Year |
Citation |
Score |
2024 |
Eglenen-Polat B, Kowash RR, Huang HC, Siteni S, Zhu M, Chen K, Bender ME, Mender I, Stastny V, Drapkin BJ, Raj P, Minna JD, Xu L, Shay JW, Akbay EA. A telomere-targeting drug depletes cancer initiating cells and promotes anti-tumor immunity in small cell lung cancer. Nature Communications. 15: 672. PMID 38253555 DOI: 10.1038/s41467-024-44861-8 |
0.317 |
|
2023 |
Rosso I, Jones-Weinert C, Rossiello F, Cabrini M, Brambillasca S, Munoz-Sagredo L, Lavagnino Z, Martini E, Tedone E, Garre' M, Aguado J, Parazzoli D, Mione M, Shay JW, Mercurio C, et al. Alternative lengthening of telomeres (ALT) cells viability is dependent on C-rich telomeric RNAs. Nature Communications. 14: 7086. PMID 37925537 DOI: 10.1038/s41467-023-42831-0 |
0.347 |
|
2023 |
Sohn EJ, Goralsky JA, Shay JW, Min J. The Molecular Mechanisms and Therapeutic Prospects of Alternative Lengthening of Telomeres (ALT). Cancers. 15. PMID 37046606 DOI: 10.3390/cancers15071945 |
0.333 |
|
2022 |
Muraki N, Yamada M, Doki H, Nakai R, Komeda K, Goto D, Kawabe N, Matsuoka K, Matsushima M, Kawabe T, Tanaka I, Morise M, Shay JW, Minna JD, Sato M. Resistance to mutant KRAS-induced senescence in a hTERT/Cdk4-immortalized normal human bronchial epithelial cell line. Experimental Cell Research. 113053. PMID 35149086 DOI: 10.1016/j.yexcr.2022.113053 |
0.314 |
|
2021 |
Sepe S, Rossiello F, Cancila V, Iannelli F, Matti V, Cicio G, Cabrini M, Marinelli E, Alabi BR, di Lillo A, Di Napoli A, Shay JW, Tripodo C, d'Adda di Fagagna F. DNA damage response at telomeres boosts the transcription of SARS-CoV-2 receptor ACE2 during aging. Embo Reports. e53658. PMID 34854526 DOI: 10.15252/embr.202153658 |
0.302 |
|
2021 |
Vessoni AT, Zhang T, Quinet A, Jeong HC, Munroe M, Wood M, Tedone E, Vindigni A, Shay JW, Greenberg RA, Batista LFZ. Telomere erosion in human pluripotent stem cells leads to ATR-mediated mitotic catastrophe. The Journal of Cell Biology. 220. PMID 33851958 DOI: 10.1083/jcb.202011014 |
0.349 |
|
2020 |
Mender I, Zhang A, Ren Z, Han C, Deng Y, Siteni S, Li H, Zhu J, Vemula A, Shay JW, Fu YX. Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity. Cancer Cell. PMID 32619407 DOI: 10.1016/J.Ccell.2020.05.020 |
0.395 |
|
2020 |
Sato M, Shay JW, Minna JD. Immortalized normal human lung epithelial cell models for studying lung cancer biology. Respiratory Investigation. PMID 32586780 DOI: 10.1016/J.Resinv.2020.04.005 |
0.418 |
|
2020 |
Abdisalaam S, Bhattacharya S, Mukherjee S, Sinha D, Srinivasan K, Zhu M, Akbay EA, Sadek HA, Shay JW, Aroumougame A. Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase. The Journal of Biological Chemistry. PMID 32540968 DOI: 10.1074/Jbc.Ra120.012962 |
0.375 |
|
2020 |
Schäfer C, Ju Y, Tak Y, Vazquez C, Han SJ, Tan E, Shay JW, Holmqvist M, Danuser G, Schopperle WM, Bubley G. TRA-1-60-positive/CD45 cells found in the peripheral blood of prostate cancer patients with metastatic disease - A proof-of-concept study. Heliyon. 6: e03263. PMID 32021935 DOI: 10.1016/J.Heliyon.2020.E03263 |
0.319 |
|
2020 |
Mender I, Batten K, Peyton M, Vemula A, Cornelius C, Girard L, Gao B, Minna JD, Shay JW. SLC43A3 is a Biomarker of Sensitivity to the Telomeric DNA Damage Mediator 6-Thio-2'-Deoxyguanosine. Cancer Research. PMID 31948943 DOI: 10.1158/0008-5472.Can-19-2257 |
0.369 |
|
2020 |
Peters-Hall JR, Min J, Tedone E, Sho S, Siteni S, Mender I, Shay JW. Proliferation of adult human bronchial epithelial cells without a telomere maintenance mechanism for over 200 population doublings. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 34: 386-398. PMID 31914653 DOI: 10.1096/Fj.201902376R |
0.415 |
|
2020 |
Zhang A, Mender I, Ren Z, Han C, Deng Y, Siteni S, Li H, Shay JW, Fu Y. Abstract 973: Telomere stress potentiates host STING-dependent anti-tumor immunity Immunology. 80: 973-973. DOI: 10.1158/1538-7445.Am2020-973 |
0.402 |
|
2019 |
Wang S, Huang J, Li C, Zhao L, Wong CC, Zhai J, Zhou Y, Deng W, Zeng Y, Gao S, Zhang Y, Wang G, Guan XY, Wei H, Wong SH, ... ... Shay JW, et al. MAP9 loss triggers chromosomal instability, initiates colorectal tumorigenesis and is associated with poor survival of colorectal cancer patients. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31662330 DOI: 10.1158/1078-0432.Ccr-19-1611 |
0.319 |
|
2019 |
Hao YH, Lafita-Navarro MC, Zacharias L, Borenstein-Auerbach N, Kim M, Barnes S, Kim J, Shay J, DeBerardinis RJ, Conacci-Sorrell M. Induction of LEF1 by MYC activates the WNT pathway and maintains cell proliferation. Cell Communication and Signaling : Ccs. 17: 129. PMID 31623618 DOI: 10.1186/S12964-019-0444-1 |
0.37 |
|
2019 |
Alabi BR, LaRanger R, Shay JW. Decellularized Mice Colons as Models to Study the Contribution of the Extracellular Matrix to Cell Behavior and Colon Cancer Progression. Acta Biomaterialia. PMID 31562987 DOI: 10.1016/J.Actbio.2019.09.033 |
0.408 |
|
2019 |
O'Hara R, Tedone E, Ludlow AT, Huang E, Arosio B, Mari D, Shay JW. Quantitative mitochondrial DNA copy number determination using droplet digital PCR with single cell resolution. Genome Research. PMID 31548359 DOI: 10.1101/Gr.250480.119 |
0.414 |
|
2019 |
Venkateswaran N, Lafita-Navarro MC, Hao YH, Kilgore JA, Perez-Castro L, Braverman J, Borenstein-Auerbach N, Kim M, Lesner NP, Mishra P, Brabletz T, Shay JW, DeBerardinis RJ, Williams NS, Yilmaz OH, et al. MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer. Genes & Development. PMID 31416966 DOI: 10.1101/Gad.327056.119 |
0.405 |
|
2019 |
Martin OCB, Bergonzini A, D'Amico F, Chen P, Shay JW, Dupuy J, Svensson M, Masucci MG, Frisan T. Infection with genotoxin-producing Salmonella enterica synergises with loss of the tumor suppressor APC in promoting genomic instability via the PI3K pathway in colonic epithelial cells. Cellular Microbiology. e13099. PMID 31414579 DOI: 10.1111/Cmi.13099 |
0.396 |
|
2019 |
Sayed ME, Cheng A, Yadav GP, Ludlow AT, Shay JW, Wright WE, Jiang QX. Catalysis-dependent inactivation of human telomerase and its reactivation by intracellular telomerase-activating factors (iTAFs). The Journal of Biological Chemistry. PMID 31186347 DOI: 10.1074/Jbc.Ra118.007234 |
0.645 |
|
2019 |
Min J, Wright WE, Shay JW. Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52. Genes & Development. PMID 31171703 DOI: 10.1101/Gad.324905.119 |
0.629 |
|
2019 |
Li Y, Zhou G, Bruno IG, Zhang N, Sho S, Tedone E, Lai TP, Cooke JP, Shay JW. Transient introduction of human telomerase mRNA improves hallmarks of progeria cells. Aging Cell. e12979. PMID 31152494 DOI: 10.1111/Acel.12979 |
0.449 |
|
2019 |
Wang W, Zhang L, Morlock L, Williams NS, Shay JW, De Brabander JK. Design and Synthesis of TASIN Analogues Specifically Targeting Colorectal Cancer Cell Lines with Mutant Adenomatous Polyposis Coli (APC). Journal of Medicinal Chemistry. PMID 31070915 DOI: 10.1021/Acs.Jmedchem.9B00532 |
0.365 |
|
2019 |
Sugarman ET, Zhang G, Shay JW. In perspective: An update on telomere targeting in cancer. Molecular Carcinogenesis. PMID 31062416 DOI: 10.1002/Mc.23035 |
0.462 |
|
2019 |
Zhang Z, Zhang T, Ge Y, Tang M, Ma W, Zhang Q, Gong S, Wright WE, Shay J, Liu H, Zhao Y. 2D gel electrophoresis reveals dynamics of t-loop formation during the cell cycle and t-loop in maintenance regulated by heterochromatin state. The Journal of Biological Chemistry. PMID 30819801 DOI: 10.1074/Jbc.Ra119.007677 |
0.594 |
|
2019 |
Shay JW, Wright WE. Telomeres and telomerase: three decades of progress. Nature Reviews. Genetics. PMID 30760854 DOI: 10.1038/S41576-019-0099-1 |
0.651 |
|
2018 |
Sayed ME, Yuan L, Robin JD, Tedone E, Batten K, Dahlson N, Wright WE, Shay JW, Ludlow AT. NOVA1 directs PTBP1 to hTERT pre-mRNA and promotes telomerase activity in cancer cells. Oncogene. PMID 30568224 DOI: 10.1038/S41388-018-0639-8 |
0.659 |
|
2018 |
Zhang G, Shay JW. Inducing rapid telomere irreparable damage in telomerase-expressing cancers. Oncotarget. 9: 35803-35804. PMID 30533193 DOI: 10.18632/Oncotarget.26317 |
0.384 |
|
2018 |
Tedone E, Huang E, O'Hara R, Batten K, Ludlow AT, Lai TP, Arosio B, Mari D, Wright WE, Shay JW. Telomere length and telomerase activity in T cells are biomarkers of high-performing centenarians. Aging Cell. e12859. PMID 30488553 DOI: 10.1111/Acel.12859 |
0.61 |
|
2018 |
Mukherjee AK, Sharma S, Sengupta S, Saha D, Kumar P, Hussain T, Srivastava V, Roy SD, Shay JW, Chowdhury S. Telomere length-dependent transcription and epigenetic modifications in promoters remote from telomere ends. Plos Genetics. 14: e1007782. PMID 30439955 DOI: 10.1371/Journal.Pgen.1007782 |
0.41 |
|
2018 |
Ludlow AT, Wong MS, Robin JD, Batten K, Yuan L, Lai TP, Dahlson N, Zhang L, Mender I, Tedone E, Sayed ME, Wright WE, Shay JW. NOVA1 regulates hTERT splicing and cell growth in non-small cell lung cancer. Nature Communications. 9: 3112. PMID 30082712 DOI: 10.1038/S41467-018-05582-X |
0.658 |
|
2018 |
Mender I, LaRanger R, Luitel K, Peyton M, Girard L, Lai TP, Batten K, Cornelius C, Dalvi MP, Ramirez M, Du W, Wu LF, Altschuler SJ, Brekken R, Martinez ED, ... ... Shay JW, et al. Telomerase-Mediated Strategy for Overcoming Non-Small Cell Lung Cancer Targeted Therapy and Chemotherapy Resistance. Neoplasia (New York, N.Y.). 20: 826-837. PMID 30015158 DOI: 10.1016/J.Neo.2018.06.002 |
0.623 |
|
2018 |
Kim SB, Zhang L, Yoon J, Lee J, Min J, Li W, Grishin NV, Moon YA, Wright WE, Shay JW. Truncated APC Mutation Induces Asef Activated Golgi Fragmentation. Molecular and Cellular Biology. PMID 29866653 DOI: 10.1128/Mcb.00135-18 |
0.66 |
|
2018 |
Peters-Hall JR, Coquelin ML, Torres MJ, LaRanger R, Alabi BR, Sho S, Calva-Moreno JF, Thomas PJ, Shay JW. Long-term Culture and Cloning of Primary Human Bronchial Basal Cells that Maintain Multipotent Differentiation Capacity and CFTR Channel Function. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 29722564 DOI: 10.1152/Ajplung.00355.2017 |
0.387 |
|
2018 |
Ludlow AT, Shelton D, Wright WE, Shay JW. ddTRAP: A Method for Sensitive and Precise Quantification of Telomerase Activity. Methods in Molecular Biology (Clifton, N.J.). 1768: 513-529. PMID 29717462 DOI: 10.1007/978-1-4939-7778-9_29 |
0.67 |
|
2018 |
Reyes-Uribe P, Adrianzen-Ruesta MP, Deng Z, Echevarria-Vargas I, Mender I, Saheb S, Liu Q, Altieri DC, Murphy ME, Shay JW, Lieberman PM, Villanueva J. Exploiting TERT dependency as a therapeutic strategy for NRAS-mutant melanoma. Oncogene. PMID 29695835 DOI: 10.1038/S41388-018-0247-7 |
0.345 |
|
2018 |
Sengupta S, Sobo M, Lee K, Senthil Kumar S, White AR, Mender I, Fuller C, Chow LM, Fouladi M, Shay JW, Drissi R. Induced Telomere Damage to Treat Telomerase Expressing Therapy-Resistant Pediatric Brain Tumors. Molecular Cancer Therapeutics. PMID 29654065 DOI: 10.1158/1535-7163.Mct-17-0792 |
0.384 |
|
2018 |
Zhang L, Kim SB, Luitel K, Shay JW. Cholesterol Depletion by TASIN-1 Induces Apoptotic Cell Death through the ER Stress/ROS/JNK Signaling in Colon Cancer Cells. Molecular Cancer Therapeutics. PMID 29467273 DOI: 10.1158/1535-7163.Mct-17-0887 |
0.406 |
|
2018 |
Walser TC, Jing Z, Tran LM, Lin YQ, Yakobian N, Wang G, Krysan K, Zhu LX, Sharma S, Lee MH, Belperio JA, Ooi AT, Gomperts BN, Shay JW, Larsen JE, et al. Silencing the Snail-dependent RNA splice regulator ESRP1 drives malignant transformation of human pulmonary epithelial cells. Cancer Research. PMID 29431637 DOI: 10.1158/0008-5472.Can-17-0315 |
0.399 |
|
2018 |
Lai TP, Wright WE, Shay JW. Comparison of telomere length measurement methods. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 373. PMID 29335378 DOI: 10.1098/Rstb.2016.0451 |
0.641 |
|
2018 |
Aviv A, Shay JW. Reflections on telomere dynamics and ageing-related diseases in humans. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 373. PMID 29335375 DOI: 10.1098/Rstb.2016.0436 |
0.375 |
|
2017 |
Shay JW. Telomeres and aging. Current Opinion in Cell Biology. 52: 1-7. PMID 29253739 DOI: 10.1016/J.Ceb.2017.12.001 |
0.399 |
|
2017 |
Kim W, Shay JW. Long-range telomere regulation of gene expression: Telomere looping and telomere position effect over long distances (TPE-OLD). Differentiation; Research in Biological Diversity. 99: 1-9. PMID 29197683 DOI: 10.1016/J.Diff.2017.11.005 |
0.496 |
|
2017 |
Lai TP, Zhang N, Noh J, Mender I, Tedone E, Huang E, Wright WE, Danuser G, Shay JW. A method for measuring the distribution of the shortest telomeres in cells and tissues. Nature Communications. 8: 1356. PMID 29116081 DOI: 10.1038/S41467-017-01291-Z |
0.646 |
|
2017 |
Shay JW. New insights into melanoma development. Science (New York, N.Y.). 357: 1358-1359. PMID 28963245 DOI: 10.1126/Science.Aao6963 |
0.424 |
|
2017 |
Saunier E, Antonio S, Regazzetti A, Auzeil N, Laprévote O, Shay JW, Coumoul X, Barouki R, Benelli C, Huc L, Bortoli S. Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells. Scientific Reports. 7: 6945. PMID 28761044 DOI: 10.1038/S41598-017-07006-0 |
0.342 |
|
2017 |
Min J, Wright WE, Shay JW. Alternative Lengthening of Telomeres Mediated by Mitotic DNA Synthesis Engages Break-Induced Replication Processes. Molecular and Cellular Biology. PMID 28760773 DOI: 10.1128/Mcb.00226-17 |
0.668 |
|
2017 |
Huang EE, Tedone E, O'Hara R, Cornelius C, Lai TP, Ludlow A, Wright WE, Shay JW. The Maintenance of Telomere Length in CD28+ T Cells During T Lymphocyte Stimulation. Scientific Reports. 7: 6785. PMID 28754961 DOI: 10.1038/S41598-017-05174-7 |
0.63 |
|
2017 |
LaRanger R, Peters-Hall JR, Coquelin M, Alabi BR, Chen C, Wright WE, Shay J. Reconstituting Mouse Lungs with Conditionally Reprogrammed Human Bronchial Epithelial Cells. Tissue Engineering. Part A. PMID 28726588 DOI: 10.1089/Ten.Tea.2017.0114 |
0.589 |
|
2017 |
Aviv A, Anderson JJ, Shay JW. Mutations, Cancer and the Telomere Length Paradox. Trends in Cancer. 3: 253-258. PMID 28718437 DOI: 10.1016/J.Trecan.2017.02.005 |
0.406 |
|
2017 |
Zhang L, Shay JW. Multiple Roles of APC and its Therapeutic Implications in Colorectal Cancer. Journal of the National Cancer Institute. 109. PMID 28423402 DOI: 10.1093/Jnci/Djw332 |
0.332 |
|
2017 |
Zhao Y, Shay JW, Wright WE. Telomere Terminal G/C Strand Synthesis: Measuring Telomerase Action and C-Rich Fill-In. Methods in Molecular Biology (Clifton, N.J.). 1587: 71-82. PMID 28324499 DOI: 10.1007/978-1-4939-6892-3_7 |
0.652 |
|
2017 |
Zhao Y, Shay JW, Wright WE. Telomere G-Rich Overhang Length Measurement: DSN Method. Methods in Molecular Biology (Clifton, N.J.). 1587: 55-62. PMID 28324497 DOI: 10.1007/978-1-4939-6892-3_5 |
0.61 |
|
2017 |
Jafri MA, Al-Qahtani MH, Shay JW. Role of miRNAs in human cancer metastasis: implications for therapeutic intervention. Seminars in Cancer Biology. PMID 28188828 DOI: 10.1016/J.Semcancer.2017.02.004 |
0.329 |
|
2017 |
Liu J, Hu J, Ludlow AT, Pham JT, Shay JW, Rothstein JD, Corey DR. c9orf72 Disease-Related Foci Are Each Composed of One Mutant Expanded Repeat RNA. Cell Chemical Biology. PMID 28132891 DOI: 10.1016/J.Chembiol.2016.12.018 |
0.302 |
|
2017 |
Min J, Wright WE, Shay JW. Alternative lengthening of telomeres can be maintained by preferential elongation of lagging strands. Nucleic Acids Research. PMID 28082393 DOI: 10.1093/Nar/Gkw1295 |
0.698 |
|
2016 |
Gao B, Huang C, Kernstine K, Pelekanou V, Kluger Y, Jiang T, Peters-Hall JR, Coquelin M, Girard L, Zhang W, Huffman K, Oliver D, Kinose F, Haura E, Teer JK, ... ... Shay JW, et al. Non-malignant respiratory epithelial cells preferentially proliferate from resected non-small cell lung cancer specimens cultured under conditionally reprogrammed conditions. Oncotarget. PMID 28052041 DOI: 10.18632/Oncotarget.14366 |
0.386 |
|
2016 |
