| Year |
Citation |
Score |
| 2023 |
Sabharwal SS, Dudley VJ, Landwerlin C, Schumacker PT. HO transit through the mitochondrial intermembrane space promotes tumor cell growth in vitro and in vivo. The Journal of Biological Chemistry. 299: 104624. PMID 36935009 DOI: 10.1016/j.jbc.2023.104624 |
0.381 |
|
| 2022 |
Cabello-Rivera D, Ortega-Sáenz P, Gao L, Muñoz-Cabello AM, Bonilla-Henao V, Schumacker PT, López-Barneo J. Oxygen regulation of breathing is abolished in mitochondrial complex III-deficient arterial chemoreceptors. Proceedings of the National Academy of Sciences of the United States of America. 119: e2202178119. PMID 36122208 DOI: 10.1073/pnas.2202178119 |
0.389 |
|
| 2022 |
Murphy MP, Bayir H, Belousov V, Chang CJ, Davies KJA, Davies MJ, Dick TP, Finkel T, Forman HJ, Janssen-Heininger Y, Gems D, Kagan VE, Kalyanaraman B, Larsson NG, Milne GL, ... ... Schumacker PT, et al. Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo. Nature Metabolism. 4: 651-662. PMID 35760871 DOI: 10.1038/s42255-022-00591-z |
0.302 |
|
| 2019 |
Graves SM, Xie Z, Stout KA, Zampese E, Burbulla LF, Shih JC, Kondapalli J, Patriarchi T, Tian L, Brichta L, Greengard P, Krainc D, Schumacker PT, Surmeier DJ. Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain. Nature Neuroscience. PMID 31844313 DOI: 10.1038/S41593-019-0556-3 |
0.345 |
|
| 2019 |
Waypa GB, Schumacker PT. Roles of HIF1 and HIF2 in pulmonary hypertension: it all depends on the context. The European Respiratory Journal. 54. PMID 31831673 DOI: 10.1183/13993003.01929-2019 |
0.373 |
|
| 2019 |
Galvan DL, Long J, Green N, Chang BH, Lin JS, Schumacker PT, Truong LD, Overbeek P, Danesh FR. Drp1S600 phosphorylation regulates mitochondrial fission and progression of nephropathy in diabetic mice. The Journal of Clinical Investigation. 130. PMID 31063459 DOI: 10.1172/Jci127277 |
0.378 |
|
| 2019 |
Weinberg SE, Singer BD, Steinert EM, Martinez CA, Mehta MM, Martínez-Reyes I, Gao P, Helmin KA, Abdala-Valencia H, Sena LA, Schumacker PT, Turka LA, Chandel NS. Mitochondrial complex III is essential for suppressive function of regulatory T cells. Nature. PMID 30626970 DOI: 10.1038/S41586-018-0846-Z |
0.311 |
|
| 2018 |
Zhang S, Weinberg S, DeBerge M, Gainullina A, Schipma M, Kinchen JM, Ben-Sahra I, Gius DR, Charvet LY, Chandel NS, Schumacker PT, Thorp EB. Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair. Cell Metabolism. PMID 30595481 DOI: 10.1016/J.Cmet.2018.12.004 |
0.346 |
|
| 2018 |
Smith KA, Schumacker PT. Sensors and signals: the role of reactive oxygen species in hypoxic pulmonary vasoconstriction. The Journal of Physiology. PMID 30091476 DOI: 10.1113/Jp275852 |
0.466 |
|
| 2018 |
Guzman JN, Ilijic E, Yang B, Sanchez-Padilla J, Wokosin D, Galtieri D, Kondapalli J, Schumacker PT, Surmeier DJ. Systemic isradipine treatment diminishes calcium-dependent mitochondrial oxidant stress. The Journal of Clinical Investigation. PMID 29708514 DOI: 10.1172/Jci95898 |
0.371 |
|
| 2018 |
Ofman G, Waypa G, Dudley J, Smith K, Schumacker P. Mitochondrial Complex III regulates proliferative arrest in postnatal cardiomyocytes Pediatrics. 142: 207-207. DOI: 10.1542/Peds.142.1_Meetingabstract.207 |
0.335 |
|
| 2017 |
Sala MA, Chen C, Zhang Q, Do-Umehara HC, Wu W, Misharin AV, Waypa GB, Fang D, Budinger GRS, Liu S, Chandel NS, Schumacker PT, Sznajder JI, Liu J. JNK2 Upregulates Hypoxia-Inducible Factors and Contributes to Hypoxia-Induced Erythropoiesis and Pulmonary Hypertension. The Journal of Biological Chemistry. PMID 29118187 DOI: 10.1074/Jbc.Ra117.000440 |
0.4 |
|
| 2017 |
Rines AK, Chang HC, Wu R, Sato T, Khechaduri A, Kouzu H, Shapiro J, Shang M, Burke MA, Abdelwahid E, Jiang X, Chen C, Rawlings TA, Lopaschuk GD, Schumacker PT, et al. Corrigendum: Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling. Nature Communications. 8: 16155. PMID 28853433 DOI: 10.1038/Ncomms16155 |
0.363 |
|
| 2017 |
Galvan DL, Badal SS, Long J, Chang BH, Schumacker PT, Overbeek PA, Danesh FR. Real-time in vivo mitochondrial redox assessment confirms enhanced mitochondrial reactive oxygen species in diabetic nephropathy. Kidney International. PMID 28754553 DOI: 10.1016/J.Kint.2017.05.015 |
0.423 |
|
| 2017 |
Smith KA, Waypa GB, Schumacker PT. Redox signaling during hypoxia in mammalian cells. Redox Biology. 13: 228-234. PMID 28595160 DOI: 10.1016/J.Redox.2017.05.020 |
0.494 |
|
| 2017 |
Ansó E, Weinberg SE, Diebold LP, Thompson BJ, Malinge S, Schumacker PT, Liu X, Zhang Y, Shao Z, Steadman M, Marsh KM, Xu J, Crispino JD, Chandel NS. The mitochondrial respiratory chain is essential for haematopoietic stem cell function. Nature Cell Biology. PMID 28504706 DOI: 10.1038/Ncb3529 |
0.322 |
|
| 2017 |
Shi H, Deng HX, Gius D, Schumacker PT, James Surmeier D, Ma YC. Sirt3 Protects Dopaminergic Neurons from Mitochondrial Oxidative Stress. Human Molecular Genetics. PMID 28369333 DOI: 10.1093/Hmg/Ddx100 |
0.371 |
|
| 2017 |
Rines AK, Chang HC, Wu R, Sato T, Khechaduri A, Kouzu H, Shapiro J, Shang M, Burke MA, Jiang X, Chen C, Rawlings TA, Lopaschuk GD, Schumacker PT, Abel ED, et al. Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling. Nature Communications. 8: 14095. PMID 28117339 DOI: 10.1038/Ncomms14095 |
0.406 |
|
| 2016 |
Surmeier DJ, Schumacker PT, Guzman JD, Ilijic E, Yang B, Zampese E. Calcium and Parkinson's disease. Biochemical and Biophysical Research Communications. PMID 27590583 DOI: 10.1016/J.Bbrc.2016.08.168 |
0.345 |
|
| 2016 |
