| Year |
Citation |
Score |
| 2024 |
Colmant L, Boyer E, Gerard T, Sleegers K, Lhommel R, Ivanoiu A, Lefèvre P, Kienlen-Campard P, Hanseeuw B. Definition of a Threshold for the Plasma Aβ42/Aβ40 Ratio Measured by Single-Molecule Array to Predict the Amyloid Status of Individuals without Dementia. International Journal of Molecular Sciences. 25. PMID 38256246 DOI: 10.3390/ijms25021173 |
0.386 |
|
| 2023 |
Le Borgne J, Amouyel P, Andreassen O, Frikke-Schmidt R, Hiltunen M, Ingelsson M, Ramirez A, Rossi G, Ruiz A, Sanchez-Juan P, Sims R, Sleegers K, Tsolaki M, van der Lee SJ, Williams J, et al. Association of MGMT and BIN1 genes with Alzheimer's disease risk across sex and APOE ε4 status. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 38041824 DOI: 10.1002/alz.13550 |
0.453 |
|
| 2023 |
Duchateau L, Küҫükali F, De Roeck A, Wittens MMJ, Temmerman J, Weets I, Timmers M, Engelborghs S, Bjerke M, Sleegers K. CSF biomarker analysis of ABCA7 mutation carriers suggests altered APP processing and reduced inflammatory response. Alzheimer's Research & Therapy. 15: 195. PMID 37946268 DOI: 10.1186/s13195-023-01338-y |
0.412 |
|
| 2023 |
Neumann A, Ohlei O, Küçükali F, Bos IJ, Timsina J, Vos S, Prokopenko D, Tijms BM, Andreasson U, Blennow K, Vandenberghe R, Scheltens P, Teunissen CE, Engelborghs S, Frisoni GB, ... ... Sleegers K, et al. Multivariate GWAS of Alzheimer's disease CSF biomarker profiles implies GRIN2D in synaptic functioning. Genome Medicine. 15: 79. PMID 37794492 DOI: 10.1186/s13073-023-01233-z |
0.461 |
|
| 2023 |
Tomé SO, Tsaka G, Ronisz A, Ospitalieri S, Gawor K, Gomes LA, Otto M, von Arnim CAF, Van Damme P, Van Den Bosch L, Ghebremedhin E, Laureyssen C, Sleegers K, Vandenberghe R, Rousseau F, et al. TDP-43 pathology is associated with increased tau burdens and seeding. Molecular Neurodegeneration. 18: 71. PMID 37777806 DOI: 10.1186/s13024-023-00653-0 |
0.408 |
|
| 2023 |
Colmant L, Bierbrauer A, Bellaali Y, Kunz L, Van Dongen J, Sleegers K, Axmacher N, Lefèvre P, Hanseeuw B. Dissociating effects of aging and genetic risk of sporadic Alzheimer's disease on path integration. Neurobiology of Aging. 131: 170-181. PMID 37672944 DOI: 10.1016/j.neurobiolaging.2023.07.025 |
0.352 |
|
| 2023 |
Le Guen Y, Luo G, Ambati A, Damotte V, Jansen I, Yu E, Nicolas A, de Rojas I, Peixoto Leal T, Miyashita A, Bellenguez C, Lian MM, Parveen K, Morizono T, Park H, ... ... Sleegers K, et al. Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by subtypes. Proceedings of the National Academy of Sciences of the United States of America. 120: e2302720120. PMID 37643212 DOI: 10.1073/pnas.2302720120 |
0.589 |
|
| 2023 |
Luo J, Thomassen JQ, Bellenguez C, Grenier-Boley B, de Rojas I, Castillo A, Parveen K, Küçükali F, Nicolas A, Peters O, Schneider A, Dichgans M, Rujescu D, Scherbaum N, Jürgen D, ... ... Sleegers K, et al. Genetic Associations Between Modifiable Risk Factors and Alzheimer Disease. Jama Network Open. 6: e2313734. PMID 37195665 DOI: 10.1001/jamanetworkopen.2023.13734 |
0.478 |
|
| 2023 |
Shi L, Xu J, Green R, Wretlind A, Homann J, Buckley NJ, Tijms BM, Vos SJB, Lill CM, Kate MT, Engelborghs S, Sleegers K, Frisoni GB, Wallin A, Lleó A, et al. Multiomics profiling of human plasma and cerebrospinal fluid reveals ATN-derived networks and highlights causal links in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 36790009 DOI: 10.1002/alz.12961 |
0.465 |
|
| 2023 |
de Rojas I, Moreno-Grau S, Tesi N, Grenier-Boley B, Andrade V, Jansen IE, Pedersen NL, Stringa N, Zettergren A, Hernández I, Montrreal L, Antúnez C, Antonell A, Tankard RM, Bis JC, ... ... Sleegers K, et al. Author Correction: Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nature Communications. 14: 716. PMID 36759603 DOI: 10.1038/s41467-023-36192-x |
0.511 |
|
| 2022 |
Küçükali F, Neumann A, Van Dongen J, De Pooter T, Joris G, De Rijk P, Ohlei O, Dobricic V, Bos I, Vos SJB, Engelborghs S, De Roeck E, Vandenberghe R, Gabel S, Meersmans K, ... ... Sleegers K, et al. Whole-exome rare-variant analysis of Alzheimer's disease and related biomarker traits. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 36464806 DOI: 10.1002/alz.12842 |
0.491 |
|
| 2022 |
Jansen IE, van der Lee SJ, Gomez-Fonseca D, de Rojas I, Dalmasso MC, Grenier-Boley B, Zettergren A, Mishra A, Ali M, Andrade V, Bellenguez C, Kleineidam L, Küçükali F, Sung YJ, Tesí N, ... ... Sleegers K, et al. Genome-wide meta-analysis for Alzheimer's disease cerebrospinal fluid biomarkers. Acta Neuropathologica. PMID 36066633 DOI: 10.1007/s00401-022-02454-z |
0.692 |
|
| 2022 |
Le Guen Y, Belloy ME, Grenier-Boley B, de Rojas I, Castillo-Morales A, Jansen I, Nicolas A, Bellenguez C, Dalmasso C, Küçükali F, Eger SJ, Rasmussen KL, Thomassen JQ, Deleuze JF, He Z, ... ... Sleegers K, et al. Association of Rare APOE Missense Variants V236E and R251G With Risk of Alzheimer Disease. Jama Neurology. PMID 35639372 DOI: 10.1001/jamaneurol.2022.1166 |
0.704 |
|
| 2022 |
Visser PJ, Reus LM, Gobom J, Jansen I, Dicks E, van der Lee SJ, Tsolaki M, Verhey FRJ, Popp J, Martinez-Lage P, Vandenberghe R, Lleó A, Molinuevo JL, Engelborghs S, Freund-Levi Y, ... ... Sleegers K, et al. Correction: Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease. Molecular Neurodegeneration. 17: 37. PMID 35550177 DOI: 10.1186/s13024-022-00540-0 |
0.306 |
|
| 2022 |
Homann J, Osburg T, Ohlei O, Dobricic V, Deecke L, Bos I, Vandenberghe R, Gabel S, Scheltens P, Teunissen CE, Engelborghs S, Frisoni G, Blin O, Richardson JC, Bordet R, ... ... Sleegers K, et al. Genome-Wide Association Study of Alzheimer's Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery Dataset. Frontiers in Aging Neuroscience. 14: 840651. PMID 35386118 DOI: 10.3389/fnagi.2022.840651 |
0.479 |
|
| 2022 |
Bellenguez C, Küçükali F, Jansen IE, Kleineidam L, Moreno-Grau S, Amin N, Naj AC, Campos-Martin R, Grenier-Boley B, Andrade V, Holmans PA, Boland A, Damotte V, van der Lee SJ, Costa MR, ... ... Sleegers K, et al. New insights into the genetic etiology of Alzheimer's disease and related dementias. Nature Genetics. PMID 35379992 DOI: 10.1038/s41588-022-01024-z |
0.717 |
|
| 2022 |