Kim W, Ludlow AT, Min J, Robin JD, Stadler G, Mender I, Lai TP, Zhang N, Wright WE, Shay JW. Regulation of the Human Telomerase Gene TERT by Telomere Position Effect-Over Long Distances (TPE-OLD): Implications for Aging and Cancer. Plos Biology. 14: e2000016. PMID 27977688 DOI: 10.1371/Journal.Pbio.2000016 |
0.69 |
|
2016 |
Min J, Shay JW. TERT Promoter Mutations Enhance Telomerase Activation by Long-Range Chromatin Interactions. Cancer Discovery. 6: 1212-1214. PMID 27807101 DOI: 10.1158/2159-8290.Cd-16-1050 |
0.384 |
|
2016 |
Zhang L, Theodoropoulos PC, Eskiocak U, Wang W, Moon YA, Posner B, Williams NS, Wright WE, Kim SB, Nijhawan D, De Brabander JK, Shay JW. Selective targeting of mutant adenomatous polyposis coli (APC) in colorectal cancer. Science Translational Medicine. 8: 361ra140. PMID 27798265 DOI: 10.1126/Scitranslmed.Aaf8127 |
0.634 |
|
2016 |
Holohan B, Kim W, Lai TP, Hoshiyama H, Zhang N, Alazami AM, Wright WE, Meyn MS, Alkuraya FS, Shay JW. Impaired telomere maintenance in Alazami syndrome patients with LARP7 deficiency. Bmc Genomics. 17: 749. PMID 27766953 DOI: 10.1186/S12864-016-3093-4 |
0.582 |
|
2016 |
Mimmler M, Peter S, Kraus A, Stroh S, Nikolova T, Seiwert N, Hasselwander S, Neitzel C, Haub J, Monien BH, Nicken P, Steinberg P, Shay JW, Kaina B, Fahrer J. DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP. Nucleic Acids Research. PMID 27599846 DOI: 10.1093/Nar/Gkw791 |
0.349 |
|
2016 |
Druliner BR, Ruan X, Johnson R, Grill D, O'Brien D, Lai TP, Rashtak S, Felmlee-Devine D, Washechek-Aletto J, Malykh A, Smyrk T, Oberg A, Liu H, Shay JW, Ahlquist DA, et al. Time Lapse to Colorectal Cancer: Telomere Dynamics Define the Malignant Potential of Polyps. Clinical and Translational Gastroenterology. 7: e188. PMID 27584834 DOI: 10.1038/Ctg.2016.48 |
0.375 |
|
2016 |
El-Ashmawy M, Coquelin M, Luitel K, Batten K, Shay JW. Organotypic culture in three dimensions prevents radiation-induced transformation in human lung epithelial cells. Scientific Reports. 6: 31669. PMID 27539227 DOI: 10.1038/Srep31669 |
0.336 |
|
2016 |
Padanad MS, Konstantinidou G, Venkateswaran N, Melegari M, Rindhe S, Mitsche M, Yang C, Batten K, Huffman KE, Liu J, Tang X, Rodriguez-Canales J, Kalhor N, Shay JW, Minna JD, et al. Fatty Acid Oxidation Mediated by Acyl-CoA Synthetase Long Chain 3 Is Required for Mutant KRAS Lung Tumorigenesis. Cell Reports. PMID 27477280 DOI: 10.1016/J.Celrep.2016.07.009 |
0.326 |
|
2016 |
Liu N, Ding D, Hao W, Yang F, Wu X, Wang M, Xu X, Ju Z, Liu JP, Song Z, Shay JW, Guo Y, Cong YS. hTERT promotes tumor angiogenesis by activating VEGF via interactions with the Sp1 transcription factor. Nucleic Acids Research. PMID 27325744 DOI: 10.1093/Nar/Gkw549 |
0.306 |
|
2016 |
Jafri MA, Ansari SA, Alqahtani MH, Shay JW. Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies. Genome Medicine. 8: 69. PMID 27323951 DOI: 10.1186/S13073-016-0324-X |
0.477 |
|
2016 |
Lai TP, Wright WE, Shay JW. Generation of digoxigenin-incorporated probes to enhance DNA detection sensitivity. Biotechniques. 60: 306-9. PMID 27286808 DOI: 10.2144/000114427 |
0.614 |
|
2016 |
Opresko PL, Shay JW. Telomere-Associated Aging Disorders. Ageing Research Reviews. PMID 27215853 DOI: 10.1016/J.Arr.2016.05.009 |
0.352 |
|
2016 |
Frink RE, Peyton M, Schiller JH, Gazdar AF, Shay JW, Minna JD. Telomerase inhibitor imetelstat has preclinical activity across the spectrum of non-small cell lung cancer oncogenotypes in a telomere length dependent manner. Oncotarget. PMID 27192120 DOI: 10.18632/Oncotarget.9335 |
0.437 |
|
2016 |
Robin JD, Ludlow AT, LaRanger R, Wright WE, Shay JW. Comparison of DNA Quantification Methods for Next Generation Sequencing. Scientific Reports. 6: 24067. PMID 27048884 DOI: 10.1038/Srep24067 |
0.569 |
|
2016 |
Graillot V, Dormoy I, Dupuy J, Shay JW, Huc L, Mirey G, Vignard J. Genotoxicity of Cytolethal Distending Toxin (CDT) on Isogenic Human Colorectal Cell Lines: Potential Promoting Effects for Colorectal Carcinogenesis. Frontiers in Cellular and Infection Microbiology. 6: 34. PMID 27047802 DOI: 10.3389/Fcimb.2016.00034 |
0.426 |
|
2016 |
Shay JW. Role of Telomeres and Telomerase in Aging and Cancer. Cancer Discovery. PMID 27029895 DOI: 10.1158/2159-8290.Cd-16-0062 |
0.418 |
|
2016 |
Erzinger MM, Bovet C, Hecht KM, Senger S, Winiker P, Sobotzki N, Cristea S, Beerenwinkel N, Shay JW, Marra G, Wollscheid B, Sturla SJ. Sulforaphane Preconditioning Sensitizes Human Colon Cancer Cells towards the Bioreductive Anticancer Prodrug PR-104A. Plos One. 11: e0150219. PMID 26950072 DOI: 10.1371/Journal.Pone.0150219 |
0.405 |
|
2016 |
Bhagwandin VJ, Bishop JM, Wright WE, Shay JW. The Metastatic Potential and Chemoresistance of Human Pancreatic Cancer Stem Cells. Plos One. 11: e0148807. PMID 26859746 DOI: 10.1371/Journal.Pone.0148807 |
0.638 |
|
2016 |
Padanad MS, Konstantinidou G, Yang C, Melegari M, Venkateswaran N, Batten K, Huffman KE, Shay JW, Minna JD, DeBerardinis RJ, Scaglioni PP. Abstract B22: Acyl-CoA synthetase long-chain family member 3 dependent lipid homeostasis is required for mutant KRAS driven lung cancer Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Metca15-B22 |
0.39 |
|
2016 |
Walser TC, Jing Z, Tran L, Lin Y, Zhu L, Sharma S, Ooi A, Gomperts BN, Shay JW, Larsen JE, Gao B, Minna JD, Fishbein MC, Dubinett SM. Abstract 5170: Snail-dependent ESRP1 silencing drives malignant conversion of human pulmonary epithelial cells Cancer Research. 76: 5170-5170. DOI: 10.1158/1538-7445.Am2016-5170 |
0.366 |
|
2016 |
Chen J, Yao Z, Chen J, Gi YJ, Jeong YS, Jogunoori W, Belkin M, Mishra B, White J, Mitra A, Li S, Finegold M, Davila M, Shay J, Machida K, et al. Abstract 2540: Disruption of a TGF-β-CTCF regulated pathway leads to cancer stem cells Cancer Research. 76: 2540-2540. DOI: 10.1158/1538-7445.Am2016-2540 |
0.369 |
|
2015 |
Mender I, Shay JW. Telomere Restriction Fragment (TRF) Analysis. Bio-Protocol. 5. PMID 27500189 |
0.408 |
|
2015 |
Mender I, Shay JW. Telomerase Repeated Amplification Protocol (TRAP). Bio-Protocol. 5. PMID 27182535 |
0.364 |
|
2015 |
Niwa O, Barcellos-Hoff MH, Globus RK, Harrison JD, Hendry JH, Jacob P, Martin MT, Seed TM, Shay JW, Story MD, Suzuki K, Yamashita S. ICRP Publication 131: Stem Cell Biology with Respect to Carcinogenesis Aspects of Radiological Protection. Annals of the Icrp. 44: 7-357. PMID 26637346 DOI: 10.1177/0146645315595585 |
0.384 |
|
2015 |
Kim SB, Bozeman RG, Kaisani A, Kim W, Zhang L, Richardson JA, Wright WE, Shay JW. Radiation promotes colorectal cancer initiation and progression by inducing senescence-associated inflammatory responses. Oncogene. PMID 26477319 DOI: 10.1038/Onc.2015.395 |
0.35 |
|
2015 |
Mender I, Gryaznov S, Shay JW. A novel telomerase substrate precursor rapidly induces telomere dysfunction in telomerase positive cancer cells but not telomerase silent normal cells. Oncoscience. 2: 693-5. PMID 26425659 |
0.356 |
|
2015 |
Robin JD, Ludlow AT, Batten K, Gaillard MC, Stadler G, Magdinier F, Wright WE, Shay JW. SORBS2 transcription is activated by telomere position effect-over long distance upon telomere shortening in muscle cells from patients with facioscapulohumeral dystrophy. Genome Research. PMID 26359233 DOI: 10.1101/Gr.190660.115 |
0.625 |
|
2015 |
Holohan B, Hagiopian MM, Lai TP, Huang E, Friedman DR, Wright WE, Shay JW. Perifosine as a potential novel anti-telomerase therapy. Oncotarget. 6: 21816-26. PMID 26307677 DOI: 10.18632/Oncotarget.5200 |
0.647 |
|
2015 |
Meyer CJ, Krauth M, Wick MJ, Shay JW, Gellert G, De Brabander JK, Northcote PT, Miller JH. Peloruside A inhibits growth of human lung and breast tumor xenografts in an athymic nu/nu mouse model. Molecular Cancer Therapeutics. PMID 26056149 DOI: 10.1158/1535-7163.Mct-15-0167 |
0.379 |
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2015 |
Holohan B, De Meyer T, Batten K, Mangino M, Hunt SC, Bekaert S, De Buyzere ML, Rietzschel ER, Spector TD, Wright WE, Shay JW. Decreasing initial telomere length in humans intergenerationally understates age-associated telomere shortening. Aging Cell. PMID 25952108 DOI: 10.1111/Acel.12347 |
0.595 |
|
2015 |
Kulak O, Chen H, Holohan B, Wu X, He H, Borek D, Otwinowski Z, Yamaguchi K, Garofalo LA, Ma Z, Wright W, Chen C, Shay JW, Zhang X, Lum L. Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells. Molecular and Cellular Biology. 35: 2425-35. PMID 25939383 DOI: 10.1128/Mcb.00392-15 |
0.638 |
|
2015 |
Zhang L, Kim S, Jia G, Buhmeida A, Dallol A, Wright WE, Fornace AJ, Al-Qahtani M, Shay JW. Exome Sequencing of Normal and Isogenic Transformed Human Colonic Epithelial Cells (HCECs) Reveals Novel Genes Potentially Involved in the Early Stages of Colorectal Tumorigenesis. Bmc Genomics. 16: S8. PMID 25923178 DOI: 10.1186/1471-2164-16-S1-S8 |
0.64 |
|
2015 |
Pandita RK, Chow TT, Udayakumar D, Bain AL, Cubeddu L, Hunt CR, Shi W, Horikoshi N, Zhao Y, Wright WE, Khanna KK, Shay JW, Pandita TK. Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs. Cancer Research. 75: 858-69. PMID 25589350 DOI: 10.1158/0008-5472.Can-14-2289 |
0.655 |
|
2015 |
Mender I, Gryaznov S, Dikmen ZG, Wright WE, Shay JW. Induction of telomere dysfunction mediated by the telomerase substrate precursor 6-thio-2'-deoxyguanosine. Cancer Discovery. 5: 82-95. PMID 25516420 DOI: 10.1158/2159-8290.Cd-14-0609 |
0.713 |
|
2015 |
Schafer AC, Discoll M, Mohan A, Ludlow A, Burford W, Shay JW, Danuser G. Abstract 5102: Differential levels of mutated Kras drive lung cancer cell motility and morphology via a hypoxia-sensitive FAK/Erk/Myosin II signaling pathway Cancer Research. 75: 5102-5102. DOI: 10.1158/1538-7445.Am2015-5102 |
0.412 |
|
2015 |
Chen J, Chen J, Yao Z, Jogunoori W, Mishra B, Herlong FH, Jeong YS, Mistry NA, Zhang J, Su X, Rashid A, Davila M, Stroehlein JR, Shay JW, Mishra L. Abstract 2334: Disruption of TGF-β-regulated CTCF suppression of telomerase links a human stem cell disorder to tumorigenesis Cancer Research. 75: 2334-2334. DOI: 10.1158/1538-7445.Am2015-2334 |
0.333 |
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2015 |
Chen J, Chen J, Yao Z, Jogunoori W, Mishra B, Herlong F, Jeong YS, Mistry NA, Zhang J, Su X, Rashid A, Davila ML, Stroehlein JR, Shay JW, Mishra L. 532 A TGF-β-CTCF Regulated Pathway Suppresses Stem Cell Associated Tumor Progression Gastroenterology. 148: S-106. DOI: 10.1016/S0016-5085(15)30364-4 |
0.309 |
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2014 |
El-Ashmawy M, Delgado O, Cardentey A, Wright WE, Shay JW. CDDO-Me protects normal lung and breast epithelial cells but not cancer cells from radiation. Plos One. 9: e115600. PMID 25536195 DOI: 10.1371/Journal.Pone.0115600 |
0.646 |
|
2014 |
Robin JD, Ludlow AT, Batten K, Magdinier F, Stadler G, Wagner KR, Shay JW, Wright WE. Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances. Genes & Development. 28: 2464-76. PMID 25403178 DOI: 10.1101/Gad.251041.114 |
0.654 |
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2014 |
Wong MS, Wright WE, Shay JW. Alternative splicing regulation of telomerase: a new paradigm? Trends in Genetics : Tig. 30: 430-8. PMID 25172021 DOI: 10.1016/J.Tig.2014.07.006 |
0.604 |
|
2014 |
Shao C, Sullivan JP, Girard L, Augustyn A, Yenerall P, Rodriguez-Canales J, Liu H, Behrens C, Shay JW, Wistuba II, Minna JD. Essential role of aldehyde dehydrogenase 1A3 for the maintenance of non-small cell lung cancer stem cells is associated with the STAT3 pathway. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 4154-66. PMID 24907115 DOI: 10.1158/1078-0432.Ccr-13-3292 |
0.368 |
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2014 |
Ludlow AT, Robin JD, Sayed M, Litterst CM, Shelton DN, Shay JW, Wright WE. Quantitative telomerase enzyme activity determination using droplet digital PCR with single cell resolution. Nucleic Acids Research. 42: e104. PMID 24861623 DOI: 10.1093/Nar/Gku439 |
0.653 |
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2014 |
Kaisani A, Delgado O, Fasciani G, Kim SB, Wright WE, Minna JD, Shay JW. Branching morphogenesis of immortalized human bronchial epithelial cells in three-dimensional culture. Differentiation; Research in Biological Diversity. 87: 119-26. PMID 24830354 DOI: 10.1016/J.Diff.2014.02.003 |
0.624 |
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2014 |
Holohan B, Wright WE, Shay JW. Cell biology of disease: Telomeropathies: an emerging spectrum disorder. The Journal of Cell Biology. 205: 289-99. PMID 24821837 DOI: 10.1083/Jcb.201401012 |
0.572 |
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2014 |
Farooqi AS, Dagg RA, Choi LM, Shay JW, Reynolds CP, Lau LM. Alternative lengthening of telomeres in neuroblastoma cell lines is associated with a lack of MYCN genomic amplification and with p53 pathway aberrations. Journal of Neuro-Oncology. 119: 17-26. PMID 24792489 DOI: 10.1007/S11060-014-1456-8 |
0.438 |
|
2014 |
Singel SM, Cornelius C, Zaganjor E, Batten K, Sarode VR, Buckley DL, Peng Y, John GB, Li HC, Sadeghi N, Wright WE, Lum L, Corson TW, Shay JW. KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer. Neoplasia (New York, N.Y.). 16: 247-56, 256.e2. PMID 24784001 DOI: 10.1016/J.Neo.2014.03.008 |
0.611 |
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2014 |
Singel SM, Batten K, Cornelius C, Jia G, Fasciani G, Barron SL, Wright WE, Shay JW. Receptor-interacting protein kinase 2 promotes triple-negative breast cancer cell migration and invasion via activation of nuclear factor-kappaB and c-Jun N-terminal kinase pathways. Breast Cancer Research : Bcr. 16: R28. PMID 24642040 DOI: 10.1186/Bcr3629 |
0.625 |
|
2014 |
Wong MS, Shay JW, Wright WE. Regulation of human telomerase splicing by RNA:RNA pairing. Nature Communications. 5: 3306. PMID 24577044 DOI: 10.1038/Ncomms4306 |
0.597 |
|
2014 |
Uzozie A, Nanni P, Staiano T, Grossmann J, Barkow-Oesterreicher S, Shay JW, Tiwari A, Buffoli F, Laczko E, Marra G. Sorbitol dehydrogenase overexpression and other aspects of dysregulated protein expression in human precancerous colorectal neoplasms: a quantitative proteomics study. Molecular & Cellular Proteomics : McP. 13: 1198-218. PMID 24567419 DOI: 10.1074/Mcp.M113.035105 |
0.382 |
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2014 |
Delgado O, Batten KG, Richardson JA, Xie XJ, Gazdar AF, Kaisani AA, Girard L, Behrens C, Suraokar M, Fasciani G, Wright WE, Story MD, Wistuba II, Minna JD, Shay JW. Radiation-enhanced lung cancer progression in a transgenic mouse model of lung cancer is predictive of outcomes in human lung and breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 1610-22. PMID 24486591 DOI: 10.1158/1078-0432.Ccr-13-2589 |
0.601 |
|
2014 |
Ng WL, Chen G, Wang M, Wang H, Story M, Shay JW, Zhang X, Wang J, Amin AR, Hu B, Cucinotta FA, Wang Y. OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation. Cell Death & Disease. 5: e1024. PMID 24457968 DOI: 10.1038/Cddis.2013.563 |
0.352 |
|
2014 |
Constantinescu S, Hecht K, Sobotzki N, Erzinger MM, Bovet C, Shay JW, Wollscheid B, Sturla SJ, Marra G, Beerenwinkel N. Transcriptomic responses of cancerous and noncancerous human colon cells to sulforaphane and selenium. Chemical Research in Toxicology. 27: 377-86. PMID 24383545 DOI: 10.1021/Tx400427T |
0.421 |
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2014 |
Shay JW. Are short telomeres hallmarks of cancer recurrence? Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 779-81. PMID 24366690 DOI: 10.1158/1078-0432.Ccr-13-3198 |
0.37 |
|
2014 |
Grant JL, Fishbein MC, Hong LS, Krysan K, Minna JD, Shay JW, Walser TC, Dubinett SM. A novel molecular pathway for Snail-dependent, SPARC-mediated invasion in non-small cell lung cancer pathogenesis. Cancer Prevention Research (Philadelphia, Pa.). 7: 150-60. PMID 24253315 DOI: 10.1158/1940-6207.Capr-13-0263 |
