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Xiangbo Zhao, Ph.D.

Affiliations: 
2005 City University of New York, New York, NY, United States 
Area:
Biochemistry
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"Xiangbo Zhao"
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Richard S. Magliozzo grad student 2005 CUNY
 (The catalytic mechanism of Mycobacterium tuberculosis catalase-peroxidase (KatG) and isoniazid activation.)

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Publications

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Hersleth H, Zhao X, Magliozzo R, et al. (2014) Structural insight into the function and anti-TB pro-drug activation by KatG Acta Crystallographica Section a Foundations and Advances. 70: C707-C707
Zhao X, Hersleth HP, Zhu J, et al. (2013) Access channel residues Ser315 and Asp137 in Mycobacterium tuberculosis catalase-peroxidase (KatG) control peroxidatic activation of the pro-drug isoniazid. Chemical Communications (Cambridge, England). 49: 11650-2
Carreira M, Calvo-Sanjuán R, Sanaú M, et al. (2012) Cytotoxic hydrophilic iminophosphorane coordination compounds of d⁸ metals. Studies of their interactions with DNA and HSA. Journal of Inorganic Biochemistry. 116: 204-14
Zhao X, Khajo A, Jarrett S, et al. (2012) Specific function of the Met-Tyr-Trp adduct radical and residues Arg-418 and Asp-137 in the atypical catalase reaction of catalase-peroxidase KatG. The Journal of Biological Chemistry. 287: 37057-65
Hersleth H-, Zhao X, Magliozzo RS, et al. (2011) Combining X-ray diffraction andin situspectroscopy to study haem proteins Acta Crystallographica Section a Foundations of Crystallography. 67: C159-C160
Zhao X, Suarez J, Khajo A, et al. (2010) A radical on the Met-Tyr-Trp modification required for catalase activity in catalase-peroxidase is established by isotopic labeling and site-directed mutagenesis. Journal of the American Chemical Society. 132: 8268-9
Suarez J, Ranguelova K, Jarzecki AA, et al. (2009) An oxyferrous heme/protein-based radical intermediate is catalytically competent in the catalase reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG). The Journal of Biological Chemistry. 284: 7017-29
Zhao X, Yu S, Ranguelova K, et al. (2009) Role of the oxyferrous heme intermediate and distal side adduct radical in the catalase activity of Mycobacterium tuberculosis KatG revealed by the W107F mutant. The Journal of Biological Chemistry. 284: 7030-7
Zhao X, Yu S, Magliozzo RS. (2007) Characterization of the binding of isoniazid and analogues to Mycobacterium tuberculosis catalase-peroxidase. Biochemistry. 46: 3161-70
Kapetanaki SM, Zhao X, Yu S, et al. (2007) Modification of the active site of Mycobacterium tuberculosis KatG after disruption of the Met-Tyr-Trp cross-linked adduct. Journal of Inorganic Biochemistry. 101: 422-33
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