Visser PJ, Reus LM, Gobom J, Jansen I, Dicks E, van der Lee SJ, Tsolaki M, Verhey FRJ, Popp J, Martinez-Lage P, Vandenberghe R, Lleó A, Molinuevo JL, Engelborghs S, Freund-Levi Y, ... ... Sleegers K, et al. Cerebrospinal fluid tau levels are associated with abnormal neuronal plasticity markers in Alzheimer's disease. Molecular Neurodegeneration. 17: 27. PMID 35346299 DOI: 10.1186/s13024-022-00521-3 |
0.342 |
|
| 2022 |
Schaeverbeke J, Luckett ES, Gabel S, Reinartz M, De Meyer S, Cleynen I, Sleegers K, Van Broeckhoven C, Bormans G, Serdons K, Van Laere K, Dupont P, Vandenberghe R. Lack of association between bridging integrator 1 () rs744373 polymorphism and tau-PET load in cognitively intact older adults. Alzheimer's & Dementia (New York, N. Y.). 8: e12227. PMID 35229019 DOI: 10.1002/trc2.12227 |
0.379 |
|
| 2022 |
Neumann A, Küçükali F, Bos I, Vos SJB, Engelborghs S, De Pooter T, Joris G, De Rijk P, De Roeck E, Tsolaki M, Verhey F, Martinez-Lage P, Tainta M, Frisoni G, Blin O, ... ... Sleegers K, et al. Rare variants in IFFO1, DTNB, NLRC3 and SLC22A10 associate with Alzheimer's disease CSF profile of neuronal injury and inflammation. Molecular Psychiatry. PMID 35173266 DOI: 10.1038/s41380-022-01437-6 |
0.396 |
|
| 2022 |
Belloy ME, Eger SJ, Le Guen Y, Damotte V, Ahmad S, Ikram MA, Ramirez A, Tsolaki AC, Rossi G, Jansen IE, de Rojas I, Parveen K, Sleegers K, Ingelsson M, Hiltunen M, et al. Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping. Alzheimer's Research & Therapy. 14: 22. PMID 35120553 DOI: 10.1186/s13195-022-00962-4 |
0.477 |
|
| 2021 |
Xu J, Green R, Kim M, Lord J, Ebshiana A, Westwood S, Baird AL, Nevado-Holgado AJ, Shi L, Hye A, Snowden SG, Bos I, Vos SJB, Vandenberghe R, Teunissen CE, ... ... Sleegers K, et al. Sex-Specific Metabolic Pathways Were Associated with Alzheimer's Disease (AD) Endophenotypes in the European Medical Information Framework for AD Multimodal Biomarker Discovery Cohort. Biomedicines. 9. PMID 34829839 DOI: 10.3390/biomedicines9111610 |
0.387 |
|
| 2021 |
Shi L, Buckley NJ, Bos I, Engelborghs S, Sleegers K, Frisoni GB, Wallin A, Lléo A, Popp J, Martinez-Lage P, Legido-Quigley C, Barkhof F, Zetterberg H, Visser PJ, Bertram L, et al. Plasma Proteomic Biomarkers Relating to Alzheimer's Disease: A Meta-Analysis Based on Our Own Studies. Frontiers in Aging Neuroscience. 13: 712545. PMID 34366831 DOI: 10.3389/fnagi.2021.712545 |
0.424 |
|
| 2021 |
de Rojas I, Moreno-Grau S, Tesi N, Grenier-Boley B, Andrade V, Jansen IE, Pedersen NL, Stringa N, Zettergren A, Hernández I, Montrreal L, Antúnez C, Antonell A, Tankard RM, Bis JC, ... ... Sleegers K, et al. Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nature Communications. 12: 3417. PMID 34099642 DOI: 10.1038/s41467-021-22491-8 |
0.586 |
|
| 2021 |
Hong S, Dobricic V, Ohlei O, Bos I, Vos SJB, Prokopenko D, Tijms BM, Andreasson U, Blennow K, Vandenberghe R, Gabel S, Scheltens P, Teunissen CE, Engelborghs S, Frisoni G, ... ... Sleegers K, et al. TMEM106B and CPOX are genetic determinants of cerebrospinal fluid Alzheimer's disease biomarker levels. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33991015 DOI: 10.1002/alz.12330 |
0.356 |
|
| 2021 |
Shi L, Winchester LM, Westwood S, Baird AL, Anand SN, Buckley NJ, Hye A, Ashton NJ, Bos I, Vos SJB, Kate MT, Scheltens P, Teunissen CE, Vandenberghe R, Gabel S, ... ... Sleegers K, et al. Replication study of plasma proteins relating to Alzheimer's pathology. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33792144 DOI: 10.1002/alz.12322 |
0.365 |
|
| 2020 |
Hong S, Prokopenko D, Dobricic V, Kilpert F, Bos I, Vos SJB, Tijms BM, Andreasson U, Blennow K, Vandenberghe R, Cleynen I, Gabel S, Schaeverbeke J, Scheltens P, Teunissen CE, ... ... Sleegers K, et al. Genome-wide association study of Alzheimer's disease CSF biomarkers in the EMIF-AD Multimodal Biomarker Discovery dataset. Translational Psychiatry. 10: 403. PMID 33223526 DOI: 10.1038/s41398-020-01074-z |
0.506 |
|
| 2020 |
Visser PJ, Reus LM, Gobom J, Jansen I, Dicks E, Tsolaki M, Verhey FRJ, Popp J, Martinez-Lage P, Vandenberghe R, Lleó A, Molinuevo JL, Engelborghs S, Freund-Levi Y, Froelich L, ... Sleegers K, et al. Cerebrospinal fluid total tau levels indicate aberrant neuronal plasticity in Alzheimer's disease. Medrxiv : the Preprint Server For Health Sciences. PMID 33173883 DOI: 10.1101/2020.10.29.20211920 |
0.342 |
|
| 2020 |
Koçoğlu C, Gossye H, Dillen L, Van Mossevelde S, De Bleecker JL, Vandenberghe R, De Deyn PP, Sleegers K, Cras P, Engelborghs S, Van Broeckhoven C, van der Zee J. No association of CpG SNP rs9357140 with onset age in Belgian C9orf72 repeat expansion carriers. Neurobiology of Aging. PMID 32921502 DOI: 10.1016/J.Neurobiolaging.2020.07.021 |
0.334 |
|
| 2020 |
Perrone F, Bjerke M, Hens E, Sieben A, Timmers M, De Roeck A, Vandenberghe R, Sleegers K, Martin JJ, De Deyn PP, Engelborghs S, van der Zee J, Van Broeckhoven C, Cacace R. Amyloid-β cerebrospinal fluid levels and the interpretation of APP, PSEN1 and PSEN2 mutations. Alzheimer's Research & Therapy. 12: 108. PMID 32917274 DOI: 10.1186/S13195-020-00676-5 |
0.358 |
|
| 2020 |
Shi L, Winchester LM, Liu BY, Killick R, Ribe EM, Westwood S, Baird AL, Buckley NJ, Hong S, Dobricic V, Kilpert F, Franke A, Kiddle S, Sattlecker M, Dobson R, ... ... Sleegers K, et al. Dickkopf-1 Overexpression in vitro Nominates Candidate Blood Biomarkers Relating to Alzheimer's Disease Pathology. Journal of Alzheimer's Disease : Jad. PMID 32831200 DOI: 10.3233/Jad-200208 |
0.378 |
|
| 2020 |
Martins S, Müller-Schiffmann A, Erichsen L, Bohndorf M, Wruck W, Sleegers K, Van Broeckhoven C, Korth C, Adjaye J. IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory Network. International Journal of Molecular Sciences. 21. PMID 32630447 DOI: 10.3390/ijms21124516 |
0.405 |
|
| 2020 |
Sleegers K. Expression of ABCA7 in Alzheimer's disease. Acta Neuropathologica. 139: 941-942. PMID 32112170 DOI: 10.1007/s00401-020-02136-8 |
0.339 |
|
| 2020 |
Westwood S, Baird AL, Anand SN, Nevado-Holgado AJ, Kormilitzin A, Shi L, Hye A, Ashton NJ, Morgan AR, Bos I, Vos SJB, Baker S, Buckley NJ, Ten Kate M, Scheltens P, ... ... Sleegers K, et al. Validation of Plasma Proteomic Biomarkers Relating to Brain Amyloid Burden in the EMIF-Alzheimer's Disease Multimodal Biomarker Discovery Cohort. Journal of Alzheimer's Disease : Jad. PMID 31985466 DOI: 10.3233/Jad-190434 |
0.359 |
|
| 2020 |