0.352 |
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2014 |
Zhou J, Mao B, Zhou Q, Ding D, Wang M, Guo P, Gao Y, Shay JW, Yuan Z, Cong YS. Endoplasmic reticulum stress activates telomerase. Aging Cell. 13: 197-200. PMID 24119029 DOI: 10.1111/Acel.12161 |
0.406 |
|
2014 |
Zhang L, Kim SB, Eskiocak U, Posner B, Das P, Wright WE, De Brabander JK, Shay JW. Therapeutic targeting truncated adenomatous polyposis coli (APC) proteins for the selective killing of colorectal cancer cells Bmc Genomics. 15: O3. DOI: 10.1186/1471-2164-15-S2-O3 |
0.439 |
|
2014 |
Mazumdar T, Agyeman A, Shay JW, Houghton JA. Abstract 467: New molecular model identifying the critical role of the GLI2 oncogene in human colonic epithelial cell (HCEC) transformation Cancer Research. 74: 467-467. DOI: 10.1158/1538-7445.Am2014-467 |
0.416 |
|
2014 |
Schafer AC, Shay JW, Danuser G. Abstract 3147: Low oxygen-driven expression of KrasV12 controls a switch between lung tumor growth and migration Cancer Research. 74: 3147-3147. DOI: 10.1158/1538-7445.Am2014-3147 |
0.429 |
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2014 |
Kim SB, Kaisani A, Shay JW. Risk assessment of space radiation-induced invasive cancer in mouse models of lung and colorectal cancer Journal of Radiation Research. 55. DOI: 10.1093/Jrr/Rrt149 |
0.351 |
|
2013 |
Stadler G, King OD, Robin JD, Shay JW, Wright WE. Facioscapulohumeral muscular dystrophy: Are telomeres the end of the story? Rare Diseases (Austin, Tex.). 1: e26142. PMID 25003004 DOI: 10.4161/rdis.26142 |
0.588 |
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2013 |
Shay JW. Are short telomeres predictive of advanced cancer? Cancer Discovery. 3: 1096-8. PMID 24124228 DOI: 10.1158/2159-8290.Cd-13-0506 |
0.37 |
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2013 |
Kim SB, Ly P, Kaisani A, Zhang L, Wright WE, Shay JW. Mitigation of radiation-induced damage by targeting EGFR in noncancerous human epithelial cells. Radiation Research. 180: 259-67. PMID 23919312 DOI: 10.1667/Rr3371.1 |
0.613 |
|
2013 |
Shay JW. Determining if telomeres matter in colon cancer initiation or progression. Journal of the National Cancer Institute. 105: 1166-8. PMID 23918446 DOI: 10.1093/Jnci/Djt200 |
0.502 |
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2013 |
Ghayee HK, Bhagwandin VJ, Stastny V, Click A, Ding LH, Mizrachi D, Zou YS, Chari R, Lam WL, Bachoo RM, Smith AL, Story MD, Sidhu S, Robinson BG, Nwariaku FE, ... ... Shay JW, et al. Progenitor cell line (hPheo1) derived from a human pheochromocytoma tumor. Plos One. 8: e65624. PMID 23785438 DOI: 10.1371/Journal.Pone.0065624 |
0.439 |
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2013 |
Stadler G, Rahimov F, King OD, Chen JC, Robin JD, Wagner KR, Shay JW, Emerson CP, Wright WE. Telomere position effect regulates DUX4 in human facioscapulohumeral muscular dystrophy. Nature Structural & Molecular Biology. 20: 671-8. PMID 23644600 DOI: 10.1038/Nsmb.2571 |
0.671 |
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2013 |
Wong MS, Chen L, Foster C, Kainthla R, Shay JW, Wright WE. Regulation of telomerase alternative splicing: a target for chemotherapy. Cell Reports. 3: 1028-35. PMID 23562158 DOI: 10.1016/J.Celrep.2013.03.011 |
0.627 |
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2013 |
Mender I, Senturk S, Ozgunes N, Akcali KC, Kletsas D, Gryaznov S, Can A, Shay JW, Dikmen ZG. Imetelstat (a telomerase antagonist) exerts off‑target effects on the cytoskeleton. International Journal of Oncology. 42: 1709-15. PMID 23545855 DOI: 10.3892/Ijo.2013.1865 |
0.5 |
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2013 |
Singel SM, Cornelius C, Batten K, Fasciani G, Wright WE, Lum L, Shay JW. A targeted RNAi screen of the breast cancer genome identifies KIF14 and TLN1 as genes that modulate docetaxel chemosensitivity in triple-negative breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 2061-70. PMID 23479679 DOI: 10.1158/1078-0432.Ccr-13-0082 |
0.61 |
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2013 |
Sato M, Larsen JE, Lee W, Sun H, Shames DS, Dalvi MP, Ramirez RD, Tang H, DiMaio JM, Gao B, Xie Y, Wistuba II, Gazdar AF, Shay JW, Minna JD. Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations. Molecular Cancer Research : McR. 11: 638-50. PMID 23449933 DOI: 10.1158/1541-7786.Mcr-12-0634-T |
0.377 |
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2013 |
Christodoulidou A, Raftopoulou C, Chiourea M, Papaioannou GK, Hoshiyama H, Wright WE, Shay JW, Gagos S. The roles of telomerase in the generation of polyploidy during neoplastic cell growth. Neoplasia (New York, N.Y.). 15: 156-68. PMID 23441130 DOI: 10.1593/Neo.121398 |
0.674 |
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2013 |
Singh M, Hunt CR, Pandita RK, Kumar R, Yang CR, Horikoshi N, Bachoo R, Serag S, Story MD, Shay JW, Powell SN, Gupta A, Jeffery J, Pandita S, Chen BP, et al. Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest. Molecular and Cellular Biology. 33: 1210-22. PMID 23319047 DOI: 10.1128/Mcb.01676-12 |
0.363 |
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2013 |
Ly P, Kim SB, Kaisani AA, Marian G, Wright WE, Shay JW. Aneuploid human colonic epithelial cells are sensitive to AICAR-induced growth inhibition through EGFR degradation. Oncogene. 32: 3139-46. PMID 22890317 DOI: 10.1038/Onc.2012.339 |
0.443 |
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2013 |
Zhang L, Komurov K, Wright WE, Shay JW. Identification of novel driver tumor suppressors through functional interrogation of putative passenger mutations in colorectal cancer. International Journal of Cancer. Journal International Du Cancer. 132: 732-7. PMID 22753261 DOI: 10.1002/Ijc.27705 |
0.595 |
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2013 |
Mender I, Gryaznov S, Dikmen ZG, Wright W, Shay J. Abstract LB-125: A novel telomerase inhibitor. Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-125 |
0.509 |
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2013 |
Farooqi A, Hindle A, Koneru B, Shay J, Reynolds P. Abstract 580: Increased DNA repair capacities and p53/MDM2 pathway aberrations hallmark neuroblastoma cell lines with the alternative lengthening of telomeres (ALT) phenotype. Cancer Research. 73: 580-580. DOI: 10.1158/1538-7445.Am2013-580 |
0.44 |
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2013 |
Khare V, Dammann K, Jambrich M, Roig A, Shay J, Gasche C. Abstract 3712: p21-activated kinase-1 in the prevention of inflammation-driven colon cancer. Cancer Research. 73: 3712-3712. DOI: 10.1158/1538-7445.Am2013-3712 |
0.376 |
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2013 |
Robin JD, Ludlow AT, Stadler G, Magdinier F, Wright WE, Shay JW. P.16.7 Length dependent telomere looping affects long-distant gene expression (5 Mb) in FSHD Neuromuscular Disorders. 23: 824. DOI: 10.1016/J.Nmd.2013.06.644 |
0.427 |
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2012 |
Campregher C, Schmid G, Ferk F, Knasmüller S, Khare V, Kortüm B, Dammann K, Lang M, Scharl T, Spittler A, Roig AI, Shay JW, Gerner C, Gasche C. MSH3-deficiency initiates EMAST without oncogenic transformation of human colon epithelial cells. Plos One. 7: e50541. PMID 23209772 DOI: 10.1371/Journal.Pone.0050541 |
0.422 |
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2012 |
Kim SB, Pandita RK, Eskiocak U, Ly P, Kaisani A, Kumar R, Cornelius C, Wright WE, Pandita TK, Shay JW. Targeting of Nrf2 induces DNA damage signaling and protects colonic epithelial cells from ionizing radiation. Proceedings of the National Academy of Sciences of the United States of America. 109: E2949-55. PMID 23045680 DOI: 10.1073/Pnas.1207718109 |
0.605 |
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2012 |
Ly P, Eskiocak U, Parker CR, Harris KJ, Wright WE, Shay JW. RNAi screening of the human colorectal cancer genome identifies multifunctional tumor suppressors regulating epithelial cell invasion. Cell Research. 22: 1605-8. PMID 23044803 DOI: 10.1038/Cr.2012.140 |
0.624 |
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2012 |
Shay JW, Reddel RR, Wright WE. Cancer. Cancer and telomeres--an ALTernative to telomerase. Science (New York, N.Y.). 336: 1388-90. PMID 22700908 DOI: 10.1126/Science.1222394 |
0.687 |
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2012 |
Chow TT, Zhao Y, Mak SS, Shay JW, Wright WE. Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shortening. Genes & Development. 26: 1167-78. PMID 22661228 DOI: 10.1101/Gad.187211.112 |
0.638 |
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2012 |
Hoshiyama H, Tang J, Batten K, Xiao G, Rouillard JM, Shay JW, Xie Y, Wright WE. Development of methods for quantitative comparison of pooled shRNAs by mass sequencing. Journal of Biomolecular Screening. 17: 258-65. PMID 21956173 DOI: 10.1177/1087057111423101 |
0.549 |
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2012 |
Buseman CM, Wright WE, Shay JW. Is telomerase a viable target in cancer? Mutation Research. 730: 90-7. PMID 21802433 DOI: 10.1016/J.Mrfmmm.2011.07.006 |
0.445 |
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2012 |
Shay J, Wright W, Werbin H. Loss of telomeric DNA during aging may predispose cells to cancer (review). International Journal of Oncology. 3: 559-63. PMID 21573400 DOI: 10.3892/Ijo.3.4.559 |
0.452 |
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2012 |
Holt S, Gollahon L, Willingham T, Barbosa M, Shay J. p53 levels in human mammary epithelial cells expressing wild-type and mutant human papillomavirus type 16 (HPV-16) E6 proteins. International Journal of Oncology. 8: 263-70. PMID 21544354 DOI: 10.3892/Ijo.8.2.263 |
0.651 |
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2012 |
Kobayashi T, Clodi K, Yang Y, Ruan S, Shiku H, Andreeff M, Shay J, Zhang W. Inhibition of telomerase activity correlates with a decrease in the RNA component of telomerase during differentiation. International Journal of Oncology. 11: 13-7. PMID 21528174 DOI: 10.3892/Ijo.11.1.13 |
0.481 |
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2012 |
Shay JW. Abstract PL01-01: The role of telomeres and telomerase in aging and cancer Cancer Prevention Research. 5. DOI: 10.1158/1940-6207.Prev-12-Pl01-01 |
0.49 |
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2012 |
Ly P, Kim SB, Wright WE, Amon A, Shay JW. Abstract 3863: Aneuploid human colonic epithelial cells are sensitive to AICAR-induced growth inhibition through EGFR degradation Cancer Research. 72: 3863-3863. DOI: 10.1158/1538-7445.Am2012-3863 |
0.442 |
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2012 |
Gao B, Huang C, Girard L, Gazdar AF, Shay JW, Minna JD. Abstract 2342: Identification of oncogenes and tumor suppressor genes using immortalized lung bronchial epithelial cells and small airway epithelial cells Cancer Research. 72: 2342-2342. DOI: 10.1158/1538-7445.Am2012-2342 |
0.364 |
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2012 |
Minna JD, Shao C, Das A, Desevo C, Dospoy P, Gao B, Greer R, Hight S, Huffman K, Larsen J, Peyton M, Shields M, Sullivan JP, Sullivan L, Gerber D, ... ... Shay J, et al. Abstract IA3: Lung cancer stem cells, acquired vulnerabilities, and molecular portraits: Translation to the clinic Clinical Cancer Research. 18: IA3-IA3. DOI: 10.1158/1078-0432.12Aacriaslc-Ia3 |
0.369 |
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2012 |
Grant JL, Walser TC, Minna JD, Shay JW, Dubinett SM. Abstract A15: Snail upregulation of SPARC leads to increased invasion in models of both early-and late-stage NSCLC Clinical Cancer Research. 18: A15-A15. DOI: 10.1158/1078-0432.12Aacriaslc-A15 |
0.428 |
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2012 |
Smiraldo PG, Tang J, Shay JW, Wright WE. Cellular Senescence, Telomerase, and Cancer in Human Cells Telomerases: Chemistry, Biology, and Clinical Applications. 243-263. DOI: 10.1002/9781118268667.ch10 |
0.355 |
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2011 |
Kim J, Eskiocak U, Stadler G, Lou Z, Kuro-o M, Shay JW, Wright WE. Short hairpin RNA screen indicates that Klotho beta/FGF19 protein overcomes stasis in human colonic epithelial cells. The Journal of Biological Chemistry. 286: 43294-300. PMID 22020932 DOI: 10.1074/Jbc.M111.267641 |
0.632 |
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2011 |
Shay JW, Wright WE. Role of telomeres and telomerase in cancer. Seminars in Cancer Biology. 21: 349-53. PMID 22015685 DOI: 10.1016/J.Semcancer.2011.10.001 |
0.715 |
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2011 |
Stadler G, Chen JC, Wagner K, Robin JD, Shay JW, Emerson CP, Wright WE. Establishment of clonal myogenic cell lines from severely affected dystrophic muscles - CDK4 maintains the myogenic population. Skeletal Muscle. 1: 12. PMID 21798090 DOI: 10.1186/2044-5040-1-12 |
0.624 |
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2011 |
Delgado O, Kaisani AA, Spinola M, Xie XJ, Batten KG, Minna JD, Wright WE, Shay JW. Multipotent capacity of immortalized human bronchial epithelial cells. Plos One. 6: e22023. PMID 21760947 DOI: 10.1371/Journal.Pone.0022023 |
0.632 |
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2011 |
Wang H, Venkatesh M, Li H, Goetz R, Mukherjee S, Biswas A, Zhu L, Kaubisch A, Wang L, Pullman J, Whitney K, Kuro-o M, Roig AI, Shay JW, Mohammadi M, et al. Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice. The Journal of Clinical Investigation. 121: 3220-32. PMID 21747170 DOI: 10.1172/Jci41514 |
0.407 |
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2011 |
Zhao Y, Abreu E, Kim J, Stadler G, Eskiocak U, Terns MP, Terns RM, Shay JW, Wright WE. Processive and distributive extension of human telomeres by telomerase under homeostatic and nonequilibrium conditions. Molecular Cell. 42: 297-307. PMID 21549308 DOI: 10.1016/J.Molcel.2011.03.020 |
0.65 |
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2011 |
Eskiocak U, Kim SB, Ly P, Roig AI, Biglione S, Komurov K, Cornelius C, Wright WE, White MA, Shay JW. Functional parsing of driver mutations in the colorectal cancer genome reveals numerous suppressors of anchorage-independent growth. Cancer Research. 71: 4359-65. PMID 21527559 DOI: 10.1158/0008-5472.Can-11-0794 |
0.606 |
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2011 |
Gomes NM, Ryder OA, Houck ML, Charter SJ, Walker W, Forsyth NR, Austad SN, Venditti C, Pagel M, Shay JW, Wright WE. Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination. Aging Cell. 10: 761-8. PMID 21518243 DOI: 10.1111/J.1474-9726.2011.00718.X |
0.665 |
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2011 |
Ly P, Eskiocak U, Kim SB, Roig AI, Hight SK, Lulla DR, Zou YS, Batten K, Wright WE, Shay JW. Characterization of aneuploid populations with trisomy 7 and 20 derived from diploid human colonic epithelial cells. Neoplasia (New York, N.Y.). 13: 348-57. PMID 21472139 DOI: 10.1593/Neo.101580 |
0.671 |
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2011 |
Zhao Y, Shay JW, Wright WE. Telomere terminal G/C strand synthesis: measuring telomerase action and C-rich fill-in. Methods in Molecular Biology (Clifton, N.J.). 735: 63-75. PMID 21461812 DOI: 10.1007/978-1-61779-092-8_7 |
0.686 |
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2011 |
Zhao Y, Shay JW, Wright WE. Telomere G-overhang length measurement method 1: the DSN method. Methods in Molecular Biology (Clifton, N.J.). 735: 47-54. PMID 21461810 DOI: 10.1007/978-1-61779-092-8_5 |
