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Joseph Heitman, PhD,MD - Publications

Affiliations: 
Molecular Genetics & Microbiology Duke University, Durham, NC 
Area:
Sex in Fungi, Signaling, Pathogenesis, Cryptococcus,
Website:
http://mgm.duke.edu/faculty/heitman/
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475 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Coelho MA, David-Palma M, Shea T, Bowers K, McGinley-Smith S, Mohammad AW, Gnirke A, Yurkov AM, Nowrousian M, Sun S, Cuomo CA, Heitman J. Comparative genomics of and reveals pathogenesis evolution and contrasting karyotype dynamics via intercentromeric recombination or chromosome fusion. Biorxiv : the Preprint Server For Biology. PMID 38234769 DOI: 10.1101/2023.12.27.573464  0.805
2024 Choi Y, Yu S-R, Lee Y, Na A-Y, Lee S, Heitman J, Seo R, Lee H-S, Lee J-S, Bahn Y-S. Casein kinase 2 complex: a central regulator of multiple pathobiological signaling pathways in . Mbio. e0327523. PMID 38193728 DOI: 10.1128/mbio.03275-23  0.592
2023 Navarro-Mendoza MI, Pérez-Arques C, Parker J, Kelly S, Heitman J. Alternative ergosterol biosynthetic pathways confer antifungal drug resistance in the human pathogens within the species complex. Biorxiv : the Preprint Server For Biology. PMID 38076934 DOI: 10.1101/2023.12.01.569667  0.779
2023 Sauters TJC, Roth C, Murray D, Sun S, Floyd Averette A, Onyishi CU, May RC, Heitman J, Magwene PM. Amoeba predation of Cryptococcus: A quantitative and population genomic evaluation of the accidental pathogen hypothesis. Plos Pathogens. 19: e1011763. PMID 37956179 DOI: 10.1371/journal.ppat.1011763  0.591
2023 Rivera A, Young Lim W, Park E, Dome PA, Hoy MJ, Spasojevic I, Sun S, Averette AF, Pina-Oviedo S, Juvvadi PR, Steinbach WJ, Ciofani M, Hong J, Heitman J. Enhanced fungal specificity and therapeutic efficacy of a C-22-modified FK520 analog against . Mbio. e0181023. PMID 37737622 DOI: 10.1128/mbio.01810-23  0.807
2023 Yadav V, Mohan R, Sun S, Heitman J. Calcineurin contributes to RNAi-mediated transgene silencing and small interfering RNA production in the human fungal pathogen . Biorxiv : the Preprint Server For Biology. PMID 37546757 DOI: 10.1101/2023.07.25.550548  0.676
2023 Coelho MA, Ianiri G, David-Palma M, Theelen B, Goyal R, Narayanan A, Lorch JM, Sanyal K, Boekhout T, Heitman J. Frequent transitions in mating-type locus chromosomal organization in and early steps in sexual reproduction. Proceedings of the National Academy of Sciences of the United States of America. 120: e2305094120. PMID 37523560 DOI: 10.1073/pnas.2305094120  0.82
2023 Gryganskyi AP, Golan J, Muszewska A, Idnurm A, Dolatabadi S, Mondo SJ, Kutovenko VB, Kutovenko VO, Gajdeczka MT, Anishchenko IM, Pawlowska J, Tran NV, Ebersberger I, Voigt K, Wang Y, ... ... Heitman J, et al. Sequencing the Genomes of the First Terrestrial Fungal Lineages: What Have We Learned? Microorganisms. 11. PMID 37513002 DOI: 10.3390/microorganisms11071830  0.604
2023 Alder-Rangel A, Bailão AM, Herrera-Estrella A, Rangel AEA, Gácser A, Gasch AP, Campos CBL, Peters C, Camelim F, Verde F, Gadd GM, Braus G, Eisermann I, Quinn J, Latgé JP, ... ... Heitman J, et al. The IV International Symposium on Fungal Stress and the XIII International Fungal Biology Conference. Fungal Biology. 127: 1157-1179. PMID 37495306 DOI: 10.1016/j.funbio.2023.04.006  0.421
2023 Yadav V, Heitman J. Calcineurin: The Achilles' heel of fungal pathogens. Plos Pathogens. 19: e1011445. PMID 37410706 DOI: 10.1371/journal.ppat.1011445  0.551
2023 Rivera A, Lim WY, Park E, Dome PA, Hoy MJ, Spasojevic I, Sun S, Averette AF, Pina-Oviedo S, Juvvadi PR, Steinbach WJ, Ciofani M, Hong J, Heitman J. Enhanced fungal specificity and therapeutic efficacy of a C-22 modified FK520 analog against . Biorxiv : the Preprint Server For Biology. PMID 37333270 DOI: 10.1101/2023.06.05.543712  0.805
2023 Coelho MA, Ianiri G, David-Palma M, Theelen B, Goyal R, Narayanan A, Sanyal K, Boekhout T, Heitman J. Genetic and genomic analysis of reveals transitions in mating-type locus chromosomal organization and early steps in sexual reproduction. Biorxiv : the Preprint Server For Biology. PMID 36993584 DOI: 10.1101/2023.03.25.534224  0.821
2023 Yadav V, Sun S, Heitman J. On the evolution of variation in sexual reproduction through the prism of eukaryotic microbes. Proceedings of the National Academy of Sciences of the United States of America. 120: e2219120120. PMID 36867686 DOI: 10.1073/pnas.2219120120  0.68
2023 Navarro-Mendoza MI, Pérez-Arques C, Heitman J. Heterochromatin and RNAi act independently to ensure genome stability in Mucorales human fungal pathogens. Proceedings of the National Academy of Sciences of the United States of America. 120: e2220475120. PMID 36745785 DOI: 10.1073/pnas.2220475120  0.748
2023 Gusa A, Yadav V, Roth C, Williams JD, Shouse EM, Magwene P, Heitman J, Jinks-Robertson S. Genome-wide analysis of heat stress-stimulated transposon mobility in the human fungal pathogen . Proceedings of the National Academy of Sciences of the United States of America. 120: e2209831120. PMID 36669112 DOI: 10.1073/pnas.2209831120  0.557
2023 Rivera A, Heitman J. Natural product ligands of FKBP12: Immunosuppressive antifungal agents FK506, rapamycin, and beyond. Plos Pathogens. 19: e1011056. PMID 36634035 DOI: 10.1371/journal.ppat.1011056  0.742
2022 Choi Y, Jeong E, Lee DG, Jin JH, So YS, Yu SR, Lee KJ, Ha Y, Lin CJ, Chen YL, Park JB, Cho HS, Averette AF, Heitman J, Lee KH, et al. Unraveling the Pathobiological Role of the Fungal KEOPS Complex in Cryptococcus neoformans. Mbio. e0294422. PMID 36377896 DOI: 10.1128/mbio.02944-22  0.786
2022 Case NT, Berman J, Blehert DS, Cramer RA, Cuomo C, Currie CR, Ene IV, Fisher MC, Fritz-Laylin LK, Gerstein AC, Glass NL, Gow NAR, Gurr SJ, Hittinger CT, Hohl TM, ... ... Heitman J, et al. The future of fungi: threats and opportunities. G3 (Bethesda, Md.). PMID 36179219 DOI: 10.1093/g3journal/jkac224  0.666
2022 Priest SJ, Yadav V, Roth C, Dahlmann TA, Kück U, Magwene PM, Heitman J. Uncontrolled transposition following RNAi loss causes hypermutation and antifungal drug resistance in clinical isolates of Cryptococcus neoformans. Nature Microbiology. 7: 1239-1251. PMID 35918426 DOI: 10.1038/s41564-022-01183-z  0.558
2022 Passer AR, Clancey SA, Shea T, David-Palma M, Averette AF, Boekhout T, Porcel BM, Nowrousian M, Cuomo CA, Sun S, Heitman J, Coelho MA. Obligate sexual reproduction of a homothallic fungus closely related to the pathogenic species complex. Elife. 11. PMID 35713948 DOI: 10.7554/eLife.79114  0.813
2022 Yadav V, Heitman J. On Fruits and Fungi: A Risk of Antifungal Usage in Food Storage and Distribution in Driving Drug Resistance in Candida auris. Mbio. e0073922. PMID 35575501 DOI: 10.1128/mbio.00739-22  0.525
2022 Dalimot JJ, Smith IMC, Gerkrath J, Hartmann S, Cornely OA, Lee SC, Heitman J, Rickerts V. Identification of Mucormycosis by Fluorescence In Situ Hybridization Targeting Ribosomal RNA in Tissue Samples. Journal of Fungi (Basel, Switzerland). 8. PMID 35330291 DOI: 10.3390/jof8030289  0.447
2022 Case NT, Song M, Fulford AH, Graham HV, Orphan VJ, Stajich JE, Casadevall A, Mustard J, Heitman J, Lollar BS, Cowen LE. Exploring Space via Astromycology: A Report on the CIFAR Programs and Inaugural Joint Meeting. Astrobiology. PMID 35196462 DOI: 10.1089/ast.2021.0186  0.497
2022 Sun S, Roth C, Floyd Averette A, Magwene PM, Heitman J. Epistatic genetic interactions govern morphogenesis during sexual reproduction and infection in a global human fungal pathogen. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35169080 DOI: 10.1073/pnas.2122293119  0.609
2021 Michelotti LA, Sun S, Heitman J, James TY. Clonal evolution in serially passaged Cryptococcus neoformans x deneoformans hybrids reveals a heterogenous landscape of genomic change. Genetics. PMID 34849836 DOI: 10.1093/genetics/iyab142  0.538
2021 Fu C, Davy A, Holmes S, Sun S, Yadav V, Gusa A, Coelho MA, Heitman J. Dynamic genome plasticity during unisexual reproduction in the human fungal pathogen Cryptococcus deneoformans. Plos Genetics. 17: e1009935. PMID 34843473 DOI: 10.1371/journal.pgen.1009935  0.788
2021 Boekhout T, Aime MC, Begerow D, Gabaldón T, Heitman J, Kemler M, Khayhan K, Lachance MA, Louis EJ, Sun S, Vu D, Yurkov A. The evolving species concepts used for yeasts: from phenotypes and genomes to speciation networks. Fungal Diversity. 109: 27-55. PMID 34720775 DOI: 10.1007/s13225-021-00475-9  0.56
2021 Schotanus K, Yadav V, Heitman J. Epigenetic dynamics of centromeres and neocentromeres in Cryptococcus deuterogattii. Plos Genetics. 17: e1009743. PMID 34464380 DOI: 10.1371/journal.pgen.1009743  0.532
2021 Yadav V, Sun S, Heitman J. Uniparental nuclear inheritance following bisexual mating in fungi. Elife. 10. PMID 34338631 DOI: 10.7554/eLife.66234  0.699
2021 Butler G, Heitman J, Idnurm A, James TY. On a Special Collection in MMBR on Sex in Fungi: Molecular Mechanisms and Evolutionary Implications. Microbiology and Molecular Biology Reviews : Mmbr. e0009421. PMID 34132102 DOI: 10.1128/MMBR.00094-21  0.565
2021 Butler G, Heitman J, Idnurm A, James TY. On a Special Collection in MMBR on Sex in Fungi: Molecular Mechanisms and Evolutionary Implications. Microbiology and Molecular Biology Reviews : Mmbr. e0009421. PMID 34132102 DOI: 10.1128/MMBR.00094-21  0.565
2021 Cowen LE, Heitman J. Showcasing Fungal Genetics & Genomics with the Genetics Society of America. Genetics. 217. PMID 33724422 DOI: 10.1093/genetics/iyaa034  0.528
2021 Cabrita A, David-Palma M, Brito PH, Heitman J, Coelho MA, Gonçalves P. Multiple Pathways to Homothallism in Closely Related Yeast Lineages in the Basidiomycota. Mbio. 12. PMID 33593979 DOI: 10.1128/mBio.03130-20  0.816
2021 Cowen LE, Heitman J. Showcasing Fungal Genetics & Genomics with the Genetics Society of America. G3 (Bethesda, Md.). 11. PMID 33585877 DOI: 10.1093/g3journal/jkaa041  0.528
2021 Roth C, Murray D, Scott A, Fu C, Averette AF, Sun S, Heitman J, Magwene PM. Pleiotropy and epistasis within and between signaling pathways defines the genetic architecture of fungal virulence. Plos Genetics. 17: e1009313. PMID 33493169 DOI: 10.1371/journal.pgen.1009313  0.676
2021 Priest SJ, Coelho MA, Mixão V, Clancey SA, Xu Y, Sun S, Gabaldón T, Heitman J. Factors enforcing the species boundary between the human pathogens Cryptococcus neoformans and Cryptococcus deneoformans. Plos Genetics. 17: e1008871. PMID 33465111 DOI: 10.1371/journal.pgen.1008871  0.567
2020 Bahn YS, Sun S, Heitman J, Lin X. Erratum: Microbe Profile: species complex. Microbiology (Reading, England). 166: 1191. PMID 33357260 DOI: 10.1099/mic.0.001013  0.711
2020 David-Palma M, Libkind D, Brito PH, Silva M, Bellora N, Coelho MA, Heitman J, Gonçalves P, Sampaio JP. The Untapped Australasian Diversity of Astaxanthin-Producing Yeasts with Biotechnological Potential- sp. nov. and sp. nov. Microorganisms. 8. PMID 33114402 DOI: 10.3390/microorganisms8111651  0.807
2020 Sun S, Hoy MJ, Heitman J. Fungal pathogens. Current Biology : Cb. 30: R1163-R1169. PMID 33022261 DOI: 10.1016/j.cub.2020.07.032  0.557
2020 Bahn YS, Sun S, Heitman J, Lin X. Microbe Profile: species complex. Microbiology (Reading, England). PMID 32956032 DOI: 10.1099/Mic.0.000973  0.761
2020 Applen Clancey S, Ruchti F, LeibundGut-Landmann S, Heitman J, Ianiri G. A Novel Mycovirus Evokes Transcriptional Rewiring in the Fungus and Stimulates Beta Interferon Production in Macrophages. Mbio. 11. PMID 32873760 DOI: 10.1128/Mbio.01534-20  0.355
2020 Ianiri G, Heitman J. Approaches for Genetic Discoveries in the Skin Commensal and Pathogenic Yeasts. Frontiers in Cellular and Infection Microbiology. 10: 393. PMID 32850491 DOI: 10.3389/Fcimb.2020.00393  0.374
2020 Jin JH, Lee KT, Hong J, Lee D, Jang EH, Kim JY, Lee Y, Lee SH, So YS, Jung KW, Lee DG, Jeong E, Lee M, Jang YB, Choi Y, ... ... Heitman J, et al. Genome-wide functional analysis of phosphatases in the pathogenic fungus Cryptococcus neoformans. Nature Communications. 11: 4212. PMID 32839469 DOI: 10.1038/S41467-020-18028-0  0.647
2020 Priest SJ, Yadav V, Heitman J. Advances in understanding the evolution of fungal genome architecture. F1000research. 9. PMID 32765832 DOI: 10.12688/F1000Research.25424.1  0.597
2020 Wurster S, Tatara AM, Albert ND, Ibrahim AS, Heitman J, Lee SC, Shetty AC, McCracken C, Graf KT, Mikos AG, Bruno VM, Kontoyiannis DP. Tornadic Shear Stress Induces a Transient, Calcineurin-Dependent Hypervirulent Phenotype in Mucorales Molds. Mbio. 11. PMID 32605990 DOI: 10.1128/Mbio.01414-20  0.563
2020 Ianiri G, Coelho MA, Ruchti F, Sparber F, McMahon TJ, Fu C, Bolejack M, Donovan O, Smutney H, Myler P, Dietrich F, Fox D, LeibundGut-Landmann S, Heitman J. HGT in the human and skin commensal : A bacterially derived flavohemoglobin is required for NO resistance and host interaction. Proceedings of the National Academy of Sciences of the United States of America. PMID 32576698 DOI: 10.1073/Pnas.2003473117  0.643
2020 Case NT, Heitman J, Cowen LE. The Rise of Fungi: A Report on the CIFAR Program Inaugural Meeting. G3 (Bethesda, Md.). 10: 1837-1842. PMID 32482729 DOI: 10.1534/G3.120.401271  0.546
2020 Fisher MC, Gurr SJ, Cuomo CA, Blehert DS, Jin H, Stukenbrock EH, Stajich JE, Kahmann R, Boone C, Denning DW, Gow NAR, Klein BS, Kronstad JW, Sheppard DC, Taylor JW, ... ... Heitman J, et al. Threats Posed by the Fungal Kingdom to Humans, Wildlife, and Agriculture. Mbio. 11. PMID 32371596 DOI: 10.1128/Mbio.00449-20  0.605
2020 Schotanus K, Heitman J. Centromere deletion in leads to neocentromere formation and chromosome fusions. Elife. 9. PMID 32310085 DOI: 10.7554/Elife.56026  0.342
2020 Gusa A, Williams JD, Cho JE, Averette AF, Sun S, Shouse EM, Heitman J, Alspaugh JA, Jinks-Robertson S. Transposon mobilization in the human fungal pathogen is mutagenic during infection and promotes drug resistance in vitro. Proceedings of the National Academy of Sciences of the United States of America. PMID 32303657 DOI: 10.1073/Pnas.2001451117  0.604
2020 Yadav V, Sun S, Coelho MA, Heitman J. Centromere scission drives chromosome shuffling and reproductive isolation. Proceedings of the National Academy of Sciences of the United States of America. PMID 32193338 DOI: 10.1073/Pnas.1918659117  0.726
2020 Juvvadi PR, Bobay BG, Gobeil SMC, Cole DC, Venters RA, Heitman J, Spicer LD, Steinbach WJ. FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus. Biochemical and Biophysical Research Communications. PMID 32192767 DOI: 10.1016/J.Bbrc.2020.03.062  0.315
2020 Fang Y, Coelho MA, Shu H, Schotanus K, Thimmappa BC, Yadav V, Chen H, Malc EP, Wang J, Mieczkowski PA, Kronmiller B, Tyler BM, Sanyal K, Dong S, Nowrousian M, ... Heitman J, et al. Long transposon-rich centromeres in an oomycete reveal divergence of centromere features in Stramenopila-Alveolata-Rhizaria lineages. Plos Genetics. 16: e1008646. PMID 32150559 DOI: 10.1371/Journal.Pgen.1008646  0.735
