Year |
Citation |
Score |
2023 |
Alexander KK, Naaldijk Y, Fasiczka R, Brahmia B, Chen T, Hilfiker S, Kennedy EJ. Targeting Rab-RILPL interactions as a strategy to downregulate pathogenic LRRK2 in Parkinson's disease. Journal of Peptide Science : An Official Publication of the European Peptide Society. e3563. PMID 38135900 DOI: 10.1002/psc.3563 |
0.488 |
|
2023 |
Pathak P, Alexander KK, Helton LG, Kentros M, LeClair TJ, Zhang X, Ho FY, Moore TT, Hall S, Guaitoli G, Gloeckner CJ, Kortholt A, Rideout H, Kennedy EJ. Doubly Constrained C-terminal of Roc (COR) Domain-Derived Peptides Inhibit Leucine-Rich Repeat Kinase 2 (LRRK2) Dimerization. Acs Chemical Neuroscience. PMID 37200505 DOI: 10.1021/acschemneuro.3c00259 |
0.49 |
|
2022 |
Limaye AJ, Whittaker MK, Bendzunas GN, Cowell JK, Kennedy EJ. Targeting the WASF3 Complex to Suppress Metastasis. Pharmacological Research. 106302. PMID 35691539 DOI: 10.1016/j.phrs.2022.106302 |
0.766 |
|
2022 |
Limaye AJ, Bendzunas GN, Whittaker MK, LeClair TJ, Helton LG, Kennedy EJ. Optimized Stapled Peptides Targeting WASF3 in Breast Cancer. Acs Medicinal Chemistry Letters. 13: 570-576. PMID 35450347 DOI: 10.1021/acsmedchemlett.1c00627 |
0.753 |
|
2022 |
Byrne DP, Omar MH, Kennedy EJ, Eyers PA, Scott JD. Biochemical Analysis of AKAP-Anchored PKA Signaling Complexes. Methods in Molecular Biology (Clifton, N.J.). 2483: 297-317. PMID 35286684 DOI: 10.1007/978-1-0716-2245-2_19 |
0.452 |
|
2022 |
Singh RK, Soliman A, Guaitoli G, Störmer E, von Zweydorf F, Dal Maso T, Oun A, Van Rillaer L, Schmidt SH, Chatterjee D, David JA, Pardon E, Schwartz TU, Knapp S, Kennedy EJ, et al. Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35217606 DOI: 10.1073/pnas.2112712119 |
0.405 |
|
2021 |
Helton LG, Soliman A, von Zweydorf F, Kentros M, Manschwetus JT, Hall S, Gilsbach B, Ho FY, Athanasopoulos PS, Singh RK, LeClair TJ, Versées W, Raimondi F, Herberg FW, Gloeckner CJ, ... ... Kennedy EJ, et al. Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides. Acs Chemical Biology. PMID 34496561 DOI: 10.1021/acschembio.1c00487 |
0.4 |
|
2021 |
Limaye AJ, Bendzunas GN, Kennedy EJ. Targeted disruption of PKC from AKAP signaling complexes. Rsc Chemical Biology. 2: 1227-1231. PMID 34458835 DOI: 10.1039/d1cb00106j |
0.812 |
|
2021 |
Lasonder E, More K, Singh S, Haidar M, Bertinetti D, Kennedy EJ, Herberg FW, Holder AA, Langsley G, Chitnis CE. cAMP-Dependent Signaling Pathways as Potential Targets for Inhibition of Blood Stages. Frontiers in Microbiology. 12: 684005. PMID 34108954 DOI: 10.3389/fmicb.2021.684005 |
0.433 |
|
2021 |
Baffi TR, Lordén G, Wozniak JM, Feichtner A, Yeung W, Kornev AP, King CC, Del Rio JC, Limaye AJ, Bogomolovas J, Gould CM, Chen J, Kennedy EJ, Kannan N, Gonzalez DJ, et al. mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif. Science Signaling. 14. PMID 33850054 DOI: 10.1126/scisignal.abe4509 |
0.789 |
|
2020 |
Helton LG, Kennedy EJ. Targeting Plasmodium with constrained peptides and peptidomimetics. Iubmb Life. PMID 32037730 DOI: 10.1002/Iub.2244 |
0.441 |
|
2019 |