Israeli E, Dryanovski DI, Schumacker PT, Chandel NS, Singer JD, Julien JP, Goldman RD, Opal P. Intermediate filament aggregates cause mitochondrial dysmotility and increase energy demands in Giant Axonal Neuropathy. Human Molecular Genetics. PMID 27000625 DOI: 10.1093/Hmg/Ddw081 |
0.33 |
|
| 2016 |
Arulkumaran N, Deutschman CS, Pinsky MR, Zuckerbraun B, Schumacker PT, Gomez H, Gomez A, Murray P, Kellum JA. MITOCHONDRIAL FUNCTION IN SEPSIS. Shock (Augusta, Ga.). 45: 271-81. PMID 26871665 DOI: 10.1097/Shk.0000000000000463 |
0.383 |
|
| 2016 |
Ayanga BA, Badal SS, Wang Y, Galvan DL, Chang BH, Schumacker PT, Danesh FR. Dynamin-Related Protein 1 Deficiency Improves Mitochondrial Fitness and Protects against Progression of Diabetic Nephropathy. Journal of the American Society of Nephrology : Jasn. PMID 26825530 DOI: 10.1681/Asn.2015101096 |
0.356 |
|
| 2016 |
Waypa GB, Smith KA, Schumacker PT. O2 sensing, mitochondria and ROS signaling: The fog is lifting. Molecular Aspects of Medicine. PMID 26776678 DOI: 10.1016/J.Mam.2016.01.002 |
0.477 |
|
| 2015 |
Datta A, Kim GA, Taylor JM, Gugino SF, Farrow KN, Schumacker PT, Berkelhamer SK. Mouse Lung Development and NOX1 Induction During Hyperoxia Are Developmentally Regulated and Mitochondrial ROS-Dependent. American Journal of Physiology. Lung Cellular and Molecular Physiology. ajplung.00176.2014. PMID 26092998 DOI: 10.1152/Ajplung.00176.2014 |
0.45 |
|
| 2015 |
Wedgwood S, Lakshminrusimha S, Schumacker PT, Steinhorn RH. Cyclic stretch stimulates mitochondrial reactive oxygen species and Nox4 signaling in pulmonary artery smooth muscle cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 309: L196-203. PMID 26024892 DOI: 10.1152/Ajplung.00097.2014 |
0.442 |
|
| 2015 |
Wedgwood S, Lakshminrusimha S, Schumacker PT, Steinhorn RH. Hypoxia inducible factor signaling and experimental persistent pulmonary hypertension of the newborn. Frontiers in Pharmacology. 6: 47. PMID 25814954 DOI: 10.3389/Fphar.2015.00047 |
0.411 |
|
| 2015 |
Schumacker PT. Reactive oxygen species in cancer: a dance with the devil. Cancer Cell. 27: 156-7. PMID 25670075 DOI: 10.1016/J.Ccell.2015.01.007 |
0.382 |
|
| 2015 |
Takeuchi T, Schumacker PT, Kozmin SA. Identification of fumarate hydratase inhibitors with nutrient-dependent cytotoxicity. Journal of the American Chemical Society. 137: 564-7. PMID 25469852 DOI: 10.1021/Ja5101257 |
0.321 |
|
| 2015 |
Cheresh P, Morales-Nebreda L, Kim SJ, Yeldandi A, Williams DB, Cheng Y, Mutlu GM, Budinger GR, Ridge K, Schumacker PT, Bohr VA, Kamp DW. Asbestos-induced pulmonary fibrosis is augmented in 8-oxoguanine DNA glycosylase knockout mice. American Journal of Respiratory Cell and Molecular Biology. 52: 25-36. PMID 24918270 DOI: 10.1165/Rcmb.2014-0038Oc |
0.386 |
|
| 2014 |
Sabharwal SS, Schumacker PT. Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel? Nature Reviews. Cancer. 14: 709-21. PMID 25342630 DOI: 10.1038/Nrc3803 |
0.424 |
|
| 2014 |
Schwarzländer M, Wagner S, Ermakova YG, Belousov VV, Radi R, Beckman JS, Buettner GR, Demaurex N, Duchen MR, Forman HJ, Fricker MD, Gems D, Halestrap AP, Halliwell B, Jakob U, ... ... Schumacker PT, et al. The 'mitoflash' probe cpYFP does not respond to superoxide. Nature. 514: E12-4. PMID 25341790 DOI: 10.1038/Nature13858 |
0.359 |
|
| 2014 |
Sanchez-Padilla J, Guzman JN, Ilijic E, Kondapalli J, Galtieri DJ, Yang B, Schieber S, Oertel W, Wokosin D, Schumacker PT, Surmeier DJ. Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase. Nature Neuroscience. 17: 832-40. PMID 24816140 DOI: 10.1038/Nn.3717 |
0.392 |
|
| 2014 |
Schumacker PT, Gillespie MN, Nakahira K, Choi AM, Crouser ED, Piantadosi CA, Bhattacharya J. Mitochondria in lung biology and pathology: more than just a powerhouse. American Journal of Physiology. Lung Cellular and Molecular Physiology. 306: L962-74. PMID 24748601 DOI: 10.1152/Ajplung.00073.2014 |
0.44 |
|
| 2014 |
Kim SJ, Cheresh P, Williams D, Cheng Y, Ridge K, Schumacker PT, Weitzman S, Bohr VA, Kamp DW. Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells. The Journal of Biological Chemistry. 289: 6165-76. PMID 24429287 DOI: 10.1074/Jbc.M113.515130 |
0.434 |
|
| 2014 |
Ball MK, Waypa GB, Mungai PT, Nielsen JM, Czech L, Dudley VJ, Beussink L, Dettman RW, Berkelhamer SK, Steinhorn RH, Shah SJ, Schumacker PT. Regulation of hypoxia-induced pulmonary hypertension by vascular smooth muscle hypoxia-inducible factor-1α. American Journal of Respiratory and Critical Care Medicine. 189: 314-24. PMID 24251580 DOI: 10.1164/Rccm.201302-0302Oc |
0.762 |
|
| 2013 |
Bhalla S, Evens AM, Prachand S, Schumacker PT, Gordon LI. Paradoxical regulation of hypoxia inducible factor-1α (HIF-1α) by histone deacetylase inhibitor in diffuse large B-cell lymphoma. Plos One. 8: e81333. PMID 24312289 DOI: 10.1371/Journal.Pone.0081333 |
0.35 |
|
| 2013 |
Waypa GB, Osborne SW, Marks JD, Berkelhamer SK, Kondapalli J, Schumacker PT. Sirtuin 3 deficiency does not augment hypoxia-induced pulmonary hypertension. American Journal of Respiratory Cell and Molecular Biology. 49: 885-91. PMID 24047466 DOI: 10.1165/Rcmb.2013-0191Oc |
0.508 |
|
| 2013 |
Sabharwal SS, Waypa GB, Marks JD, Schumacker PT. Peroxiredoxin-5 targeted to the mitochondrial intermembrane space attenuates hypoxia-induced reactive oxygen species signalling. The Biochemical Journal. 456: 337-46. PMID 24044889 DOI: 10.1042/Bj20130740 |
0.548 |
|
| 2013 |
Dryanovski DI, Guzman JN, Xie Z, Galteri DJ, Volpicelli-Daley LA, Lee VM, Miller RJ, Schumacker PT, Surmeier DJ. Calcium entry and α-synuclein inclusions elevate dendritic mitochondrial oxidant stress in dopaminergic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 10154-64. PMID 23761910 DOI: 10.1523/Jneurosci.5311-12.2013 |
