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Thomas McCown - Publications

Affiliations: 
Neurobiology University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Neuroscience Biology, Virology Biology
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47 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Bohlen MO, McCown TJ, Powell SK, El-Nahal H, Daw T, Basso MA, Sommer MA, Samulski RJ. AAV Capsid-Promoter Interactions in the Brain Translate from Rat to the Non-Human Primate. Human Gene Therapy. PMID 32940068 DOI: 10.1089/hum.2020.196  0.418
2020 Powell SK, Samulski RJ, McCown TJ. AAV Capsid-Promoter Interactions Determine CNS Cell-Selective Gene Expression In Vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 32213322 DOI: 10.1016/j.ymthe.2020.03.007  0.461
2017 Mandel RJ, Marmion DJ, Kirik D, Chu Y, Heindel C, McCown T, Gray SJ, Kordower JH. Novel oligodendroglial alpha synuclein viral vector models of multiple system atrophy: studies in rodents and nonhuman primates. Acta Neuropathologica Communications. 5: 47. PMID 28619074 DOI: 10.1186/S40478-017-0451-7  0.31
2017 Weinberg MS, Criswell HE, Powell SK, Bhatt AP, McCown TJ. Viral Vector Reprogramming of Adult Resident Striatal Oligodendrocytes into Functional Neurons. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 28202388 DOI: 10.1016/J.Ymthe.2017.01.016  0.306
2016 Powell SK, Khan N, Parker CL, Samulski RJ, Matsushima G, Gray SJ, McCown TJ. Characterization of a novel adeno-associated viral vector with preferential oligodendrocyte tropism. Gene Therapy. PMID 27628693 DOI: 10.1038/Gt.2016.62  0.481
2015 Hu P, Li Y, Sands MS, McCown T, Kafri T. Generation of a stable packaging cell line producing high-titer PPT-deleted integration-deficient lentiviral vectors. Molecular Therapy. Methods & Clinical Development. 2: 15025. PMID 26229972 DOI: 10.1038/Mtm.2015.25  0.407
2015 Powell SK, Khan N, Parker C, Jude Samulski R, Matsushima G, Gray SJ, McCown TJ. 306. Characterization of a Novel Adeno-Associated Viral Vector with Preferential Oligodendrocyte Tropism Molecular Therapy. 23: S123-S124. DOI: 10.1016/S1525-0016(16)33915-6  0.335
2014 Kantor B, McCown T, Leone P, Gray SJ. Clinical applications involving CNS gene transfer. Advances in Genetics. 87: 71-124. PMID 25311921 DOI: 10.1016/B978-0-12-800149-3.00002-0  0.459
2013 Weinberg MS, Blake BL, McCown TJ. Opposing actions of hippocampus TNFα receptors on limbic seizure susceptibility. Experimental Neurology. 247: 429-37. PMID 23333565 DOI: 10.1016/j.expneurol.2013.01.011  0.305
2013 Weinberg MS, Samulski RJ, McCown TJ. Adeno-associated virus (AAV) gene therapy for neurological disease. Neuropharmacology. 69: 82-8. PMID 22465202 DOI: 10.1016/j.neuropharm.2012.03.004  0.37
2013 Weinberg MS, McCown TJ. Current prospects and challenges for epilepsy gene therapy. Experimental Neurology. 244: 27-35. PMID 22008258 DOI: 10.1016/j.expneurol.2011.10.003  0.455
2011 Gray SJ, Choi VW, Asokan A, Haberman RA, McCown TJ, Samulski RJ. Production of recombinant adeno-associated viral vectors and use in in vitro and in vivo administration. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 4.17. PMID 21971848 DOI: 10.1002/0471142301.Ns0417S57  0.769
2011 Weinberg MS, Blake BL, Samulski RJ, McCown TJ. The influence of epileptic neuropathology and prior peripheral immunity on CNS transduction by rAAV2 and rAAV5. Gene Therapy. 18: 961-8. PMID 21490684 DOI: 10.1038/Gt.2011.49  0.46
2011 Gray SJ, Foti SB, Schwartz JW, Bachaboina L, Taylor-Blake B, Coleman J, Ehlers MD, Zylka MJ, McCown TJ, Samulski RJ. Optimizing promoters for recombinant adeno-associated virus-mediated gene expression in the peripheral and central nervous system using self-complementary vectors. Human Gene Therapy. 22: 1143-53. PMID 21476867 DOI: 10.1089/Hum.2010.245  0.727
2011 McCown TJ. Adeno-Associated Virus (AAV) Vectors in the CNS. Current Gene Therapy. 11: 181-8. PMID 21453285  0.467
