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Chad N. Brocker, Ph.D. - Publications

Affiliations: 
2012 University of Colorado Anschutz Medical Campus, Denver, Aurora, CO 
Area:
Toxicology, Biochemistry
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34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Xie C, Takahashi S, Brocker CN, He S, Li C, Xie G, Jang K, Gao X, Krausz KW, Qu A, Levi M, Gonzalez FJ. Hepatocyte peroxisome proliferator-activated receptor alpha regulates bile acid synthesis and transport. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. PMID 31195146 DOI: 10.1016/J.Bbalip.2019.05.014  0.336
2019 Kim D, Brocker CN, Takahashi S, Yagai T, Kim T, Xie G, Wang H, Qu A, Gonzalez FJ. Keratin 23 is a PPARA-dependent, MYC-amplified oncogene that promotes hepatocyte proliferation. Hepatology (Baltimore, Md.). PMID 30697791 DOI: 10.1002/Hep.30530  0.347
2018 Xie G, Yin S, Zhang ZZ, Qi D, Wang X, Kim D, Yagai T, Brocker CN, Wang Y, Gonzalez FJ, Wang H, Qu A. Hepatocyte PPARα enhances liver regeneration after partial hepatectomy in mice. The American Journal of Pathology. PMID 30448405 DOI: 10.1016/J.Ajpath.2018.10.009  0.337
2018 Brocker CN, Patel DP, Velenosi TJ, Kim D, Yan T, Yue J, Li G, Krausz KW, Gonzalez FJ. Extrahepatic PPARα modulates fatty acid oxidation and attenuates fasting-induced hepatosteatosis in mice. Journal of Lipid Research. PMID 30158201 DOI: 10.1194/Jlr.M088419  0.379
2017 Li G, Brocker CN, Yan T, Xie C, Krausz KW, Xiang R, Gonzalez FJ. Metabolic adaptation to intermittent fasting is independent of peroxisome proliferator-activated receptor alpha. Molecular Metabolism. PMID 29146411 DOI: 10.1016/J.Molmet.2017.10.011  0.331
2017 Li G, Brocker CN, Xie C, Yan T, Noguchi A, Krausz KW, Xiang R, Gonzalez FJ. Hepatic PPARα mediates the major metabolic effects of Wy-14643. Journal of Gastroenterology and Hepatology. PMID 29141109 DOI: 10.1111/Jgh.14046  0.327
2017 Brocker CN, Yue J, Kim D, Qu A, Bonzo JA, Gonzalez FJ. Hepatocyte-specific PPARA expression exclusively promotes agonist-induced cell proliferation without influence from non-parenchymal cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. ajpgi.00205.2016. PMID 28082284 DOI: 10.1152/Ajpgi.00205.2016  0.358
2017 Gonzalez FJ, Xie C, Jiang C, Brocker C, Patterson AD. The role of toxic lipids metabolic disease Drug Metabolism and Pharmacokinetics. 32. DOI: 10.1016/J.Dmpk.2016.10.058  0.303
2016 Burdin DV, Kolobov AA, Brocker C, Soshnev AA, Samusik N, Demyanov AV, Brilloff S, Jarzebska N, Martens-Lobenhoffer J, Mieth M, Maas R, Bornstein SR, Bode-Böger SM, Gonzalez F, Weiss N, et al. Diabetes-linked transcription factor HNF4α regulates metabolism of endogenous methylarginines and β-aminoisobutyric acid by controlling expression of alanine-glyoxylate aminotransferase 2. Scientific Reports. 6: 35503. PMID 27752141 DOI: 10.1038/Srep35503  0.342
2016 Takahashi S, Fukami T, Masuo Y, Brocker CN, Xie C, Krausz KW, Wolf CR, Henderson CJ, Gonzalez FJ. Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans. Journal of Lipid Research. PMID 27638959 DOI: 10.1194/Jlr.M071183  0.35