0.606 |
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2011 |
Asaithamby A, Hu B, Delgado O, Ding LH, Story MD, Minna JD, Shay JW, Chen DJ. Irreparable complex DNA double-strand breaks induce chromosome breakage in organotypic three-dimensional human lung epithelial cell culture. Nucleic Acids Research. 39: 5474-88. PMID 21421565 DOI: 10.1093/Nar/Gkr149 |
0.374 |
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2011 |
Ouellette MM, Wright WE, Shay JW. Targeting telomerase-expressing cancer cells. Journal of Cellular and Molecular Medicine. 15: 1433-42. PMID 21332640 DOI: 10.1111/J.1582-4934.2011.01279.X |
0.631 |
|
2011 |
Marian CO, Yang L, Zou YS, Gore C, Pong RC, Shay JW, Kabbani W, Hsieh JT, Raj GV. Evidence of epithelial to mesenchymal transition associated with increased tumorigenic potential in an immortalized normal prostate epithelial cell line. The Prostate. 71: 626-36. PMID 20945502 DOI: 10.1002/Pros.21278 |
0.351 |
|
2011 |
Frink RE, Girard L, Wright WE, Shay JW, Minna JD. Abstract 4513: Predicting response of non-small cell lung cancer to the telomerase inhibitor imetelstat Cancer Research. 71: 4513-4513. DOI: 10.1158/1538-7445.Am2011-4513 |
0.443 |
|
2011 |
Konstantinidou G, Torti F, Batten K, Minna JD, Shay JW, Scaglioni PP. Abstract 3850: CDKN2a deficiency exposes a requirement for RhoA in maintenance of non-small cell lung cancer Cancer Research. 71: 3850-3850. DOI: 10.1158/1538-7445.Am2011-3850 |
0.375 |
|
2011 |
Larsen JE, Sato M, Sullivan JP, Girard L, Shay JW, Minna JD. Abstract 3419: Defining the role of ZEB1 in the molecular pathogenesis of lung cancer Cancer Research. 71: 3419-3419. DOI: 10.1158/1538-7445.Am2011-3419 |
0.423 |
|
2011 |
Eskiocak U, Kim SB, Ly P, Roig AI, Biglione S, Komurov K, Cornelius C, Wright WE, White MA, Shay JW. Abstract 2207: Functional interrogation of the colorectal cancer genome identifies numerous suppressors of anchorage-independent growth Cancer Research. 71: 2207-2207. DOI: 10.1158/1538-7445.Am2011-2207 |
0.369 |
|
2011 |
Rajagopalan KN, Marian CO, Shay JW, DeBerardinis RJ. Abstract 1248: Enhanced glutamine metabolism contributes to docetaxel resistance in DU145 prostate cancer cells Cancer Research. 71: 1248-1248. DOI: 10.1158/1538-7445.Am2011-1248 |
0.351 |
|
2011 |
Bassett E, Frink R, Augustyn A, Girard L, Go N, Schiller J, Wright W, Shay J, Minn J. PP 7 The non-small cell lung cancers exhibit distinct response phenotypes to telomerase inhibitor imetelstat European Journal of Cancer. 47: S11. DOI: 10.1016/S0959-8049(11)72630-2 |
0.363 |
|
2011 |
Boyd DT, Miller MR, Wright WE, Horton JD, Shay JW, Roig AI. Human Liver Progenitor Cell Expansion With Preservation of Differentiation Capability Into Functional Hepatocytes Gastroenterology. 140. DOI: 10.1016/S0016-5085(11)64043-2 |
0.323 |
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2010 |
Sullivan JP, Spinola M, Dodge M, Raso MG, Behrens C, Gao B, Schuster K, Shao C, Larsen JE, Sullivan LA, Honorio S, Xie Y, Scaglioni PP, DiMaio JM, Gazdar AF, ... Shay JW, et al. Aldehyde dehydrogenase activity selects for lung adenocarcinoma stem cells dependent on notch signaling. Cancer Research. 70: 9937-48. PMID 21118965 DOI: 10.1158/0008-5472.Can-10-0881 |
0.414 |
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2010 |
Joseph I, Tressler R, Bassett E, Harley C, Buseman CM, Pattamatta P, Wright WE, Shay JW, Go NF. The telomerase inhibitor imetelstat depletes cancer stem cells in breast and pancreatic cancer cell lines. Cancer Research. 70: 9494-504. PMID 21062983 DOI: 10.1158/0008-5472.Can-10-0233 |
0.674 |
|
2010 |
Shultz JC, Goehe RW, Wijesinghe DS, Murudkar C, Hawkins AJ, Shay JW, Minna JD, Chalfant CE. Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a. Cancer Research. 70: 9185-96. PMID 21045158 DOI: 10.1158/0008-5472.Can-10-1545 |
0.331 |
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2010 |
Goehe RW, Shultz JC, Murudkar C, Usanovic S, Lamour NF, Massey DH, Zhang L, Camidge DR, Shay JW, Minna JD, Chalfant CE. hnRNP L regulates the tumorigenic capacity of lung cancer xenografts in mice via caspase-9 pre-mRNA processing. The Journal of Clinical Investigation. 120: 3923-39. PMID 20972334 DOI: 10.1172/Jci43552 |
0.328 |
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2010 |
Eskiocak U, Kim SB, Roig AI, Kitten E, Batten K, Cornelius C, Zou YS, Wright WE, Shay JW. CDDO-Me protects against space radiation-induced transformation of human colon epithelial cells. Radiation Research. 174: 27-36. PMID 20681796 DOI: 10.1667/Rr2155.1 |
0.619 |
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2010 |
Gomes NM, Shay JW, Wright WE. Telomere biology in Metazoa. Febs Letters. 584: 3741-51. PMID 20655915 DOI: 10.1016/J.Febslet.2010.07.031 |
0.623 |
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2010 |
Shay JW, Wright WE. Telomeres and telomerase in normal and cancer stem cells. Febs Letters. 584: 3819-25. PMID 20493857 DOI: 10.1016/J.Febslet.2010.05.026 |
0.657 |
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2010 |
Chakravarti N, Kadara H, Yoon DJ, Shay JW, Myers JN, Lotan D, Sonenberg N, Lotan R. Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells. Cancer Prevention Research (Philadelphia, Pa.). 3: 331-8. PMID 20145189 DOI: 10.1158/1940-6207.Capr-09-0076 |
0.432 |
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2010 |
Sullivan JP, Minna JD, Shay JW. Evidence for self-renewing lung cancer stem cells and their implications in tumor initiation, progression, and targeted therapy. Cancer Metastasis Reviews. 29: 61-72. PMID 20094757 DOI: 10.1007/S10555-010-9216-5 |
0.388 |
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2010 |
Marian CO, Cho SK, McEllin BM, Maher EA, Hatanpaa KJ, Madden CJ, Mickey BE, Wright WE, Shay JW, Bachoo RM. The telomerase antagonist, imetelstat, efficiently targets glioblastoma tumor-initiating cells leading to decreased proliferation and tumor growth. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 154-63. PMID 20048334 DOI: 10.1158/1078-0432.Ccr-09-2850 |
0.63 |
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2010 |
Roig AI, Eskiocak U, Hight SK, Kim SB, Delgado O, Souza RF, Spechler SJ, Wright WE, Shay JW. Immortalized epithelial cells derived from human colon biopsies express stem cell markers and differentiate in vitro. Gastroenterology. 138: 1012-21.e1-5. PMID 19962984 DOI: 10.1053/J.Gastro.2009.11.052 |
0.655 |
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2010 |
Atzmon G, Cho M, Cawthon RM, Budagov T, Katz M, Yang X, Siegel G, Bergman A, Huffman DM, Schechter CB, Wright WE, Shay JW, Barzilai N, Govindaraju DR, Suh Y. Evolution in health and medicine Sackler colloquium: Genetic variation in human telomerase is associated with telomere length in Ashkenazi centenarians. Proceedings of the National Academy of Sciences of the United States of America. 107: 1710-7. PMID 19915151 DOI: 10.1073/Pnas.0906191106 |
0.615 |
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2010 |
Marian CO, Wright WE, Shay JW. The effects of telomerase inhibition on prostate tumor-initiating cells. International Journal of Cancer. Journal International Du Cancer. 127: 321-31. PMID 19908230 DOI: 10.1002/Ijc.25043 |
0.602 |
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2010 |
Hazra S, Gardner BK, Krysan K, Walser TC, Larsen JE, Pertsemlidis A, Shay JW, Minna JD, Spira A, Dubinett SM. Abstract A31: The role of microRNA 125a‐3P in the pathogenesis of lung cancer Cancer Prevention Research. 3. DOI: 10.1158/1940-6207.Prev-09-A31 |
0.39 |
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2010 |
Frink RE, Peyton M, Sullivan JP, Wright WE, Schiller J, Shay JW, Minna JD. Abstract 3577: Sensitivity and resistance of non-small cell lung cancer to the telomerase inhibitor imetelstat Cancer Research. 70: 3577-3577. DOI: 10.1158/1538-7445.Am10-3577 |
0.452 |
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2010 |
Gao B, Huang C, Sullivan J, Raso G, Wistuba I, Shay J, Minna J. Abstract 3230: Immortalization of human small airway epithelial cells as a model for studying lung tumor transformation Cancer Research. 70: 3230-3230. DOI: 10.1158/1538-7445.Am10-3230 |
0.418 |
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2010 |
Larsen JE, Sato M, Sullivan JP, Girard L, Xie Y, Shay JW, Minna JD. Abstract 2362: Defining the role of ZEB1 in the molecular pathogenesis of lung cancer Cancer Research. 70: 2362-2362. DOI: 10.1158/1538-7445.Am10-2362 |
0.432 |
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2010 |
Roig AI, Shay JW. Immortalization of adult human colonic epithelial cells extracted from normal tissues obtained via colonoscopy Nature Protocols. DOI: 10.1038/Nprot.2010.29 |
0.34 |
|
2009 |
Lou Z, Wei J, Riethman H, Baur JA, Voglauer R, Shay JW, Wright WE. Telomere length regulates ISG15 expression in human cells. Aging. 1: 608-21. PMID 20157543 |
0.649 |
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2009 |
Vaughan MB, Ramirez RD, Andrews CM, Wright WE, Shay JW. H-ras expression in immortalized keratinocytes produces an invasive epithelium in cultured skin equivalents. Plos One. 4: e7908. PMID 19936293 DOI: 10.1371/Journal.Pone.0007908 |
0.777 |
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2009 |
Yoon H, Kim DJ, Ahn EH, Gellert GC, Shay JW, Ahn CH, Lee YB. Antitumor activity of a novel antisense oligonucleotide against Akt1. Journal of Cellular Biochemistry. 108: 832-8. PMID 19693774 DOI: 10.1002/Jcb.22311 |
0.4 |
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2009 |
Zhao Y, Sfeir AJ, Zou Y, Buseman CM, Chow TT, Shay JW, Wright WE. Telomere extension occurs at most chromosome ends and is uncoupled from fill-in in human cancer cells. Cell. 138: 463-75. PMID 19665970 DOI: 10.1016/J.Cell.2009.05.026 |
0.673 |
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2009 |
Walker RF, Pakula LC, Sutcliffe MJ, Kruk PA, Graakjaer J, Shay JW. A case study of "disorganized development" and its possible relevance to genetic determinants of aging. Mechanisms of Ageing and Development. 130: 350-6. PMID 19428454 DOI: 10.1016/J.Mad.2009.02.003 |
0.347 |
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2009 |
Matsuo T, Shay JW, Wright WE, Hiyama E, Shimose S, Kubo T, Sugita T, Yasunaga Y, Ochi M. Telomere-maintenance mechanisms in soft-tissue malignant fibrous histiocytomas. The Journal of Bone and Joint Surgery. American Volume. 91: 928-37. PMID 19339578 DOI: 10.2106/Jbjs.G.01390 |
0.6 |
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2009 |
Marian CO, Shay JW. Prostate tumor-initiating cells: a new target for telomerase inhibition therapy? Biochimica Et Biophysica Acta. 1792: 289-96. PMID 19264126 DOI: 10.1016/J.Bbadis.2009.02.012 |
0.386 |
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2009 |
Bhagwandin VJ, Shay JW. Pancreatic cancer stem cells: fact or fiction? Biochimica Et Biophysica Acta. 1792: 248-59. PMID 19233264 DOI: 10.1016/J.Bbadis.2009.02.007 |
0.379 |
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2009 |
Zou Y, Misri S, Shay JW, Pandita TK, Wright WE. Altered states of telomere deprotection and the two-stage mechanism of replicative aging. Molecular and Cellular Biology. 29: 2390-7. PMID 19223460 DOI: 10.1128/Mcb.01569-08 |
0.634 |
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2009 |
Roig AI, Hight SK, Shay JW. Two- and three-dimensional models for risk assessment of radiation-enhanced colorectal tumorigenesis. Radiation Research. 171: 33-40. PMID 19138051 DOI: 10.1667/Rr1415.1 |
0.373 |
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2009 |
Shay J, Keith WN. Cellular immortality and cancer: From telomerase to cancer stem cells Biochimica Et Biophysica Acta. 1792: 227-228. DOI: 10.1016/J.Bbadis.2009.03.006 |
0.387 |
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2009 |
Roig AI, Wright WE, Shay JW. Is telomerase a novel target for metastatic colon cancer? Current Colorectal Cancer Reports. 5: 203-208. DOI: 10.1007/S11888-009-0028-3 |
0.431 |
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2008 |
Zhu CH, Kim J, Shay JW, Wright WE. SGNP: an essential Stress Granule/Nucleolar Protein potentially involved in 5.8s rRNA processing/transport. Plos One. 3: e3716. PMID 19005571 DOI: 10.1371/Journal.Pone.0003716 |
0.562 |
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2008 |
Gagos S, Chiourea M, Christodoulidou A, Apostolou E, Raftopoulou C, Deustch S, Jefford CE, Irminger-Finger I, Shay JW, Antonarakis SE. Pericentromeric instability and spontaneous emergence of human neoacrocentric and minute chromosomes in the alternative pathway of telomere lengthening. Cancer Research. 68: 8146-55. PMID 18829574 DOI: 10.1158/0008-5472.Can-08-0945 |
0.378 |
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2008 |
Cong Y, Shay JW. Actions of human telomerase beyond telomeres. Cell Research. 18: 725-32. PMID 18574498 DOI: 10.1038/Cr.2008.74 |
0.484 |
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2008 |
Agarwal M, Pandita S, Hunt CR, Gupta A, Yue X, Khan S, Pandita RK, Pratt D, Shay JW, Taylor JS, Pandita TK. Inhibition of telomerase activity enhances hyperthermia-mediated radiosensitization. Cancer Research. 68: 3370-8. PMID 18451164 DOI: 10.1158/0008-5472.Can-07-5831 |
0.413 |
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2008 |
Dikmen ZG, Gellert GC, Dogan P, Yoon H, Lee YB, Ahn CH, Shay JW. In vivo and in vitro effects of a HIF-1alpha inhibitor, RX-0047. Journal of Cellular Biochemistry. 104: 985-94. PMID 18275063 DOI: 10.1002/Jcb.21681 |
0.401 |
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2008 |
Shay JW, Keith WN. Targeting telomerase for cancer therapeutics. British Journal of Cancer. 98: 677-83. PMID 18231105 DOI: 10.1038/Sj.Bjc.6604209 |
0.404 |
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2008 |
Sarosi G, Brown G, Jaiswal K, Feagins LA, Lee E, Crook TW, Souza RF, Zou YS, Shay JW, Spechler SJ. Bone marrow progenitor cells contribute to esophageal regeneration and metaplasia in a rat model of Barrett's esophagus Diseases of the Esophagus. 21: 43-50. PMID 18197938 DOI: 10.1111/J.1442-2050.2007.00744.X |
0.324 |
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2008 |
Zhao Y, Hoshiyama H, Shay JW, Wright WE. Quantitative telomeric overhang determination using a double-strand specific nuclease. Nucleic Acids Research. 36: e14. PMID 18073199 DOI: 10.1093/Nar/Gkm1063 |
0.601 |
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2008 |
Dikmen ZG, Wright WE, Shay JW, Gryaznov SM. Telomerase targeted oligonucleotide thio-phosphoramidates in T24-luc bladder cancer cells. Journal of Cellular Biochemistry. 104: 444-52. PMID 18044713 DOI: 10.1002/Jcb.21635 |
0.651 |
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2008 |
Pearce VP, Sherrell J, Lou Z, Kopelovich L, Wright WE, Shay JW. Immortalization of epithelial progenitor cells mediated by resveratrol. Oncogene. 27: 2365-74. PMID 17968319 DOI: 10.1038/Sj.Onc.1210886 |
0.464 |
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2008 |
Shay J. Abstract ED04-01: Aging and cancer: are telomeres and telomerase the connection? Cancer Prevention Research. 1. DOI: 10.1158/1940-6207.Prev-08-Ed04-01 |
0.533 |
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2008 |
Shay JW, Wright WE. 20 Telomeres and Telomerase in Aging and Cancer Cold Spring Harbor Monograph Archive. 51: 575-597. DOI: 10.1101/087969824.51.575 |
0.431 |
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2008 |
Roig AI, Hight SK, Shay JW. W1980 Immortalization and Characterization of a Human Colonic Epithelial Cell Line Gastroenterology. 134. DOI: 10.1016/S0016-5085(08)63487-3 |