2011 Kantor B, Bayer M, Ma H, Samulski J, Li C, McCown T, Kafri T. Notable reduction in illegitimate integration mediated by a PPT-deleted, nonintegrating lentiviral vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 547-56. PMID 21157436 DOI: 10.1038/Mt.2010.277  0.516
2010 Gray SJ, Blake BL, Criswell HE, Nicolson SC, Samulski RJ, McCown TJ. Directed Evolution of a Novel Adeno-associated Virus (AAV) Vector That Crosses the Seizure-compromised Blood-Brain Barrier (BBB). Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 570-578. PMID 28182880 DOI: 10.1038/mt.2009.292  0.363
2010 McCown TJ. The future of epilepsy treatment: focus on adeno-associated virus vector gene therapy. Drug News & Perspectives. 23: 281-6. PMID 20603651 DOI: 10.1358/dnp.2010.23.5.1468393  0.45
2010 Gray SJ, Blake BL, Criswell HE, Nicolson SC, Samulski RJ, McCown TJ, Li W. Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB). Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 570-8. PMID 20040913 DOI: 10.1038/Mt.2009.292  0.363
2010 Koh MT, Haberman RP, Foti S, McCown TJ, Gallagher M. Treatment strategies targeting excess hippocampal activity benefit aged rats with cognitive impairment. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 1016-25. PMID 20032967 DOI: 10.1038/Npp.2009.207  0.679
2009 Foti SB, Samulski RJ, McCown TJ. Delivering multiple gene products in the brain from a single adeno-associated virus vector. Gene Therapy. 16: 1314-9. PMID 19727140 DOI: 10.1038/Gt.2009.106  0.76
2009 McCown TJ. Adeno-associated virus vector-mediated expression and constitutive secretion of galanin suppresses limbic seizure activity. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 6: 307-11. PMID 19332324 DOI: 10.1016/j.nurt.2009.01.004  0.473
2009 Foti SB, Russek SJ, Brooks-Kayal AR, McCown TJ. Viral vector gene therapy for epilepsy Neuromethods. 40: 235-250. DOI: 10.1007/978-1-60327-263-6_13  0.744
2008 Li W, Asokan A, Wu Z, Van Dyke T, DiPrimio N, Johnson JS, Govindaswamy L, Agbandje-McKenna M, Leichtle S, Eugene Redmond D, McCown TJ, Petermann KB, Sharpless NE, Samulski RJ. Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1252-1260. PMID 28178482 DOI: 10.1038/Mt.2008.100  0.308
2008 Bayer M, Kantor B, Cockrell A, Ma H, Zeithaml B, Li X, McCown T, Kafri T. A large U3 deletion causes increased in vivo expression from a nonintegrating lentiviral vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1968-76. PMID 18797449 DOI: 10.1038/Mt.2008.199  0.419
2008 Li W, Asokan A, Wu Z, Van Dyke T, DiPrimio N, Johnson JS, Govindaswamy L, Agbandje-McKenna M, Leichtle S, Redmond DE, McCown TJ, Petermann KB, Sharpless NE, Samulski RJ. Engineering and selection of shuffled AAV genomes: a new strategy for producing targeted biological nanoparticles. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 1252-60. PMID 18500254 DOI: 10.1038/mt.2008.100  0.308
2008 Zhou X, Zeng X, Fan Z, Li C, McCown T, Samulski RJ, Xiao X. Adeno-associated virus of a single-polarity DNA genome is capable of transduction in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. 16: 494-9. PMID 18180769 DOI: 10.1038/Sj.Mt.6300397  0.431
2007 Foti S, Haberman RP, Samulski RJ, McCown TJ. Adeno-associated virus-mediated expression and constitutive secretion of NPY or NPY13-36 suppresses seizure activity in vivo. Gene Therapy. 14: 1534-6. PMID 17713567 DOI: 10.1038/Sj.Gt.3303013  0.741
2006 Choi VW, Asokan A, Haberman RA, McCown TJ, Samulski RJ. Production of recombinant adeno-associated viral vectors and use for in vitro and in vivo administration. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 4.17. PMID 18428636 DOI: 10.1002/0471142301.ns0417s35  0.773
2006 McCown TJ. Adeno-associated virus-mediated expression and constitutive secretion of galanin suppresses limbic seizure activity in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. 14: 63-8. PMID 16730475 DOI: 10.1016/j.ymthe.2006.04.004  0.387