2020 Vellanki S, Billmyre RB, Lorenzen A, Campbell M, Turner B, Huh EY, Heitman J, Lee SC. A Novel Resistance Pathway for Calcineurin Inhibitors in the Human-Pathogenic Mucorales Mucor circinelloides. Mbio. 11. PMID 31992620 DOI: 10.1128/Mbio.02949-19  0.801
2020 Sankaranarayanan SR, Ianiri G, Coelho MA, Reza MH, Thimmappa BC, Ganguly P, Vadnala RN, Sun S, Siddharthan R, Tellgren-Roth C, Dawson TL, Heitman J, Sanyal K. Loss of centromere function drives karyotype evolution in closely related species. Elife. 9. PMID 31958060 DOI: 10.7554/Elife.53944  0.725
2020 Billmyre RB, Applen Clancey S, Li LX, Doering TL, Heitman J. 5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus. Nature Communications. 11: 127. PMID 31913284 DOI: 10.1038/S41467-019-13890-Z  0.737
2020 Miccoli C, Palmieri D, De Curtis F, Lima G, Heitman J, Castoria R, Ianiri G. The necessity for molecular classification of basidiomycetous biocontrol yeasts Biocontrol. 65: 489-500. DOI: 10.1007/S10526-020-10008-Z  0.366
2019 Sun S, Fu C, Ianiri G, Heitman J. The Pheromone and Pheromone Receptor Mating-Type Locus Is Involved in Controlling Uniparental Mitochondrial Inheritance in . Genetics. PMID 31888949 DOI: 10.1534/Genetics.119.302824  0.741
2019 Ianiri G, Fang Y, Dahlmann TA, Clancey SA, Janbon G, Kück U, Heitman J. Mating-Type Specific Ribosomal Proteins Control Aspects of Sexual Reproduction in . Genetics. PMID 31882399 DOI: 10.1534/Genetics.119.302740  0.406
2019 Ergin Ç, Şengül M, Aksoy L, Döğen A, Sun S, Averette AF, Cuomo CA, Seyedmousavi S, Heitman J, Ilkit M. Recovered From Olive Trees () in Turkey Reveal Allopatry With African and South American Lineages. Frontiers in Cellular and Infection Microbiology. 9: 384. PMID 31788454 DOI: 10.3389/Fcimb.2019.00384  0.609
2019 Chang Z, Heitman J. Drug-Resistant Epimutants Exhibit Organ-Specific Stability and Induction during Murine Infections Caused by the Human Fungal Pathogen Mucor circinelloides. Mbio. 10. PMID 31690679 DOI: 10.1128/Mbio.02579-19  0.803
2019 Son YE, Fu C, Jung WH, Oh SH, Kwak JH, Cardenas ME, Heitman J, Park HS. Pbp1-Interacting Protein Mkt1 Regulates Virulence and Sexual Reproduction in . Frontiers in Cellular and Infection Microbiology. 9: 355. PMID 31681631 DOI: 10.3389/Fcimb.2019.00355  0.659
2019 Navarro-Mendoza MI, Pérez-Arques C, Panchal S, Nicolás FE, Mondo SJ, Ganguly P, Pangilinan J, Grigoriev IV, Heitman J, Sanyal K, Garre V. Early Diverging Fungus Mucor circinelloides Lacks Centromeric Histone CENP-A and Displays a Mosaic of Point and Regional Centromeres. Current Biology : Cb. PMID 31679929 DOI: 10.1016/J.Cub.2019.09.024  0.798
2019 Park HS, Lee SC, Cardenas ME, Heitman J. Calcium-Calmodulin-Calcineurin Signaling: A Globally Conserved Virulence Cascade in Eukaryotic Microbial Pathogens. Cell Host & Microbe. 26: 453-462. PMID 31600499 DOI: 10.1016/J.Chom.2019.08.004  0.577
2019 Metin B, Heitman J. She Loves Me, She Loves Me Not: On the Dualistic Asexual/Sexual Nature of Dermatophyte Fungi. Mycopathologia. PMID 31578669 DOI: 10.1007/S11046-019-00390-3  0.325
2019 Juvvadi PR, Fox D, Bobay BG, Hoy MJ, Gobeil SMC, Venters RA, Chang Z, Lin JJ, Averette AF, Cole DC, Barrington BC, Wheaton JD, Ciofani M, Trzoss M, Li X, ... ... Heitman J, et al. Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents. Nature Communications. 10: 4275. PMID 31537789 DOI: 10.1038/S41467-019-12199-1  0.801
2019 Sun S, Coelho MA, David-Palma M, Priest S, Heitman J. The Evolution of Sexual Reproduction and the Mating-Type Locus: Links to Pathogenesis of Human Pathogenic Fungi. Annual Review of Genetics. PMID 31537103 DOI: 10.1146/Annurev-Genet-120116-024755  0.821
2019 Fu C, Thielhelm TP, Heitman J. Unisexual reproduction promotes competition for mating partners in the global human fungal pathogen Cryptococcus deneoformans. Plos Genetics. 15: e1008394. PMID 31536509 DOI: 10.1371/Journal.Pgen.1008394  0.647
2019 Sun S, Coelho MA, Heitman J, Nowrousian M. Convergent evolution of linked mating-type loci in basidiomycete fungi. Plos Genetics. 15: e1008365. PMID 31490920 DOI: 10.1371/Journal.Pgen.1008365  0.628
2019 Heitman J. : The Fungal Kingdom as a Rosetta Stone for Biology and Medicine. Genetics. 213: 1-7. PMID 31488591 DOI: 10.1534/Genetics.119.302537  0.403
2019 Fu C, Coelho MA, David-Palma M, Priest SJ, Heitman J. Genetic and genomic evolution of sexual reproduction: echoes from LECA to the fungal kingdom. Current Opinion in Genetics & Development. 58: 70-75. PMID 31473482 DOI: 10.1016/J.Gde.2019.07.008  0.8
2019 Sun S, Lin X, Coelho MA, Heitman J. Mating-System Evolution: All Roads Lead to Selfing. Current Biology : Cb. 29: R743-R746. PMID 31386850 DOI: 10.1016/J.Cub.2019.06.073  0.634
2019 Chang Z, Yadav V, Chan Lee S, Heitman J. Epigenetic mechanisms of drug resistance in fungi. Fungal Genetics and Biology : Fg & B. 103253. PMID 31325489 DOI: 10.1016/J.Fgb.2019.103253  0.791
2019 Ianiri G, Dagotto G, Sun S, Heitman J. Advancing Functional Genetics Through -Mediated Insertional Mutagenesis and CRISPR/Cas9 in the Commensal and Pathogenic Yeast . Genetics. PMID 31243056 DOI: 10.1534/Genetics.119.302329  0.594
2019 Passer AR, Coelho MA, Billmyre RB, Nowrousian M, Mittelbach M, Yurkov AM, Averette AF, Cuomo CA, Sun S, Heitman J. Genetic and Genomic Analyses Reveal Boundaries between Species Closely Related to Pathogens. Mbio. 10. PMID 31186317 DOI: 10.1128/Mbio.00764-19  0.814
2019 Mueller KD, Zhang H, Serrano CR, Billmyre RB, Huh EY, Wiemann P, Keller NP, Wang Y, Heitman J, Lee SC. Gastrointestinal microbiota alteration induced by Mucor circinelloides in a murine model. Journal of Microbiology (Seoul, Korea). PMID 31012059 DOI: 10.1007/S12275-019-8682-X  0.782
2019 Rutherford JC, Bahn YS, van den Berg B, Heitman J, Xue C. Nutrient and Stress Sensing in Pathogenic Yeasts. Frontiers in Microbiology. 10: 442. PMID 30930866 DOI: 10.3389/Fmicb.2019.00442  0.754
2019 Amend A, Burgaud G, Cunliffe M, Edgcomb VP, Ettinger CL, Gutiérrez MH, Heitman J, Hom EFY, Ianiri G, Jones AC, Kagami M, Picard KT, Quandt CA, Raghukumar S, Riquelme M, et al. Fungi in the Marine Environment: Open Questions and Unsolved Problems. Mbio. 10. PMID 30837337 DOI: 10.1128/Mbio.01189-18  0.333
2019 Applen Clancey S, Ciccone EJ, Coelho MA, Davis J, Ding L, Betancourt R, Glaubiger S, Lee Y, Holland SM, Gilligan P, Sung J, Heitman J. VGIIa Infection Associated with Travel to the Pacific Northwest Outbreak Region in an Anti-Granulocyte-Macrophage Colony-Stimulating Factor Autoantibody-Positive Patient in the United States. Mbio. 10. PMID 30755511 DOI: 10.1128/Mbio.02733-18  0.323
2019 Chang Z, Billmyre RB, Lee SC, Heitman J. Broad antifungal resistance mediated by RNAi-dependent epimutation in the basal human fungal pathogen Mucor circinelloides. Plos Genetics. 15: e1007957. PMID 30742617 DOI: 10.1371/Journal.Pgen.1007957  0.803
2019 Pérez-Arques C, Navarro-Mendoza MI, Murcia L, Lax C, Martínez-García P, Heitman J, Nicolás FE, Garre V. Thrives inside the Phagosome through an Atf-Mediated Germination Pathway. Mbio. 10. PMID 30723131 DOI: 10.1128/Mbio.02765-18  0.817
2019 Sun S, Priest SJ, Heitman J. Cryptococcus neoformans Mating and Genetic Crosses. Current Protocols in Microbiology. e75. PMID 30661293 DOI: 10.1002/Cpmc.75  0.627
2019 Metin B, Döğen A, Yıldırım E, Sybren de Hoog G, Heitman J, Ilkit M. Mating type (MAT) locus and possible sexuality of the opportunistic pathogen Exophiala dermatitidis. Fungal Genetics and Biology : Fg & B. PMID 30611834 DOI: 10.1016/J.Fgb.2018.12.011  0.394
2018 Lee Y, Lee KT, Lee SJ, Beom JY, Hwangbo A, Jung JA, Song MC, Yoo YJ, Kang SH, Averette AF, Heitman J, Yoon YJ, Cheong E, Bahn YS. and assessment of FK506 analogs as novel antifungal drug candidates. Antimicrobial Agents and Chemotherapy. PMID 30181374 DOI: 10.1128/Aac.01627-18  0.601
2018 Wang L, Pittman KJ, Barker JR, Salinas RE, Stanaway IB, Williams GD, Carroll RJ, Balmat T, Ingham A, Gopalakrishnan AM, Gibbs KD, Antonia AL, Heitman J, Lee SC, et al. An Atlas of Genetic Variation Linking Pathogen-Induced Cellular Traits to Human Disease. Cell Host & Microbe. 24: 308-323.e6. PMID 30092202 DOI: 10.1016/J.Chom.2018.07.007  0.587
2018 Jung KW, Lee KT, Averette AF, Hoy MJ, Everitt J, Heitman J, Bahn YS. Evolutionarily Conserved and Divergent Roles of Unfolded Protein Response (UPR) in the Pathogenic Cryptococcus Species Complex. Scientific Reports. 8: 8132. PMID 29802329 DOI: 10.1038/S41598-018-26405-5  0.649
2018 Garcia-Hermoso D, Criscuolo A, Lee SC, Legrand M, Chaouat M, Denis B, Lafaurie M, Rouveau M, Soler C, Schaal JV, Mimoun M, Mebazaa A, Heitman J, Dromer F, Brisse S, et al. Outbreak of Invasive Wound Mucormycosis in a Burn Unit Due to Multiple Strains of Mucor circinelloides f. circinelloides Resolved by Whole-Genome Sequencing. Mbio. 9. PMID 29691339 DOI: 10.1128/Mbio.00573-18  0.563
2018 Ianiri G, Heitman J, Scheynius A. The Skin Commensal Yeast Malassezia globosa Thwarts Bacterial Biofilms to Benefit the Host. The Journal of Investigative Dermatology. 138: 1026-1029. PMID 29681390 DOI: 10.1016/J.Jid.2018.01.008  0.345
2018 Gryganskyi AP, Golan J, Dolatabadi S, Mondo S, Robb S, Idnurm A, Muszewska A, Steczkiewicz K, Masonjones S, Liao HL, Gajdeczka MT, Anike F, Vuek A, Anishchenko IM, Voigt K, ... ... Heitman J, et al. Phylogenetic and Phylogenomic Definition of Species. G3 (Bethesda, Md.). PMID 29674435 DOI: 10.1534/G3.118.200235  0.648
2018 Roth C, Sun S, Billmyre RB, Heitman J, Magwene PM. A High Resolution Map of Meiotic Recombination inDemonstrates Decreased Recombination in Unisexual Reproduction. Genetics. PMID 29625994 DOI: 10.1534/Genetics.118.300996  0.795
2018 Yadav V, Sun S, Billmyre RB, Thimmappa BC, Shea T, Lintner R, Bakkeren G, Cuomo CA, Heitman J, Sanyal K. RNAi is a critical determinant of centromere evolution in closely related fungi. Proceedings of the National Academy of Sciences of the United States of America. PMID 29507212 DOI: 10.1073/Pnas.1713725115  0.799
2018 Persinoti GF, Martinez DA, Li W, Döğen A, Billmyre RB, Averette A, Goldberg JM, Shea T, Young S, Zeng Q, Oliver BG, Barton R, Metin B, Hilmioğlu-Polat S, Ilkit M, ... ... Heitman J, et al. Whole Genome Analysis Illustrates Global Clonal Population Structure of the Ubiquitous Dermatophyte Pathogen. Genetics. PMID 29467168 DOI: 10.1534/Genetics.117.300573  0.787
2017 Jung WH, Son YE, Oh SH, Fu C, Kim HS, Kwak JH, Cardenas ME, Heitman J, Park HS. Had1 Is Required for Cell Wall Integrity and Fungal Virulence in Cryptococcus neoformans. G3 (Bethesda, Md.). PMID 29233914 DOI: 10.1534/G3.117.300444  0.662
2017 Fu C, Donadio N, Cardenas ME, Heitman J. Dissecting the Roles of the Calcineurin Pathway in Unisexual Reproduction, Stress Responses, and Virulence in Cryptococcus deneoformans. Genetics. PMID 29233811 DOI: 10.1534/Genetics.117.300422  0.661
2017 Ianiri G, Applen Clancey S, Lee SC, Heitman J. Erratum for Ianiri et al., "FKBP12-Dependent Inhibition of Calcineurin Mediates Immunosuppressive Antifungal Drug Action in Malassezia". Mbio. 8. PMID 29208751 DOI: 10.1128/Mbio.02055-17  0.481
2017 Fu C, Heitman J. PRM1 and KAR5 function in cell-cell fusion and karyogamy to drive distinct bisexual and unisexual cycles in the Cryptococcus pathogenic species complex. Plos Genetics. 13: e1007113. PMID 29176784 DOI: 10.1371/Journal.Pgen.1007113  0.661
2017 Ianiri G, Applen Clancey S, Lee SC, Heitman J. FKBP12-Dependent Inhibition of Calcineurin Mediates Immunosuppressive Antifungal Drug Action in Malassezia. Mbio. 8. PMID 29066552 DOI: 10.1128/Mbio.01752-17  0.578
2017 Billmyre RB, Clancey SA, Heitman J. Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in Cryptococcus deuterogattii. Elife. 6. PMID 28948913 DOI: 10.7554/Elife.28802  0.749
2017 Billmyre RB, Heitman J. Genetic and epigenetic engines of diversity in pathogenic microbes. Plos Pathogens. 13: e1006468. PMID 28910393 DOI: 10.1371/Journal.Ppat.1006468  0.709
2017 Umen J, Goodenough U, Heitman J. Eukaryotic Sexual Reproduction Evoked "with a Little Help from My Friends". Cell. 170: 1059-1061. PMID 28886378 DOI: 10.1016/J.Cell.2017.08.038  0.34
2017 Sun S, Yadav V, Billmyre RB, Cuomo CA, Nowrousian M, Wang L, Souciet JL, Boekhout T, Porcel B, Wincker P, Granek JA, Sanyal K, Heitman J. Fungal genome and mating system transitions facilitated by chromosomal translocations involving intercentromeric recombination. Plos Biology. 15: e2002527. PMID 28800596 DOI: 10.1371/Journal.Pbio.2002527  0.823
2017 Döğen A, Metin B, Ilkit M, de Hoog GS, Heitman J. MTL genotypes, phenotypic switching, and susceptibility profiles of Candida parapsilosis species group compared to Lodderomyces elongisporus. Plos One. 12: e0182653. PMID 28771588 DOI: 10.1371/Journal.Pone.0182653  0.341
2017 Lee SC, Heitman J. Dynamics of parasitophorous vacuoles formed by the microsporidian pathogen Encephalitozoon cuniculi. Fungal Genetics and Biology : Fg & B. PMID 28754285 DOI: 10.1016/J.Fgb.2017.07.006  0.586
2017 Rhodes J, Desjardins CA, Sykes SM, Beale MA, Vanhove M, Sakthikumar S, Chen Y, Gujja S, Saif S, Chowdhary A, Lawson DJ, Ponzio V, Colombo AL, Meyer W, Engelthaler DM, ... ... Heitman J, et al. Tracing Genetic Exchange and Biogeography of Cryptococcus neoformans var. grubii at the Global Population Level. Genetics. PMID 28679543 DOI: 10.1534/Genetics.117.203836  0.39
2017 Desjardins CA, Giamberardino C, Sykes SM, Yu CH, Tenor JL, Chen Y, Yang T, Jones AM, Sun S, Haverkamp MR, Heitman J, Litvintseva AP, Perfect JR, Cuomo CA. Population genomics and the evolution of virulence in the fungal pathogen Cryptococcus neoformans. Genome Research. PMID 28611159 DOI: 10.1101/Gr.218727.116  0.64
2017 Garcia A, Adedoyin G, Heitman J, Lee SC. Construction of a Recyclable Genetic Maker and Serial Gene Deletions in the Human Pathogenic Mucorales Mucor circinelloides. G3 (Bethesda, Md.). PMID 28476909 DOI: 10.1534/G3.117.041095  0.602
2017 Chow EW, Clancey SA, Billmyre RB, Averette AF, Granek JA, Mieczkowski P, Cardenas ME, Heitman J. Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans. Plos Genetics. 13: e1006667. PMID 28376087 DOI: 10.1371/Journal.Pgen.1006667  0.744
2017 Calo S, Nicolás FE, Lee SC, Vila A, Cervantes M, Torres-Martinez S, Ruiz-Vazquez RM, Cardenas ME, Heitman J. A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides. Plos Genetics. 13: e1006686. PMID 28339467 DOI: 10.1371/Journal.Pgen.1006686  0.773
2017 Springer DJ, Mohan R, Heitman J. Plants promote mating and dispersal of the human pathogenic fungus Cryptococcus. Plos One. 12: e0171695. PMID 28212396 DOI: 10.1371/Journal.Pone.0171695  0.347