0.363 |
|
| 2013 |
Schumacker PT. Nitric oxide quenches the fire in heart mitochondria. Nature Medicine. 19: 666-7. PMID 23744141 DOI: 10.1038/Nm.3224 |
0.451 |
|
| 2013 |
Schriewer JM, Peek CB, Bass J, Schumacker PT. ROS-mediated PARP activity undermines mitochondrial function after permeability transition pore opening during myocardial ischemia-reperfusion. Journal of the American Heart Association. 2: e000159. PMID 23598272 DOI: 10.1161/Jaha.113.000159 |
0.422 |
|
| 2013 |
Berkelhamer SK, Kim GA, Radder JE, Wedgwood S, Czech L, Steinhorn RH, Schumacker PT. Developmental differences in hyperoxia-induced oxidative stress and cellular responses in the murine lung. Free Radical Biology & Medicine. 61: 51-60. PMID 23499839 DOI: 10.1016/J.Freeradbiomed.2013.03.003 |
0.414 |
|
| 2013 |
Shah MR, Wedgwood S, Czech L, Kim GA, Lakshminrusimha S, Schumacker PT, Steinhorn RH, Farrow KN. Cyclic stretch induces inducible nitric oxide synthase and soluble guanylate cyclase in pulmonary artery smooth muscle cells. International Journal of Molecular Sciences. 14: 4334-48. PMID 23429274 DOI: 10.3390/Ijms14024334 |
0.436 |
|
| 2013 |
Sena LA, Li S, Jairaman A, Prakriya M, Ezponda T, Hildeman DA, Wang CR, Schumacker PT, Licht JD, Perlman H, Bryce PJ, Chandel NS. Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity. 38: 225-36. PMID 23415911 DOI: 10.1016/J.Immuni.2012.10.020 |
0.373 |
|
| 2013 |
Waypa GB, Marks JD, Guzy RD, Mungai PT, Schriewer JM, Dokic D, Ball MK, Schumacker PT. Superoxide generated at mitochondrial complex III triggers acute responses to hypoxia in the pulmonary circulation. American Journal of Respiratory and Critical Care Medicine. 187: 424-32. PMID 23328522 DOI: 10.1164/Rccm.201207-1294Oc |
0.799 |
|
| 2013 |
Wedgwood S, Lakshminrusimha S, Czech L, Schumacker PT, Steinhorn RH. Increased p22(phox)/Nox4 expression is involved in remodeling through hydrogen peroxide signaling in experimental persistent pulmonary hypertension of the newborn. Antioxidants & Redox Signaling. 18: 1765-76. PMID 23244636 DOI: 10.1089/Ars.2012.4766 |
0.346 |
|
| 2013 |
Surmeier DJ, Schumacker PT. Calcium, bioenergetics, and neuronal vulnerability in Parkinson's disease. The Journal of Biological Chemistry. 288: 10736-41. PMID 23086948 DOI: 10.1074/Jbc.R112.410530 |
0.303 |
|
| 2013 |
Bhalla S, Evens AM, Prachand S, Schumacker PT, Gordon LI. Abstract B201: Targeting HIF-1α in diffuse large B cell lymphoma: Role for HDAC inhibitors. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-B201 |
0.332 |
|
| 2012 |
Surmeier DJ, Guzman JN, Sanchez J, Schumacker PT. Physiological phenotype and vulnerability in Parkinson's disease. Cold Spring Harbor Perspectives in Medicine. 2: a009290. PMID 22762023 DOI: 10.1101/Cshperspect.A009290 |
0.347 |
|
| 2012 |
Wang W, Wang Y, Long J, Wang J, Haudek SB, Overbeek P, Chang BH, Schumacker PT, Danesh FR. Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells. Cell Metabolism. 15: 186-200. PMID 22326220 DOI: 10.1016/J.Cmet.2012.01.009 |
0.398 |
|
| 2012 |
Farrow KN, Lee KJ, Perez M, Schriewer JM, Wedgwood S, Lakshminrusimha S, Smith CL, Steinhorn RH, Schumacker PT. Brief hyperoxia increases mitochondrial oxidation and increases phosphodiesterase 5 activity in fetal pulmonary artery smooth muscle cells. Antioxidants & Redox Signaling. 17: 460-70. PMID 22229392 DOI: 10.1089/Ars.2011.4184 |
0.474 |
|
| 2011 |
Schumacker PT. Lung cell hypoxia: role of mitochondrial reactive oxygen species signaling in triggering responses. Proceedings of the American Thoracic Society. 8: 477-84. PMID 22052923 DOI: 10.1513/pats.201103-032MW |
0.352 |
|
| 2011 |
Surmeier DJ, Guzman JN, Sanchez-Padilla J, Schumacker PT. The role of calcium and mitochondrial oxidant stress in the loss of substantia nigra pars compacta dopaminergic neurons in Parkinson's disease. Neuroscience. 198: 221-31. PMID 21884755 DOI: 10.1016/J.Neuroscience.2011.08.045 |
0.311 |
|
| 2011 |
Mungai PT, Waypa GB, Jairaman A, Prakriya M, Dokic D, Ball MK, Schumacker PT. Hypoxia triggers AMPK activation through reactive oxygen species-mediated activation of calcium release-activated calcium channels. Molecular and Cellular Biology. 31: 3531-45. PMID 21670147 DOI: 10.1128/Mcb.05124-11 |
0.778 |
|
| 2011 |
Murphy MP, Holmgren A, Larsson NG, Halliwell B, Chang CJ, Kalyanaraman B, Rhee SG, Thornalley PJ, Partridge L, Gems D, Nyström T, Belousov V, Schumacker PT, Winterbourn CC. Unraveling the biological roles of reactive oxygen species. Cell Metabolism. 13: 361-6. PMID 21459321 DOI: 10.1016/J.Cmet.2011.03.010 |
0.375 |
|
| 2011 |
Schumacker PT. SIRT3 controls cancer metabolic reprogramming by regulating ROS and HIF. Cancer Cell. 19: 299-300. PMID 21397853 DOI: 10.1016/J.Ccr.2011.03.001 |
0.38 |
|
| 2011 |
Loor G, Kondapalli J, Iwase H, Chandel NS, Waypa GB, Guzy RD, Vanden Hoek TL, Schumacker PT. Mitochondrial oxidant stress triggers cell death in simulated ischemia-reperfusion. Biochimica Et Biophysica Acta. 1813: 1382-94. PMID 21185334 DOI: 10.1016/J.Bbamcr.2010.12.008 |
0.765 |
|
| 2011 |
Budinger GR, Mutlu GM, Urich D, Soberanes S, Buccellato LJ, Hawkins K, Chiarella SE, Radigan KA, Eisenbart J, Agrawal H, Berkelhamer S, Hekimi S, Zhang J, Perlman H, Schumacker PT, et al. Epithelial cell death is an important contributor to oxidant-mediated acute lung injury. American Journal of Respiratory and Critical Care Medicine. 183: 1043-54. PMID 20959557 DOI: 10.1164/Rccm.201002-0181Oc |
0.32 |
|
| 2011 |
