| Year |
Citation |
Score |
| 2024 |
Hisey JA, Radchenko EA, Mandel NH, McGinty RJ, Matos-Rodrigues G, Rastokina A, Masnovo C, Ceschi S, Hernandez A, Nussenzweig A, Mirkin SM. Pathogenic CANVAS (AAGGG)n repeats stall DNA replication due to the formation of alternative DNA structures. Nucleic Acids Research. PMID 38381906 DOI: 10.1093/nar/gkae124 |
0.38 |
|
| 2023 |
Zong D, Koussa NC, Cornwell JA, Pankajam AV, Kruhlak MJ, Wong N, Chari R, Cappell SD, Nussenzweig A. Comprehensive mapping of cell fates in microsatellite unstable cancer cells supports dual targeting of WRN and ATR. Genes & Development. 37: 913-928. PMID 37932011 DOI: 10.1101/gad.351085.123 |
0.347 |
|
| 2023 |
Matos-Rodrigues G, Hisey JA, Nussenzweig A, Mirkin SM. Detection of alternative DNA structures and its implications for human disease. Molecular Cell. 83: 3622-3641. PMID 37863029 DOI: 10.1016/j.molcel.2023.08.018 |
0.433 |
|
| 2023 |
Zhang L, Hsu JI, Braekeleer ED, Chen CW, Patel TD, Urya H, Guzman AG, Martell AG, Waldvogel SM, Tovy A, Callen E, Murdaugh R, Richard R, Jansen S, Vissers L, ... ... Nussenzweig A, et al. is a synthetic lethal target in -mutant leukemia cells. Biorxiv : the Preprint Server For Biology. PMID 37693622 DOI: 10.1101/2023.08.31.555634 |
0.365 |
|
| 2023 |
Zong D, Koussa NC, Cornwell JA, Pankajam AV, Kruhlak MJ, Wong N, Chari R, Cappell SD, Nussenzweig A. Comprehensive mapping of cell fates in microsatellite unstable cancer cells support dual targeting of WRN and ATR. Biorxiv : the Preprint Server For Biology. PMID 37662356 DOI: 10.1101/2023.07.28.550976 |
0.363 |
|
| 2023 |
Hisey JA, Radchenko EA, Ceschi S, Rastokina A, Mandel NH, McGinty RJ, Matos-Rodrigues G, Hernandez A, Nussenzweig A, Mirkin SM. Pathogenic CANVAS (AAGGG) repeats stall DNA replication due to the formation of alternative DNA structures. Biorxiv : the Preprint Server For Biology. PMID 37546920 DOI: 10.1101/2023.07.25.550509 |
0.429 |
|
| 2023 |
Zagelbaum J, Schooley A, Zhao J, Schrank BR, Callen E, Zha S, Gottesman ME, Nussenzweig A, Rabadan R, Dekker J, Gautier J. Author Correction: Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization. Nature Structural & Molecular Biology. PMID 37059902 DOI: 10.1038/s41594-023-00994-w |
0.435 |
|
| 2023 |
Saayman X, Graham E, Nathan WJ, Nussenzweig A, Esashi F. Centromeres as universal hotspots of DNA breakage, driving RAD51-mediated recombination during quiescence. Molecular Cell. PMID 36702125 DOI: 10.1016/j.molcel.2023.01.004 |
0.533 |
|
| 2022 |
Zagelbaum J, Schooley A, Zhao J, Schrank BR, Callen E, Zha S, Gottesman ME, Nussenzweig A, Rabadan R, Dekker J, Gautier J. Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization. Nature Structural & Molecular Biology. PMID 36564591 DOI: 10.1038/s41594-022-00893-6 |
0.483 |
|
| 2022 |
Ciccia A, Greenberg RA, Lees-Miller SP, Nussenzweig A. A genetic roadmap to the response to genotoxic agents in human cells. Faculty Reviews. 11: 35. PMID 36532708 DOI: 10.12703/r-01-0000019 |
0.428 |
|
| 2022 |
Wang D, Wu W, Callen E, Pavani R, Zolnerowich N, Kodali S, Zong D, Wong N, Noriega S, Nathan WJ, Matos-Rodrigues G, Chari R, Kruhlak MJ, Livak F, Ward M, ... ... Nussenzweig A, et al. Active DNA demethylation promotes cell fate specification and the DNA damage response. Science (New York, N.Y.). 378: 983-989. PMID 36454826 DOI: 10.1126/science.add9838 |
0.444 |
|
| 2022 |
Matos-Rodrigues G, van Wietmarschen N, Wu W, Tripathi V, Koussa NC, Pavani R, Nathan WJ, Callen E, Belinky F, Mohammed A, Napierala M, Usdin K, Ansari AZ, Mirkin SM, Nussenzweig A. S1-END-seq reveals DNA secondary structures in human cells. Molecular Cell. PMID 36075220 DOI: 10.1016/j.molcel.2022.08.007 |
0.501 |
|
| 2022 |
Borel V, Boeing S, Van Wietmarschen N, Sridharan S, Hill BR, Ombrato L, Perez-Lloret J, Jackson D, Goldstone R, Boulton SJ, Nussenzweig A, Bellelli R. Disrupted control of origin activation compromises genome integrity upon destabilization of Polε and dysfunction of the TRP53-CDKN1A/P21 axis. Cell Reports. 39: 110871. PMID 35649380 DOI: 10.1016/j.celrep.2022.110871 |
0.361 |
|
| 2022 |
Fowler FC, Chen BR, Zolnerowich N, Wu W, Pavani R, Paiano J, Peart C, Chen Z, Nussenzweig A, Sleckman BP, Tyler JK. DNA-PK promotes DNA end resection at DNA double strand breaks in G cells. Elife. 11. PMID 35575473 DOI: 10.7554/eLife.74700 |
0.462 |
|
| 2022 |
Pommier Y, Nussenzweig A, Takeda S, Austin C. Human topoisomerases and their roles in genome stability and organization. Nature Reviews. Molecular Cell Biology. PMID 35228717 DOI: 10.1038/s41580-022-00452-3 |
0.407 |
|
| 2022 |
Setiaputra D, Escribano-Díaz C, Reinert JK, Sadana P, Zong D, Callen E, Sifri C, Seebacher J, Nussenzweig A, Thomä NH, Durocher D. RIF1 acts in DNA repair through phosphopeptide recognition of 53BP1. Molecular Cell. PMID 35216668 DOI: 10.1016/j.molcel.2022.01.025 |
0.456 |
|
| 2022 |
Caldecott KW, Ward ME, Nussenzweig A. The threat of programmed DNA damage to neuronal genome integrity and plasticity. Nature Genetics. 54: 115-120. PMID 35145299 DOI: 10.1038/s41588-021-01001-y |
0.37 |
|
| 2021 |
Bronder D, Tighe A, Wangsa D, Zong D, Meyer TJ, Wardenaar R, Minshall P, Hirsch D, Heselmeyer-Haddad K, Nelson L, Spierings D, McGrail JC, Cam M, Nussenzweig A, Foijer F, et al. TP53 loss initiates chromosomal instability in fallopian tube epithelial cells. Disease Models & Mechanisms. PMID 34569598 DOI: 10.1242/dmm.049001 |
0.375 |
|
| 2021 |
Paiano J, Zolnerowich N, Wu W, Pavani R, Wang C, Li H, Zheng L, Shen B, Sleckman BP, Chen BR, Nussenzweig A. Role of 53BP1 in end protection and DNA synthesis at DNA breaks. Genes & Development. PMID 34503990 DOI: 10.1101/gad.348667.121 |
0.473 |
|
| 2021 |
Chen BR, Wang Y, Tubbs A, Zong D, Fowler FC, Zolnerowich N, Wu W, Bennett A, Chen CC, Feng W, Nussenzweig A, Tyler JK, Sleckman BP. LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells. Elife. 10. PMID 34477552 DOI: 10.7554/eLife.68466 |
0.474 |
|
| 2021 |
Mei Q, Fitzgerald DM, Liu J, Xia J, Pribis JP, Zhai Y, Nehring RB, Paiano J, Li H, Nussenzweig A, Hastings PJ, Rosenberg SM. Two mechanisms of chromosome fragility at replication-termination sites in bacteria. Science Advances. 7. PMID 34144978 DOI: 10.1126/sciadv.abe2846 |
0.479 |
|
| 2021 |
Zatreanu D, Robinson HMR, Alkhatib O, Boursier M, Finch H, Geo L, Grande D, Grinkevich V, Heald RA, Langdon S, Majithiya J, McWhirter C, Martin NMB, Moore S, Neves J, ... ... Nussenzweig A, et al. Polθ inhibitors elicit BRCA-gene synthetic lethality and target PARP inhibitor resistance. Nature Communications. 12: 3636. PMID 34140467 DOI: 10.1038/s41467-021-23463-8 |
0.437 |
|
| 2021 |
Ramsden DA, Nussenzweig A. Mechanisms driving chromosomal translocations: lost in time and space. Oncogene. 40: 4263-4270. PMID 34103687 DOI: 10.1038/s41388-021-01856-9 |
0.306 |
|
| 2021 |
Shinoda K, Zong D, Callen E, Wu W, Dumitrache LC, Belinky F, Chari R, Wong N, Ishikawa M, Stanlie A, Multhaupt-Buell T, Sharma N, Ozelius L, Ehrlich M, McKinnon PJ, ... Nussenzweig A, et al. The dystonia gene THAP1 controls DNA double-strand break repair choice. Molecular Cell. PMID 33857404 DOI: 10.1016/j.molcel.2021.03.034 |
0.487 |
|
| 2021 |
Wu W, Hill SE, Nathan WJ, Paiano J, Callen E, Wang D, Shinoda K, van Wietmarschen N, Colón-Mercado JM, Zong D, De Pace R, Shih HY, Coon S, Parsadanian M, Pavani R, ... ... Nussenzweig A, et al. Neuronal enhancers are hotspots for DNA single-strand break repair. Nature. PMID 33767446 DOI: 10.1038/s41586-021-03468-5 |
0.45 |
|
| 2021 |
Feldhahn N, Ferretti E, Robbiani DF, Callen E, Deroubaix S, Selleri L, Nussenzweig A, Nussenzweig MC. The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo. The Embo Journal. 40: e107130. PMID 33448440 DOI: 10.15252/embj.2020107130 |
0.47 |
|
| 2021 |
Wong N, John S, Nussenzweig A, Canela A. END-seq: An Unbiased, High-Resolution, and Genome-Wide Approach to Map DNA Double-Strand Breaks and Resection in Human Cells. Methods in Molecular Biology (Clifton, N.J.). 2153: 9-31. PMID 32840769 DOI: 10.1007/978-1-0716-0644-5_2 |
0.567 |
|
| 2020 |
