Idit Shachar - Publications

Affiliations: 
Weizmann Institute of Science, Rehovot, Israel 
Area:
Cell Biology, Biochemistry

82 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Lewinsky H, Gunes EG, David K, Radomir L, Kramer MP, Pellegrino B, Perpinial M, Chen J, He TF, Mansour AG, Teng KY, Bhattacharya S, Caserta E, Troadec E, Lee P, ... ... Shachar I, et al. CD84 is a regulator of the immunosuppressive microenvironment in multiple myeloma. Jci Insight. 8. PMID 37485873 DOI: 10.1172/jci.insight.173312  0.321
2022 David K, Friedlander G, Pellegrino B, Radomir L, Lewinsky H, Leng L, Bucala R, Becker-Herman S, Shachar I. CD74 as a regulator of transcription in normal B cells. Cell Reports. 41: 111572. PMID 36323260 DOI: 10.1016/j.celrep.2022.111572  0.459
2022 Thavayogarajah T, Sinitski D, Bounkari OE, Torres-Garcia L, Lewinsky H, Harjung A, Chen HR, Panse J, Vankann L, Shachar I, Bernhagen J, Koschmieder S. CXCR4 and CD74 together enhance cell survival in response to MIF in CLL. Experimental Hematology. PMID 36096455 DOI: 10.1016/j.exphem.2022.08.005  0.525
2021 Becker-Herman S, Rozenberg M, Hillel-Karniel C, Gil-Yarom N, Kramer M, Barak A, Sever L, David K, Radomir L, Lewinsky H, Levi M, Friedlander G, Bucala R, Peled A, Shachar I. CD74 is a regulator of hematopoietic stem cell maintenance. Plos Biology. 19: e3001121. PMID 33661886 DOI: 10.1371/journal.pbio.3001121  0.434
2021 Lewinsky H, Gunes EG, David K, Radomir L, Kramer MP, Pellegrino B, Perpinial M, Chen J, He TF, Mansour A, Teng KY, Bhattacharya S, Caserta E, Troadec E, Lee PP, ... ... Shachar I, et al. CD84 is a regulator of the immunosuppressive microenvironment in Multiple Myeloma. Jci Insight. PMID 33465053 DOI: 10.1172/jci.insight.141683  0.502
2020 Slobodin B, Bahat A, Sehrawat U, Becker-Herman S, Zuckerman B, Weiss AN, Han R, Elkon R, Agami R, Ulitsky I, Shachar I, Dikstein R. Transcription Dynamics Regulate Poly(A) Tails and Expression of the RNA Degradation Machinery to Balance mRNA Levels. Molecular Cell. PMID 32294471 DOI: 10.1016/J.Molcel.2020.03.022  0.325
2020 Eisenberg-Lerner A, Benyair R, Hizkiahou N, Nudel N, Maor R, Kramer MP, Shmueli MD, Zigdon I, Cherniavsky Lev M, Ulman A, Sagiv JY, Dayan M, Dassa B, Rosenwald M, Shachar I, et al. Golgi organization is regulated by proteasomal degradation. Nature Communications. 11: 409. PMID 31964869 DOI: 10.1038/S41467-019-14038-9  0.32
2019 Barak AF, Lewinsky H, Perpinial M, Huber V, Radomir L, Kramer MP, Sever L, Wolf Y, Shapiro M, Herishanu Y, Jung S, Becker-Herman S, Shachar I. Bone marrow dendritic cells support the survival of chronic lymphocytic leukemia cells in a CD84 dependent manner. Oncogene. PMID 31772329 DOI: 10.1038/S41388-019-1121-Y  0.582
2019 Kaushansky N, Bakos E, Becker-Herman S, Shachar I, Ben-Nun A. Circulating Picomolar Levels of CCL2 Downregulate Ongoing Chronic Experimental Autoimmune Encephalomyelitis by Induction of Regulatory Mechanisms. Journal of Immunology (Baltimore, Md. : 1950). PMID 31484731 DOI: 10.4049/Jimmunol.1900424  0.457
