| Year |
Citation |
Score |
| 2024 |
Misra J, Carlson KR, Spandau DF, Wek RC. Multiple mechanisms activate GCN2 eIF2 kinase in response to diverse stress conditions. Nucleic Acids Research. PMID 38281137 DOI: 10.1093/nar/gkae006 |
0.522 |
|
| 2023 |
Holmes MJ, Bastos MS, Dey V, Severo V, Wek RC, Sullivan WJ. mRNA cap-binding protein eIF4E1 is a novel regulator of latency. Biorxiv : the Preprint Server For Biology. PMID 37873335 DOI: 10.1101/2023.10.09.561274 |
0.416 |
|
| 2023 |
Levy JL, Mirek ET, Rodriguez EM, Zalma B, Burns J, Jonsson WO, Sampath H, Staschke KA, Wek RC, Anthony TG. GCN2 is required to maintain core body temperature in mice during acute cold. American Journal of Physiology. Endocrinology and Metabolism. PMID 37792040 DOI: 10.1152/ajpendo.00181.2023 |
0.722 |
|
| 2023 |
Wek RC, Anthony TG, Staschke KA. Surviving and adapting to stress: Translational control and the integrated stress response. Antioxidants & Redox Signaling. PMID 36943285 DOI: 10.1089/ars.2022.0123 |
0.798 |
|
| 2023 |
Carlson KR, Georgiadis MM, Tameire F, Staschke KA, Wek RC. Activation of Gcn2 by small molecules designed to be inhibitors. The Journal of Biological Chemistry. 299: 104595. PMID 36898579 DOI: 10.1016/j.jbc.2023.104595 |
0.79 |
|
| 2022 |
Amin PH, Carlson KR, Wek RC. An RNA stem-loop functions in conjunction with an upstream open reading frame to direct preferential translation in the integrated stress response. The Journal of Biological Chemistry. 102864. PMID 36596357 DOI: 10.1016/j.jbc.2022.102864 |
0.47 |
|
| 2022 |
Srivastava S, Jiang J, Misra J, Seim G, Staschke KA, Zhong M, Zhou L, Liu Y, Chen C, Davé U, Kapur R, Batra S, Zhang C, Zhou J, Fan J, ... Wek RC, et al. Asparagine bioavailability regulates the translation of MYC oncogene. Oncogene. PMID 36182969 DOI: 10.1038/s41388-022-02474-9 |
0.724 |
|
| 2022 |
Cordova RA, Misra J, Amin PH, Klunk AJ, Damayanti NP, Carlson KR, Elmendorf AJ, Kim HG, Mirek ET, Elzey BD, Miller MJ, Dong XC, Cheng L, Anthony TG, Pili R, ... Wek RC, et al. GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis. Elife. 11. PMID 36107759 DOI: 10.7554/eLife.81083 |
0.705 |
|
| 2022 |
Holmes MJ, Misra J, Wek RC. Analysis of Translational Control in the Integrated Stress Response by Polysome Profiling. Methods in Molecular Biology (Clifton, N.J.). 2428: 157-171. PMID 35171479 DOI: 10.1007/978-1-0716-1975-9_10 |
0.518 |
|
| 2021 |
Jin D, Wek SA, Kudlapur NT, Cantara WA, Bakhtina M, Wek RC, Musier-Forsyth K. Disease-associated mutations in a bifunctional aminoacyl-tRNA synthetase gene elicit the integrated stress response. The Journal of Biological Chemistry. 101203. PMID 34537243 DOI: 10.1016/j.jbc.2021.101203 |
0.309 |
|
| 2021 |
Misra J, Holmes MJ, T Mirek E, Langevin M, Kim HG, Carlson KR, Watford M, Dong XC, Anthony TG, Wek RC. Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress. Nucleic Acids Research. PMID 34023907 DOI: 10.1093/nar/gkab362 |
0.425 |
|
| 2021 |
Augusto L, Martynowicz J, Amin PH, Carlson KR, Wek RC, Sullivan WJ. TgIF2K-B Is an eIF2α Kinase in Toxoplasma gondii That Responds to Oxidative Stress and Optimizes Pathogenicity. Mbio. 12. PMID 33500345 DOI: 10.1128/mBio.03160-20 |
0.346 |
|
| 2020 |
Augusto L, Martynowicz J, Amin PH, Alakhras NS, Kaplan MH, Wek RC, Sullivan WJ. Toxoplasma gondii Co-opts the Unfolded Protein Response To Enhance Migration and Dissemination of Infected Host Cells. Mbio. 11. PMID 32636244 DOI: 10.1128/Mbio.00915-20 |
0.326 |
|
| 2019 |
Jiang J, Srivastava S, Seim G, Pavlova NN, King B, Zou L, Zhang C, Zhong M, Feng H, Kapur R, Wek RC, Fan J, Zhang J. Promoter demethylation of the asparagine synthetase gene is required for an ATF4-dependent adaptation to asparagine depletion. The Journal of Biological Chemistry. PMID 31659118 DOI: 10.1074/Jbc.Ra119.010447 |
0.459 |
|
| 2019 |
Staschke KA, Wek RC. Adapting to cell stress from inside and out. Nature Cell Biology. 21: 799-800. PMID 31263267 DOI: 10.1038/S41556-019-0354-X |
0.741 |
|
| 2019 |
Augusto L, Amin PH, Wek RC, Sullivan WJ. Regulation of arginine transport by GCN2 eIF2 kinase is important for replication of the intracellular parasite Toxoplasma gondii. Plos Pathogens. 15: e1007746. PMID 31194856 DOI: 10.1371/Journal.Ppat.1007746 |
0.454 |
|
| 2019 |
Miles R, Amin P, Misra J, Spandau D, Wek R. 962 Integrated stress response facilitates cutaneous wound healing Journal of Investigative Dermatology. 139: S166. DOI: 10.1016/J.Jid.2019.03.1038 |
0.381 |
|
| 2018 |
Augusto L, Martynowicz J, Staschke KA, Wek RC, Sullivan WJ. Effects of PERK eIF2α kinase inhibitor against . Antimicrobial Agents and Chemotherapy. PMID 30181373 DOI: 10.1128/Aac.01442-18 |
0.748 |
|
| 2018 |
Ogbechi J, Hall BS, Sbarrato T, Taunton J, Willis AE, Wek RC, Simmonds RE. Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4. Cell Death & Disease. 9: 397. PMID 29540678 DOI: 10.1038/S41419-018-0427-Y |
0.606 |
|
| 2018 |
Nikonorova IA, Mirek ET, Signore CC, Goudie MP, Wek RC, Anthony TG. -----------Time-resolved analysis of amino acid stress identifies eIF2 phosphorylation as necessary to inhibit mTORC1 activity in liver. The Journal of Biological Chemistry. PMID 29449374 DOI: 10.1074/Jbc.Ra117.001625 |
0.552 |
|
| 2018 |
Wek RC. Role of eIF2α Kinases in Translational Control and Adaptation to Cellular Stress. Cold Spring Harbor Perspectives in Biology. PMID 29440070 DOI: 10.1101/Cshperspect.A032870 |
0.623 |
|
| 2018 |
Spandau D, Collier A, Travers J, Wek R. 1140 Regulation of protein synthesis during the progression of UVB-induced squamous cell carcinogenesis Journal of Investigative Dermatology. 138: S194. DOI: 10.1016/J.Jid.2018.03.1154 |
0.417 |
