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Weihang Chai - Publications

Affiliations: 
Molecular Biosciences Washington State University, Pullman, WA, United States 
Area:
Molecular Biology, Cell Biology, Genetics
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40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Jaiswal RK, Lei KH, Chastain M, Wang Y, Shiva O, Li S, You Z, Chi P, Chai W. CaMKK2 and CHK1 phosphorylate human STN1 in response to replication stress to protect stalled forks from aberrant resection. Nature Communications. 14: 7882. PMID 38036565 DOI: 10.1038/s41467-023-43685-2  0.376
2023 Nguyen DD, Kim E, Le NT, Ding X, Jaiswal RK, Kostlan RJ, Nguyen TNT, Shiva O, Le MT, Chai W. Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair. Science Advances. 9: eadd8023. PMID 37163605 DOI: 10.1126/sciadv.add8023  0.37
2021 Lei KH, Yang HL, Chang HY, Yeh HY, Nguyen DD, Lee TY, Lyu X, Chastain M, Chai W, Li HW, Chi P. Crosstalk between CST and RPA regulates RAD51 activity during replication stress. Nature Communications. 12: 6412. PMID 34741010 DOI: 10.1038/s41467-021-26624-x  0.383
2021 Chai W, Chastain M, Shiva O, Wang Y. The Intrinsically Disordered Region in the Human STN1 OB-Fold Domain Is Important for Protecting Genome Stability. Biology. 10. PMID 34681076 DOI: 10.3390/biology10100977  0.382
2021 Lyu X, Sang PB, Chai W. CST in maintaining genome stability: Beyond telomeres. Dna Repair. 102: 103104. PMID 33780718 DOI: 10.1016/j.dnarep.2021.103104  0.503
2020 Lyu X, Lei KH, Biak Sang P, Shiva O, Chastain M, Chi P, Chai W. Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent-strand DNA. The Embo Journal. e103654. PMID 33210317 DOI: 10.15252/embj.2019103654  0.522
2020 Nguyen DD, Kim EY, Sang PB, Chai W. Roles of OB-Fold Proteins in Replication Stress. Frontiers in Cell and Developmental Biology. 8: 574466. PMID 33043007 DOI: 10.3389/fcell.2020.574466  0.485
2019 Lyu X, Chastain M, Chai W. Genome-wide mapping and profiling of γH2AX binding hotspots in response to different replication stress inducers. Bmc Genomics. 20: 579. PMID 31299901 DOI: 10.1186/S12864-019-5934-4  0.387
2018 Jia P, Chai W. The MLH1 ATPase domain is needed for suppressing aberrant formation of interstitial telomeric sequences. Dna Repair. 65: 20-25. PMID 29544212 DOI: 10.1016/J.Dnarep.2018.03.002  0.526
2018 Wang Y, Chai W. Pathogenic CTC1 mutations cause global genome instabilities under replication stress. Nucleic Acids Research. PMID 29481669 DOI: 10.1093/Nar/Gky114  0.451
2017 Huang C, Jia P, Chastain M, Shiva O, Chai W. The Human CTC1/STN1/TEN1 Complex Regulates Telomere maintenance in ALT Cancer Cells. Experimental Cell Research. PMID 28366536 DOI: 10.1016/J.Yexcr.2017.03.058  0.566
2017 Jia P, Chastain M, Zou Y, Her C, Chai W. Human MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells. Nucleic Acids Research. 45: 1219-1232. PMID 28180301 DOI: 10.1093/Nar/Gkw1170  0.564
2016 Jia P, Chastain M, Zou Y, Her C, Chai W. Human MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells. Nucleic Acids Research. PMID 27903905 DOI: 10.1093/nar/gkw1170  0.488