2019 Sever L, Radomir L, Strim K, Weiner A, Shchottlender N, Lewinsky H, Barak AF, Friedlander G, Ben-Dor S, Becker-Herman S, Shachar I. SLAMF9 regulates pDC homeostasis and function in health and disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 31346085 DOI: 10.1073/Pnas.1900079116  0.442
2019 Gunes EG, Lewinsky H, Viola D, Caserta E, Rosenzweig M, Htut M, Sanchez J, Buettner R, Marcucci G, Keats J, Pichiorri F, Shachar I, Rosen S. CD84: A Potential Novel Therapeutic Target in the Multiple Myeloma Microenvironment Clinical Lymphoma Myeloma and Leukemia. 19: e148-e149. DOI: 10.1016/J.Clml.2019.09.247  0.373
2018 Shachar I, Barak A, Lewinsky H, Sever L, Radomir L. SLAMF receptors on normal and malignant B cells. Clinical Immunology (Orlando, Fla.). PMID 30448442 DOI: 10.1016/J.Clim.2018.10.020  0.577
2018 Lewinsky H, Barak AF, Huber V, Kramer MP, Radomir L, Sever L, Orr I, Mirkin V, Dezorella N, Shapiro M, Cohen Y, Shvidel L, Seiffert M, Herishanu Y, Becker-Herman S, ... Shachar I, et al. CD84 regulates PD-1/PD-L1 expression and function in chronic lymphocytic leukemia. The Journal of Clinical Investigation. PMID 30277471 DOI: 10.1172/Jci96610  0.54
2018 Klasen C, Ziehm T, Huber M, Asare Y, Kapurniotu A, Shachar I, Bernhagen J, El Bounkari O. LPS-mediated cell surface expression of CD74 promotes the proliferation of B cells in response to MIF. Cellular Signalling. PMID 29476963 DOI: 10.1016/J.Cellsig.2018.02.010  0.593
2018 Gunes EG, Lewinsky H, Viola D, Caserta E, Rosenzweig M, Htut M, Sanchez JF, Buettner R, Marcucci G, Keats JJ, Krishnan A, Rosen ST, Shachar I, Pichiorri F. CD84: A Potential Novel Therapeutic Target in Multiple Myeloma Blood. 132: 1924-1924. DOI: 10.1182/Blood-2018-99-119655  0.49
2017 Radomir L, Cohen S, Kramer MP, Bakos E, Lewinsky H, Barak A, Porat Z, Bucala R, Stepensky P, Becker-Herman S, Shachar I. T Cells Regulate Peripheral Naive Mature B Cell Survival by Cell-Cell Contact Mediated through SLAMF6 and SAP. Journal of Immunology (Baltimore, Md. : 1950). PMID 28904129 DOI: 10.4049/Jimmunol.1700557  0.651
2017 Bakos E, Thaiss CA, Kramer MP, Cohen S, Radomir L, Orr I, Kaushansky N, Ben-Nun A, Becker-Herman S, Shachar I. CCR2 Regulates the Immune Response by Modulating the Interconversion and Function of Effector and Regulatory T Cells. Journal of Immunology (Baltimore, Md. : 1950). PMID 28507030 DOI: 10.4049/Jimmunol.1601458  0.475
2017 Haran M, Mirkin V, Braester A, Harpaz N, Shevetz O, Shtreiter M, Greenberg S, Mordich O, Amram O, Binsky-Ehrenreich I, Marom A, Shachar I, Herishanu Y, Ruchlemer R, Berrebi A, et al. A phase I-II clinical trial of the anti-CD74 monoclonal antibody milatuzumab in frail patients with refractory chronic lymphocytic leukaemia: A patient based approach. British Journal of Haematology. PMID 28466956 DOI: 10.1111/Bjh.14726  0.316
2017 Wakim J, Arman E, Becker-Herman S, Kramer MP, Bakos E, Shachar I, Elson A. The PTPROt tyrosine phosphatase functions as an obligate haploinsufficient tumor suppressor in vivo in B-cell chronic lymphocytic leukemia. Oncogene. 36: 3686-3694. PMID 28166196 DOI: 10.1038/Onc.2016.523  0.483
