression by transgenesis and targeted mutagenesis. The Embo Journal. 16: 3995-4006. PMID 9233809 DOI: 10.1093/Emboj/16.13.3995 |
0.439 |
|
| 1997 |
Kaestner KH, Silberg DG, Traber PG, Schütz G. The mesenchymal winged helix transcription factor Fkh6 is required for the control of gastrointestinal proliferation and differentiation. Genes & Development. 11: 1583-1595. PMID 9203584 DOI: 10.1101/Gad.11.12.1583 |
0.428 |
|
| 1997 |
Mincheva A, Lichter P, Schütz G, Kaestner KH. Assignment of the Human Genes for Hepatocyte Nuclear Factor 3-α, -β, and -γ (HNF3A, HNF3B, HNF3G) to 14q12–q13, 20p11, and 19q13.2–q13.4 Genomics. 39: 417-419. PMID 9119385 DOI: 10.1006/Geno.1996.4477 |
0.406 |
|
| 1996 |
Kaestner KH, Schütz G, Monaghan AP. Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system. Mechanisms of Development. 55: 221-230. PMID 8861101 DOI: 10.1016/0925-4773(96)00507-2 |
0.339 |
|
| 1996 |
Ott T, Kaestner KH, Monaghan AP, Schütz G. The mouse homolog of the region specific homeotic gene spalt of Drosophila is expressed in the developing nervous system and in mesoderm-derived structures Mechanisms of Development. 56: 117-128. PMID 8798152 DOI: 10.1016/0925-4773(96)00516-3 |
0.343 |
|
| 1996 |
Blendy JA, Kaestner KH, Weinbauer GF, Nieschlag E, Schütz G. Severe impairment of spermatogenesis in mice lacking the CREM gene. Nature. 380: 162-5. PMID 8600391 DOI: 10.1038/380162A0 |
0.409 |
|
| 1996 |
Blendy JA, Kaestner KH, Schmid W, Gass P, Schütz G. Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform. The Embo Journal. 15: 1098-1106. DOI: 10.1002/J.1460-2075.1996.Tb00447.X |
0.412 |
|
| 1995 |
Kaestner KH, Monaghan AP, Kern H, Ang SL, Weitz S, Lichter P, Schütz G. The Mouse fkh-2 Gene IMPLICATIONS FOR NOTOCHORD, FOREGUT, AND MIDBRAIN REGIONALIZATION Journal of Biological Chemistry. 270: 30029-30035. PMID 8530406 DOI: 10.1074/Jbc.270.50.30029 |
0.395 |
|
| 1994 |
Kaestner KH, Hiemisch H, Luckow B, Schütz G. The HNF-3 gene family of transcription factors in mice : gene structure, cDNA sequence, and mRNA distribution Genomics. 20: 377-385. PMID 8034310 DOI: 10.1006/Geno.1994.1191 |
0.387 |
|
| 1994 |
Kaestner KH, Montoliu L, Kern H, Thulke M, Schütz G. Universal β-galactosidase cloning vectors for promoter analysis and gene targeting Gene. 148: 67-70. PMID 7926839 DOI: 10.1016/0378-1119(94)90234-8 |
0.331 |
|
| 1993 |
Ezaki O, Flores-Riveros JR, Kaestner KH, Gearhart J, Lane MD. Regulated expression of an insulin-responsive glucose transporter (GLUT4) minigene in 3T3-L1 adipocytes and transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 90: 3348-52. PMID 8475079 DOI: 10.1073/Pnas.90.8.3348 |
0.412 |
|
| 1993 |
Flores-Riveros JR, Kaestner KH, Thompson KS, Lane MD. Cyclic AMP-induced transcriptional repression of the insulin-responsive glucose transporter (GLUT4) gene: identification of a promoter region required for down-regulation of transcription. Biochemical and Biophysical Research Communications. 194: 1148-54. PMID 8352771 DOI: 10.1006/Bbrc.1993.1942 |
0.392 |
|
| 1993 |
Kaestner KH, Lee K, Schlöndorff J, Hiemisch H, Monaghan AP, Schütz G. Six members of the mouse forkhead gene family are developmentally regulated. Proceedings of the National Academy of Sciences of the United States of America. 90: 7628-7631. PMID 7689224 DOI: 10.1073/Pnas.90.16.7628 |
0.386 |
|
| 1991 |
Christy RJ, Kaestner KH, Geiman DE, Lane MD. CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes. Proceedings of the National Academy of Sciences of the United States of America. 88: 2593-7. PMID 2006196 DOI: 10.1073/Pnas.88.6.2593 |
0.378 |
|
| 1991 |
Narayanan V, Kaestner KH, Tennekoon GI. Structure of the mouse myelin P2 protein gene. Journal of Neurochemistry. 57: 75-80. PMID 1711100 DOI: 10.1111/J.1471-4159.1991.Tb02101.X |
0.32 |
|
| 1991 |
Kaestner KH, Flores-Riveros JR, McLenithan JC, Janicot M, Lane MD. Transcriptional repression of the mouse insulin-responsive glucose transporter (GLUT4) gene by cAMP. Proceedings of the National Academy of Sciences of the United States of America. 88: 1933-7. PMID 1705711 DOI: 10.1073/Pnas.88.5.1933 |
0.338 |
|
| 1990 |
Kaestner KH, Christy RJ, Lane MD. Mouse insulin-responsive glucose transporter gene: characterization of the gene and trans-activation by the CCAAT/enhancer binding protein. Proceedings of the National Academy of Sciences of the United States of America. 87: 251-5. PMID 2404278 DOI: 10.1073/Pnas.87.1.251 |
0.381 |
|
| 1990 |
Lane MD, Flores-Riveros JR, Hresko RC, Kaestner KH, Liao K, Janicot M, Hoffman RD, McLenithan JC, Kastelic T, Christy RJ. Insulin-receptor tyrosine kinase and glucose transport. Diabetes Care. 13: 565-75. PMID 2162754 DOI: 10.2337/Diacare.13.6.565 |
0.305 |
|
| 1989 |
Kaestner KH, Christy RJ, McLenithan JC, Braiterman LT, Cornelius P, Pekala PH, Lane MD. Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes Proceedings of the National Academy of Sciences of the United States of America. 86: 3150-3154. PMID 2654938 DOI: 10.1073/Pnas.86.9.3150 |
0.303 |
|
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