van Wietmarschen N, Sridharan S, Nathan WJ, Tubbs A, Chan EM, Callen E, Wu W, Belinky F, Tripathi V, Wong N, Foster K, Noorbakhsh J, Garimella K, Cruz-Migoni A, Sommers JA, ... ... Nussenzweig A, et al. Repeat expansions confer WRN dependence in microsatellite-unstable cancers. Nature. PMID 32999459 DOI: 10.1038/s41586-020-2769-8 |
0.492 |
|
| 2020 |
Zong D, Oberdoerffer P, Batista PJ, Nussenzweig A. RNA: a double-edged sword in genome maintenance. Nature Reviews. Genetics. PMID 32764716 DOI: 10.1038/S41576-020-0263-7 |
0.376 |
|
| 2020 |
He Y, Ren J, Xu X, Ni K, Schwader A, Finney R, Wang C, Sun L, Klarmann K, Keller J, Tubbs A, Nussenzweig A, Muegge K. Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination. Proceedings of the National Academy of Sciences of the United States of America. PMID 32727902 DOI: 10.1073/Pnas.2004112117 |
0.476 |
|
| 2020 |
Feng X, Tubbs A, Zhang C, Tang M, Sridharan S, Wang C, Jiang D, Su D, Zhang H, Chen Z, Nie L, Xiong Y, Huang M, Nussenzweig A, Chen J. ATR inhibition potentiates ionizing radiation-induced interferon response via cytosolic nucleic acid-sensing pathways. The Embo Journal. e104036. PMID 32484965 DOI: 10.15252/Embj.2019104036 |
0.5 |
|
| 2020 |
Nacson J, Di Marcantonio D, Wang Y, Bernhardy AJ, Clausen E, Hua X, Cai KQ, Martinez E, Feng W, Callén E, Wu W, Gupta GP, Testa JR, Nussenzweig A, Sykes SM, et al. BRCA1 Mutational Complementation Induces Synthetic Viability. Molecular Cell. PMID 32359443 DOI: 10.1016/J.Molcel.2020.04.006 |
0.421 |
|
| 2020 |
Mahgoub M, Paiano J, Bruno M, Wu W, Pathuri S, Zhang X, Ralls S, Cheng X, Nussenzweig A, Macfarlan TS. Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice. Elife. 9. PMID 32352380 DOI: 10.7554/Elife.53360 |
0.533 |
|
| 2020 |
Chu SH, Chabon JR, Matovina CN, Minehart JC, Chen BR, Zhang J, Kumar V, Xiong Y, Callen E, Hung PJ, Feng Z, Koche RP, Liu XS, Chaudhuri J, Nussenzweig A, et al. Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development. Iscience. 23: 100941. PMID 32169821 DOI: 10.1016/J.Isci.2020.100941 |
0.544 |
|
| 2020 |
Sciascia N, Wu W, Zong D, Sun Y, Wong N, John S, Wangsa D, Ried T, Bunting SF, Pommier Y, Nussenzweig A. Suppressing proteasome mediated processing of Topoisomerase II DNA-protein complexes preserves genome integrity. Elife. 9. PMID 32057297 DOI: 10.7554/Elife.53447 |
0.598 |
|
| 2020 |
Paiano J, Wu W, Yamada S, Sciascia N, Callen E, Paola Cotrim A, Deshpande RA, Maman Y, Day A, Paull TT, Nussenzweig A. ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis. Nature Communications. 11: 857. PMID 32051414 DOI: 10.1038/S41467-020-14654-W |
0.45 |
|
| 2020 |
Sciascia N, Wu W, Zong D, Sun Y, Wong N, John S, Wangsa D, Ried T, Bunting SF, Pommier Y, Nussenzweig A. Author response: Suppressing proteasome mediated processing of topoisomerase II DNA-protein complexes preserves genome integrity Elife. DOI: 10.7554/Elife.53447.Sa2 |
0.45 |
|
| 2020 |
Mahgoub M, Paiano J, Bruno M, Wu W, Pathuri S, Zhang X, Ralls S, Cheng X, Nussenzweig A, Macfarlan TS. Author response: Dual histone methyl reader ZCWPW1 facilitates repair of meiotic double strand breaks in male mice Elife. DOI: 10.7554/Elife.53360.Sa2 |
0.415 |
|
| 2019 |
Shinoda K, Maman Y, Canela A, Schatz DG, Livak F, Nussenzweig A. Intra-Vκ Cluster Recombination Shapes the Ig Kappa Locus Repertoire. Cell Reports. 29: 4471-4481.e6. PMID 31875554 DOI: 10.1016/J.Celrep.2019.11.088 |
0.367 |
|
| 2019 |
Eke I, Zong D, Aryankalayil MJ, Sandfort V, Bylicky MA, Rath BH, Graves EE, Nussenzweig A, Coleman CN. 53BP1/RIF1 signaling promotes cell survival after multifractionated radiotherapy. Nucleic Acids Research. PMID 31822909 DOI: 10.1093/Nar/Gkz1139 |
0.413 |
|
| 2019 |
Livak F, Nussenzweig A. One ring to rule them all. Nature. 575: 291-293. PMID 31719691 DOI: 10.1038/D41586-019-03200-4 |
0.501 |
|
| 2019 |
Callen E, Zong D, Wu W, Wong N, Stanlie A, Ishikawa M, Pavani R, Dumitrache LC, Byrum AK, Mendez-Dorantes C, Martinez P, Canela A, Maman Y, Day A, Kruhlak MJ, ... ... Nussenzweig A, et al. 53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination. Molecular Cell. PMID 31653568 DOI: 10.1016/J.Molcel.2019.09.024 |
0.557 |
|
| 2019 |
Yin M, Baslan T, Walker RL, Zhu YJ, Freeland A, Matsukawa T, Sridharan S, Nussenzweig A, Pruitt SC, Lowe SW, Meltzer PS, Aplan PD. A unique mutator phenotype reveals complementary oncogenic lesions leading to acute leukemia. Jci Insight. PMID 31622281 DOI: 10.1172/Jci.Insight.131434 |
0.513 |
|
| 2019 |
Canela A, Maman Y, Huang SN, Wutz G, Tang W, Zagnoli-Vieira G, Callen E, Wong N, Day A, Peters JM, Caldecott KW, Pommier Y, Nussenzweig A. Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity. Molecular Cell. PMID 31202577 DOI: 10.1016/J.Molcel.2019.04.030 |
0.583 |
|
| 2019 |
Zong D, Adam S, Wang Y, Sasanuma H, Callén E, Murga M, Day A, Kruhlak MJ, Wong N, Munro M, Ray Chaudhuri A, Karim B, Xia B, Takeda S, Johnson N, ... ... Nussenzweig A, et al. BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation. Molecular Cell. PMID 30704900 DOI: 10.1016/J.Molcel.2018.12.010 |
0.591 |
|
| 2018 |
Nacson J, Krais JJ, Bernhardy AJ, Clausen E, Feng W, Wang Y, Nicolas E, Cai KQ, Tricarico R, Hua X, DiMarcantonio D, Martinez E, Zong D, Handorf EA, Bellacosa A, ... ... Nussenzweig A, et al. BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance. Cell Reports. 25: 1384. PMID 30380426 DOI: 10.1016/J.Celrep.2018.10.009 |
0.326 |
|
| 2018 |
Sasanuma H, Tsuda M, Morimoto S, Saha LK, Rahman MM, Kiyooka Y, Fujiike H, Cherniack AD, Itou J, Callen Moreu E, Toi M, Nakada S, Tanaka H, Tsutsui K, Yamada S, ... Nussenzweig A, et al. BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes. Proceedings of the National Academy of Sciences of the United States of America. PMID 30352856 DOI: 10.1073/Pnas.1803177115 |
0.475 |
|
| 2018 |
Das P, Veazey KJ, Van HT, Kaushik S, Lin K, Lu Y, Ishii M, Kikuta J, Ge K, Nussenzweig A, Santos MA. Histone methylation regulator PTIP is required to maintain normal and leukemic bone marrow niches. Proceedings of the National Academy of Sciences of the United States of America. PMID 30297393 DOI: 10.1073/Pnas.1806019115 |
0.32 |
|
| 2018 |
Chu SH, Song EJ, Chabon JR, Minehart J, Matovina CN, Makofske JL, Frank ES, Ross K, Koche RP, Feng Z, Xu H, Krivtsov A, Nussenzweig A, Armstrong SA. Inhibition of MEK and ATR is effective in a B-cell acute lymphoblastic leukemia model driven by and activated . Blood Advances. 2: 2478-2490. PMID 30266823 DOI: 10.1182/Bloodadvances.2018021592 |
0.334 |
|
| 2018 |
Nacson J, Krais JJ, Bernhardy AJ, Clausen E, Feng W, Wang Y, Nicolas E, Cai KQ, Tricarico R, Hua X, DiMarcantonio D, Martinez E, Zong D, Handorf EA, Bellacosa A, ... ... Nussenzweig A, et al. BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance. Cell Reports. 24: 3513-3527.e7. PMID 30257212 DOI: 10.1016/J.Celrep.2018.08.086 |
0.461 |
|
| 2018 |
van Wietmarschen N, Nussenzweig A. Mechanism for Synthetic Lethality in BRCA-Deficient Cancers: No Longer Lagging Behind. Molecular Cell. 71: 877-878. PMID 30241603 DOI: 10.1016/J.Molcel.2018.08.045 |
0.427 |
|
| 2018 |
Tubbs A, Sridharan S, van Wietmarschen N, Maman Y, Callen E, Stanlie A, Wu W, Wu X, Day A, Wong N, Yin M, Canela A, Fu H, Redon C, Pruitt SC, ... ... Nussenzweig A, et al. Dual Roles of Poly(dA:dT) Tracts in Replication Initiation and Fork Collapse. Cell. PMID 30078706 DOI: 10.1016/J.Cell.2018.07.011 |
0.411 |
|
| 2018 |
Vian L, Pękowska A, Rao SSP, Kieffer-Kwon KR, Jung S, Baranello L, Huang SC, El Khattabi L, Dose M, Pruett N, Sanborn AL, Canela A, Maman Y, Oksanen A, Resch W, ... ... Nussenzweig A, et al. The Energetics and Physiological Impact of Cohesin Extrusion. Cell. PMID 29706548 DOI: 10.1016/J.Cell.2018.03.072 |
0.457 |
|
| 2018 |
Weyemi U, Paul BD, Snowman AM, Jailwala P, Nussenzweig A, Bonner WM, Snyder SH. Histone H2AX deficiency causes neurobehavioral deficits and impaired redox homeostasis. Nature Communications. 9: 1526. PMID 29670103 DOI: 10.1038/S41467-018-03948-9 |
0.417 |
|
| 2018 |
