Roberto J. Botelho, Ph.D.

Affiliations: 
2004 University of Toronto, Toronto, ON, Canada 
 2005- Ryerson University, Toronto, Ontario, Canada 
Area:
Cell Biology
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"Roberto Botelho"
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Parents

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Sergio Grinstein grad student 2004 University of Toronto
 (Lipid signaling and the role of COPI in Fcgamma receptor-mediated phagocytosis and phagosome maturation.)

Children

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Munira Verdawala grad student 2016-2020 Ryerson University (Physics Tree)
Yuchen Zheng grad student 2021-2023 Ryerson University (Cell Biology Tree)
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Publications

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Chan V, Camardi C, Zhang K, et al. (2024) The LCLAT1/LYCAT acyltransferase is required for EGF-mediated phosphatidylinositol-3,4,5-trisphosphate generation and Akt signalling. Molecular Biology of the Cell. mbcE23090361
Cai R, Scott O, Ye G, et al. (2024) Pressure sensing of lysosomes enables control of TFEB responses in macrophages. Nature Cell Biology
Zhang K, Chan V, Botelho RJ, et al. (2023) A tail of their own: regulation of cardiolipin and phosphatidylinositol fatty acyl profile by the acyltransferase LCLAT1. Biochemical Society Transactions
Soha SA, Santhireswaran A, Huq S, et al. (2023) Improved imaging and preservation of lysosome dynamics using silver nanoparticle-enhanced fluorescence. Molecular Biology of the Cell. mbcE22060200
Mansat M, Dayam RM, Botelho RJ. (2023) Quantitative Immunofluorescence to Study Phagosome Maturation and Resolution. Methods in Molecular Biology (Clifton, N.J.). 2692: 121-137
Soffiaturo S, Choy C, Botelho RJ. (2023) Quantifying Phagocytosis by Immunofluorescence and Microscopy. Methods in Molecular Biology (Clifton, N.J.). 2692: 25-39
Boutry M, DiGiovanni LF, Demers N, et al. (2023) Arf1-PI4KIIIβ positive vesicles regulate PI(3)P signaling to facilitate lysosomal tubule fission. The Journal of Cell Biology. 222
Lo L, Uchenunu O, Botelho RJ, et al. (2022) AMPK is required for recovery from metabolic stress induced by ultrasound microbubble treatment. Iscience. 26: 105883
Saffi GT, Wang CA, Mangialardi EM, et al. (2022) Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics through VPS34 activity. The Journal of Biological Chemistry. 102187
Cabral-Dias R, Lucarelli S, Zak K, et al. (2022) Fyn and TOM1L1 are recruited to clathrin-coated pits and regulate Akt signaling. The Journal of Cell Biology. 221
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