2005 McCown TJ. Adeno-associated virus (AAV) vectors in the CNS. Current Gene Therapy. 5: 333-8. PMID 15975010 DOI: 10.2174/1566523054064995  0.475
2005 Cockrell AS, Ma H, McCown T, Kluckman KD, Thresher RJ, Kafri T. 478. A HIV-1 Based Cross-Packaging System for FIV Vectors Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.018  0.391
2004 McCown TJ. The clinical potential of antiepileptic gene therapy. Expert Opinion On Biological Therapy. 4: 1771-6. PMID 15500405 DOI: 10.1517/14712598.4.11.1771  0.426
2004 Haack K, Cockrell AS, Ma H, Israeli D, Ho SN, McCown TJ, Kafri T. Transactivator and structurally optimized inducible lentiviral vectors. Molecular Therapy : the Journal of the American Society of Gene Therapy. 10: 585-96. PMID 15336658 DOI: 10.1016/J.Ymthe.2004.06.109  0.418
2004 Cockrell AS, Fu K, Ma H, McCown T, Kafri T. 69. Closing-in on the titer gap between transient transfection and packaging cell lines Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.004  0.416
2003 Haberman RP, Samulski RJ, McCown TJ. Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion. Nature Medicine. 9: 1076-80. PMID 12858168 DOI: 10.1038/nm901  0.455
2002 Haberman RP, McCown TJ. Regulation of gene expression in adeno-associated virus vectors in the brain. Methods (San Diego, Calif.). 28: 219-26. PMID 12413420 DOI: 10.1016/S1046-2023(02)00226-8  0.445
2002 Haberman R, Criswell H, Snowdy S, Ming Z, Breese G, Samulski R, McCown T. Therapeutic liabilities of in vivo viral vector tropism: adeno-associated virus vectors, NMDAR1 antisense, and focal seizure sensitivity. Molecular Therapy : the Journal of the American Society of Gene Therapy. 6: 495-500. PMID 12377191 DOI: 10.1006/Mthe.2002.0701  0.758
2002 Fu H, Samulski RJ, McCown TJ, Picornell YJ, Fletcher D, Muenzer J. Neurological correction of lysosomal storage in a mucopolysaccharidosis IIIB mouse model by adeno-associated virus-mediated gene delivery. Molecular Therapy : the Journal of the American Society of Gene Therapy. 5: 42-9. PMID 11786044 DOI: 10.1006/Mthe.2001.0514  0.408
2001 Xu K, Ma H, McCown TJ, Verma IM, Kafri T. Generation of a stable cell line producing high-titer self-inactivating lentiviral vectors. Molecular Therapy : the Journal of the American Society of Gene Therapy. 3: 97-104. PMID 11162316 DOI: 10.1006/Mthe.2000.0238  0.364
2000 Haberman RP, McCown TJ, Samulski RJ. Novel transcriptional regulatory signals in the adeno-associated virus terminal repeat A/D junction element. Journal of Virology. 74: 8732-9. PMID 10954575 DOI: 10.1128/Jvi.74.18.8732-8739.2000  0.471
1998 Haberman RP, McCown TJ, Samulski RJ. Inducible long-term gene expression in brain with adeno-associated virus gene transfer. Gene Therapy. 5: 1604-11. PMID 10023439 DOI: 10.1038/Sj.Gt.3300782  0.564
1998 Bartlett JS, Samulski RJ, McCown TJ. Selective and rapid uptake of adeno-associated virus type 2 in brain. Human Gene Therapy. 9: 1181-6. PMID 9625257 DOI: 10.1089/hum.1998.9.8-1181  0.379
1997 Xiao X, McCown TJ, Li J, Breese GR, Morrow AL, Samulski RJ. Adeno-associated virus (AAV) vector antisense gene transfer in vivo decreases GABA(A) alpha1 containing receptors and increases inferior collicular seizure sensitivity. Brain Research. 756: 76-83. PMID 9187316 DOI: 10.1016/S0006-8993(97)00120-0  0.376
1997 Xiao X, Li J, McCown TJ, Samulski RJ. Gene transfer by adeno-associated virus vectors into the central nervous system. Experimental Neurology. 144: 113-24. PMID 9126160 DOI: 10.1006/Exnr.1996.6396  0.433
1997 Samulski RJ, During MJ, Kaplitt MG, Xiao X, Redman G, McCown T. Adeno-associated virus vectors yield long-term expression and delivery of potentially therapeutic genes into non-dividing neuronal cells Journal of Neurovirology. 3: S72.  0.445
1996 McCown TJ, Xiao X, Li J, Breese GR, Samulski RJ. Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector. Brain Research. 713: 99-107. PMID 8724980 DOI: 10.1016/0006-8993(95)01488-8  0.454
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