Wedgwood S, Lakshminrusimha S, Fukai T, Russell JA, Schumacker PT, Steinhorn RH. Hydrogen peroxide regulates extracellular superoxide dismutase activity and expression in neonatal pulmonary hypertension. Antioxidants & Redox Signaling. 15: 1497-506. PMID 20919937 DOI: 10.1089/Ars.2010.3630 |
0.385 |
|
| 2010 |
Guzman JN, Sanchez-Padilla J, Wokosin D, Kondapalli J, Ilijic E, Schumacker PT, Surmeier DJ. Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1. Nature. 468: 696-700. PMID 21068725 DOI: 10.1038/Nature09536 |
0.36 |
|
| 2010 |
Loor G, Kondapalli J, Schriewer JM, Chandel NS, Vanden Hoek TL, Schumacker PT. Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis. Free Radical Biology & Medicine. 49: 1925-36. PMID 20937380 DOI: 10.1016/J.Freeradbiomed.2010.09.021 |
0.454 |
|
| 2010 |
Farrow KN, Wedgwood S, Lee KJ, Czech L, Gugino SF, Lakshminrusimha S, Schumacker PT, Steinhorn RH. Mitochondrial oxidant stress increases PDE5 activity in persistent pulmonary hypertension of the newborn. Respiratory Physiology & Neurobiology. 174: 272-81. PMID 20804862 DOI: 10.1016/J.Resp.2010.08.018 |
0.458 |
|
| 2010 |
Schumacker PT. Is enough oxygen too much? Critical Care (London, England). 14: 191. PMID 20804573 DOI: 10.1186/Cc9201 |
0.379 |
|
| 2010 |
Waypa GB, Schumacker PT. Hypoxia-induced changes in pulmonary and systemic vascular resistance: where is the O2 sensor? Respiratory Physiology & Neurobiology. 174: 201-11. PMID 20713189 DOI: 10.1016/J.Resp.2010.08.007 |
0.463 |
|
| 2010 |
Jung HJ, Shim JS, Lee J, Song YM, Park KC, Choi SH, Kim ND, Yoon JH, Mungai PT, Schumacker PT, Kwon HJ. Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing. The Journal of Biological Chemistry. 285: 11584-95. PMID 20145250 DOI: 10.1074/Jbc.M109.087809 |
0.801 |
|
| 2010 |
Schumacker PT. A tumor suppressor SIRTainty. Cancer Cell. 17: 5-6. PMID 20129243 DOI: 10.1016/J.Ccr.2009.12.032 |
0.344 |
|
| 2010 |
Waypa GB, Marks JD, Guzy R, Mungai PT, Schriewer J, Dokic D, Schumacker PT. Hypoxia triggers subcellular compartmental redox signaling in vascular smooth muscle cells. Circulation Research. 106: 526-35. PMID 20019331 DOI: 10.1161/Circresaha.109.206334 |
0.804 |
|
| 2010 |
Desireddi JR, Farrow KN, Marks JD, Waypa GB, Schumacker PT. Hypoxia increases ROS signaling and cytosolic Ca(2+) in pulmonary artery smooth muscle cells of mouse lungs slices. Antioxidants & Redox Signaling. 12: 595-602. PMID 19747064 DOI: 10.1089/Ars.2009.2862 |
0.456 |
|
| 2010 |
Chi AY, Waypa GB, Mungai PT, Schumacker PT. Prolonged hypoxia increases ROS signaling and RhoA activation in pulmonary artery smooth muscle and endothelial cells. Antioxidants & Redox Signaling. 12: 603-10. PMID 19747063 DOI: 10.1089/Ars.2009.2861 |
0.798 |
|
| 2009 |
Panduri V, Liu G, Surapureddi S, Kondapalli J, Soberanes S, Souza-Pinto NCd, Bohr VA, Budinger GRS, Schumacker PT, Weitzman SA, Kamp DW. Role of mitochondrial hOGG1 and aconitase in oxidant-induced lung epithelial cell apoptosis Free Radical Biology and Medicine. 47: 750-759. PMID 19524665 DOI: 10.1016/J.Freeradbiomed.2009.06.010 |
0.439 |
|
| 2009 |
Soberanes S, Urich D, Baker CM, Burgess Z, Chiarella SE, Bell EL, Ghio AJ, De Vizcaya-Ruiz A, Liu J, Ridge KM, Kamp DW, Chandel NS, Schumacker PT, Mutlu GM, Budinger GR. Mitochondrial complex III-generated oxidants activate ASK1 and JNK to induce alveolar epithelial cell death following exposure to particulate matter air pollution. The Journal of Biological Chemistry. 284: 2176-86. PMID 19033436 DOI: 10.1074/Jbc.M808844200 |
0.461 |
|
| 2009 |
Klimova TA, Bell EL, Shroff EH, Weinberg FD, Snyder CM, Dimri GP, Schumacker PT, Budinger GR, Chandel NS. Hyperoxia-induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 783-94. PMID 18948382 DOI: 10.1096/Fj.08-114256 |
0.465 |
|
| 2009 |
Bhalla S, Gordon LI, Singh A, Ahmed S, Dokic D, James C, Schumacker PT, Evens AM. PX-478, a Novel Small Molecule Inhibitor of Hypoxia Inducible Factor-1 (HIF-1) Downregulates HIF and Induces Cytotoxicity in Diffuse Large B Cell Lymphoma Cells. Blood. 114: 2713-2713. DOI: 10.1182/Blood.V114.22.2713.2713 |
0.352 |
|
| 2009 |
Ahmed S, Evens AM, Bhalla S, Singh A, James C, Yang S, Prachand S, Dokic D, Gascoyne RD, Winter JN, Schumacker PT, Gordon LI. Hypoxia Inducible Factor 1á (HIF-1á) Regulates CD20 Expression in Lymphoma Cells: Possible Implications for Rituximab Based Therapy in Diffuse Large B Cell Lymphoma (DLBCL). Blood. 114: 1698-1698. DOI: 10.1182/Blood.V114.22.1698.1698 |
0.333 |
|
| 2008 |
Ulanovskaya OA, Janjic J, Suzuki M, Sabharwal SS, Schumacker PT, Kron SJ, Kozmin SA. Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide. Nature Chemical Biology. 4: 418-24. PMID 18516048 DOI: 10.1038/Nchembio.94 |
0.346 |
|
| 2008 |
Evens AM, Schumacker PT, Helenowski IB, Singh AT, Dokic D, Keswani A, Kordeluk E, Raji A, Winter JN, Jovanovic BD, Holmgren A, Nelson BP, Gordon LI. Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family. British Journal of Haematology. 141: 676-80. PMID 18422776 DOI: 10.1111/J.1365-2141.2008.07093.X |
0.317 |
|
| 2008 |
Loor G, Schumacker PT. Role of hypoxia-inducible factor in cell survival during myocardial ischemia-reperfusion. Cell Death & Differentiation. 15: 686-690. PMID 18259200 DOI: 10.1038/Cdd.2008.13 |
0.431 |
|
| 2008 |
Vadász I, Dada LA, Briva A, Trejo HE, Welch LC, Chen J, Tóth PT, Lecuona E, Witters LA, Schumacker PT, Chandel NS, Seeger W, Sznajder JI. AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis. The Journal of Clinical Investigation. 118: 752-62. PMID 18188452 DOI: 10.1172/Jci29723 |
0.328 |
|
| 2008 |
