Juan P. Bolaños - Publications

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140 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Morant-Ferrando B, Jimenez-Blasco D, Alonso-Batan P, Agulla J, Lapresa R, Garcia-Rodriguez D, Yunta-Sanchez S, Lopez-Fabuel I, Fernandez E, Carmeliet P, Almeida A, Garcia-Macia M, Bolaños JP. Fatty acid oxidation organizes mitochondrial supercomplexes to sustain astrocytic ROS and cognition. Nature Metabolism. PMID 37460843 DOI: 10.1038/s42255-023-00835-6  0.34
2023 Jimenez-Blasco D, Almeida A, Bolaños JP. Brightness and shadows of mitochondrial ROS in the brain. Neurobiology of Disease. 184: 106199. PMID 37321421 DOI: 10.1016/j.nbd.2023.106199  0.387
2023 Almeida A, Jimenez-Blasco D, Bolaños JP. Cross-talk between energy and redox metabolism in astrocyte-neuron functional cooperation. Essays in Biochemistry. 67: 17-26. PMID 36805653 DOI: 10.1042/EBC20220075  0.401
2022 Lopez-Fabuel I, Garcia-Macia M, Buondelmonte C, Burmistrova O, Bonora N, Alonso-Batan P, Morant-Ferrando B, Vicente-Gutierrez C, Jimenez-Blasco D, Quintana-Cabrera R, Fernandez E, Llop J, Ramos-Cabrer P, Sharaireh A, Guevara-Ferrer M, et al. Aberrant upregulation of the glycolytic enzyme PFKFB3 in CLN7 neuronal ceroid lipofuscinosis. Nature Communications. 13: 536. PMID 35087090 DOI: 10.1038/s41467-022-28191-1  0.359
2021 Bonvento G, Bolaños JP. Astrocyte-neuron metabolic cooperation shapes brain activity. Cell Metabolism. 33: 1546-1564. PMID 34348099 DOI: 10.1016/j.cmet.2021.07.006  0.378
2021 Barrio E, Vecino R, Sánchez-Morán I, Rodríguez C, Suárez-Pindado A, Bolaños JP, Almeida A, Delgado-Esteban M. Preconditioning-Activated AKT Controls Neuronal Tolerance to Ischemia through the MDM2-p53 Pathway. International Journal of Molecular Sciences. 22. PMID 34298892 DOI: 10.3390/ijms22147275  0.318
2021 Quintana-Cabrera R, Manjarrés-Raza I, Vicente-Gutiérrez C, Corrado M, Bolaños JP, Scorrano L. Opa1 relies on cristae preservation and ATP synthase to curtail reactive oxygen species accumulation in mitochondria. Redox Biology. 41: 101944. PMID 33780775 DOI: 10.1016/j.redox.2021.101944  0.302
2021 Vicente-Gutierrez C, Bonora N, Jimenez-Blasco D, Lopez-Fabuel I, Bates G, Murphy MP, Almeida A, Bolaños JP. Abrogating mitochondrial ROS in neurons or astrocytes reveals cell-specific impact on mouse behaviour. Redox Biology. 41: 101917. PMID 33711713 DOI: 10.1016/j.redox.2021.101917  0.363
2020 Lechuga-Vieco AV, Latorre-Pellicer A, Johnston IG, Prota G, Gileadi U, Justo-Méndez R, Acín-Pérez R, Martínez-de-Mena R, Fernández-Toro JM, Jimenez-Blasco D, Mora A, Nicolás-Ávila JA, Santiago DJ, Priori SG, Bolaños JP, et al. Cell identity and nucleo-mitochondrial genetic context modulate OXPHOS performance and determine somatic heteroplasmy dynamics. Science Advances. 6: eaba5345. PMID 32832682 DOI: 10.1126/Sciadv.Aba5345  0.351
2020 Maugard M, Vigneron PA, Bolaños JP, Bonvento G. l-Serine links metabolism with neurotransmission. Progress in Neurobiology. 101896. PMID 32798642 DOI: 10.1016/J.Pneurobio.2020.101896  0.401
2020 Jimenez-Blasco D, Busquets-Garcia A, Hebert-Chatelain E, Serrat R, Vicente-Gutierrez C, Ioannidou C, Gómez-Sotres P, Lopez-Fabuel I, Resch-Beusher M, Resel E, Arnouil D, Saraswat D, Varilh M, Cannich A, Julio-Kalajzic F, et al. Glucose metabolism links astroglial mitochondria to cannabinoid effects. Nature. 583: 603-608. PMID 32641832 DOI: 10.1038/S41586-020-2470-Y  0.476
2019 Vicente-Gutierrez C, Bonora N, Bobo-Jimenez V, Jimenez-Blasco D, Lopez-Fabuel I, Fernandez E, Josephine C, Bonvento G, Enriquez JA, Almeida A, Bolaños JP. Astrocytic mitochondrial ROS modulate brain metabolism and mouse behaviour. Nature Metabolism. 1: 201-211. PMID 32694785 DOI: 10.1038/s42255-018-0031-6  0.426
2019 Moreno‐Cugnon L, Revuelta M, Arrizabalaga O, Colie S, Moreno‐Valladares M, Jimenez‐Blasco D, Gil‐Bea F, Llarena I, Bolaños JP, Nebreda AR, Matheu A. Neuronal p38α mediates age-associated neural stem cell exhaustion and cognitive decline. Aging Cell. 18. PMID 31560167 DOI: 10.1111/Acel.13044  0.361
2019 Burmistrova O, Olias-Arjona A, Lapresa R, Jimenez-Blasco D, Eremeeva T, Shishov D, Romanov S, Zakurdaeva K, Almeida A, Fedichev PO, Bolaños JP. Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in mice. Scientific Reports. 9: 11670. PMID 31406177 DOI: 10.1038/S41598-019-48196-Z  0.456
2018 Lapresa R, Agulla J, Sánchez-Morán I, Zamarreño R, Prieto E, Bolaños JP, Almeida A. Amyloid-ß promotes neurotoxicity by Cdk5-induced p53 stabilization. Neuropharmacology. PMID 30452955 DOI: 10.1016/J.Neuropharm.2018.11.019  0.387