Gupta R, Somyajit K, Narita T, Maskey E, Stanlie A, Kremer M, Typas D, Lammers M, Mailand N, Nussenzweig A, Lukas J, Choudhary C. DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity. Cell. PMID 29656893 DOI: 10.1016/J.Cell.2018.03.050 |
0.561 |
|
| 2018 |
Gutierrez-Martinez P, Hogdal L, Nagai M, Kruta M, Singh R, Sarosiek K, Nussenzweig A, Beerman I, Letai A, Rossi DJ. Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage. Nature Cell Biology. PMID 29531308 DOI: 10.1038/S41556-018-0054-Y |
0.5 |
|
| 2018 |
Di Siena S, Campolo F, Gimmelli R, Di Pietro C, Marazziti D, Dolci S, Lenzi A, Nussenzweig A, Pellegrini M. Atm reactivation reverses ataxia telangiectasia phenotypes in vivo. Cell Death & Disease. 9: 314. PMID 29472706 DOI: 10.1038/S41419-018-0357-8 |
0.741 |
|
| 2018 |
Chu SH, Chabon J, Minehart J, Matovina CN, Zhang J, Chen B, Callen-Moreu E, Hung PJ, Feng Z, Koche R, Liu XS, Chaudhuri J, Nussenzweig A, Sleckman B, Armstrong SA. The Lysine Histone Methyltransferase SETD2 Is Required for Appropriate Immunoglobulin VDJ Recombination Blood. 132: 511-511. DOI: 10.1182/Blood-2018-99-111952 |
0.515 |
|
| 2017 |
Mijic S, Zellweger R, Chappidi N, Berti M, Jacobs K, Mutreja K, Ursich S, Ray Chaudhuri A, Nussenzweig A, Janscak P, Lopes M. Replication fork reversal triggers fork degradation in BRCA2-defective cells. Nature Communications. 8: 859. PMID 29038466 DOI: 10.1038/S41467-017-01164-5 |
0.499 |
|
| 2017 |
Ray Chaudhuri A, Nussenzweig A. Thwarting endogenous stress: BRCA protects against aldehyde toxicity. Embo Molecular Medicine. 9: 1331-1333. PMID 28835508 DOI: 10.15252/Emmm.201708194 |
0.517 |
|
| 2017 |
Canela A, Maman Y, Jung S, Wong N, Callen E, Day A, Kieffer-Kwon KR, Pekowska A, Zhang H, Rao SSP, Huang SC, Mckinnon PJ, Aplan PD, Pommier Y, Aiden EL, ... ... Nussenzweig A, et al. Genome Organization Drives Chromosome Fragility. Cell. PMID 28735753 DOI: 10.1016/J.Cell.2017.06.034 |
0.528 |
|
| 2017 |
Ray Chaudhuri A, Nussenzweig A. The multifaceted roles of PARP1 in DNA repair and chromatin remodelling. Nature Reviews. Molecular Cell Biology. 18: 610-621. PMID 28676700 DOI: 10.1038/Nrm.2017.53 |
0.573 |
|
| 2017 |
Yazinski SA, Comaills V, Buisson R, Genois MM, Nguyen HD, Ho CK, Todorova Kwan T, Morris R, Lauffer S, Nussenzweig A, Ramaswamy S, Benes CH, Haber DA, Maheswaran S, Birrer MJ, et al. ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells. Genes & Development. PMID 28242626 DOI: 10.1101/Gad.290957.116 |
0.392 |
|
| 2017 |
Tubbs A, Nussenzweig A. Endogenous DNA Damage as a Source of Genomic Instability in Cancer. Cell. 168: 644-656. PMID 28187286 DOI: 10.1016/J.Cell.2017.01.002 |
0.486 |
|
| 2017 |
Greer YE, Gao B, Yang Y, Nussenzweig A, Rubin JS. Lack of Casein Kinase 1 Delta Promotes Genomic Instability - The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1. Plos One. 12: e0170903. PMID 28125685 DOI: 10.1371/Journal.Pone.0170903 |
0.475 |
|
| 2017 |
Chaudhuri AR, Callen E, Ding X, Gogola E, Duarte AA, Lee J, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S, Day A, Crespo AV, Shen B, Starnes LM, ... ... Nussenzweig A, et al. Abstract IA09: Replication fork stability confers chemoresistance in BRCA-deficient cells Molecular Cancer Research. 15. DOI: 10.1158/1557-3125.Dnarepair16-Ia09 |
0.76 |
|
| 2016 |
Skau CT, Fischer RS, Gurel P, Thiam HR, Tubbs A, Baird MA, Davidson MW, Piel M, Alushin GM, Nussenzweig A, Steeg PS, Waterman CM. FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis. Cell. PMID 27839864 DOI: 10.1016/J.Cell.2016.10.023 |
0.431 |
|
| 2016 |
Chaudhuri AR, Callen E, Ding X, Gogola E, Duarte AA, Lee JE, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S, Day A, Crespo AV, Shen B, Starnes LM, ... ... Nussenzweig A, et al. Erratum: Replication fork stability confers chemoresistance in BRCA-deficient cells. Nature. PMID 27680696 DOI: 10.1038/nature19826 |
0.618 |
|
| 2016 |
Li M, Cole F, Patel DS, Misenko SM, Her J, Malhowski A, Alhamza A, Zheng H, Baer R, Ludwig T, Jasin M, Nussenzweig A, Serrano L, Bunting SF. 53BP1 ablation rescues genomic instability in mice expressing 'RING-less' BRCA1. Embo Reports. PMID 27670884 DOI: 10.15252/Embr.201642497 |
0.512 |
|
| 2016 |
Morgado-Palacin I, Day A, Murga M, Lafarga V, Anton ME, Tubbs A, Chen HT, Ergan A, Anderson R, Bhandoola A, Pike KG, Barlaam B, Cadogan E, Wang X, Pierce AJ, ... ... Nussenzweig A, et al. Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML. Science Signaling. 9: ra91. PMID 27625305 DOI: 10.1126/Scisignal.Aad8243 |
0.746 |
|
| 2016 |
Nieto-Soler M, Morgado-Palacin I, Lafarga V, Lecona E, Murga M, Callen E, Azorin D, Alonso J, Lopez-Contreras AJ, Nussenzweig A, Fernandez-Capetillo O. Efficacy of ATR inhibitors as single agents in Ewing sarcoma. Oncotarget. 7: 58759-58767. PMID 27577084 DOI: 10.18632/Oncotarget.11643 |
0.667 |
|
| 2016 |
Ding X, Chaudhuri AR, Callen E, Pang Y, Biswas K, Klarmann KD, Martin BK, Burkett S, Cleveland L, Stauffer S, Sullivan T, Dewan A, Marks H, Tubbs AT, Wong N, ... ... Nussenzweig A, et al. Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies. Nature Communications. 7: 12425. PMID 27498558 DOI: 10.1038/Ncomms12425 |
0.425 |
|
| 2016 |
Zong D, Chaudhuri AR, Nussenzweig A. More end resection is not merrier. Nature Structural & Molecular Biology. 23: 699-701. PMID 27487392 DOI: 10.1038/Nsmb.3274 |
0.559 |
|
| 2016 |
Canela A, Sridharan S, Sciascia N, Tubbs A, Meltzer P, Sleckman BP, Nussenzweig A. DNA Breaks and End Resection Measured Genome-wide by End Sequencing. Molecular Cell. PMID 27477910 DOI: 10.1016/J.Molcel.2016.06.034 |
0.554 |
|
| 2016 |
Ray Chaudhuri A, Callen E, Ding X, Gogola E, Duarte AA, Lee JE, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S, Day A, Crespo AV, Shen B, Starnes LM, ... ... Nussenzweig A, et al. Replication fork stability confers chemoresistance in BRCA-deficient cells. Nature. 535: 382-7. PMID 27443740 DOI: 10.1038/Nature18325 |
0.763 |
|
| 2016 |
Starnes LM, Su D, Pikkupeura LM, Weinert BT, Santos MA, Mund A, Soria R, Cho YW, Pozdnyakova I, Kubec Højfeldt M, Vala A, Yang W, López-Méndez B, Lee JE, Peng W, ... ... Nussenzweig A, et al. A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex. Genes & Development. PMID 26744420 DOI: 10.1101/Gad.268797.115 |
0.439 |
|
| 2016 |
Salewsky B, Hildebrand G, Rothe S, Parplys AC, Radszewski J, Kieslich M, Wessendorf P, Krenzlin H, Borgmann K, Nussenzweig A, Sperling K, Digweed M. Directed Alternative Splicing in Nijmegen Breakage Syndrome: Proof of Principle Concerning Its Therapeutical Application. Molecular Therapy : the Journal of the American Society of Gene Therapy. 24: 117-24. PMID 26265251 DOI: 10.1038/mt.2015.144 |
0.328 |
|
| 2016 |
Ortega-Molina A, Boss IW, Canela A, Pan H, Jiang Y, Zhao C, Jiang M, Hu D, Lee J, Chen H, Ennishi D, Scott DW, Hother C, Liu S, Cao X, ... ... Nussenzweig A, et al. Abstract IA18: Functional characterization of the tumor suppressor lysine-specific methyltransferase KMT2D in lymphoma Cancer Research. 76. DOI: 10.1158/1538-7445.Chromepi15-Ia18 |
0.353 |
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| 2015 |
Cloutier JM, Mahadevaiah SK, ElInati E, Nussenzweig A, Tóth A, Turner JM. Histone H2AFX Links Meiotic Chromosome Asynapsis to Prophase I Oocyte Loss in Mammals. Plos Genetics. 11: e1005462. PMID 26509888 DOI: 10.1371/Journal.Pgen.1005462 |
0.542 |
|
| 2015 |
Ortega-Molina A, Boss IW, Canela A, Pan H, Jiang Y, Zhao C, Jiang M, Hu D, Agirre X, Niesvizky I, Lee JE, Chen HT, Ennishi D, Scott DW, Mottok A, ... ... Nussenzweig A, et al. The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development. Nature Medicine. PMID 26366710 DOI: 10.1038/Nm.3943 |
0.364 |
|
| 2015 |
Robbiani DF, Deroubaix S, Feldhahn N, Oliveira TY, Callen E, Wang Q, Jankovic M, Silva IT, Rommel PC, Bosque D, Eisenreich T, Nussenzweig A, Nussenzweig MC. Plasmodium Infection Promotes Genomic Instability and AID-Dependent B Cell Lymphoma. Cell. 162: 727-37. PMID 26276629 DOI: 10.1016/J.Cell.2015.07.019 |
0.403 |
|
| 2015 |
Canela A, Stanlie A, Nussenzweig A. Collateral DNA damage produced by genome-editing drones: exception or rule? Molecular Cell. 58: 565-7. PMID 26000841 DOI: 10.1016/J.Molcel.2015.05.012 |