2016 Gil-Yarom N, Radomir L, Sever L, Kramer MP, Lewinsky H, Bornstein C, Blecher-Gonen R, Barnett-Itzhaki Z, Mirkin V, Friedlander G, Shvidel L, Herishanu Y, Lolis EJ, Becker-Herman S, Amit I, ... Shachar I, et al. CD74 is a novel transcription regulator. Proceedings of the National Academy of Sciences of the United States of America. PMID 28031488 DOI: 10.1073/Pnas.1612195114  0.57
2016 Marom A, Barak AF, Kramer MP, Lewinsky H, Binsky-Ehrenreich I, Cohen S, Tsitsou-Kampeli A, Kalchenko V, Kuznetsov Y, Mirkin V, Dezorella N, Shapiro M, Schwartzberg PL, Cohen Y, Shvidel L, ... ... Shachar I, et al. CD84 mediates CLL-microenvironment interactions. Oncogene. PMID 27452524 DOI: 10.1038/Onc.2016.238  0.592
2016 Weiss JM, Robinet M, Aricha R, Cufi P, Villeret B, Lantner F, Shachar I, Fuchs S, Souroujon MC, Berrih-Aknin S, Le Panse R. Novel CXCL13 transgenic mouse: inflammation drives pathogenic effect of CXCL13 in experimental myasthenia gravis. Oncotarget. PMID 26771137 DOI: 10.18632/Oncotarget.6885  0.509
2015 Zelman-Toister E, Bakos E, Cohen S, Zigmond E, Shezen E, Grabovsky V, Sagiv A, Hart G, Kaushansky N, Ben-Nun A, Maharshak N, Sonnenberg A, Alon R, Becker-Herman S, Shachar I. CD151 Regulates T-Cell Migration in Health and Inflammatory Bowel Disease. Inflammatory Bowel Diseases. PMID 26529559 DOI: 10.1097/Mib.0000000000000621  0.791
2014 Bucala R, Shachar I. The integral role of CD74 in antigen presentation, MIF signal transduction, and B cell survival and homeostasis. Mini Reviews in Medicinal Chemistry. 14: 1132-8. PMID 25643611 DOI: 10.2174/1389557515666150203144111  0.547
2014 Klasen C, Ohl K, Sternkopf M, Shachar I, Schmitz C, Heussen N, Hobeika E, Levit-Zerdoun E, Tenbrock K, Reth M, Bernhagen J, El Bounkari O. MIF promotes B cell chemotaxis through the receptors CXCR4 and CD74 and ZAP-70 signaling. Journal of Immunology (Baltimore, Md. : 1950). 192: 5273-84. PMID 24760155 DOI: 10.4049/Jimmunol.1302209  0.666
2014 Cohen S, Shachar I. Midkine as a regulator of B cell survival in health and disease. British Journal of Pharmacology. 171: 888-95. PMID 24111754 DOI: 10.1111/Bph.12419  0.548
2014 Binsky-Ehrenreich I, Marom A, Sobotta MC, Shvidel L, Berrebi A, Hazan-Halevy I, Kay S, Aloshin A, Sagi I, Goldenberg DM, Leng L, Bucala R, Herishanu Y, Haran M, Shachar I. CD84 is a survival receptor for CLL cells Oncogene. 33: 1006-1016. PMID 23435417 DOI: 10.1038/Onc.2013.31  0.568
2013 Stepensky P, Keller B, Buchta M, Kienzler AK, Elpeleg O, Somech R, Cohen S, Shachar I, Miosge LA, Schlesier M, Fuchs I, Enders A, Eibel H, Grimbacher B, Warnatz K. Deficiency of caspase recruitment domain family, member 11 (CARD11), causes profound combined immunodeficiency in human subjects. The Journal of Allergy and Clinical Immunology. 131: 477-85.e1. PMID 23374270 DOI: 10.1016/J.Jaci.2012.11.050  0.352