2017 Zhu Y, Engström PG, Tellgren-Roth C, Baudo CD, Kennell JC, Sun S, Billmyre RB, Schröder MS, Andersson A, Holm T, Sigurgeirsson B, Wu G, Sankaranarayanan SR, Siddharthan R, Sanyal K, ... ... Heitman J, et al. Proteogenomics produces comprehensive and highly accurate protein-coding gene annotation in a complete genome assembly of Malassezia sympodialis. Nucleic Acids Research. PMID 28100699 DOI: 10.1093/Nar/Gkx006  0.801
2016 Ianiri G, Averette AF, Kingsbury JM, Heitman J, Idnurm A. Gene Function Analysis in the Ubiquitous Human Commensal and Pathogen Malassezia Genus. Mbio. 7. PMID 27899504 DOI: 10.1128/Mbio.01853-16  0.643
2016 Yang DH, Jung KW, Bang S, Lee JW, Song MH, Floyd-Averette A, Festa RA, Ianiri G, Idnurm A, Thiele DJ, Heitman J, Bahn YS. Rewiring of Signaling Networks Modulating Thermotolerance in the Human Pathogen Cryptococcus neoformans. Genetics. PMID 27866167 DOI: 10.1534/Genetics.116.190595  0.745
2016 Chang YL, Yu SJ, Heitman J, Wellington M, Chen YL. New Facets of Antifungal Therapy. Virulence. 0. PMID 27820668 DOI: 10.1080/21505594.2016.1257457  0.689
2016 Metin B, Heitman J. Sexual Reproduction in Dermatophytes. Mycopathologia. PMID 27696123 DOI: 10.1007/S11046-016-0072-X  0.358
2016 Polvi EJ, Averette AF, Lee SC, Kim T, Bahn YS, Veri AO, Robbins N, Heitman J, Cowen LE. Metal Chelation as a Powerful Strategy to Probe Cellular Circuitry Governing Fungal Drug Resistance and Morphogenesis. Plos Genetics. 12: e1006350. PMID 27695031 DOI: 10.1371/Journal.Pgen.1006350  0.783
2016 Lee KT, So YS, Yang DH, Jung KW, Choi J, Lee DG, Kwon H, Jang J, Wang LL, Cha S, Meyers GL, Jeong E, Jin JH, Lee Y, Hong J, ... ... Heitman J, et al. Systematic functional analysis of kinases in the fungal pathogen Cryptococcus neoformans. Nature Communications. 7: 12766. PMID 27677328 DOI: 10.1038/Ncomms12766  0.646
2016 Park HS, Chow EW, Fu C, Soderblom EJ, Moseley MA, Heitman J, Cardenas ME. Calcineurin Targets Involved in Stress Survival and Fungal Virulence. Plos Pathogens. 12: e1005873. PMID 27611567 DOI: 10.1371/Journal.Ppat.1005873  0.625
2016 Shekhar-Guturja T, Gunaherath GM, Wijeratne EM, Lambert JP, Averette AF, Lee SC, Kim T, Bahn YS, Tripodi F, Ammar R, Döhl K, Niewola-Staszkowska K, Schmitt L, Loewith RJ, Roth FP, ... ... Heitman J, et al. Dual action antifungal small molecule modulates multidrug efflux and TOR signaling. Nature Chemical Biology. PMID 27571477 DOI: 10.1038/Nchembio.2165  0.78
2016 Kingsbury JM, Shamaprasad N, Billmyre RB, Heitman J, Cardenas ME. Cancer-associated isocitrate dehydrogenase mutations induce mitochondrial DNA instability. Human Molecular Genetics. PMID 27427385 DOI: 10.1093/Hmg/Ddw195  0.71
2016 Juvvadi PR, Lee SC, Heitman J, Steinbach WJ. Calcineurin in Fungal Virulence and Drug Resistance: Prospects for Harnessing Targeted Inhibition of Calcineurin for an Antifungal Therapeutic Approach. Virulence. 0. PMID 27325145 DOI: 10.1080/21505594.2016.1201250  0.568
2016 Corrochano LM, Kuo A, Marcet-Houben M, Polaino S, Salamov A, Villalobos-Escobedo JM, Grimwood J, Álvarez MI, Avalos J, Bauer D, Benito EP, Benoit I, Burger G, Camino LP, Cánovas D, ... ... Heitman J, et al. Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication. Current Biology : Cb. PMID 27238284 DOI: 10.1016/J.Cub.2016.04.038  0.808
2016 Tonthat NK, Juvvadi PR, Zhang H, Lee SC, Venters R, Spicer L, Steinbach WJ, Heitman J, Schumacher MA. Structures of Pathogenic Fungal FKBP12s Reveal Possible Self-Catalysis Function. Mbio. 7. PMID 27118592 DOI: 10.1128/Mbio.00492-16  0.577
2016 Feretzaki M, Billmyre RB, Clancey SA, Wang X, Heitman J. Gene Network Polymorphism Illuminates Loss and Retention of Novel RNAi Silencing Components in the Cryptococcus Pathogenic Species Complex. Plos Genetics. 12: e1005868. PMID 26943821 DOI: 10.1371/Journal.Pgen.1005868  0.831
2015 Heitman J. Evolution of sexual reproduction: a view from the Fungal Kingdom supports an evolutionary epoch with sex before sexes. Fungal Biology Reviews. 29: 108-117. PMID 26834823 DOI: 10.1016/J.Fbr.2015.08.002  0.355
2015 Sun S, Heitman J. From Two to One: Unipolar Sexual Reproduction. Fungal Biology Reviews. 29: 118-125. PMID 26744600 DOI: 10.1016/J.Fbr.2015.06.002  0.594
2015 Robbins N, Spitzer M, Yu T, Cerone RP, Averette AK, Bahn YS, Heitman J, Sheppard DC, Tyers M, Wright GD. An Antifungal Combination Matrix Identifies a Rich Pool of Adjuvant Molecules that Enhance Drug Activity against Diverse Fungal Pathogens. Cell Reports. PMID 26549450 DOI: 10.1016/J.Celrep.2015.10.018  0.636
2015 Heitman J. On the Discovery of TOR As the Target of Rapamycin. Plos Pathogens. 11: e1005245. PMID 26540102 DOI: 10.1371/Journal.Ppat.1005245  0.34
2015 Wu G, Zhao H, Li C, Rajapakse MP, Wong WC, Xu J, Saunders CW, Reeder NL, Reilman RA, Scheynius A, Sun S, Billmyre BR, Li W, Averette AF, Mieczkowski P, ... Heitman J, et al. Genus-Wide Comparative Genomics of Malassezia Delineates Its Phylogeny, Physiology, and Niche Adaptation on Human Skin. Plos Genetics. 11: e1005614. PMID 26539826 DOI: 10.1371/Journal.Pgen.1005614  0.658
2015 Farrer RA, Desjardins CA, Sakthikumar S, Gujja S, Saif S, Zeng Q, Chen Y, Voelz K, Heitman J, May RC, Fisher MC, Cuomo CA. Genome Evolution and Innovation across the Four Major Lineages of Cryptococcus gattii. Mbio. 6: e00868-15. PMID 26330512 DOI: 10.1128/Mbio.00868-15  0.436
2015 Kourist R, Bracharz F, Lorenzen J, Kracht ON, Chovatia M, Daum C, Deshpande S, Lipzen A, Nolan M, Ohm RA, Grigoriev IV, Sun S, Heitman J, Brück T, Nowrousian M. Genomics and Transcriptomics Analyses of the Oil-Accumulating Basidiomycete Yeast Trichosporon oleaginosus: Insights into Substrate Utilization and Alternative Evolutionary Trajectories of Fungal Mating Systems. Mbio. 6: e00918. PMID 26199329 DOI: 10.1128/Mbio.00918-15  0.61
2015 Desnos-Ollivier M, Patel S, Raoux-Barbot D, Heitman J, Dromer F. Cryptococcosis Serotypes Impact Outcome and Provide Evidence of Cryptococcus neoformans Speciation. Mbio. 6. PMID 26060271 DOI: 10.1128/Mbio.00311-15  0.35
2015 Lee SC, Li A, Calo S, Inoue M, Tonthat NK, Bain JM, Louw J, Shinohara ML, Erwig LP, Schumacher MA, Ko DC, Heitman J. Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides. Molecular Microbiology. PMID 26010100 DOI: 10.1111/Mmi.13071  0.608
2015 Jung KW, Yang DH, Maeng S, Lee KT, So YS, Hong J, Choi J, Byun HJ, Kim H, Bang S, Song MH, Lee JW, Kim MS, Kim SY, Ji JH, ... ... Heitman J, et al. Systematic functional profiling of transcription factor networks in Cryptococcus neoformans. Nature Communications. 6: 6757. PMID 25849373 DOI: 10.1038/Ncomms7757  0.634
2015 Kim H, Jung KW, Maeng S, Chen YL, Shin J, Shim JE, Hwang S, Janbon G, Kim T, Heitman J, Bahn YS, Lee I. Network-assisted genetic dissection of pathogenicity and drug resistance in the opportunistic human pathogenic fungus Cryptococcus neoformans. Scientific Reports. 5: 8767. PMID 25739925 DOI: 10.1038/Srep08767  0.796
2015 Fu C, Sun S, Billmyre RB, Roach KC, Heitman J. Unisexual versus bisexual mating in Cryptococcus neoformans: Consequences and biological impacts. Fungal Genetics and Biology : Fg & B. 78: 65-75. PMID 25173822 DOI: 10.1016/J.Fgb.2014.08.008  0.815
2015 Tiro AV, Springer DJ, Irby R, Averill F, Ottaviani A, Heitman J, Perfect JR. A case of cryptococcus gattii in Western Florida: An aggressive pathogen in an immunocompetent host Infectious Diseases in Clinical Practice. 23: 105-108. DOI: 10.1097/Ipc.0000000000000211  0.316
2014 Sun S, Billmyre RB, Mieczkowski PA, Heitman J. Unisexual reproduction drives meiotic recombination and phenotypic and karyotypic plasticity in Cryptococcus neoformans. Plos Genetics. 10: e1004849. PMID 25503976 DOI: 10.1371/Journal.Pgen.1004849  0.795
2014 Phadke SS, Feretzaki M, Clancey SA, Mueller O, Heitman J. Unisexual reproduction of Cryptococcus gattii. Plos One. 9: e111089. PMID 25337713 DOI: 10.1371/Journal.Pone.0111089  0.791
2014 Wollschlaeger C, Trevijano-Contador N, Wang X, Legrand M, Zaragoza O, Heitman J, Janbon G. Distinct and redundant roles of exonucleases in Cryptococcus neoformans: implications for virulence and mating. Fungal Genetics and Biology : Fg & B. 73: 20-8. PMID 25267175 DOI: 10.1016/J.Fgb.2014.09.007  0.407
2014 Ferreira-Paim K, Ferreira TB, Andrade-Silva L, Mora DJ, Springer DJ, Heitman J, Fonseca FM, Matos D, Melhem MS, Silva-Vergara ML. Phylogenetic analysis of phenotypically characterized Cryptococcus laurentii isolates reveals high frequency of cryptic species. Plos One. 9: e108633. PMID 25251413 DOI: 10.1371/Journal.Pone.0108633  0.347
2014 Roach KC, Heitman J. Unisexual reproduction reverses Muller's ratchet. Genetics. 198: 1059-69. PMID 25217049 DOI: 10.1534/Genetics.114.170472  0.419
2014 Lee SC, Heitman J. Sex in the Mucoralean fungi. Mycoses. 57: 18-24. PMID 25175551 DOI: 10.1111/Myc.12244  0.574
2014 Springer DJ, Billmyre RB, Filler EE, Voelz K, Pursall R, Mieczkowski PA, Larsen RA, Dietrich FS, May RC, Filler SG, Heitman J. Cryptococcus gattii VGIII isolates causing infections in HIV/AIDS patients in Southern California: identification of the local environmental source as arboreal. Plos Pathogens. 10: e1004285. PMID 25144534 DOI: 10.1371/Journal.Ppat.1004285  0.743
2014 Feretzaki M, Hardison SE, Wormley FL, Heitman J. Cryptococcus neoformans hyperfilamentous strain is hypervirulent in a murine model of cryptococcal meningoencephalitis. Plos One. 9: e104432. PMID 25093333 DOI: 10.1371/Journal.Pone.0104432  0.784
2014 Heitman J, Carter DA, Dyer PS, Soll DR. Sexual reproduction of human fungal pathogens. Cold Spring Harbor Perspectives in Medicine. 4. PMID 25085958 DOI: 10.1101/Cshperspect.A019281  0.431
2014 Calo S, Shertz-Wall C, Lee SC, Bastidas RJ, Nicolás FE, Granek JA, Mieczkowski P, Torres-Martínez S, Ruiz-Vázquez RM, Cardenas ME, Heitman J. Antifungal drug resistance evoked via RNAi-dependent epimutations. Nature. 513: 555-8. PMID 25079329 DOI: 10.1038/Nature13575  0.8
2014 Billmyre RB, Croll D, Li W, Mieczkowski P, Carter DA, Cuomo CA, Kronstad JW, Heitman J. Highly recombinant VGII Cryptococcus gattii population develops clonal outbreak clusters through both sexual macroevolution and asexual microevolution. Mbio. 5: e01494-14. PMID 25073643 DOI: 10.1128/Mbio.01494-14  0.79
2014 Lee SC, Billmyre RB, Li A, Carson S, Sykes SM, Huh EY, Mieczkowski P, Ko DC, Cuomo CA, Heitman J. Analysis of a food-borne fungal pathogen outbreak: virulence and genome of a Mucor circinelloides isolate from yogurt. Mbio. 5: e01390-14. PMID 25006230 DOI: 10.1128/Mbio.01390-14  0.773
2014 Roach KC, Feretzaki M, Sun S, Heitman J. Unisexual reproduction. Advances in Genetics. 85: 255-305. PMID 24880737 DOI: 10.1016/B978-0-12-800271-1.00005-6  0.824
2014 Janbon G, Ormerod KL, Paulet D, Byrnes EJ, Yadav V, Chatterjee G, Mullapudi N, Hon CC, Billmyre RB, Brunel F, Bahn YS, Chen W, Chen Y, Chow EW, Coppée JY, ... ... Heitman J, et al. Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation. Plos Genetics. 10: e1004261. PMID 24743168 DOI: 10.1371/Journal.Pgen.1004261  0.802
2014 Goodenough U, Heitman J. Origins of eukaryotic sexual reproduction. Cold Spring Harbor Perspectives in Biology. 6. PMID 24591519 DOI: 10.1101/Cshperspect.A016154  0.362
2014 Butts A, Koselny K, Chabrier-Roselló Y, Semighini CP, Brown JC, Wang X, Annadurai S, DiDone L, Tabroff J, Childers WE, Abou-Gharbia M, Wellington M, Cardenas ME, Madhani HD, Heitman J, et al. Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo. Mbio. 5: e00765-13. PMID 24520056 DOI: 10.1128/Mbio.00765-13  0.311
2014 Kingsbury JM, Sen ND, Maeda T, Heitman J, Cardenas ME. Endolysosomal membrane trafficking complexes drive nutrient-dependent TORC1 signaling to control cell growth in Saccharomyces cerevisiae. Genetics. 196: 1077-89. PMID 24514902 DOI: 10.1534/Genetics.114.161646  0.335
2014 Chen YL, Yu SJ, Huang HY, Chang YL, Lehman VN, Silao FG, Bigol UG, Bungay AA, Averette A, Heitman J. Calcineurin controls hyphal growth, virulence, and drug tolerance of Candida tropicalis. Eukaryotic Cell. 13: 844-54. PMID 24442892 DOI: 10.1128/Ec.00302-13  0.737
2014 Lee SC, Sun S, Heitman J. Unseen sex in ancient virgin fungi. The New Phytologist. 201: 3-5. PMID 24274789 DOI: 10.1111/Nph.12564  0.656
2014 Ormerod KL, Byrnes EJ, Wood IA, Lodge JK, Heitman J, Fraser JA. The H99 family tree: variation in the common laboratory reference strains of Cryptococcus neoformans var. grubii characterised through whole-genome sequencing Mycoses. 57: 69-70. DOI: 10.1111/Myc.12196  0.786
2013 Umen J, Heitman J. Evolution of sex: mating rituals of a pre-metazoan. Current Biology : Cb. 23: R1006-8. PMID 24262825 DOI: 10.1016/J.Cub.2013.10.009  0.338
2013 Feretzaki M, Heitman J. Unisexual reproduction drives evolution of eukaryotic microbial pathogens. Plos Pathogens. 9: e1003674. PMID 24204257 DOI: 10.1371/Journal.Ppat.1003674  0.764
2013 Billmyre RB, Calo S, Feretzaki M, Wang X, Heitman J. RNAi function, diversity, and loss in the fungal kingdom. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 21: 561-72. PMID 24173579 DOI: 10.1007/S10577-013-9388-2  0.807
2013 Kozubowski L, Yadav V, Chatterjee G, Sridhar S, Yamaguchi M, Kawamoto S, Bose I, Heitman J, Sanyal K. Ordered kinetochore assembly in the human-pathogenic basidiomycetous yeast Cryptococcus neoformans. Mbio. 4: e00614-13. PMID 24085781 DOI: 10.1128/Mbio.00614-13  0.793
2013 Ni M, Feretzaki M, Li W, Floyd-Averette A, Mieczkowski P, Dietrich FS, Heitman J. Unisexual and heterosexual meiotic reproduction generate aneuploidy and phenotypic diversity de novo in the yeast Cryptococcus neoformans. Plos Biology. 11: e1001653. PMID 24058295 DOI: 10.1371/Journal.Pbio.1001653  0.8
2013 Voelz K, Ma H, Phadke S, Byrnes EJ, Zhu P, Mueller O, Farrer RA, Henk DA, Lewit Y, Hsueh YP, Fisher MC, Idnurm A, Heitman J, May RC. Transmission of Hypervirulence traits via sexual reproduction within and between lineages of the human fungal pathogen cryptococcus gattii. Plos Genetics. 9: e1003771. PMID 24039607 DOI: 10.1371/Journal.Pgen.1003771  0.823
2013 Lee SC, Li A, Calo S, Heitman J. Calcineurin plays key roles in the dimorphic transition and virulence of the human pathogenic zygomycete Mucor circinelloides. Plos Pathogens. 9: e1003625. PMID 24039585 DOI: 10.1371/Journal.Ppat.1003625  0.601
2013 Feretzaki M, Heitman J. Genetic circuits that govern bisexual and unisexual reproduction in Cryptococcus neoformans. Plos Genetics. 9: e1003688. PMID 23966871 DOI: 10.1371/Journal.Pgen.1003688  0.779
2013 James TY, Sun S, Li W, Heitman J, Kuo HC, Lee YH, Asiegbu FO, Olson A. Polyporales genomes reveal the genetic architecture underlying tetrapolar and bipolar mating systems. Mycologia. 105: 1374-90. PMID 23928418 DOI: 10.3852/13-162  0.647
2013 Springer DJ, Saini D, Byrnes EJ, Heitman J, Frothingham R. Development of an aerosol model of Cryptococcus reveals humidity as an important factor affecting the viability of Cryptococcus during aerosolization. Plos One. 8: e69804. PMID 23894542 DOI: 10.1371/Journal.Pone.0069804  0.747