Manschwetus JT, Bendzunas GN, Limaye AJ, Knape MJ, Herberg FW, Kennedy EJ. A Stapled Peptide Mimic of the Pseudosubstrate Inhibitor PKI Inhibits Protein Kinase A. Molecules (Basel, Switzerland). 24. PMID 31009996 DOI: 10.3390/Molecules24081567 |
0.807 |
|
2019 |
Cao Z, Singh B, Li C, Markham NO, Carrington LJ, Franklin JL, Graves-Deal R, Kennedy EJ, Goldenring JR, Coffey RJ. PKA-mediated phosphorylation of NKD2 stimulates cell-surface delivery of TGF-α for EGFR transactivation. Traffic (Copenhagen, Denmark). PMID 30941853 DOI: 10.1111/Tra.12642 |
0.477 |
|
2019 |
Flaherty B, Ho TG, Schmidt S, Herberg FW, Peterson D, Kennedy E. Targeted Inhibition of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 With A Constrained J Domain-Derived Disruptor Peptide. Acs Infectious Diseases. PMID 30746930 DOI: 10.1021/Acsinfecdis.8B00347 |
0.516 |
|
2018 |
Kennedy EJ. Constrained peptides and biological targets. Bioorganic & Medicinal Chemistry. 26: 1117. PMID 29519596 DOI: 10.1016/J.Bmc.2018.02.046 |
0.432 |
|
2018 |
Burgess SG, Mukherjee M, Sabir S, Joseph N, Gutiérrez-Caballero C, Richards MW, Huguenin-Dezot N, Chin JW, Kennedy EJ, Pfuhl M, Royle SJ, Gergely F, Bayliss R. Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix. The Embo Journal. PMID 29510984 DOI: 10.15252/Embj.201797902 |
0.445 |
|
2018 |
Bendzunas NG, Dörfler S, Autenrieth K, Bertinetti D, Machal EMF, Kennedy EJ, Herberg FW. Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2. Bioorganic & Medicinal Chemistry. PMID 29449124 DOI: 10.1016/J.Bmc.2018.02.001 |
0.56 |
|
2017 |
Haidar M, de Laté PL, Kennedy EJ, Langsley G. Cell penetrating peptides to dissect host-pathogen protein-protein interactions in Theileria-transformed leukocytes. Bioorganic & Medicinal Chemistry. PMID 28917447 DOI: 10.1016/J.Bmc.2017.08.056 |
0.534 |
|
2017 |
Fulton MD, Hanold LE, Ruan Z, Patel S, Beedle AM, Kannan N, Kennedy EJ. Conformationally constrained peptides target the allosteric kinase dimer interface and inhibit EGFR activation. Bioorganic & Medicinal Chemistry. PMID 28911855 DOI: 10.1016/J.Bmc.2017.08.051 |
0.82 |
|
2017 |
Cowell JK, Teng Y, Bendzunas NG, Ara R, Arbab AS, Kennedy EJ. Suppression of Breast Cancer Metastasis Using Stapled Peptides Targeting the WASF Regulatory Complex. Cancer Growth and Metastasis. 10: 1179064417713197. PMID 28680267 DOI: 10.1177/1179064417713197 |
0.353 |
|
2017 |
Mo GC, Ross B, Hertel F, Manna P, Yang X, Greenwald E, Booth C, Plummer AM, Tenner B, Chen Z, Wang Y, Kennedy EJ, Cole PA, Fleming KG, Palmer A, et al. Genetically encoded biosensors for visualizing live-cell biochemical activity at super-resolution. Nature Methods. PMID 28288122 DOI: 10.1038/Nmeth.4221 |
0.622 |
|
2017 |
Hanold LE, Fulton MD, Kennedy EJ. Targeting kinase signaling pathways with constrained peptide scaffolds. Pharmacology & Therapeutics. PMID 28185915 DOI: 10.1016/J.Pharmthera.2017.02.014 |
0.827 |
|
2017 |
Haidar M, Lombes A, Bouillaud F, Kennedy EJ, Langsley G. HK2 recruitment to phospho-BAD prevents its degradation promoting Warburg glycolysis by Theileria-transformed leukocytes. Acs Infectious Diseases. PMID 28086019 DOI: 10.1021/Acsinfecdis.6B00180 |