|
| 2017 |
Zhang M, Gallego-Delgado J, Fernandez-Arias C, Waters NC, Rodriguez A, Tsuji M, Wek RC, Nussenzweig V, Sullivan WJ. Inhibiting the Plasmodium eIF2α Kinase PK4 Prevents Artemisinin-Induced Latency. Cell Host & Microbe. 22: 766-776.e4. PMID 29241041 DOI: 10.1016/J.Chom.2017.11.005 |
0.426 |
|
| 2017 |
Collier AE, Spandau DF, Wek RC. Translational control of a human CDKN1A mRNA splice variant regulates the fate of UVB-irradiated human keratinocytes. Molecular Biology of the Cell. PMID 29118075 DOI: 10.1091/Mbc.E17-06-0362 |
0.5 |
|
| 2017 |
Holmes MJ, Augusto LDS, Zhang M, Wek RC, Sullivan WJ. Translational Control in the Latency of Apicomplexan Parasites. Trends in Parasitology. PMID 28942109 DOI: 10.1016/J.Pt.2017.08.006 |
0.36 |
|
| 2017 |
Willy JA, Young SK, Mosley AL, Gawrieh S, Stevens JL, Masuoka HC, Wek RC. Function of Inhibitor of Brutons Tyrosine Kinase Isoform α (IBTKα) in Nonalcoholic Steatohepatitis links Autophagy and the Unfolded Protein Response. The Journal of Biological Chemistry. PMID 28710282 DOI: 10.1074/Jbc.M117.799304 |
0.467 |
|
| 2017 |
Collier AE, Wek RC, Spandau DF. Human keratinocyte differentiation requires translational control by the eIF2α kinase GCN2. The Journal of Investigative Dermatology. PMID 28528168 DOI: 10.1016/J.Jid.2017.04.029 |
0.554 |
|
| 2017 |
Al-Baghdadi RJT, Nikonorova IA, Mirek ET, Wang Y, Park J, Belden WJ, Wek RC, Anthony TG. Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase. Scientific Reports. 7: 1272. PMID 28455513 DOI: 10.1038/S41598-017-01041-7 |
0.481 |
|
| 2017 |
Pettit AP, Jonsson WO, Bargoud AR, Mirek ET, Peelor FF, Wang Y, Gettys TW, Kimball SR, Miller BF, Hamilton KL, Wek RC, Anthony TG. Dietary Methionine Restriction Regulates Liver Protein Synthesis and Gene Expression Independently of Eukaryotic Initiation Factor 2 Phosphorylation in Mice. The Journal of Nutrition. PMID 28446632 DOI: 10.3945/Jn.116.246710 |
0.418 |
|
| 2017 |
Nikonorova IA, Al-Baghdadi RJ, Mirek ET, Wang Y, Goudie MP, Wetstein BB, Dixon JL, Hine C, Mitchell JR, Adams CM, Wek RC, Anthony TG. Obesity Challenges the Hepatoprotective Function of the Integrated Stress Response to Asparaginase Exposure in Mice. The Journal of Biological Chemistry. PMID 28242759 DOI: 10.1074/Jbc.M116.768408 |
0.332 |
|
| 2016 |
Srivastava RK, Li C, Ahmad A, Abrams O, Gorbatyuk MS, Harrod KS, Wek RC, Afaq F, Athar M. ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis. Archives of Biochemistry and Biophysics. PMID 27638049 DOI: 10.1016/J.Abb.2016.09.003 |
0.364 |
|
| 2016 |
Young SK, Wek RC. Upstream open reading frames differentially regulate gene-specific translation in the Integrated Stress Response. The Journal of Biological Chemistry. PMID 27358398 DOI: 10.1074/Jbc.R116.733899 |
0.579 |
|
| 2016 |
Young SK, Shao Y, Bidwell JP, Wek RC. Nuclear Matrix Protein 4 is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response Via Repression of Gadd34 Expression. The Journal of Biological Chemistry. PMID 27129771 DOI: 10.1074/Jbc.M116.729830 |
0.542 |
|
| 2016 |
Young SK, Baird TD, Wek RC. Translation regulation of the glutamyl-prolyl-tRNA synthetase gene EPRS through bypass of uORFs with non-canonical initiation codons. The Journal of Biological Chemistry. PMID 27002157 DOI: 10.1074/Jbc.M116.722256 |
0.587 |
|
| 2016 |
Phillipson-Weiner L, Mirek ET, Wang Y, McAuliffe WG, Wek RC, Anthony TG. General control nonderepressible kinase 2 (GCN2) deletion predisposes to asparaginase-associated pancreatitis in mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. ajpgi.00052.2016. PMID 26968207 DOI: 10.1152/Ajpgi.00052.2016 |
0.455 |
|
| 2016 |
Fusakio ME, Willy JA, Wang Y, Mirek ET, Baghdadi RJ, Adams CM, Anthony TG, Wek RC. Transcription factor ATF4 directs basal and select induced gene expression in the unfolded protein response and cholesterol metabolism in liver. Molecular Biology of the Cell. PMID 26960794 DOI: 10.1091/Mbc.E16-01-0039 |
0.565 |
|
| 2016 |
Young SK, Palam LR, Wu C, Sachs MS, Wek RC. Ribosome Elongation Stall Directs Gene-Specific Translation In the Integrated Stress Response. The Journal of Biological Chemistry. PMID 26817837 DOI: 10.1074/Jbc.M115.705640 |
0.832 |
|
| 2016 |
Collier A, Wek R, Spandau D. 576 Translational control through eIF2α is required for cell cycle arrest following UVB irradiation Journal of Investigative Dermatology. 136: S102. DOI: 10.1016/J.Jid.2016.02.615 |
0.331 |
|
| 2016 |
Spandau D, Collier A, Wek R. 355 Preferential protein translation is required for keratinocyte differentiation Journal of Investigative Dermatology. 136: S62. DOI: 10.1016/J.Jid.2016.02.387 |
0.384 |
|
| 2015 |
Young SK, Willy JA, Wu C, Sachs MS, Wek RC. Ribosome Reinitiation Directs Gene-Specific Translation and Regulates the Integrated Stress Response. The Journal of Biological Chemistry. PMID 26446796 DOI: 10.1074/Jbc.M115.693184 |
0.581 |
|
| 2015 |
Collier AE, Wek RC, Spandau DF. Translational Repression Protects Human Keratinocytes from UVB-Induced Apoptosis through a Discordant eIF2 Kinase Stress Response. The Journal of Investigative Dermatology. 135: 2502-11. PMID 25950825 DOI: 10.1038/Jid.2015.177 |
0.619 |
|
| 2015 |
Willy JA, Young SK, Stevens JL, Masuoka HC, Wek RC. CHOP links endoplasmic reticulum stress to NF-κB activation in the pathogenesis of nonalcoholic steatohepatitis. Molecular Biology of the Cell. 26: 2190-204. PMID 25904325 DOI: 10.1091/Mbc.E15-01-0036 |
0.415 |
|
| 2015 |
Wilson GJ, Lennox BA, She P, Mirek ET, Al Baghdadi RJ, Fusakio ME, Dixon JL, Henderson GC, Wek RC, Anthony TG. GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment. American Journal of Physiology. Endocrinology and Metabolism. 308: E283-93. PMID 25491724 DOI: 10.1152/Ajpendo.00361.2014 |
