Sergio Grinstein

Affiliations: 
University of Toronto, Toronto, ON, Canada 
Area:
Cell Biology, Biochemistry
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Children

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John H. Brumell grad student 1993-1997 Hospital for Sick Children (Microtree)
Florencia B. Schapiro grad student 2001 University of Toronto
Andrzej A. Jankowski grad student 2003 University of Toronto
Roberto J. Botelho grad student 2004 University of Toronto
Spencer A Freeman post-doc
Andras Kapus post-doc (Cell Biology Tree)
Ori Rotstein post-doc (Cell Biology Tree)
Daniela Rotin post-doc 1988-1990 Hospital for Sick Children
Sylvain Bourgoin post-doc 1990-1992 Hospital for Sick Children (Cell Biology Tree)
Gregory Fairn post-doc 2007-2012 University of Toronto
Dante Neculai post-doc 2011-2013 Hospital for Sick Children (ImmunoTree)
Michelle Maxson post-doc 2013-2023 Hospital for Sick Children (ImmunoTree)
Rich Collins research scientist 1998-2002 Hospital for Sick Children

Collaborators

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Amira Klip collaborator
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Publications

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Wu JZ, Pemberton JG, Morioka S, et al. (2025) Sorting nexin 10 regulates lysosomal ionic homeostasis via ClC-7 by controlling PI(3,5)P2. The Journal of Cell Biology. 224
Zhu H, Sydor AM, Yan BR, et al. (2025) Salmonella exploits LRRK2-dependent plasma membrane dynamics to invade host cells. Nature Communications. 16: 2329
Zhu H, Sydor AM, Boddy KC, et al. (2024) Salmonella exploits membrane reservoirs for invasion of host cells. Nature Communications. 15: 3120
Le T, Ferling I, Qiu L, et al. (2024) Redistribution of the glycocalyx exposes phagocytic determinants on apoptotic cells. Developmental Cell
Barreda D, Grinstein S, Freeman SA. (2023) Target lysis by cholesterol extraction is a rate limiting step in the resolution of phagolysosomes. European Journal of Cell Biology. 103: 151382
Case NT, Westman J, Hallett MT, et al. (2023) Respiration supports intraphagosomal filamentation and escape of from macrophages. Mbio. e0274523
Turner M, Plumb J, Merrill AR, et al. (2023) Lysosomal swelling and lysis mediate delivery of C3 toxins to their cytoplasmic targets. Molecular Microbiology
Wu JZ, Zeziulia M, Kwon W, et al. (2023) ClC-7 drives intraphagosomal chloride accumulation to support hydrolase activity and phagosome resolution. The Journal of Cell Biology. 222
Hirata Y, Cai R, Volchuk A, et al. (2023) Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis. Current Biology : Cb
Shiraishi A, Uygun V, Sharfe N, et al. (2023) Novel immunodeficiency caused by homozygous mutation in SLC19A1 encoding the reduced folate carrier. Blood
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