0.383 |
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2007 |
Natarajan S, Chow TT, Shay JW, Wright WE. Replica plating of mammalian cells using low melt agarose. Cytotechnology. 54: 145-7. PMID 19003006 DOI: 10.1007/S10616-007-9071-6 |
0.6 |
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2007 |
Gryaznov SM, Jackson S, Dikmen G, Harley C, Herbert BS, Wright WE, Shay JW. Oligonucleotide conjugate GRN163L targeting human telomerase as potential anticancer and antimetastatic agent. Nucleosides, Nucleotides & Nucleic Acids. 26: 1577-9. PMID 18066830 DOI: 10.1080/15257770701547271 |
0.637 |
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2007 |
Garcia CK, Wright WE, Shay JW. Human diseases of telomerase dysfunction: insights into tissue aging. Nucleic Acids Research. 35: 7406-16. PMID 17913752 DOI: 10.1093/Nar/Gkm644 |
0.602 |
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2007 |
Keith WN, Thomson CM, Howcroft J, Maitland NJ, Shay JW. Seeding drug discovery: integrating telomerase cancer biology and cellular senescence to uncover new therapeutic opportunities in targeting cancer stem cells Drug Discovery Today. 12: 611-621. PMID 17706542 DOI: 10.1016/J.Drudis.2007.06.009 |
0.387 |
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2007 |
Shay JW, Wright WE. Tissue culture as a hostile environment: identifying conditions for breast cancer progression studies. Cancer Cell. 12: 100-1. PMID 17692800 DOI: 10.1016/J.Ccr.2007.07.012 |
0.629 |
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2007 |
Liu M, Yang SC, Sharma S, Luo J, Cui X, Peebles KA, Huang M, Sato M, Ramirez RD, Shay JW, Minna JD, Dubinett SM. EGFR signaling is required for TGF-β1-mediated COX-2 induction in human bronchial epithelial cells American Journal of Respiratory Cell and Molecular Biology. 37: 578-588. PMID 17600311 DOI: 10.1165/Rcmb.2007-0100Oc |
0.301 |
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2007 |
Zhu CH, Mouly V, Cooper RN, Mamchaoui K, Bigot A, Shay JW, Di Santo JP, Butler-Browne GS, Wright WE. Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies. Aging Cell. 6: 515-23. PMID 17559502 DOI: 10.1111/J.1474-9726.2007.00306.X |
0.652 |
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2007 |
Lam DC, Girard L, Ramirez R, Chau WS, Suen WS, Sheridan S, Tin VP, Chung LP, Wong MP, Shay JW, Gazdar AF, Lam WK, Minna JD. Expression of nicotinic acetylcholine receptor subunit genes in non-small-cell lung cancer reveals differences between smokers and nonsmokers. Cancer Research. 67: 4638-47. PMID 17510389 DOI: 10.1158/0008-5472.Can-06-4628 |
0.303 |
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2007 |
Gardner JP, Kimura M, Chai W, Durrani JF, Tchakmakjian L, Cao X, Lu X, Li G, Peppas AP, Skurnick J, Wright WE, Shay JW, Aviv A. Telomere dynamics in macaques and humans. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 62: 367-74. PMID 17452729 DOI: 10.1093/Gerona/62.4.367 |
0.631 |
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2007 |
Souza RF, Lunsford T, Ramirez RD, Zhang X, Lee EL, Shen Y, Owen C, Shay JW, Morales C, Spechler SJ. GERD is associated with shortened telomeres in the squamous epithelium of the distal esophagus. American Journal of Physiology. Gastrointestinal and Liver Physiology. 293: G19-24. PMID 17395902 DOI: 10.1152/Ajpgi.00055.2007 |
0.386 |
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2007 |
Jackson SR, Zhu CH, Paulson V, Watkins L, Dikmen ZG, Gryaznov SM, Wright WE, Shay JW. Antiadhesive effects of GRN163L--an oligonucleotide N3'->P5' thio-phosphoramidate targeting telomerase. Cancer Research. 67: 1121-9. PMID 17283146 DOI: 10.1158/0008-5472.Can-06-2306 |
0.659 |
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2007 |
Shay JW, Wright WE. Hallmarks of telomeres in ageing research. The Journal of Pathology. 211: 114-23. PMID 17200948 DOI: 10.1002/Path.2090 |
0.537 |
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2007 |
Shay JW, Sato M, Lee W, Girard L, Xie X, Xie Y, Sullivan J, Spinola M, Minna JD. M10-04: Telomerase immortalized human bronchial epithelial cells (HBECs) have stem cell characteristics Journal of Thoracic Oncology. 2. DOI: 10.1097/01.Jto.0000282960.07437.60 |
0.395 |
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2006 |
Wright WE, Shay JW. Inexpensive low-oxygen incubators. Nature Protocols. 1: 2088-90. PMID 17487199 DOI: 10.1038/Nprot.2006.374 |
0.558 |
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2006 |
Herbert BS, Hochreiter AE, Wright WE, Shay JW. Nonradioactive detection of telomerase activity using the telomeric repeat amplification protocol. Nature Protocols. 1: 1583-90. PMID 17406450 DOI: 10.1038/Nprot.2006.239 |
0.586 |
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2006 |
Shames DS, Girard L, Gao B, Sato M, Lewis CM, Shivapurkar N, Jiang A, Perou CM, Kim YH, Pollack JR, Fong KM, Lam CL, Wong M, Shyr Y, Nanda R, ... ... Shay JW, et al. A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies. Plos Medicine. 3: e486. PMID 17194187 DOI: 10.1371/Journal.Pmed.0030486 |
0.349 |
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2006 |
Das AK, Sato M, Story MD, Peyton M, Graves R, Redpath S, Girard L, Gazdar AF, Shay JW, Minna JD, Nirodi CS. Non-small-cell lung cancers with kinase domain mutations in the epidermal growth factor receptor are sensitive to ionizing radiation. Cancer Research. 66: 9601-8. PMID 17018617 DOI: 10.1158/0008-5472.Can-06-2627 |
0.301 |
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2006 |
Shay JW, Wright WE. Telomerase therapeutics for cancer: challenges and new directions. Nature Reviews. Drug Discovery. 5: 577-84. PMID 16773071 DOI: 10.1038/Nrd2081 |
0.653 |
|
2006 |
Vaughan MB, Ramirez RD, Wright WE, Minna JD, Shay JW. A three-dimensional model of differentiation of immortalized human bronchial epithelial cells. Differentiation; Research in Biological Diversity. 74: 141-8. PMID 16683984 DOI: 10.1111/J.1432-0436.2006.00069.X |
0.824 |
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2006 |
Finkel T, Vijg J, Shay JW. Time, tumours and telomeres: Meeting on cancer and aging Embo Reports. 7: 479-483. PMID 16641934 DOI: 10.1038/Sj.Embor.7400680 |
0.454 |
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2006 |
Liu Z, Widlak P, Zou Y, Xiao F, Oh M, Li S, Chang MY, Shay JW, Garrard WT. A recombination silencer that specifies heterochromatin positioning and ikaros association in the immunoglobulin kappa locus. Immunity. 24: 405-15. PMID 16618599 DOI: 10.1016/J.Immuni.2006.02.001 |
0.31 |
|
2006 |
Lewis CM, Herbert BS, Bu D, Halloway S, Beck A, Shadeo A, Zhang C, Ashfaq R, Shay JW, Euhus DM. Telomerase immortalization of human mammary epithelial cells derived from a BRCA2 mutation carrier Breast Cancer Research and Treatment. 99: 103-115. PMID 16541310 DOI: 10.1007/S10549-006-9189-9 |
0.452 |
|
2006 |
Canales BK, Li Y, Thompson MG, Gleason JM, Chen Z, Malaeb B, Corey DR, Herbert BS, Shay JW, Koeneman KS. Small molecule, oligonucleotide-based telomerase template inhibition in combination with cytolytic therapy in an in vitro androgen-independent prostate cancer model. Urologic Oncology. 24: 141-51. PMID 16520278 DOI: 10.1016/J.Urolonc.2005.11.003 |
0.376 |
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2006 |
Sato M, Vaughan MB, Girard L, Peyton M, Lee W, Shames DS, Ramirez RD, Sunaga N, Gazdar AF, Shay JW, Minna JD. Multiple oncogenic changes (K-RASV12, p53 knockdown, mutant EGFRs, p16 bypass, telomerase) are not sufficient to confer a full malignant phenotype on human bronchial epithelial cells Cancer Research. 66: 2116-2128. PMID 16489012 DOI: 10.1158/0008-5472.Can-05-2521 |
0.758 |
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2006 |
Chai W, Du Q, Shay JW, Wright WE. Human telomeres have different overhang sizes at leading versus lagging strands. Molecular Cell. 21: 427-35. PMID 16455497 DOI: 10.1016/J.Molcel.2005.12.004 |
0.678 |
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2006 |
Moshnikova A, Frye J, Shay JW, Minna JD, Khokhlatchev AV. The growth and tumor suppressor NORE1A is a cytoskeletal protein that suppresses growth by inhibition of the ERK pathway Journal of Biological Chemistry. 281: 8143-8152. PMID 16421102 DOI: 10.1074/Jbc.M511837200 |
0.329 |
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2006 |
Chai W, Sfeir AJ, Hoshiyama H, Shay JW, Wright WE. The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres. Embo Reports. 7: 225-30. PMID 16374507 DOI: 10.1038/Sj.Embor.7400600 |
0.659 |
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2006 |
Gellert GC, Dikmen ZG, Wright WE, Gryaznov S, Shay JW. Effects of a novel telomerase inhibitor, GRN163L, in human breast cancer. Breast Cancer Research and Treatment. 96: 73-81. PMID 16319992 DOI: 10.1007/S10549-005-9043-5 |
0.679 |
|
2006 |
Shay JW, Wright WE. 4 Telomerase and Human Cancer Cold Spring Harbor Monograph Archive. 45: 81-108. DOI: 10.1101/087969810.45.81 |
0.529 |
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2005 |
Shay JW, Wright WE. Use of telomerase to create bioengineered tissues. Annals of the New York Academy of Sciences. 1057: 479-91. PMID 16399914 DOI: 10.1196/Annals.1356.037 |
0.69 |
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2005 |
Alonso MM, Fueyo J, Shay JW, Aldape KD, Jiang H, Lee OH, Johnson DG, Xu J, Kondo Y, Kanzawa T, Kyo S, Bekele BN, Zhou X, Nigro J, McDonald JM, et al. Expression of transcription factor E2F1 and telomerase in glioblastomas: mechanistic linkage and prognostic significance. Journal of the National Cancer Institute. 97: 1589-600. PMID 16264179 DOI: 10.1093/Jnci/Dji340 |
0.386 |
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2005 |
Sfeir AJ, Shay JW, Wright WE. Fine-tuning the chromosome ends: the last base of human telomeres. Cell Cycle (Georgetown, Tex.). 4: 1467-70. PMID 16258279 DOI: 10.4161/Cc.4.11.2161 |
0.645 |
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2005 |
Sashida G, Ohyashiki JH, Kubota N, Shoji N, Ishii Y, Tauchi T, Kimura Y, Shay JW, Ohyashiki K. Marked telomere fluctuation of leukocytes during graft-versus-host disease in allogeneic stem cell transplantation. International Journal of Molecular Medicine. 16: 883-8. PMID 16211259 DOI: 10.3892/Ijmm.16.5.883 |
0.341 |
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2005 |
Dikmen ZG, Gellert GC, Jackson S, Gryaznov S, Tressler R, Dogan P, Wright WE, Shay JW. In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor. Cancer Research. 65: 7866-73. PMID 16140956 DOI: 10.1158/0008-5472.Can-05-1215 |
0.65 |
|
2005 |
Takakura M, Kyo S, Inoue M, Wright WE, Shay JW. Function of AP-1 in transcription of the telomerase reverse transcriptase gene (TERT) in human and mouse cells. Molecular and Cellular Biology. 25: 8037-43. PMID 16135795 DOI: 10.1128/Mcb.25.18.8037-8043.2005 |
0.617 |
|
2005 |
Wright WE, Shay JW. Telomere biology in aging and cancer. Journal of the American Geriatrics Society. 53: S292-4. PMID 16131355 DOI: 10.1111/J.1532-5415.2005.53492.X |
0.679 |
|
2005 |
Michaloglou C, Vredeveld LCW, Soengas MS, Denoyelle C, Kuilman T, Van Der Horst CMAM, Majoor DM, Shay JW, Mooi WJ, Peeper DS. BRAFE600-associated senescence-like cell cycle arrest of human naevi Nature. 436: 720-724. PMID 16079850 DOI: 10.1038/Nature03890 |
0.425 |
|
2005 |
Hockemeyer D, Sfeir AJ, Shay JW, Wright WE, de Lange T. POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. The Embo Journal. 24: 2667-78. PMID 15973431 DOI: 10.1038/Sj.Emboj.7600733 |
0.655 |
|
2005 |
Aviv A, Shay J, Christensen K, Wright W. The longevity gender gap: are telomeres the explanation? Science of Aging Knowledge Environment : Sage Ke. 2005: pe16. PMID 15944464 DOI: 10.1126/Sageke.2005.23.Pe16 |
0.577 |
|
2005 |
Herbert BS, Gellert GC, Hochreiter A, Pongracz K, Wright WE, Zielinska D, Chin AC, Harley CB, Shay JW, Gryaznov SM. Lipid modification of GRN163, an N3'-->P5' thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition. Oncogene. 24: 5262-8. PMID 15940257 DOI: 10.1038/Sj.Onc.1208760 |
0.676 |
|
2005 |
Forsyth NR, Elder FF, Shay JW, Wright WE. Lagomorphs (rabbits, pikas and hares) do not use telomere-directed replicative aging in vitro. Mechanisms of Ageing and Development. 126: 685-91. PMID 15888323 DOI: 10.1016/J.Mad.2005.01.003 |
0.636 |
|
2005 |
Shay JW. Meeting report: The role of telomeres and telomerase in cancer Cancer Research. 65: 3513-3517. PMID 15867339 DOI: 10.1158/0008-5472.Can-05-0728 |
0.361 |
|
2005 |
Sfeir AJ, Chai W, Shay JW, Wright WE. Telomere-end processing the terminal nucleotides of human chromosomes. Molecular Cell. 18: 131-8. PMID 15808515 DOI: 10.1016/J.Molcel.2005.02.035 |
0.621 |
|
2005 |
Chai W, Shay JW, Wright WE. Human telomeres maintain their overhang length at senescence. Molecular and Cellular Biology. 25: 2158-68. PMID 15743814 DOI: 10.1128/Mcb.25.6.2158-2168.2005 |
0.658 |
|
2005 |
Hofer AC, Tran RT, Aziz OZ, Wright W, Novelli G, Shay J, Lewis M. Shared phenotypes among segmental progeroid syndromes suggest underlying pathways of aging. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 60: 10-20. PMID 15741277 DOI: 10.1093/Gerona/60.1.10 |
0.577 |
|
2005 |
Wright WE, Shay JW. Telomere-binding factors and general DNA repair. Nature Genetics. 37: 116-8. PMID 15678140 DOI: 10.1038/Ng0205-116 |
0.59 |
|
2005 |
Robertson DM, Li L, Fisher S, Pearce VP, Shay JW, Wright WE, Cavanagh HD, Jester JV. Characterization of growth and differentiation in a telomerase-immortalized human corneal epithelial cell line. Investigative Ophthalmology & Visual Science. 46: 470-8. PMID 15671271 DOI: 10.1167/Iovs.04-0528 |
0.661 |
|
2005 |
Shay JW, Wright WE. Mechanism-based combination telomerase inhibition therapy. Cancer Cell. 7: 1-2. PMID 15652743 DOI: 10.1016/J.Ccr.2004.12.012 |
0.643 |
|
2005 |
Shay JW, Wright WE. Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis. 26: 867-74. PMID 15471900 DOI: 10.1093/Carcin/Bgh296 |
0.694 |
|
2005 |
Gellert GC, Jackson SR, Dikmen ZG, Wright WE, Shay JW. Telomerase as a therapeutic target in cancer Drug Discovery Today: Disease Mechanisms. 2: 159-164. DOI: 10.1016/J.Ddmec.2005.05.009 |
0.412 |
|
2004 |
Ramirez RD, Sheridan S, Girard L, Sato M, Kim Y, Pollack J, Peyton M, Zou Y, Kurie JM, Dimaio JM, Milchgrub S, Smith AL, Souza RF, Gilbey L, Zhang X, ... ... Shay JW, et al. Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins. Cancer Research. 64: 9027-34. PMID 15604268 DOI: 10.1158/0008-5472.Can-04-3703 |
0.829 |
|
2004 |
Zou Y, Gryaznov SM, Shay JW, Wright WE, Cornforth MN. Asynchronous replication timing of telomeres at opposite arms of mammalian chromosomes. Proceedings of the National Academy of Sciences of the United States of America. 101: 12928-33. PMID 15322275 DOI: 10.1073/Pnas.0404106101 |
0.609 |
|
2004 |
Vaughan MB, Ramirez RD, Brown SA, Yang JC, Wright WE, Shay JW. A reproducible laser-wounded skin equivalent model to study the effects of aging in vitro. Rejuvenation Research. 7: 99-110. PMID 15312297 DOI: 10.1089/1549168041552982 |
0.76 |
|
2004 |
Baur JA, Wright WE, Shay JW. Analysis of mammalian telomere position effect. Methods in Molecular Biology (Clifton, N.J.). 287: 121-36. PMID 15273408 DOI: 10.1385/1-59259-828-5:121 |
0.651 |
|
2004 |
Sunaga N, Miyajima K, Suzuki M, Sato M, White MA, Ramirez RD, Shay JW, Gazdar AF, Minna JD. Different roles for caveolin-1 in the development of non-small cell lung cancer versus small cell lung cancer Cancer Research. 64: 4277-4285. PMID 15205342 DOI: 10.1158/0008-5472.Can-03-3941 |
0.391 |
|
2004 |