2016 Yan T, Wang H, Zhao M, Yagai T, Chai Y, Krausz KW, Xie C, Cheng X, Zhang J, Che Y, Li F, Wu Y, Brocker CN, Gonzalez FJ, Wang G, et al. Glycyrrhizin protects against acetaminophen-induced acute liver injury via alleviating TNFα mediated apoptosis. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 26965985 DOI: 10.1124/Dmd.116.069419  0.307
2014 Monte AA, Brocker C, Nebert DW, Gonzalez FJ, Thompson DC, Vasiliou V. Improved drug therapy: triangulating phenomics with genomics and metabolomics. Human Genomics. 8: 16. PMID 25181945 DOI: 10.1186/S40246-014-0016-9  0.463
2014 Qi Y, Jiang C, Tanaka N, Krausz KW, Brocker CN, Fang ZZ, Bredell BX, Shah YM, Gonzalez FJ. PPARα-dependent exacerbation of experimental colitis by the hypolipidemic drug fenofibrate. American Journal of Physiology. Gastrointestinal and Liver Physiology. 307: G564-73. PMID 25035112 DOI: 10.1152/Ajpgi.00153.2014  0.371
2014 Babcock HE, Dutta S, Alur RP, Brocker C, Vasiliou V, Vitale S, Abu-Asab M, Brooks BP. aldh7a1 regulates eye and limb development in zebrafish. Plos One. 9: e101782. PMID 25004007 DOI: 10.1371/Journal.Pone.0101782  0.488
2014 Bonzo JA, Brocker C, Jiang C, Wang RH, Deng CX, Gonzalez FJ. Hepatic sirtuin 1 is dispensable for fibrate-induced peroxisome proliferator-activated receptor-α function in vivo. American Journal of Physiology. Endocrinology and Metabolism. 306: E824-37. PMID 24496310 DOI: 10.1152/Ajpendo.00175.2013  0.345
2014 Liu A, Krausz KW, Fang ZZ, Brocker C, Qu A, Gonzalez FJ. Gemfibrozil disrupts lysophosphatidylcholine and bile acid homeostasis via PPARα and its relevance to hepatotoxicity. Archives of Toxicology. 88: 983-96. PMID 24385052 DOI: 10.1007/S00204-013-1188-0  0.329
2013 Singh S, Brocker C, Koppaka V, Chen Y, Jackson BC, Matsumoto A, Thompson DC, Vasiliou V. Aldehyde dehydrogenases in cellular responses to oxidative/electrophilic stress. Free Radical Biology & Medicine. 56: 89-101. PMID 23195683 DOI: 10.1016/J.Freeradbiomed.2012.11.010  0.722
2013 Brocker C, Vasiliou M, Carpenter S, Carpenter C, Zhang Y, Wang X, Kotchoni SO, Wood AJ, Kirch HH, Kope?ný D, Nebert DW, Vasiliou V. Aldehyde dehydrogenase (ALDH) superfamily in plants: gene nomenclature and comparative genomics. Planta. 237: 189-210. PMID 23007552 DOI: 10.1007/S00425-012-1749-0  0.556
2012 Brocker C, Thompson DC, Vasiliou V. The role of hyperosmotic stress in inflammation and disease. Biomolecular Concepts. 3: 345-364. PMID 22977648 DOI: 10.1515/Bmc-2012-0001  0.553
2012 Zhang Y, Mao L, Wang H, Brocker C, Yin X, Vasiliou V, Fei Z, Wang X. Genome-wide identification and analysis of grape aldehyde dehydrogenase (ALDH) gene superfamily. Plos One. 7: e32153. PMID 22355416 DOI: 10.1371/Journal.Pone.0032153  0.56
2012 Gasparetto M, Sekulovic S, Brocker C, Tang P, Zakaryan A, Xiang P, Kuchenbauer F, Wen M, Kasaian K, Witty MF, Rosten P, Chen Y, Imren S, Duester G, Thompson DC, et al. Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development. Experimental Hematology. 40: 318-29.e2. PMID 22198153 DOI: 10.1016/J.Exphem.2011.12.006  0.544
2011 Jackson B, Brocker C, Thompson DC, Black W, Vasiliou K, Nebert DW, Vasiliou V. Update on the aldehyde dehydrogenase gene (ALDH) superfamily. Human Genomics. 5: 283-303. PMID 21712190 DOI: 10.1186/1479-7364-5-4-283  0.579