Waypa GB, Schumacker PT. Oxygen sensing in hypoxic pulmonary vasoconstriction: using new tools to answer an age-old question. Experimental Physiology. 93: 133-8. PMID 17993507 DOI: 10.1113/Expphysiol.2007.041236 |
0.503 |
|
| 2008 |
Farrow KN, Groh BS, Schumacker PT, Lakshminrusimha S, Czech L, Gugino SF, Russell JA, Steinhorn RH. Hyperoxia increases phosphodiesterase 5 expression and activity in ovine fetal pulmonary artery smooth muscle cells. Circulation Research. 102: 226-33. PMID 17991881 DOI: 10.1161/Circresaha.107.161463 |
0.427 |
|
| 2008 |
Guzy RD, Sharma B, Bell E, Chandel NS, Schumacker PT. Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis. Molecular and Cellular Biology. 28: 718-31. PMID 17967865 DOI: 10.1128/Mcb.01338-07 |
0.732 |
|
| 2008 |
Evens AM, Sehn LH, Farinha P, Schumacker PT, Raji A, Lu Y, Nelson BP, Gascoyne RD, Gordon LI. Expression of Hypoxia-Inducible Factor (HIF) Is An Independent Favorable Prognostic Factor in Diffuse Large B-Cell Lymphoma (DLBCL) Treated with R-CHOP Blood. 112: 479-479. DOI: 10.1182/Blood.V112.11.479.479 |
0.321 |
|
| 2007 |
Iwase H, Robin E, Guzy RD, Mungai PT, Vanden Hoek TL, Chandel NS, Levraut J, Schumacker PT. Nitric oxide during ischemia attenuates oxidant stress and cell death during ischemia and reperfusion in cardiomyocytes. Free Radical Biology & Medicine. 43: 590-9. PMID 17640569 DOI: 10.1016/J.Freeradbiomed.2007.05.017 |
0.785 |
|
| 2007 |
Guzy RD, Mack MM, Schumacker PT. Mitochondrial complex III is required for hypoxia-induced ROS production and gene transcription in yeast. Antioxidants & Redox Signaling. 9: 1317-28. PMID 17627464 DOI: 10.1089/Ars.2007.1708 |
0.753 |
|
| 2007 |
Tracy K, Dibling BC, Spike BT, Knabb JR, Schumacker P, Macleod KF. BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Molecular and Cellular Biology. 27: 6229-42. PMID 17576813 DOI: 10.1128/Mcb.02246-06 |
0.377 |
|
| 2007 |
Bell EL, Klimova TA, Eisenbart J, Schumacker PT, Chandel NS. Mitochondrial reactive oxygen species trigger hypoxia-inducible factor-dependent extension of the replicative life span during hypoxia. Molecular and Cellular Biology. 27: 5737-45. PMID 17562866 DOI: 10.1128/Mcb.02265-06 |
0.454 |
|
| 2007 |
Robin E, Guzy RD, Loor G, Iwase H, Waypa GB, Marks JD, Hoek TL, Schumacker PT. Oxidant stress during simulated ischemia primes cardiomyocytes for cell death during reperfusion. The Journal of Biological Chemistry. 282: 19133-43. PMID 17488710 DOI: 10.1074/Jbc.M701917200 |
0.75 |
|
| 2007 |
Subramanian RM, Chandel N, Budinger GR, Schumacker PT. Hypoxic conformance of metabolism in primary rat hepatocytes: a model of hepatic hibernation. Hepatology (Baltimore, Md.). 45: 455-64. PMID 17366663 DOI: 10.1002/Hep.21462 |
0.443 |
|
| 2007 |
Bhalla S, Singh AT, Prachand S, Haque Q, O’Halloran TV, Winter JN, Schumacker PT, Platanias LC, Gordon LI, Evens AM. Arsenic Trioxide (As2O3) Mediated Cell Death in Hodgkin Lymphoma (HL) and Non-Hodgkin Lymphoma (NHL): Investigation of Reactive Oxygen Species (ROS), Caspase, and MAP Kinase Signaling Pathways. Blood. 110: 2576-2576. DOI: 10.1182/Blood.V110.11.2576.2576 |
0.377 |
|
| 2007 |
Panduri V, Surapureddi S, Soberanes S, Weitzman SA, Budinger S, Schumacker P, Kamp DW. 13 A Mitochondria-Targeted Dna Repair Enzyme, Hogg-1, Prevents Oxidant-Induced A549 Cell Apoptosis By Preserving Mitochondrial Aconitase. Journal of Investigative Medicine. 55. DOI: 10.1136/Jim-55-02-13 |
0.421 |
|
| 2007 |
Loor G, Kondapalli J, Sharma B, Guzy R, Schumacker P. Mechanisms of cell death in oxidant stress and ischemia-reperfusion injury The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A448-C |
0.71 |
|
| 2007 |
Loor G, Kondalpalli J, Dokic D, Sharma B, Mungai P, Schumacker P. Cardiomyocyte death in ischemia-reperfusion is mediated by opening of the mitochondrial permeability transition pore: Role of oxidant stress during ischemia Journal of the American College of Surgeons. 205: S21-S22. DOI: 10.1016/J.Jamcollsurg.2007.06.045 |
0.782 |
|
| 2006 |
Waypa GB, Guzy R, Mungai PT, Mack MM, Marks JD, Roe MW, Schumacker PT. Increases in mitochondrial reactive oxygen species trigger hypoxia-induced calcium responses in pulmonary artery smooth muscle cells. Circulation Research. 99: 970-8. PMID 17008601 DOI: 10.1161/01.Res.0000247068.75808.3F |
0.809 |
|
| 2006 |
Schumacker PT. Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell. 10: 175-6. PMID 16959608 DOI: 10.1016/J.Ccr.2006.08.015 |
0.408 |
|
| 2006 |
Guzy RD, Schumacker PT. Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia. Experimental Physiology. 91: 807-19. PMID 16857720 DOI: 10.1113/Expphysiol.2006.033506 |
0.779 |
|
| 2006 |
Waypa GB, Schumacker PT. Role for mitochondrial reactive oxygen species in hypoxic pulmonary vasoconstriction. Novartis Foundation Symposium. 272: 176-92; discussion 1. PMID 16686436 DOI: 10.1002/9780470035009.Ch14 |
0.487 |
|
| 2006 |
Shao ZH, Hsu CW, Chang WT, Waypa GB, Li J, Li D, Li CQ, Anderson T, Qin Y, Schumacker PT, Becker LB, Hoek TLV. Cytotoxicity induced by grape seed proanthocyanidins: role of nitric oxide. Cell Biology and Toxicology. 22: 149-158. PMID 16555001 DOI: 10.1007/S10565-006-0052-X |
0.389 |
|
| 2006 |
Ali MH, Mungai PT, Schumacker PT. Stretch-induced phosphorylation of focal adhesion kinase in endothelial cells: role of mitochondrial oxidants. American Journal of Physiology. Lung Cellular and Molecular Physiology. 291: L38-45. PMID 16510472 DOI: 10.1152/Ajplung.00287.2004 |
0.792 |
|
| 2006 |
Singh A, Prachand S, Evens AM, Schumacker P, Gordon LI. Motexafin Gadolinium (Mgd), a Redox Stress Inducer, Lowers p53 Protein but Not Message in Lymphoma Cell Lines: Mechanisms of Reactive Oxygen Species (ROS)-Mediated Apoptosis in Lymphoma. Blood. 108: 2393-2393. DOI: 10.1182/Blood.V108.11.2393.2393 |