2016 Chastain M, Zhou Q, Shiva O, Whitmore L, Jia P, Dai X, Huang C, Fadri-Moskwik M, Ye P, Chai W. Human CST Facilitates Genome-wide RAD51 Recruitment to GC-Rich Repetitive Sequences in Response to Replication Stress. Cell Reports. 16: 1300-1314. PMID 27487043 DOI: 10.1016/J.Celrep.2016.06.077  0.451
2016 Zhou Q, Chai W. Suppression of STN1 enhances the cytotoxicity of chemotherapeutic agents in cancer cells by elevating DNA damage. Oncology Letters. 12: 800-808. PMID 27446354 DOI: 10.3892/ol.2016.4676  0.314
2015 Jia P, Her C, Chai W. DNA excision repair at telomeres. Dna Repair. 36: 137-45. PMID 26422132 DOI: 10.1016/J.Dnarep.2015.09.017  0.602
2015 Chung L, Onyango D, Guo Z, Jia P, Dai H, Liu S, Zhou M, Lin W, Pang I, Li H, Yuan YC, Huang Q, Zheng L, Lopes J, Nicolas A, ... Chai W, et al. The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN activity, causing aneuploidy-associated cancers. Oncogene. 34: 902-11. PMID 24608430 DOI: 10.1038/Onc.2014.19  0.488
2014 Shi J, Yang XR, Ballew B, Rotunno M, Calista D, Fargnoli MC, Ghiorzo P, Paillerets BB, Nagore E, Hua X, Hyland P, Yin J, Vallabhaneni H, Chai W, Ravichandran S, et al. Abstract 941: Exome sequencing identifiedPOT1, a telomere shelterin gene, as a major susceptibility gene for familial cutaneous malignant melanoma Cancer Research. 74: 941-941. DOI: 10.1158/1538-7445.Am2014-941  0.345
2013 Fadri-Moskwik M, Zhou Q, Chai W. Beyond Telomerase: Telomere Instability as a Novel Target for Cancer Therapy. Journal of Molecular and Genetic Medicine : An International Journal of Biomedical Research. 7. PMID 27123041 DOI: 10.4172/1747-0862.1000091  0.526
2013 Chai W, Zheng L, Shen B. DNA2, a new player in telomere maintenance and tumor suppression. Cell Cycle (Georgetown, Tex.). 12: 1985-6. PMID 23759580 DOI: 10.4161/Cc.25306  0.711
2013 Lin W, Sampathi S, Dai H, Liu C, Zhou M, Hu J, Huang Q, Campbell J, Shin-Ya K, Zheng L, Chai W, Shen B. Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity. The Embo Journal. 32: 1425-39. PMID 23604072 DOI: 10.1038/Emboj.2013.88  0.77
2012 Huang C, Dai X, Chai W. Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-in. Cell Research. 22: 1681-95. PMID 22964711 DOI: 10.1038/Cr.2012.132  0.678
2012 Dai X, Huang C, Chai W. CDK1 differentially regulates G-overhang generation at leading- and lagging-strand telomeres in telomerase-negative cells in G2 phase. Cell Cycle (Georgetown, Tex.). 11: 3079-86. PMID 22871736 DOI: 10.4161/Cc.21472  0.622
2012 Gu P, Min JN, Wang Y, Huang C, Peng T, Chai W, Chang S. CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion. The Embo Journal. 31: 2309-21. PMID 22531781 DOI: 10.1038/Emboj.2012.96  0.63
2012 Huang C, Dai X, Chai W. Abstract 2039: Human Stn1 protects telomere integrity by promoting efficient lagging strand synthesis at telomeres Cancer Research. 72: 2039-2039. DOI: 10.1158/1538-7445.Am2012-2039  0.702
2011 Wu X, Xu Y, Chai W, Her C. Causal link between microsatellite instability and hMRE11 dysfunction in human cancers. Molecular Cancer Research : McR. 9: 1443-8. PMID 21849470 DOI: 10.1158/1541-7786.Mcr-11-0322  0.543