0.42 |
|
| 2015 |
Zong D, Callén E, Pegoraro G, Lukas C, Lukas J, Nussenzweig A. Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining. Nucleic Acids Research. 43: 4950-61. PMID 25916843 DOI: 10.1093/Nar/Gkv336 |
0.566 |
|
| 2015 |
Lopez-Contreras AJ, Specks J, Barlow JH, Ambrogio C, Desler C, Vikingsson S, Rodrigo-Perez S, Green H, Rasmussen LJ, Murga M, Nussenzweig A, Fernandez-Capetillo O. Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice. Genes & Development. 29: 690-5. PMID 25838540 DOI: 10.1101/Gad.256958.114 |
0.658 |
|
| 2015 |
Naranjo-Suarez S, Callen E, Zhong Y, Makohon-Moore A, Nussenzweig A, Iacobuzio-Donahue C. Abstract A68: Hypoxia-induced CHK1 repression may enhance the mutator phenotype of pancreatic cancer cells Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-A68 |
0.455 |
|
| 2015 |
Patel S, Sukumar M, Palmer D, Roychoudhari R, Roy R, Nussenzweig A, Restifo N. Abstract 1347: Genomic stress in antigen experienced T-lymphocytes Cancer Research. 75: 1347-1347. DOI: 10.1158/1538-7445.Am2015-1347 |
0.345 |
|
| 2014 |
Wessendorf P, Vijg J, Nussenzweig A, Digweed M. Deficiency of the DNA repair protein nibrin increases the basal but not the radiation induced mutation frequency in vivo. Mutation Research. 769: 11-6. PMID 25771721 DOI: 10.1016/J.Mrfmmm.2014.07.001 |
0.506 |
|
| 2014 |
Santos MA, John S, Nussenzweig A. Tumor promoting role of the DNA damage response. Cell Cycle (Georgetown, Tex.). 13: 2807-8. PMID 25486465 DOI: 10.4161/15384101.2014.959855 |
0.578 |
|
| 2014 |
Barlow JH, Nussenzweig A. Replication initiation and genome instability: a crossroads for DNA and RNA synthesis. Cellular and Molecular Life Sciences : Cmls. 71: 4545-59. PMID 25238783 DOI: 10.1007/S00018-014-1721-1 |
0.56 |
|
| 2014 |
Santos MA, Faryabi RB, Ergen AV, Day AM, Malhowski A, Canela A, Onozawa M, Lee JE, Callen E, Gutierrez-Martinez P, Chen HT, Wong N, Finkel N, Deshpande A, Sharrow S, ... ... Nussenzweig A, et al. DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier. Nature. 514: 107-11. PMID 25079327 DOI: 10.1038/Nature13483 |
0.783 |
|
| 2014 |
Polato F, Callen E, Wong N, Faryabi R, Bunting S, Chen HT, Kozak M, Kruhlak MJ, Reczek CR, Lee WH, Ludwig T, Baer R, Feigenbaum L, Jackson S, Nussenzweig A. CtIP-mediated resection is essential for viability and can operate independently of BRCA1. The Journal of Experimental Medicine. 211: 1027-36. PMID 24842372 DOI: 10.1084/Jem.20131939 |
0.819 |
|
| 2014 |
Ira G, Nussenzweig A. A new Riff: Rif1 eats its cake and has it too. Embo Reports. 15: 622-4. PMID 24769453 DOI: 10.1002/Embr.201438825 |
0.43 |
|
| 2013 |
Fernandez-Capetillo O, Nussenzweig A. Naked replication forks break apRPArt. Cell. 155: 979-80. PMID 24267882 DOI: 10.1016/J.Cell.2013.10.049 |
0.718 |
|
| 2013 |
Lee BS, Gapud EJ, Zhang S, Dorsett Y, Bredemeyer A, George R, Callen E, Daniel JA, Osipovich O, Oltz EM, Bassing CH, Nussenzweig A, Lees-Miller S, Hammel M, Chen BP, et al. Functional intersection of ATM and DNA-dependent protein kinase catalytic subunit in coding end joining during V(D)J recombination. Molecular and Cellular Biology. 33: 3568-79. PMID 23836881 DOI: 10.1128/Mcb.00308-13 |
0.556 |
|
| 2013 |
Bunting SF, Nussenzweig A. End-joining, translocations and cancer Nature Reviews Cancer. 13: 443-454. PMID 23760025 DOI: 10.1038/Nrc3537 |
0.438 |
|
| 2013 |
Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, Chen HT, Faryabi RB, Polato F, Santos M, Starnes LM, Wesemann DR, Lee JE, Tubbs A, Sleckman BP, Daniel JA, ... ... Nussenzweig A, et al. 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell. 153: 1266-80. PMID 23727112 DOI: 10.1016/J.Cell.2013.05.023 |
0.848 |
|
| 2013 |
Daniel JA, Nussenzweig A. The AID-induced DNA damage response in chromatin Molecular Cell. 50: 309-321. PMID 23664375 DOI: 10.1016/J.Molcel.2013.04.017 |
0.577 |
|
| 2013 |
Bowman-Colin C, Xia B, Bunting S, Klijn C, Drost R, Bouwman P, Fineman L, Chen X, Culhane AC, Cai H, Rodig SJ, Bronson RT, Jonkers J, Nussenzweig A, Kanellopoulou C, et al. Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 110: 8632-7. PMID 23657012 DOI: 10.1073/Pnas.1305362110 |
0.446 |
|
| 2013 |
Barlow JH, Faryabi RB, Callén E, Wong N, Malhowski A, Chen HT, Gutierrez-Cruz G, Sun HW, McKinnon P, Wright G, Casellas R, Robbiani DF, Staudt L, Fernandez-Capetillo O, Nussenzweig A. Identification of early replicating fragile sites that contribute to genome instability. Cell. 152: 620-32. PMID 23352430 DOI: 10.1016/J.Cell.2013.01.006 |
0.846 |
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| 2013 |
Di Virgilio M, Callen E, Yamane A, Zhang W, Jankovic M, Gitlin AD, Feldhahn N, Resch W, Oliveira TY, Chait BT, Nussenzweig A, Casellas R, Robbiani DF, Nussenzweig MC. Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching. Science (New York, N.Y.). 339: 711-5. PMID 23306439 DOI: 10.1126/Science.1230624 |
0.643 |
|
| 2013 |
Yamane A, Robbiani DF, Resch W, Bothmer A, Nakahashi H, Oliveira T, Rommel PC, Brown EJ, Nussenzweig A, Nussenzweig MC, Casellas R. RPA accumulation during class switch recombination represents 5'-3' DNA-end resection during the S-G2/M phase of the cell cycle. Cell Reports. 3: 138-47. PMID 23291097 DOI: 10.1016/J.Celrep.2012.12.006 |
0.5 |
|
| 2013 |
Bothmer A, Rommel PC, Gazumyan A, Polato F, Reczek CR, Muellenbeck MF, Schaetzlein S, Edelmann W, Chen PL, Brosh RM, Casellas R, Ludwig T, Baer R, Nussenzweig A, Nussenzweig MC, et al. Mechanism of DNA resection during intrachromosomal recombination and immunoglobulin class switching. The Journal of Experimental Medicine. 210: 115-23. PMID 23254285 DOI: 10.1084/Jem.20121975 |
0.582 |
|
| 2012 |
Sin HS, Barski A, Zhang F, Kartashov AV, Nussenzweig A, Chen J, Andreassen PR, Namekawa SH. RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in post-meiotic spermatids. Genes & Development. 26: 2737-48. PMID 23249736 DOI: 10.1101/Gad.202713.112 |
0.441 |
|
| 2012 |
Callen E, Faryabi RB, Luckey M, Hao B, Daniel JA, Yang W, Sun HW, Dressler G, Peng W, Chi H, Ge K, Krangel MS, Park JH, Nussenzweig A. The DNA Damage- and Transcription-Associated Protein Paxip1 Controls Thymocyte Development and Emigration Immunity. 37: 971-985. PMID 23159437 DOI: 10.1016/J.Immuni.2012.10.007 |
0.784 |
|
| 2012 |
Muñoz MC, Laulier C, Gunn A, Cheng A, Robbiani DF, Nussenzweig A, Stark JM. RING finger nuclear factor RNF168 is important for defects in homologous recombination caused by loss of the breast cancer susceptibility factor BRCA1. The Journal of Biological Chemistry. 287: 40618-28. PMID 23055523 DOI: 10.1074/Jbc.M112.410951 |
0.494 |
|
| 2012 |
Feldhahn N, Ferretti E, Robbiani DF, Callen E, Deroubaix S, Selleri L, Nussenzweig A, Nussenzweig MC. The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo. The Embo Journal. 31: 4045-56. PMID 22940690 DOI: 10.1038/Emboj.2012.247 |
0.582 |
|
| 2012 |
Daniel JA, Pellegrini M, Lee BS, Guo Z, Filsuf D, Belkina NV, You Z, Paull TT, Sleckman BP, Feigenbaum L, Nussenzweig A. Loss of ATM kinase activity leads to embryonic lethality in mice Journal of Cell Biology. 198: 295-304. PMID 22869595 DOI: 10.1083/Jcb.201204035 |
0.688 |
|
| 2012 |
Daniel JA, Nussenzweig A. Roles for histone H3K4 methyltransferase activities during immunoglobulin class-switch recombination Biochimica Et Biophysica Acta - Gene Regulatory Mechanisms. 1819: 733-738. PMID 22710321 DOI: 10.1016/J.Bbagrm.2012.01.019 |
0.428 |
|
| 2012 |
Bunting SF, Callén E, Kozak ML, Kim JM, Wong N, López-Contreras AJ, Ludwig T, Baer R, Faryabi RB, Malhowski A, Chen HT, Fernandez-Capetillo O, D'Andrea A, Nussenzweig A. BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair. Molecular Cell. 46: 125-35. PMID 22445484 DOI: 10.1016/J.Molcel.2012.02.015 |
0.864 |
|
| 2012 |
Hakim O, Resch W, Yamane A, Klein I, Kieffer-Kwon KR, Jankovic M, Oliveira T, Bothmer A, Voss TC, Ansarah-Sobrinho C, Mathe E, Liang G, Cobell J, Nakahashi H, Robbiani DF, ... Nussenzweig A, et al. DNA damage defines sites of recurrent chromosomal translocations in B lymphocytes. Nature. 484: 69-74. PMID 22314321 DOI: 10.1038/Nature10909 |