2013 Shachar I, Karin N. The dual roles of inflammatory cytokines and chemokines in the regulation of autoimmune diseases and their clinical implications. Journal of Leukocyte Biology. 93: 51-61. PMID 22949334 DOI: 10.1189/Jlb.0612293  0.404
2012 Shachar I, Cohen S, Marom A, Becker-Herman S. Regulation of CLL survival by hypoxia-inducible factor and its target genes. Febs Letters. 586: 2906-10. PMID 22841548 DOI: 10.1016/J.Febslet.2012.07.016  0.449
2012 Cohen S, Shachar I. Cytokines as regulators of proliferation and survival of healthy and malignant peripheral B cells. Cytokine. 60: 13-22. PMID 22784632 DOI: 10.1016/J.Cyto.2012.06.019  0.603
2012 Cohen S, Shoshana OY, Zelman-Toister E, Maharshak N, Binsky-Ehrenreich I, Gordin M, Hazan-Halevy I, Herishanu Y, Shvidel L, Haran M, Leng L, Bucala R, Harroch S, Shachar I. The cytokine midkine and its receptor RPTPζ regulate B cell survival in a pathway induced by CD74. Journal of Immunology (Baltimore, Md. : 1950). 188: 259-69. PMID 22140262 DOI: 10.4049/Jimmunol.1101468  0.826
2011 Shachar I, Haran M. The secret second life of an innocent chaperone: the story of CD74 and B cell/chronic lymphocytic leukemia cell survival. Leukemia & Lymphoma. 52: 1446-54. PMID 21417823 DOI: 10.3109/10428194.2011.565437  0.584
2011 Lapter S, Ben-David H, Sharabi A, Zinger H, Telerman A, Gordin M, Leng L, Bucala R, Shachar I, Mozes E. A role for the B-cell CD74/macrophage migration inhibitory factor pathway in the immunomodulation of systemic lupus erythematosus by a therapeutic tolerogenic peptide. Immunology. 132: 87-95. PMID 20738420 DOI: 10.1111/J.1365-2567.2010.03342.X  0.577
2011 Binsky-Ehrenreich I, Marom A, Sobota M, Lantner F, Harpaz N, Haran M, Herishanu Y, Shachar I. 2.1 CD84 is a Survival Receptor for CLL Cells Clinical Lymphoma Myeloma and Leukemia. 11: S160. DOI: 10.1016/J.Clml.2011.09.034  0.511
2011 Cohen S, Shoshana O, Zelman-Toister E, Maharshak N, Binsky- Ehrenreich I, Gordin M, Shvidel L, Haran M, Leng L, Bucala R, Harroch S, Shachar I. 1.23 The Cytokine Midkine and its Receptor Tyrosine Phosphatase Zeta Regulate B Cell Survival in Health and Disease in a Pathway Induced by CD74 Clinical Lymphoma Myeloma and Leukemia. 11: S156. DOI: 10.1016/J.Clml.2011.09.024  0.794
2010 Manevich-Mendelson E, Grabovsky V, Feigelson SW, Cinamon G, Gore Y, Goverse G, Monkley SJ, Margalit R, Melamed D, Mebius RE, Critchley DR, Shachar I, Alon R. Talin1 is required for integrin-dependent B lymphocyte homing to lymph nodes and the bone marrow but not for follicular B-cell maturation in the spleen. Blood. 116: 5907-18. PMID 20923969 DOI: 10.1182/Blood-2010-06-293506  0.843
2010 Gordin M, Tesio M, Cohen S, Gore Y, Lantner F, Leng L, Bucala R, Shachar I. c-Met and its ligand hepatocyte growth factor/scatter factor regulate mature B cell survival in a pathway induced by CD74. Journal of Immunology (Baltimore, Md. : 1950). 185: 2020-31. PMID 20639480 DOI: 10.4049/Jimmunol.0902566  0.849
2010 Maharshak N, Cohen S, Lantner F, Hart G, Leng L, Bucala R, Shachar I. CD74 is a survival receptor on colon epithelial cells. World Journal of Gastroenterology. 16: 3258-66. PMID 20614481 DOI: 10.3748/Wjg.V16.I26.3258  0.52
