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Patrick du Souich

Affiliations: 
Université de Montréal, Montréal, Canada 
Area:
Pharmacology, Pharmaceutical Chemistry, Biochemistry
Website:
https://collation.umontreal.ca/prix-et-distinctions/emeritats/emeritats-2014/profil/udemportraits/f/patrick-du-souich/#:~:text=l%E2%80%99Universit%C3%A9%20de%20Barcelone%20en%201968%2C%20il%20obtient%20son%20doctorat%20en%201976
Google:
"Patrick du Souich"
Bio:

https://recherche.umontreal.ca/english/our-researchers/professors-directory/researcher/is/in14009/

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Parents

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Children

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Chantal Lambert grad student 1984 Université de Montréal
Ayman El-Kadi grad student 1999 Université de Montréal
Anne-Marie Bleau grad student 2002 Université de Montréal
Maxime-Mouhsine Barakat grad student 2003 Université de Montréal
Caroline Fradette grad student 2004 Université de Montréal

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Publications

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Iovu MO, Héroux L, Vergés J, et al. (2012) Effect of chondroitin sulfate on turpentine-induced down-regulation of CYP1A2 and CYP3A6. Carbohydrate Research. 355: 63-8
du Souich P, Fradette C. (2011) The effect and clinical consequences of hypoxia on cytochrome P450, membrane carrier proteins activity and expression. Expert Opinion On Drug Metabolism & Toxicology. 7: 1083-100
Fradette C, Batonga J, Teng S, et al. (2007) Animal models of acute moderate hypoxia are associated with a down-regulation of CYP1A1, 1A2, 2B4, 2C5, and 2C16 and up-regulation of CYP3A6 and P-glycoprotein in liver. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 765-71
Taherzadeh M, Fradette C, Bleau AM, et al. (2006) The 21-aminosteroid U74389G prevents the down-regulation and decrease in activity of CYP1A1, 1A2 and 3A6 induced by an inflammatory reaction Biochemical Pharmacology. 71: 366-376
Kourylko O, Fradette C, Arcand M, et al. (2006) Modulation of CYP1A2 and CYP3A6 catalytic activities by serum from rabbits with a turpentine-induced inflammatory reaction and interleukin 6. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 27-35
Levitchi M, Fradette C, Bleau AM, et al. (2004) Signal transduction pathways implicated in the decrease in CYP1A1, 1A2 and 3A6 activity produced by serum from rabbits and humans with an inflammatory reaction. Biochemical Pharmacology. 68: 573-82
Fradette C, Yamaguchi N, Du Souich P. (2004) 5-Hydroxytryptamine is biotransformed by CYP2C9, 2C19 and 2B6 to hydroxylamine, which is converted into nitric oxide. British Journal of Pharmacology. 141: 407-14
Fradette C, du Souich P. (2003) Hypoxia-inducible factor-1 and activator protein-1 modulate the upregulation of CYP3A6 induced by hypoxia. British Journal of Pharmacology. 140: 1146-54
Bleau AM, Maurel P, Pichette V, et al. (2003) Interleukin-1beta, interleukin-6, tumour necrosis factor-alpha and interferon-gamma released by a viral infection and an aseptic inflammation reduce CYP1A1, 1A2 and 3A6 expression in rabbit hepatocytes. European Journal of Pharmacology. 473: 197-206
Fradette C, Bleau AM, Pichette V, et al. (2002) Hypoxia-induced down-regulation of CYP1A1/1A2 and up-regulation of CYP3A6 involves serum mediators. British Journal of Pharmacology. 137: 881-91
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