0.371 |
|
| 2015 |
Gao R, Chen S, Kobayashi M, Yu H, Zhang Y, Wan Y, Young SK, Soltis A, Yu M, Vemula S, Fraenkel E, Cantor A, Antipin Y, Xu Y, Yoder MC, ... Wek RC, et al. Bmi1 promotes erythroid development through regulating ribosome biogenesis. Stem Cells (Dayton, Ohio). 33: 925-38. PMID 25385494 DOI: 10.1002/Stem.1896 |
0.411 |
|
| 2015 |
Collier AE, Wek RC, F Spandau D. Translational Repression Protects Human Keratinocytes from UVB-Induced Apoptosis through a Discordant eIF2 Kinase Stress Response Journal of Investigative Dermatology. DOI: 10.1038/jid.2015.177 |
0.43 |
|
| 2014 |
He H, Singh I, Wek SA, Dey S, Baird TD, Wek RC, Georgiadis MM. Crystal structures of GCN2 protein kinase C-terminal domains suggest regulatory differences in yeast and mammals. The Journal of Biological Chemistry. 289: 15023-34. PMID 24719324 DOI: 10.1074/Jbc.M114.560789 |
0.76 |
|
| 2014 |
Baird TD, Palam LR, Fusakio ME, Willy JA, Davis CM, McClintick JN, Anthony TG, Wek RC. Selective mRNA translation during eIF2 phosphorylation induces expression of IBTKα. Molecular Biology of the Cell. 25: 1686-97. PMID 24648495 DOI: 10.1091/Mbc.E14-02-0704 |
0.829 |
|
| 2014 |
Cambiaghi TD, Pereira CM, Shanmugam R, Bolech M, Wek RC, Sattlegger E, Castilho BA. Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2. Biochemical and Biophysical Research Communications. 443: 592-7. PMID 24333428 DOI: 10.1016/J.Bbrc.2013.12.021 |
0.629 |
|
| 2014 |
Konrad C, Wek RC, Sullivan WJ. GCN2-like eIF2α kinase manages the amino acid starvation response in Toxoplasma gondii. International Journal For Parasitology. 44: 139-46. PMID 24126185 DOI: 10.1016/J.Ijpara.2013.08.005 |
0.42 |
|
| 2014 |
Singh I, He H, Wek S, Dey S, Baird T, Wek R, Georgiadis M. Crystal structures of GCN2 C-terminal domain: Insight into GCN2 regulation Acta Crystallographica Section a Foundations and Advances. 70: C1407-C1407. DOI: 10.1107/S2053273314085921 |
0.726 |
|
| 2013 |
She P, Bunpo P, Cundiff JK, Wek RC, Harris RA, Anthony TG. General control nonderepressible 2 (GCN2) kinase protects oligodendrocytes and white matter during branched-chain amino acid deficiency in mice. The Journal of Biological Chemistry. 288: 31250-60. PMID 24019515 DOI: 10.1074/Jbc.M113.498469 |
0.42 |
|
| 2013 |
Wilson GJ, Bunpo P, Cundiff JK, Wek RC, Anthony TG. The eukaryotic initiation factor 2 kinase GCN2 protects against hepatotoxicity during asparaginase treatment. American Journal of Physiology. Endocrinology and Metabolism. 305: E1124-33. PMID 24002574 DOI: 10.1152/Ajpendo.00080.2013 |
0.508 |
|
| 2013 |
Teske BF, Fusakio ME, Zhou D, Shan J, McClintick JN, Kilberg MS, Wek RC. CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis. Molecular Biology of the Cell. 24: 2477-90. PMID 23761072 DOI: 10.1091/Mbc.E13-01-0067 |
0.84 |
|
| 2013 |
Joyce BR, Tampaki Z, Kim K, Wek RC, Sullivan WJ. The unfolded protein response in the protozoan parasite Toxoplasma gondii features translational and transcriptional control. Eukaryotic Cell. 12: 979-89. PMID 23666622 DOI: 10.1128/Ec.00021-13 |
0.598 |
|
| 2013 |
Babcock JT, Nguyen HB, He Y, Hendricks JW, Wek RC, Quilliam LA. Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response. The Journal of Biological Chemistry. 288: 15687-98. PMID 23612979 DOI: 10.1074/Jbc.M112.431056 |
0.473 |
|
| 2013 |
Konrad C, Queener SF, Wek RC, Sullivan WJ. Inhibitors of eIF2α dephosphorylation slow replication and stabilize latency in Toxoplasma gondii. Antimicrobial Agents and Chemotherapy. 57: 1815-22. PMID 23380722 DOI: 10.1128/Aac.01899-12 |
0.359 |
|
| 2012 |
Anthony TG, Wek RC. TXNIP switches tracks toward a terminal UPR. Cell Metabolism. 16: 135-7. PMID 22883225 DOI: 10.1016/J.Cmet.2012.07.012 |
0.361 |
|
| 2012 |
Trinh MA, Kaphzan H, Wek RC, Pierre P, Cavener DR, Klann E. Brain-specific disruption of the eIF2α kinase PERK decreases ATF4 expression and impairs behavioral flexibility. Cell Reports. 1: 676-88. PMID 22813743 DOI: 10.1016/J.Celrep.2012.04.010 |
0.376 |
|
| 2012 |
Baird TD, Wek RC. Eukaryotic initiation factor 2 phosphorylation and translational control in metabolism. Advances in Nutrition (Bethesda, Md.). 3: 307-21. PMID 22585904 DOI: 10.3945/An.112.002113 |
0.631 |
|
| 2012 |
Dey S, Savant S, Teske BF, Hatzoglou M, Calkhoven CF, Wek RC. Transcriptional repression of ATF4 gene by CCAAT/enhancer-binding protein β (C/EBPβ) differentially regulates integrated stress response. The Journal of Biological Chemistry. 287: 21936-49. PMID 22556424 DOI: 10.1074/Jbc.M112.351783 |
0.835 |
|
| 2012 |
Dai MS, Challagundla KB, Sun XX, Palam LR, Zeng SX, Wek RC, Lu H. Physical and functional interaction between ribosomal protein L11 and the tumor suppressor ARF. The Journal of Biological Chemistry. 287: 17120-9. PMID 22467867 DOI: 10.1074/Jbc.M111.311902 |
0.733 |
|
| 2012 |
Babcock JT, Nguen HB, He Y, Wek RC, Quilliam LA. Abstract LB-247: mTORC1 enhances bortezomib-induced death in TSC-null cells by a c-MYC-dependent induction of the unfolded protein response Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Lb-247 |
0.407 |
|
| 2011 |
Teske BF, Wek SA, Bunpo P, Cundiff JK, McClintick JN, Anthony TG, Wek RC. The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress. Molecular Biology of the Cell. 22: 4390-405. PMID 21917591 DOI: 10.1091/Mbc.E11-06-0510 |
0.849 |
|
| 2011 |
Konrad C, Wek RC, Sullivan WJ. A GCN2-like eukaryotic initiation factor 2 kinase increases the viability of extracellular Toxoplasma gondii parasites. Eukaryotic Cell. 10: 1403-12. PMID 21908594 DOI: 10.1128/Ec.05117-11 |
0.407 |
|
| 2011 |