0.578 |
|
| 2011 |
Klein IA, Resch W, Jankovic M, Oliveira T, Yamane A, Nakahashi H, Di Virgilio M, Bothmer A, Nussenzweig A, Robbiani DF, Casellas R, Nussenzweig MC. Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes. Cell. 147: 95-106. PMID 21962510 DOI: 10.1016/J.Cell.2011.07.048 |
0.465 |
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| 2011 |
Bothmer A, Robbiani DF, Di Virgilio M, Bunting SF, Klein IA, Feldhahn N, Barlow J, Chen HT, Bosque D, Callen E, Nussenzweig A, Nussenzweig MC. Regulation of DNA End Joining, Resection, and Immunoglobulin Class Switch Recombination by 53BP1 Molecular Cell. 42: 319-329. PMID 21549309 DOI: 10.1016/J.Molcel.2011.03.019 |
0.59 |
|
| 2011 |
Ichijima Y, Ichijima M, Lou Z, Nussenzweig A, Camerini-Otero RD, Chen J, Andreassen PR, Namekawa SH. MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. Genes & Development. 25: 959-71. PMID 21536735 DOI: 10.1101/Gad.2030811 |
0.489 |
|
| 2011 |
Zhang S, Yajima H, Huynh H, Zheng J, Callen E, Chen HT, Wong N, Bunting S, Lin YF, Li M, Lee KJ, Story M, Gapud E, Sleckman BP, Nussenzweig A, et al. Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair. The Journal of Cell Biology. 193: 295-305. PMID 21482716 DOI: 10.1083/Jcb.201009074 |
0.576 |
|
| 2011 |
Fernando RN, Eleuteri B, Abdelhady S, Nussenzweig A, Andäng M, Ernfors P. Cell cycle restriction by histone H2AX limits proliferation of adult neural stem cells. Proceedings of the National Academy of Sciences of the United States of America. 108: 5837-42. PMID 21436033 DOI: 10.1073/Pnas.1014993108 |
0.33 |
|
| 2011 |
Gapud EJ, Dorsett Y, Yin B, Callen E, Bredemeyer A, Mahowald GK, Omi KQ, Walker LM, Bednarski JJ, McKinnon PJ, Bassing CH, Nussenzweig A, Sleckman BP. Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. Proceedings of the National Academy of Sciences of the United States of America. 108: 2022-7. PMID 21245316 DOI: 10.1073/Pnas.1013295108 |
0.58 |
|
| 2011 |
Pellegrini M, Claps G, Orlova VV, Barrios F, Dolci S, Geremia R, Rossi P, Rossi G, Arnold B, Chavakis T, Feigenbaum L, Sharan SK, Nussenzweig A. Targeted JAM-C deletion in germ cells by Spo11-controlled Cre recombinase. Journal of Cell Science. 124: 91-9. PMID 21147852 DOI: 10.1242/Dev.063149 |
0.613 |
|
| 2010 |
Daniel JA, Santos MA, Wang Z, Zang C, Schwab KR, Jankovic M, Filsuf D, Chen HT, Gazumyan A, Yamane A, Cho YW, Sun HW, Ge K, Peng W, Nussenzweig MC, ... ... Nussenzweig A, et al. PTIP promotes chromatin changes critical for immunoglobulin class switch recombination Science. 329: 917-923. PMID 20671152 DOI: 10.1126/Science.1187942 |
0.456 |
|
| 2010 |
Bunting SF, Nussenzweig A. Dangerous liaisons: Fanconi anemia and toxic nonhomologous end joining in DNA crosslink repair. Molecular Cell. 39: 164-6. PMID 20670885 DOI: 10.1016/J.Molcel.2010.07.016 |
0.498 |
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| 2010 |
Santos MA, Huen MS, Jankovic M, Chen HT, López-Contreras AJ, Klein IA, Wong N, Barbancho JL, Fernandez-Capetillo O, Nussenzweig MC, Chen J, Nussenzweig A. Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8. The Journal of Experimental Medicine. 207: 973-81. PMID 20385748 DOI: 10.1084/Jem.20092308 |
0.74 |
|
| 2010 |
Nussenzweig A, Nussenzweig MC. Origin of chromosomal translocations in lymphoid cancer. Cell. 141: 27-38. PMID 20371343 DOI: 10.1016/J.Cell.2010.03.016 |
0.386 |
|
| 2010 |
Bothmer A, Robbiani DF, Feldhahn N, Gazumyan A, Nussenzweig A, Nussenzweig MC. 53BP1 regulates DNA resection and the choice between classical and alternative end joining during class switch recombination. The Journal of Experimental Medicine. 207: 855-65. PMID 20368578 DOI: 10.1084/Jem.20100244 |
0.589 |
|
| 2010 |
Bunting SF, Callén E, Wong N, Chen HT, Polato F, Gunn A, Bothmer A, Feldhahn N, Fernandez-Capetillo O, Cao L, Xu X, Deng CX, Finkel T, Nussenzweig M, Stark JM, ... Nussenzweig A, et al. 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell. 141: 243-54. PMID 20362325 DOI: 10.1016/J.Cell.2010.03.012 |
0.783 |
|
| 2010 |
Boboila C, Yan C, Wesemann DR, Jankovic M, Wang JH, Manis J, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes class switch recombination in the absence of both Ku70 and DNA ligase 4. The Journal of Experimental Medicine. 207: 417-27. PMID 20142431 DOI: 10.1084/Jem.20092449 |
0.499 |
|
| 2010 |
Boboila C, Jankovic M, Yan CT, Wang JH, Wesemann DR, Zhang T, Fazeli A, Feldman L, Nussenzweig A, Nussenzweig M, Alt FW. Alternative end-joining catalyzes robust IgH locus deletions and translocations in the combined absence of ligase 4 and Ku70. Proceedings of the National Academy of Sciences of the United States of America. 107: 3034-9. PMID 20133803 DOI: 10.1073/Pnas.0915067107 |
0.474 |
|
| 2010 |
Jankovic M, Robbiani DF, Dorsett Y, Eisenreich T, Xu Y, Tarakhovsky A, Nussenzweig A, Nussenzweig MC. Role of the translocation partner in protection against AID-dependent chromosomal translocations. Proceedings of the National Academy of Sciences of the United States of America. 107: 187-92. PMID 19966290 DOI: 10.1073/Pnas.0908946107 |
0.45 |
|
| 2010 |
Bunting SF, Nussenzweig A. Dangerous liaisons: Fanconi anemia and toxic nonhomologous end joining in DNA crosslink repair Molecular Cell. 39: 164-166. DOI: 10.1016/j.molcel.2010.07.016 |
0.399 |
|
| 2009 |
Robbiani DF, Bunting S, Feldhahn N, Bothmer A, Camps J, Deroubaix S, McBride KM, Klein IA, Stone G, Eisenreich TR, Ried T, Nussenzweig A, Nussenzweig MC. AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Molecular Cell. 36: 631-41. PMID 19941823 DOI: 10.1016/J.Molcel.2009.11.007 |
0.489 |
|
| 2009 |
Kawauchi S, Calof AL, Santos R, Lopez-Burks ME, Young CM, Hoang MP, Chua A, Lao T, Lechner MS, Daniel JA, Nussenzweig A, Kitzes L, Yokomori K, Hallgrimsson B, Lander AD. Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange Syndrome. Plos Genetics. 5: e1000650. PMID 19763162 DOI: 10.1371/Journal.Pgen.1000650 |
0.419 |
|
| 2009 |
Cao L, Xu X, Bunting SF, Liu J, Wang RH, Cao LL, Wu JJ, Peng TN, Chen J, Nussenzweig A, Deng CX, Finkel T. A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Molecular Cell. 35: 534-41. PMID 19716796 DOI: 10.1016/J.Molcel.2009.06.037 |
0.461 |
|
| 2009 |
Murga M, Bunting S, Montaña MF, Soria R, Mulero F, Cañamero M, Lee Y, McKinnon PJ, Nussenzweig A, Fernandez-Capetillo O. A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nature Genetics. 41: 891-8. PMID 19620979 DOI: 10.1038/Ng.420 |
0.675 |
|
| 2009 |
Wang JH, Gostissa M, Yan CT, Goff P, Hickernell T, Hansen E, Difilippantonio S, Wesemann DR, Zarrin AA, Rajewsky K, Nussenzweig A, Alt FW. Mechanisms promoting translocations in editing and switching peripheral B cells. Nature. 460: 231-6. PMID 19587764 DOI: 10.1038/Nature08159 |
0.733 |
|
| 2009 |
Callén E, Bunting S, Huang CY, Difilippantonio MJ, Wong N, Khor B, Mahowald G, Kruhlak MJ, Ried T, Sleckman BP, Nussenzweig A. Chimeric IgH-TCRalpha/delta translocations in T lymphocytes mediated by RAG. Cell Cycle (Georgetown, Tex.). 8: 2408-12. PMID 19556863 DOI: 10.4161/Cc.8.15.9085 |
0.744 |
|
| 2009 |
Callén E, Jankovic M, Wong N, Zha S, Chen HT, Difilippantonio S, Di Virgilio M, Heidkamp G, Alt FW, Nussenzweig A, Nussenzweig M. Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes. Molecular Cell. 34: 285-97. PMID 19450527 DOI: 10.1016/J.Molcel.2009.04.025 |
0.819 |
|
| 2009 |
Kruhlak MJ, Celeste A, Nussenzweig A. Monitoring DNA breaks in optically highlighted chromatin in living cells by laser scanning confocal microscopy. Methods in Molecular Biology (Clifton, N.J.). 523: 125-40. PMID 19381917 DOI: 10.1007/978-1-59745-190-1_9 |
0.527 |
|
| 2009 |
Economopoulou M, Langer HF, Celeste A, Orlova VV, Choi EY, Ma M, Vassilopoulos A, Callen E, Deng C, Bassing CH, Boehm M, Nussenzweig A, Chavakis T. Histone H2AX is integral to hypoxia-driven neovascularization. Nature Medicine. 15: 553-8. PMID 19377486 DOI: 10.1038/Nm.1947 |
0.5 |
|
| 2009 |
