Jeanne A. Hardy, Ph.D.
Affiliations: | 1994-2000 | Chemistry | University of California, Berkeley, Berkeley, CA, United States |
| 2005- | Chemistry | University of Massachusetts, Amherst, Amherst, MA |
Area:
structural biology, with a major emphasis on electron microscopyWebsite:
https://hardylab.chem.umass.edu/people/Google:
"Jeanne Hardy"Mean distance: 9.44 | S | N | B | C | P |
Parents
Sign in to add mentor| Robert M. Glaeser | grad student | 2000 | UC Berkeley | |
| (Role of an alpha-helical bulge and kink in the heat shock transcription factor.) | ||||
| Hillary C. M. Nelson | grad student | 2000 | UC Berkeley | |
Children
Sign in to add trainee| Ethan R Goulart | research assistant | 2019-2022 | U Mass Amherst |
| Sravanti Vaidya | grad student | 2011 | U Mass Amherst |
| Witold Witkowski | grad student | 2005-2011 | U Mass Amherst |
| Kristen L. Huber | grad student | 2012 | U Mass Amherst |
| Samantha B. Nicholls | grad student | 2012 | U Mass Amherst |
| Elih M. Velazquez-Delgado | grad student | 2012 | U Mass Amherst |
| Muslum Yildiz | grad student | 2014 | U Mass Amherst |
| Scott Eron | grad student | 2010-2016 | U Mass Amherst |
| Kevin B Dagbay | grad student | 2010-2017 | U Mass Amherst |
| Banyuhay P. Serrano | grad student | 2010-2017 | U Mass Amherst |
| Derek MacPherson | grad student | 2012-2018 | U Mass Amherst |
| Maureen Hill | grad student | 2013-2018 | U Mass Amherst |
| Sumana Gosh | post-doc | 2008-2010 | U Mass Amherst |
| Narasimharao Meka | post-doc | 2015-2017 | U Mass Amherst |
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Publications
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| Cruz KG, Hill Eron M, Makhaik S, et al. (2024) A Non-Active-Site Inhibitor with Selectivity for Zika Virus NS2B-NS3 Protease. Acs Infectious Diseases |
| Araya LE, Soni IV, Hardy JA, et al. (2021) Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling. Acs Chemical Biology |
| Soni IV, Hardy JA. (2021) Caspase-9 Activation of Procaspase-3 but Not Procaspase-6 Is Based on the Local Context of Cleavage Site Motifs and on Sequence. Biochemistry |
| Anson F, Thayumanavan S, Hardy JA. (2021) Exogenous Introduction of Initiator and Executioner Caspases Results in Different Apoptotic Outcomes. Jacs Au. 1: 1240-1256 |
| Arias-Arias JL, MacPherson DJ, Hill ME, et al. (2020) A fluorescence activatable reporter of flavivirus NS2B-NS3 protease activity enables live imaging of infection in single cells and viral plaques. The Journal of Biological Chemistry |
| Hardy J. (2020) Targeting Rare Conformational States to Achieve Selective Caspase Protease Inhibition Biophysical Journal. 118: 160a-161a |
| Pham B, Eron SJ, Hill ME, et al. (2019) A Nanopore Approach for Analysis of Caspase-7 Activity in Cell Lysates. Biophysical Journal |
| Okerberg ES, Dagbay KB, Green JL, et al. (2019) Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP-Binding Site at the Dimer Interface of Procaspase-6. Biochemistry |
| Hill ME, Yildiz M, Hardy JA. (2018) Cysteine Disulfide Traps Reveal Distinct Conformational Ensembles in Dengue Virus NS2B-NS3 Protease. Biochemistry |
| MacPherson DJ, Mills CL, Ondrechen MJ, et al. (2018) Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis. The Journal of Biological Chemistry |