2018 Rodríguez C, Ramos-Araque ME, Domínguez-Martínez M, Sobrino T, Sánchez-Morán I, Agulla J, Delgado-Esteban M, Gómez-Sánchez JC, Bolaños JP, Castillo J, Almeida A. Single-Nucleotide Polymorphism 309T>G in the MDM2 Promoter Determines Functional Outcome After Stroke. Stroke. 49: 2437-2444. PMID 30355102 DOI: 10.1161/Strokeaha.118.022529  0.339
2018 Fernandez-Fernandez S, Bobo-Jimenez V, Requejo-Aguilar R, Gonzalez-Fernandez S, Resch M, Carabias-Carrasco M, Ros J, Almeida A, Bolaños JP. Hippocampal neurons require a large pool of glutathione to sustain dendrite integrity and cognitive function. Redox Biology. 19: 52-61. PMID 30107295 DOI: 10.1016/J.Redox.2018.08.003  0.411
2018 López-Benito S, Sánchez-Sánchez J, Brito V, Calvo L, Lisa S, Torres-Valle M, Palko ME, Vicente-García C, Fernández-Fernández S, Bolaños JP, Ginés S, Tessarollo L, Arévalo JC. Regulation of BDNF release by ARMS/Kidins220 through modulation of Synaptotagmin-IV levels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29769266 DOI: 10.1523/Jneurosci.1653-17.2018  0.316
2018 FitzPatrick LM, Hawkins KE, Delhove JMKM, Fernandez E, Soldati C, Bullen LF, Nohturfft A, Waddington SN, Medina DL, Bolaños JP, McKay TR. NF-κB Activity Initiates Human ESC-Derived Neural Progenitor Cell Differentiation by Inducing a Metabolic Maturation Program. Stem Cell Reports. PMID 29681545 DOI: 10.1016/J.Stemcr.2018.03.015  0.302
2018 Bolaños JP, Jiménez-Blasco D, Lopez-Fabuel I, Vicente-Gutierrez C, Bonora N, Almeida A. Brain redox bioenergetics are determined by OXPHOS organization in neurons and astrocytes Free Radical Biology and Medicine. 120: S16. DOI: 10.1016/J.Freeradbiomed.2018.04.070  0.511
2018 Bolaños JP. OXPHOS organization in neurons and astrocytes regulates brain metabolism Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1859: e22. DOI: 10.1016/J.Bbabio.2018.09.069  0.399
2018 Hebert-Chatelain E, Jimenez-Blasco D, Busquets-Garcia A, Serrat R, Vicente-Gutierrez C, Lopez-Fabuel I, Resch M, Resel E, Saraswat D, Varilh M, Cannich A, Rio IB, Bellocchio L, Almeida A, Puente N, et al. Control of brain metabolism and behavior by cell-type specific mitochondrial CB1 receptors Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1859: e6. DOI: 10.1016/J.Bbabio.2018.09.020  0.358
2017 Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolaños JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Düssmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, et al. Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases. Cell Death and Differentiation. PMID 29229998 DOI: 10.1038/S41418-017-0020-4  0.427
2017 Barros LF, Bolaños JP, Bonvento G, Bouzier-Sore AK, Brown A, Hirrlinger J, Kasparov S, Kirchhoff F, Murphy AN, Pellerin L, Robinson MB, Weber B. Current technical approaches to brain energy metabolism. Glia. PMID 29110344 DOI: 10.1002/Glia.23248  0.362
2017 Lopez-Fabuel I, Martin-Martin L, Resch-Beusher M, Azkona G, Sanchez-Pernaute R, Bolaños JP. Mitochondrial respiratory chain disorganization in Parkinson's disease-relevant PINK1 and DJ1 mutants. Neurochemistry International. PMID 28408307 DOI: 10.1016/J.Neuint.2017.03.023  0.354
2017 Bobo-Jiménez V, Delgado-Esteban M, Angibaud J, Sánchez-Morán I, de la Fuente A, Yajeya J, Nägerl UV, Castillo J, Bolaños JP, Almeida A. APC/C(Cdh1)-Rock2 pathway controls dendritic integrity and memory. Proceedings of the National Academy of Sciences of the United States of America. PMID 28396402 DOI: 10.1073/Pnas.1616024114  0.344
2017 Peiró C, Romacho T, Azcutia V, Villalobos L, Fernández E, Bolaños JP, Moncada S, Sánchez-Ferrer CF. Erratum to: Inflammation, glucose, and vascular cell damage: the role of the pentose phosphate pathway. Cardiovascular Diabetology. 16: 25. PMID 28209202 DOI: 10.1186/S12933-017-0502-1  0.316
2017 Lopez-Fabuel I, Resch-Beusher M, Carabias-Carrasco M, Almeida A, Bolaños JP. Mitochondrial Complex I Activity is Conditioned by Supercomplex I-III2-IV Assembly in Brain Cells: Relevance for Parkinson's Disease. Neurochemical Research. PMID 28197854 DOI: 10.1007/S11064-017-2191-2  0.404
2017 Deuse T, Wang D, Hu X, Bhowmick N, Bolanos J, Tediashvili G, Alawi M, Hua X, Harris R, Spin J, Ali Z, Reichenspurner H, Robbins R, Tsao P, Schrepfer S. Rescue of Suppressed Mitochondrial Superoxide Alleviates Vascular Restenosis The Thoracic and Cardiovascular Surgeon. 65: S1-S110. DOI: 10.1055/S-0037-1598845  0.361
2016 Azkona G, López de Maturana R, Del Rio P, Sousa A, Vazquez N, Zubiarrain A, Jimenez-Blasco D, Bolaños JP, Morales B, Auburger G, Arbelo JM, Sánchez-Pernaute R. LRRK2 Expression Is Deregulated in Fibroblasts and Neurons from Parkinson Patients with Mutations in PINK1. Molecular Neurobiology. PMID 27975167 DOI: 10.1007/S12035-016-0303-7  0.371