Kim YC, Gerlitz G, Furusawa T, Catez F, Nussenzweig A, Oh KS, Kraemer KH, Shiloh Y, Bustin M. Activation of ATM depends on chromatin interactions occurring before induction of DNA damage. Nature Cell Biology. 11: 92-6. PMID 19079244 DOI: 10.1038/Ncb1817 |
0.553 |
|
| 2009 |
Nussenzweig A. Chromatin Responses to DNA damage Biophysical Journal. 96: 543a. DOI: 10.1016/j.bpj.2008.12.2941 |
0.461 |
|
| 2008 |
Robbiani DF, Bothmer A, Callen E, Reina-San-Martin B, Dorsett Y, Difilippantonio S, Bolland DJ, Chen HT, Corcoran AE, Nussenzweig A, Nussenzweig MC. AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations. Cell. 135: 1028-38. PMID 19070574 DOI: 10.1016/J.Cell.2008.09.062 |
0.787 |
|
| 2008 |
Daniel JA, Pellegrini M, Lee JH, Paull TT, Feigenbaum L, Nussenzweig A. Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo Journal of Cell Biology. 183: 777-783. PMID 19047460 DOI: 10.1083/Jcb.200805154 |
0.753 |
|
| 2008 |
Difilippantonio S, Gapud E, Wong N, Huang CY, Mahowald G, Chen HT, Kruhlak MJ, Callen E, Livak F, Nussenzweig MC, Sleckman BP, Nussenzweig A. 53BP1 facilitates long-range DNA end-joining during V(D)J recombination. Nature. 456: 529-33. PMID 18931658 DOI: 10.1038/Nature07476 |
0.798 |
|
| 2008 |
Fernandez-Capetillo O, Nussenzweig A. ATM breaks into heterochromatin. Molecular Cell. 31: 303-4. PMID 18691960 DOI: 10.1016/J.Molcel.2008.07.004 |
0.743 |
|
| 2008 |
Takizawa M, Tolarová H, Li Z, Dubois W, Lim S, Callen E, Franco S, Mosaico M, Feigenbaum L, Alt FW, Nussenzweig A, Potter M, Casellas R. AID expression levels determine the extent of cMyc oncogenic translocations and the incidence of B cell tumor development. The Journal of Experimental Medicine. 205: 1949-57. PMID 18678733 DOI: 10.1084/Jem.20081007 |
0.46 |
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| 2008 |
Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, Callén E, Celeste A, Pagani M, Opravil S, De La Rosa-Velazquez IA, Espejo A, Bedford MT, Nussenzweig A, Busslinger M, Jenuwein T. A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes & Development. 22: 2048-61. PMID 18676810 DOI: 10.1101/Gad.476008 |
0.483 |
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| 2008 |
Callén E, Nussenzweig MC, Nussenzweig A. Breaking down cell cycle checkpoints and DNA repair during antigen receptor gene assembly. Oncogene. 26: 7759-64. PMID 18066088 DOI: 10.1038/Sj.Onc.1210873 |
0.596 |
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| 2007 |
Nussenzweig A, Nussenzweig MC. A backup DNA repair pathway moves to the forefront. Cell. 131: 223-5. PMID 17956720 DOI: 10.1016/J.Cell.2007.10.005 |
0.443 |
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| 2007 |
Nussenzweig A. Causes and consequences of the DNA damage response. Cell Cycle (Georgetown, Tex.). 6: 2339-40. PMID 17914283 DOI: 10.4161/Cc.6.19.4995 |
0.61 |
|
| 2007 |
Difilippantonio S, Nussenzweig A. The NBS1-ATM connection revisited. Cell Cycle (Georgetown, Tex.). 6: 2366-70. PMID 17881893 DOI: 10.4161/Cc.6.19.4758 |
0.764 |
|
| 2007 |
Curry JD, Schulz D, Guidos CJ, Danska JS, Nutter L, Nussenzweig A, Schlissel MS. Chromosomal reinsertion of broken RSS ends during T cell development. The Journal of Experimental Medicine. 204: 2293-303. PMID 17785508 DOI: 10.1084/Jem.20070583 |
0.474 |
|
| 2007 |
Jankovic M, Nussenzweig A, Nussenzweig MC. Antigen receptor diversification and chromosome translocations. Nature Immunology. 8: 801-8. PMID 17641661 DOI: 10.1038/Ni1498 |
0.61 |
|
| 2007 |
Kim JA, Kruhlak M, Dotiwala F, Nussenzweig A, Haber JE. Heterochromatin is refractory to γ-H2AX modification in yeast and mammals Journal of Cell Biology. 178: 209-218. PMID 17635934 DOI: 10.1083/Jcb.200612031 |
0.574 |
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| 2007 |
Callén E, Jankovic M, Difilippantonio S, Daniel JA, Chen HT, Celeste A, Pellegrini M, McBride K, Wangsa D, Bredemeyer AL, Sleckman BP, Ried T, Nussenzweig M, Nussenzweig A. ATM Prevents the Persistence and Propagation of Chromosome Breaks in Lymphocytes Cell. 130: 63-75. PMID 17599403 DOI: 10.1016/J.Cell.2007.06.016 |
0.84 |
|
| 2007 |
Downs JA, Nussenzweig MC, Nussenzweig A. Chromatin dynamics and the preservation of genetic information. Nature. 447: 951-8. PMID 17581578 DOI: 10.1038/Nature05980 |
0.575 |
|
| 2007 |
Ramiro A, Reina San-Martin B, McBride K, Jankovic M, Barreto V, Nussenzweig A, Nussenzweig MC. The role of activation-induced deaminase in antibody diversification and chromosome translocations. Advances in Immunology. 94: 75-107. PMID 17560272 DOI: 10.1016/S0065-2776(06)94003-6 |
0.368 |
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| 2007 |
Kruhlak M, Crouch EE, Orlov M, Montaño C, Gorski SA, Nussenzweig A, Misteli T, Phair RD, Casellas R. The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks. Nature. 447: 730-4. PMID 17554310 DOI: 10.1038/Nature05842 |
0.572 |
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| 2007 |
Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature. 447: 725-9. PMID 17554309 DOI: 10.1038/Nature05862 |
0.421 |
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| 2007 |
Soutoglou E, Dorn JF, Sengupta K, Jasin M, Nussenzweig A, Ried T, Danuser G, Misteli T. Positional stability of single double-strand breaks in mammalian cells. Nature Cell Biology. 9: 675-82. PMID 17486118 DOI: 10.1038/Ncb1591 |
0.53 |
|
| 2007 |
Difilippantonio S, Celeste A, Kruhlak MJ, Lee Y, Difilippantonio MJ, Feigenbaum L, Jackson SP, McKinnon PJ, Nussenzweig A. Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis. The Journal of Experimental Medicine. 204: 1003-11. PMID 17485521 DOI: 10.1084/Jem.20070319 |
0.845 |
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| 2007 |
Kuznetsov S, Pellegrini M, Shuda K, Fernandez-Capetillo O, Liu Y, Martin BK, Burkett S, Southon E, Pati D, Tessarollo L, West SC, Donovan PJ, Nussenzweig A, Sharan SK. RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females. The Journal of Cell Biology. 176: 581-92. PMID 17312021 DOI: 10.1083/Jcb.200608130 |
0.77 |
|
| 2007 |
Reina-San-Martin B, Chen J, Nussenzweig A, Nussenzweig MC. Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1-/- B cells. European Journal of Immunology. 37: 235-9. PMID 17183606 DOI: 10.1002/Eji.200636789 |
0.469 |
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| 2006 |
Kruhlak MJ, Celeste A, Nussenzweig A. Spatio-temporal dynamics of chromatin containing DNA breaks. Cell Cycle (Georgetown, Tex.). 5: 1910-2. PMID 16929171 DOI: 10.4161/Cc.5.17.3169 |
0.601 |
|
| 2006 |
Ramiro AR, Nussenzweig MC, Nussenzweig A. Switching on chromosomal translocations. Cancer Research. 66: 7837-9. PMID 16912154 DOI: 10.1158/0008-5472.Can-06-0863 |
0.457 |
|
| 2006 |
Pellegrini M, Celeste A, Difilippantonio S, Guo R, Wang W, Feigenbaum L, Nussenzweig A. Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo. Nature. 443: 222-5. PMID 16906133 DOI: 10.1038/Nature05112 |
0.813 |
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| 2006 |
Kruhlak MJ, Celeste A, Dellaire G, Fernandez-Capetillo O, Müller WG, McNally JG, Bazett-Jones DP, Nussenzweig A. Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks. The Journal of Cell Biology. 172: 823-34. PMID 16520385 DOI: 10.1083/Jcb.200510015 |
0.758 |
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| 2006 |
Nussenzweig A, Paull T. DNA repair: tails of histones lost. Nature. 439: 406-7. PMID 16437102 DOI: 10.1038/439406A |
0.603 |
|
| 2006 |
Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Nussenzweig A, Paull TT, Alt FW, Chen J. MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Molecular Cell. 21: 187-200. PMID 16427009 DOI: 10.1016/J.Molcel.2005.11.025 |
0.622 |
|
| 2006 |
Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature. 440: 105-9. PMID 16400328 DOI: 10.1038/Nature04495 |
0.806 |
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| 2005 |
Ward IM, Difilippantonio S, Minn K, Mueller MD, Molina JR, Yu X, Frisk CS, Ried T, Nussenzweig A, Chen J. 53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice Molecular and Cellular Biology. 25: 10079-10086. PMID 16260621 DOI: 10.1128/Mcb.25.22.10079-10086.2005 |
0.743 |
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| 2005 |
