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Caroline Fradette, Ph.D.

Affiliations: 
2004 Université de Montréal, Montréal, Canada 
Area:
Pharmacology
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Patrick du Souich grad student 2004 Université de Montréal
 (Modulation des cytochromes P450 par l'hypoxie: Mediateurs et mecanismes d'action.)

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du Souich P, Fradette C. (2011) The effect and clinical consequences of hypoxia on cytochrome P450, membrane carrier proteins activity and expression. Expert Opinion On Drug Metabolism & Toxicology. 7: 1083-100
Fradette C, Batonga J, Teng S, et al. (2007) Animal models of acute moderate hypoxia are associated with a down-regulation of CYP1A1, 1A2, 2B4, 2C5, and 2C16 and up-regulation of CYP3A6 and P-glycoprotein in liver. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 765-71
Grenier J, Fradette C, Morelli G, et al. (2006) Pomelo juice, but not cranberry juice, affects the pharmacokinetics of cyclosporine in humans. Clinical Pharmacology and Therapeutics. 79: 255-62
Taherzadeh M, Fradette C, Bleau AM, et al. (2006) The 21-aminosteroid U74389G prevents the down-regulation and decrease in activity of CYP1A1, 1A2 and 3A6 induced by an inflammatory reaction Biochemical Pharmacology. 71: 366-376
Kourylko O, Fradette C, Arcand M, et al. (2006) Modulation of CYP1A2 and CYP3A6 catalytic activities by serum from rabbits with a turpentine-induced inflammatory reaction and interleukin 6. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 27-35
Fradette C, Grenier J, Morelli G, et al. (2005) Pomelo juice but not cranberry juice affects the disposition of cyclosporine in humans Clinical Pharmacology & Therapeutics. 77
Levitchi M, Fradette C, Bleau AM, et al. (2004) Signal transduction pathways implicated in the decrease in CYP1A1, 1A2 and 3A6 activity produced by serum from rabbits and humans with an inflammatory reaction. Biochemical Pharmacology. 68: 573-82
Fradette C, Du Souich P. (2004) Effect of hypoxia on cytochrome P450 activity and expression. Current Drug Metabolism. 5: 257-71
Fradette C, Yamaguchi N, Du Souich P. (2004) 5-Hydroxytryptamine is biotransformed by CYP2C9, 2C19 and 2B6 to hydroxylamine, which is converted into nitric oxide. British Journal of Pharmacology. 141: 407-14
Fradette C, du Souich P. (2003) Hypoxia-inducible factor-1 and activator protein-1 modulate the upregulation of CYP3A6 induced by hypoxia. British Journal of Pharmacology. 140: 1146-54
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