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Adam L. Hughes - Publications

Affiliations: 
Fred Hutchinson Cancer Research Center Fred Hutchinson Cancer Research Center, Seattle, WA, United States 
Area:
organelle morphology
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20 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Zhao S, Hughes AL, Espenshade PJ. Fission yeast Dap1 heme iron-coordinating residue Y83 is required for cytochromes P450 function. Micropublication Biology. 2022. PMID 36090151 DOI: 10.17912/micropub.biology.000631  0.618
2020 Schuler MH, Hughes AL. OPA1 and Angiogenesis: Beyond the Fusion Function. Cell Metabolism. 31: 886-887. PMID 32375059 DOI: 10.1016/J.Cmet.2020.04.014  0.304
2020 Hughes CE, Coody TK, Jeong MY, Berg JA, Winge DR, Hughes AL. Cysteine Toxicity Drives Age-Related Mitochondrial Decline by Altering Iron Homeostasis. Cell. 180: 296-310.e18. PMID 31978346 DOI: 10.1016/J.Cell.2019.12.035  0.31
2019 Goodrum JM, Lever AR, Coody TK, Gottschling DE, Hughes AL. Rsp5 and Mdm30 reshape the mitochondrial network in response to age-induced vacuole stress. Molecular Biology of the Cell. mbcE19020094. PMID 31141470 DOI: 10.1091/Mbc.E19-02-0094  0.338
2016 Carmona-Gutierrez D, Hughes AL, Madeo F, Ruckenstuhl C. The crucial impact of lysosomes in aging and longevity. Ageing Research Reviews. PMID 27125853 DOI: 10.1016/J.Arr.2016.04.009  0.314
2016 Hughes AL, Hughes CE, Henderson KA, Yazvenko N, Gottschling DE. Selective sorting and destruction of mitochondrial membrane proteins in aged yeast. Elife. 5. PMID 27097106 DOI: 10.7554/Elife.13943  0.309
2016 Hughes AL, Hughes CE, Henderson KA, Yazvenko N, Gottschling DE. Author response: Selective sorting and destruction of mitochondrial membrane proteins in aged yeast Elife. DOI: 10.7554/Elife.13943.023  0.3
2015 Rutter J, Hughes AL. Power(2): the power of yeast genetics applied to the powerhouse of the cell. Trends in Endocrinology and Metabolism: Tem. 26: 59-68. PMID 25591985 DOI: 10.1016/J.Tem.2014.12.002  0.33
2012 Hughes AL, Gottschling DE. An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast. Nature. 492: 261-5. PMID 23172144 DOI: 10.1038/Nature11654  0.318
2008 Burg JS, Powell DW, Chai R, Hughes AL, Link AJ, Espenshade PJ. Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast. Cell Metabolism. 8: 522-31. PMID 19041767 DOI: 10.1016/J.Cmet.2008.09.004  0.764
2008 Hughes AL, Stewart EV, Espenshade PJ. Identification of twenty-three mutations in fission yeast Scap that constitutively activate SREBP. Journal of Lipid Research. 49: 2001-12. PMID 18503029 DOI: 10.1194/Jlr.M800207-Jlr200  0.75
2007 Espenshade PJ, Hughes AL. Regulation of sterol synthesis in eukaryotes. Annual Review of Genetics. 41: 401-27. PMID 17666007 DOI: 10.1146/Annurev.Genet.41.110306.130315  0.703
2007 Lee H, Bien CM, Hughes AL, Espenshade PJ, Kwon-Chung KJ, Chang YC. Cobalt chloride, a hypoxia-mimicking agent, targets sterol synthesis in the pathogenic fungus Cryptococcus neoformans. Molecular Microbiology. 65: 1018-33. PMID 17645443 DOI: 10.1111/J.1365-2958.2007.05844.X  0.735
2007 Hughes AL, Lee CY, Bien CM, Espenshade PJ. 4-Methyl sterols regulate fission yeast SREBP-Scap under low oxygen and cell stress. The Journal of Biological Chemistry. 282: 24388-96. PMID 17595166 DOI: 10.1074/Jbc.M701326200  0.719
2007 Hughes AL, Powell DW, Bard M, Eckstein J, Barbuch R, Link AJ, Espenshade PJ. Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes. Cell Metabolism. 5: 143-9. PMID 17276356 DOI: 10.1016/J.Cmet.2006.12.009  0.634
2007 Hughes AL, Espenshade PJ. Insig‐independent activation of fission yeast SREBP/SCAP by 4,4‐methyl sterol intermediates The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A609-D  0.659
2007 Espenshade PJ, Hughes AL, Lee CS, Hughes BT. Oxygen‐dependent regulation of sterol regulatory element binding protein (SREBP) in fission yeast The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A608-A  0.744
2006 Todd BL, Stewart EV, Burg JS, Hughes AL, Espenshade PJ. Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast. Molecular and Cellular Biology. 26: 2817-31. PMID 16537923 DOI: 10.1128/Mcb.26.7.2817-2831.2006  0.712
2005 Hughes AL, Todd BL, Espenshade PJ. SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast. Cell. 120: 831-42. PMID 15797383 DOI: 10.1016/J.Cell.2005.01.012  0.738
2004 Warren CD, Eckley DM, Lee MS, Hanna JS, Hughes A, Peyser B, Jie C, Irizarry R, Spencer FA. S-phase checkpoint genes safeguard high-fidelity sister chromatid cohesion. Molecular Biology of the Cell. 15: 1724-35. PMID 14742710 DOI: 10.1091/Mbc.E03-09-0637  0.391
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