2013 Ravu RR, Chen YL, Jacob MR, Pan X, Agarwal AK, Khan SI, Heitman J, Clark AM, Li XC. Synthesis and antifungal activities of miltefosine analogs. Bioorganic & Medicinal Chemistry Letters. 23: 4828-31. PMID 23891181 DOI: 10.1055/S-0033-1348564  0.724
2013 Martin MD, Cappellini E, Samaniego JA, Zepeda ML, Campos PF, Seguin-Orlando A, Wales N, Orlando L, Ho SY, Dietrich FS, Mieczkowski PA, Heitman J, Willerslev E, Krogh A, Ristaino JB, et al. Reconstructing genome evolution in historic samples of the Irish potato famine pathogen. Nature Communications. 4: 2172. PMID 23863894 DOI: 10.1038/Ncomms3172  0.387
2013 Phadke SS, Feretzaki M, Heitman J. Unisexual reproduction enhances fungal competitiveness by promoting habitat exploration via hyphal growth and sporulation. Eukaryotic Cell. 12: 1155-9. PMID 23794511 DOI: 10.1128/Ec.00147-13  0.787
2013 Calo S, Billmyre RB, Heitman J. Generators of phenotypic diversity in the evolution of pathogenic microorganisms. Plos Pathogens. 9: e1003181. PMID 23555239 DOI: 10.1371/Journal.Ppat.1003181  0.766
2013 Guerreiro MA, Springer DJ, Rodrigues JA, Rusche LN, Findley K, Heitman J, Fonseca A. Molecular and genetic evidence for a tetrapolar mating system in the basidiomycetous yeast Kwoniella mangrovensis and two novel sibling species. Eukaryotic Cell. 12: 746-60. PMID 23524993 DOI: 10.1128/Ec.00065-13  0.814
2013 Ding C, Festa RA, Chen YL, Espart A, Palacios Ò, Espín J, Capdevila M, Atrian S, Heitman J, Thiele DJ. Cryptococcus neoformans copper detoxification machinery is critical for fungal virulence. Cell Host & Microbe. 13: 265-76. PMID 23498952 DOI: 10.1016/J.Chom.2013.02.002  0.686
2013 Chen YL, Lehman VN, Averette AF, Perfect JR, Heitman J. Posaconazole exhibits in vitro and in vivo synergistic antifungal activity with caspofungin or FK506 against Candida albicans. Plos One. 8: e57672. PMID 23472097 DOI: 10.1371/Journal.Pone.0057672  0.717
2013 Chen YL, Lehman VN, Lewit Y, Averette AF, Heitman J. Calcineurin governs thermotolerance and virulence of Cryptococcus gattii. G3 (Bethesda, Md.). 3: 527-39. PMID 23450261 DOI: 10.1534/G3.112.004242  0.731
2013 Wang X, Darwiche S, Heitman J. Sex-induced silencing operates during opposite-sex and unisexual reproduction in Cryptococcus neoformans. Genetics. 193: 1163-74. PMID 23378067 DOI: 10.1534/Genetics.113.149443  0.35
2013 Gioti A, Nystedt B, Li W, Xu J, Andersson A, Averette AF, Münch K, Wang X, Kappauf C, Kingsbury JM, Kraak B, Walker LA, Johansson HJ, Holm T, Lehtiö J, ... ... Heitman J, et al. Genomic insights into the atopic eczema-associated skin commensal yeast Malassezia sympodialis. Mbio. 4: e00572-12. PMID 23341551 DOI: 10.1128/Mbio.00572-12  0.529
2013 Li W, Sullivan TD, Walton E, Averette AF, Sakthikumar S, Cuomo CA, Klein BS, Heitman J. Identification of the mating-type (MAT) locus that controls sexual reproduction of Blastomyces dermatitidis. Eukaryotic Cell. 12: 109-17. PMID 23143684 DOI: 10.1128/Ec.00249-12  0.505
2013 Heitman J, Sun S, James TY. Evolution of fungal sexual reproduction. Mycologia. 105: 1-27. PMID 23099518 DOI: 10.3852/12-253  0.59
2012 Lee SC, Ristaino JB, Heitman J. Parallels in intercellular communication in oomycete and fungal pathogens of plants and humans. Plos Pathogens. 8: e1003028. PMID 23271965 DOI: 10.1371/Journal.Ppat.1003028  0.613
2012 Springer DJ, Phadke S, Billmyre B, Heitman J. Cryptococcus gattii, no longer an accidental pathogen? Current Fungal Infection Reports. 6: 245-256. PMID 23243480 DOI: 10.1007/S12281-012-0111-0  0.379
2012 Yang DH, Maeng S, Strain AK, Floyd A, Nielsen K, Heitman J, Bahn YS. Pleiotropic roles of the Msi1-like protein Msl1 in Cryptococcus neoformans. Eukaryotic Cell. 11: 1482-95. PMID 23042129 DOI: 10.1128/Ec.00261-12  0.747
2012 Lee SC, Phadke S, Sun S, Heitman J. Pseudohyphal growth of Cryptococcus neoformans is a reversible dimorphic transition in response to ammonium that requires Amt1 and Amt2 ammonium permeases. Eukaryotic Cell. 11: 1391-8. PMID 23002105 DOI: 10.1128/Ec.00242-12  0.686
2012 Zhang J, Silao FG, Bigol UG, Bungay AA, Nicolas MG, Heitman J, Chen YL. Calcineurin is required for pseudohyphal growth, virulence, and drug resistance in Candida lusitaniae. Plos One. 7: e44192. PMID 22952924 DOI: 10.1371/Journal.Pone.0044192  0.729
2012 Martinez DA, Oliver BG, Gräser Y, Goldberg JM, Li W, Martinez-Rossi NM, Monod M, Shelest E, Barton RC, Birch E, Brakhage AA, Chen Z, Gurr SJ, Heiman D, Heitman J, et al. Comparative genome analysis of Trichophyton rubrum and related dermatophytes reveals candidate genes involved in infection. Mbio. 3: e00259-12. PMID 22951933 DOI: 10.1128/Mbio.00259-12  0.524
2012 Sun S, Heitman J. Should Y stay or should Y go: the evolution of non-recombining sex chromosomes. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 34: 938-42. PMID 22948853 DOI: 10.1002/Bies.201200064  0.546
2012 Wang X, Wang P, Sun S, Darwiche S, Idnurm A, Heitman J. Transgene induced co-suppression during vegetative growth in Cryptococcus neoformans. Plos Genetics. 8: e1002885. PMID 22916030 DOI: 10.1371/Journal.Pgen.1002885  0.743
2012 Zhang J, Heitman J, Chen YL. Comparative analysis of calcineurin signaling between Candida dubliniensis and Candida albicans. Communicative & Integrative Biology. 5: 122-6. PMID 22808313 DOI: 10.4161/Cib.18833  0.756
2012 Kingsbury JM, Heitman J, Pinnell SR. Calcofluor white combination antifungal treatments for Trichophyton rubrum and Candida albicans. Plos One. 7: e39405. PMID 22792174 DOI: 10.1371/Journal.Pone.0039405  0.324
2012 Sun S, Hsueh YP, Heitman J. Gene conversion occurs within the mating-type locus of Cryptococcus neoformans during sexual reproduction. Plos Genetics. 8: e1002810. PMID 22792079 DOI: 10.1371/Journal.Pgen.1002810  0.709
2012 Floudas D, Binder M, Riley R, Barry K, Blanchette RA, Henrissat B, Martínez AT, Otillar R, Spatafora JW, Yadav JS, Aerts A, Benoit I, Boyd A, Carlson A, Copeland A, ... ... Heitman J, et al. The Paleozoic origin of enzymatic lignin decomposition reconstructed from 31 fungal genomes. Science (New York, N.Y.). 336: 1715-9. PMID 22745431 DOI: 10.1126/Science.1221748  0.795
2012 Saunders CW, Scheynius A, Heitman J. Malassezia fungi are specialized to live on skin and associated with dandruff, eczema, and other skin diseases. Plos Pathogens. 8: e1002701. PMID 22737067 DOI: 10.1371/Journal.Ppat.1002701  0.38
2012 Chen YL, Konieczka JH, Springer DJ, Bowen SE, Zhang J, Silao FG, Bungay AA, Bigol UG, Nicolas MG, Abraham SN, Thompson DA, Regev A, Heitman J. Convergent Evolution of Calcineurin Pathway Roles in Thermotolerance and Virulence in Candida glabrata. G3 (Bethesda, Md.). 2: 675-91. PMID 22690377 DOI: 10.1534/G3.112.002279  0.744
2012 Singh-Babak SD, Babak T, Diezmann S, Hill JA, Xie JL, Chen YL, Poutanen SM, Rennie RP, Heitman J, Cowen LE. Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata. Plos Pathogens. 8: e1002718. PMID 22615574 DOI: 10.1371/Journal.Ppat.1002718  0.781
2012 Geunes-Boyer S, Beers MF, Perfect JR, Heitman J, Wright JR. Surfactant protein D facilitates Cryptococcus neoformans infection. Infection and Immunity. 80: 2444-53. PMID 22547543 DOI: 10.1128/Iai.05613-11  0.322
2012 Lee SC, Heitman J. Function of Cryptococcus neoformans KAR7 (SEC66) in karyogamy during unisexual and opposite-sex mating. Eukaryotic Cell. 11: 783-94. PMID 22544906 DOI: 10.1128/Ec.00066-12  0.608
2012 Li W, Averette AF, Desnos-Ollivier M, Ni M, Dromer F, Heitman J. Genetic Diversity and Genomic Plasticity of Cryptococcus neoformans AD Hybrid Strains. G3 (Bethesda, Md.). 2: 83-97. PMID 22384385 DOI: 10.1534/G3.111.001255  0.474
2012 Morrow CA, Lee IR, Chow EW, Ormerod KL, Goldinger A, Byrnes EJ, Nielsen K, Heitman J, Schirra HJ, Fraser JA. A unique chromosomal rearrangement in the Cryptococcus neoformans var. grubii type strain enhances key phenotypes associated with virulence. Mbio. 3. PMID 22375073 DOI: 10.1128/Mbio.00310-11  0.834
2012 Findley K, Sun S, Fraser JA, Hsueh YP, Averette AF, Li W, Dietrich FS, Heitman J. Discovery of a modified tetrapolar sexual cycle in Cryptococcus amylolentus and the evolution of MAT in the Cryptococcus species complex. Plos Genetics. 8: e1002528. PMID 22359516 DOI: 10.1371/Journal.Pgen.1002528  0.823
2012 Bastidas RJ, Shertz CA, Lee SC, Heitman J, Cardenas ME. Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor. Eukaryotic Cell. 11: 270-81. PMID 22210828 DOI: 10.1128/Ec.05284-11  0.784
2012 Song MH, Lee JW, Kim MS, Yoon JK, White TC, Floyd A, Heitman J, Strain AK, Nielsen JN, Nielsen K, Bahn YS. A flucytosine-responsive Mbp1/Swi4-like protein, Mbs1, plays pleiotropic roles in antifungal drug resistance, stress response, and virulence of Cryptococcus neoformans. Eukaryotic Cell. 11: 53-67. PMID 22080454 DOI: 10.1128/Ec.05236-11  0.74
2012 Wang X, Li W, Sun S, Kozubowski L, Lee SC, Feretzaki M, Heitman J. Know your enemy: how to build and vanquish a global fungal scourge. Mycopathologia. 173: 295-301. PMID 21997858 DOI: 10.1007/S11046-011-9484-9  0.788
2012 Kozubowski L, Heitman J. Profiling a killer, the development of Cryptococcus neoformans. Fems Microbiology Reviews. 36: 78-94. PMID 21658085 DOI: 10.1111/J.1574-6976.2011.00286.X  0.751
2011 Semighini CP, Averette AF, Perfect JR, Heitman J. Deletion of Cryptococcus neoformans AIF ortholog promotes chromosome aneuploidy and fluconazole-resistance in a metacaspase-independent manner. Plos Pathogens. 7: e1002364. PMID 22114551 DOI: 10.1371/Journal.Ppat.1002364  0.386
2011 Aboobakar EF, Wang X, Heitman J, Kozubowski L. The C2 domain protein Cts1 functions in the calcineurin signaling circuit during high-temperature stress responses in Cryptococcus neoformans. Eukaryotic Cell. 10: 1714-23. PMID 22002655 DOI: 10.1128/Ec.05148-11  0.72
2011 Kozubowski L, Thompson JW, Cardenas ME, Moseley MA, Heitman J. Association of calcineurin with the COPI protein Sec28 and the COPII protein Sec13 revealed by quantitative proteomics. Plos One. 6: e25280. PMID 21984910 DOI: 10.1371/Journal.Pone.0025280  0.706
2011 Ni M, Feretzaki M, Sun S, Wang X, Heitman J. Sex in fungi. Annual Review of Genetics. 45: 405-30. PMID 21942368 DOI: 10.1146/Annurev-Genet-110410-132536  0.805
2011 Byrnes EJ, Li W, Ren P, Lewit Y, Voelz K, Fraser JA, Dietrich FS, May RC, Chaturvedi S, Chatuverdi S, Chaturvedi V, Chatuverdi V, Heitman J. A diverse population of Cryptococcus gattii molecular type VGIII in southern Californian HIV/AIDS patients. Plos Pathogens. 7: e1002205. PMID 21909264 DOI: 10.1371/Journal.Ppat.1002205  0.803
2011 Sun S, Heitman J. Is sex necessary? Bmc Biology. 9: 56. PMID 21880159 DOI: 10.1186/1741-7007-9-56  0.582
2011 Cheon SA, Jung KW, Chen YL, Heitman J, Bahn YS, Kang HA. Unique evolution of the UPR pathway with a novel bZIP transcription factor, Hxl1, for controlling pathogenicity of Cryptococcus neoformans. Plos Pathogens. 7: e1002177. PMID 21852949 DOI: 10.1371/Journal.Ppat.1002177  0.8
2011 McCulloh RJ, Phillips R, Perfect JR, Byrnes EJ, Heitman J, Dufort E. Cryptococcus gattii genotype VGI infection in New England. The Pediatric Infectious Disease Journal. 30: 1111-4. PMID 21814154 DOI: 10.1097/Inf.0B013E31822D14Fd  0.748
2011 Kozubowski L, Aboobakar EF, Cardenas ME, Heitman J. Calcineurin colocalizes with P-bodies and stress granules during thermal stress in Cryptococcus neoformans. Eukaryotic Cell. 10: 1396-402. PMID 21724937 DOI: 10.1128/Ec.05087-11  0.69
2011 Li CH, Cervantes M, Springer DJ, Boekhout T, Ruiz-Vazquez RM, Torres-Martinez SR, Heitman J, Lee SC. Sporangiospore size dimorphism is linked to virulence of Mucor circinelloides. Plos Pathogens. 7: e1002086. PMID 21698218 DOI: 10.1371/Journal.Ppat.1002086  0.577
2011 Byrnes EJ, Bartlett KH, Perfect JR, Heitman J. Cryptococcus gattii: an emerging fungal pathogen infecting humans and animals. Microbes and Infection / Institut Pasteur. 13: 895-907. PMID 21684347 DOI: 10.1016/J.Micinf.2011.05.009  0.765
2011 Chen YL, Brand A, Morrison EL, Silao FG, Bigol UG, Malbas FF, Nett JE, Andes DR, Solis NV, Filler SG, Averette A, Heitman J. Calcineurin controls drug tolerance, hyphal growth, and virulence in Candida dubliniensis. Eukaryotic Cell. 10: 803-19. PMID 21531874 DOI: 10.1128/Ec.00310-10  0.73
2011 Heitman J. Microbial Pathogens in the Fungal Kingdom. Fungal Biology Reviews. 25: 48-60. PMID 21528015 DOI: 10.1016/J.Fbr.2011.01.003  0.444
2011 D'Souza CA, Kronstad JW, Taylor G, Warren R, Yuen M, Hu G, Jung WH, Sham A, Kidd SE, Tangen K, Lee N, Zeilmaker T, Sawkins J, McVicker G, Shah S, ... ... Heitman J, et al. Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts. Mbio. 2: e00342-10. PMID 21304167 DOI: 10.1128/Mbio.00342-10  0.622
2011 Burmester A, Shelest E, Glöckner G, Heddergott C, Schindler S, Staib P, Heidel A, Felder M, Petzold A, Szafranski K, Feuermann M, Pedruzzi I, Priebe S, Groth M, Winkler R, ... ... Heitman J, et al. Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi. Genome Biology. 12: R7. PMID 21247460 DOI: 10.1186/Gb-2011-12-1-R7  0.535
2011 Sun S, Metin B, Findley K, Fonseca A, Heitman J. Validation of kwoniella heveanensis, teleomorph of the basidiomycetous yeast Cryptococcus heveanensis Mycotaxon. 116: 227-229. DOI: 10.5248/116.227  0.776
2011 Byrnes EJ, Li W, Ren P, Lewit Y, Voelz K, Fraser JA, Dietrich FS, May RC, Chaturvedi S, Chaturvedi V, Heitman J. Correction: A Diverse Population of Cryptococcus gattii Molecular Type VGIII in Southern Californian HIV/AIDS Patients Plos Pathogens. 7. DOI: 10.1371/annotation/a23709b0-8d67-4b57-aa05-d5d70d830724  0.754
2011 Gladieux P, Byrnes EJ, Aguileta G, Fisher MC, Heitman J, Giraud T. Epidemiology and evolution of fungal pathogens in plants and animals Genetics and Evolution of Infectious Diseases. 59-132. DOI: 10.1016/B978-0-12-384890-1.00004-2  0.729
2010 Gryganskyi AP, Lee SC, Litvintseva AP, Smith ME, Bonito G, Porter TM, Anishchenko IM, Heitman J, Vilgalys R. Structure, function, and phylogeny of the mating locus in the Rhizopus oryzae complex. Plos One. 5: e15273. PMID 21151560 DOI: 10.1371/Journal.Pone.0015273  0.595
2010 Wang X, Hsueh YP, Li W, Floyd A, Skalsky R, Heitman J. Sex-induced silencing defends the genome of Cryptococcus neoformans via RNAi. Genes & Development. 24: 2566-82. PMID 21078820 DOI: 10.1101/Gad.1970910  0.645
2010 Janbon G, Maeng S, Yang DH, Ko YJ, Jung KW, Moyrand F, Floyd A, Heitman J, Bahn YS. Characterizing the role of RNA silencing components in Cryptococcus neoformans. Fungal Genetics and Biology : Fg & B. 47: 1070-80. PMID 21067947 DOI: 10.1016/J.Fgb.2010.10.005  0.63
2010 Shertz CA, Bastidas RJ, Li W, Heitman J, Cardenas ME. Conservation, duplication, and loss of the Tor signaling pathway in the fungal kingdom. Bmc Genomics. 11: 510. PMID 20863387 DOI: 10.1186/1471-2164-11-510  0.778