0.411 |
|
2016 |
Haidar M, Ramdani G, Kennedy EJ, Langsley G. PKA and Apicomplexan Parasite Diseases. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme. PMID 27875850 DOI: 10.1055/S-0042-121366 |
0.457 |
|
2016 |
Haidar M, Ramdani G, Kennedy EJ, Langsley G. PKA and Apicomplexan Parasite Diseases. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme. PMID 27835919 DOI: 10.1055/s-0042-118459 |
0.352 |
|
2016 |
Mohanty S, Oruganty K, Kwon A, Byrne DP, Ferries S, Ruan Z, Hanold LE, Katiyar S, Kennedy EJ, Eyers PA, Kannan N. Correction: Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization. Plos Genetics. 12: e1006265. PMID 27513745 DOI: 10.1371/journal.pgen.1006265 |
0.749 |
|
2016 |
Teng Y, Qin H, Bahssan A, Bendzunas G, Kennedy EJ, Cowell J. The WASF3-NCKAP1-CYFIP1 complex is essential for breast cancer metastasis. Cancer Research. PMID 27432794 DOI: 10.1158/0008-5472.Can-16-0562 |
0.412 |
|
2016 |
Götz F, Roske Y, Schulz MS, Autenrieth K, Bertinetti D, Faelber K, Zühlke K, Kreuchwig A, Kennedy E, Krause G, Daumke O, Herberg FW, Heinemann U, Klussmann E. AKAP18:PKA-RIIα structure reveals crucial anchor points for recognition of regulatory subunits of PKA. The Biochemical Journal. PMID 27102985 DOI: 10.1042/Bcj20160242 |
0.431 |
|
2016 |
Mohanty S, Oruganty K, Kwon A, Byrne DP, Ferries S, Ruan Z, Hanold LE, Katiyar S, Kennedy EJ, Eyers PA, Kannan N. Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization. Plos Genetics. 12: e1005885. PMID 26925779 DOI: 10.1371/Journal.Pgen.1005885 |
0.793 |
|
2016 |
Bavencoffe A, Li Y, Wu Z, Yang Q, Herrera J, Kennedy EJ, Walters ET, Dessauer CW. Persistent Electrical Activity in Primary Nociceptors after Spinal Cord Injury Is Maintained by Scaffolded Adenylyl Cyclase and Protein Kinase A and Is Associated with Altered Adenylyl Cyclase Regulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 1660-8. PMID 26843647 DOI: 10.1523/Jneurosci.0895-15.2016 |
0.366 |
|
2015 |
Teng Y, Bahassan A, Dong D, Hanold LE, Ren X, Kennedy EJ, Cowell J. Targeting the WASF3-CYFIP1 complex using stapled peptides suppresses cancer cell invasion. Cancer Research. PMID 26676744 DOI: 10.1158/0008-5472.Can-15-1680 |
0.793 |
|
2015 |
Autenrieth K, Bendzunas G, Bertinetti D, Herberg FW, Kennedy EJ. Defining A-Kinase Anchoring Protein (AKAP) Specificity for Protein Kinase A Subunit RI (PKA-RI). Chembiochem : a European Journal of Chemical Biology. PMID 26611881 DOI: 10.1002/Cbic.201500632 |
0.52 |
|
2015 |
Kennedy EJ, Kannan N. Dialing in EGFR Signaling. Chemistry & Biology. 22: 687-8. PMID 26091165 DOI: 10.1016/J.Chembiol.2015.06.001 |
0.417 |
|
2015 |
Flaherty BR, Wang Y, Trope EC, Ho TG, Muralidharan V, Kennedy EJ, Peterson DS. The Stapled AKAP Disruptor Peptide STAD-2 Displays Antimalarial Activity through a PKA-Independent Mechanism. Plos One. 10: e0129239. PMID 26010880 DOI: 10.1371/Journal.Pone.0129239 |
0.679 |
|
2015 |