2016 Fernandez E, Bolaños JP. α-Ketoglutarate dehydrogenase complex moonlighting: ROS signalling added to the list: An Editorial highlight for 'Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?' Journal of Neurochemistry. 139: 689-690. PMID 27882614 DOI: 10.1111/Jnc.13862  0.334
2016 Lopez-Fabuel I, Le Douce J, Logan A, James AM, Bonvento G, Murphy MP, Almeida A, Bolaños JP. Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes. Proceedings of the National Academy of Sciences of the United States of America. PMID 27799543 DOI: 10.1073/Pnas.1613701113  0.475
2016 Requejo-Aguilar R, Bolaños JP. Mitochondrial control of cell bioenergetics in Parkinson's disease. Free Radical Biology & Medicine. PMID 27091692 DOI: 10.1016/J.Freeradbiomed.2016.04.012  0.423
2016 Bolaños JP. Bioenergetics and redox adaptations of astrocytes to neuronal activity. Journal of Neurochemistry. PMID 26968531 DOI: 10.1111/Jnc.13486  0.502
2016 Hawkins KE, Joy S, Delhove JM, Kotiadis VN, Fernandez E, Fitzpatrick LM, Whiteford JR, King PJ, Bolanos JP, Duchen MR, Waddington SN, McKay TR. NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming. Cell Reports. PMID 26904936 DOI: 10.1016/J.Celrep.2016.02.003  0.398
2016 Bolaños JP. Bioenergetics and redox adaptations of astrocytes to neuronal activity Journal of Neurochemistry. DOI: 10.1111/jnc.13486  0.304
2015 Veas-Pérez de Tudela M, Maestre C, Delgado-Esteban M, Bolaños JP, Almeida A. Cdk5-mediated inhibition of APC/C-Cdh1 switches on the cyclin D1-Cdk4-pRb pathway causing aberrant S-phase entry of postmitotic neurons. Scientific Reports. 5: 18180. PMID 26658992 DOI: 10.1038/Srep18180  0.416
2015 Santofimia-Castaño P, Clea Ruy D, Garcia-Sanchez L, Jimenez-Blasco D, Fernandez-Bermejo M, Bolaños JP, Salido GM, Gonzalez A. Melatonin induces the expression of Nrf2-regulated antioxidant enzymes via PKC and Ca(2+) influx activation in mouse pancreatic acinar cells. Free Radical Biology & Medicine. FRBMD1500054. PMID 26163001 DOI: 10.1016/J.Freeradbiomed.2015.06.033  0.335
2015 Veas-Pérez de Tudela M, Delgado-Esteban M, Maestre C, Bobo-Jiménez V, Jiménez-Blasco D, Vecino R, Bolaños JP, Almeida A. Regulation of Bcl-xL-ATP Synthase Interaction by Mitochondrial Cyclin B1-Cyclin-Dependent Kinase-1 Determines Neuronal Survival. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 9287-301. PMID 26109654 DOI: 10.1523/Jneurosci.4712-14.2015  0.474
2015 Bouzier-Sore AK, Bolaños JP. Uncertainties in pentose-phosphate pathway flux assessment underestimate its contribution to neuronal glucose consumption: relevance for neurodegeneration and aging. Frontiers in Aging Neuroscience. 7: 89. PMID 26042035 DOI: 10.3389/Fnagi.2015.00089  0.37
2015 Jimenez-Blasco D, Santofimia-Castaño P, Gonzalez A, Almeida A, Bolaños JP. Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5-Nrf2 pathway. Cell Death and Differentiation. PMID 25909891 DOI: 10.1038/Cdd.2015.49  0.491
2015 Requejo-Aguilar R, Lopez-Fabuel I, Jimenez-Blasco D, Fernandez E, Almeida A, Bolaños JP. DJ1 represses glycolysis and cell proliferation by transcriptionally up-regulating Pink1. The Biochemical Journal. 467: 303-10. PMID 25670069 DOI: 10.1042/Bj20141025  0.358
2014 Requejo-Aguilar R, Lopez-Fabuel I, Fernandez E, Martins LM, Almeida A, Bolaños JP. PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism through HIF1. Nature Communications. 5: 4514. PMID 25058378 DOI: 10.1038/Ncomms5514  0.461
2014 Deuse T, Hua X, Wang D, Maegdefessel L, Heeren J, Scheja L, Bolaños JP, Rakovic A, Spin JM, Stubbendorff M, Ikeno F, Länger F, Zeller T, Schulte-Uentrop L, Stoehr A, et al. Dichloroacetate prevents restenosis in preclinical animal models of vessel injury. Nature. 509: 641-4. PMID 24747400 DOI: 10.1038/Nature13232  0.311
2014 Bolaños JP. TIGAR's promiscuity. The Biochemical Journal. 458: e5-7. PMID 24576095 DOI: 10.1042/Bj20140087  0.393
2014 Cisternas P, Silva-Alvarez C, Martínez F, Fernandez E, Ferrada L, Oyarce K, Salazar K, Bolaños JP, Nualart F. The oxidized form of vitamin C, dehydroascorbic acid, regulates neuronal energy metabolism. Journal of Neurochemistry. 129: 663-71. PMID 24460956 DOI: 10.1111/Jnc.12663  0.482
2014 Dunn L, Fairfield V, Daham S, Bolaños JP, Heales SJ. Pentose-phosphate pathway disruption in the pathogenesis of Parkinson's disease Translational Neuroscience. 5: 179-184. DOI: 10.2478/S13380-014-0221-Y  0.38
2013 Rodriguez-Rodriguez P, Fernandez E, Bolaños JP. Underestimation of the pentose-phosphate pathway in intact primary neurons as revealed by metabolic flux analysis. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 33: 1843-5. PMID 24064491 DOI: 10.1038/Jcbfm.2013.168  0.421