2011 Brocker C, Cantore M, Failli P, Vasiliou V. Aldehyde dehydrogenase 7A1 (ALDH7A1) attenuates reactive aldehyde and oxidative stress induced cytotoxicity. Chemico-Biological Interactions. 191: 269-77. PMID 21338592 DOI: 10.1016/J.Cbi.2011.02.016  0.622
2010 Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V. Evolutionary divergence and functions of the human interleukin (IL) gene family. Human Genomics. 5: 30-55. PMID 21106488 DOI: 10.1186/1479-7364-5-1-30  0.476
2010 Brocker C, Carpenter C, Nebert DW, Vasiliou V. Evolutionary divergence and functions of the human acyl-CoA thioesterase gene ( ACOT ) family. Human Genomics. 4: 411-20. PMID 20846931 DOI: 10.1186/1479-7364-4-6-411  0.571
2010 Scharer G, Brocker C, Vasiliou V, Creadon-Swindell G, Gallagher RC, Spector E, Van Hove JL. The genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy due to mutations in ALDH7A1. Journal of Inherited Metabolic Disease. 33: 571-81. PMID 20814824 DOI: 10.1007/S10545-010-9187-2  0.468
2010 Marchitti SA, Orlicky DJ, Brocker C, Vasiliou V. Aldehyde dehydrogenase 3B1 (ALDH3B1): immunohistochemical tissue distribution and cellular-specific localization in normal and cancerous human tissues. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 58: 765-83. PMID 20729348 DOI: 10.1369/Jhc.2010.955773  0.725
2010 Marchitti SA, Brocker C, Orlicky DJ, Vasiliou V. Molecular characterization, expression analysis, and role of ALDH3B1 in the cellular protection against oxidative stress. Free Radical Biology & Medicine. 49: 1432-43. PMID 20699116 DOI: 10.1016/J.Freeradbiomed.2010.08.004  0.728
2010 Stagos D, Chen Y, Brocker C, Donald E, Jackson BC, Orlicky DJ, Thompson DC, Vasiliou V. Aldehyde dehydrogenase 1B1: molecular cloning and characterization of a novel mitochondrial acetaldehyde-metabolizing enzyme. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 1679-87. PMID 20616185 DOI: 10.1124/Dmd.110.034678  0.609
2010 Brocker C, Lassen N, Estey T, Pappa A, Cantore M, Orlova VV, Chavakis T, Kavanagh KL, Oppermann U, Vasiliou V. Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress. The Journal of Biological Chemistry. 285: 18452-63. PMID 20207735 DOI: 10.1074/Jbc.M109.077925  0.7
2010 Backos DS, Brocker CN, Franklin CC. Manipulation of cellular GSH biosynthetic capacity via TAT-mediated protein transduction of wild-type or a dominant-negative mutant of glutamate cysteine ligase alters cell sensitivity to oxidant-induced cytotoxicity. Toxicology and Applied Pharmacology. 243: 35-45. PMID 19914271 DOI: 10.1016/J.Taap.2009.11.010  0.367
2010 Brocker C, Carpenter C, Nebert DW, Vasiliou V. Evolutionary divergence and functions of the human acyl-CoA thioesterase gene (ACOT) family Human Genomics. DOI: 10.1186/1479-7364-4-6-411  0.527
2009 Brocker CN, Vasiliou V, Nebert DW. Evolutionary divergence and functions of the ADAM and ADAMTS gene families. Human Genomics. 4: 43-55. PMID 19951893 DOI: 10.1186/1479-7364-4-1-43  0.545
2008 Marchitti SA, Brocker C, Stagos D, Vasiliou V. Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily. Expert Opinion On Drug Metabolism & Toxicology. 4: 697-720. PMID 18611112 DOI: 10.1517/17425255.4.6.697  0.718
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