2010 Gore Y, Lantner F, Hart G, Shachar I. Mad3 negatively regulates B cell differentiation in the spleen by inducing Id2 expression. Molecular Biology of the Cell. 21: 1864-71. PMID 20375148 DOI: 10.1091/Mbc.E09-09-0813  0.839
2010 Binsky I, Lantner F, Grabovsky V, Harpaz N, Shvidel L, Berrebi A, Goldenberg DM, Leng L, Bucala R, Alon R, Haran M, Shachar I. TAp63 regulates VLA-4 expression and chronic lymphocytic leukemia cell migration to the bone marrow in a CD74-dependent manner. Journal of Immunology (Baltimore, Md. : 1950). 184: 4761-9. PMID 20357260 DOI: 10.4049/Jimmunol.0904149  0.57
2010 Maharshak N, Hart G, Ron E, Zelman E, Sagiv A, Arber N, Brazowski E, Margalit R, Elinav E, Shachar I. CCL2 (pM levels) as a therapeutic agent in inflammatory bowel disease models in mice Inflammatory Bowel Diseases. 16: 1496-1504. PMID 20222120 DOI: 10.1002/Ibd.21254  0.361
2009 Berrih-Aknin S, Ruhlmann N, Bismuth J, Cizeron-Clairac G, Zelman E, Shachar I, Dartevelle P, de Rosbo NK, Le Panse R. CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia. Annals of Neurology. 66: 521-31. PMID 19847900 DOI: 10.1002/Ana.21628  0.462
2009 Hartmann TN, Grabovsky V, Wang W, Desch P, Rubenzer G, Wollner S, Binsky I, Vallon-Eberhard A, Sapoznikov A, Burger M, Shachar I, Haran M, Honczarenko M, Greil R, Alon R. Circulating B-cell chronic lymphocytic leukemia cells display impaired migration to lymph nodes and bone marrow. Cancer Research. 69: 3121-30. PMID 19293181 DOI: 10.1158/0008-5472.Can-08-4136  0.561
2009 Maharshak N, Cohen S, Shachar I. S2047 CD74 Is a Novel Survival Receptor On Colon Epithelial Cells Gastroenterology. 136: A-319-A-320. DOI: 10.1016/S0016-5085(09)61462-1  0.492
2008 Flaishon L, Hart G, Zelman E, Moussion C, Grabovsky V, Lapidot Tal G, Feigelson S, Margalit R, Harmelin A, Avin-Wittenberg T, Shoseyov D, Alon R, Girard JP, Shachar I. Anti-inflammatory effects of an inflammatory chemokine: CCL2 inhibits lymphocyte homing by modulation of CCL21-triggered integrin-mediated adhesions. Blood. 112: 5016-25. PMID 18802011 DOI: 10.1182/Blood-2007-12-129122  0.772
2008 Sapoznikov A, Pewzner-Jung Y, Kalchenko V, Krauthgamer R, Shachar I, Jung S. Perivascular clusters of dendritic cells provide critical survival signals to B cells in bone marrow niches. Nature Immunology. 9: 388-95. PMID 18311142 DOI: 10.1038/Ni1571  0.499
2008 Gore Y, Starlets D, Maharshak N, Becker-Herman S, Kaneyuki U, Leng L, Bucala R, Shachar I. Macrophage migration inhibitory factor induces B cell survival by activation of a CD74-CD44 receptor complex. The Journal of Biological Chemistry. 283: 2784-92. PMID 18056708 DOI: 10.1074/Jbc.M703265200  0.845
2008 Hart G, Avin-Wittenberg T, Shachar I. IL-15 regulates immature B-cell homing in an Ly49D-, IL-12 , and IL-18 dependent manner. Blood. 111: 50-9. PMID 17901247 DOI: 10.1182/Blood-2007-07-099598  0.51