Ando K, De Decker R, Vergara C, Yilmaz Z, Mansour S, Suain V, Sleegers K, de Fisenne MA, Houben S, Potier MC, Duyckaerts C, Watanabe T, Buée L, Leroy K, Brion JP. Picalm reduction exacerbates tau pathology in a murine tauopathy model. Acta Neuropathologica. PMID 31925534 DOI: 10.1007/S00401-020-02125-X |
0.339 |
|
| 2019 |
Stamate D, Kim M, Proitsi P, Westwood S, Baird A, Nevado-Holgado A, Hye A, Bos I, Vos SJB, Vandenberghe R, Teunissen CE, Kate MT, Scheltens P, Gabel S, Meersmans K, ... ... Sleegers K, et al. A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort. Alzheimer's & Dementia (New York, N. Y.). 5: 933-938. PMID 31890857 DOI: 10.1016/J.Trci.2019.11.001 |
0.336 |
|
| 2019 |
Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, et al. Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. PMID 31417202 DOI: 10.1038/s41588-019-0495-7 |
0.546 |
|
| 2019 |
Sleegers K, Van Broeckhoven C. Novel Alzheimer's disease risk genes: exhaustive investigation is paramount. Acta Neuropathologica. 138: 171-172. PMID 31300866 DOI: 10.1007/s00401-019-02041-9 |
0.415 |
|
| 2019 |
Kim M, Snowden S, Suvitaival T, Ali A, Merkler DJ, Ahmad T, Westwood S, Baird A, Proitsi P, Nevado-Holgado A, Hye A, Bos I, Vos S, Vandenberghe R, Teunissen C, ... ... Sleegers K, et al. Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 31078433 DOI: 10.1016/J.Jalz.2019.03.004 |
0.37 |
|
| 2019 |
De Roeck A, Van Broeckhoven C, Sleegers K. The role of ABCA7 in Alzheimer's disease: evidence from genomics, transcriptomics and methylomics. Acta Neuropathologica. 138: 201-220. PMID 30903345 DOI: 10.1007/s00401-019-01994-1 |
0.525 |
|
| 2019 |
Cacace R, Heeman B, Van Mossevelde S, De Roeck A, Hoogmartens J, De Rijk P, Gossye H, De Vos K, De Coster W, Strazisar M, De Baets G, Schymkowitz J, Rousseau F, Geerts N, De Pooter T, ... ... Sleegers K, et al. Loss of DPP6 in neurodegenerative dementia: a genetic player in the dysfunction of neuronal excitability. Acta Neuropathologica. PMID 30874922 DOI: 10.1007/S00401-019-01976-3 |
0.336 |
|
| 2019 |
Bos I, Vos S, Verhey F, Scheltens P, Teunissen C, Engelborghs S, Sleegers K, Frisoni G, Blin O, Richardson JC, Bordet R, Tsolaki M, Popp J, Peyratout G, Martinez-Lage P, et al. Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30853464 DOI: 10.1016/J.Jalz.2019.01.004 |
0.32 |
|
| 2019 |
Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. 51: 414-430. PMID 30820047 DOI: 10.1038/s41588-019-0358-2 |
0.585 |
|
| 2019 |
Sleegers K, Van Duijn CM. Alzheimer's Disease: Genes, Pathogenesis and Risk Prediction. Community Genetics. 4: 197-203. PMID 12107347 DOI: 10.1159/000064193 |
0.419 |
|
| 2019 |
De Roeck A, Van Broeckhoven C, Sleegers K. P4-093: TOWARDS AN IMPROVED UNDERSTANDING AND ASSESSMENT OF ABCA7
RISK ON ALZHEIMER'S DISEASE Alzheimer's & Dementia. 15: P1310-P1310. DOI: 10.1016/j.jalz.2019.06.3753 |
0.365 |
|
| 2018 |
Gusareva ES, Twizere JC, Sleegers K, Dourlen P, Abisambra JF, Meier S, Cloyd R, Weiss B, Dermaut B, Bessonov K, van der Lee SJ, Carrasquillo MM, Katsumata Y, Cherkaoui M, Asselbergh B, et al. Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease. Neurobiology of Aging. PMID 30201328 DOI: 10.1016/J.Neurobiolaging.2018.08.001 |
0.582 |
|
| 2018 |
Bos I, Vos S, Vandenberghe R, Scheltens P, Engelborghs S, Frisoni G, Molinuevo JL, Wallin A, Lleó A, Popp J, Martinez-Lage P, Baird A, Dobson R, Legido-Quigley C, Sleegers K, et al. The EMIF-AD Multimodal Biomarker Discovery study: design, methods and cohort characteristics. Alzheimer's Research & Therapy. 10: 64. PMID 29980228 DOI: 10.1186/S13195-018-0396-5 |
0.393 |
|
| 2018 |
Wauters E, Van Mossevelde S, Sleegers K, van der Zee J, Engelborghs S, Sieben A, Vandenberghe R, Philtjens S, Van den Broeck M, Peeters K, Cuijt I, De Coster W, Van Langenhove T, Santens P, Ivanoiu A, et al. Clinical variability and onset age modifiers in an extended Belgian GRN founder family. Neurobiology of Aging. 67: 84-94. PMID 29653316 DOI: 10.1016/J.Neurobiolaging.2018.03.007 |
0.326 |
|
| 2018 |
De Roeck A, Duchateau L, Van Dongen J, Cacace R, Bjerke M, Van den Bossche T, Cras P, Vandenberghe R, De Deyn PP, Engelborghs S, Van Broeckhoven C, Sleegers K. An intronic VNTR affects splicing of ABCA7 and increases risk of Alzheimer's disease. Acta Neuropathologica. PMID 29589097 DOI: 10.1007/S00401-018-1841-Z |
0.495 |
|
| 2018 |
Verheijen J, Sleegers K. Understanding Alzheimer Disease at the Interface between Genetics and Transcriptomics. Trends in Genetics : Tig. 34: 434-447. PMID 29573818 DOI: 10.1016/j.tig.2018.02.007 |
0.48 |
|
| 2018 |
Roeck AD, Duchateau L, Dongen JV, Cacace R, Bjerke M, Bossche TVd, Cras P, Vandenberghe R, Deyn PPD, Engelborghs S, Broeckhoven CV, Sleegers K. O4-01-01: In-Depth Analysis Of An Abca7 Vntr In Alzheimer'S Disease Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.2909 |
0.312 |
|
| 2017 |
Verheijen J, van der Zee J, Gijselinck I, Van den Bossche T, Dillen L, Heeman B, Gómez-Tortosa E, Lladó A, Sanchez-Valle R, Graff C, Pastor P, Pastor MA, Benussi L, Ghidoni R, Binetti G, ... ... Sleegers K, et al. Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort. Neurobiology of Aging. PMID 29146049 DOI: 10.1016/J.Neurobiolaging.2017.10.012 |
0.396 |
|
| 2017 |
Niemantsverdriet E, Ottoy J, Somers C, De Roeck E, Struyfs H, Soetewey F, Verhaeghe J, Van den Bossche T, Van Mossevelde S, Goeman J, De Deyn PP, Mariën P, Versijpt J, Sleegers K, Van Broeckhoven C, et al. The Cerebrospinal Fluid Aβ1-42/Aβ1-40 Ratio Improves Concordance with Amyloid-PET for Diagnosing Alzheimer's Disease in a Clinical Setting. Journal of Alzheimer's Disease : Jad. PMID 28869470 DOI: 10.3233/Jad-170327 |
0.311 |
|
| 2017 |
Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, ... Sleegers K, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. PMID 28714976 DOI: 10.1038/Ng.3916 |
0.607 |
|
| 2017 |
Thonberg H, Chiang HH, Lilius L, Forsell C, Lindström AK, Johansson C, Björkström J, Thordardottir S, Sleegers K, Van Broeckhoven C, Rönnbäck A, Graff C. Identification and description of three families with familial Alzheimer disease that segregate variants in the SORL1 gene. Acta Neuropathologica Communications. 5: 43. PMID 28595629 DOI: 10.1186/s40478-017-0441-9 |
0.374 |
|
| 2017 |