2011 Sampathi S, Chai W. Mapping the FEN1 interaction domain with hTERT. Biochemical and Biophysical Research Communications. 407: 34-8. PMID 21345332 DOI: 10.1016/J.Bbrc.2011.02.087  0.73
2011 Sampathi S, Chai W. Telomere replication: poised but puzzling. Journal of Cellular and Molecular Medicine. 15: 3-13. PMID 21122064 DOI: 10.1111/J.1582-4934.2010.01220.X  0.756
2010 Dai X, Huang C, Bhusari A, Sampathi S, Schubert K, Chai W. Molecular steps of G-overhang generation at human telomeres and its function in chromosome end protection. The Embo Journal. 29: 2788-801. PMID 20639858 DOI: 10.1038/Emboj.2010.156  0.745
2009 Sampathi S, Bhusari A, Shen B, Chai W. Human flap endonuclease I is in complex with telomerase and is required for telomerase-mediated telomere maintenance. The Journal of Biological Chemistry. 284: 3682-90. PMID 19068479 DOI: 10.1074/Jbc.M805362200  0.77
2007 Gardner JP, Kimura M, Chai W, Durrani JF, Tchakmakjian L, Cao X, Lu X, Li G, Peppas AP, Skurnick J, Wright WE, Shay JW, Aviv A. Telomere dynamics in macaques and humans. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 62: 367-74. PMID 17452729 DOI: 10.1093/Gerona/62.4.367  0.375
2006 Chai W, Du Q, Shay JW, Wright WE. Human telomeres have different overhang sizes at leading versus lagging strands. Molecular Cell. 21: 427-35. PMID 16455497 DOI: 10.1016/J.Molcel.2005.12.004  0.588
2006 Chai W, Sfeir AJ, Hoshiyama H, Shay JW, Wright WE. The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres. Embo Reports. 7: 225-30. PMID 16374507 DOI: 10.1038/Sj.Embor.7400600  0.646
2005 Sfeir AJ, Chai W, Shay JW, Wright WE. Telomere-end processing the terminal nucleotides of human chromosomes. Molecular Cell. 18: 131-8. PMID 15808515 DOI: 10.1016/J.Molcel.2005.02.035  0.615
2005 Chai W, Shay JW, Wright WE. Human telomeres maintain their overhang length at senescence. Molecular and Cellular Biology. 25: 2158-68. PMID 15743814 DOI: 10.1128/Mcb.25.6.2158-2168.2005  0.483
2004 Sawyer SL, Cheng IH, Chai W, Tye BK. Mcm10 and Cdc45 cooperate in origin activation in Saccharomyces cerevisiae. Journal of Molecular Biology. 340: 195-202. PMID 15201046 DOI: 10.1016/J.Jmb.2004.04.066  0.501
2002 Chai W, Ford LP, Lenertz L, Wright WE, Shay JW. Human Ku70/80 associates physically with telomerase through interaction with hTERT. The Journal of Biological Chemistry. 277: 47242-7. PMID 12377759 DOI: 10.1074/Jbc.M208542200  0.646
1999 Wu SQ, Chai W, Lin JT, Stewart V. General Nitrogen Regulation of Nitrate Assimilation Regulatory Gene nasR Expression in Klebsiella oxytoca M5al Journal of Bacteriology. 181: 7274-7284. PMID 10572131 DOI: 10.1128/Jb.181.23.7274-7284.1999  0.318
1999 Chai W, Stewart V. RNA sequence requirements for NasR-mediated, nitrate-responsive transcription antitermination of the Klebsiella oxytoca M5al nasF operon leader Journal of Molecular Biology. 292: 203-216. PMID 10493869 DOI: 10.1006/Jmbi.1999.3084  0.316
1998 Chai W, Stewart V. NasR, a novel RNA-binding protein, mediates nitrate-responsive transcription antitermination of the Klebsiella oxytoca M5al nasF operon leader in vitro Journal of Molecular Biology. 283: 339-351. PMID 9769209 DOI: 10.1006/Jmbi.1998.2105  0.333
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