2008 Hartmann TN, Grabovsky V, Wang W, Desch P, Wollner S, Binsky I, Vallon-Eberhard A, Sapoznikow A, Haran M, Shachar I, Burger M, Honczarenko M, Greil R, Alon R. Circulating B-cell chronic lymphocytic leukemia cells display impaired migration to lymph nodes due to reduced LFA-1 expression Blood. 112: 3135-3135. DOI: 10.1182/Blood.V112.11.3135.3135  0.59
2007 Lantner F, Starlets D, Gore Y, Flaishon L, Yamit-Hezi A, Dikstein R, Leng L, Bucala R, Machluf Y, Oren M, Shachar I. CD74 induces TAp63 expression leading to B-cell survival. Blood. 110: 4303-11. PMID 17846227 DOI: 10.1182/Blood-2007-04-087486  0.835
2007 Binsky I, Haran M, Starlets D, Gore Y, Lantner F, Harpaz N, Leng L, Goldenberg DM, Shvidel L, Berrebi A, Bucala R, Shachar I. IL-8 secreted in a macrophage migration-inhibitory factor- and CD74-dependent manner regulates B cell chronic lymphocytic leukemia survival. Proceedings of the National Academy of Sciences of the United States of America. 104: 13408-13. PMID 17686984 DOI: 10.1073/Pnas.0701553104  0.852
2007 Hart G, Flaishon L, Shachar I. IL-12 and IL-18 down-regulate B cell migration in an Ly49D-dependent manner. European Journal of Immunology. 37: 1996-2007. PMID 17557376 DOI: 10.1002/Eji.200737083  0.817
2007 Schori H, Shechter R, Shachar I, Schwartz M. Genetic manipulation of CD74 in mouse strains of different backgrounds can result in opposite responses to central nervous system injury. Journal of Immunology (Baltimore, Md. : 1950). 178: 163-71. PMID 17182551 DOI: 10.4049/Jimmunol.178.1.163  0.482
2006 Wald O, Weiss ID, Wald H, Shoham H, Bar-Shavit Y, Beider K, Galun E, Weiss L, Flaishon L, Shachar I, Nagler A, Lu B, Gerard C, Gao JL, Mishani E, et al. IFN-gamma acts on T cells to induce NK cell mobilization and accumulation in target organs. Journal of Immunology (Baltimore, Md. : 1950). 176: 4716-29. PMID 16585565 DOI: 10.4049/Jimmunol.176.8.4716  0.789
2006 Starlets D, Gore Y, Binsky I, Haran M, Harpaz N, Shvidel L, Becker-Herman S, Berrebi A, Shachar I. Cell-surface CD74 initiates a signaling cascade leading to cell proliferation and survival. Blood. 107: 4807-16. PMID 16484589 DOI: 10.1182/Blood-2005-11-4334  0.831
2006 Binsky I, Haran M, Starlets D, Harpaz N, Shvidel L, Berrebi A, Shachar I. CD74 Is a Novel Survival Receptor in Chronic Lymphocytic Leukemia. Blood. 108: 2812-2812. DOI: 10.1182/Blood.V108.11.2812.2812  0.589
2005 Hart G, Flaishon L, Becker-Herman S, Shachar I. Tight regulation of IFN-gamma transcription and secretion in immature and mature B cells by the inhibitory MHC class I receptor, Ly49G2. Journal of Immunology (Baltimore, Md. : 1950). 175: 5034-42. PMID 16210606 DOI: 10.4049/Jimmunol.175.8.5034  0.833
2005 Becker-Herman S, Arie G, Medvedovsky H, Kerem A, Shachar I. CD74 is a member of the regulated intramembrane proteolysis-processed protein family. Molecular Biology of the Cell. 16: 5061-9. PMID 16107560 DOI: 10.1091/Mbc.E05-04-0327  0.469