Troester MA, Hoadley KA, Sørlie T, Herbert BS, Børresen-Dale AL, Lønning PE, Shay JW, Kaufmann WK, Perou CM. Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Research. 64: 4218-26. PMID 15205334 DOI: 10.1158/0008-5472.Can-04-0107 |
0.409 |
|
2004 |
Nishi H, Nakada T, Kyo S, Inoue M, Shay JW, Isaka K. Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT) Molecular and Cellular Biology. 24: 6076-6083. PMID 15199161 DOI: 10.1128/Mcb.24.13.6076-6083.2004 |
0.321 |
|
2004 |
Zhang H, Herbert BS, Pan KH, Shay JW, Cohen SN. Disparate effects of telomere attrition on gene expression during replicative senescence of human mammary epithelial cells cultured under different conditions. Oncogene. 23: 6193-8. PMID 15195144 DOI: 10.1038/Sj.Onc.1207834 |
0.424 |
|
2004 |
Zou Y, Sfeir A, Gryaznov SM, Shay JW, Wright WE. Does a sentinel or a subset of short telomeres determine replicative senescence? Molecular Biology of the Cell. 15: 3709-18. PMID 15181152 DOI: 10.1091/Mbc.E04-03-0207 |
0.671 |
|
2004 |
Forsyth NR, Morales CP, Damle S, Boman B, Wright WE, Kopelovich L, Shay JW. Spontaneous immortalization of clinically normal colon-derived fibroblasts from a familial adenomatous polyposis patient. Neoplasia (New York, N.Y.). 6: 258-65. PMID 15153338 DOI: 10.1593/Neo.04103 |
0.674 |
|
2004 |
Bechter OE, Zou Y, Walker W, Wright WE, Shay JW. Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition. Cancer Research. 64: 3444-51. PMID 15150096 DOI: 10.1158/0008-5472.Can-04-0323 |
0.683 |
|
2004 |
Shay JW, Wright WE. Telomeres are double-strand DNA breaks hidden from DNA damage responses. Molecular Cell. 14: 420-1. PMID 15149591 DOI: 10.1016/S1097-2765(04)00269-2 |
0.622 |
|
2004 |
Steinert S, Shay JW, Wright WE. Modification of subtelomeric DNA. Molecular and Cellular Biology. 24: 4571-80. PMID 15121873 DOI: 10.1128/Mcb.24.10.4571-4580.2004 |
0.584 |
|
2004 |
Shay JW, Wright WE. Telomeres in dyskeratosis congenita. Nature Genetics. 36: 437-8. PMID 15118675 DOI: 10.1038/Ng0504-437 |
0.593 |
|
2004 |
Shay JW, Roninson IB. Hallmarks of senescence in carcinogenesis and cancer therapy Oncogene. 23: 2919-2933. PMID 15077154 DOI: 10.1038/Sj.Onc.1207518 |
0.428 |
|
2004 |
Bechter OE, Shay JW, Wright WE. The frequency of homologous recombination in human ALT cells. Cell Cycle (Georgetown, Tex.). 3: 547-9. PMID 15034305 DOI: 10.4161/Cc.3.5.850 |
0.654 |
|
2004 |
Walter M, Forsyth NR, Wright WE, Shay JW, Roth MG. The establishment of telomerase-immortalized Tangier disease cell lines indicates the existence of an apolipoprotein A-I-inducible but ABCA1-independent cholesterol efflux pathway. The Journal of Biological Chemistry. 279: 20866-73. PMID 15001567 DOI: 10.1074/Jbc.M401714200 |
0.619 |
|
2004 |
Baur JA, Shay JW, Wright WE. Spontaneous reactivation of a silent telomeric transgene in a human cell line. Chromosoma. 112: 240-6. PMID 14735368 DOI: 10.1007/S00412-003-0269-X |
0.662 |
|
2003 |
Herbert BS, Shay JW, Wright WE. Analysis of telomeres and telomerase. Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [Et Al.]. Unit 18.6. PMID 18228424 DOI: 10.1002/0471143030.Cb1806S20 |
0.675 |
|
2003 |
Hiyama E, Hiyama K, Nishiyama M, Partrik Reynolds C, Shay JW, Yokoyama T. Differential Gene Expression Profiles between Neuroblastomas with High Telomerase Activity and Low Telomerase Activity Journal of Pediatric Surgery. 38: 1730-1734. PMID 14666454 DOI: 10.1016/J.Jpedsurg.2003.08.042 |
0.358 |
|
2003 |
Bechter OE, Zou Y, Shay JW, Wright WE. Homologous recombination in human telomerase-positive and ALT cells occurs with the same frequency. Embo Reports. 4: 1138-43. PMID 14618159 DOI: 10.1038/Sj.Embor.7400027 |
0.651 |
|
2003 |
Forsyth NR, Evans AP, Shay JW, Wright WE. Developmental differences in the immortalization of lung fibroblasts by telomerase. Aging Cell. 2: 235-43. PMID 14570231 DOI: 10.1046/J.1474-9728.2003.00057.X |
0.599 |
|
2003 |
Velicescu M, Yu J, Herbert BS, Shay JW, Granada E, Dubeau L. Aneuploidy and telomere attrition are independent determinants of crisis in SV40-transformed epithelial cells Cancer Research. 63: 5813-5820. PMID 14522904 |
0.357 |
|
2003 |
Wu X, Amos CI, Zhu Y, Zhao H, Grossman BH, Shay JW, Luo S, Hong WK, Spitz MR. Telomere dysfunction: A potential cancer predisposition factor Journal of the National Cancer Institute. 95: 1211-1218. PMID 12928346 DOI: 10.1093/Jnci/Djg011 |
0.382 |
|
2003 |
Jester JV, Huang J, Fisher S, Spiekerman J, Chang JH, Wright WE, Shay JW. Myofibroblast differentiation of normal human keratocytes and hTERT, extended-life human corneal fibroblasts. Investigative Ophthalmology & Visual Science. 44: 1850-8. PMID 12714615 DOI: 10.1167/Iovs.02-0973 |
0.63 |
|
2003 |
Herbert BS, Pearce VP, Hynan LS, LaRue DM, Wright WE, Kopelovich L, Shay JW. A peroxisome proliferator-activated receptor-gamma agonist and the p53 rescue drug CP-31398 inhibit the spontaneous immortalization of breast epithelial cells. Cancer Research. 63: 1914-9. PMID 12702583 |
0.597 |
|
2003 |
Sengupta S, Linke SP, Pedeux R, Yang Q, Farnsworth J, Garfield SH, Valerie K, Shay JW, Ellis NA, Wasylyk B, Harris CC. BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination. The Embo Journal. 22: 1210-22. PMID 12606585 DOI: 10.1093/Emboj/Cdg114 |
0.334 |
|
2003 |
Zhang X, Multani AS, Zhou JH, Shay JW, McConkey D, Dong L, Kim CS, Rosser CJ, Pathak S, Benedict WF. Adenoviral-mediated retinoblastoma 94 produces rapid telomere erosion, chromosomal crisis, and caspase-dependent apoptosis in bladder cancer and immortalized human urothelial cells but not in normal urothelial cells Cancer Research. 63: 760-765. PMID 12591722 |
0.402 |
|
2003 |
Morales CP, Gandia KG, Ramirez RD, Wright WE, Shay JW, Spechler SJ. Characterisation of telomerase immortalised normal human oesophageal squamous cells Gut. 52: 327-333. PMID 12584211 DOI: 10.1136/Gut.52.3.327 |
0.454 |
|
2003 |
Ramirez RD, Herbert BS, Vaughan MB, Zou Y, Gandia K, Morales CP, Wright WE, Shay JW. Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells Oncogene. 22: 433-444. PMID 12545164 DOI: 10.1038/Sj.Onc.1206046 |
0.821 |
|
2003 |
Sharma GG, Gupta A, Wang H, Scherthan H, Dhar S, Gandhi V, Iliakis G, Shay JW, Young CS, Pandita TK. hTERT associates with human telomeres and enhances genomic stability and DNA repair. Oncogene. 22: 131-46. PMID 12527915 DOI: 10.1038/Sj.Onc.1206063 |
0.444 |
|
2003 |
Ramirez RD, Kurie J, DiMaio JM, Vaughan MB, Milchgrub S, Smith A, Gandia G, Sheridan S, Shay JW, Minna JD. O-205 Immortalization of normal human bronchial epithelial cells (NHBEC) in the absence of viral oncoproteins Lung Cancer. 41. DOI: 10.1016/S0169-5002(03)91863-0 |
0.356 |
|
2002 |
Zou Y, Yi X, Wright WE, Shay JW. Human telomerase can immortalize Indian muntjac cells Experimental Cell Research. 281: 63-76. PMID 12441130 DOI: 10.1006/Excr.2002.5645 |
0.686 |
|
2002 |
Herbert BS, Wright WE, Shay JW. p16INK4a inactivation is not required to immortalize human mammary epithelial cells Oncogene. 21: 7897-7900. PMID 12420227 DOI: 10.1038/Sj.Onc.1205902 |
0.624 |
|
2002 |
Shay JW, Wright WE. Telomerase: A target for cancer therapeutics Cancer Cell. 2: 257-265. PMID 12398889 DOI: 10.1016/S1535-6108(02)00159-9 |
0.611 |
|
2002 |
Chai W, Ford LP, Lenertz L, Wright WE, Shay JW. Human Ku70/80 associates physically with telomerase through interaction with hTERT. The Journal of Biological Chemistry. 277: 47242-7. PMID 12377759 DOI: 10.1074/Jbc.M208542200 |
0.656 |
|
2002 |
Cong YS, Wright WE, Shay JW. Human telomerase and its regulation Microbiology and Molecular Biology Reviews. 66: 407-425. PMID 12208997 DOI: 10.1128/Mmbr.66.3.407-425.2002 |
0.676 |
|
2002 |
Condon J, Yin S, Mayhew B, Word RA, Wright WE, Shay JW, Rainey WE. Telomerase immortalization of human myometrial cells. Biology of Reproduction. 67: 506-14. PMID 12135889 DOI: 10.1095/Biolreprod67.2.506 |
0.424 |
|
2002 |
Wright WE, Shay JW. Historical claims and current interpretations of replicative aging Nature Biotechnology. 20: 682-688. PMID 12089552 DOI: 10.1038/Nbt0702-682 |
0.639 |
|
2002 |
Shea-Herbert B, Pongracz K, Shay JW, Gryaznov SM. Oligonucleotide N3'-->P5' phosphoramidates as efficient telomerase inhibitors. Oncogene. 21: 638-642. PMID 11850790 DOI: 10.1038/Sj.Onc.1205064 |
0.449 |
|
2002 |
Ford LP, Wright WE, Shay JW. A model for heterogeneous nuclear ribonucleoproteins in telomere and telomerase regulation Oncogene. 21: 580-583. PMID 11850782 DOI: 10.1038/Sj.Onc.1205086 |
0.643 |
|
2002 |
Forsyth NR, Wright WE, Shay JW. Telomerase and differentiation in multicellular organisms: Turn it off, turn it on, and turn it off again Differentiation. 69: 188-197. PMID 11841477 DOI: 10.1046/J.1432-0436.2002.690412.X |
0.665 |
|
2002 |
Granger MP, Wright WE, Shay JW. Telomerase in cancer and aging. Critical Reviews in Oncology/Hematology. 41: 29-40. PMID 11796230 DOI: 10.1016/S1040-8428(01)00188-3 |
0.676 |
|
2002 |
Aisner DL, Wright WE, Shay JW. Telomerase regulation: Not just flipping the switch Current Opinion in Genetics and Development. 12: 80-85. PMID 11790559 DOI: 10.1016/S0959-437X(01)00268-4 |
0.599 |
|
2002 |
Steinert S, White DM, Zou Y, Shay JW, Wright WE. Telomere biology and cellular aging in nonhuman primate cells. Experimental Cell Research. 272: 146-52. PMID 11777339 DOI: 10.1006/Excr.2001.5409 |
0.671 |
|
2001 |
Yi X, Shay JW, Wright WE. Quantitation of telomerase components and hTERT mRNA splicing patterns in immortal human cells Nucleic Acids Research. 29: 4818-4825. PMID 11726691 DOI: 10.1093/Nar/29.23.4818 |
0.469 |
|
2001 |
Yang L, Suwa T, Wright WE, Shay JW, Hornsby PJ. Telomere shortening and decline in replicative potential as a function of donor age in human adrenocortical cells. Mechanisms of Ageing and Development. 122: 1685-94. PMID 11557273 DOI: 10.1016/S0047-6374(01)00280-9 |
0.477 |
|
2001 |
Ford LP, Shay JW, Wright WE. The La antigen associates with the human telomerase ribonucleoprotein and influences telomere length in vivo Rna. 7: 1068-1075. PMID 11497426 DOI: 10.1017/S1355838201010159 |
0.476 |
|
2001 |
Baur JA, Zou Y, Shay JW, Wright WE. Telomere position effect in human cells Science. 292: 2075-2077. PMID 11408657 DOI: 10.1126/Science.1062329 |
0.463 |
|
2001 |
Ford LP, Zou Y, Pongracz K, Gryaznov SM, Shay JW, Wright WE. Telomerase can inhibit the recombination-based pathway of telomere maintenance in human cells. The Journal of Biological Chemistry. 276: 32198-203. PMID 11395519 DOI: 10.1074/Jbc.M104469200 |
0.477 |
|
2001 |
Hiyama E, Hiyama K, Yokoyama T, Shay JW. Immunohistochemical Detection of Telomerase (hTERT) Protein in Human Cancer Tissues and a Subset of Cells in Normal Tissues Neoplasia. 3: 17-26. PMID 11326312 DOI: 10.1038/Sj.Neo.7900134 |
0.468 |
|
2001 |
Nishimoto A, Miura N, Horikawa I, Kugoh H, Murakami Y, Hirohashi S, Kawasaki H, Gazdar AF, Shay JW, Barrett JC, Oshimura M. Functional evidence for a telomerase repressor gene on human chromosome 10p15.1. Oncogene. 20: 828-835. PMID 11314017 DOI: 10.1038/Sj.Onc.1204165 |
0.392 |
|
2001 |
Wood LD, Halvorsen TL, Dhar S, Baur JA, Pandita RK, Wright WE, Hande MP, Calaf G, Hei TK, Levine F, Shay JW, Wang JJ, Pandita TK. Characterization of ataxia telangiectasia fibroblasts with extended life-span through telomerase expression. Oncogene. 20: 278-88. PMID 11313956 DOI: 10.1038/Sj.Onc.1204072 |
0.374 |
|
2001 |
Herbert BS, Wright WE, Shay JW. Telomerase and breast cancer Breast Cancer Research. 3: 146-149. PMID 11305948 DOI: 10.1186/Bcr288 |
0.317 |
|
2001 |
Shay JW, Zou Y, Hiyama E, Wright WE. Telomerase and cancer Human Molecular Genetics. 10: 677-685. PMID 11257099 DOI: 10.1093/Hmg/10.7.677 |
0.42 |
|
2001 |
Ramirez RD, Morales CP, Herbert BS, Rohde JM, Passons C, Shay JW, Wright WE. Putative telomere-independent mechanisms of replicative aging reflect inadequate growth conditions. Genes & Development. 15: 398-403. PMID 11230148 DOI: 10.1101/Gad.859201 |
0.436 |
|
2001 |
Shay JW, Wright WE. When do telomeres matter? Science. 291: 839-840. PMID 11225633 DOI: 10.1126/Science.1058546 |
0.396 |
|
2001 |
Wright WE, Shay JW. Cellular senescence as a tumor-protection mechanism: The essential role of counting Current Opinion in Genetics and Development. 11: 98-103. PMID 11163158 DOI: 10.1016/S0959-437X(00)00163-5 |
0.385 |
|
2001 |
Herbert BS, Wright AC, Passons CM, Wright WE, Ali IU, Kopelovich L, Shay JW. Effects of Chemopreventive and Antitelomerase Agents on the Spontaneous Immortalization of Breast Epithelial Cells Journal of the National Cancer Institute. 93: 39-45. PMID 11136840 DOI: 10.1093/Jnci/93.1.39 |
0.411 |
|
2001 |
Shay JW, Wright WE. Telomeres and telomerase: Implications for cancer and aging Radiation Research. 155: 188-193. PMID 11121233 DOI: 10.1667/0033-7587(2001)155[0188:Tatifc]2.0.Co;2 |
0.522 |
|
2001 |
Shay JW, Wright WE. Forward: Aging and cancer: Are telomeres and telomerase the connection? Advances in Cell Aging and Gerontology. 8: 1-13. DOI: 10.1016/S1566-3124(01)08001-4 |
0.512 |
|
2001 |
Shay JW, Wright WE. Ageing and cancer: the telomere and telomerase connection. Novartis Foundation Symposium. 235: 116-129. DOI: 10.1002/0470868694.Ch11 |
0.508 |
|
2000 |
Shay JW, Wright WE. Hayflick, his limit, and cellular ageing Nature Reviews Molecular Cell Biology. 1: 72-76. PMID 11413492 DOI: 10.1038/35036093 |
0.356 |
|
2000 |
Yi X, White DM, Aisner DL, Baur JA, Wright WE, Shay JW. An alternate splicing variant of the human telomerase catalytic subunit inhibits telomerase activity. Neoplasia (New York, N.Y.). 2: 433-40. PMID 11191110 DOI: 10.1038/Sj.Neo.7900113 |
0.419 |
|
2000 |
Ford LP, Suh JM, Wright WE, Shay JW. Heterogeneous nuclear ribonucleoproteins C1 and C2 associate with the RNA component of human telomerase. Molecular and Cellular Biology. 20: 9084-91. PMID 11074006 DOI: 10.1128/Mcb.20.23.9084-9091.2000 |
0.316 |
|
2000 |
Hiyama E, Saeki T, Hiyama K, Takashima S, Shay JW, Matsuura Y, Yokoyama T. Telomerase activity as a marker of breast carcinoma in fine-needle aspirated samples Cancer. 90: 235-238. PMID 10966564 DOI: 10.1002/1097-0142(20000825)90:4<235::Aid-Cncr6>3.0.Co;2-Z |
0.334 |
|
2000 |
McChesney PA, Aisner DL, Frank BC, Wright WE, Shay JW. Telomere dynamics in cells with introduced telomerase: A rapid assay for telomerase activity on telomeres Molecular Cell Biology Research Communications. 3: 312-318. PMID 10964756 DOI: 10.1006/Mcbr.2000.0229 |
0.492 |
|
2000 |
Shay JW, Wright WE. Implications of mapping the human telomerase gene (hTERT) as the most distal gene on chromosome 5p Neoplasia. 2: 195-196. PMID 10935504 DOI: 10.1038/Sj.Neo.7900093 |
0.494 |
|
2000 |
Ramirez RD, D'Atri S, Pagani E, Faraggiana T, Lacal PM, Taylor RS, Shay JW. Progressive increase in telomerase activity from benign melanocytic conditions to malignant melanoma. Neoplasia (New York, N.Y.). 1: 42-9. PMID 10935469 DOI: 10.1038/Sj.Neo.7900004 |
0.326 |
|
2000 |
Wright WE, Shay JW. Telomere dynamics in cancer progression and prevention: Fundamental differences in human and mouse telomere biology Nature Medicine. 6: 849-851. PMID 10932210 DOI: 10.1038/78592 |
0.44 |
|
2000 |
Steinert S, Shay JW, Wright WE. Transient expression of human telomerase extends the life span of normal human fibroblasts Biochemical and Biophysical Research Communications. 273: 1095-1098. PMID 10891377 DOI: 10.1006/Bbrc.2000.3080 |
0.442 |
|
2000 |
Zhao S, Weng YC, Yuan SS, Lin YT, Hsu HC, Lin SC, Gerbino E, Song MH, Zdzienicka MZ, Gatti RA, Shay JW, Ziv Y, Shiloh Y, Lee EY. Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products. Nature. 405: 473-7. PMID 10839544 DOI: 10.1038/35013083 |
0.357 |
|
2000 |