2013 Quintana-Cabrera R, Bolaños JP. Glutathione and γ-glutamylcysteine in hydrogen peroxide detoxification. Methods in Enzymology. 527: 129-44. PMID 23830629 DOI: 10.1016/B978-0-12-405882-8.00007-6  0.358
2013 Bolaños JP. Adapting glycolysis to cancer cell proliferation: the MAPK pathway focuses on PFKFB3. The Biochemical Journal. 452: e7-9. PMID 23725459 DOI: 10.1042/Bj20130560  0.334
2013 Davey GP, Bolaños JP. Peroxiredoxin 5 links mitochondrial redox signalling with calcium dynamics: impact on Parkinson's disease. Journal of Neurochemistry. 125: 332-3. PMID 23442153 DOI: 10.1111/Jnc.12171  0.308
2013 Rodriguez-Rodriguez P, Almeida A, Bolaños JP. Brain energy metabolism in glutamate-receptor activation and excitotoxicity: role for APC/C-Cdh1 in the balance glycolysis/pentose phosphate pathway. Neurochemistry International. 62: 750-6. PMID 23416042 DOI: 10.1016/J.Neuint.2013.02.005  0.443
2013 Quintana-Cabrera R, Bolaños JP. Glutathione and γ-glutamylcysteine in the antioxidant and survival functions of mitochondria. Biochemical Society Transactions. 41: 106-10. PMID 23356267 DOI: 10.1042/Bst20120252  0.407
2012 Filomeni G, Bolaños JP, Mastroberardino PG. Redox status and bioenergetics liaison in cancer and neurodegeneration. International Journal of Cell Biology. 2012: 659645. PMID 22997521 DOI: 10.1155/2012/659645  0.343
2012 Nisticò R, Bolaños JP, De Sarro GB. Integrating molecular mechanisms with synaptic plasticity in neurological disease. Molecular Neurobiology. 46: 545-6. PMID 22923365 DOI: 10.1007/S12035-012-8323-4  0.407
2012 Skytt DM, Klawonn AM, Stridh MH, Pajęcka K, Patruss Y, Quintana-Cabrera R, Bolaños JP, Schousboe A, Waagepetersen HS. siRNA knock down of glutamate dehydrogenase in astrocytes affects glutamate metabolism leading to extensive accumulation of the neuroactive amino acids glutamate and aspartate. Neurochemistry International. 61: 490-7. PMID 22542772 DOI: 10.1016/J.Neuint.2012.04.014  0.354
2012 Rodriguez-Rodriguez P, Fernandez E, Almeida A, Bolaños JP. Excitotoxic stimulus stabilizes PFKFB3 causing pentose-phosphate pathway to glycolysis switch and neurodegeneration. Cell Death and Differentiation. 19: 1582-9. PMID 22421967 DOI: 10.1038/Cdd.2012.33  0.488
2012 Fernandez-Fernandez S, Almeida A, Bolaños JP. Antioxidant and bioenergetic coupling between neurons and astrocytes. The Biochemical Journal. 443: 3-11. PMID 22417747 DOI: 10.1042/Bj20111943  0.504
2012 Quintana-Cabrera R, Fernandez-Fernandez S, Bobo-Jimenez V, Escobar J, Sastre J, Almeida A, Bolaños JP. γ-Glutamylcysteine detoxifies reactive oxygen species by acting as glutathione peroxidase-1 cofactor. Nature Communications. 3: 718. PMID 22395609 DOI: 10.1038/Ncomms1722  0.433
2012 Veas-Perez de Tudela M, Maestre C, Bolanos J, Almeida⁎ A. Excitotoxicity induces cyclin B1-Cdk1 activation leading to mitochondrial damage and oxidative stress in postmitotic neurons Free Radical Biology and Medicine. 53: S177. DOI: 10.1016/J.Freeradbiomed.2012.08.372  0.474
2012 Bolanos⁎ J, Quintana Cabrera R, Fernandez Fernandez S, Bobo Jimenez V, Escobar J, Sastre J, Almeida A. Neuroprotection by targeting antioxidant γ-glutamylcysteine to mitochondria Free Radical Biology and Medicine. 53: S7. DOI: 10.1016/J.Freeradbiomed.2012.08.082  0.326
2011 Gomez-Sanchez JC, Delgado-Esteban M, Rodriguez-Hernandez I, Sobrino T, Perez de la Ossa N, Reverte S, Bolaños JP, Gonzalez-Sarmiento R, Castillo J, Almeida A. The human Tp53 Arg72Pro polymorphism explains different functional prognosis in stroke. The Journal of Experimental Medicine. 208: 429-37. PMID 21357744 DOI: 10.1084/Jem.20101523  0.312
2010 Veas-Perez de Tudela M, Delgado-Esteban M, Cuende J, Bolaños JP, Almeida A. Human neuroblastoma cells with MYCN amplification are selectively resistant to oxidative stress by transcriptionally up-regulating glutamate cysteine ligase. Journal of Neurochemistry. 113: 819-25. PMID 20180881 DOI: 10.1111/J.1471-4159.2010.06648.X  0.374
2010 Bolaños JP, Heales SJ. Persistent mitochondrial damage by nitric oxide and its derivatives: neuropathological implications. Frontiers in Neuroenergetics. 2: 1. PMID 20162100 DOI: 10.3389/Neuro.14.001.2010  0.527
2010 Almeida A, Bolaños JP, Moncada S. E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation. Proceedings of the National Academy of Sciences of the United States of America. 107: 738-41. PMID 20080744 DOI: 10.1073/Pnas.0913668107  0.322