0.371 |
|
| 2005 |
Schumacker PT. Hypoxia-inducible factor-1 (HIF-1). Critical Care Medicine. 33: S423-5. PMID 16340411 DOI: 10.1097/01.Ccm.0000191716.38566.E0 |
0.352 |
|
| 2005 |
Li D, Marks JD, Schumacker PT, Young RM, Brorson JR. Physiological hypoxia promotes survival of cultured cortical neurons. The European Journal of Neuroscience. 22: 1319-26. PMID 16190887 DOI: 10.1111/J.1460-9568.2005.04335.X |
0.323 |
|
| 2005 |
Guzy RD, Hoyos B, Robin E, Chen H, Liu L, Mansfield KD, Simon MC, Hammerling U, Schumacker PT. Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metabolism. 1: 401-8. PMID 16054089 DOI: 10.1016/J.Cmet.2005.05.001 |
0.754 |
|
| 2005 |
Mansfield KD, Guzy RD, Pan Y, Young RM, Cash TP, Schumacker PT, Simon MC. Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-alpha activation. Cell Metabolism. 1: 393-9. PMID 16054088 DOI: 10.1016/J.Cmet.2005.05.003 |
0.74 |
|
| 2005 |
Waypa GB, Schumacker PT. Hypoxic pulmonary vasoconstriction: redox events in oxygen sensing. Journal of Applied Physiology (Bethesda, Md. : 1985). 98: 404-14. PMID 15591310 DOI: 10.1152/Japplphysiol.00722.2004 |
0.473 |
|
| 2004 |
Kweon GR, Marks JD, Krencik R, Leung EH, Schumacker PT, Hyland K, Kang UJ. Distinct mechanisms of neurodegeneration induced by chronic complex I inhibition in dopaminergic and non-dopaminergic cells. The Journal of Biological Chemistry. 279: 51783-92. PMID 15469939 DOI: 10.1074/Jbc.M407336200 |
0.406 |
|
| 2004 |
Shao ZH, Vanden Hoek TL, Li CQ, Schumacker PT, Becker LB, Chan KC, Qin Y, Yin JJ, Yuan CS. Synergistic effect of Scutellaria baicalensis and grape seed proanthocyanidins on scavenging reactive oxygen species in vitro. The American Journal of Chinese Medicine. 32: 89-95. PMID 15154288 DOI: 10.1142/S0192415X04001722 |
0.377 |
|
| 2004 |
Ali MH, Pearlstein DP, Mathieu CE, Schumacker PT. Mitochondrial requirement for endothelial responses to cyclic strain: implications for mechanotransduction. American Journal of Physiology. Lung Cellular and Molecular Physiology. 287: L486-96. PMID 15090367 DOI: 10.1152/Ajplung.00389.2003 |
0.394 |
|
| 2004 |
Shao ZH, Xie JT, Vanden Hoek TL, Mehendale S, Aung H, Li CQ, Qin Y, Schumacker PT, Becker LB, Yuan CS. Antioxidant effects of American ginseng berry extract in cardiomyocytes exposed to acute oxidant stress. Biochimica Et Biophysica Acta. 1670: 165-71. PMID 14980443 DOI: 10.1016/J.Bbagen.2003.12.001 |
0.423 |
|
| 2003 |
Shao ZH, Vanden Hoek TL, Xie J, Wojcik K, Chan KC, Li CQ, Hamann K, Qin Y, Schumacker PT, Becker LB, Yuan CS. Grape seed proanthocyanidins induce pro-oxidant toxicity in cardiomyocytes. Cardiovascular Toxicology. 3: 331-9. PMID 14734830 DOI: 10.1385/Ct:3:4:331 |
0.407 |
|
| 2003 |
Schumacker PT. Current paradigms in cellular oxygen sensing. Advances in Experimental Medicine and Biology. 543: 57-71. PMID 14713114 DOI: 10.1007/978-1-4419-8997-0_5 |
0.459 |
|
| 2003 |
Shao ZH, Becker LB, Vanden Hoek TL, Schumacker PT, Li CQ, Zhao D, Wojcik K, Anderson T, Qin Y, Dey L, Yuan CS. Grape seed proanthocyanidin extract attenuates oxidant injury in cardiomyocytes. Pharmacological Research. 47: 463-9. PMID 12741998 DOI: 10.1016/S1043-6618(03)00041-0 |
0.394 |
|
| 2003 |
Levraut J, Iwase H, Shao ZH, Vanden Hoek TL, Schumacker PT. Cell death during ischemia: relationship to mitochondrial depolarization and ROS generation. American Journal of Physiology. Heart and Circulatory Physiology. 284: H549-58. PMID 12388276 DOI: 10.1152/Ajpheart.00708.2002 |
0.444 |
|
| 2003 |
Lebuffe G, Schumacker PT, Shao ZH, Anderson T, Iwase H, Vanden Hoek TL. ROS and NO trigger early preconditioning: relationship to mitochondrial KATP channel. American Journal of Physiology. Heart and Circulatory Physiology. 284: H299-308. PMID 12388274 DOI: 10.1152/Ajpheart.00706.2002 |
0.392 |
|
| 2003 |
Schumacker PT. Oxygen Delivery and Consumption Transfusion Alternatives in Transfusion Medicine. 5: 9-9. DOI: 10.1111/J.1778-428X.2003.Tb00308.X |
0.345 |
|
| 2002 |
Schumacker PT. Angiotensin II signaling in the brain: compartmentalization of redox signaling? Circulation Research. 91: 982-4. PMID 12456482 DOI: 10.1161/01.Res.0000045655.34731.B6 |
0.36 |
|
| 2002 |
Waypa GB, Marks JD, Mack MM, Boriboun C, Mungai PT, Schumacker PT. Mitochondrial reactive oxygen species trigger calcium increases during hypoxia in pulmonary arterial myocytes. Circulation Research. 91: 719-26. PMID 12386149 DOI: 10.1161/01.Res.0000036751.04896.F1 |
0.802 |
|
| 2002 |
Schumacker PT. Hypoxia, anoxia, and O2 sensing: the search continues. American Journal of Physiology. Lung Cellular and Molecular Physiology. 283: L918-21. PMID 12376344 DOI: 10.1152/Ajplung.00205.2002 |
0.346 |
|
| 2002 |
Waypa GB, Schumacker PT. O(2) sensing in hypoxic pulmonary vasoconstriction: the mitochondrial door re-opens. Respiratory Physiology & Neurobiology. 132: 81-91. PMID 12126697 DOI: 10.1016/S1569-9048(02)00051-4 |
0.509 |
|
| 2002 |
Kulisz A, Chen N, Chandel NS, Shao Z, Schumacker PT. Mitochondrial ROS initiate phosphorylation of p38 MAP kinase during hypoxia in cardiomyocytes. American Journal of Physiology. Lung Cellular and Molecular Physiology. 282: L1324-9. PMID 12003789 DOI: 10.1152/Ajplung.00326.2001 |
0.47 |
|
| 2002 |
Pearlstein DP, Ali MH, Mungai PT, Hynes KL, Gewertz BL, Schumacker PT. Role of mitochondrial oxidant generation in endothelial cell responses to hypoxia. Arteriosclerosis, Thrombosis, and Vascular Biology. 22: 566-73. PMID 11950692 DOI: 10.1161/01.Atv.0000012262.76205.6A |