2010 Xue C, Liu T, Chen L, Li W, Liu I, Kronstad JW, Seyfang A, Heitman J. Role of an expanded inositol transporter repertoire in Cryptococcus neoformans sexual reproduction and virulence. Mbio. 1. PMID 20689743 DOI: 10.1128/Mbio.00084-10  0.713
2010 Heitman J. Evolution of eukaryotic microbial pathogens via covert sexual reproduction. Cell Host & Microbe. 8: 86-99. PMID 20638645 DOI: 10.1016/J.Chom.2010.06.011  0.387
2010 Okagaki LH, Strain AK, Nielsen JN, Charlier C, Baltes NJ, Chrétien F, Heitman J, Dromer F, Nielsen K. Cryptococcal cell morphology affects host cell interactions and pathogenicity. Plos Pathogens. 6: e1000953. PMID 20585559 DOI: 10.1371/journal.ppat.1000953  0.802
2010 Kim MS, Ko YJ, Maeng S, Floyd A, Heitman J, Bahn YS. Comparative transcriptome analysis of the CO2 sensing pathway via differential expression of carbonic anhydrase in Cryptococcus neoformans. Genetics. 185: 1207-19. PMID 20516494 DOI: 10.1534/Genetics.110.118315  0.645
2010 Lee SC, Ni M, Li W, Shertz C, Heitman J. The evolution of sex: a perspective from the fungal kingdom. Microbiology and Molecular Biology Reviews : Mmbr. 74: 298-340. PMID 20508251 DOI: 10.1128/Mmbr.00005-10  0.617
2010 Metin B, Findley K, Heitman J. The mating type locus (MAT) and sexual reproduction of Cryptococcus heveanensis: insights into the evolution of sex and sex-determining chromosomal regions in fungi. Plos Genetics. 6: e1000961. PMID 20502678 DOI: 10.1371/Journal.Pgen.1000961  0.828
2010 Idnurm A, Heitman J. Ferrochelatase is a conserved downstream target of the blue light-sensing White collar complex in fungi. Microbiology (Reading, England). 156: 2393-407. PMID 20488877 DOI: 10.1099/Mic.0.039222-0  0.63
2010 Lin X, Jackson JC, Feretzaki M, Xue C, Heitman J. Transcription factors Mat2 and Znf2 operate cellular circuits orchestrating opposite- and same-sex mating in Cryptococcus neoformans. Plos Genetics. 6: e1000953. PMID 20485569 DOI: 10.1371/Journal.Pgen.1000953  0.821
2010 Lee SC, Corradi N, Doan S, Dietrich FS, Keeling PJ, Heitman J. Evolution of the sex-related locus and genomic features shared in microsporidia and fungi. Plos One. 5: e10539. PMID 20479876 DOI: 10.1371/Journal.Pone.0010539  0.607
2010 Byrnes EJ, Li W, Lewit Y, Ma H, Voelz K, Ren P, Carter DA, Chaturvedi V, Bildfell RJ, May RC, Heitman J. Emergence and pathogenicity of highly virulent Cryptococcus gattii genotypes in the northwest United States. Plos Pathogens. 6: e1000850. PMID 20421942 DOI: 10.1371/Journal.Ppat.1000850  0.784
2010 Rodriguez-Carres M, Findley K, Sun S, Dietrich FS, Heitman J. Morphological and genomic characterization of Filobasidiella depauperata: a homothallic sibling species of the pathogenic cryptococcus species complex. Plos One. 5: e9620. PMID 20224779 DOI: 10.1371/Journal.Pone.0009620  0.823
2010 Maeng S, Ko YJ, Kim GB, Jung KW, Floyd A, Heitman J, Bahn YS. Comparative transcriptome analysis reveals novel roles of the Ras and cyclic AMP signaling pathways in environmental stress response and antifungal drug sensitivity in Cryptococcus neoformans. Eukaryotic Cell. 9: 360-78. PMID 20097740 DOI: 10.1128/Ec.00309-09  0.623
2010 Kozubowski L, Heitman J. Septins enforce morphogenetic events during sexual reproduction and contribute to virulence of Cryptococcus neoformans. Molecular Microbiology. 75: 658-75. PMID 19943902 DOI: 10.1111/J.1365-2958.2009.06983.X  0.75
2010 Li W, Metin B, White TC, Heitman J. Organization and evolutionary trajectory of the mating type (MAT) locus in dermatophyte and dimorphic fungal pathogens. Eukaryotic Cell. 9: 46-58. PMID 19880755 DOI: 10.1128/Ec.00259-09  0.533
2010 Reedy JL, Filler SG, Heitman J. Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence. Fungal Genetics and Biology : Fg & B. 47: 107-16. PMID 19755168 DOI: 10.1016/J.Fgb.2009.09.002  0.775
2010 Chen YL, Kozubowski L, Cardenas ME, Heitman J. On the roles of calcineurin in fungal growth and pathogenesis Current Fungal Infection Reports. 4: 244-255. DOI: 10.1007/S12281-010-0027-5  0.748
2009 Byrnes EJ, Heitman J. Cryptococcus gattii outbreak expands into the Northwestern United States with fatal consequences. F1000 Biology Reports. 1. PMID 20150950 DOI: 10.3410/B1-62  0.761
2009 Lee SC, Weiss LM, Heitman J. Generation of genetic diversity in microsporidia via sexual reproduction and horizontal gene transfer. Communicative & Integrative Biology. 2: 414-7. PMID 19907704 DOI: 10.4161/Cib.2.5.8846  0.628
2009 Datta K, Bartlett KH, Baer R, Byrnes E, Galanis E, Heitman J, Hoang L, Leslie MJ, MacDougall L, Magill SS, Morshed MG, Marr KA. Spread of Cryptococcus gattii into Pacific Northwest region of the United States. Emerging Infectious Diseases. 15: 1185-91. PMID 19757550 DOI: 10.3201/Eid1508.081384  0.766
2009 Heitman J. Microbial genetics: Love the one you're with. Nature. 460: 807-8. PMID 19675638 DOI: 10.1038/460807A  0.314
2009 Velagapudi R, Hsueh YP, Geunes-Boyer S, Wright JR, Heitman J. Spores as infectious propagules of Cryptococcus neoformans. Infection and Immunity. 77: 4345-55. PMID 19620339 DOI: 10.1128/Iai.00542-09  0.63
2009 Ko YJ, Yu YM, Kim GB, Lee GW, Maeng PJ, Kim S, Floyd A, Heitman J, Bahn YS. Remodeling of global transcription patterns of Cryptococcus neoformans genes mediated by the stress-activated HOG signaling pathways. Eukaryotic Cell. 8: 1197-217. PMID 19542307 DOI: 10.1128/Ec.00120-09  0.631
2009 Byrnes EJ, Li W, Lewit Y, Perfect JR, Carter DA, Cox GM, Heitman J. First reported case of Cryptococcus gattii in the Southeastern USA: implications for travel-associated acquisition of an emerging pathogen. Plos One. 4: e5851. PMID 19516904 DOI: 10.1371/Journal.Pone.0005851  0.774
2009 Butler G, Rasmussen MD, Lin MF, Santos MA, Sakthikumar S, Munro CA, Rheinbay E, Grabherr M, Forche A, Reedy JL, Agrafioti I, Arnaud MB, Bates S, Brown AJ, Brunke S, ... ... Heitman J, et al. Evolution of pathogenicity and sexual reproduction in eight Candida genomes. Nature. 459: 657-62. PMID 19465905 DOI: 10.1038/Nature08064  0.827
2009 Geunes-Boyer S, Oliver TN, Janbon G, Lodge JK, Heitman J, Perfect JR, Wright JR. Surfactant protein D increases phagocytosis of hypocapsular Cryptococcus neoformans by murine macrophages and enhances fungal survival. Infection and Immunity. 77: 2783-94. PMID 19451250 DOI: 10.1128/Iai.00088-09  0.321
2009 Reedy JL, Floyd AM, Heitman J. Mechanistic plasticity of sexual reproduction and meiosis in the Candida pathogenic species complex. Current Biology : Cb. 19: 891-9. PMID 19446455 DOI: 10.1016/J.Cub.2009.04.058  0.775
2009 Sanz C, Rodríguez-Romero J, Idnurm A, Christie JM, Heitman J, Corrochano LM, Eslava AP. Phycomyces MADB interacts with MADA to form the primary photoreceptor complex for fungal phototropism. Proceedings of the National Academy of Sciences of the United States of America. 106: 7095-100. PMID 19380729 DOI: 10.1073/Pnas.0900879106  0.632
2009 Shapiro RS, Uppuluri P, Zaas AK, Collins C, Senn H, Perfect JR, Heitman J, Cowen LE. Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling. Current Biology : Cb. 19: 621-9. PMID 19327993 DOI: 10.1016/J.Cub.2009.03.017  0.603
2009 Hsueh YP, Xue C, Heitman J. A constitutively active GPCR governs morphogenic transitions in Cryptococcus neoformans. The Embo Journal. 28: 1220-33. PMID 19322200 DOI: 10.1038/Emboj.2009.68  0.731
2009 Pinchai N, Perfect BZ, Juvvadi PR, Fortwendel JR, Cramer RA, Asfaw YG, Heitman J, Perfect JR, Steinbach WJ. Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis. Eukaryotic Cell. 8: 511-9. PMID 19252123 DOI: 10.1128/Ec.00336-08  0.342
2009 Semighini CP, Heitman J. Dynamic duo takes down fungal villains. Proceedings of the National Academy of Sciences of the United States of America. 106: 2971-2. PMID 19251661 DOI: 10.1073/Pnas.0900801106  0.301
2009 Byrnes EJ, Bildfell RJ, Frank SA, Mitchell TG, Marr KA, Heitman J. Molecular evidence that the range of the Vancouver Island outbreak of Cryptococcus gattii infection has expanded into the Pacific Northwest in the United States. The Journal of Infectious Diseases. 199: 1081-6. PMID 19220140 DOI: 10.1086/597306  0.769
2009 Bastidas RJ, Heitman J, Cardenas ME. The protein kinase Tor1 regulates adhesin gene expression in Candida albicans. Plos Pathogens. 5: e1000294. PMID 19197361 DOI: 10.1371/Journal.Ppat.1000294  0.749
2009 Lin X, Patel S, Litvintseva AP, Floyd A, Mitchell TG, Heitman J. Diploids in the Cryptococcus neoformans serotype A population homozygous for the alpha mating type originate via unisexual mating. Plos Pathogens. 5: e1000283. PMID 19180236 DOI: 10.1371/Journal.Ppat.1000283  0.56
2009 Kozubowski L, Lee SC, Heitman J. Signalling pathways in the pathogenesis of Cryptococcus. Cellular Microbiology. 11: 370-80. PMID 19170685 DOI: 10.1111/J.1462-5822.2008.01273.X  0.762
2009 Idnurm A, Walton FJ, Floyd A, Reedy JL, Heitman J. Identification of ENA1 as a virulence gene of the human pathogenic fungus Cryptococcus neoformans through signature-tagged insertional mutagenesis. Eukaryotic Cell. 8: 315-26. PMID 19151325 DOI: 10.1128/Ec.00375-08  0.814
2009 Findley K, Rodriguez-Carres M, Metin B, Kroiss J, Fonseca A, Vilgalys R, Heitman J. Phylogeny and phenotypic characterization of pathogenic Cryptococcus species and closely related saprobic taxa in the Tremellales. Eukaryotic Cell. 8: 353-61. PMID 19151324 DOI: 10.1128/Ec.00373-08  0.811
2009 Byrnes EJ, Bildfell RJ, Dearing PL, Valentine BA, Heitman J. Cryptococcus gattii with bimorphic colony types in a dog in western Oregon: additional evidence for expansion of the Vancouver Island outbreak. Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 21: 133-6. PMID 19139515 DOI: 10.1177/104063870902100122  0.761
2009 Bastidas RJ, Heitman J. Trimorphic stepping stones pave the way to fungal virulence. Proceedings of the National Academy of Sciences of the United States of America. 106: 351-2. PMID 19129500 DOI: 10.1073/Pnas.0811994106  0.743
2009 Jain N, Li L, Hsueh YP, Guerrero A, Heitman J, Goldman DL, Fries BC. Loss of allergen 1 confers a hypervirulent phenotype that resembles mucoid switch variants of Cryptococcus neoformans. Infection and Immunity. 77: 128-40. PMID 18955480 DOI: 10.1128/Iai.01079-08  0.615
2008 Lee SC, Corradi N, Byrnes EJ, Torres-Martinez S, Dietrich FS, Keeling PJ, Heitman J. Microsporidia evolved from ancestral sexual fungi. Current Biology : Cb. 18: 1675-9. PMID 18976912 DOI: 10.1016/J.Cub.2008.09.030  0.821
2008 Hsueh YP, Heitman J. Orchestration of sexual reproduction and virulence by the fungal mating-type locus. Current Opinion in Microbiology. 11: 517-24. PMID 18935978 DOI: 10.1016/J.Mib.2008.09.014  0.603
2008 Xue C, Hsueh YP, Heitman J. Magnificent seven: roles of G protein-coupled receptors in extracellular sensing in fungi. Fems Microbiology Reviews. 32: 1010-32. PMID 18811658 DOI: 10.1111/J.1574-6976.2008.00131.X  0.714
2008 Xue C, Hsueh YP, Chen L, Heitman J. The RGS protein Crg2 regulates both pheromone and cAMP signalling in Cryptococcus neoformans. Molecular Microbiology. 70: 379-95. PMID 18761692 DOI: 10.1111/J.1365-2958.2008.06417.X  0.724
2008 Hsueh YP, Fraser JA, Heitman J. Transitions in sexuality: recapitulation of an ancestral tri- and tetrapolar mating system in Cryptococcus neoformans. Eukaryotic Cell. 7: 1847-55. PMID 18723606 DOI: 10.1128/Ec.00271-08  0.717
2008 Bastidas RJ, Reedy JL, Morales-Johansson H, Heitman J, Cardenas ME. Signaling cascades as drug targets in model and pathogenic fungi. Current Opinion in Investigational Drugs (London, England : 2000). 9: 856-64. PMID 18666033  0.803
2008 Bui T, Lin X, Malik R, Heitman J, Carter D. Isolates of Cryptococcus neoformans from infected animals reveal genetic exchange in unisexual, alpha mating type populations. Eukaryotic Cell. 7: 1771-80. PMID 18552280 DOI: 10.1128/Ec.00097-08  0.575
2008 Cramer RA, Perfect BZ, Pinchai N, Park S, Perlin DS, Asfaw YG, Heitman J, Perfect JR, Steinbach WJ. Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus. Eukaryotic Cell. 7: 1085-97. PMID 18456861 DOI: 10.1128/Ec.00086-08  0.405
2008 Rutherford JC, Chua G, Hughes T, Cardenas ME, Heitman J. A Mep2-dependent transcriptional profile links permease function to gene expression during pseudohyphal growth in Saccharomyces cerevisiae. Molecular Biology of the Cell. 19: 3028-39. PMID 18434596 DOI: 10.1091/Mbc.E08-01-0033  0.33
2008 Lin X, Nielsen K, Patel S, Heitman J. Impact of mating type, serotype, and ploidy on the virulence of Cryptococcus neoformans. Infection and Immunity. 76: 2923-38. PMID 18426889 DOI: 10.1128/Iai.00168-08  0.701
2008 Idnurm A, Walton FJ, Floyd A, Heitman J. Identification of the sex genes in an early diverged fungus. Nature. 451: 193-6. PMID 18185588 DOI: 10.1038/Nature06453  0.656
2008 Uppuluri P, Nett J, Heitman J, Andes D. Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms. Antimicrobial Agents and Chemotherapy. 52: 1127-32. PMID 18180354 DOI: 10.1128/Aac.01397-07  0.357
2008 Teichert S, Rutherford JC, Wottawa M, Heitman J, Tudzynski B. Impact of ammonium permeases mepA, mepB, and mepC on nitrogen-regulated secondary metabolism in Fusarium fujikuroi. Eukaryotic Cell. 7: 187-201. PMID 18083831 DOI: 10.1128/Ec.00351-07  0.324
2008 Rutherford JC, Lin X, Nielsen K, Heitman J. Amt2 permease is required to induce ammonium-responsive invasive growth and mating in Cryptococcus neoformans. Eukaryotic Cell. 7: 237-46. PMID 18055915 DOI: 10.1128/Ec.00079-07  0.702
2008 Heitman J, Howlett B. Fungal horizons: the Asilomar Fungal Genetics Conference 2007 Fungal Genetics and Biology : Fg & B. 45: 77-83. PMID 17977033 DOI: 10.1016/J.Fgb.2007.09.009  0.329
2008 Baker SE, Thykaer J, Adney WS, Brettin TS, Brockman FJ, D'haeseleer P, Martinez AD, Miller RM, Rokhsar DS, Schadt CW, Torok T, Tuskan G, Bennett J, Berka RM, Briggs SP, ... Heitman J, et al. Fungal genome sequencing and bioenergy Fungal Biology Reviews. 22: 1-5. DOI: 10.1016/J.Fbr.2008.03.001  0.323
2007 Reedy JL, Bastidas RJ, Heitman J. The virulence of human pathogenic fungi: notes from the South of France. Cell Host & Microbe. 2: 77-83. PMID 18005722 DOI: 10.1016/J.Chom.2007.07.004  0.8
2007 Xue C, Tada Y, Dong X, Heitman J. The human fungal pathogen Cryptococcus can complete its sexual cycle during a pathogenic association with plants. Cell Host & Microbe. 1: 263-73. PMID 18005707 DOI: 10.1016/J.Chom.2007.05.005  0.663
2007 Lin X, Litvintseva AP, Nielsen K, Patel S, Floyd A, Mitchell TG, Heitman J. alpha AD alpha hybrids of Cryptococcus neoformans: evidence of same-sex mating in nature and hybrid fitness. Plos Genetics. 3: 1975-90. PMID 17953489 DOI: 10.1371/Journal.Pgen.0030186  0.676
2007 Bahn YS, Geunes-Boyer S, Heitman J. Ssk2 mitogen-activated protein kinase kinase kinase governs divergent patterns of the stress-activated Hog1 signaling pathway in Cryptococcus neoformans. Eukaryotic Cell. 6: 2278-89. PMID 17951522 DOI: 10.1128/Ec.00349-07  0.628