2010 Chiricozzi E, Fernandez-Fernandez S, Nardicchi V, Almeida A, Bolaños JP, Goracci G. Group IIA secretory phospholipase A2 (GIIA) mediates apoptotic death during NMDA receptor activation in rat primary cortical neurons. Journal of Neurochemistry. 112: 1574-83. PMID 20067579 DOI: 10.1111/J.1471-4159.2010.06567.X  0.465
2010 Bolaños JP, Almeida A, Moncada S. Glycolysis: a bioenergetic or a survival pathway? Trends in Biochemical Sciences. 35: 145-9. PMID 20006513 DOI: 10.1016/J.Tibs.2009.10.006  0.53
2010 Bolaños JP, Almeida A. The pentose-phosphate pathway in neuronal survival against nitrosative stress. Iubmb Life. 62: 14-8. PMID 19937972 DOI: 10.1002/Iub.280  0.468
2010 Vaz AR, Delgado-Esteban M, Brito MA, Bolaños JP, Brites D, Almeida A. Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid. Journal of Neurochemistry. 112: 56-65. PMID 19818102 DOI: 10.1111/J.1471-4159.2009.06429.X  0.493
2009 Minelli A, Conte C, Grottelli S, Bellezza I, Emiliani C, Bolaños JP. Cyclo(His-Pro) up-regulates heme oxygenase 1 via activation of Nrf2-ARE signalling. Journal of Neurochemistry. 111: 956-66. PMID 19735445 DOI: 10.1111/J.1471-4159.2009.06376.X  0.416
2009 Bolaños JP, Moro MA, Lizasoain I, Almeida A. Mitochondria and reactive oxygen and nitrogen species in neurological disorders and stroke: Therapeutic implications. Advanced Drug Delivery Reviews. 61: 1299-315. PMID 19716390 DOI: 10.1016/J.Addr.2009.05.009  0.41
2009 Herrero-Mendez A, Almeida A, Fernández E, Maestre C, Moncada S, Bolaños JP. The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1. Nature Cell Biology. 11: 747-52. PMID 19448625 DOI: 10.1038/Ncb1881  0.492
2009 Minelli A, Conte C, Grottelli S, Bellezza I, Cacciatore I, Bolaños JP. Cyclo(His-Pro) promotes cytoprotection by activating Nrf2-mediated up-regulation of antioxidant defence. Journal of Cellular and Molecular Medicine. 13: 1149-61. PMID 18373731 DOI: 10.1111/J.1582-4934.2008.00326.X  0.386
2008 Maestre C, Delgado-Esteban M, Gomez-Sanchez JC, Bolaños JP, Almeida A. Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity. The Embo Journal. 27: 2736-45. PMID 18818692 DOI: 10.1038/Emboj.2008.195  0.397
2008 Bolaños JP, Delgado-Esteban M, Herrero-Mendez A, Fernandez-Fernandez S, Almeida A. Regulation of glycolysis and pentose-phosphate pathway by nitric oxide: impact on neuronal survival. Biochimica Et Biophysica Acta. 1777: 789-93. PMID 18455501 DOI: 10.1016/J.Bbabio.2008.04.011  0.515
2008 Cuende J, Moreno S, Bolaños JP, Almeida A. Retinoic acid downregulates Rae1 leading to APC(Cdh1) activation and neuroblastoma SH-SY5Y differentiation. Oncogene. 27: 3339-44. PMID 18212744 DOI: 10.1038/Sj.Onc.1210987  0.312
2008 Bolanos JP, Delgado-Esteban M, Almeida A. S7/2 Modulation of glucose consuming pathways by nitric oxide in neurons: Impact on survival Biochimica Et Biophysica Acta (Bba) - Bioenergetics. 1777: S45. DOI: 10.1016/J.Bbabio.2008.05.179  0.424
2007 Bolaños JP, Herrero-Mendez A, Fernandez-Fernandez S, Almeida A. Linking glycolysis with oxidative stress in neural cells: a regulatory role for nitric oxide. Biochemical Society Transactions. 35: 1224-7. PMID 17956318 DOI: 10.1042/Bst0351224  0.518
2007 Diaz-Hernandez JI, Moncada S, Bolaños JP, Almeida A. Poly(ADP-ribose) polymerase-1 protects neurons against apoptosis induced by oxidative stress. Cell Death and Differentiation. 14: 1211-21. PMID 17347665 DOI: 10.1038/Sj.Cdd.4402117  0.471
2007 Delgado-Esteban M, Martin-Zanca D, Andres-Martin L, Almeida A, Bolaños JP. Inhibition of PTEN by peroxynitrite activates the phosphoinositide-3-kinase/Akt neuroprotective signaling pathway. Journal of Neurochemistry. 102: 194-205. PMID 17302912 DOI: 10.1111/J.1471-4159.2007.04450.X  0.425
2007 Bolaños JP, Almeida A. Nitric oxide in regulation of mitochondrial function, respiration, and glycolysis Handbook of Neurochemistry and Molecular Neurobiology: Brain Energetics. Integration of Molecular and Cellular Processes. 487-517. DOI: 10.1007/978-0-387-30411-3_18  0.313
2006 Moncada S, Bolaños JP. Nitric oxide, cell bioenergetics and neurodegeneration. Journal of Neurochemistry. 97: 1676-89. PMID 16805776 DOI: 10.1111/J.1471-4159.2006.03988.X  0.538
2006 Bolaños JP, Almeida A. Modulation of astroglial energy metabolism by nitric oxide. Antioxidants & Redox Signaling. 8: 955-65. PMID 16771685 DOI: 10.1089/Ars.2006.8.955  0.502
2005 Moro MA, Almeida A, Bolaños JP, Lizasoain I. Mitochondrial respiratory chain and free radical generation in stroke. Free Radical Biology & Medicine. 39: 1291-304. PMID 16257638 DOI: 10.1016/J.Freeradbiomed.2005.07.010  0.422