De Roeck A, Van den Bossche T, van der Zee J, Verheijen J, De Coster W, Van Dongen J, Dillen L, Baradaran-Heravi Y, Heeman B, Sanchez-Valle R, Lladó A, Nacmias B, Sorbi S, Gelpi E, Grau-Rivera O, ... ... Sleegers K, et al. Deleterious ABCA7 mutations and transcript rescue mechanisms in early onset Alzheimer's disease. Acta Neuropathologica. PMID 28447221 DOI: 10.1007/S00401-017-1714-X |
0.31 |
|
| 2016 |
Gusareva ES, Carrasquillo MM, Bellenguez C, Cuyvers E, Colon S, Graff-Radford NR, Petersen RC, Dickson DW, Mahachie John JM, Bessonov K, Van Broeckhoven C, Ramirez A, Harold D, Williams J, ... ... Sleegers K, et al. Corrigendum to "Genome-wide association interaction analysis for Alzheimer's disease." [Neurobiol. Aging 35 (2014) 2436-2443]. Neurobiology of Aging. 37: 211. PMID 28757004 DOI: 10.1016/J.Neurobiolaging.2015.11.015 |
0.329 |
|
| 2016 |
Schröter F, Sleegers K, Van Cauwenberghe C, Bohndorf M, Wruck W, Van Broeckhoven C, Adjaye J. Lymphoblast-derived integration-free iPSC lines from a female and male Alzheimer's disease patient expressing different copy numbers of a coding CNV in the Alzheimer risk gene CR1. Stem Cell Research. 17: 560-563. PMID 27789410 DOI: 10.1016/j.scr.2016.10.003 |
0.361 |
|
| 2016 |
Cuyvers E, Sleegers K. Genetic variations underlying Alzheimer's disease: evidence from genome-wide association studies and beyond. The Lancet. Neurology. 15: 857-868. PMID 27302364 DOI: 10.1016/S1474-4422(16)00127-7 |
0.468 |
|
| 2016 |
Verheijen J, Van den Bossche T, van der Zee J, Engelborghs S, Sanchez-Valle R, Lladó A, Graff C, Thonberg H, Pastor P, Ortega-Cubero S, Pastor MA, Benussi L, Ghidoni R, Binetti G, Clarimon J, ... ... Sleegers K, et al. A comprehensive study of the genetic impact of rare variants in SORL1 in European early-onset Alzheimer's disease. Acta Neuropathologica. PMID 27026413 DOI: 10.1007/S00401-016-1566-9 |
0.438 |
|
| 2016 |
Cacace R, Sleegers K, Van Broeckhoven C. Molecular genetics of early-onset Alzheimer's disease revisited. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 12: 733-48. PMID 27016693 DOI: 10.1016/j.jalz.2016.01.012 |
0.472 |
|
| 2016 |
Suárez-Calvet M, Kleinberger G, Araque Caballero MÁ, Brendel M, Rominger A, Alcolea D, Fortea J, Lleó A, Blesa R, Gispert JD, Sánchez-Valle R, Antonell A, Rami L, Molinuevo JL, Brosseron F, ... ... Sleegers K, et al. sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers. Embo Molecular Medicine. PMID 26941262 DOI: 10.15252/Emmm.201506123 |
0.409 |
|
| 2016 |
Van Cauwenberghe C, Van Broeckhoven C, Sleegers K. The genetic landscape of Alzheimer disease: clinical implications and perspectives. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 18: 421-30. PMID 26312828 DOI: 10.1038/gim.2015.117 |
0.446 |
|
| 2015 |
Struyfs H, Van Hecke W, Veraart J, Sijbers J, Slaets S, De Belder M, Wuyts L, Peters B, Sleegers K, Robberecht C, Van Broeckhoven C, De Belder F, Parizel PM, Engelborghs S. Diffusion Kurtosis Imaging: A Possible MRI Biomarker for AD Diagnosis? Journal of Alzheimer's Disease : Jad. 48: 937-48. PMID 26444762 DOI: 10.3233/Jad-150253 |
0.307 |
|
| 2015 |
Cacace R, Van den Bossche T, Engelborghs S, Geerts N, Laureys A, Dillen L, Graff C, Thonberg H, Chiang HH, Pastor P, Ortega-Cubero S, Pastor MA, Diehl-Schmid J, Alexopoulos P, Benussi L, ... ... Sleegers K, et al. Rare Variants in PLD3 do not Affect Risk for Early-Onset Alzheimer Disease in a European Consortium Cohort. Human Mutation. PMID 26411346 DOI: 10.1002/Humu.22908 |
0.432 |
|
| 2015 |
Bettens K, Vermeulen S, Van Cauwenberghe C, Heeman B, Asselbergh B, Robberecht C, Engelborghs S, Vandenbulcke M, Vandenberghe R, De Deyn PP, Cruts M, Van Broeckhoven C, Sleegers K. Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations. Molecular Neurodegeneration. 10: 30. PMID 26179372 DOI: 10.1186/S13024-015-0024-9 |
0.414 |
|
| 2015 |
Cuyvers E, De Roeck A, Van den Bossche T, Van Cauwenberghe C, Bettens K, Vermeulen S, Mattheijssens M, Peeters K, Engelborghs S, Vandenbulcke M, Vandenberghe R, De Deyn PP, Van Broeckhoven C, Sleegers K. Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients: a targeted resequencing study. The Lancet. Neurology. 14: 814-22. PMID 26141617 DOI: 10.1016/S1474-4422(15)00133-7 |
0.461 |
|
| 2015 |
Sleegers K, Bettens K, De Roeck A, Van Cauwenberghe C, Cuyvers E, Verheijen J, Struyfs H, Van Dongen J, Vermeulen S, Engelborghs S, Vandenbulcke M, Vandenberghe R, De Deyn PP, Van Broeckhoven C. A 22-single nucleotide polymorphism Alzheimer's disease risk score correlates with family history, onset age, and cerebrospinal fluid Aβ42. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 11: 1452-60. PMID 26086184 DOI: 10.1016/J.Jalz.2015.02.013 |
0.464 |
|
| 2015 |
Cuyvers E, van der Zee J, Bettens K, Engelborghs S, Vandenbulcke M, Robberecht C, Dillen L, Merlin C, Geerts N, Graff C, Thonberg H, Chiang HH, Pastor P, Ortega-Cubero S, Pastor MA, ... ... Sleegers K, et al. Genetic variability in SQSTM1 and risk of early-onset Alzheimer dementia: a European early-onset dementia consortium study. Neurobiology of Aging. 36: 2005.e15-22. PMID 25796131 DOI: 10.1016/J.Neurobiolaging.2015.02.014 |
0.517 |
|
| 2015 |
Struyfs H, Van Broeck B, Timmers M, Fransen E, Sleegers K, Van Broeckhoven C, De Deyn PP, Streffer JR, Mercken M, Engelborghs S. Diagnostic Accuracy of Cerebrospinal Fluid Amyloid-β Isoforms for Early and Differential Dementia Diagnosis. Journal of Alzheimer's Disease : Jad. 45: 813-22. PMID 25633670 DOI: 10.3233/Jad-141986 |
0.37 |
|
| 2015 |
Cacace R, Van den Bossche T, Engelborghs S, Vandenbulcke M, Vandenberghe R, De Deyn PP, Cras P, Sleegers K, Van Broeckhoven C. P3-017: Rare variants in PLD3
do not increase risk in a belgian cohort of early-onset Alzheimer dementia patients Alzheimer's & Dementia. 11: P626-P626. DOI: 10.1016/J.Jalz.2015.06.883 |
0.4 |
|
| 2014 |
Kleinberger G, Yamanishi Y, Suárez-Calvet M, Czirr E, Lohmann E, Cuyvers E, Struyfs H, Pettkus N, Wenninger-Weinzierl A, Mazaheri F, Tahirovic S, Lleó A, Alcolea D, Fortea J, Willem M, ... ... Sleegers K, et al. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Science Translational Medicine. 6: 243ra86. PMID 24990881 DOI: 10.1126/Scitranslmed.3009093 |
0.363 |
|
| 2014 |