2007 Litvintseva AP, Lin X, Templeton I, Heitman J, Mitchell TG. Many globally isolated AD hybrid strains of Cryptococcus neoformans originated in Africa. Plos Pathogens. 3: e114. PMID 17708680 DOI: 10.1371/Journal.Ppat.0030114  0.545
2007 Onyewu C, Eads E, Schell WA, Perfect JR, Ullmann Y, Kaufman G, Horwitz BA, Berdicevsky I, Heitman J. Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model. Antimicrobial Agents and Chemotherapy. 51: 3743-6. PMID 17664323 DOI: 10.1128/Aac.00492-07  0.768
2007 Upton A, Fraser JA, Kidd SE, Bretz C, Bartlett KH, Heitman J, Marr KA. First contemporary case of human infection with Cryptococcus gattii in Puget Sound: evidence for spread of the Vancouver Island outbreak. Journal of Clinical Microbiology. 45: 3086-8. PMID 17596366 DOI: 10.1128/Jcm.00593-07  0.546
2007 Hsueh YP, Xue C, Heitman J. G protein signaling governing cell fate decisions involves opposing Galpha subunits in Cryptococcus neoformans. Molecular Biology of the Cell. 18: 3237-49. PMID 17581859 DOI: 10.1091/Mbc.E07-02-0133  0.732
2007 Valdivia RH, Heitman J. Endosymbiosis: the evil within. Current Biology : Cb. 17: R408-10. PMID 17550764 DOI: 10.1016/J.Cub.2007.04.001  0.372
2007 Steinbach WJ, Reedy JL, Cramer RA, Perfect JR, Heitman J. Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections. Nature Reviews. Microbiology. 5: 418-30. PMID 17505522 DOI: 10.1038/Nrmicro1680  0.741
2007 Steinbach WJ, Cramer RA, Perfect BZ, Henn C, Nielsen K, Heitman J, Perfect JR. Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus. Antimicrobial Agents and Chemotherapy. 51: 2979-81. PMID 17502415 DOI: 10.1128/Aac.01394-06  0.57
2007 Fan W, Idnurm A, Breger J, Mylonakis E, Heitman J. Eca1, a sarcoplasmic/endoplasmic reticulum Ca2+-ATPase, is involved in stress tolerance and virulence in Cryptococcus neoformans. Infection and Immunity. 75: 3394-405. PMID 17502401 DOI: 10.1128/Iai.01977-06  0.636
2007 Nielsen K, De Obaldia AL, Heitman J. Cryptococcus neoformans mates on pigeon guano: implications for the realized ecological niche and globalization. Eukaryotic Cell. 6: 949-59. PMID 17449657 DOI: 10.1128/Ec.00097-07  0.643
2007 Nielsen K, Heitman J. Sex and virulence of human pathogenic fungi. Advances in Genetics. 57: 143-73. PMID 17352904 DOI: 10.1016/S0065-2660(06)57004-X  0.653
2007 Fraser JA, Stajich JE, Tarcha EJ, Cole GT, Inglis DO, Sil A, Heitman J. Evolution of the mating type locus: insights gained from the dimorphic primary fungal pathogens Histoplasma capsulatum, Coccidioides immitis, and Coccidioides posadasii. Eukaryotic Cell. 6: 622-9. PMID 17337636 DOI: 10.1128/Ec.00018-07  0.645
2007 Howlett BJ, Idnurm A, Heitman J. Fungal Pathogenesis: Gene Clusters Unveiled as Secrets within the Ustilago maydis Code Current Biology. 17: R87-R90. PMID 17276906 DOI: 10.1016/J.Cub.2006.11.047  0.624
2007 Hicks JK, Heitman J. Divergence of protein kinase A catalytic subunits in Cryptococcus neoformans and Cryptococcus gattii illustrates evolutionary reconfiguration of a signaling cascade Eukaryotic Cell. 6: 413-420. PMID 17189488 DOI: 10.1128/Ec.00213-06  0.421
2007 Yan Z, Hull CM, Sun S, Heitman J, Xu J. The mating type-specific homeodomain genes SXI1 alpha and SXI2a coordinately control uniparental mitochondrial inheritance in Cryptococcus neoformans. Current Genetics. 51: 187-95. PMID 17186242 DOI: 10.1007/S00294-006-0115-9  0.729
2007 Bahn YS, Xue C, Idnurm A, Rutherford JC, Heitman J, Cardenas ME. Sensing the environment: lessons from fungi. Nature Reviews. Microbiology. 5: 57-69. PMID 17170747 DOI: 10.1038/Nrmicro1578  0.793
2007 Idnurm A, Giles SS, Perfect JR, Heitman J. Peroxisome function regulates growth on glucose in the basidiomycete fungus Cryptococcus neoformans. Eukaryotic Cell. 6: 60-72. PMID 17041184 DOI: 10.1128/Ec.00214-06  0.652
2007 Yu H, Seo J, Han K, Yun S, Lee Y, Ka K, Chang J, Ryu S, Yoon K, Bak W, Ka K, Park J, Oh D, Cheon W, Yoon K, ... ... Heitman J, et al. Abstracts of Presentations at the 2007 Spring Meeting of the Korean Society of Mycology at the Chonnam National University, Gwangju, Korea, May 4. Mycobiology. 35: 103-116. DOI: 10.1080/12298093.2007.12016041  0.512
2006 Lin X, Huang JC, Mitchell TG, Heitman J. Virulence attributes and hyphal growth of C. neoformans are quantitative traits and the MATalpha allele enhances filamentation. Plos Genetics. 2: e187. PMID 17112316 DOI: 10.1371/Journal.Pgen.0020187  0.581
2006 Hsueh YP, Idnurm A, Heitman J. Recombination hotspots flank the Cryptococcus mating-type locus: implications for the evolution of a fungal sex chromosome. Plos Genetics. 2: e184. PMID 17083277 DOI: 10.1371/Journal.Pgen.0020184  0.736
2006 Heitman J. Sexual reproduction and the evolution of microbial pathogens. Current Biology : Cb. 16: R711-25. PMID 16950098 DOI: 10.1016/J.Cub.2006.07.064  0.385
2006 Onyewu C, Afshari NA, Heitman J. Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy. Antimicrobial Agents and Chemotherapy. 50: 3963-5. PMID 16923949 DOI: 10.1128/Aac.00393-06  0.784
2006 Steinbach WJ, Cramer RA, Perfect BZ, Asfaw YG, Sauer TC, Najvar LK, Kirkpatrick WR, Patterson TF, Benjamin DK, Heitman J, Perfect JR. Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus. Eukaryotic Cell. 5: 1091-103. PMID 16835453 DOI: 10.1128/Ec.00139-06  0.392
2006 Harashima T, Anderson S, Yates JR, Heitman J. The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2. Molecular Cell. 22: 819-830. PMID 16793550 DOI: 10.1016/J.Molcel.2006.05.011  0.305
2006 Walton FJ, Heitman J, Idnurm A. Conserved elements of the RAM signaling pathway establish cell polarity in the basidiomycete Cryptococcus neoformans in a divergent fashion from other fungi. Molecular Biology of the Cell. 17: 3768-80. PMID 16775005 DOI: 10.1091/Mbc.E06-02-0125  0.662
2006 Lin X, Heitman J. The biology of the Cryptococcus neoformans species complex. Annual Review of Microbiology. 60: 69-105. PMID 16704346 DOI: 10.1146/Annurev.Micro.60.080805.142102  0.591
2006 Fraser JA, Lim SM, Diezmann S, Wenink EC, Arndt CG, Cox GM, Dietrich FS, Heitman J. Yeast diversity sampling on the San Juan Islands reveals no evidence for the spread of the Vancouver Island Cryptococcus gattii outbreak to this locale. Fems Yeast Research. 6: 620-4. PMID 16696658 DOI: 10.1111/J.1567-1364.2006.00075.X  0.574
2006 Bahn YS, Kojima K, Cox GM, Heitman J. A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans. Molecular Biology of the Cell. 17: 3122-35. PMID 16672377 DOI: 10.1091/Mbc.E06-02-0113  0.623
2006 Reedy JL, Husain S, Ison M, Pruett TL, Singh N, Heitman J. Immunotherapy with tacrolimus (FK506) does not select for resistance to calcineurin inhibitors in Candida albicans isolates from liver transplant patients. Antimicrobial Agents and Chemotherapy. 50: 1573-7. PMID 16569889 DOI: 10.1128/Aac.50.4.1573-1577.2006  0.711
2006 Idnurm A, Rodríguez-Romero J, Corrochano LM, Sanz C, Iturriaga EA, Eslava AP, Heitman J. The Phycomyces madA gene encodes a blue-light photoreceptor for phototropism and other light responses Proceedings of the National Academy of Sciences of the United States of America. 103: 4546-4551. PMID 16537433 DOI: 10.1073/Pnas.0600633103  0.619
2006 Kojima K, Bahn YS, Heitman J. Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans. Microbiology (Reading, England). 152: 591-604. PMID 16514140 DOI: 10.1099/Mic.0.28571-0  0.639
2006 Xue C, Bahn YS, Cox GM, Heitman J. G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans. Molecular Biology of the Cell. 17: 667-79. PMID 16291861 DOI: 10.1091/Mbc.E05-07-0699  0.733
2006 Idnurm A, Heitman J. Photosensing fungi: phytochrome in the spotlight. Current Biology : Cb. 15: R829-32. PMID 16243020 DOI: 10.1016/J.Cub.2005.10.001  0.602
2005 Hicks JK, Bahn YS, Heitman J. Pde1 phosphodiesterase modulates cyclic AMP levels through a protein kinase A-mediated negative feedback loop in Cryptococcus neoformans. Eukaryotic Cell. 4: 1971-81. PMID 16339715 DOI: 10.1128/Ec.4.12.1971-1981.2005  0.614
2005 Gugnani HC, Mitchell TG, Litvintseva AP, Lengeler KB, Heitman J, Kumar A, Basu S, Paliwal-Joshi A. Isolation of Cryptococcus gattii and Cryptococcus neoformans var. grubii from the flowers and bark of Eucalyptus trees in India Medical Mycology. 43: 565-569. PMID 16323312 DOI: 10.1080/13693780500160785  0.313
2005 Bahn YS, Cox GM, Perfect JR, Heitman J. Carbonic anhydrase and CO2 sensing during Cryptococcus neoformans growth, differentiation, and virulence. Current Biology : Cb. 15: 2013-20. PMID 16303560 DOI: 10.1016/J.Cub.2005.09.047  0.592
2005 Tang RJ, Breger J, Idnurm A, Gerik KJ, Lodge JK, Heitman J, Calderwood SB, Mylonakis E. Cryptococcus neoformans gene involved in mammalian pathogenesis identified by a Caenorhabditis elegans progeny-based approach. Infection and Immunity. 73: 8219-25. PMID 16299318 DOI: 10.1128/Iai.73.12.8219-8225.2005  0.657
2005 Fraser JA, Giles SS, Wenink EC, Geunes-Boyer SG, Wright JR, Diezmann S, Allen A, Stajich JE, Dietrich FS, Perfect JR, Heitman J. Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak. Nature. 437: 1360-4. PMID 16222245 DOI: 10.1038/Nature04220  0.623
2005 Lin X, Heitman J. Chlamydospore formation during hyphal growth in Cryptococcus neoformans. Eukaryotic Cell. 4: 1746-54. PMID 16215181 DOI: 10.1128/Ec.4.10.1746-1754.2005  0.57
2005 Heitman J. Cell biology. A fungal Achilles' heel. Science (New York, N.Y.). 309: 2175-6. PMID 16195450 DOI: 10.1126/Science.1119321  0.352
2005 Fraser JA, Heitman J. Chromosomal sex-determining regions in animals, plants and fungi. Current Opinion in Genetics & Development. 15: 645-51. PMID 16182521 DOI: 10.1016/J.Gde.2005.09.002  0.589
2005 Fox DS, Heitman J. Calcineurin-binding protein Cbp1 directs the specificity of calcineurin-dependent hyphal elongation during mating in Cryptococcus neoformans. Eukaryotic Cell. 4: 1526-38. PMID 16151246 DOI: 10.1128/Ec.4.9.1526-1538.2005  0.39
2005 Idnurm A, Bahn YS, Nielsen K, Lin X, Fraser JA, Heitman J. Deciphering the model pathogenic fungus Cryptococcus neoformans. Nature Reviews. Microbiology. 3: 753-64. PMID 16132036 DOI: 10.1038/Nrmicro1245  0.826
2005 Blankenship JR, Heitman J. Calcineurin is required for Candida albicans to survive calcium stress in serum. Infection and Immunity. 73: 5767-74. PMID 16113294 DOI: 10.1128/Iai.73.9.5767-5774.2005  0.704
2005 Walton FJ, Idnurm A, Heitman J. Novel gene functions required for melanization of the human pathogen Cryptococcus neoformans. Molecular Microbiology. 57: 1381-96. PMID 16102007 DOI: 10.1111/J.1365-2958.2005.04779.X  0.68
2005 Fan W, Kraus PR, Boily MJ, Heitman J. Cryptococcus neoformans gene expression during murine macrophage infection. Eukaryotic Cell. 4: 1420-33. PMID 16087747 DOI: 10.1128/Ec.4.8.1420-1433.2005  0.393
2005 Campbell LT, Fraser JA, Nichols CB, Dietrich FS, Carter D, Heitman J. Clinical and environmental isolates of Cryptococcus gattii from Australia that retain sexual fecundity. Eukaryotic Cell. 4: 1410-9. PMID 16087746 DOI: 10.1128/Ec.4.8.1410-1419.2005  0.643
2005 Campbell LT, Currie BJ, Krockenberger M, Malik R, Meyer W, Heitman J, Carter D. Clonality and recombination in genetically differentiated subgroups of Cryptococcus gattii. Eukaryotic Cell. 4: 1403-9. PMID 16087745 DOI: 10.1128/Ec.4.8.1403-1409.2005  0.387
2005 Nielsen K, Cox GM, Litvintseva AP, Mylonakis E, Malliaris SD, Benjamin DK, Giles SS, Mitchell TG, Casadevall A, Perfect JR, Heitman J. Cryptococcus neoformans {alpha} strains preferentially disseminate to the central nervous system during coinfection. Infection and Immunity. 73: 4922-33. PMID 16041006 DOI: 10.1128/Iai.73.8.4922-4933.2005  0.592
2005 Wang P, Heitman J. The cyclophilins. Genome Biology. 6: 226. PMID 15998457 DOI: 10.1186/gb-2005-6-7-226  0.3
2005 Mylonakis E, Moreno R, El Khoury JB, Idnurm A, Heitman J, Calderwood SB, Ausubel FM, Diener A. Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis. Infection and Immunity. 73: 3842-50. PMID 15972469 DOI: 10.1128/Iai.73.7.3842-3850.2005  0.648
2005 Nielsen K, Marra RE, Hagen F, Boekhout T, Mitchell TG, Cox GM, Heitman J. Interaction between genetic background and the mating-type locus in Cryptococcus neoformans virulence potential. Genetics. 171: 975-83. PMID 15965241 DOI: 10.1534/Genetics.105.045039  0.641
2005 Kraus PR, Nichols CB, Heitman J. Calcium- and calcineurin-independent roles for calmodulin in Cryptococcus neoformans morphogenesis and high-temperature growth. Eukaryotic Cell. 4: 1079-87. PMID 15947200 DOI: 10.1128/Ec.4.6.1079-1087.2005  0.364
2005 Lin X, Hull CM, Heitman J. Sexual reproduction between partners of the same mating type in Cryptococcus neoformans. Nature. 434: 1017-21. PMID 15846346 DOI: 10.1038/Nature03448  0.703
2005 Idnurm A, Heitman J. Light controls growth and development via a conserved pathway in the fungal kingdom. Plos Biology. 3: e95. PMID 15760278 DOI: 10.1371/Journal.Pbio.0030095  0.65
2005 Hull CM, Boily MJ, Heitman J. Sex-specific homeodomain proteins Sxi1alpha and Sxi2a coordinately regulate sexual development in Cryptococcus neoformans. Eukaryotic Cell. 4: 526-35. PMID 15755915 DOI: 10.1128/Ec.4.3.526-535.2005  0.603
2005 Bahn YS, Kojima K, Cox GM, Heitman J. Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans. Molecular Biology of the Cell. 16: 2285-300. PMID 15728721 DOI: 10.1091/Mbc.E04-11-0987  0.643
2005 Fraser JA, Huang JC, Pukkila-Worley R, Alspaugh JA, Mitchell TG, Heitman J. Chromosomal translocation and segmental duplication in Cryptococcus neoformans. Eukaryotic Cell. 4: 401-6. PMID 15701802 DOI: 10.1128/Ec.4.2.401-406.2005  0.564
2005 Loftus BJ, Fung E, Roncaglia P, Rowley D, Amedeo P, Bruno D, Vamathevan J, Miranda M, Anderson IJ, Fraser JA, Allen JE, Bosdet IE, Brent MR, Chiu R, Doering TL, ... ... Heitman J, et al. The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. Science (New York, N.Y.). 307: 1321-4. PMID 15653466 DOI: 10.1126/Science.1103773  0.621
2005 Arévalo-Rodríguez M, Heitman J. Cyclophilin A is localized to the nucleus and controls meiosis in Saccharomyces cerevisiae. Eukaryotic Cell. 4: 17-29. PMID 15643056 DOI: 10.1128/Ec.4.1.17-29.2005  0.342
2005 Blankenship JR, Singh N, Alexander BD, Heitman J. Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens. Journal of Clinical Microbiology. 43: 464-7. PMID 15635017 DOI: 10.1128/Jcm.43.1.464-467.2005  0.684
2004 Bahn YS, Hicks JK, Giles SS, Cox GM, Heitman J. Adenylyl cyclase-associated protein Aca1 regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMP-protein kinase A cascade. Eukaryotic Cell. 3: 1476-91. PMID 15590822 DOI: 10.1128/Ec.3.6.1476-1491.2004  0.637
2004 Onyewu C, Wormley FL, Perfect JR, Heitman J. The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans. Infection and Immunity. 72: 7330-3. PMID 15557662 DOI: 10.1128/Iai.72.12.7330-7333.2004  0.792