2005 Diaz-Hernandez JI, Almeida A, Delgado-Esteban M, Fernandez E, Bolaños JP. Knockdown of glutamate-cysteine ligase by small hairpin RNA reveals that both catalytic and modulatory subunits are essential for the survival of primary neurons. The Journal of Biological Chemistry. 280: 38992-9001. PMID 16183645 DOI: 10.1074/Jbc.M507065200  0.464
2005 Almeida A, Bolaños JP, Moreno S. Cdh1/Hct1-APC is essential for the survival of postmitotic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 8115-21. PMID 16148219 DOI: 10.1523/Jneurosci.1143-05.2005  0.422
2005 García O, Almeida A, Massieu L, Bolaños JP. Increased mitochondrial respiration maintains the mitochondrial membrane potential and promotes survival of cerebellar neurons in an endogenous model of glutamate receptor activation. Journal of Neurochemistry. 92: 183-90. PMID 15606907 DOI: 10.1111/J.1471-4159.2004.02851.X  0.742
2005 Almeida A, Cidad P, Delgado-Esteban M, Fernández E, García-Nogales P, Bolaños JP. Inhibition of mitochondrial respiration by nitric oxide: its role in glucose metabolism and neuroprotection. Journal of Neuroscience Research. 79: 166-71. PMID 15573411 DOI: 10.1002/Jnr.20281  0.542
2004 Cidad P, Almeida A, Bolaños JP. Inhibition of mitochondrial respiration by nitric oxide rapidly stimulates cytoprotective GLUT3-mediated glucose uptake through 5'-AMP-activated protein kinase. The Biochemical Journal. 384: 629-36. PMID 15320870 DOI: 10.1042/Bj20040886  0.421
2004 Bolaños JP, Cidad P, García-Nogales P, Delgado-Esteban M, Fernández E, Almeida A. Regulation of glucose metabolism by nitrosative stress in neural cells. Molecular Aspects of Medicine. 25: 61-73. PMID 15051317 DOI: 10.1016/J.Mam.2004.02.009  0.49
2004 Bolanos JP, García-Nogales P, Almeida A. Provoking neuroprotection by peroxynitrite. Current Pharmaceutical Design. 10: 867-77. PMID 15032690 DOI: 10.2174/1381612043452910  0.45
2004 Almeida A, Moncada S, Bolaños JP. Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway. Nature Cell Biology. 6: 45-51. PMID 14688792 DOI: 10.1038/Ncb1080  0.458
2003 Gegg ME, Beltran B, Salas-Pino S, Bolanos JP, Clark JB, Moncada S, Heales SJ. Differential effect of nitric oxide on glutathione metabolism and mitochondrial function in astrocytes and neurones: implications for neuroprotection/neurodegeneration? Journal of Neurochemistry. 86: 228-37. PMID 12807442 DOI: 10.1046/J.1471-4159.2003.01821.X  0.516
2003 Dello Russo C, Gavrilyuk V, Weinberg G, Almeida A, Bolanos JP, Palmer J, Pelligrino D, Galea E, Feinstein DL. Peroxisome proliferator-activated receptor gamma thiazolidinedione agonists increase glucose metabolism in astrocytes. The Journal of Biological Chemistry. 278: 5828-36. PMID 12486128 DOI: 10.1074/Jbc.M208132200  0.432
2003 García-Nogales P, Almeida A, Bolaños JP. Peroxynitrite protects neurons against nitric oxide-mediated apoptosis. A key role for glucose-6-phosphate dehydrogenase activity in neuroprotection. The Journal of Biological Chemistry. 278: 864-74. PMID 12414804 DOI: 10.1074/Jbc.M206835200  0.516
2003 Bolaños JP. Peroxynitrite as a novel neuroprotective intercellular signal Journal of Neurochemistry. 85: 9-9. DOI: 10.1046/J.1471-4159.85.S2.9_4.X  0.478
2002 Almeida A, Cidad P, Bolaños JP. Nitric oxide accounts for an increased glycolytic rate in activated astrocytes through a glycogenolysis-independent mechanism. Brain Research. 945: 131-4. PMID 12113960 DOI: 10.1016/S0006-8993(02)02877-9  0.411
2002 Almeida A, Delgado-Esteban M, Bolaños JP, Medina JM. Oxygen and glucose deprivation induces mitochondrial dysfunction and oxidative stress in neurones but not in astrocytes in primary culture. Journal of Neurochemistry. 81: 207-17. PMID 12064468 DOI: 10.1046/J.1471-4159.2002.00827.X  0.535
2002 Vega-Agapito V, Almeida A, Hatzoglou M, Bolaños JP. Peroxynitrite stimulates L-arginine transport system y(+) in glial cells. A potential mechanism for replenishing neuronal L-arginine. The Journal of Biological Chemistry. 277: 29753-9. PMID 12058042 DOI: 10.1074/Jbc.M203728200  0.328
2002 Heales SJ, Bolaños JP. Impairment of brain mitochondrial function by reactive nitrogen species: the role of glutathione in dictating susceptibility. Neurochemistry International. 40: 469-74. PMID 11850103 DOI: 10.1016/S0197-0186(01)00117-6  0.457
2001 Almeida A, Almeida J, Bolaños JP, Moncada S. Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection. Proceedings of the National Academy of Sciences of the United States of America. 98: 15294-9. PMID 11742096 DOI: 10.1073/Pnas.261560998  0.492
2001 Cidad P, Garcia-Nogales P, Almeida A, Bolaños JP. Expression of glucose transporter GLUT3 by endotoxin in cultured rat astrocytes: the role of nitric oxide. Journal of Neurochemistry. 79: 17-24. PMID 11595753 DOI: 10.1046/J.1471-4159.2001.00523.X  0.357