Singh CR, Watanabe R, Zhou D, Jennings MD, Fukao A, Lee B, Ikeda Y, Chiorini JA, Campbell SG, Ashe MP, Fujiwara T, Wek RC, Pavitt GD, Asano K. Mechanisms of translational regulation by a human eIF5-mimic protein. Nucleic Acids Research. 39: 8314-28. PMID 21745818 DOI: 10.1093/Nar/Gkr339 |
0.621 |
|
| 2011 |
Palam LR, Baird TD, Wek RC. Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation. The Journal of Biological Chemistry. 286: 10939-49. PMID 21285359 DOI: 10.1074/Jbc.M110.216093 |
0.839 |
|
| 2011 |
Teske BF, Baird TD, Wek RC. Methods for analyzing eIF2 kinases and translational control in the unfolded protein response. Methods in Enzymology. 490: 333-56. PMID 21266259 DOI: 10.1016/B978-0-12-385114-7.00019-2 |
0.854 |
|
| 2010 |
Nemoto N, Udagawa T, Ohira T, Jiang L, Hirota K, Wilkinson CR, Bähler J, Jones N, Ohta K, Wek RC, Asano K. The roles of stress-activated Sty1 and Gcn2 kinases and of the protooncoprotein homologue Int6/eIF3e in responses to endogenous oxidative stress during histidine starvation. Journal of Molecular Biology. 404: 183-201. PMID 20875427 DOI: 10.1016/J.Jmb.2010.09.016 |
0.601 |
|
| 2010 |
Bunpo P, Cundiff JK, Reinert RB, Wek RC, Aldrich CJ, Anthony TG. The eIF2 kinase GCN2 is essential for the murine immune system to adapt to amino acid deprivation by asparaginase. The Journal of Nutrition. 140: 2020-7. PMID 20861212 DOI: 10.3945/Jn.110.129197 |
0.412 |
|
| 2010 |
Joyce BR, Queener SF, Wek RC, Sullivan WJ. Phosphorylation of eukaryotic initiation factor-2{alpha} promotes the extracellular survival of obligate intracellular parasite Toxoplasma gondii. Proceedings of the National Academy of Sciences of the United States of America. 107: 17200-5. PMID 20855600 DOI: 10.1073/Pnas.1007610107 |
0.467 |
|
| 2010 |
Dey S, Baird TD, Zhou D, Palam LR, Spandau DF, Wek RC. Both transcriptional regulation and translational control of ATF4 are central to the integrated stress response. The Journal of Biological Chemistry. 285: 33165-74. PMID 20732869 DOI: 10.1074/Jbc.M110.167213 |
0.84 |
|
| 2010 |
Zaborske JM, Wu X, Wek RC, Pan T. Selective control of amino acid metabolism by the GCN2 eIF2 kinase pathway in Saccharomyces cerevisiae. Bmc Biochemistry. 11: 29. PMID 20684782 DOI: 10.1186/1471-2091-11-29 |
0.395 |
|
| 2010 |
Wek RC, Staschke KA. How do tumours adapt to nutrient stress? The Embo Journal. 29: 1946-7. PMID 20551969 DOI: 10.1038/Emboj.2010.110 |
0.73 |
|
| 2010 |
Wek RC, Anthony TG. Obesity: stressing about unfolded proteins. Nature Medicine. 16: 374-6. PMID 20376042 DOI: 10.1038/Nm0410-374 |
0.361 |
|
| 2010 |
Staschke KA, Dey S, Zaborske JM, Palam LR, McClintick JN, Pan T, Edenberg HJ, Wek RC. Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast. The Journal of Biological Chemistry. 285: 16893-911. PMID 20233714 DOI: 10.1074/Jbc.M110.121947 |
0.797 |
|
| 2010 |
Wek RC, Anthony TG. Erratum: Corrigendum: Obesity: stressing about unfolded proteins Nature Medicine. 16: 607-607. DOI: 10.1038/Nm0510-607B |
0.307 |
|
| 2009 |
Bunpo P, Dudley A, Cundiff JK, Cavener DR, Wek RC, Anthony TG. GCN2 protein kinase is required to activate amino acid deprivation responses in mice treated with the anti-cancer agent L-asparaginase. The Journal of Biological Chemistry. 284: 32742-9. PMID 19783659 DOI: 10.1074/Jbc.M109.047910 |
0.432 |
|
| 2009 |
Huang CC, Chiribau CB, Majumder M, Chiang CM, Wek RC, Kelm RJ, Khalili K, Snider MD, Hatzoglou M. A bifunctional intronic element regulates the expression of the arginine/lysine transporter Cat-1 via mechanisms involving the purine-rich element binding protein A (Pur alpha). The Journal of Biological Chemistry. 284: 32312-20. PMID 19720825 DOI: 10.1074/Jbc.M109.024471 |
0.514 |
|
| 2009 |
Wek RC, Anthony TG. Beta testing the antioxidant function of eIF2alpha phosphorylation in diabetes prevention. Cell Metabolism. 10: 1-2. PMID 19583945 DOI: 10.1016/J.Cmet.2009.06.005 |
0.33 |
|
| 2009 |
Zaborske JM, Narasimhan J, Jiang L, Wek SA, Dittmar KA, Freimoser F, Pan T, Wek RC. Genome-wide analysis of tRNA charging and activation of the eIF2 kinase Gcn2p. The Journal of Biological Chemistry. 284: 25254-67. PMID 19546227 DOI: 10.1074/Jbc.M109.000877 |
0.425 |
|
| 2009 |
Butler JS, Palam LR, Tate CM, Sanford JR, Wek RC, Skalnik DG. DNA Methyltransferase protein synthesis is reduced in CXXC finger protein 1-deficient embryonic stem cells. Dna and Cell Biology. 28: 223-31. PMID 19388845 DOI: 10.1089/Dna.2009.0854 |
0.755 |
|
| 2008 |
Vonlaufen N, Kanzok SM, Wek RC, Sullivan WJ. Stress response pathways in protozoan parasites. Cellular Microbiology. 10: 2387-99. PMID 18647172 DOI: 10.1111/J.1462-5822.2008.01210.X |
0.402 |
|
| 2008 |
Udagawa T, Nemoto N, Wilkinson CR, Narashimhan J, Jiang L, Watt S, Zook A, Jones N, Wek RC, Bähler J, Asano K. Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeast. The Journal of Biological Chemistry. 283: 22063-75. PMID 18502752 DOI: 10.1074/Jbc.M710017200 |
0.628 |
|
| 2008 |
Narasimhan J, Joyce BR, Naguleswaran A, Smith AT, Livingston MR, Dixon SE, Coppens I, Wek RC, Sullivan WJ. Translation regulation by eukaryotic initiation factor-2 kinases in the development of latent cysts in Toxoplasma gondii. The Journal of Biological Chemistry. 283: 16591-601. PMID 18420584 DOI: 10.1074/Jbc.M800681200 |
0.61 |
|
| 2008 |
Neznanov N, Dragunsky EM, Chumakov KM, Neznanova L, Wek RC, Gudkov AV, Banerjee AK. Different effect of proteasome inhibition on vesicular stomatitis virus and poliovirus replication. Plos One. 3: e1887. PMID 18382670 DOI: 10.1371/Journal.Pone.0001887 |
0.457 |
|
| 2008 |