2004 Haran M, Chebatco S, Flaishon L, Lantner F, Harpaz N, Valinsky L, Berrebi A, Shachar I. Grb7 expression and cellular migration in chronic lymphocytic leukemia: a comparative study of early and advanced stage disease. Leukemia. 18: 1948-50. PMID 15470489 DOI: 10.1038/Sj.Leu.2403512  0.746
2004 Flaishon L, Becker-Herman S, Hart G, Levo Y, Kuziel WA, Shachar I. Expression of the chemokine receptor CCR2 on immature B cells negatively regulates their cytoskeletal rearrangement and migration. Blood. 104: 933-41. PMID 15126315 DOI: 10.1182/Blood-2003-11-4013  0.837
2004 Topilski I, Flaishon L, Naveh Y, Harmelin A, Levo Y, Shachar I. The anti-inflammatory effects of 1,25-dihydroxyvitamin D3 on Th2 cells in vivo are due in part to the control of integrin-mediated T lymphocyte homing. European Journal of Immunology. 34: 1068-76. PMID 15048717 DOI: 10.1002/Eji.200324532  0.773
2003 Hart G, Flaishon L, Becker-Herman S, Shachar I. Ly49D receptor expressed on immature B cells regulates their IFN-gamma secretion, actin polymerization, and homing. Journal of Immunology (Baltimore, Md. : 1950). 171: 4630-8. PMID 14568937 DOI: 10.4049/Jimmunol.171.9.4630  0.83
2003 Matza D, Kerem A, Shachar I. Invariant chain, a chain of command. Trends in Immunology. 24: 264-8. PMID 12738421 DOI: 10.1016/S1471-4906(03)00073-5  0.401
2002 Matza D, Kerem A, Medvedovsky H, Lantner F, Shachar I. Invariant chain-induced B cell differentiation requires intramembrane proteolytic release of the cytosolic domain. Immunity. 17: 549-60. PMID 12433362 DOI: 10.1016/S1074-7613(02)00455-7  0.502
2002 Schori H, Lantner F, Shachar I, Schwartz M. Severe immunodeficiency has opposite effects on neuronal survival in glutamate-susceptible and -resistant mice: adverse effect of B cells. Journal of Immunology (Baltimore, Md. : 1950). 169: 2861-5. PMID 12218098 DOI: 10.4049/Jimmunol.169.6.2861  0.433
2002 Becker-Herman S, Lantner F, Shachar I. Id2 negatively regulates B cell differentiation in the spleen. Journal of Immunology (Baltimore, Md. : 1950). 168: 5507-13. PMID 12023345 DOI: 10.4049/Jimmunol.168.11.5507  0.582
2002 Flaishon L, Topilski I, Shoseyov D, Hershkoviz R, Fireman E, Levo Y, Marmor S, Shachar I. Cutting edge: anti-inflammatory properties of low levels of IFN-gamma. Journal of Immunology (Baltimore, Md. : 1950). 168: 3707-11. PMID 11937520 DOI: 10.4049/Jimmunol.168.8.3707  0.784
2002 Matza D, Lantner F, Bogoch Y, Flaishon L, Hershkoviz R, Shachar I. Invariant chain induces B cell maturation in a process that is independent of its chaperonic activity. Proceedings of the National Academy of Sciences of the United States of America. 99: 3018-23. PMID 11867743 DOI: 10.1073/Pnas.052703299  0.815
2002 Silkov A, Wolstein O, Shachar I, Dikstein R. Enhanced apoptosis of B and T lymphocytes in TAFII105 dominant-negative transgenic mice is linked to nuclear factor-kappa B. The Journal of Biological Chemistry. 277: 17821-9. PMID 11856754 DOI: 10.1074/Jbc.M200696200  0.42
2002 Topilski I, Harmelin A, Flavell RA, Levo Y, Shachar I. Preferential Th1 immune response in invariant chain-deficient mice. Journal of Immunology (Baltimore, Md. : 1950). 168: 1610-7. PMID 11823488 DOI: 10.4049/Jimmunol.168.4.1610  0.381