Huffman KE, Levene SD, Tesmer VM, Shay JW, Wright WE. Telomere shortening is proportional to the size of the G-rich telomeric 3'-overhang. The Journal of Biological Chemistry. 275: 19719-22. PMID 10787419 DOI: 10.1074/Jbc.M002843200 |
0.455 |
|
2000 |
Ouellette MM, Liao M, Herbert BS, Johnson M, Holt SE, Liss HS, Shay JW, Wright WE. Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase. The Journal of Biological Chemistry. 275: 10072-6. PMID 10744686 DOI: 10.1074/Jbc.275.14.10072 |
0.713 |
|
2000 |
Ouellette MM, McDaniel LD, Wright WE, Shay JW, Schultz RA. The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes Human Molecular Genetics. 9: 403-411. PMID 10655550 DOI: 10.1093/Hmg/9.3.403 |
0.436 |
|
2000 |
Shay JW, Wright WE. The use of telomerized cells for tissue engineering Nature Biotechnology. 18: 22-23. PMID 10625382 DOI: 10.1038/71872 |
0.32 |
|
1999 |
Shay JW, Wright WE. Mutant dyskerin ends relationship with telomerase Science. 286: 2284-2285. PMID 10636790 DOI: 10.1126/Science.286.5448.2284 |
0.35 |
|
1999 |
Herbert B, Pitts AE, Baker SI, Hamilton SE, Wright WE, Shay JW, Corey DR. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proceedings of the National Academy of Sciences of the United States of America. 96: 14276-81. PMID 10588696 DOI: 10.1073/Pnas.96.25.14276 |
0.454 |
|
1999 |
Shay JW. At the end of the millennium, a view of the end. Nature Genetics. 23: 382-383. PMID 10581016 DOI: 10.1038/70480 |
0.489 |
|
1999 |
Itoi T, Ohyashiki K, Yahata N, Shinohara Y, Takei K, Takeda K, Nagao K, Hisatomi H, Ebihara Y, Shay JW, Saito T. Detection of telomerase activity in exfoliated cancer cells obtained from bile International Journal of Oncology. 15: 1061-1067. PMID 10568809 DOI: 10.3892/Ijo.15.6.1061 |
0.394 |
|
1999 |
Wright WE, Tesmer VM, Liao ML, Shay JW. Normal human telomeres are not late replicating. Experimental Cell Research. 251: 492-499. PMID 10471333 DOI: 10.1006/Excr.1999.4602 |
0.452 |
|
1999 |
Tesmer VM, Ford LP, Holt SE, Frank BC, Yi X, Aisner DL, Ouellette M, Shay JW, Wright WE. Two inactive fragments of the integral RNA cooperate to assemble active telomerase with the human protein catalytic subunit (hTERT) in vitro. Molecular and Cellular Biology. 19: 6207-16. PMID 10454567 DOI: 10.1128/Mcb.19.9.6207 |
0.66 |
|
1999 |
Lavranos TC, Mathis JM, Latham SE, Kalionis B, Shay JW, Rodgers RJ. Evidence for ovarian granulosa stem cells: telomerase activity and localization of the telomerase ribonucleic acid component in bovine ovarian follicles. Biology of Reproduction. 61: 358-66. PMID 10411512 DOI: 10.1095/Biolreprod61.2.358 |
0.428 |
|
1999 |
Holt SE, Shay JW. Role of telomerase in cellular proliferation and cancer. Journal of Cellular Physiology. 180: 10-8. PMID 10362013 DOI: 10.1002/(Sici)1097-4652(199907)180:1<10::Aid-Jcp2>3.0.Co;2-D |
0.749 |
|
1999 |
Yi X, Tesmer VM, Savre-Train I, Shay JW, Wright WE. Both Transcriptional and Posttranscriptional Mechanisms Regulate Human Telomerase Template RNA Levels Molecular and Cellular Biology. 19: 3989-3997. PMID 10330139 DOI: 10.1128/Mcb.19.6.3989 |
0.435 |
|
1999 |
Holt SE, Aisner DL, Baur J, Tesmer VM, Dy M, Ouellette M, Trager JB, Morin GB, Toft DO, Shay JW, Wright WE, White MA. Functional requirement of p23 and Hsp90 in telomerase complexes. Genes & Development. 13: 817-26. PMID 10197982 DOI: 10.1101/Gad.13.7.817 |
0.669 |
|
1999 |
Maitra A, Yashima K, Rathi A, CFTMD, Rogers BB, Shay JW, Gazdar AF. The RNA component of telomerase as a marker of biologic potential and clinical outcome in childhood neuroblastic tumors Cancer. 85: 741-749. PMID 10091748 DOI: 10.1002/(Sici)1097-0142(19990201)85:3<741::Aid-Cncr25>3.0.Co;2-6 |
0.329 |
|
1999 |
Ouellette MM, Aisner DL, Savre-Train I, Wright WE, Shay JW. Telomerase activity does not always imply telomere maintenance Biochemical and Biophysical Research Communications. 254: 795-803. PMID 9920820 DOI: 10.1006/Bbrc.1998.0114 |
0.382 |
|
1999 |
Morales CP, Holt SE, Ouellette M, Kaur KJ, Yan Y, Wilson KS, White MA, Wright WE, Shay JW. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase. Nature Genetics. 21: 115-8. PMID 9916803 DOI: 10.1038/5063 |
0.707 |
|
1999 |
Shay JW. Toward Identifying A Cellular Determinant Of Telomerase Repression Journal of the National Cancer Institute. 91: 4-6. PMID 9890161 DOI: 10.1093/Jnci/91.1.4 |
0.322 |
|
1999 |
Muller M, Krause H, Heicappell R, Tischendorf J, Shay JW, Miller K. Comparison of Human Telomerase RNA and Telomerase Activity in Urine for Diagnosis of Bladder Cancer The Journal of Urology. 161: 1714-1714. DOI: 10.1016/S0022-5347(05)69011-8 |
0.36 |
|
1998 |
Gazdar AF, Kurvari V, Virmani A, Gollahon L, Sakaguchi M, Westerfield M, Kodagoda D, Stasny V, Cunningham HT, Wistuba II, Tomlinson G, Tonk V, Ashfaq R, Leitch AM, Minna JD, ... Shay JW, et al. Characterization of paired tumor and non-tumor cell lines established from patients with breast cancer. International Journal of Cancer. Journal International Du Cancer. 78: 766-74. PMID 9833771 DOI: 10.1002/(Sici)1097-0215(19981209)78:6<766::Aid-Ijc15>3.0.Co;2-L |
0.351 |
|
1998 |
Morales CP, Burdick JS, Saboorian MH, Wright WE, Shay JW. In situ hybridization for telomerase RNA in routine cytologic brushings for the diagnosis of pancreaticobiliary malignancies. Gastrointestinal Endoscopy. 48: 402-5. PMID 9786114 DOI: 10.1016/S0016-5107(98)70011-2 |
0.301 |
|
1998 |
Gollahon LS, Kraus E, Wu TA, Yim SO, Strong LC, Shay JW, Tainsky MA. Telomerase activity during spontaneous immortalization of Li-Fraumeni syndrome skin fibroblasts Oncogene. 17: 709-717. PMID 9715272 DOI: 10.1038/Sj.Onc.1201987 |
0.446 |
|
1998 |
Morales CP, Lee EL, Shay JW. In situ hybridization for the detection of telomerase RNA in the progression from Barrett's esophagus to esophageal adenocarcinoma. Cancer. 83: 652-9. PMID 9708927 DOI: 10.1002/(Sici)1097-0142(19980815)83:4<652::Aid-Cncr4>3.0.Co;2-M |
0.35 |
|
1998 |
Iwama H, Ohyashiki K, Ohyashiki JH, Hayashi S, Yahata N, Ando K, Toyama K, Hoshika A, Takasaki M, Mori M, Shay JW. Telomeric length and telomerase activity vary with age in peripheral blood cells obtained from normal individuals. Human Genetics. 102: 397-402. PMID 9600234 DOI: 10.1007/S004390050711 |
0.351 |
|
1998 |
Yashima K, Maitra A, Timmons CF, Rogers BB, Pinar H, Shay JW, Gazdar AF. Expression of the RNA component of telomerase in wilms tumor and nephrogenic rest recapitulates renal embryogenesis Human Pathology. 29: 536-542. PMID 9596280 DOI: 10.1016/S0046-8177(98)90072-7 |
0.312 |
|
1998 |
Yahata N, Ohyashiki K, Ohyashiki JH, Iwama H, Hayashi S, Ando K, Hirano T, Tsuchida T, Kato H, Shay JW, Toyama K. Telomerase activity in lung cancer cells obtained from bronchial washings. Journal of the National Cancer Institute. 90: 684-90. PMID 9586665 DOI: 10.1093/Jnci/90.9.684 |
0.401 |
|
1998 |
Ogoshi M, Le T, Shay JW, Taylor RS. In Situ Hybridization Analysis of the Expression of Human Telomerase RNA in Normal and Pathologic Conditions of the Skin Journal of Investigative Dermatology. 110: 818-823. PMID 9579552 DOI: 10.1046/J.1523-1747.1998.00180.X |
0.399 |
|
1998 |
Norton JC, Holt SE, Wright WE, Shay JW. Enhanced detection of human telomerase activity. Dna and Cell Biology. 17: 217-9. PMID 9539101 DOI: 10.1089/Dna.1998.17.217 |
0.655 |
|
1998 |
Yashima K, Ashfaq R, Nowak J, Gruenigen VV, Milchgrub S, Rathi A, Albores-Saavedra J, Shay JW, Gazdar AF. Telomerase activity and expression of its RNA component in cervical lesions Cancer. 82: 1319-1327. PMID 9529024 DOI: 10.1002/(Sici)1097-0142(19980401)82:7<1319::Aid-Cncr15>3.0.Co;2-9 |
0.302 |
|
1998 |
Pearson AS, Gollahon LS, O'Neal NC, Saboorian H, Shay JW, Fahey TJ. Detection of telomerase activity in breast masses by fine-needle aspiration Annals of Surgical Oncology. 5: 186-193. PMID 9527273 DOI: 10.1007/Bf02303853 |
0.345 |
|
1998 |
Bodnar AG, Ouellette M, Frolkis M, Holt SE, Chiu CP, Morin GB, Harley CB, Shay JW, Lichtsteiner S, Wright WE. Extension of life-span by introduction of telomerase into normal human cells. Science (New York, N.Y.). 279: 349-52. PMID 9454332 DOI: 10.1126/Science.279.5349.349 |
0.718 |
|
1998 |
Shay JW. Aging and cancer: are telomeres and telomerase the connection? Molecular Medicine Today. 1: 378-84. PMID 9415184 DOI: 10.1016/S1357-4310(95)93872-9 |
0.46 |
|
1998 |
Hiyama K, Ishioka S, Shay JW, Taooka Y, Maeda A, Isobe T, Hiyama E, Maeda H, Yamakido M. Telomerase activity as a novel marker of lung cancer and immune-associated lung diseases. International Journal of Molecular Medicine. 1: 545-549. DOI: 10.3892/Ijmm.1.3.545 |
0.383 |
|
1997 |
Shay JW, Werbin H, Wright WE. Telomerase assays in the diagnosis and prognosis of cancer Ciba Foundation Symposia. 148-159. PMID 9524756 DOI: 10.1002/9780470515433.CH10 |
0.304 |
|
1997 |
Hiyama E, Hiyama K, Ohtsu K, Yamaoka H, Ichikawa T, Shay JW, Yokoyama T. Telomerase activity in neuroblastoma: is it a prognostic indicator of clinical behaviour? European Journal of Cancer. 33: 1932-1936. PMID 9516827 DOI: 10.1016/S0959-8049(97)00226-8 |
0.344 |
|
1997 |
Shay JW. Molecular Pathogenesis Of Aging And Cancer : Are Telomeres And Telomerase The Connection? Journal of Clinical Pathology. 50: 799-800. PMID 9462257 DOI: 10.1136/Jcp.50.10.799 |
0.364 |
|
1997 |
Brown DF, Gazdar AF, White CL, Yashima K, Shay JW, Rushing EJ. Human telomerase RNA expression and MIB-1 (Ki-67) proliferation index distinguish hemangioblastomas from metastatic renal cell carcinomas. Journal of Neuropathology and Experimental Neurology. 56: 1349-55. PMID 9413283 DOI: 10.1016/S0022-5347(01)62490-X |
0.327 |
|
1997 |
Weinrich SL, Pruzan R, Ma L, Ouellette M, Tesmer VM, Holt SE, Bodnar AG, Lichtsteiner S, Kim NW, Trager JB, Taylor RD, Carlos R, Andrews WH, Wright WE, Shay JW, et al. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nature Genetics. 17: 498-502. PMID 9398860 DOI: 10.1038/Ng1297-498 |
0.724 |
|
1997 |
Holt SE, Aisner DL, Shay JW, Wright WE. Lack of cell cycle regulation of telomerase activity in human cells. Proceedings of the National Academy of Sciences of the United States of America. 94: 10687-92. PMID 9380696 DOI: 10.1073/Pnas.94.20.10687 |
0.701 |
|
1997 |
Shay JW. Telomerase in human development and cancer. Journal of Cellular Physiology. 173: 266-70. PMID 9365534 DOI: 10.1002/(Sici)1097-4652(199711)173:2<266::Aid-Jcp33>3.0.Co;2-B |
0.464 |
|
1997 |
Iwao T, Hiyama E, Yokoyama T, Tsuchida A, Hiyama K, Murakami Y, Shimamoto F, Shay JW, Kajiyama G. Telomerase Activity for the Preoperative Diagnosis of Pancreatic Cancer Journal of the National Cancer Institute. 89: 1621-1623. PMID 9362161 DOI: 10.1093/Jnci/89.21.1621 |
0.302 |
|
1997 |
Wright WE, Tesmer VM, Huffman KE, Levene SD, Shay JW. Normal human chromosomes have long G-rich telomeric overhangs at one end. Genes & Development. 11: 2801-9. PMID 9353250 DOI: 10.1101/Gad.11.21.2801 |
0.459 |
|
1997 |
Rushing EJ, Yashima K, Brown DF, White CL, Shay JW, Risser RC, Gazdar AF. Expression of telomerase RNA component correlates with the MIB-1 proliferation index in ependymomas. Journal of Neuropathology and Experimental Neurology. 56: 1142-6. PMID 9329458 DOI: 10.1097/00005072-199710000-00008 |
0.355 |
|
1997 |
Hamilton SE, Pitts AE, Katipally RR, Jia X, Rutter JP, Davies BA, Shay JW, Wright WE, Corey DR. Identification of determinants for inhibitor binding within the RNA active site of human telomerase using PNA scanning. Biochemistry. 36: 11873-80. PMID 9305980 DOI: 10.1021/Bi970438K |
0.316 |
|
1997 |
Shay JW, Bacchetti S. A survey of telomerase activity in human cancer. European Journal of Cancer (Oxford, England : 1990). 33: 787-91. PMID 9282118 DOI: 10.1016/S0959-8049(97)00062-2 |
0.38 |
|
1997 |
Holt SE, Wright WE, Shay JW. Multiple pathways for the regulation of telomerase activity. European Journal of Cancer (Oxford, England : 1990). 33: 761-6. PMID 9282114 DOI: 10.1016/S0959-8049(97)00066-X |
0.744 |
|
1997 |
Coursen JD, Bennett WP, Gollahon L, Shay JW, Harris CC. Genomic instability and telomerase activity in human bronchial epithelial cells during immortalization by human papillomavirus-16 E6 and E7 genes. Experimental Cell Research. 235: 245-53. PMID 9281374 DOI: 10.1006/Excr.1997.3670 |
0.338 |
|
1997 |
Roque RS, Agarwal N, Wordinger RJ, Brun AM, Xue Y, Huang LC, Nguyen LP, Shay JW. Human papillomavirus-16 E6/E7 transfected retinal cell line expresses the Müller cell phenotype. Experimental Eye Research. 64: 519-27. PMID 9227269 DOI: 10.1006/Exer.1996.0230 |
0.374 |
|
1997 |
Yan Y, Shay JW, Wright WE, Mumby MC. Inhibition of protein phosphatase activity induces p53-dependent apoptosis in the absence of p53 transactivation. The Journal of Biological Chemistry. 272: 15220-6. PMID 9182545 DOI: 10.1074/Jbc.272.24.15220 |
0.316 |
|
1997 |
Yashima K, Piatyszek MA, Saboorian HM, Virmani AK, Brown D, Shay JW, Gazdar AF. Telomerase activity and in situ telomerase RNA expression in malignant and non-malignant lymph nodes. Journal of Clinical Pathology. 50: 110-7. PMID 9155690 DOI: 10.1136/Jcp.50.2.110 |
0.37 |
|
1997 |
Shay JW, Gazdar AF. Telomerase in the early detection of cancer. Journal of Clinical Pathology. 50: 106-9. PMID 9155689 DOI: 10.1136/Jcp.50.2.106 |
0.356 |
|
1997 |
Breslow RA, Shay JW, Gazdar AF, Srivastava S. Telomerase and early detection of cancer: a National Cancer Institute workshop. Journal of the National Cancer Institute. 89: 618-23. PMID 9150185 DOI: 10.1093/Jnci/89.9.618 |
0.314 |
|
1997 |
Iwama H, Ohyashiki K, Ohyashiki JH, Hayashi S, Kawakubo K, Shay JW, Toyama K. The relationship between telomere length and therapy-associated cytogenetic responses in patients with chronic myeloid leukemia. Cancer. 79: 1552-60. PMID 9118038 DOI: 10.1002/(Sici)1097-0142(19970415)79:8<1552::Aid-Cncr17>3.0.Co;2-X |
0.334 |
|
1997 |
Langford LA, Piatyszek MA, Xu R, Schold SC, Wright WE, Shay JW. Telomerase activity in ordinary meningiomas predicts poor outcome. Human Pathology. 28: 416-20. PMID 9104940 DOI: 10.1016/S0046-8177(97)90029-0 |
0.357 |
|
1997 |
Pandita TK, Benvenuto JA, Shay JW, Pandita RK, Rakovitch E, Geard CR, Antman KH, Newman RA. Effect of penclomedine (NSC-338720) on telomere fusions, chromatin blebbing, and cell viability with and without telomerase activity and abrogated p53 function Biochemical Pharmacology. 53: 409-415. PMID 9065745 DOI: 10.1016/S0006-2952(96)00766-6 |
0.478 |
|
1997 |
Miura N, Horikawa I, Nishimoto A, Ohmura H, Ito H, Hirohashi S, Shay JW, Oshimura M. Progressive telomere shortening and telomerase reactivation during hepatocellular carcinogenesis Cancer Genetics and Cytogenetics. 93: 56-62. PMID 9062581 DOI: 10.1016/S0165-4608(96)00329-9 |
0.333 |
|
1997 |
Ohyashiki K, Ohyashiki JH, Iwama H, Hayashi S, Shay JW, Toyama K. Telomerase activity and cytogenetic changes in chronic myeloid leukemia with disease progression. Leukemia. 11: 190-4. PMID 9009079 DOI: 10.1038/Sj.Leu.2400560 |
0.332 |
|
1997 |
Ramirez RD, Wright WE, Shay JW, Taylor RS. Telomerase activity concentrates in the mitotically active segments of human hair follicles. Journal of Investigative Dermatology. 108: 113-117. PMID 8980299 DOI: 10.1111/1523-1747.Ep12285654 |
0.443 |
|
1997 |
Atri SD, Pagani E, Lacal PM, Nunziata C, Laurenza M, Macchini V, Baliva G, Faraggiana T, Passarelli F, Atzori F, Bonmassar E, Shay JW. Telomerase activity in human nevi and melanomas: 293 Melanoma Research. 7. DOI: 10.1097/00008390-199706001-00293 |
0.341 |
|
1997 |
Rushing EJ, Brown D, Ynshima K, White CL, Hladik CL, Mickey BE, Shay JW, Gazdar AF. COMPARISON OF Ki-67 ACTIVITY AND EXPRESSION OF THE RNA COMPONENT OF HUMAN TELOMERASE(hTR) IN EPENDYMOMAS Journal of Neuropathology and Experimental Neurology. 56: 583. DOI: 10.1097/00005072-199705000-00060 |