Liang F, Luo Y, Dong Y, Walls CD, Liang J, Jiang HY, Sanford JR, Wek RC, Zhang ZY. Translational control of C-terminal Src kinase (Csk) expression by PRL3 phosphatase. The Journal of Biological Chemistry. 283: 10339-46. PMID 18268019 DOI: 10.1074/Jbc.M708285200 |
0.567 |
|
| 2008 |
Zhou D, Palam LR, Jiang L, Narasimhan J, Staschke KA, Wek RC. Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions. The Journal of Biological Chemistry. 283: 7064-73. PMID 18195013 DOI: 10.1074/Jbc.M708530200 |
0.845 |
|
| 2008 |
Gass JN, Jiang HY, Wek RC, Brewer JW. The unfolded protein response of B-lymphocytes: PERK-independent development of antibody-secreting cells. Molecular Immunology. 45: 1035-43. PMID 17822768 DOI: 10.1016/J.Molimm.2007.07.029 |
0.421 |
|
| 2007 |
Wek RC, Cavener DR. Translational control and the unfolded protein response. Antioxidants & Redox Signaling. 9: 2357-71. PMID 17760508 DOI: 10.1089/Ars.2007.1764 |
0.611 |
|
| 2007 |
Jiang HY, Jiang L, Wek RC. The eukaryotic initiation factor-2 kinase pathway facilitates differential GADD45a expression in response to environmental stress. The Journal of Biological Chemistry. 282: 3755-65. PMID 17170114 DOI: 10.1074/Jbc.M606461200 |
0.644 |
|
| 2007 |
Lopez AB, Wang C, Huang CC, Yaman I, Li Y, Chakravarty K, Johnson PF, Chiang CM, Snider MD, Wek RC, Hatzoglou M. A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation. The Biochemical Journal. 402: 163-73. PMID 17042743 DOI: 10.1042/Bj20060941 |
0.559 |
|
| 2006 |
Wek RC, Anthony TG. EXtENDINg beta cell survival by UPRegulating ATF4 translation. Cell Metabolism. 4: 333-4. PMID 17084705 DOI: 10.1016/J.Cmet.2006.10.006 |
0.489 |
|
| 2006 |
Reinert RB, Oberle LM, Wek SA, Bunpo P, Wang XP, Mileva I, Goodwin LO, Aldrich CJ, Durden DL, McNurlan MA, Wek RC, Anthony TG. Role of glutamine depletion in directing tissue-specific nutrient stress responses to L-asparaginase. The Journal of Biological Chemistry. 281: 31222-33. PMID 16931516 DOI: 10.1074/Jbc.M604511200 |
0.512 |
|
| 2006 |
Joshi MA, Jeoung NH, Obayashi M, Hattab EM, Brocken EG, Liechty EA, Kubek MJ, Vattem KM, Wek RC, Harris RA. Impaired growth and neurological abnormalities in branched-chain alpha-keto acid dehydrogenase kinase-deficient mice. The Biochemical Journal. 400: 153-62. PMID 16875466 DOI: 10.1042/Bj20060869 |
0.369 |
|
| 2006 |
Carnevalli LS, Pereira CM, Jaqueta CB, Alves VS, Paiva VN, Vattem KM, Wek RC, Mello LE, Castilho BA. Phosphorylation of the alpha subunit of translation initiation factor-2 by PKR mediates protein synthesis inhibition in the mouse brain during status epilepticus. The Biochemical Journal. 397: 187-94. PMID 16492139 DOI: 10.1042/Bj20051643 |
0.494 |
|
| 2006 |
Wek RC, Jiang HY, Anthony TG. Coping with stress: EIF2 kinases and translational control Biochemical Society Transactions. 34: 7-11. PMID 16246168 DOI: 10.1042/Bst0340007 |
0.631 |
|
| 2005 |
Dunand-Sauthier I, Walker CA, Narasimhan J, Pearce AK, Wek RC, Humphrey TC. Stress-activated protein kinase pathway functions to support protein synthesis and translational adaptation in response to environmental stress in fission yeast. Eukaryotic Cell. 4: 1785-93. PMID 16278445 DOI: 10.1128/Ec.4.11.1785-1793.2005 |
0.631 |
|
| 2005 |
Pereira CM, Sattlegger E, Jiang HY, Longo BM, Jaqueta CB, Hinnebusch AG, Wek RC, Mello LEAM, Castilho BA. IMPACT, a protein preferentially expressed in the mouse brain, binds GCN1 and inhibits GCN2 activation Journal of Biological Chemistry. 280: 28316-28323. PMID 15937339 DOI: 10.1074/Jbc.M408571200 |
0.497 |
|
| 2005 |
Hao S, Sharp JW, Ross-Inta CM, McDaniel BJ, Anthony TG, Wek RC, Cavener DR, McGrath BC, Rudell JB, Koehnle TJ, Gietzen DW. Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex. Science (New York, N.Y.). 307: 1776-8. PMID 15774759 DOI: 10.1126/Science.1104882 |
0.414 |
|
| 2005 |
Jiang HY, Wek RC. Phosphorylation of the alpha-subunit of the eukaryotic initiation factor-2 (eIF2alpha) reduces protein synthesis and enhances apoptosis in response to proteasome inhibition. The Journal of Biological Chemistry. 280: 14189-202. PMID 15684420 DOI: 10.1074/Jbc.M413660200 |
0.603 |
|
| 2005 |
Jiang HY, Wek RC. GCN2 phosphorylation of eIF2alpha activates NF-kappaB in response to UV irradiation. The Biochemical Journal. 385: 371-80. PMID 15355306 DOI: 10.1042/Bj20041164 |
0.537 |
|
| 2004 |
Zhan K, Narasimhan J, Wek RC. Differential activation of eIF2 kinases in response to cellular stresses in Schizosaccharomyces pombe. Genetics. 168: 1867-75. PMID 15611163 DOI: 10.1534/Genetics.104.031443 |
0.71 |
|
| 2004 |
Vattem KM, Wek RC. Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 11269-74. PMID 15277680 DOI: 10.1073/Pnas.0400541101 |
0.58 |
|
| 2004 |
Senée V, Vattem KM, Delépine M, Rainbow LA, Haton C, Lecoq A, Shaw NJ, Robert JJ, Rooman R, Diatloff-Zito C, Michaud JL, Bin-Abbas B, Taha D, Zabel B, Franceschini P, ... ... Wek RC, et al. Wolcott-Rallison Syndrome: clinical, genetic, and functional study of EIF2AK3 mutations and suggestion of genetic heterogeneity. Diabetes. 53: 1876-83. PMID 15220213 DOI: 10.2337/Diabetes.53.7.1876 |
0.312 |
|
| 2004 |
Narasimhan J, Staschke KA, Wek RC. Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions. The Journal of Biological Chemistry. 279: 22820-32. PMID 15010461 DOI: 10.1074/Jbc.M402228200 |
0.784 |
|
| 2004 |
Sullivan WJ, Narasimhan J, Bhatti MM, Wek RC. Parasite-specific eIF2 (eukaryotic initiation factor-2) kinase required for stress-induced translation control. The Biochemical Journal. 380: 523-31. PMID 14989696 DOI: 10.1042/Bj20040262 |
0.574 |
|
| 2004 |
Jiang HY, Wek SA, McGrath BC, Lu D, Hai T, Harding HP, Wang X, Ron D, Cavener DR, Wek RC. Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Molecular and Cellular Biology. 24: 1365-77. PMID 14729979 DOI: 10.1128/Mcb.24.3.1365-1377.2004 |
