Lu Chen, Ph.D. - Publications

Affiliations: 
2021- Fox Chase Cancer Center, Philadelphia 
Area:
telomere and telomerase, RNA biology, aging
Website:
www.luchenlab.org

18 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Huda A, Arakawa H, Mazzucco G, Galli M, Petrocelli V, Casola S, Chen L, Doksani Y. The telomerase reverse transcriptase elongates reversed replication forks at telomeric repeats. Science Advances. 9: eadf2011. PMID 36947627 DOI: 10.1126/sciadv.adf2011  0.753
2022 Liu Y, Liu JE, Chen S, Zhao F, Chen L, Li R. Effectiveness of Nonpharmacologic Interventions for Chemotherapy-Related Cognitive Impairment in Breast Cancer Patients: A Systematic Review and Network Meta-analysis. Cancer Nursing. 46: E305-E319. PMID 37607381 DOI: 10.1097/NCC.0000000000001152  0.313
2022 Chen L, Roake CM, Maccallini P, Bavasso F, Dehghannasiri R, Santonicola P, Mendoza-Ferreira N, Scatolini L, Rizzuti L, Esposito A, Gallotta I, Francia S, Cacchione S, Galati A, Palumbo V, et al. TGS1 impacts snRNA 3'-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration. Nucleic Acids Research. PMID 35947650 DOI: 10.1093/nar/gkac659  0.628
2021 Galati A, Scatolini L, Micheli E, Bavasso F, Cicconi A, Maccallini P, Chen L, Roake CM, Schoeftner S, Artandi SE, Gatti M, Cacchione S, Raffa GD. The S-adenosylmethionine analog sinefungin inhibits the trimethylguanosine synthase TGS1 to promote telomerase activity and telomere lengthening. Febs Letters. PMID 34817067 DOI: 10.1002/1873-3468.14240  0.639
2021 Chen L, Chang HY, Artandi SE. Analysis of RNA conformation in endogenously assembled RNPs by icSHAPE. Star Protocols. 2: 100477. PMID 33997809 DOI: 10.1016/j.xpro.2021.100477  0.62
2021 Vaidyanathan S, Baik R, Chen L, Bravo DT, Suarez CJ, Abazari SM, Salahudeen AA, Dudek AM, Teran CA, Davis TH, Lee CM, Bao G, Randell SH, Artandi SE, Wine JJ, et al. Targeted replacement of full-length CFTR in human airway stem cells by CRISPR/Cas9 for pan-mutation correction in the endogenous locus. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 33794364 DOI: 10.1016/j.ymthe.2021.03.023  0.622
2020 Chen L, Bellone RR, Wang Y, Singer-Berk M, Sugasawa K, Ford JM, Artandi SE. A novel DDB2 mutation causes defective recognition of UV-induced DNA damages and prevalent equine squamous cell carcinoma. Dna Repair. 97: 103022. PMID 33276309 DOI: 10.1016/j.dnarep.2020.103022  0.627
2020 Chen L, Roake CM, Galati A, Bavasso F, Micheli E, Saggio I, Schoeftner S, Cacchione S, Gatti M, Artandi SE, Raffa GD. Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation. Cell Reports. 30: 1358-1372.e5. PMID 32023455 DOI: 10.1016/J.Celrep.2020.01.004  0.648
2019 Roake CM, Chen L, Chakravarthy AL, Ferrell JE, Raffa GD, Artandi SE. Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease. Molecular Cell. PMID 30930056 DOI: 10.1016/J.Molcel.2019.02.033  0.706
2018 Chen L, Roake CM, Freund A, Batista PJ, Tian S, Yin YA, Gajera CR, Lin S, Lee B, Pech MF, Venteicher AS, Das R, Chang HY, Artandi SE. An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1. Cell. PMID 29804836 DOI: 10.1016/J.Cell.2018.04.039  0.752
2018 Lin S, Nascimento EM, Gajera CR, Chen L, Neuhöfer P, Garbuzov A, Wang S, Artandi SE. Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury. Nature. PMID 29618815 DOI: 10.1038/S41586-018-0004-7  0.615
2014 Wang L, Limbo O, Fei J, Chen L, Kim B, Luo J, Chong J, Conaway RC, Conaway JW, Ranish JA, Kadonaga JT, Russell P, Wang D. Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif. Proceedings of the National Academy of Sciences of the United States of America. 111: 18566-71. PMID 25512493 DOI: 10.1073/Pnas.1420227112  0.583
2014 Chen L, Ooi SK, Conaway JW, Conaway RC. Biochemical assays for analyzing activities of ATP-dependent chromatin remodeling enzymes Journal of Visualized Experiments. PMID 25407555 DOI: 10.3791/51721  0.748
2014 Chen L, Ooi SK, Conaway RC, Conaway JW. Generation and purification of human INO80 chromatin remodeling complexes and subcomplexes Journal of Visualized Experiments. PMID 25407439 DOI: 10.3791/51720  0.755
2013 Chen L, Conaway RC, Conaway JW. Multiple modes of regulation of the human Ino80 SNF2 ATPase by subunits of the INO80 chromatin-remodeling complex. Proceedings of the National Academy of Sciences of the United States of America. 110: 20497-502. PMID 24297934 DOI: 10.1073/Pnas.1317092110  0.59
2013 Sela D, Conkright JJ, Chen L, Gilmore J, Washburn MP, Florens L, Conaway RC, Conaway JW. Role for human mediator subunit MED25 in recruitment of mediator to promoters by endoplasmic reticulum stress-responsive transcription factor ATF6α. The Journal of Biological Chemistry. 288: 26179-87. PMID 23864652 DOI: 10.1074/Jbc.M113.496968  0.57
2012 Sela D, Chen L, Martin-Brown S, Washburn MP, Florens L, Conaway JW, Conaway RC. Endoplasmic reticulum stress-responsive transcription factor ATF6α directs recruitment of the Mediator of RNA polymerase II transcription and multiple histone acetyltransferase complexes. The Journal of Biological Chemistry. 287: 23035-45. PMID 22577136 DOI: 10.1074/Jbc.M112.369504  0.573
2011 Chen L, Cai Y, Jin J, Florens L, Swanson SK, Washburn MP, Conaway JW, Conaway RC. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. The Journal of Biological Chemistry. 286: 11283-9. PMID 21303910 DOI: 10.1074/Jbc.M111.222505  0.583
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