2004 Fraser JA, Diezmann S, Subaran RL, Allen A, Lengeler KB, Dietrich FS, Heitman J. Convergent evolution of chromosomal sex-determining regions in the animal and fungal kingdoms. Plos Biology. 2: e384. PMID 15538538 DOI: 10.1371/Journal.Pbio.0020384  0.589
2004 Wang P, Cox GM, Heitman J. A Sch9 protein kinase homologue controlling virulence independently of the cAMP pathway in Cryptococcus neoformans. Current Genetics. 46: 247-55. PMID 15503029 DOI: 10.1007/S00294-004-0529-1  0.446
2004 Arévalo-Rodríguez M, Pan X, Boeke JD, Heitman J. FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation. Eukaryotic Cell. 3: 1287-96. PMID 15470257 DOI: 10.1128/Ec.3.5.1287-1296.2004  0.622
2004 Kraus PR, Boily MJ, Giles SS, Stajich JE, Allen A, Cox GM, Dietrich FS, Perfect JR, Heitman J. Identification of Cryptococcus neoformans temperature-regulated genes with a genomic-DNA microarray. Eukaryotic Cell. 3: 1249-60. PMID 15470254 DOI: 10.1128/Ec.3.5.1249-1260.2004  0.381
2004 Mylonakis E, Idnurm A, Moreno R, El Khoury J, Rottman JB, Ausubel FM, Heitman J, Calderwood SB. Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals. Molecular Microbiology. 54: 407-19. PMID 15469513 DOI: 10.1111/J.1365-2958.2004.04310.X  0.673
2004 Yan Z, Hull CM, Heitman J, Sun S, Xu J. SXI1alpha controls uniparental mitochondrial inheritance in Cryptococcus neoformans. Current Biology : Cb. 14: R743-4. PMID 15380081 DOI: 10.1016/J.Cub.2004.09.008  0.755
2004 Arevalo-Rodriguez M, Wu X, Hanes SD, Heitman J. Prolyl isomerases in yeast. Frontiers in Bioscience : a Journal and Virtual Library. 9: 2420-46. PMID 15353296 DOI: 10.2741/1405  0.349
2004 Toffaletti DL, Nielsen K, Dietrich F, Heitman J, Perfect JR. Cryptococcus neoformans mitochondrial genomes from serotype A and D strains do not influence virulence. Current Genetics. 46: 193-204. PMID 15309505 DOI: 10.1007/S00294-004-0521-9  0.605
2004 Nichols CB, Fraser JA, Heitman J. PAK kinases Ste20 and Pak1 govern cell polarity at different stages of mating in Cryptococcus neoformans. Molecular Biology of the Cell. 15: 4476-89. PMID 15282344 DOI: 10.1091/Mbc.E04-05-0370  0.569
2004 Marra RE, Huang JC, Fung E, Nielsen K, Heitman J, Vilgalys R, Mitchell TG. A genetic linkage map of Cryptococcus neoformans variety neoformans serotype D (Filobasidiella neoformans). Genetics. 167: 619-31. PMID 15238516 DOI: 10.1534/Genetics.103.023408  0.591
2004 Hull CM, Cox GM, Heitman J. The alpha-specific cell identity factor Sxi1alpha is not required for virulence of Cryptococcus neoformans. Infection and Immunity. 72: 3643-5. PMID 15155676 DOI: 10.1128/Iai.72.6.3643-3645.2004  0.557
2004 D'Souza CA, Hagen F, Boekhout T, Cox GM, Heitman J. Investigation of the basis of virulence in serotype A strains of Cryptococcus neoformans from apparently immunocompetent individuals. Current Genetics. 46: 92-102. PMID 15150669 DOI: 10.1007/S00294-004-0511-Y  0.346
2004 Steinbach WJ, Schell WA, Blankenship JR, Onyewu C, Heitman J, Perfect JR. In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus. Antimicrobial Agents and Chemotherapy. 48: 1664-9. PMID 15105118 DOI: 10.1128/Aac.48.5.1664-1669.2004  0.786
2004 Singh N, Heitman J. Antifungal attributes of immunosuppressive agents: new paradigms in management and elucidating the pathophysiologic basis of opportunistic mycoses in organ transplant recipients. Transplantation. 77: 795-800. PMID 15077015 DOI: 10.1097/01.Tp.0000117252.75651.D6  0.322
2004 Idnurm A, Reedy JL, Nussbaum JC, Heitman J. Cryptococcus neoformans virulence gene discovery through insertional mutagenesis. Eukaryotic Cell. 3: 420-9. PMID 15075272 DOI: 10.1128/Ec.3.2.420-429.2004  0.809
2004 Apidianakis Y, Rahme LG, Heitman J, Ausubel FM, Calderwood SB, Mylonakis E. Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response. Eukaryotic Cell. 3: 413-9. PMID 15075271 DOI: 10.1128/Ec.3.2.413-419.2004  0.353
2004 Aramburu J, Heitman J, Crabtree GR. Calcineurin: a central controller of signalling in eukaryotes. Embo Reports. 5: 343-8. PMID 15060569 DOI: 10.1038/Sj.Embor.7400133  0.337
2004 Hicks JK, D'Souza CA, Cox GM, Heitman J. Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus neoformans. Eukaryotic Cell. 3: 14-26. PMID 14871933 DOI: 10.1128/Ec.3.1.14-26.2004  0.387
2004 Fraser JA, Heitman J. Evolution of fungal sex chromosomes. Molecular Microbiology. 51: 299-306. PMID 14756773 DOI: 10.1046/J.1365-2958.2003.03874.X  0.606
2003 Litvintseva AP, Marra RE, Nielsen K, Heitman J, Vilgalys R, Mitchell TG. Evidence of sexual recombination among Cryptococcus neoformans serotype A isolates in sub-Saharan Africa. Eukaryotic Cell. 2: 1162-8. PMID 14665451 DOI: 10.1128/Ec.2.6.1162-1168.2003  0.639
2003 Kraus PR, Heitman J. Coping with stress: calmodulin and calcineurin in model and pathogenic fungi. Biochemical and Biophysical Research Communications. 311: 1151-7. PMID 14623301 DOI: 10.1016/S0006-291X(03)01528-6  0.363
2003 de Jesús-Berríos M, Liu L, Nussbaum JC, Cox GM, Stamler JS, Heitman J. Enzymes that counteract nitrosative stress promote fungal virulence. Current Biology : Cb. 13: 1963-8. PMID 14614821 DOI: 10.1016/J.Cub.2003.10.029  0.371
2003 Fraser JA, Heitman J. Fungal mating-type loci. Current Biology : Cb. 13: R792-5. PMID 14561417 DOI: 10.1016/J.Cub.2003.09.046  0.513
2003 Fraser JA, Subaran RL, Nichols CB, Heitman J. Recapitulation of the sexual cycle of the primary fungal pathogen Cryptococcus neoformans var. gattii: implications for an outbreak on Vancouver Island, Canada. Eukaryotic Cell. 2: 1036-45. PMID 14555486 DOI: 10.1128/Ec.2.5.1036-1045.2003  0.63
2003 Fox DS, Cox GM, Heitman J. Phospholipid-binding protein Cts1 controls septation and functions coordinately with calcineurin in Cryptococcus neoformans. Eukaryotic Cell. 2: 1025-35. PMID 14555485 DOI: 10.1128/Ec.2.5.1025-1035.2003  0.4
2003 Young LY, Hull CM, Heitman J. Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae. Antimicrobial Agents and Chemotherapy. 47: 2717-24. PMID 12936965 DOI: 10.1128/Aac.47.9.2717-2724.2003  0.6
2003 Nielsen K, Cox GM, Wang P, Toffaletti DL, Perfect JR, Heitman J. Sexual cycle of Cryptococcus neoformans var. grubii and virulence of congenic a and alpha isolates. Infection and Immunity. 71: 4831-41. PMID 12933823 DOI: 10.1128/Iai.71.9.4831-4841.2003  0.668
2003 Davidson RC, Nichols CB, Cox GM, Perfect JR, Heitman J. A MAP kinase cascade composed of cell type specific and non-specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans. Molecular Microbiology. 49: 469-85. PMID 12828643 DOI: 10.1046/J.1365-2958.2003.03563.X  0.677
2003 Blankenship JR, Wormley FL, Boyce MK, Schell WA, Filler SG, Perfect JR, Heitman J. Calcineurin is essential for Candida albicans survival in serum and virulence. Eukaryotic Cell. 2: 422-30. PMID 12796287 DOI: 10.1128/Ec.2.3.422-430.2003  0.75
2003 Kraus PR, Fox DS, Cox GM, Heitman J. The Cryptococcus neoformans MAP kinase Mpk1 regulates cell integrity in response to antifungal drugs and loss of calcineurin function. Molecular Microbiology. 48: 1377-87. PMID 12787363 DOI: 10.1046/J.1365-2958.2003.03508.X  0.339
2003 Blankenship JR, Steinbach WJ, Perfect JR, Heitman J. Teaching old drugs new tricks: reincarnating immunosuppressants as antifungal drugs. Current Opinion in Investigational Drugs (London, England : 2000). 4: 192-9. PMID 12669381  0.68
2003 Roberts RJ, Belfort M, Bestor T, Bhagwat AS, Bickle TA, Bitinaite J, Blumenthal RM, Degtyarev SKh, Dryden DT, Dybvig K, Firman K, Gromova ES, Gumport RI, Halford SE, Hattman S, ... Heitman J, et al. A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes. Nucleic Acids Research. 31: 1805-12. PMID 12654995 DOI: 10.1093/Nar/Gkg274  0.307
2003 Onyewu C, Blankenship JR, Del Poeta M, Heitman J. Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei. Antimicrobial Agents and Chemotherapy. 47: 956-64. PMID 12604527 DOI: 10.1128/Aac.47.3.956-964.2003  0.811
2003 Waugh MS, Vallim MA, Heitman J, Alspaugh JA. Ras1 controls pheromone expression and response during mating in Cryptococcus neoformans. Fungal Genetics and Biology : Fg & B. 38: 110-21. PMID 12553941 DOI: 10.1016/S1087-1845(02)00518-2  0.377
2002 Hull CM, Davidson RC, Heitman J. Cell identity and sexual development in Cryptococcus neoformans are controlled by the mating-type-specific homeodomain protein Sxi1alpha. Genes & Development. 16: 3046-60. PMID 12464634 DOI: 10.1101/Gad.1041402  0.749
2002 Shen WC, Davidson RC, Cox GM, Heitman J. Pheromones stimulate mating and differentiation via paracrine and autocrine signaling in Cryptococcus neoformans. Eukaryotic Cell. 1: 366-77. PMID 12455985 DOI: 10.1128/Ec.1.3.366-377.2002  0.799
2002 Alspaugh JA, Pukkila-Worley R, Harashima T, Cavallo LM, Funnell D, Cox GM, Perfect JR, Kronstad JW, Heitman J. Adenylyl cyclase functions downstream of the Galpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans. Eukaryotic Cell. 1: 75-84. PMID 12455973 DOI: 10.1128/Ec.1.1.75-84.2002  0.415
2002 Wang P, Nichols CB, Lengeler KB, Cardenas ME, Cox GM, Perfect JR, Heitman J. Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans. Eukaryotic Cell. 1: 257-72. PMID 12455960 DOI: 10.1128/Ec.1.2.257-272.2002  0.474
2002 Lengeler KB, Fox DS, Fraser JA, Allen A, Forrester K, Dietrich FS, Heitman J. Mating-type locus of Cryptococcus neoformans: a step in the evolution of sex chromosomes. Eukaryotic Cell. 1: 704-18. PMID 12455690 DOI: 10.1128/Ec.1.5.704-718.2002  0.614
2002 Hull CM, Heitman J. Fungal mating: Candida albicans flips a switch to get in the mood. Current Biology : Cb. 12: R782-4. PMID 12445405 DOI: 10.1016/S0960-9822(02)01293-9  0.578
2002 Mylonakis E, Ausubel FM, Perfect JR, Heitman J, Calderwood SB. Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis. Proceedings of the National Academy of Sciences of the United States of America. 99: 15675-80. PMID 12438649 DOI: 10.1073/Pnas.232568599  0.356
2002 Hull CM, Heitman J. Genetics of Cryptococcus neoformans. Annual Review of Genetics. 36: 557-615. PMID 12429703 DOI: 10.1146/Annurev.Genet.36.052402.152652  0.657
2002 Fox DS, Heitman J. Good fungi gone bad: the corruption of calcineurin. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 24: 894-903. PMID 12325122 DOI: 10.1002/Bies.10157  0.399
2002 Schein JE, Tangen KL, Chiu R, Shin H, Lengeler KB, MacDonald WK, Bosdet I, Heitman J, Jones SJ, Marra MA, Kronstad JW. Physical maps for genome analysis of serotype A and D strains of the fungal pathogen Cryptococcus neoformans. Genome Research. 12: 1445-53. PMID 12213782 DOI: 10.1101/Gr.81002  0.338
2002 Davidson RC, Blankenship JR, Kraus PR, de Jesus Berrios M, Hull CM, D'Souza C, Wang P, Heitman J. A PCR-based strategy to generate integrative targeting alleles with large regions of homology. Microbiology (Reading, England). 148: 2607-15. PMID 12177355 DOI: 10.1099/00221287-148-8-2607  0.816
2002 Pan X, Heitman J. Protein kinase A operates a molecular switch that governs yeast pseudohyphal differentiation. Molecular and Cellular Biology. 22: 3981-93. PMID 12024012 DOI: 10.1128/Mcb.22.12.3981-3993.2002  0.502
2002 Cruz MC, Goldstein AL, Blankenship JR, Del Poeta M, Davis D, Cardenas ME, Perfect JR, McCusker JH, Heitman J. Calcineurin is essential for survival during membrane stress in Candida albicans. The Embo Journal. 21: 546-59. PMID 11847103 DOI: 10.1093/Emboj/21.4.546  0.72
2002 Waugh MS, Nichols CB, DeCesare CM, Cox GM, Heitman J, Alspaugh JA. Ras1 and Ras2 contribute shared and unique roles in physiology and virulence of Cryptococcus neoformans. Microbiology (Reading, England). 148: 191-201. PMID 11782511 DOI: 10.1099/00221287-148-1-191  0.38
2002 D'Souza CA, Heitman J. It infects me, it infects me not: phenotypic switching in the fungal pathogen Cryptococcus neoformans. The Journal of Clinical Investigation. 108: 1577-8. PMID 11733551 DOI: 10.1172/Jci14497  0.421
2001 Cutler NS, Pan X, Heitman J, Cardenas ME. The TOR signal transduction cascade controls cellular differentiation in response to nutrients. Molecular Biology of the Cell. 12: 4103-13. PMID 11739804 DOI: 10.1091/Mbc.12.12.4103  0.8
2001 Cruz MC, Goldstein AL, Blankenship J, Del Poeta M, Perfect JR, McCusker JH, Bennani YL, Cardenas ME, Heitman J. Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR. Antimicrobial Agents and Chemotherapy. 45: 3162-70. PMID 11600372 DOI: 10.1128/Aac.45.11.3162-3170.2001  0.737
2001 Wang P, Cardenas ME, Cox GM, Perfect JR, Heitman J. Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans. Embo Reports. 2: 511-8. PMID 11415984 DOI: 10.1093/Embo-Reports/Kve109  0.402
2001 D'Souza CA, Heitman J. Conserved cAMP signaling cascades regulate fungal development and virulence. Fems Microbiology Reviews. 25: 349-64. PMID 11348689 DOI: 10.1111/J.1574-6976.2001.Tb00582.X  0.325
2001 D'Souza CA, Alspaugh JA, Yue C, Harashima T, Cox GM, Perfect JR, Heitman J. Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans. Molecular and Cellular Biology. 21: 3179-91. PMID 11287622 DOI: 10.1128/Mcb.21.9.3179-3191.2001  0.405
2001 Rohde J, Heitman J, Cardenas ME. The TOR Kinases Link Nutrient Sensing to Cell Growth Journal of Biological Chemistry. 276: 9583-9586. PMID 11266435 DOI: 10.1074/Jbc.R000034200  0.328
2001 Liu L, Hausladen A, Zeng M, Que L, Heitman J, Stamler JS. A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans Nature. 410: 490-494. PMID 11260719 DOI: 10.1038/35068596  0.352
2001 Fox DS, Cruz MC, Sia RA, Ke H, Cox GM, Cardenas ME, Heitman J. Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans. Molecular Microbiology. 39: 835-49. PMID 11251806 DOI: 10.1046/J.1365-2958.2001.02295.X  0.374
2001 Cruz MC, Fox DS, Heitman J. Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans. The Embo Journal. 20: 1020-32. PMID 11230126 DOI: 10.1093/Emboj/20.5.1020  0.395
2001 Lengeler KB, Cox GM, Heitman J. Serotype AD strains of Cryptococcus neoformans are diploid or aneuploid and are heterozygous at the mating-type locus. Infection and Immunity. 69: 115-22. PMID 11119496 DOI: 10.1128/Iai.69.1.115-122.2001  0.326
2000 Davidson RC, Moore TD, Odom AR, Heitman J. Characterization of the MFalpha pheromone of the human fungal pathogen cryptococcus neoformans. Molecular Microbiology. 38: 1017-26. PMID 11123675 DOI: 10.1046/J.1365-2958.2000.02213.X  0.414
2000 Pan X, Harashima T, Heitman J. Signal transduction cascades regulating pseudohyphal differentiation of Saccharomyces cerevisiae. Current Opinion in Microbiology. 3: 567-72. PMID 11121775 DOI: 10.1016/S1369-5274(00)00142-9  0.534
2000 Lengeler KB, Wang P, Cox GM, Perfect JR, Heitman J. Identification of the MATa mating-type locus of Cryptococcus neoformans reveals a serotype A MATa strain thought to have been extinct. Proceedings of the National Academy of Sciences of the United States of America. 97: 14455-60. PMID 11121047 DOI: 10.1073/Pnas.97.26.14455  0.432