0.789 |
|
| 2002 |
Shao ZH, Vanden Hoek TL, Qin Y, Becker LB, Schumacker PT, Li CQ, Dey L, Barth E, Halpern H, Rosen GM, Yuan CS. Baicalein attenuates oxidant stress in cardiomyocytes. American Journal of Physiology. Heart and Circulatory Physiology. 282: H999-H1006. PMID 11834498 DOI: 10.1152/Ajpheart.00163.2001 |
0.459 |
|
| 2001 |
Chandel NS, Schumacker PT, Arch RH. Reactive oxygen species are downstream products of TRAF-mediated signal transduction. The Journal of Biological Chemistry. 276: 42728-36. PMID 11559697 DOI: 10.1074/Jbc.M103074200 |
0.445 |
|
| 2001 |
Waypa GB, Chandel NS, Schumacker PT. Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing. Circulation Research. 88: 1259-66. PMID 11420302 DOI: 10.1161/Hh1201.091960 |
0.448 |
|
| 2001 |
Yao Z, McPherson BC, Liu H, Shao Z, Li C, Qin Y, Hoek TLV, Becker LB, Schumacker PT. Signal transduction of flumazenil-induced preconditioning in myocytes American Journal of Physiology-Heart and Circulatory Physiology. 280. PMID 11179070 DOI: 10.1152/Ajpheart.2001.280.3.H1249 |
0.345 |
|
| 2001 |
Shao ZH, Li CQ, Becker LB, Hoek TLV, Schumacker PT, Attele AS, Zhang L, Xie JT, Yuan CS. Qian-Kun-Nin, a Chinese herbal medicine formulation, attenuates mitochondrial oxidant stress in cardiomyocytes Journal of Ethnopharmacology. 74: 63-68. PMID 11137349 DOI: 10.1016/S0378-8741(00)00343-3 |
0.468 |
|
| 2000 |
Chandel NS, Vander Heiden MG, Thompson CB, Schumacker PT. Redox regulation of p53 during hypoxia Oncogene. 19: 3840-3848. PMID 10951577 DOI: 10.1038/Sj.Onc.1203727 |
0.447 |
|
| 2000 |
Chandel NS, Trzyna WC, McClintock DS, Schumacker PT. Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin. Journal of Immunology (Baltimore, Md. : 1950). 165: 1013-21. PMID 10878378 DOI: 10.4049/Jimmunol.165.2.1013 |
0.333 |
|
| 2000 |
Chandel NS, McClintock DS, Feliciano CE, Wood TM, Melendez JA, Rodriguez AM, Schumacker PT. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. The Journal of Biological Chemistry. 275: 25130-8. PMID 10833514 DOI: 10.1074/Jbc.M001914200 |
0.473 |
|
| 2000 |
Chandel NS, Schumacker PT. Cellular oxygen sensing by mitochondria: old questions, new insight. Journal of Applied Physiology (Bethesda, Md. : 1985). 88: 1880-9. PMID 10797153 DOI: 10.1152/Jappl.2000.88.5.1880 |
0.45 |
|
| 2000 |
Vander Heiden MG, Chandel NS, Li XX, Schumacker PT, Colombini M, Thompson CB. Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival. Proceedings of the National Academy of Sciences of the United States of America. 97: 4666-71. PMID 10781072 DOI: 10.1073/Pnas.090082297 |
0.362 |
|
| 2000 |
Hoek TLV, Becker LB, Shao ZH, Li CQ, Schumacker PT. Preconditioning in Cardiomyocytes Protects by Attenuating Oxidant Stress at Reperfusion Circulation Research. 86: 541-548. PMID 10720416 DOI: 10.1161/01.Res.86.5.541 |
0.416 |
|
| 1999 |
Yao Z, Tong J, Tan X, Li C, Shao Z, Kim WC, Vanden Hoek TL, Becker LB, Head CA, Schumacker PT. Role of reactive oxygen species in acetylcholine-induced preconditioning in cardiomyocytes. American Journal of Physiology. Heart and Circulatory Physiology. 277: H2504-H2509. PMID 29592292 DOI: 10.1152/Ajpheart.1999.277.6.H2504 |
0.361 |
|
| 1999 |
Becker LB, Vanden Hoek TL, Shao ZH, Li CQ, Schumacker PT. Generation of superoxide in cardiomyocytes during ischemia before reperfusion. American Journal of Physiology. Heart and Circulatory Physiology. 277: H2240-H2246. PMID 29592283 DOI: 10.1152/Ajpheart.1999.277.6.H2240 |
0.356 |
|
| 1999 |
Ali MH, Schlidt SA, Chandel NS, Hynes KL, Schumacker PT, Gewertz BL. Endothelial permeability and IL-6 production during hypoxia: role of ROS in signal transduction. The American Journal of Physiology. 277: L1057-65. PMID 10564193 DOI: 10.1152/Ajplung.1999.277.5.L1057 |
0.418 |
|
| 1999 |
Shao ZH, Li CQ, Hoek TLV, Becker LB, Schumacker PT, Wu JA, Attele AS, Yuan CS. Extract from Scutellaria baicalensis Georgi Attenuates Oxidant Stress in Cardiomyocytes Journal of Molecular and Cellular Cardiology. 31: 1885-1895. PMID 10525426 DOI: 10.1006/Jmcc.1999.1021 |
0.427 |
|
| 1999 |
Chandel NS, Schumacker PT. Cells depleted of mitochondrial DNA (rho0) yield insight into physiological mechanisms. Febs Letters. 454: 173-6. PMID 10431801 DOI: 10.1016/S0014-5793(99)00783-8 |
0.467 |
|
| 1999 |
Vander Heiden MG, Chandel NS, Schumacker PT, Thompson CB. Bcl-x(L) prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange Molecular Cell. 3: 159-167. PMID 10078199 DOI: 10.1016/S1097-2765(00)80307-X |
0.414 |
|
| 1999 |
Brorson JR, Schumacker PT, Zhang H. Nitric Oxide Acutely Inhibits Neuronal Energy Production The Journal of Neuroscience. 19: 147-158. DOI: 10.1523/Jneurosci.19-01-00147.1999 |
0.397 |
|
| 1998 |
Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC, Schumacker PT. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proceedings of the National Academy of Sciences of the United States of America. 95: 11715-20. PMID 9751731 DOI: 10.1073/Pnas.95.20.11715 |
0.514 |
|
| 1998 |
Hoek TLV, Becker LB, Shao Z, Li C, Schumacker PT. Reactive Oxygen Species Released from Mitochondria during Brief Hypoxia Induce Preconditioning in Cardiomyocytes Journal of Biological Chemistry. 273: 18092-18098. PMID 9660766 DOI: 10.1074/Jbc.273.29.18092 |
0.521 |
|
| 1998 |
Duranteau J, Chandel NS, Kulisz A, Shao Z, Schumacker PT. Intracellular signaling by reactive oxygen species during hypoxia in cardiomyocytes. The Journal of Biological Chemistry. 273: 11619-24. PMID 9565580 DOI: 10.1074/Jbc.273.19.11619 |
0.508 |
|
| 1998 |