0.651 |
|
| 2003 |
Abe T, Lu X, Jiang Y, Boccone CE, Qian S, Vattem KM, Wek RC, Walsh JP. Site-directed mutagenesis of the active site of diacylglycerol kinase alpha: calcium and phosphatidylserine stimulate enzyme activity via distinct mechanisms. The Biochemical Journal. 375: 673-80. PMID 12908872 DOI: 10.1042/Bj20031052 |
0.376 |
|
| 2003 |
Jiang HY, Wek SA, McGrath BC, Scheuner D, Kaufman RJ, Cavener DR, Wek RC. Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses. Molecular and Cellular Biology. 23: 5651-63. PMID 12897138 DOI: 10.1128/Mcb.23.16.5651-5663.2003 |
0.552 |
|
| 2002 |
Zhan K, Vattem KM, Bauer BN, Dever TE, Chen JJ, Wek RC. Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for resistance to environmental stresses Molecular and Cellular Biology. 22: 7134-7146. PMID 12242291 DOI: 10.1128/Mcb.22.20.7134-7146.2002 |
0.707 |
|
| 2002 |
Zhang P, McGrath BC, Reinert J, Olsen DS, Lei L, Gill S, Wek SA, Vattem KM, Wek RC, Kimball SR, Jefferson LS, Cavener DR. The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice. Molecular and Cellular Biology. 22: 6681-8. PMID 12215525 DOI: 10.1128/Mcb.22.19.6681-6688.2002 |
0.351 |
|
| 2002 |
Ma K, Vattem KM, Wek RC. Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress. The Journal of Biological Chemistry. 277: 18728-35. PMID 11907036 DOI: 10.1074/Jbc.M200903200 |
0.673 |
|
| 2002 |
Fernandez J, Yaman I, Merrick WC, Koromilas A, Wek RC, Sood R, Hensold J, Hatzoglou M. Regulation of internal ribosome entry site-mediated translation by eukaryotic initiation factor-2α phosphorylation and translation of a small upstream open reading frame Journal of Biological Chemistry. 277: 2050-2058. PMID 11684693 DOI: 10.1074/Jbc.M109199200 |
0.662 |
|
| 2001 |
Vattem KM, Staschke KA, Wek RC. Mechanism of activation of the double-stranded-RNA-dependent protein kinase, PKR: role of dimerization and cellular localization in the stimulation of PKR phosphorylation of eukaryotic initiation factor-2 (eIF2). European Journal of Biochemistry / Febs. 268: 3674-84. PMID 11432733 DOI: 10.1046/J.1432-1327.2001.02273.X |
0.752 |
|
| 2001 |
Vattem KM, Staschke KA, Zhu S, Wek RC. Inhibitory sequences in the N-terminus of the double-stranded-RNA-dependent protein kinase, PKR, are important for regulating phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha). European Journal of Biochemistry / Febs. 268: 1143-53. PMID 11179981 DOI: 10.1046/J.1432-1327.2001.01979.X |
0.749 |
|
| 2001 |
Kimball SR, Clemens MJ, Tilleray VJ, Wek RC, Horetsky RL, Jefferson LS. The double-stranded RNA-activated protein kinase PKR is dispensable for regulation of translation initiation in response to either calcium mobilization from the endoplasmic reticulum or essential amino acid starvation Biochemical and Biophysical Research Communications. 280: 293-300. PMID 11162513 DOI: 10.1006/Bbrc.2000.4103 |
0.561 |
|
| 2000 |
Harding HP, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M, Ron D. Regulated translation initiation controls stress-induced gene expression in mammalian cells. Molecular Cell. 6: 1099-108. PMID 11106749 DOI: 10.1016/S1097-2765(00)00108-8 |
0.644 |
|
| 2000 |
Yang R, Wek SA, Wek RC. Glucose limitation induces GCN4 translation by activation of Gcn2 protein kinase. Molecular and Cellular Biology. 20: 2706-17. PMID 10733573 DOI: 10.1128/Mcb.20.8.2706-2717.2000 |
0.688 |
|
| 2000 |
Sood R, Porter AC, Ma K, Quilliam LA, Wek RC. Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress. The Biochemical Journal. 346: 281-93. PMID 10677345 DOI: 10.1042/0264-6021:3460281 |
0.764 |
|
| 2000 |
Sood R, Porter AC, Olsen DA, Cavener DR, Wek RC. A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha. Genetics. 154: 787-801. PMID 10655230 |
0.646 |
|
| 1998 |
Shi Y, Vattem KM, Sood R, An J, Liang J, Stramm L, Wek RC. Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. Molecular and Cellular Biology. 18: 7499-509. PMID 9819435 DOI: 10.1128/Mcb.18.12.7499 |
0.66 |
|
| 1998 |
Yang R, Chun KT, Wek RC. Mitochondrial respiratory mutants in yeast inhibit glycogen accumulation by blocking activation of glycogen synthase. The Journal of Biological Chemistry. 273: 31337-44. PMID 9813042 DOI: 10.1074/Jbc.273.47.31337 |
0.653 |
|
| 1998 |
Olsen DS, Jordan B, Chen D, Wek RC, Cavener DR. Isolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2alpha kinase. Genetics. 149: 1495-509. PMID 9649537 |
0.365 |
|
| 1998 |
Zhu S, Wek RC. Ribosome-binding domain of eukaryotic initiation factor-2 kinase GCN2 facilitates translation control Journal of Biological Chemistry. 273: 1808-1814. PMID 9430731 DOI: 10.1074/Jbc.273.3.1808 |
0.51 |
|
| 1997 |
Zhu S, Romano PR, Wek RC. Ribosome targeting of PKR is mediated by two double-stranded RNA- binding domains and facilitates in vivo phosphorylation of eukaryotic initiation factor-2 Journal of Biological Chemistry. 272: 14434-14441. PMID 9162083 DOI: 10.1074/Jbc.272.22.14434 |
0.44 |
|
| 1997 |
Sood R, Wek RC. GCN2, an eIF-2a protein kinase containing sequences related to aminoacyl-trna synthetases, is conserved from yeast to mammals Faseb Journal. 11. |
0.429 |
|
| 1996 |
Zhu S, Sobolev AY, Wek RC. Histidyl-tRNA synthetase-related sequences in GCN2 protein kinase regulate in vitro phosphorylation of eIF-2 Journal of Biological Chemistry. 271: 24989-24994. PMID 8798780 DOI: 10.1074/Jbc.271.40.24989 |
0.469 |
|
| 1996 |
Qian W, Zhu S, Sobolev AY, Wek RC. Expression of vaccinia virus K3L protein in yeast inhibits eukaryotic initiation factor-2 kinase GCN2 and the general amino acid control pathway Journal of Biological Chemistry. 271: 13202-13207. PMID 8662715 DOI: 10.1074/Jbc.271.22.13202 |