0.322 |
|
1997 |
Gazdar AF, Yashima K, Shay J. Telomerase dysregulation during the multistage pathogenesis of lung cancer Lung Cancer. 18: 40. DOI: 10.1016/S0169-5002(97)83882-2 |
0.308 |
|
1996 |
Ohyashiki K, Ohyashiki JH, Iwama H, Hayashi S, Shay JW, Toyama K. Telomerase reactivation in leukemia cells International Journal of Oncology. 8: 417-421. PMID 21544377 DOI: 10.3892/Ijo.8.3.417 |
0.436 |
|
1996 |
Hiyama E, Tatsumoto N, Kodama T, Hiyama K, Shay J, Yokoyama T. Telomerase activity in human intestine International Journal of Oncology. 9: 453-458. PMID 21541534 DOI: 10.3892/Ijo.9.3.453 |
0.478 |
|
1996 |
Holt SE, Shay JW, Wright WE. Refining the telomere-telomerase hypothesis of aging and cancer. Nature Biotechnology. 14: 836-9. PMID 9631006 DOI: 10.1038/Nbt0796-836 |
0.664 |
|
1996 |
Norton JC, Piatyszek MA, Wright WE, Shay JW, Corey DR. Inhibition of human telomerase activity by peptide nucleic acids. Nature Biotechnology. 14: 615-9. PMID 9630953 DOI: 10.1038/Nbt0596-615 |
0.338 |
|
1996 |
Wright WE, Piatyszek MA, Rainey WE, Byrd W, Shay JW. Telomerase activity in human germline and embryonic tissues and cells. Developmental Genetics. 18: 173-9. PMID 8934879 DOI: 10.1002/(Sici)1520-6408(1996)18:2<173::Aid-Dvg10>3.0.Co;2-3 |
0.45 |
|
1996 |
Shay JW, Wright WE. The reactivation of telomerase activity in cancer progression Trends in Genetics. 12: 129-131. PMID 8901415 DOI: 10.1016/0168-9525(96)30018-8 |
0.358 |
|
1996 |
Shay JW, Wright WE. Telomerase activity in human cancer Current Opinion in Oncology. 8: 66-71. PMID 8868103 DOI: 10.1097/00001622-199601000-00012 |
0.508 |
|
1996 |
West MD, Shay JW, Wright WE, Linskens MHK. Altered expression of plasminogen activator and plasminogen activator inhibitor during cellular senescence Experimental Gerontology. 31: 175-193. PMID 8706787 DOI: 10.1016/0531-5565(95)02013-6 |
0.398 |
|
1996 |
Holt SE, Wright WE, Shay JW. Regulation of telomerase activity in immortal cell lines. Molecular and Cellular Biology. 16: 2932-9. PMID 8649404 DOI: 10.1128/Mcb.16.6.2932 |
0.72 |
|
1996 |
Taylor RS, Ramirez RD, Ogoshi M, Chaffins M, Piatyszek MA, Shay JW. Detection of Telomerase Activity in Malignant and Nonmalignant Skin Conditions Journal of Investigative Dermatology. 106: 759-765. PMID 8618017 DOI: 10.1111/1523-1747.Ep12345811 |
0.378 |
|
1996 |
Hiyama E, Gollahon L, Kataoka T, Kuroi K, Yokoyama T, Gazdar AF, Hiyama K, Piatyszek MA, Shay JW. Telomerase Activity in Human Breast Tumors Journal of the National Cancer Institute. 88: 116-122. PMID 8537972 DOI: 10.1093/Jnci/88.2.116 |
0.368 |
|
1996 |
Shay JW. Telomerase and cancer: Geron Telomerase and Cancer Symposium, Kamuela, Hawaii, USA, 10–14 August 1996 Trends in Genetics. 12: 486-487. DOI: 10.1016/0168-9525(96)30104-2 |
0.335 |
|
1996 |
Holt SE, Norton JC, Wright WE, Shay JW. Comparison of the telomeric repeat amplification protocol (TRAP) to the new TRAP-eze telomerase detection kit Methods in Cell Science. 18: 237-248. DOI: 10.1007/BF00132889 |
0.59 |
|
1996 |
Wright WE, Brasiskyte D, Piatyszek MA, Shay JW. Experimental elongation of telomeres extends the lifespan of immortal x normal cell hybrids. The Embo Journal. 15: 1734-1741. DOI: 10.1002/J.1460-2075.1996.Tb00519.X |
0.487 |
|
1995 |
Shay JW, Tomlinson G, Piatyszek MA, Gollahon LS. Spontaneous in vitro immortalization of breast epithelial cells from a patient with Li-Fraumeni syndrome. Molecular and Cellular Biology. 15: 425-32. PMID 7799951 DOI: 10.1128/Mcb.15.1.425 |
0.351 |
|
1995 |
Hiyama K, Hiyama E, Ishioka S, Yamakido M, Inai K, Gazdar AF, Piatyszek MA, Shay JW. Telomerase Activity in Small-Cell and Non–Small-Cell Lung Cancers Journal of the National Cancer Institute. 87: 895-902. PMID 7666478 DOI: 10.1093/Jnci/87.12.895 |
0.448 |
|
1995 |
Allsopp RC, Chang E, Kashefi-Aazam M, Rogaev EI, Piatyszek MA, Shay JW, Harley CB. Telomere shortening is associated with cell division in vitro and in vivo. Experimental Cell Research. 220: 194-200. PMID 7664836 DOI: 10.1006/Excr.1995.1306 |
0.485 |
|
1995 |
Hiyama E, Hiyama K, Yokoyama T, Matsuura Y, Piatyszek MA, Shay JW. Correlating telomerase activity levels with human neuroblastoma outcomes Nature Medicine. 1: 249-255. PMID 7585042 DOI: 10.1038/Nm0395-249 |
0.36 |
|
1995 |
Ohmura H, Tahara H, Suzuki M, Ide T, Shimizu M, Yoshida MA, Tahara E, Shay JW, Barrett JC, Oshimura M. Restoration of the cellular senescence program and repression of telomerase by human chromosome 3 Japanese Journal of Cancer Research. 86: 899-904. PMID 7493906 DOI: 10.1111/J.1349-7006.1995.Tb02998.X |
0.434 |
|
1995 |
Langford LA, Piatyszek MA, Xu R, Schold SC, Shay JW. Telomerase activity in human brain tumours. Lancet. 346: 1267-8. PMID 7475720 DOI: 10.1016/S0140-6736(95)91865-5 |
0.376 |
|
1995 |
Shay JW, Werbin H, Wright WE. You Haven't Heard the End of It: Telomere Loss May Link Human Aging with Cancer Canadian Journal On Aging / La Revue Canadienne Du Vieillissement. 14: 511-524. DOI: 10.1017/S0714980800009089 |
0.477 |
|
1995 |
Wright WE, Shay JW. Time, telomeres and tumours: is cellular senescence more than an anticancer mechanism? Trends in Cell Biology. 5: 293-297. DOI: 10.1016/S0962-8924(00)89044-3 |
0.418 |
|
1995 |
Shay JW, Wright WE. Mechanisms of escaping cellular senescence Radiation Oncology Investigations. 3: 284-289. DOI: 10.1002/Roi.2970030607 |
0.439 |
|
1994 |
Rainey WH, Sawetawan C, Shay JW, Michael MD, Mathis JM, Kutteh W, Byrd W, Carr BR. Transformation of human granulosa cells with the E6 and E7 regions of human papillomavirus. The Journal of Clinical Endocrinology and Metabolism. 78: 705-10. PMID 8126145 DOI: 10.1210/Jcem.78.3.8126145 |
0.415 |
|
1994 |
Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW. Specific association of human telomerase activity with immortal cells and cancer. Science (New York, N.Y.). 266: 2011-5. PMID 7605428 DOI: 10.1126/Science.7605428 |
0.469 |
|
1994 |
Zhang W, Guo X, Hu G, Liu W, Shay J, Deisseroth A. A temperature-sensitive mutant of human p53. The Embo Journal. 13: 2535-2544. DOI: 10.1002/J.1460-2075.1994.Tb06543.X |
0.309 |
|
1993 |
Shay JW, Wright WE, Werbin H. Toward a molecular understanding of human breast cancer: A hypothesis Breast Cancer Research and Treatment. 25: 83-94. PMID 8518411 DOI: 10.1007/Bf00662404 |
0.41 |
|
1993 |
Haegen BAVd, Shay JW. Immortalization of human mammary epithelial cells by SV40 large T-antigen involves a two step mechanism. In Vitro Cellular & Developmental Biology – Animal. 29: 180-182. PMID 8463179 DOI: 10.1007/Bf02634177 |
0.357 |
|
1993 |
Shay JW, Van Der Haegen BA, Ying Y, Wright WE. The frequency of immortalization of human fibroblasts and mammary epithelial cells transfected with SV40 large T-antigen. Experimental Cell Research. 209: 45-52. PMID 8224005 DOI: 10.1006/Excr.1993.1283 |
0.394 |
|
1992 |
Funk WD, Pak DT, Karas RH, Wright WE, Shay JW. A transcriptionally active DNA-binding site for human p53 protein complexes. Molecular and Cellular Biology. 12: 2866-71. PMID 1588974 DOI: 10.1128/mcb.12.6.2866-2871.1992 |
0.3 |
|
1992 |
Wright WE, Shay JW. Telomere positional effects and the regulation of cellular senescence Trends in Genetics. 8: 193-197. PMID 1496553 DOI: 10.1016/0168-9525(92)90232-S |
0.433 |
|
1992 |
Shay JW, Werbin H, Funk WD, Wright WE. Cellular and molecular advances in elucidating p53 function Mutation Research/Reviews in Genetic Toxicology. 277: 163-171. PMID 1378532 DOI: 10.1016/0165-1110(92)90003-R |
0.309 |
|
1992 |
Savre-Train I, Piatyszek MA, Shay JW. Transcription of deleted mitochondrial DNA in human colon adenocarcinoma cells. Human Molecular Genetics. 1: 203-204. PMID 1339472 DOI: 10.1093/Hmg/1.3.203 |
0.365 |
|
1992 |
Shay JW, West MD, Wright WE. Re-expression of senescent markers in deinduced reversibly immortalized cells Experimental Gerontology. 27: 477-492. PMID 1330670 DOI: 10.1016/0531-5565(92)90003-I |
0.342 |
|
1991 |
Shay JW, Wright WE, Werbin H. Defining the molecular mechanisms of human cell immortalization Bba - Reviews On Cancer. 1072: 1-7. PMID 1850299 DOI: 10.1016/0304-419X(91)90003-4 |
0.45 |
|
1991 |
Ning Y, Shay JW, Lovell M, Taylor L, Ledbetter DH, Pereira-Smith OM. Tumor suppression by chromosome 11 is not due to cellular senescence. Experimental Cell Research. 192: 220-6. PMID 1670600 DOI: 10.1016/0014-4827(91)90179-X |
0.448 |
|
1991 |
Shay JW, Pereira-Smith OM, Wright WE. A role for both RB and p53 in the regulation of human cellular senescence Experimental Cell Research. 196: 33-39. PMID 1652450 DOI: 10.1016/0014-4827(91)90453-2 |
0.323 |
|
1990 |
Kamimura N, Ishii S, Ma LD, Shay JW. Three separate mitochondrial DNA sequences are contiguous in human genomic DNA. Journal of Molecular Biology. 210: 703-7. PMID 2614844 DOI: 10.1016/0022-2836(89)90103-4 |
0.344 |
|
1990 |
Duigou GJ, Babiss LE, Iman DS, Shay JW, Fisher PB. Suppression of the progression phenotype in somatic cell hybrids occurs in the absence of altered adenovirus type 5 gene expression. Molecular and Cellular Biology. 10: 2027-34. PMID 2139170 DOI: 10.1128/Mcb.10.5.2027 |
0.378 |
|
1989 |
Wright WE, Pereira-Smith OM, Shay JW. Reversible cellular senescence: Implications for immortalization of normal human diploid fibroblasts Molecular and Cellular Biology. 9: 3088-3092. PMID 2779554 DOI: 10.1128/Mcb.9.7.3088 |
0.377 |
|
1989 |
Shay JW, Wright WE. Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen Experimental Cell Research. 184: 109-118. PMID 2551703 DOI: 10.1016/0014-4827(89)90369-8 |
0.335 |
|
1989 |
Miranda AF, Ishii S, DiMauro S, Shay JW. Cytochrome c oxidase deficiency in Leigh's syndrome: genetic evidence for a nuclear DNA-encoded mutation. Neurology. 39: 697-702. PMID 2540452 DOI: 10.1212/Wnl.39.5.697 |
0.356 |
|
1988 |
Shay JW, Yinong L, Werbin H. Cytoplasmic suppression of tumor progression in reconstituted cells Somatic Cell and Molecular Genetics. 14: 345-350. PMID 3399962 DOI: 10.1007/Bf01534642 |
0.346 |
|
1987 |
Hayashi J, Yonekawa H, Murakami J, Tagashira Y, Pereira-Smith OM, Shay JW. Mitochondrial genomes in intraspecies mammalian cell hybrids display codominant or dominant/recessive behavior. Experimental Cell Research. 172: 218-27. PMID 3653255 DOI: 10.1016/0014-4827(87)90108-X |
0.361 |
|
1987 |
Shay JW. Cell enucleation, cybrids, reconstituted cells, and nuclear hybrids. Methods in Enzymology. 151: 221-237. PMID 3501528 DOI: 10.1016/S0076-6879(87)51020-5 |
0.387 |
|
1987 |
Walker C, Matthews AM, Shay JW. Suppression of Tumorigenicity Mediated by 5-Azacytidine and Associated With Increased Chromosome Number Journal of the National Cancer Institute. 78: 695-700. DOI: 10.1093/Jnci/78.4.695 |
0.379 |
|
1985 |
Rainey WE, Kramer RE, Mason JI, Shay JW. The effects of taxol, a microtubule‐stabilizing drug, on steroidogenic cells Journal of Cellular Physiology. 123: 17-24. PMID 2857725 DOI: 10.1002/Jcp.1041230104 |
0.36 |
|
1984 |
Walker C, Ranney DF, Shay JW. 5-azacytidine-lnduced uncoupling of differentiation and tumorigenicity in a murine cell line Journal of the National Cancer Institute. 73: 877-885. PMID 6207331 DOI: 10.1093/Jnci/73.4.877 |
0.381 |
|
1984 |
Walker C, Shay JW. 5-Azacytidine induced myogenesis in a differentiation defective cell line. Differentiation; Research in Biological Diversity. 25: 259-63. PMID 6199248 DOI: 10.1111/J.1432-0436.1984.Tb01364.X |
0.343 |
|
1983 |
Rainey WE, Hornsby PJ, Shay JW. Morphological correlates of adrenocorticotropin-stimulated steroidogenesis in cultured adrenocortical cells: Differences between bovine and human adrenal cells Endocrinology. 113: 48-54. PMID 6305639 DOI: 10.1210/Endo-113-1-48 |
0.392 |
|
1983 |
Cuthbert JA, Shay JW. Microtubules and lymphocyte responses: effect of colchicine and taxol on mitogen-induced human lymphocyte activation and proliferation. Journal of Cellular Physiology. 116: 127-34. PMID 6134740 DOI: 10.1002/Jcp.1041160202 |
0.377 |
|
1983 |
Crenshaw AH, Shay JW, Murrell LR. Micronucleation of human somatic cells with colcemid Journal of Tissue Culture Methods. 8: 185-187. DOI: 10.1007/Bf01665884 |
0.362 |
|
1982 |
Weide LG, Clark MA, Rupert CS, Shay JW. Detrimental effect of mitochondria on hybrid cell survival Somatic Cell Genetics. 8: 15-21. PMID 7101102 DOI: 10.1007/Bf01538647 |
0.335 |
|
1982 |
Clark MA, Shay JW. Long-lived cytoplasmic factors that suppress adrenal steroidogenesis Proceedings of the National Academy of Sciences of the United States of America. 79: 1144-1148. PMID 6280168 DOI: 10.1073/Pnas.79.4.1144 |
0.348 |
|
1981 |
Crenshaw AH, Shay JW, Murrell LR. Colcemid-induced micronucleation in cultured human cells. Journal of Ultrastructure Research. 75: 179-86. PMID 7265354 DOI: 10.1016/S0022-5320(81)80133-5 |
0.432 |
|
1981 |
Shay JW, Lorkowski G, Clark MA. Suppression of tumorigenicity in cybrids Journal of Supramolecular and Cellular Biochemistry. 16: 75-82. PMID 7029000 DOI: 10.1002/Jsscb.1981.380160107 |
0.36 |
|
1981 |
Clark MA, Shay JW. The role of tubulin in the steroidogenic response of murine adrenal and rat leydig cells Endocrinology. 109: 2261-2263. PMID 6273135 DOI: 10.1210/Endo-109-6-2261 |
0.32 |
|
1980 |
Clark MA, Shay JW, Goldstein L. Techniques for purifying L-cell karyoplasts with minimal amounts of cytoplasm Somatic Cell Genetics. 6: 455-464. PMID 7444714 DOI: 10.1007/Bf01539149 |
0.347 |
|
1980 |
Shay JW, Clark MA. Alternative method for identifying reconstituted cells Proceedings of the National Academy of Sciences of the United States of America. 77: 381-384. PMID 6244555 DOI: 10.1073/Pnas.77.1.381 |
0.397 |
|
1980 |
Crenshaw AH, Shay JW, Murrell LR. Mass enucleation of tissue culture cell monolayers Journal of Tissue Culture Methods. 6: 127-130. DOI: 10.1007/Bf02082864 |
0.336 |
|
1979 |
Shay JW, Clark MA. Nuclear control of tumorigenicity in cells reconstructed by PEG-induced fusion of cell fragments Journal of Supramolecular Structure. 11: 33-49. PMID 522482 DOI: 10.1002/Jss.400110105 |
0.404 |
|
1978 |
Shay JW, Peters TT, Fuseler JW. Cytoplasmic transfer of microtubule organizing centers in mouse tissue culture cells. Cell. 14: 835-42. PMID 688396 DOI: 10.1016/0092-8674(78)90339-2 |
0.379 |
|
1978 |
Nath K, Shay JW, Bollon AP. Relationship between dibutyryl cyclic AMP and microtubule organization in contracting heart muscle cells. Proceedings of the National Academy of Sciences of the United States of America. 75: 319-23. PMID 203935 DOI: 10.1073/Pnas.75.1.319 |
0.324 |
|
1977 |
Shay JW, Porter KR, Krueger TC. Motile behavior and topography of whole and enucleate mammalian cells on modified substrates Experimental Cell Research. 105: 1-8. PMID 837989 DOI: 10.1016/0014-4827(77)90146-X |
0.351 |
|
1977 |
Shay JW, Clark MA. Morphological studies on the enucleation of colchicine-treated L-929 cells Journal of Ultrasructure Research. 58: 155-161. PMID 583647 DOI: 10.1016/S0022-5320(77)90027-2 |
0.368 |
|
1977 |
Shay JW. Selection of reconstituted cells from karyoplasts fused to chloramphenicol-resistant cytoplasts. Proceedings of the National Academy of Sciences of the United States of America. 74: 2461-4. PMID 329286 DOI: 10.1073/Pnas.74.6.2461 |
0.361 |
|
1975 |
Shay JW, Gershenbaum MR, Porter KR. Enucleation of CHO cells by means of cytochalasin B and centrifugation: The topography of enucleation Experimental Cell Research. 94: 47-55. PMID 1193127 DOI: 10.1016/0014-4827(75)90529-7 |
0.339 |
|
1970 |
Rash JE, Shay JW, Biesele JJ. Cilia in cardiac differentiation. Journal of Ultrastructure Research. 29: 470-84. PMID 5365371 DOI: 10.1016/S0022-5320(69)90067-7 |
0.359 |
|
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