Gusareva ES, Carrasquillo MM, Bellenguez C, Cuyvers E, Colon S, Graff-Radford NR, Petersen RC, Dickson DW, Mahachie John JM, Bessonov K, Van Broeckhoven C, Harold D, Williams J, Amouyel P, ... Sleegers K, et al. Genome-wide association interaction analysis for Alzheimer's disease. Neurobiology of Aging. 35: 2436-43. PMID 24958192 DOI: 10.1016/J.Neurobiolaging.2014.05.014 |
0.425 |
|
| 2014 |
Escott-Price V, Bellenguez C, Wang LS, Choi SH, Harold D, Jones L, Holmans P, Gerrish A, Vedernikov A, Richards A, DeStefano AL, Lambert JC, Ibrahim-Verbaas CA, Naj AC, Sims R, ... ... Sleegers K, et al. Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease. Plos One. 9: e94661. PMID 24922517 DOI: 10.1371/Journal.Pone.0094661 |
0.611 |
|
| 2014 |
Cuyvers E, Bettens K, Philtjens S, Van Langenhove T, Gijselinck I, van der Zee J, Engelborghs S, Vandenbulcke M, Van Dongen J, Geerts N, Maes G, Mattheijssens M, Peeters K, Cras P, Vandenberghe R, ... ... Sleegers K, et al. Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia. Neurobiology of Aging. 35: 726.e11-9. PMID 24119542 DOI: 10.1016/J.Neurobiolaging.2013.09.009 |
0.508 |
|
| 2014 |
Bettens K, Cauwenberghe CV, Cuyvers E, Verheijen J, Roeck AD, Dongen JV, Vermeulen S, Engelborghs S, Vandenbulcke M, Vandenberghe RR, Deyn PPD, Broeckhoven CV, Sleegers K. HIGH SCORES ON A 22-GENE RISK SCORE FOR ALZHEIMER'S DEMENTIA CORRELATE WITH EARLIER ONSET AGE AND REDUCED CSF Aβ Alzheimers & Dementia. 10: 257. DOI: 10.1016/J.Jalz.2014.04.404 |
0.391 |
|
| 2014 |
Cuyvers E, Bettens K, Engelborghs S, Vandenbulcke M, Merlin C, Dillen L, Mattheijssens M, Peeters K, Cras P, Vandenberghe RR, Deyn PD, Zee Jvd, Broeckhoven CV, Sleegers K. Analysis Of Sqstm1 In Patients With Early-Onset Alzheimer'S Disease Alzheimers & Dementia. 10. DOI: 10.1016/J.Jalz.2014.04.077 |
0.365 |
|
| 2013 |
Adamczuk K, De Weer AS, Nelissen N, Chen K, Sleegers K, Bettens K, Van Broeckhoven C, Vandenbulcke M, Thiyyagura P, Dupont P, Van Laere K, Reiman EM, Vandenberghe R. Polymorphism of brain derived neurotrophic factor influences β amyloid load in cognitively intact apolipoprotein E ε4 carriers. Neuroimage. Clinical. 2: 512-20. PMID 24179803 DOI: 10.1016/J.Nicl.2013.04.001 |
0.343 |
|
| 2013 |
Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thorton-Wells TA, Jones N, Smith AV, Chouraki V, ... ... Sleegers K, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nature Genetics. 45: 1452-8. PMID 24162737 DOI: 10.1038/Ng.2802 |
0.534 |
|
| 2013 |
Slaets S, Le Bastard N, Martin JJ, Sleegers K, Van Broeckhoven C, De Deyn PP, Engelborghs S. Cerebrospinal fluid Aβ1-40 improves differential dementia diagnosis in patients with intermediate P-tau181P levels. Journal of Alzheimer's Disease : Jad. 36: 759-67. PMID 23666174 DOI: 10.3233/Jad-130107 |
0.373 |
|
| 2013 |
Van Cauwenberghe C, Bettens K, Engelborghs S, Vandenbulcke M, Van Dongen J, Vermeulen S, Vandenberghe R, De Deyn PP, Van Broeckhoven C, Sleegers K. Complement receptor 1 coding variant p.Ser1610Thr in Alzheimer's disease and related endophenotypes. Neurobiology of Aging. 34: 2235.e1-6. PMID 23582656 DOI: 10.1016/J.Neurobiolaging.2013.03.008 |
0.456 |
|
| 2013 |
Chapuis J, Hansmannel F, Gistelinck M, Mounier A, Van Cauwenberghe C, Kolen KV, Geller F, Sottejeau Y, Harold D, Dourlen P, Grenier-Boley B, Kamatani Y, Delepine B, Demiautte F, Zelenika D, ... ... Sleegers K, et al. Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology. Molecular Psychiatry. 18: 1225-34. PMID 23399914 DOI: 10.1038/Mp.2013.1 |
0.463 |
|
| 2013 |
Slaets S, Le Bastard N, Theuns J, Sleegers K, Verstraeten A, De Leenheir E, Luyckx J, Martin JJ, Van Broeckhoven C, Engelborghs S. Amyloid pathology influences aβ1-42 cerebrospinal fluid levels in dementia with lewy bodies. Journal of Alzheimer's Disease : Jad. 35: 137-46. PMID 23364139 DOI: 10.3233/Jad-122176 |
0.38 |
|
| 2013 |
Cacace R, Van Cauwenberghe C, Bettens K, Gijselinck I, van der Zee J, Engelborghs S, Vandenbulcke M, Van Dongen J, Bäumer V, Dillen L, Mattheijssens M, Peeters K, Cruts M, Vandenberghe R, De Deyn PP, ... ... Sleegers K, et al. C9orf72 G4C2 repeat expansions in Alzheimer's disease and mild cognitive impairment. Neurobiology of Aging. 34: 1712.e1-7. PMID 23352322 DOI: 10.1016/J.Neurobiolaging.2012.12.019 |
0.455 |
|
| 2013 |
Engelborghs S, Sleegers K, Van der Mussele S, Le Bastard N, Brouwers N, Van Broeckhoven C, De Deyn PP. Brain-specific tryptophan hydroxylase, TPH2, and 5-HTTLPR are associated with frontal lobe symptoms in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 35: 67-73. PMID 23334703 DOI: 10.3233/Jad-101305 |
0.413 |
|
| 2013 |
Bettens K, Sleegers K, Van Broeckhoven C. Genetic insights in Alzheimer's disease. The Lancet. Neurology. 12: 92-104. PMID 23237904 DOI: 10.1016/S1474-4422(12)70259-4 |
0.386 |
|
| 2013 |
Le Bastard N, Aerts L, Sleegers K, Martin JJ, Van Broeckhoven C, De Deyn PP, Engelborghs S. Longitudinal stability of cerebrospinal fluid biomarker levels: fulfilled requirement for pharmacodynamic markers in Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 33: 807-22. PMID 23034521 DOI: 10.3233/JAD-2012-110029 |
0.372 |
|
| 2013 |
Lambert JC, Grenier-Boley B, Harold D, Zelenika D, Chouraki V, Kamatani Y, Sleegers K, Ikram MA, Hiltunen M, Reitz C, Mateo I, Feulner T, Bullido M, Galimberti D, Concari L, et al. Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease. Molecular Psychiatry. 18: 461-70. PMID 22430674 DOI: 10.1038/Mp.2012.14 |
0.5 |
|
| 2013 |
Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, ... ... Sleegers K, et al. Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease Nature Genetics. 45: 712-712. DOI: 10.1038/Ng0613-712A |
0.373 |
|
| 2013 |
Lambert JC, Grenier-Boley B, Harold D, Zelenika D, Chouraki V, Kamatani Y, Sleegers K, Ikram MA, Hiltunen M, Reitz C, Mateo I, Feulner T, Bullido M, Galimberti D, Concari L, et al. Erratum: Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease (Molecular Psychiatry (2013) 18 (521) DOI: 10.1038/mp.2012.75)) Molecular Psychiatry. 18. DOI: 10.1038/Mp.2012.75 |
0.432 |
|
| 2012 |
Hazrati LN, Van Cauwenberghe C, Brooks PL, Brouwers N, Ghani M, Sato C, Cruts M, Sleegers K, St George-Hyslop P, Van Broeckhoven C, Rogaeva E. Genetic association of CR1 with Alzheimer's disease: a tentative disease mechanism. Neurobiology of Aging. 33: 2949.e5-2949.e12. PMID 22819390 DOI: 10.1016/J.Neurobiolaging.2012.07.001 |
0.317 |
|
| 2012 |