Lan L, Nakajima S, Komatsu K, Nussenzweig A, Shimamoto A, Oshima J, Yasui A. Accumulation of Werner protein at DNA double-strand breaks in human cells. Journal of Cell Science. 118: 4153-62. PMID 16141234 DOI: 10.1242/Jcs.02544 |
0.603 |
|
| 2005 |
Dmitrieva NI, Celeste A, Nussenzweig A, Burg MB. Ku86 preserves chromatin integrity in cells adapted to high NaCl. Proceedings of the National Academy of Sciences of the United States of America. 102: 10730-5. PMID 16027367 DOI: 10.1073/Pnas.0504870102 |
0.6 |
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| 2005 |
Difilippantonio S, Celeste A, Fernandez-Capetillo O, Chen HT, Reina San Martin B, Van Laethem F, Yang YP, Petukhova GV, Eckhaus M, Feigenbaum L, Manova K, Kruhlak M, Camerini-Otero RD, Sharan S, Nussenzweig M, ... Nussenzweig A, et al. Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Nature Cell Biology. 7: 675-85. PMID 15965469 DOI: 10.1038/Ncb1270 |
0.834 |
|
| 2005 |
Reina-San-Martin B, Nussenzweig MC, Nussenzweig A, Difilippantonio S. Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1. Proceedings of the National Academy of Sciences of the United States of America. 102: 1590-5. PMID 15668392 DOI: 10.1073/Pnas.0406289102 |
0.8 |
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| 2005 |
Lee AC, Fernandez-Capetillo O, Pisupati V, Jackson SP, Nussenzweig A. Specific association of mouse MDC1/NFBD1 with NBS1 at sites of DNA-damage. Cell Cycle (Georgetown, Tex.). 4: 177-82. PMID 15611643 DOI: 10.4161/Cc.4.1.1354 |
0.849 |
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| 2005 |
Turner JM, Mahadevaiah SK, Fernandez-Capetillo O, Nussenzweig A, Xu X, Deng CX, Burgoyne PS. Silencing of unsynapsed meiotic chromosomes in the mouse. Nature Genetics. 37: 41-7. PMID 15580272 DOI: 10.1038/Ng1484 |
0.721 |
|
| 2004 |
Reina-San-Martin B, Chen HT, Nussenzweig A, Nussenzweig MC. ATM is required for efficient recombination between immunoglobulin switch regions. The Journal of Experimental Medicine. 200: 1103-10. PMID 15520243 DOI: 10.1084/Jem.20041162 |
0.524 |
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| 2004 |
Coppola V, Barrick CA, Southon EA, Celeste A, Wang K, Chen B, Haddad el-B, Yin J, Nussenzweig A, Subramaniam A, Tessarollo L. Ablation of TrkA function in the immune system causes B cell abnormalities. Development (Cambridge, England). 131: 5185-95. PMID 15459109 DOI: 10.1242/Dev.01383 |
0.343 |
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| 2004 |
Sengupta S, Robles AI, Linke SP, Sinogeeva NI, Zhang R, Pedeux R, Ward IM, Celeste A, Nussenzweig A, Chen J, Halazonetis TD, Harris CC. Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. The Journal of Cell Biology. 166: 801-13. PMID 15364958 DOI: 10.1083/Jcb.200405128 |
0.54 |
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| 2004 |
Ramiro AR, Jankovic M, Eisenreich T, Difilippantonio S, Chen-Kiang S, Muramatsu M, Honjo T, Nussenzweig A, Nussenzweig MC. AID is required for c-myc/IgH chromosome translocations in vivo. Cell. 118: 431-8. PMID 15315756 DOI: 10.1016/J.Cell.2004.08.006 |
0.706 |
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| 2004 |
Daniel R, Ramcharan J, Rogakou E, Taganov KD, Greger JG, Bonner W, Nussenzweig A, Katz RA, Skalka AM. Histone H2AX is phosphorylated at sites of retroviral DNA integration but is dispensable for postintegration repair. The Journal of Biological Chemistry. 279: 45810-4. PMID 15308627 DOI: 10.1074/Jbc.M407886200 |
0.609 |
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| 2004 |
Fernandez-Capetillo O, Lee A, Nussenzweig M, Nussenzweig A. H2AX: the histone guardian of the genome. Dna Repair. 3: 959-67. PMID 15279782 DOI: 10.1016/J.Dnarep.2004.03.024 |
0.845 |
|
| 2004 |
Fernandez-Capetillo O, Nussenzweig A. Aging counts on chromosomes. Nature Genetics. 36: 672-4. PMID 15226747 DOI: 10.1038/Ng0704-672 |
0.623 |
|
| 2004 |
Fernandez-Capetillo O, Allis CD, Nussenzweig A. Phosphorylation of histone H2B at DNA double-strand breaks Journal of Experimental Medicine. 199: 1671-1677. PMID 15197225 DOI: 10.1084/Jem.20032247 |
0.742 |
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| 2004 |
Couëdel C, Mills KD, Barchi M, Shen L, Olshen A, Johnson RD, Nussenzweig A, Essers J, Kanaar R, Li GC, Alt FW, Jasin M. Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells. Genes & Development. 18: 1293-304. PMID 15175261 DOI: 10.1101/Gad.1209204 |
0.576 |
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| 2004 |
Ward IM, Reina-San-Martin B, Olaru A, Minn K, Tamada K, Lau JS, Cascalho M, Chen L, Nussenzweig A, Livak F, Nussenzweig MC, Chen J. 53BP1 is required for class switch recombination. The Journal of Cell Biology. 165: 459-64. PMID 15159415 DOI: 10.1083/Jcb.200403021 |
0.586 |
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| 2004 |
Fernandez-Capetillo O, Nussenzweig A. Linking histone deacetylation with the repair of DNA breaks. Proceedings of the National Academy of Sciences of the United States of America. 101: 1427-8. PMID 14757822 DOI: 10.1073/Pnas.0307342101 |
0.771 |
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| 2004 |
Pilch DR, Sedelnikova OA, Redon C, Celeste A, Nussenzweig A, Bonner WM. Characteristics of gamma-H2AX foci at DNA double-strand breaks sites. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 81: 123-9. PMID 12897845 DOI: 10.1139/O03-042 |
0.541 |
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| 2003 |
Fernandez-Capetillo O, Liebe B, Scherthan H, Nussenzweig A. H2AX regulates meiotic telomere clustering. The Journal of Cell Biology. 163: 15-20. PMID 14530383 DOI: 10.1083/Jcb.200305124 |
0.718 |
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| 2003 |
Fernandez-Capetillo O, Celeste A, Nussenzweig A. Focusing on foci: H2AX and the recruitment of DNA-damage response factors. Cell Cycle (Georgetown, Tex.). 2: 426-7. PMID 12963833 DOI: 10.4161/Cc.2.5.509 |
0.719 |
|
| 2003 |
Rockwood LD, Nussenzweig A, Janz S. Paradoxical decrease in mutant frequencies and chromosomal rearrangements in a transgenic lacZ reporter gene in Ku80 null mice deficient in DNA double strand break repair Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 529: 51-58. PMID 12943919 DOI: 10.1016/S0027-5107(03)00108-8 |
0.467 |
|
| 2003 |
Celeste A, Difilippantonio S, Difilippantonio MJ, Fernandez-Capetillo O, Pilch DR, Sedelnikova OA, Eckhaus M, Ried T, Bonner WM, Nussenzweig A. H2AX haploinsufficiency modifies genomic stability and tumor susceptibility Cell. 114: 371-383. PMID 12914701 DOI: 10.1016/S0092-8674(03)00567-1 |
0.821 |
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| 2003 |
Reina-San-Martin B, Difilippantonio S, Hanitsch L, Masilamani RF, Nussenzweig A, Nussenzweig MC. H2AX is required for recombination between immunoglobulin switch regions but not for intra-switch region recombination or somatic hypermutation. The Journal of Experimental Medicine. 197: 1767-78. PMID 12810694 DOI: 10.1084/Jem.20030569 |
0.752 |
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| 2003 |
Celeste A, Fernandez-Capetillo O, Kruhlak MJ, Pilch DR, Staudt DW, Lee A, Bonner RF, Bonner WM, Nussenzweig A. Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nature Cell Biology. 5: 675-9. PMID 12792649 DOI: 10.1038/Ncb1004 |
0.858 |
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| 2003 |
Fernandez-Capetillo O, Mahadevaiah SK, Celeste A, Romanienko PJ, Camerini-Otero RD, Bonner WM, Manova K, Burgoyne P, Nussenzweig A. H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis. Developmental Cell. 4: 497-508. PMID 12689589 DOI: 10.1016/S1534-5807(03)00093-5 |
0.658 |
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| 2003 |
Furuta T, Takemura H, Liao ZY, Aune GJ, Redon C, Sedelnikova OA, Pilch DR, Rogakou EP, Celeste A, Chen HT, Nussenzweig A, Aladjem MI, Bonner WM, Pommier Y. Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. The Journal of Biological Chemistry. 278: 20303-12. PMID 12660252 DOI: 10.1074/Jbc.M300198200 |
0.608 |
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| 2002 |
