Sergiy I. Borysov, Ph.D.

Affiliations: 
2006 University of South Florida, Tampa, FL, United States 
Area:
Molecular Biology, Biochemistry
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Thomas M. Guadagno grad student 2006 University of South Florida
 (B-Raf is an essential component of the mitotic machinery critical for activation of MAPK signaling during mitosis in Xenopus egg extracts.)
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Publications

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Fontaine SN, Martin MD, Akoury E, et al. (2015) The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics. Human Molecular Genetics. 24: 3971-81
Ari C, Borysov SI, Wu J, et al. (2014) Alzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function. Neurobiology of Aging. 35: 1839-49
Jinwal UK, Akoury E, Abisambra JF, et al. (2013) Imbalance of Hsp70 family variants fosters tau accumulation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 1450-9
Ari C, Borysov S, Wu J, et al. (2012) P3-036: Aß inhibition of kinesin 5 induces neurotransmitter and neurotrophin receptor mislocalization and dysfunction Alzheimer's & Dementia. 8: P468-P468
Borysov SI, Granic A, Padmanabhan J, et al. (2011) Alzheimer Aβ disrupts the mitotic spindle and directly inhibits mitotic microtubule motors. Cell Cycle (Georgetown, Tex.). 10: 1397-410
Potter H, Borysov S, Ari C, et al. (2011) P4-324: Aβ inhibits specific kinesin motors involved in both mitosis and neuronal function; potential implications for neurogenesis and neuroplasticity in Alzheimer's disease and Down syndrome Alzheimer's & Dementia. 7: e24-e24
Jinwal UK, O'Leary JC, Borysov SI, et al. (2010) Hsc70 rapidly engages tau after microtubule destabilization. The Journal of Biological Chemistry. 285: 16798-805
Jinwal UK, Koren J, Borysov SI, et al. (2010) The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 591-9
Potter H, Granic A, Borysov S, et al. (2010) P4-005: Alzheimer Aβ Induces Chromosome Mis-segregation, Microtubule Defects, Receptor Mis-localization, and Inhibition of Mitotic/Neuronal Kinesins: Implications for Neurogenesis and Plasticity in Neurodegenrative Diseases Alzheimer's & Dementia. 6: e22-e22
Dickey CA, O'Leary JC, Borysov S, et al. (2010) P1-370: The early involvement of chaperones in tau pathogenesis Alzheimer's & Dementia. 6: S280-S280
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