2001 Bolaños JP, García-Nogales P, Vega-Agapito V, Delgado-Esteban M, Cidad P, Almeida A. Nitric oxide-mediated mitochondrial impairment in neural cells: a role for glucose metabolism in neuroprotection. Progress in Brain Research. 132: 441-54. PMID 11545010 DOI: 10.1016/S0079-6123(01)32094-0  0.458
2001 Almeida A, Bolaños JP. A transient inhibition of mitochondrial ATP synthesis by nitric oxide synthase activation triggered apoptosis in primary cortical neurons. Journal of Neurochemistry. 77: 676-90. PMID 11299330 DOI: 10.1046/J.1471-4159.2001.00276.X  0.51
2001 Vásquez OL, Almeida A, Bolaños JP. Depletion of glutathione up-regulates mitochondrial complex I expression in glial cells. Journal of Neurochemistry. 76: 1593-6. PMID 11238744 DOI: 10.1046/J.1471-4159.2001.00223.X  0.462
2000 Delgado-Esteban M, Almeida A, Bolaños JP. D-Glucose prevents glutathione oxidation and mitochondrial damage after glutamate receptor stimulation in rat cortical primary neurons. Journal of Neurochemistry. 75: 1618-24. PMID 10987843 DOI: 10.1046/J.1471-4159.2000.0751618.X  0.449
1999 Vega-Agapito V, Almeida A, Heales SJ, Medina JM, Bolaños JP. Peroxynitrite anion stimulates arginine release from cultured rat astrocytes. Journal of Neurochemistry. 73: 1446-52. PMID 10501188 DOI: 10.1046/J.1471-4159.1999.0731446.X  0.406
1999 Almeida A, Bolaños JP, Medina JM. Nitric oxide mediates brain mitochondrial maturation immediately after birth. Febs Letters. 452: 290-4. PMID 10386608 DOI: 10.1016/S0014-5793(99)00628-6  0.425
1999 Bolaños JP, Almeida A. Roles of nitric oxide in brain hypoxia-ischemia. Biochimica Et Biophysica Acta. 1411: 415-36. PMID 10320673 DOI: 10.1016/S0005-2728(99)00030-4  0.436
1999 Brookes PS, Bolaños JP, Heales SJ. The assumption that nitric oxide inhibits mitochondrial ATP synthesis is correct. Febs Letters. 446: 261-3. PMID 10100854 DOI: 10.1016/S0014-5793(99)00217-3  0.42
1999 García-Nogales P, Almeida A, Fernández E, Medina JM, Bolaños JP. Induction of glucose-6-phosphate dehydrogenase by lipopolysaccharide contributes to preventing nitric oxide-mediated glutathione depletion in cultured rat astrocytes. Journal of Neurochemistry. 72: 1750-8. PMID 10098886 DOI: 10.1046/J.1471-4159.1999.721750.X  0.387
1999 Heales SJ, Bolaños JP, Stewart VC, Brookes PS, Land JM, Clark JB. Nitric oxide, mitochondria and neurological disease. Biochimica Et Biophysica Acta. 1410: 215-28. PMID 10076028 DOI: 10.1016/S0005-2728(98)00168-6  0.52
1999 Almeida A, Bolaños JP, Medina JM. Nitric oxide mediates glutamate-induced mitochondrial depolarization in rat cortical neurons. Brain Research. 816: 580-6. PMID 9878883 DOI: 10.1016/S0006-8993(98)01240-2  0.491
1998 Stewart VC, Taylor B, Bolaños JP, Land JM, Clark JB, Heales SJ. Astrocytic mitochondrial respiratory chain damage: effect on cellular ATP levels. Biochemical Society Transactions. 26: S346. PMID 10047860 DOI: 10.1042/Bst026S346  0.452
1998 Almeida A, Heales SJ, Bolaños JP, Medina JM. Glutamate neurotoxicity is associated with nitric oxide-mediated mitochondrial dysfunction and glutathione depletion. Brain Research. 790: 209-16. PMID 9593899 DOI: 10.1016/S0006-8993(98)00064-X  0.485
1998 Bolaños JP, Almeida A, Medina JM. Nitric oxide mediates brain mitochondrial damage during perinatal anoxia. Brain Research. 787: 117-22. PMID 9518575 DOI: 10.1016/S0006-8993(97)01530-8  0.43
1997 Bolaños JP, Almeida A, Fernández E, Medina JM, Land JM, Clark JB, Heales SJ. Potential mechanisms for nitric oxide-mediated impairment of brain mitochondrial energy metabolism. Biochemical Society Transactions. 25: 944-9. PMID 9388578 DOI: 10.1042/Bst0250944  0.439
1997 Bolaños JP, Peuchen S, Land JM, Clark JB, Heales SJ. Evaluation of the efficacy of potential therapeutic agents at protecting against nitric oxide synthase-mediated mitochondrial damage in activated astrocytes. Brain Research. Brain Research Protocols. 1: 258-62. PMID 9385063 DOI: 10.1016/S1385-299X(96)00039-6  0.52
1997 Peuchen S, Bolaños JP, Heales SJ, Almeida A, Duchen MR, Clark JB. Interrelationships between astrocyte function, oxidative stress and antioxidant status within the central nervous system. Progress in Neurobiology. 52: 261-81. PMID 9247965 DOI: 10.1016/S0301-0082(97)00010-5  0.437
1997 Bolaños JP, Medina JM. Effect of valproate on the metabolism of the central nervous system. Life Sciences. 60: 1933-42. PMID 9180347 DOI: 10.1016/S0024-3205(96)00687-X  0.339
1997 Bolaños JP, Almeida A, Stewart V, Peuchen S, Land JM, Clark JB, Heales SJ. Nitric oxide-mediated mitochondrial damage in the brain: mechanisms and implications for neurodegenerative diseases. Journal of Neurochemistry. 68: 2227-40. PMID 9166714 DOI: 10.1046/J.1471-4159.1997.68062227.X  0.541