0.484 |
|
| 1996 |
Zhu S, Sobolov A, Wek RC. Ribosome targeting of eIF-2 protein kinases, GCN2 and PKR Faseb Journal. 10: A1267. |
0.396 |
|
| 1995 |
Wek SA, Zhu S, Wek RC. The histidyl-tRNA synthetase-related sequence in the eIF-2α protein kinase GCN2 interacts with tRNA and is required for activation in response to starvation for different amino acids Molecular and Cellular Biology. 15: 4497-4506. PMID 7623840 DOI: 10.1128/Mcb.15.8.4497 |
0.495 |
|
| 1994 |
Vazquez De Aldana CR, Wek RC, San Segundo P, Truesdell AG, Hinnebusch AG. Multicopy tRNA genes functionally suppress mutations in yeast eIF-2α kinase GCN2: Evidence for separate pathways coupling GCN4 expression to uncharged tRNA Molecular and Cellular Biology. 14: 7920-7932. PMID 7969132 |
0.372 |
|
| 1994 |
Wek RC. elF-2 kinases: regulators of general and gene-specific translation initiation Trends in Biochemical Sciences. 19: 491-496. PMID 7855893 DOI: 10.1016/0968-0004(94)90136-8 |
0.479 |
|
| 1992 |
Dever TE, Feng L, Wek RC, Cigan AM, Donahue TF, Hinnebusch AG. Phosphorylation of initiation factor 2α by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast Cell. 68: 585-596. PMID 1739968 DOI: 10.1016/0092-8674(92)90193-G |
0.443 |
|
| 1992 |
Ramirez M, Wek RC, Vazquez De Aldana CR, Jackson BM, Freeman B, Hinnebusch AG. Mutations activating the yeast eIF-2α kinase GCN2: Isolation of alleles altering the domain related to histidyl-tRNA synthetases Molecular and Cellular Biology. 12: 5801-5815. PMID 1448107 |
0.383 |
|
| 1992 |
Wek RC, Cannon JF, Dever TE, Hinnebusch AG. Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2α kinase GCN2 Molecular and Cellular Biology. 12: 5700-5710. PMID 1333044 DOI: 10.1128/Mcb.12.12.5700 |
0.519 |
|
| 1991 |
Ramirez M, Wek RC, Hinnebusch AG. Ribosome Association of GCN2 Protein Kinase, a Translational Activator of the GCN4 Gene of Saccharomyces cerevisiae Molecular and Cellular Biology. 11: 3027-3036. PMID 2038314 DOI: 10.1128/Mcb.11.6.3027 |
0.486 |
|
| 1990 |
Hannig EM, Williams NP, Wek RC, Hinnebusch AG. The translational activator GCN3 functions downstream from GCN1 and GCN2 in the regulatory pathway that couples GCN4 expression to amino acid availability in Saccharomyces cerevisiae. Genetics. 126: 549-62. PMID 2249755 |
0.324 |
|
| 1990 |
Wek RC, Ramirez M, Jackson BM, Hinnebusch AG. Identification of Positive-Acting Domains in GCN2 Protein Kinase Required for Translational Activation of GCN4 Expression Molecular and Cellular Biology. 10: 2820-2831. PMID 2188100 DOI: 10.1128/Mcb.10.6.2820 |
0.507 |
|
| 1989 |
Wek RC, Jackson BM, Hinnebusch AG. Juxtaposition of domains homologous to protein kinase and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability Proceedings of the National Academy of Sciences of the United States of America. 86: 4579-4583. PMID 2660141 DOI: 10.1073/Pnas.86.12.4579 |
0.473 |
|
| 1986 |
Wek RC, Hatfield GW. Examination of the internal promoter, PE, in the ilvGMEDA operon of E. coli K-12. Nucleic Acids Research. 14: 2763-77. PMID 2421252 DOI: 10.1093/Nar/14.6.2763 |
0.396 |
|
| 1985 |
Wek RC, Hauser CA, Hatfield GW. The nucleotide sequence of the ilvBN operon of Escherichia coli: Sequence homologies of the acetohydroxy acid synthase isozymes Nucleic Acids Research. 13: 3995-4010. PMID 2989782 DOI: 10.1093/Nar/13.11.3995 |
0.331 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 2019 |
Shao Y, Wichern E, Childress PJ, Adaway M, Misra J, Klunk A, Burr DB, Wek RC, Mosley AL, Liu Y, Robling AG, Brustovetsky N, Hamilton J, Jacobs K, Vashishth D, et al. Loss of Nmp4 optimizes osteogenic metabolism and secretion to enhance bone quality. American Journal of Physiology. Endocrinology and Metabolism. PMID 30645175 DOI: 10.1152/Ajpendo.00343.2018 |
0.297 |
|
| 1988 |
Wek RC, Hatfield GW. Transcriptional activation at adjacent operators in the divergent-overlapping ilvY and ilvC promoters of Escherichia coli. Journal of Molecular Biology. 203: 643-63. PMID 3062177 DOI: 10.1016/0022-2836(88)90199-4 |
0.296 |
|
| 2021 |
Ebert SM, Rasmussen BB, Judge AR, Judge SM, Larsson L, Wek RC, Anthony TG, Marcotte GR, Miller MJ, Yorek MA, Vella A, Volpi E, Stern JI, Strub MD, Ryan Z, et al. Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy. The Journal of Nutrition. PMID 34958390 DOI: 10.1093/jn/nxab440 |
0.29 |
|
| 2023 |
Ebert SM, Rasmussen BB, Judge AR, Judge SM, Larsson L, Wek RC, Anthony TG, Marcotte GR, Miller MJ, Yorek MA, Vella A, Volpi E, Stern JI, Strub MD, Ryan Z, et al. Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy. The Journal of Nutrition. 152: 926-938. PMID 36967183 DOI: 10.1093/jn/nxab440 |
0.29 |
|
| 2022 |
Jonsson WO, Mirek ET, Wek RC, Anthony TG. Activation and execution of the hepatic integrated stress response by dietary essential amino acid deprivation is amino acid specific. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 36: e22396. PMID 35690926 DOI: 10.1096/fj.202200204RR |
0.287 |
|
| 2015 |
Benmerzouga I, Checkley LA, Ferdig MT, Arrizabalaga G, Wek RC, Sullivan WJ. Guanabenz repurposed as an antiparasitic with activity against acute and latent toxoplasmosis. Antimicrobial Agents and Chemotherapy. 59: 6939-45. PMID 26303803 DOI: 10.1128/Aac.01683-15 |
0.284 |
|
| 1987 |
Wek RC, Sameshima JH, Hatfield GW. Rho-dependent transcriptional polarity in the ilvGMEDA operon of wild-type Escherichia coli K12. The Journal of Biological Chemistry. 262: 15256-61. PMID 2822718 |
0.271 |
|
| 2004 |
Anthony TG, McDaniel BJ, Byerley RL, McGrath BC, Cavener DR, McNurlan MA, Wek RC. Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2. The Journal of Biological Chemistry. 279: 36553-61. PMID 15213227 DOI: 10.1074/jbc.M404559200 |