Bettens K, Brouwers N, Engelborghs S, Lambert JC, Rogaeva E, Vandenberghe R, Le Bastard N, Pasquier F, Vermeulen S, Van Dongen J, Mattheijssens M, Peeters K, Mayeux R, St George-Hyslop P, Amouyel P, ... ... Sleegers K, et al. Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk. Molecular Neurodegeneration. 7: 3. PMID 22248099 DOI: 10.1186/1750-1326-7-3 |
0.46 |
|
| 2012 |
Brouwers N, Van Cauwenberghe C, Engelborghs S, Lambert JC, Bettens K, Le Bastard N, Pasquier F, Montoya AG, Peeters K, Mattheijssens M, Vandenberghe R, Deyn PP, Cruts M, Amouyel P, Sleegers K, et al. Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites. Molecular Psychiatry. 17: 223-33. PMID 21403675 DOI: 10.1038/Mp.2011.24 |
0.391 |
|
| 2012 |
Sleegers K. S1-01-02: Comprehensive molecular genetic analysis of Alzheimer's risk loci Alzheimer's & Dementia. 8: P78-P78. DOI: 10.1016/j.jalz.2012.05.183 |
0.361 |
|
| 2012 |
Bettens K, Cauwenberghe CV, Cuyvers E, Bastard NL, Engelborghs S, Vandenberghe R, Deyn PD, Broeckhoven CV, Sleegers K. Genetic association and interaction of Alzheimer's risk genes CLU, CR1, BIN1, PICALM and MS4A in a Flanders-Belgian cohort Alzheimers & Dementia. 8: 671. DOI: 10.1016/J.Jalz.2012.05.1815 |
0.382 |
|
| 2011 |
Genin E, Hannequin D, Wallon D, Sleegers K, Hiltunen M, Combarros O, Bullido MJ, Engelborghs S, De Deyn P, Berr C, Pasquier F, Dubois B, Tognoni G, Fiévet N, Brouwers N, et al. APOE and Alzheimer disease: a major gene with semi-dominant inheritance. Molecular Psychiatry. 16: 903-7. PMID 21556001 DOI: 10.1038/Mp.2011.52 |
0.448 |
|
| 2011 |
Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, ... ... Sleegers K, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nature Genetics. 43: 429-35. PMID 21460840 DOI: 10.1038/Ng.803 |
0.469 |
|
| 2011 |
van der Zee J, Van Langenhove T, Kleinberger G, Sleegers K, Engelborghs S, Vandenberghe R, Santens P, Van den Broeck M, Joris G, Brys J, Mattheijssens M, Peeters K, Cras P, De Deyn PP, Cruts M, et al. TMEM106B is associated with frontotemporal lobar degeneration in a clinically diagnosed patient cohort. Brain : a Journal of Neurology. 134: 808-15. PMID 21354975 DOI: 10.1093/Brain/Awr007 |
0.372 |
|
| 2011 |
Reitz C, Cheng R, Rogaeva E, Lee JH, Tokuhiro S, Zou F, Bettens K, Sleegers K, Tan EK, Kimura R, Shibata N, Arai H, Kamboh MI, Prince JA, Maier W, et al. Meta-analysis of the association between variants in SORL1 and Alzheimer disease. Archives of Neurology. 68: 99-106. PMID 21220680 DOI: 10.1001/Archneurol.2010.346 |
0.434 |
|
| 2011 |
Rollinson S, Rohrer JD, van der Zee J, Sleegers K, Mead S, Engelborghs S, Collinge J, De Deyn PP, Mann DM, Van Broeckhoven C, Pickering-Brown SM. No association of PGRN 3'UTR rs5848 in frontotemporal lobar degeneration. Neurobiology of Aging. 32: 754-5. PMID 19446372 DOI: 10.1016/J.Neurobiolaging.2009.04.009 |
0.311 |
|
| 2010 |
Lambert JC, Sleegers K, González-Pérez A, Ingelsson M, Beecham GW, Hiltunen M, Combarros O, Bullido MJ, Brouwers N, Bettens K, Berr C, Pasquier F, Richard F, Dekosky ST, Hannequin D, et al. The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study. Journal of Alzheimer's Disease : Jad. 22: 247-55. PMID 20847397 DOI: 10.3233/Jad-2010-100933 |
0.528 |
|
| 2010 |
Brouwers N, Bettens K, Gijselinck I, Engelborghs S, Pickut BA, Van Miegroet H, Montoya AG, Mattheijssens M, Peeters K, De Deyn PP, Cruts M, Sleegers K, Van Broeckhoven C. Contribution of TARDBP to Alzheimer's disease genetic etiology. Journal of Alzheimer's Disease : Jad. 21: 423-30. PMID 20555136 DOI: 10.3233/Jad-2010-100198 |
0.417 |
|
| 2010 |
Bettens K, Sleegers K, Van Broeckhoven C. Current status on Alzheimer disease molecular genetics: from past, to present, to future. Human Molecular Genetics. 19: R4-R11. PMID 20388643 DOI: 10.1093/hmg/ddq142 |
0.483 |
|
| 2010 |
Sleegers K, Brouwers N, Van Broeckhoven C. Role of progranulin as a biomarker for Alzheimer's disease. Biomarkers in Medicine. 4: 37-50. PMID 20387302 DOI: 10.2217/bmm.09.82 |
0.389 |
|
| 2010 |
Bettens K, Brouwers N, Van Miegroet H, Gil A, Engelborghs S, De Deyn PP, Vandenberghe R, Van Broeckhoven C, Sleegers K. Follow-up study of susceptibility loci for Alzheimer's disease and onset age identified by genome-wide association. Journal of Alzheimer's Disease : Jad. 19: 1169-75. PMID 20308783 DOI: 10.3233/Jad-2010-1310 |
0.527 |
|
| 2010 |
Sleegers K, Lambert JC, Bertram L, Cruts M, Amouyel P, Van Broeckhoven C. The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects. Trends in Genetics : Tig. 26: 84-93. PMID 20080314 DOI: 10.1016/j.tig.2009.12.004 |
0.468 |
|
| 2010 |
Liu F, Pardo LM, Schuur M, Sanchez-Juan P, Isaacs A, Sleegers K, de Koning I, Zorkoltseva IV, Axenovich TI, Witteman JC, Janssens AC, van Swieten JC, Aulchenko YS, Oostra BA, van Duijn CM. The apolipoprotein E gene and its age-specific effects on cognitive function. Neurobiology of Aging. 31: 1831-3. PMID 19004527 DOI: 10.1016/j.neurobiolaging.2008.09.015 |
0.64 |
|
| 2010 |
Reitz C, Cheng R, Rogaeva E, Lee J, Tokuhiro S, Bettens K, Sleegers K, Tan EK, Kimura R, Shibata N, Kamboh IM, Prince J, Maier W, Riemenschneider M, Owen M, et al. Meta-analysis of the association between SORL1 variants and Alzheimer's disease Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.351 |
0.424 |
|
| 2010 |
Bettens K, Brouwers N, Gil A, Miegroet HV, Engelborghs S, Deyn PPD, Vandenberghe R, Sleegers K, Broeckhoven CV. In-depth molecular genetic analysis of CLU in Alzheimer's disease Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.217 |
0.377 |
|
| 2009 |
Lambert JC, Heath S, Even G, Campion D, Sleegers K, Hiltunen M, Combarros O, Zelenika D, Bullido MJ, Tavernier B, Letenneur L, Bettens K, Berr C, Pasquier F, Fiévet N, et al. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nature Genetics. 41: 1094-9. PMID 19734903 DOI: 10.1038/Ng.439 |
0.466 |
|
| 2009 |
Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, ... ... Sleegers K, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nature Genetics. 41: 1088-93. PMID 19734902 DOI: 10.1038/Ng.440 |
0.405 |
|
| 2009 |
Liu F, Ikram MA, Janssens AC, Schuur M, de Koning I, Isaacs A, Struchalin M, Uitterlinden AG, den Dunnen JT, Sleegers K, Bettens K, Van Broeckhoven C, van Swieten J, Hofman A, Oostra BA, et al. A study of the SORL1 gene in Alzheimer's disease and cognitive function. Journal of Alzheimer's Disease : Jad. 18: 51-64. PMID 19584446 DOI: 10.3233/Jad-2009-1137 |