2001 Flaishon L, Lantner F, Hershkoviz R, Levo Y, Shachar I. Low levels of IFN-gamma down-regulate the integrin-dependent adhesion of B cells by activating a pathway that interferes with cytoskeleton rearrangement. The Journal of Biological Chemistry. 276: 46701-6. PMID 11585817 DOI: 10.1074/Jbc.M103484200  0.829
2001 Matza D, Wolstein O, Dikstein R, Shachar I. Invariant Chain Induces B Cell Maturation by Activating a TAF II105-NFκB-dependent Transcription Program Journal of Biological Chemistry. 276: 27203-27206. PMID 11371575 DOI: 10.1074/Jbc.M104684200  0.564
2000 Flaishon L, Hershkoviz R, Lantner F, Lider O, Alon R, Levo Y, Flavell RA, Shachar I. Autocrine secretion of interferon gamma negatively regulates homing of immature B cells. The Journal of Experimental Medicine. 192: 1381-8. PMID 11067886 DOI: 10.1084/Jem.192.9.1381  0.812
2000 Pierre P, Shachar I, Matza D, Gatti E, Flavell RA, Mellman I. Invariant chain controls H2-M proteolysis in mouse splenocytes and dendritic cells. The Journal of Experimental Medicine. 191: 1057-62. PMID 10727467 DOI: 10.1084/Jem.191.6.1057  0.4
1996 Winitz D, Shachar I, Elkabetz Y, Amitay R, Samuelov M, Bar-Nun S. Degradation of distinct assembly forms of immunoglobulin M occurs in multiple sites in permeabilized B cells. The Journal of Biological Chemistry. 271: 27645-51. PMID 8910354 DOI: 10.1074/Jbc.271.44.27645  0.391
1996 Shachar I, Flavell RA. Requirement for invariant chain in B cell maturation and function Science. 274: 106-108. PMID 8810244 DOI: 10.1126/Science.274.5284.106  0.5
1995 Shachar I, Elliott EA, Chasnoff B, Grewal IS, Flavell RA. Reconstitution of invariant chain function in transgenic mice in vivo by individual p31 and p41 isoforms Immunity. 3: 373-383. PMID 7553001 DOI: 10.1016/1074-7613(95)90121-3  0.347
1993 Rabinovich E, Bar-Nun S, Amitay R, Shachar I, Gur B, Taya M, Haimovich J. Different assembly species of IgM are directed to distinct degradation sites along the secretory pathway. The Journal of Biological Chemistry. 268: 24145-8. PMID 8226961  0.305
1992 Shachar I, Amitay R, Rabinovich E, Haimovich J, Bar-Nun S. Polymerization of secretory IgM in B lymphocytes is prevented by a prior targeting to a degradation pathway. The Journal of Biological Chemistry. 267: 24241-7. PMID 1447174  0.361
1992 Amitay R, Shachar I, Rabinovich E, Haimovich J, Bar-Nun S. Degradation of secretory immunoglobulin M in B lymphocytes occurs in a postendoplasmic reticulum compartment and is mediated by a cysteine protease. The Journal of Biological Chemistry. 267: 20694-700. PMID 1400386  0.324
1991 Amitay R, Bar-Nun S, Haimovich J, Rabinovich E, Shachar I. Post-translational regulation of IgM expression in B lymphocytes. Selective nonlysosomal degradation of assembled secretory IgM is temperature-dependent and occurs prior to the trans-Golgi. The Journal of Biological Chemistry. 266: 12568-73. PMID 1712024  0.364
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