1997 Bolaños JP, Almeida A, Fernández E, Medina JM, Land JM, Clark JB, Heales SJR. Impairment of astrocyte and neuronal energy metabolism by nitric oxide Biochemical Society Transactions. 25: 385S. DOI: 10.1042/Bst025385S  0.442
1997 Heales SJR, Land JM, Barker JE, Stewart VC, Brand MP, Clark JB, Bolaños JP. Nitric oxide and neurodegeneration Biochemical Society Transactions. 25: 384S. DOI: 10.1042/Bst025384Se  0.339
1996 Barker JE, Bolaños JP, Land JM, Clark JB, Heales SJ. Glutathione protects astrocytes from peroxynitrite-mediated mitochondrial damage: implications for neuronal/astrocytic trafficking and neurodegeneration. Developmental Neuroscience. 18: 391-6. PMID 8940610 DOI: 10.1159/000111432  0.496
1996 Bolaños JP, Heales SJ, Peuchen S, Barker JE, Land JM, Clark JB. Nitric oxide-mediated mitochondrial damage: a potential neuroprotective role for glutathione. Free Radical Biology & Medicine. 21: 995-1001. PMID 8937884 DOI: 10.1016/S0891-5849(96)00240-7  0.504
1996 Almeida A, González-Buitrago JM, Bolaños JP, Medina JM. Fuel utilization by early newborn brain is preserved under congenital hypothyroidism in the rat. Pediatric Research. 40: 410-4. PMID 8865277 DOI: 10.1203/00006450-199609000-00008  0.359
1996 Heales SJ, Bolaños JP, Clark JB. Glutathione depletion is accompanied by increased neuronal nitric oxide synthase activity. Neurochemical Research. 21: 35-9. PMID 8833221 DOI: 10.1007/Bf02527669  0.478
1996 Bolaños JP, Medina JM. Induction of nitric oxide synthase inhibits gap junction permeability in cultured rat astrocytes. Journal of Neurochemistry. 66: 2091-9. PMID 8780040 DOI: 10.1046/J.1471-4159.1996.66052091.X  0.336
1996 Vera B, Sánchez-Abarca LI, Bolaños JP, Medina JM. Inhibition of astrocyte gap junctional communication by ATP depletion is reversed by calcium sequestration. Febs Letters. 392: 225-8. PMID 8774849 DOI: 10.1016/0014-5793(96)00794-6  0.358
1996 Heales SJ, Bolaños JP, Brand MP, Clark JB, Land JM. Mitochondrial damage: an important feature in a number of inborn errors of metabolism? Journal of Inherited Metabolic Disease. 19: 140-2. PMID 8739950 DOI: 10.1007/Bf01799414  0.439
1996 Barker JE, Heales SJ, Cassidy A, Bolaños JP, Land JM, Clark JB. Depletion of brain glutathione results in a decrease of glutathione reductase activity; an enzyme susceptible to oxidative damage. Brain Research. 716: 118-22. PMID 8738227 DOI: 10.1016/0006-8993(96)00003-0  0.368
1995 Bolaños JP, Heales SJ, Land JM, Clark JB. Effect of peroxynitrite on the mitochondrial respiratory chain: differential susceptibility of neurones and astrocytes in primary culture. Journal of Neurochemistry. 64: 1965-72. PMID 7722484 DOI: 10.1046/J.1471-4159.1995.64051965.X  0.516
1995 Brown GC, Bolaños JP, Heales SJ, Clark JB. Nitric oxide produced by activated astrocytes rapidly and reversibly inhibits cellular respiration. Neuroscience Letters. 193: 201-4. PMID 7478183 DOI: 10.1016/0304-3940(95)11703-Y  0.42
1994 Bolaños JP, Medina JM. Inhibition of neonatal brain fuel utilization by valproate and E-delta 2-valproate is not a consequence of the stimulation of the gamma-aminobutyric acid shunt. Life Sciences. 55: PL397-402. PMID 7968221 DOI: 10.1016/0024-3205(94)00323-8  0.354
1994 Heales SJ, Bolaños JP, Land JM, Clark JB. Trolox protects mitochondrial complex IV from nitric oxide-mediated damage in astrocytes. Brain Research. 668: 243-5. PMID 7535655 DOI: 10.1016/0006-8993(94)90530-4  0.336
1994 Bolaños JP, Peuchen S, Heales SJ, Land JM, Clark JB. Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes. Journal of Neurochemistry. 63: 910-6. PMID 7519665 DOI: 10.1046/J.1471-4159.1994.63030910.X  0.457
1993 Bolaños JP, Medina JM. Effect of valproate on lipogenesis in neonatal rat brain. Biochemical Pharmacology. 45: 1283-8. PMID 8466548 DOI: 10.1016/0006-2952(93)90281-Z  0.316
1993 Bolaños JP, Medina JM. Lipogenesis from lactate in fetal rat brain during late gestation. Pediatric Research. 33: 66-71. PMID 8433864 DOI: 10.1203/00006450-199301000-00014  0.347
1993 Tabernero A, Bolaños JP, Medina JM. Lipogenesis from lactate in rat neurons and astrocytes in primary culture. The Biochemical Journal. 294: 635-8. PMID 8379917 DOI: 10.1042/Bj2940635  0.405
1991 Vicario C, Bolaños JP, Medina JM. The fate of lactate in isolated cells from early neonatal rat brain. Comparison with glucose and 3-hydroxybutyrate. Biochemical Society Transactions. 19: 141S. PMID 1889539 DOI: 10.1042/Bst019141S  0.306
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