0.708 |
|
| 2009 |
Bettens K, Brouwers N, Engelborghs S, Van Miegroet H, De Deyn PP, Theuns J, Sleegers K, Van Broeckhoven C. APP and BACE1 miRNA genetic variability has no major role in risk for Alzheimer disease. Human Mutation. 30: 1207-13. PMID 19462468 DOI: 10.1002/Humu.21027 |
0.364 |
|
| 2009 |
Sleegers K, Brouwers N, Bettens K, Engelborghs S, van Miegroet H, De Deyn PP, Van Broeckhoven C. No association between CALHM1 and risk for Alzheimer dementia in a Belgian population. Human Mutation. 30: E570-4. PMID 19191332 DOI: 10.1002/Humu.20990 |
0.507 |
|
| 2009 |
Sleegers K, Bettens K, Brouwers N, Engelborghs S, van Miegroet H, De Deyn PP, Van Broeckhoven C. Common variation in GRB-associated Binding Protein 2 (GAB2) and increased risk for Alzheimer dementia. Human Mutation. 30: E338-44. PMID 18853460 DOI: 10.1002/Humu.20909 |
0.481 |
|
| 2009 |
Brouwers N, Sleegers K, Van Broeckhoven C. Molecular genetics of Alzheimer's disease: an update. Annals of Medicine. 40: 562-83. PMID 18608129 DOI: 10.1080/07853890802186905 |
0.489 |
|
| 2009 |
Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, ... ... Sleegers K, et al. Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease Nature Genetics. 41: 1156-1156. DOI: 10.1038/Ng1009-1156D |
0.373 |
|
| 2008 |
van der Zee J, Sleegers K, Van Broeckhoven C. Invited article: the Alzheimer disease-frontotemporal lobar degeneration spectrum. Neurology. 71: 1191-7. PMID 18838666 DOI: 10.1212/01.wnl.0000327523.52537.86 |
0.449 |
|
| 2008 |
Brouwers N, Sleegers K, Engelborghs S, Maurer-Stroh S, Gijselinck I, van der Zee J, Pickut BA, Van den Broeck M, Mattheijssens M, Peeters K, Schymkowitz J, Rousseau F, Martin JJ, Cruts M, De Deyn PP, et al. Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease. Neurology. 71: 656-64. PMID 18565828 DOI: 10.1212/01.Wnl.0000319688.89790.7A |
0.468 |
|
| 2008 |
Bettens K, Brouwers N, Engelborghs S, De Deyn PP, Van Broeckhoven C, Sleegers K. SORL1 is genetically associated with increased risk for late-onset Alzheimer disease in the Belgian population. Human Mutation. 29: 769-70. PMID 18407551 DOI: 10.1002/Humu.20725 |
0.505 |
|
| 2008 |
Bettens K, Brouwers N, Engelborghs S, De Pooter T, De Deyn PP, Sleegers K, Van Broeckhoven C. DNMBP is genetically associated with Alzheimer dementia in the Belgian population. Neurobiology of Aging. 30: 2000-9. PMID 18359537 DOI: 10.1016/J.Neurobiolaging.2008.02.003 |
0.464 |
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| 2008 |
Arias-Vásquez A, Aulchenko YS, Isaacs A, van Oosterhout A, Sleegers K, Hofman A, van Broeckhoven C, Oostra BA, Breteler M, van Duijn CM. Cyclin-dependent kinase 5 is associated with risk for Alzheimer's disease in a Dutch population-based study. Journal of Neurology. 255: 655-62. PMID 18350355 DOI: 10.1007/S00415-008-0770-5 |
0.71 |
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| 2008 |
Persson J, Lind J, Larsson A, Ingvar M, Sleegers K, Van Broeckhoven C, Adolfsson R, Nilsson LG, Nyberg L. Altered deactivation in individuals with genetic risk for Alzheimer's disease. Neuropsychologia. 46: 1679-87. PMID 18346764 DOI: 10.1016/J.Neuropsychologia.2008.01.026 |
0.344 |
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| 2008 |
Sleegers K, Bettens K, Engelborghs S, Brouwers N, van Miegroet H, De Deyn PP, Van Broeckhoven C. P3-266: GAB2 and risk for Alzheimer's dementia in a Belgian population Alzheimer's & Dementia. 4: T600-T600. DOI: 10.1016/J.Jalz.2008.05.1834 |
0.384 |
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| 2008 |
Bettens K, Brouwers N, Engelborghs S, De Deyn P, Van Broeckhoven C, Sleegers K. P3-202: The neuronal sorting receptor SORL1 is genetically associated with increased risk for late-onset Alzheimer's disease in the Belgian population Alzheimer's & Dementia. 4: T579-T580. DOI: 10.1016/J.Jalz.2008.05.1769 |
0.362 |
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| 2007 |
Brouwers N, Nuytemans K, van der Zee J, Gijselinck I, Engelborghs S, Theuns J, Kumar-Singh S, Pickut BA, Pals P, Dermaut B, Bogaerts V, De Pooter T, Serneels S, Van den Broeck M, Cuijt I, ... ... Sleegers K, et al. Alzheimer and Parkinson diagnoses in progranulin null mutation carriers in an extended founder family. Archives of Neurology. 64: 1436-46. PMID 17923627 DOI: 10.1001/Archneur.64.10.1436 |
0.311 |
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| 2007 |
Bogaerts V, Engelborghs S, Kumar-Singh S, Goossens D, Pickut B, van der Zee J, Sleegers K, Peeters K, Martin JJ, Del-Favero J, Gasser T, Dickson DW, Wszolek ZK, De Deyn PP, Theuns J, et al. A novel locus for dementia with Lewy bodies: a clinically and genetically heterogeneous disorder. Brain : a Journal of Neurology. 130: 2277-91. PMID 17681982 DOI: 10.1093/Brain/Awm167 |
0.336 |
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| 2007 |
Liu F, Arias-Vásquez A, Sleegers K, Aulchenko YS, Kayser M, Sanchez-Juan P, Feng BJ, Bertoli-Avella AM, van Swieten J, Axenovich TI, Heutink P, van Broeckhoven C, Oostra BA, van Duijn CM. A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population. American Journal of Human Genetics. 81: 17-31. PMID 17564960 DOI: 10.1086/518720 |
0.66 |
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| 2007 |
Wollmer MA, Sleegers K, Ingelsson M, Zekanowski C, Brouwers N, Maruszak A, Brunner F, Huynh KD, Kilander L, Brundin RM, Hedlund M, Giedraitis V, Glaser A, Engelborghs S, De Deyn PP, et al. Association study of cholesterol-related genes in Alzheimer's disease. Neurogenetics. 8: 179-88. PMID 17387528 DOI: 10.1007/S10048-007-0087-Z |
0.486 |
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| 2006 |
Brouwers N, Sleegers K, Engelborghs S, Bogaerts V, Serneels S, Kamali K, Corsmit E, De Leenheir E, Martin JJ, De Deyn PP, Van Broeckhoven C, Theuns J. Genetic risk and transcriptional variability of amyloid precursor protein in Alzheimer's disease. Brain : a Journal of Neurology. 129: 2984-91. PMID 16931535 DOI: 10.1093/Brain/Awl212 |
0.347 |
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| 2006 |
Sleegers K, Brouwers N, Gijselinck I, Theuns J, Goossens D, Wauters J, Del-Favero J, Cruts M, van Duijn CM, Van Broeckhoven C. APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy. Brain : a Journal of Neurology. 129: 2977-83. PMID 16921174 DOI: 10.1093/Brain/Awl203 |