2000 Lengeler KB, Davidson RC, D'souza C, Harashima T, Shen WC, Wang P, Pan X, Waugh M, Heitman J. Signal transduction cascades regulating fungal development and virulence. Microbiology and Molecular Biology Reviews : Mmbr. 64: 746-85. PMID 11104818 DOI: 10.1128/Mmbr.64.4.746-785.2000  0.539
2000 Heitman J, Casadevall A, Lodge JK, Perfect JR. The Cryptococcus neoformans genome sequencing project. Mycopathologia. 148: 1-7. PMID 11086479 DOI: 10.1023/A:1007136602930  0.37
2000 Pan X, Heitman J. Sok2 regulates yeast pseudohyphal differentiation via a transcription factor cascade that regulates cell-cell adhesion. Molecular and Cellular Biology. 20: 8364-72. PMID 11046133 DOI: 10.1128/Mcb.20.22.8364-8372.2000  0.52
2000 Arévalo-Rodríguez M, Cardenas ME, Wu X, Hanes SD, Heitman J. Cyclophilin A and Ess1 interact with and regulate silencing by the Sin3-Rpd3 histone deacetylase. The Embo Journal. 19: 3739-49. PMID 10899127 DOI: 10.1093/Emboj/19.14.3739  0.334
2000 Wu X, Wilcox CB, Devasahayam G, Hackett RL, Arévalo-Rodríguez M, Cardenas ME, Heitman J, Hanes SD. The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery. The Embo Journal. 19: 3727-38. PMID 10899126 DOI: 10.1093/Emboj/19.14.3727  0.329
2000 Görlach J, Fox DS, Cutler NS, Cox GM, Perfect JR, Heitman J. Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans. The Embo Journal. 19: 3618-29. PMID 10899116 DOI: 10.1093/Emboj/19.14.3618  0.785
2000 Sia RA, Lengeler KB, Heitman J. Diploid strains of the pathogenic basidiomycete cryptococcus neoformans are thermally dimorphic Fungal Genetics and Biology. 29: 153-163. PMID 10882532 DOI: 10.1006/Fgbi.2000.1192  0.387
2000 Alspaugh JA, Davidson RC, Heitman J. Morphogenesis of Cryptococcus neoformans. Contributions to Microbiology. 5: 217-38. PMID 10863675 DOI: 10.1159/000060352  0.377
2000 Alspaugh JA, Cavallo LM, Perfect JR, Heitman J. RAS1 regulates filamentation, mating and growth at high temperature of Cryptococcus neoformans. Molecular Microbiology. 36: 352-65. PMID 10792722 DOI: 10.1046/J.1365-2958.2000.01852.X  0.399
2000 Davidson RC, Cruz MC, Sia RAL, Allen B, Alspaugh JA, Heitman J. Gene disruption by biolistic transformation in serotype D strains of Cryptococcus neoformans Fungal Genetics and Biology. 29: 38-48. PMID 10779398 DOI: 10.1006/Fgbi.1999.1180  0.356
2000 Liu L, Zeng M, Hausladen A, Heitman J, Stamler JS. Protection from nitrosative stress by yeast flavohemoglobin Proceedings of the National Academy of Sciences of the United States of America. 97: 4672-4676. PMID 10758168 DOI: 10.1073/Pnas.090083597  0.338
2000 Del Poeta M, Cruz MC, Cardenas ME, Perfect JR, Heitman J. Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans. Antimicrobial Agents and Chemotherapy. 44: 739-46. PMID 10681348 DOI: 10.1128/Aac.44.3.739-746.2000  0.363
2000 Lorenz MC, Pan X, Harashima T, Cardenas ME, Xue Y, Hirsch JP, Heitman J. The G protein-coupled receptor gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Genetics. 154: 609-22. PMID 10655215  0.436
2000 Cruz MC, Sia RA, Olson M, Cox GM, Heitman J. Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans. Infection and Immunity. 68: 982-5. PMID 10639477 DOI: 10.1128/Iai.68.2.982-985.2000  0.316
2000 Lorenz MC, Cutler NS, Heitman J. Characterization of alcohol-induced filamentous growth in Saccharomyces cerevisiae. Molecular Biology of the Cell. 11: 183-99. PMID 10637301 DOI: 10.1091/Mbc.11.1.183  0.761
2000 Cruz MC, Del Poeta M, Wang P, Wenger R, Zenke G, Quesniaux VF, Movva NR, Perfect JR, Cardenas ME, Heitman J. Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin. Antimicrobial Agents and Chemotherapy. 44: 143-9. PMID 10602736 DOI: 10.1128/Aac.44.1.143-149.2000  0.348
2000 Wang P, Perfect JR, Heitman J. The G-protein beta subunit GPB1 is required for mating and haploid fruiting in Cryptococcus neoformans. Molecular and Cellular Biology. 20: 352-62. PMID 10594037 DOI: 10.1128/Mcb.20.1.352-362.2000  0.397
1999 Cardenas ME, Cutler NS, Lorenz MC, Di Como CJ, Heitman J. The TOR signaling cascade regulates gene expression in response to nutrients. Genes & Development. 13: 3271-9. PMID 10617575 DOI: 10.1101/Gad.13.24.3271  0.785
1999 Cutler NS, Heitman J, Cardenas ME. TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals. Molecular and Cellular Endocrinology. 155: 135-42. PMID 10580846 DOI: 10.1016/S0303-7207(99)00121-5  0.779
1999 Heitman J, Allen B, Alspaugh JA, Kwon-Chung KJ. On the origins of congenic MATalpha and MATa strains of the pathogenic yeast Cryptococcus neoformans. Fungal Genetics and Biology : Fg & B. 28: 1-5. PMID 10512666 DOI: 10.1006/Fgbi.1999.1155  0.379
1999 Arndt C, Cruz MC, Cardenas ME, Heitman J. Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans Microbiology. 145: 1989-2000. PMID 10463165 DOI: 10.1099/13500872-145-8-1989  0.388
1999 Wang P, Heitman J. Signal transduction cascades regulating mating, filamentation, and virulence in Cryptococcus neoformans. Current Opinion in Microbiology. 2: 358-62. PMID 10458985 DOI: 10.1016/S1369-5274(99)80063-0  0.397
1999 Alarcon CM, Heitman J, Cardenas ME. Protein Kinase Activity and Identification of a Toxic Effector Domain of the Target of Rapamycin TOR Proteins in Yeast Molecular Biology of the Cell. 10: 2531-2546. PMID 10436010 DOI: 10.1091/Mbc.10.8.2531  0.331
1999 Joseph JD, Heitman J, Means AR. Molecular cloning and characterization of Aspergillus nidulans cyclophilin B. Fungal Genetics and Biology : Fg & B. 27: 55-66. PMID 10413615 DOI: 10.1006/Fgbi.1999.1131  0.331
1999 Sudarshan S, Davidson RC, Heitman J, Alspaugh JA. Molecular analysis of the Cryptococcus neoformans ADE2 gene, a selectable marker for transformation and gene disruption. Fungal Genetics and Biology : Fg & B. 27: 36-48. PMID 10413613 DOI: 10.1006/Fgbi.1999.1126  0.389
1999 Pan X, Heitman J. Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Molecular and Cellular Biology. 19: 4874-87. PMID 10373537 DOI: 10.1128/Mcb.19.7.4874  0.516
1999 Cruz MC, Cavallo LM, Görlach JM, Cox G, Perfect JR, Cardenas ME, Heitman J. Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. Molecular and Cellular Biology. 19: 4101-12. PMID 10330150 DOI: 10.1128/Mcb.19.6.4101  0.418
1999 Hemenway CS, Heitman J. Lic4, a nuclear phosphoprotein that cooperates with calcineurin to regulate cation homeostasis in Saccharomyces cerevisiae. Molecular & General Genetics : Mgg. 261: 388-401. PMID 10102375 DOI: 10.1007/S004380050980  0.731
1999 Hemenway CS, Heitman J. Calcineurin. Structure, function, and inhibition. Cell Biochemistry and Biophysics. 30: 115-51. PMID 10099825 DOI: 10.1007/Bf02737887  0.717
1999 del Poeta M, Toffaletti DL, Rude TH, Sparks SD, Heitman J, Perfect JR. Cryptococcus neoformans Differential Gene Expression Detected In Vitro and In Vivo with Green Fluorescent Protein Infection and Immunity. 67: 1812-1820. DOI: 10.1128/Iai.67.4.1812-1820.1999  0.354
1999 Cardenas ME, Cruz MC, Del Poeta M, Chung N, Perfect JR, Heitman J. Antifungal Activities of Antineoplastic Agents:Saccharomyces cerevisiae as a Model System To Study Drug Action Clinical Microbiology Reviews. 12: 583-611. DOI: 10.1128/Cmr.12.4.583  0.337
1998 Dolinski KJ, Cardenas ME, Heitman J. CNS1 encodes an essential p60/Sti1 homolog in Saccharomyces cerevisiae that suppresses cyclophilin 40 mutations and interacts with Hsp90. Molecular and Cellular Biology. 18: 7344-7352. PMID 9819421 DOI: 10.1128/Mcb.18.12.7344  0.34
1998 Cardenas ME, Sanfridson A, Cutler NS, Heitman J. Signal-transduction cascades as targets for therapeutic intervention by natural products. Trends in Biotechnology. 16: 427-33. PMID 9807840 DOI: 10.1016/S0167-7799(98)01239-6  0.761
1998 Alspaugh JA, Perfect JR, Heitman J. Signal transduction pathways regulating differentiation and pathogenicity of Cryptococcus neoformans. Fungal Genetics and Biology : Fg & B. 25: 1-14. PMID 9806801 DOI: 10.1006/Fgbi.1998.1079  0.393
1998 Zaragoza D, Ghavidel A, Heitman J, Schultz MC. Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway. Molecular and Cellular Biology. 18: 4463-70. PMID 9671456 DOI: 10.1128/Mcb.18.8.4463  0.318
1998 Lorenz MC, Heitman J. The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae. The Embo Journal. 17: 1236-47. PMID 9482721 DOI: 10.1093/Emboj/17.5.1236  0.343
1997 Muir RS, Flores H, Zinder ND, Model P, Soberon X, Heitman J. Temperature-sensitive mutants of the EcoRI endonuclease. Journal of Molecular Biology. 274: 722-37. PMID 9405154 DOI: 10.1006/Jmbi.1997.1419  0.709
1997 Alspaugh JA, Perfect JR, Heitman J. Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP. Genes & Development. 11: 3206-17. PMID 9389652 DOI: 10.1101/Gad.11.23.3206  0.407
1997 Lorenz MC, Heitman J. Yeast pseudohyphal growth is regulated by GPA2, a G protein α homolog The Embo Journal. 16: 7008-7018. PMID 9384580 DOI: 10.1093/Emboj/16.23.7008  0.355
1997 Dolinski K, Muir S, Cardenas M, Heitman J. All cyclophilins and FK506 binding proteins are, individually and collectively, dispensable for viability in Saccharomyces cerevisiae Proceedings of the National Academy of Sciences of the United States of America. 94: 13093-13098. PMID 9371805 DOI: 10.1073/Pnas.94.24.13093  0.343
1997 Cutler NS, Heitman J, Cardenas ME. STT4 is an essential phosphatidylinositol 4-kinase that is a target of wortmannin in Saccharomyces cerevisiae. The Journal of Biological Chemistry. 272: 27671-7. PMID 9346907 DOI: 10.1074/Jbc.272.44.27671  0.771
1997 Alarcón CM, Heitman J. Fkbp12 Physically And Functionally Interacts With Aspartokinase In Saccharomyces Cerevisiae Molecular and Cellular Biology. 17: 5968-5975. PMID 9315655 DOI: 10.1128/Mcb.17.10.5968  0.328
1997 Odom A, Muir S, Lim E, Toffaletti DL, Perfect J, Heitman J. Calcineurin is required for virulence of Cryptococcus neoformans. The Embo Journal. 16: 2576-89. PMID 9184205 DOI: 10.1093/Emboj/16.10.2576  0.406
1997 Odom A, Del Poeta M, Perfect J, Heitman J. The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein. Antimicrobial Agents and Chemotherapy. 41: 156-161. DOI: 10.1128/Aac.41.1.156  0.35
1996 Hemenway CS, Heitman J. Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast. The Journal of Biological Chemistry. 271: 18527-34. PMID 8702500 DOI: 10.1074/Jbc.271.31.18527  0.726
1996 Ruetz S, Brault M, Kast C, Hemenway C, Heitman J, Grant CE, Cole SP, Deeley RG, Gros P. Functional expression of the multidrug resistance-associated protein in the yeast Saccharomyces cerevisiae. The Journal of Biological Chemistry. 271: 4154-60. PMID 8626756 DOI: 10.1074/Jbc.271.8.4154  0.708
1996 Alarcon CM, Cardenas ME, Heitman J. Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast. Genes & Development. 10: 279-288. PMID 8595879 DOI: 10.1101/Gad.10.3.279  0.337
1996 Lorenz MC, Heitman J. TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin. The Journal of Biological Chemistry. 270: 27531-7. PMID 7499212 DOI: 10.1074/Jbc.270.46.27531  0.329
1995 Cardenas ME, Zhu D, Heitman J. Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin Current Opinion in Nephrology and Hypertension. 4: 472-477. PMID 8591053 DOI: 10.1097/00041552-199511000-00002  0.307
1995 Lorenz MC, Muir RS, Lim E, McElver J, Weber SC, Heitman J. Gene disruption with PCR products in Saccharomyces cerevisiae. Gene. 158: 113-7. PMID 7789793 DOI: 10.1016/0378-1119(95)00144-U  0.336
1995 Cardenas ME, Lim E, Heitman J. Mutations that perturb cyclophilin A ligand binding pocket confer cyclosporin A resistance in Saccharomyces cerevisiae. Journal of Biological Chemistry. 270: 20997-21002. PMID 7673124 DOI: 10.1074/Jbc.270.36.20997  0.326
1995 Zhu D, Cardenas ME, Heitman J. Myristoylation of Calcineurin B Is Not Required for Function or Interaction with Immunophilin-Immunosuppressant Complexes in the Yeast Saccharomyces cerevisiae Journal of Biological Chemistry. 270: 24831-24838. PMID 7559604 DOI: 10.1074/Jbc.270.42.24831  0.325
1995 Cardenas ME, Muir RS, Breuder T, Heitman J. Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A. The Embo Journal. 14: 2772-2783. DOI: 10.1002/J.1460-2075.1995.Tb07277.X  0.313
1995 Cardenas ME, Heitman J. FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity. The Embo Journal. 14: 5892-5907. DOI: 10.1002/J.1460-2075.1995.Tb00277.X  0.341
1994 Hemenway C, Heitman J. Proline isomerases in microorganisms and small eukaryotes. Annals of the New York Academy of Sciences. 696: 38-46. PMID 8109845 DOI: 10.1111/J.1749-6632.1993.Tb17140.X  0.688
1994 Cullen BR, Heitman J. Chaperoning a pathogen Nature. 372: 319-320. PMID 7526224 DOI: 10.1038/372319A0  0.335
1994 Breuder T, Hemenway CS, Movva NR, Cardenas ME, Heitman J. Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains. Proceedings of the National Academy of Sciences of the United States of America. 91: 5372-6. PMID 7515500 DOI: 10.1073/Pnas.91.12.5372  0.719
1994 Cardenas ME, Lorenz M, Hemenway C, Heitman J. Yeast as model T cells Perspectives in Drug Discovery and Design. 2: 103-126. DOI: 10.1007/Bf02171739  0.716
1993 Heitman J, Koller A, Cardenas ME, Hall MN. Identification of Immunosuppressive Drug Targets in Yeast Methods. 5: 176-187. DOI: 10.1006/Meth.1993.1022  0.32
1992 Davis ES, Becker A, Heitman J, Hall MN, Brennan MB. A yeast cyclophilin gene essential for lactate metabolism at high temperature Proceedings of the National Academy of Sciences of the United States of America. 89: 11169-11173. PMID 1454795 DOI: 10.1073/Pnas.89.23.11169  0.352
1991 Heitman J, Model P. SOS induction as an in vivo assay of enzyme-DNA interactions. Gene. 103: 1-9. PMID 1908806 DOI: 10.1016/0378-1119(91)90383-M  0.562
1991 Heitman J, Movva NR, Hiestand PC, Hall MN. FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae Proceedings of the National Academy of Sciences of the United States of America. 88: 1948-1952. PMID 1705713 DOI: 10.1073/Pnas.88.5.1948  0.361
1990 Heitman J, Model P. Mutants of the EcoRI endonuclease with promiscuous substrate specificity implicate residues involved in substrate recognition. The Embo Journal. 9: 3369-78. PMID 2209548 DOI: 10.1002/J.1460-2075.1990.Tb07538.X  0.583
1990 Heitman J, Model P. Substrate recognition by the EcoRI endonuclease. Proteins. 7: 185-97. PMID 2139225 DOI: 10.1002/Prot.340070207  0.574
1989 Heitman J, Fulford W, Model P. Phage Trojan horses: a conditional expression system for lethal genes. Gene. 85: 193-7. PMID 2695397 DOI: 10.1016/0378-1119(89)90480-0  0.618
1989 Heitman J, Zinder ND, Model P. Repair of the Escherichia coli chromosome after in vivo scission by the EcoRI endonuclease. Proceedings of the National Academy of Sciences of the United States of America. 86: 2281-5. PMID 2648397 DOI: 10.1073/Pnas.86.7.2281  0.698
1987 Heitman J, Model P. Site-specific methylases induce the SOS DNA repair response in Escherichia coli. Journal of Bacteriology. 169: 3243-50. PMID 3036779 DOI: 10.1128/Jb.169.7.3243-3250.1987  0.56
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