Hermann JS, Skroblin P, Bertinetti D, Hanold LE, von der Heide EK, Wagener EM, Zenn HM, Klussmann E, Kennedy EJ, Herberg FW. Neurochondrin is an atypical RIIα-specific A-kinase anchoring protein. Biochimica Et Biophysica Acta. PMID 25916936 DOI: 10.1016/J.Bbapap.2015.04.018 |
0.805 |
|
2015 |
Mohanty S, Kennedy EJ, Herberg FW, Hui R, Taylor SS, Langsley G, Kannan N. Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design. Biochimica Et Biophysica Acta. PMID 25847873 DOI: 10.1016/J.Bbapap.2015.03.012 |
0.361 |
|
2015 |
Hanold LE, Watkins CP, Ton NT, Liaw P, Beedle AM, Kennedy EJ. Design of a selenylsulfide-bridged EGFR dimerization arm mimic. Bioorganic & Medicinal Chemistry. 23: 2761-6. PMID 25840798 DOI: 10.1016/J.Bmc.2015.03.040 |
0.787 |
|
2015 |
Hanold LE, Oruganty K, Ton NT, Beedle AM, Kannan N, Kennedy EJ. Inhibiting EGFR dimerization using triazolyl-bridged dimerization arm mimics. Plos One. 10: e0118796. PMID 25790232 DOI: 10.1371/Journal.Pone.0118796 |
0.786 |
|
2015 |
Kennedy EJ, Scott JD. Selective disruption of the AKAP signaling complexes. Methods in Molecular Biology (Clifton, N.J.). 1294: 137-50. PMID 25783883 DOI: 10.1007/978-1-4939-2537-7_11 |
0.583 |
|
2015 |
Wang Y, Ho TG, Franz E, Hermann JS, Smith FD, Hehnly H, Esseltine JL, Hanold LE, Murph MM, Bertinetti D, Scott JD, Herberg FW, Kennedy EJ. PKA-Type I Selective Constrained Peptide Disruptors of AKAP Complexes. Acs Chemical Biology. 10: 1502-10. PMID 25765284 DOI: 10.1021/Acschembio.5B00009 |
0.817 |
|
2014 |
Wang Y, Ho TG, Bertinetti D, Neddermann M, Franz E, Mo GC, Schendowich LP, Sukhu A, Spelts RC, Zhang J, Herberg FW, Kennedy EJ. Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides. Acs Chemical Biology. 9: 635-42. PMID 24422448 DOI: 10.1021/Cb400900R |
0.746 |
|
2014 |
Wang Y, Ho TG, Bertinetti D, Neddermann M, Franz E, Mo GCH, Schendowich LP, Sukhu A, Spelts RC, Zhang J, Herberg FW, Kennedy EJ. Correction to Isoform-Selective Disruption of AKAP-Localized PKA Using Hydrocarbon Stapled Peptides Acs Chemical Biology. 9: 1386-1386. DOI: 10.1021/Cb500329Z |
0.639 |
|
2009 |
Kennedy EJ, Yang J, Pillus L, Taylor SS, Ghosh G. Identifying critical non-catalytic residues that modulate protein kinase A activity. Plos One. 4: e4746. PMID 19270744 DOI: 10.1371/Journal.Pone.0004746 |
0.646 |
|
2009 |
Yang J, Kennedy EJ, Wu J, Deal MS, Pennypacker J, Ghosh G, Taylor SS. Contribution of non-catalytic core residues to activity and regulation in protein kinase A. The Journal of Biological Chemistry. 284: 6241-8. PMID 19122195 DOI: 10.1074/Jbc.M805862200 |
0.636 |
|
2008 |
Kennedy EJ, Ghosh G, Pillus L. Identification of functionally distinct regions that mediate biological activity of the protein kinase a homolog Tpk2. The Journal of Biological Chemistry. 283: 1084-93. PMID 17971450 DOI: 10.1074/Jbc.M704028200 |
0.66 |
|
2005 |
Kennedy EJ, Pillus L, Ghosh G. Pho5p and newly identified nucleotide pyrophosphatases/ phosphodiesterases regulate extracellular nucleotide phosphate metabolism in Saccharomyces cerevisiae. Eukaryotic Cell. 4: 1892-901. PMID 16278456 DOI: 10.1128/Ec.4.11.1892-1901.2005 |
0.531 |
|
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