0.269 |
|
| 1986 |
Wek RC, Hatfield GW. Nucleotide sequence and in vivo expression of the ilvY and ilvC genes in Escherichia coli K12. Transcription from divergent overlapping promoters. The Journal of Biological Chemistry. 261: 2441-50. PMID 3003115 |
0.268 |
|
| 1989 |
Sameshima JH, Wek RC, Hatfield GW. Overlapping transcription and termination of the convergent ilvA and ilvY genes of Escherichia coli. The Journal of Biological Chemistry. 264: 1224-31. PMID 2642900 |
0.261 |
|
| 2021 |
Jonsson WO, Margolies NS, Mirek ET, Zhang Q, Linden MA, Hill CM, Link C, Bithi N, Zalma B, Levy JL, Pettit AP, Miller JW, Hine C, Morrison CD, Gettys TW, ... ... Wek RC, et al. Physiologic Responses to Dietary Sulfur Amino Acid Restriction in Mice Are Influenced by Atf4 Status and Biological Sex. The Journal of Nutrition. PMID 33512502 DOI: 10.1093/jn/nxaa396 |
0.25 |
|
| 2011 |
Joyce BR, Konrad C, Wek RC, Sullivan WJ. Translation control is critical during acute and chronic stages of toxoplasmosis infection. Expert Review of Anti-Infective Therapy. 9: 1-3. PMID 21171869 DOI: 10.1586/Eri.10.146 |
0.248 |
|
| 2019 |
Martynowicz J, Augusto L, Wek RC, Boehm SL, Sullivan WJ. Guanabenz Reverses a Key Behavioral Change Caused by Latent Toxoplasmosis in Mice by Reducing Neuroinflammation. Mbio. 10. PMID 31040237 DOI: 10.1128/Mbio.00381-19 |
0.247 |
|
| 2008 |
Chambers KT, Unverferth JA, Weber SM, Wek RC, Urano F, Corbett JA. The role of nitric oxide and the unfolded protein response in cytokine-induced beta-cell death. Diabetes. 57: 124-32. PMID 17928398 DOI: 10.2337/db07-0944 |
0.247 |
|
| 2019 |
Holmes MJ, Shah P, Wek RC, Sullivan WJ. Simultaneous Ribosome Profiling of Human Host Cells Infected with Toxoplasma gondii. Msphere. 4. PMID 31167946 DOI: 10.1128/mSphere.00292-19 |
0.241 |
|
| 2023 |
Korff C, Atkinson E, Adaway M, Klunk A, Wek RC, Vashishth D, Wallace JM, Anderson-Baucum EK, Evans-Molina C, Robling AG, Bidwell JP. NMP4, an Arbiter of Bone Cell Secretory Capacity and Regulator of Skeletal Response to PTH Therapy. Calcified Tissue International. PMID 37147466 DOI: 10.1007/s00223-023-01088-x |
0.238 |
|
| 2023 |
Koppes EA, Johnson MA, Moresco JJ, Luppi P, Lewis DW, Stolz DB, Diedrich JK, Yates JR, Wek RC, Watkins SC, Gollin SM, Park HJ, Drain P, Nicholls RD. Insulin secretion deficits in a Prader-Willi syndrome β-cell model are associated with a concerted downregulation of multiple endoplasmic reticulum chaperones. Plos Genetics. 19: e1010710. PMID 37068109 DOI: 10.1371/journal.pgen.1010710 |
0.237 |
|
| 2017 |
Shao Y, Hernandez-Buquer S, Childress P, Stayrook KR, Alvarez MB, Davis H, Plotkin L, He Y, Condon KW, Burr DB, Warden SJ, Robling AG, Yang FC, Wek RC, Allen MR, et al. Improving Combination Osteoporosis Therapy In a Preclinical Model of Heightened Osteoanabolism. Endocrinology. PMID 28637206 DOI: 10.1210/En.2017-00355 |
0.237 |
|
| 2022 |
Chen Q, Bates AM, Hanquier JN, Simpson E, Rusch DB, Podicheti R, Liu Y, Wek RC, Cornett EM, Georgiadis MM. Structural and genome-wide analyses suggest that transposon-derived protein SETMAR alters transcription and splicing. The Journal of Biological Chemistry. 298: 101894. PMID 35378129 DOI: 10.1016/j.jbc.2022.101894 |
0.235 |
|
| 1988 |
Lawther RP, Wek RC, Lopes JM, Pereira R, Taillon BE, Hatfield GW. The complete nucteotide sequence of tbe ilvGMEDA operon of Escherichia coli k-12 Nucleic Acids Research. 16: 3602. DOI: 10.1093/Nar/16.8.3602 |
0.214 |
|
| 2021 |
Miles RR, Amin PH, Diaz MB, Misra J, Aukerman E, Das A, Ghosh N, Guith T, Knierman MD, Roy S, Spandau DF, Wek RC. The eIF2 kinase GCN2 directs keratinocyte collective cell migration during wound healing via coordination of reactive oxygen species and amino acids. The Journal of Biological Chemistry. 101257. PMID 34597669 DOI: 10.1016/j.jbc.2021.101257 |
0.214 |
|
| 2016 |
Kwon JJ, Willy JA, Quirin KA, Wek RC, Korc M, Yin XM, Kota J. Novel role of miR-29a in pancreatic cancer autophagy and its therapeutic potential. Oncotarget. PMID 27626694 DOI: 10.18632/Oncotarget.11928 |
0.214 |
|
| 1987 |
Lawther RP, Wek RC, Lopes JM, Pereira R, Taillon BE, Hatfield GW. The complete nucleotide sequence of theilvGMEDAoperon ofEscherichia coliK-12 Nucleic Acids Research. 15: 9108-9108. DOI: 10.1093/Nar/15.21.9108 |
0.212 |
|
| 1987 |
Lawther RP, Wek RC, Lopes JM, Pereira R, Taillon BE, Hatfield GW. The complete nucleotide sequence of the ilvGMEDA operon of Escherichia coli K-12. Nucleic Acids Research. 15: 2137-55. PMID 3550695 DOI: 10.1093/nar/15.5.2137 |
0.159 |
|
| 2021 |
Bidwell J, Tersey SA, Adaway M, Bone RN, Creecy A, Klunk A, Atkinson EG, Wek RC, Robling AG, Wallace JM, Evans-Molina C. Nmp4, a Regulator of Induced Osteoanabolism, Also Influences Insulin Secretion and Sensitivity. Calcified Tissue International. PMID 34417862 DOI: 10.1007/s00223-021-00903-7 |
0.127 |
|
| 2020 |
Augusto L, Wek RC, Sullivan WJ. Host sensing and signal transduction during Toxoplasma stage conversion. Molecular Microbiology. PMID 33118234 DOI: 10.1111/mmi.14634 |
0.118 |
|
| 2022 |
Jin D, Wek SA, Cordova RA, Wek RC, Lacombe D, Michaud V, Musier-Forsyth K. Aminoacylation-defective bi-allelic mutations in human EPRS1 associated with psychomotor developmental delay, epilepsy, and deafness. Clinical Genetics. PMID 36411955 DOI: 10.1111/cge.14269 |
0.104 |
|
| 1980 |
Sugino WM, Wek RC, Kingsbury DT. Partial nucleotide sequence similarity within species of Mycoplasma and Acholeplasma Journal of General Microbiology. 121: 333-338. PMID 7264601 |
0.047 |
|
| Hide low-probability matches. |