Schumacker PT. Oxygen supply dependency in critical illness: an evolving understanding. Intensive Care Medicine. 24: 97-99. PMID 9539063 DOI: 10.1007/S001340050527 |
0.345 |
|
| 1998 |
Budinger GR, Duranteau J, Chandel NS, Schumacker PT. Hibernation during hypoxia in cardiomyocytes. Role of mitochondria as the O2 sensor. The Journal of Biological Chemistry. 273: 3320-6. PMID 9452449 DOI: 10.1074/Jbc.273.6.3320 |
0.443 |
|
| 1997 |
Vander Heiden MG, Chandel NS, Williamson EK, Schumacker PT, Thompson CB. Bcl-x(L) regulates the membrane potential and volume homeostasis of mitochondria Cell. 91: 627-637. PMID 9393856 DOI: 10.1016/S0092-8674(00)80450-X |
0.4 |
|
| 1997 |
Hoek TLV, Li C, Shao Z, Schumacker PT, Becker LB. Significant Levels of Oxidants Are Generated by Isolated Cardiomyocytes During Ischemia Prior to Reperfusion Journal of Molecular and Cellular Cardiology. 29: 2571-2583. PMID 9299379 DOI: 10.1006/Jmcc.1997.0497 |
0.438 |
|
| 1997 |
Hoek TLV, Shao Z, Li C, Schumacker PT, Becker LB. Mitochondrial Electron Transport can Become a Significant Source of Oxidative Injury in Cardiomyocytes Journal of Molecular and Cellular Cardiology. 29: 2441-2450. PMID 9299367 DOI: 10.1006/Jmcc.1997.0481 |
0.458 |
|
| 1997 |
Chandel NS, Budinger GR, Choe SH, Schumacker PT. Cellular respiration during hypoxia. Role of cytochrome oxidase as the oxygen sensor in hepatocytes. The Journal of Biological Chemistry. 272: 18808-16. PMID 9228055 DOI: 10.1074/Jbc.272.30.18808 |
0.455 |
|
| 1996 |
Budinger GR, Chandel N, Shao ZH, Li CQ, Melmed A, Becker LB, Schumacker PT. Cellular energy utilization and supply during hypoxia in embryonic cardiac myocytes. The American Journal of Physiology. 270: L44-53. PMID 8772526 DOI: 10.1152/Ajplung.1996.270.1.L44 |
0.398 |
|
| 1996 |
Chandel NS, Budinger GR, Schumacker PT. Molecular oxygen modulates cytochrome c oxidase function. The Journal of Biological Chemistry. 271: 18672-7. PMID 8702521 DOI: 10.1074/Jbc.271.31.18672 |
0.383 |
|
| 1995 |
Schumacker PT, Kazaglis J, Connolly HV, Samsel RW, O'Connor MF, Umans JG. Systemic and gut O2 extraction during endotoxemia. Role of nitric oxide synthesis. American Journal of Respiratory and Critical Care Medicine. 151: 107-15. PMID 7812539 DOI: 10.1164/Ajrccm.151.1.7812539 |
0.376 |
|
| 1995 |
Chandel N, Budinger GR, Kemp RA, Schumacker PT. Inhibition of cytochrome-c oxidase activity during prolonged hypoxia. The American Journal of Physiology. 268: L918-25. PMID 7611433 DOI: 10.1152/Ajplung.1995.268.6.L918 |
0.394 |
|
| 1994 |
Samsel RW, Lewis TH, Sanders WM, Wood LDH, Schumacker PT. The effect of adrenergic agonists on the systemic response to hemorrhage Journal of Critical Care. 9: 25-33. PMID 8199651 DOI: 10.1016/0883-9441(94)90030-2 |
0.355 |
|
| 1994 |
Hershenson MB, Wylam ME, Punjabi N, Umans JG, Schumacker PT, Mitchell RW, Solway J. Exposure of immature rats to hyperoxia increases tracheal smooth muscle stress generation in vitro. Journal of Applied Physiology (Bethesda, Md. : 1985). 76: 743-9. PMID 8175585 DOI: 10.1152/Jappl.1994.76.2.743 |
0.32 |
|
| 1994 |
Schumacker PT, Soble JS, Feldman T. Oxygen delivery and uptake relationships in patients with aortic stenosis American Journal of Respiratory and Critical Care Medicine. 149: 1123-1131. PMID 8173751 DOI: 10.1164/Ajrccm.149.5.8173751 |
0.32 |
|
| 1994 |
Maginniss LA, Connolly H, Samsel RW, Schumacker PT. Adrenergic vasoconstriction augments tissue O2 extraction during reductions in O2 delivery Journal of Applied Physiology. 76: 1454-1461. PMID 8045819 DOI: 10.1152/Jappl.1994.76.4.1454 |
0.3 |
|
| 1993 |
Umans JG, Wylam ME, Samsel RW, Edwards J, Schumacker PT. Effects of endotoxin in vivo on endothelial and smooth-muscle function in rabbit and rat aorta The American Review of Respiratory Disease. 148: 1638-1645. PMID 8256913 DOI: 10.1164/Ajrccm/148.6_Pt_1.1638 |
0.319 |
|
| 1993 |
Schumacker PT, Chandel N, Agusti AG. Oxygen conformance of cellular respiration in hepatocytes. The American Journal of Physiology. 265: L395-402. PMID 8238374 DOI: 10.1152/Ajplung.1993.265.4.L395 |
0.384 |
|
| 1989 |
Schumacker PT, Samsel RW. Analysis of oxygen delivery and uptake relationships in the Krogh tissue model Journal of Applied Physiology. 67: 1234-1244. PMID 2793716 DOI: 10.1152/Jappl.1989.67.3.1234 |
0.323 |
|
| 1989 |
Schumacker PT, Samsel RW. Oxygen delivery and uptake by peripheral tissues: physiology and pathophysiology. Critical Care Clinics. 5: 255-269. DOI: 10.1016/S0749-0704(18)30435-4 |
0.332 |
|
| 1988 |
Long GR, Nelson DP, Sznajder JL, Wood LDH, Schumacker PT. Systemic oxygen delivery and consumption during acute lung injury in dogs Journal of Critical Care. 3: 249-255. DOI: 10.1016/0883-9441(88)90109-8 |
0.332 |
|
| 1987 |
Nelson DP, Beyer C, Samsel RW, Wood LDH, Schumacker PT. Pathological supply dependence of O2 uptake during bacteremia in dogs Journal of Applied Physiology. 63: 1487-1492. PMID 3693185 DOI: 10.1152/Jappl.1987.63.4.1487 |
0.305 |
|
| 1987 |
Schumacker PT, Rowland J, Saltz S, Nelson DP, Wood LDH. Effects of hyperthermia and hypothermia on oxygen extraction by tissues during hypovolemia Journal of Applied Physiology. 63: 1246-1252. PMID 3654470 DOI: 10.1152/Jappl.1987.63.3.1246 |
0.314 |
|
| 1987 |
Schumacker PT, Cain SM. The concept of a critical oxygen delivery. Intensive Care Medicine. 13: 223-9. PMID 3301969 DOI: 10.1007/Bf00265110 |
0.363 |
|
| 1984 |
Schumacker PT, Wood LDH. Limitations of aerobic metabolism in critical illness. Chest. 85: 453-454. PMID 6705570 DOI: 10.1378/Chest.85.4.453 |
0.352 |
|
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