0.551 |
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| 2006 |
Sleegers K, de Koning I, Aulchenko YS, van Rijn MJ, Houben MP, Croes EA, van Swieten JC, Oostra BA, van Duijn CM. Cerebrovascular risk factors do not contribute to genetic variance of cognitive function: the ERF study. Neurobiology of Aging. 28: 735-41. PMID 16698126 DOI: 10.1016/j.neurobiolaging.2006.03.012 |
0.493 |
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| 2006 |
Theuns J, Brouwers N, Engelborghs S, Sleegers K, Bogaerts V, Corsmit E, De Pooter T, van Duijn CM, De Deyn PP, Van Broeckhoven C. Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease. American Journal of Human Genetics. 78: 936-46. PMID 16685645 DOI: 10.1086/504044 |
0.511 |
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| 2006 |
Lind J, Larsson A, Persson J, Ingvar M, Nilsson LG, Bäckman L, Adolfsson R, Cruts M, Sleegers K, Van Broeckhoven C, Nyberg L. Reduced hippocampal volume in non-demented carriers of the apolipoprotein E epsilon4: relation to chronological age and recognition memory. Neuroscience Letters. 396: 23-7. PMID 16406347 DOI: 10.1016/J.Neulet.2005.11.070 |
0.345 |
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| 2006 |
Brouwers N, Sleegers K, Engelborghs S, Bogaerts V, van Duijn CM, De Deyn PP, Van Broeckhoven C, Dermaut B. The UBQLN1 polymorphism, UBQ-8i, at 9q22 is not associated with Alzheimer's disease with onset before 70 years. Neuroscience Letters. 392: 72-4. PMID 16214290 DOI: 10.1016/J.Neulet.2005.08.064 |
0.627 |
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| 2006 |
Liu F, Arias-Vásquez A, Aulchenko YS, Sleegers K, Sanchez-Juan P, Bertoli-Avella AM, Jian Feng B, Isaacs A, Heutink P, van Broeckhoven C, Oostra BA, van Duijn CM. O2-02-03: Linkage-based full genome scan for late onset Alzheimer's disease in a genetically isolated population Alzheimer's & Dementia. 2: S32-S32. DOI: 10.1016/j.jalz.2006.05.113 |
0.511 |
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| 2005 |
Rademakers R, Cruts M, Sleegers K, Dermaut B, Theuns J, Aulchenko Y, Weckx S, De Pooter T, Van den Broeck M, Corsmit E, De Rijk P, Del-Favero J, van Swieten J, van Duijn CM, Van Broeckhoven C. Linkage and association studies identify a novel locus for Alzheimer disease at 7q36 in a Dutch population-based sample. American Journal of Human Genetics. 77: 643-52. PMID 16175510 DOI: 10.1086/491749 |
0.662 |
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| 2005 |
Lehmann DJ, Cortina-Borja M, Warden DR, Smith AD, Sleegers K, Prince JA, van Duijn CM, Kehoe PG. Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's disease. American Journal of Epidemiology. 162: 305-17. PMID 16033878 DOI: 10.1093/aje/kwi202 |
0.6 |
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| 2005 |
Sleegers K, den Heijer T, van Dijk EJ, Hofman A, Bertoli-Avella AM, Koudstaal PJ, Breteler MM, van Duijn CM. ACE gene is associated with Alzheimer's disease and atrophy of hippocampus and amygdala. Neurobiology of Aging. 26: 1153-9. PMID 15917098 DOI: 10.1016/J.Neurobiolaging.2004.09.011 |
0.616 |
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| 2005 |
Rademakers R, Sleegers K, Theuns J, Van den Broeck M, Bel Kacem S, Nilsson LG, Adolfsson R, van Duijn CM, Van Broeckhoven C, Cruts M. Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease. Neurobiology of Aging. 26: 1145-51. PMID 15917097 DOI: 10.1016/J.Neurobiolaging.2004.10.003 |
0.451 |
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| 2004 |
Arias Vásquez A, Sleegers K, Dekker MC, van Gool WA, van Swieten JC, Aulchenko YS, Oostra BA, van Duijn CM. A deletion in DJ-1 and the risk of dementia--a population-based survey. Neuroscience Letters. 372: 196-9. PMID 15542239 DOI: 10.1016/j.neulet.2004.09.040 |
0.68 |
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| 2004 |
Croes EA, Theuns J, Houwing-Duistermaat JJ, Dermaut B, Sleegers K, Roks G, Van den Broeck M, van Harten B, van Swieten JC, Cruts M, Van Broeckhoven C, van Duijn CM. Octapeptide repeat insertions in the prion protein gene and early onset dementia. Journal of Neurology, Neurosurgery, and Psychiatry. 75: 1166-70. PMID 15258222 DOI: 10.1136/Jnnp.2003.020198 |
0.353 |
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| 2004 |
Sleegers K, Roks G, Theuns J, Aulchenko YS, Rademakers R, Cruts M, van Gool WA, Van Broeckhoven C, Heutink P, Oostra BA, van Swieten JC, van Duijn CM. Familial clustering and genetic risk for dementia in a genetically isolated Dutch population. Brain : a Journal of Neurology. 127: 1641-9. PMID 15130954 DOI: 10.1093/brain/awh179 |
0.61 |
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| 2004 |
Sleegers K, Koning Id, Aulchenko YS, Croes EA, van Swieten JC, Oostra BA, van Duijn CM. P4-162 Heritability of cognitive function in later adult life in a single extended pedigree Neurobiology of Aging. 25: S521-S522. DOI: 10.1016/S0197-4580(04)81720-2 |
0.376 |
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| 2004 |
Arias A, Aulchenko YS, Sleegers K, Roks G, Cruts M, Van Broeckhoven C, van Swieten JC, Heutink P, Oostra BA, van Duijn CM. O3-02-07 Linkage analysis for AD using amyloid beta 42 levels shows evidence for a novel AD gene on chromosome 19 Neurobiology of Aging. 25: S56. DOI: 10.1016/S0197-4580(04)80189-1 |
0.524 |
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| 2002 |
Rademakers R, Cruts M, Dermaut B, Sleegers K, Rosso SM, Van den Broeck M, Backhovens H, van Swieten J, van Duijn CM, Van Broeckhoven C. Tau negative frontal lobe dementia at 17q21: significant finemapping of the candidate region to a 4.8 cM interval. Molecular Psychiatry. 7: 1064-74. PMID 12476321 DOI: 10.1038/Sj.Mp.4001198 |
0.353 |
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| 2002 |
Dermaut B, Theuns J, Sleegers K, Hasegawa H, Van den Broeck M, Vennekens K, Corsmit E, St George-Hyslop P, Cruts M, van Duijn CM, Van Broeckhoven C. The gene encoding nicastrin, a major gamma-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample. American Journal of Human Genetics. 70: 1568-74. PMID 11992262 DOI: 10.1086/340732 |
0.531 |
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