Fernandez-Capetillo O, Chen HT, Celeste A, Ward I, Romanienko PJ, Morales JC, Naka K, Xia Z, Camerini-Otero RD, Motoyama N, Carpenter PB, Bonner WM, Chen J, Nussenzweig A. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nature Cell Biology. 4: 993-7. PMID 12447390 DOI: 10.1038/Ncb884 |
0.757 |
|
| 2002 |
Difilippantonio MJ, Petersen S, Chen HT, Johnson R, Jasin M, Kanaar R, Ried T, Nussenzweig A. Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification Journal of Experimental Medicine. 196: 469-480. PMID 12186839 DOI: 10.1084/Jem.20020851 |
0.793 |
|
| 2002 |
Ishii KJ, Takeshita F, Gursel I, Gursel M, Conover J, Nussenzweig A, Klinman DM. Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation. The Journal of Experimental Medicine. 196: 269-74. PMID 12119352 DOI: 10.1084/Jem.20020773 |
0.562 |
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| 2002 |
Celeste A, Petersen S, Romanienko PJ, Fernandez-Capetillo O, Chen HT, Sedelnikova OA, Reina-San-Martin B, Coppola V, Meffre E, Difilippantonio MJ, Redon C, Pilch DR, Olaru A, Eckhaus M, Camerini-Otero RD, ... ... Nussenzweig A, et al. Genomic instability in mice lacking histone H2AX. Science (New York, N.Y.). 296: 922-7. PMID 11934988 DOI: 10.1126/Science.1069398 |
0.847 |
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| 2001 |
Petersen S, Casellas R, Reina-San-Martin B, Chen HT, Difilippantonio MJ, Wilson PC, Hanitsch L, Celeste A, Muramatsu M, Pilch DR, Redon C, Ried T, Bonner WM, Honjo T, Nussenzweig MC, ... Nussenzweig A, et al. AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching Nature. 414: 660-665. PMID 11740565 DOI: 10.1038/414660A |
0.75 |
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| 2001 |
Davodeau F, Difilippantonio M, Roldan E, Malissen M, Casanova JL, Couedel C, Morcet JF, Merkenschlager M, Nussenzweig A, Bonneville M, Malissen B. The tight interallelic positional coincidence that distinguishes T-cell receptor Jalpha usage does not result from homologous chromosomal pairing during ValphaJalpha rearrangement. The Embo Journal. 20: 4717-29. PMID 11532936 DOI: 10.1093/Emboj/20.17.4717 |
0.659 |
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| 2001 |
Sekiguchi J, Ferguson DO, Chen HT, Yang EM, Earle J, Frank K, Whitlow S, Gu Y, Xu Y, Nussenzweig A, Alt FW. Genetic interactions between ATM and the nonhomologous end-joining factors in genomic stability and development. Proceedings of the National Academy of Sciences of the United States of America. 98: 3243-8. PMID 11248063 DOI: 10.1073/Pnas.051632098 |
0.59 |
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| 2001 |
Zhu J, Petersen S, Tessarollo L, Nussenzweig A. Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice. Current Biology : Cb. 11: 105-9. PMID 11231126 DOI: 10.1016/S0960-9822(01)00019-7 |
0.425 |
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| 2000 |
Arrington ED, Caldwell MC, Kumaravel TS, Lohani A, Joshi A, Evans MK, Chen HT, Nussenzweig A, Holbrook NJ, Gorospe M. Enhanced sensitivity and long-term G2 arrest in hydrogen peroxide-treated Ku80-null cells are unrelated to DNA repair defects. Free Radical Biology & Medicine. 29: 1166-76. PMID 11121725 DOI: 10.1016/S0891-5849(00)00439-1 |
0.528 |
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| 2000 |
Chen HT, Bhandoola A, Difilippantonio MJ, Zhu J, Brown MJ, Tai X, Rogakou EP, Brotz TM, Bonner WM, Ried T, Nussenzweig A. Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX. Science (New York, N.Y.). 290: 1962-5. PMID 11110662 DOI: 10.1126/Science.290.5498.1962 |
0.746 |
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| 2000 |
Bhandoola A, Dolnick B, Fayad N, Nussenzweig A, Singer A. Immature thymocytes undergoing receptor rearrangements are resistant to an Atm-dependent death pathway activated in mature T cells by double-stranded DNA breaks. The Journal of Experimental Medicine. 192: 891-7. PMID 10993919 DOI: 10.1084/Jem.192.6.891 |
0.49 |
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| 2000 |
Difilippantonio MJ, Zhu J, Chen HT, Meffre E, Nussenzweig MC, Max EE, Ried T, Nussenzweig A. DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation. Nature. 404: 510-4. PMID 10761921 DOI: 10.1038/35006670 |
0.77 |
|
| 1999 |
Hurd YL, Yakovleva T, Nussenzweig A, Li GC, Terenius L, Bakalkin G. A novel neuron-specific DNA end-binding factor in the murine brain. Molecular and Cellular Neurosciences. 14: 213-24. PMID 10576891 DOI: 10.1006/Mcne.1999.0782 |
0.475 |
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| 1999 |
Qin XF, Schwers S, Yu W, Papavasiliou F, Suh H, Nussenzweig A, Rajewsky K, Nussenzweig MC. Secondary V(D)J recombination in B-1 cells. Nature. 397: 355-9. PMID 9950428 DOI: 10.1038/16933 |
0.314 |
|
| 1998 |
Bakalkin G, Yakovleva T, Hurd YL, Nussenzweig A, Li GC, Terenius L. Autoantigen Ku in the brain. Developmentally regulated expression and subcellular localization. Neuroreport. 9: 2147-51. PMID 9674610 DOI: 10.1097/00001756-199806220-00044 |
0.335 |
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| 1998 |
Casellas R, Nussenzweig A, Wuerffel R, Pelanda R, Reichlin A, Suh H, Qin XF, Besmer E, Kenter A, Rajewsky K, Nussenzweig MC. Ku80 is required for immunoglobulin isotype switching Embo Journal. 17: 2404-2411. PMID 9545251 DOI: 10.1093/Emboj/17.8.2404 |
0.411 |
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| 1998 |
Nussenzweig A, Sokol K, Burgman P, Li L, Li GC. Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development. Proceedings of the National Academy of Sciences of the United States of America. 94: 13588-93. PMID 9391070 DOI: 10.1073/Pnas.94.25.13588 |
0.536 |
|
| 1997 |
Ludwig DL, Chen F, Peterson SR, Nussenzweig A, Li GC, Chen DJ. Ku80 gene expression is Sp1-dependent and sensitive to CpG methylation within a novel cis element. Gene. 199: 181-94. PMID 9358055 DOI: 10.1016/S0378-1119(97)00366-1 |
0.406 |
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| 1997 |
Ouyang H, Nussenzweig A, Kurimasa A, Soares VC, Li X, Cordon-Cardo C, Li Wh, Cheong N, Nussenzweig M, Iliakis G, Chen DJ, Li GC. Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination In vivo. The Journal of Experimental Medicine. 186: 921-9. PMID 9294146 DOI: 10.1084/Jem.186.6.921 |
0.571 |
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| 1996 |
Cortes P, Weis-Garcia F, Misulovin Z, Nussenzweig A, Lai JS, Li G, Nussenzweig MC, Baltimore D. In vitro V(D)J recombination: Signal joint formation Proceedings of the National Academy of Sciences of the United States of America. 93: 14008-14013. PMID 8943051 DOI: 10.1073/Pnas.93.24.14008 |
0.325 |
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| 1996 |
Nussenzweig A, Chen C, da Costa Soares V, Sanchez M, Sokol K, Nussenzweig MC, Li GC. Requirement for Ku80 in growth and immunoglobulin V(D)J recombination. Nature. 382: 551-5. PMID 8700231 DOI: 10.1038/382551A0 |
0.591 |
|
| 1996 |
Yang SH, Nussenzweig A, Li L, Kim D, Ouyang H, Burgman P, Li GC. Modulation of thermal induction of hsp70 expression by Ku autoantigen or its individual subunits. Molecular and Cellular Biology. 16: 3799-806. PMID 8668197 DOI: 10.1128/Mcb.16.7.3799 |
0.304 |
|
| 1996 |
Yang S, Nussenzweig A, Yang W, Kim D, Li GC. Cloning and Characterization of Rat Ku70: Involvement of Ku Autoantigen in the Heat-Shock Response Radiation Research. 146: 603. DOI: 10.2307/3579375 |
0.342 |
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| 1995 |
Kim D, Ouyang H, Yang SH, Nussenzweig A, Burgman P, Li GC. A constitutive heat shock element-binding factor is immunologically identical to the Ku autoantigen. The Journal of Biological Chemistry. 270: 15277-84. PMID 7797514 DOI: 10.1074/Jbc.270.25.15277 |
0.351 |
|
| 1995 |
Li GC, Yang SH, Kim D, Nussenzweig A, Ouyang H, Wei J, Burgman P, Li L. Suppression of heat-induced hsp70 expression by the 70-kDa subunit of the human Ku autoantigen. Proceedings of the National Academy of Sciences of the United States of America. 92: 4512-6. PMID 7753835 DOI: 10.1073/Pnas.92.10.4512 |
0.303 |
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