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Owen Pornillos, Ph.D. - Publications

Affiliations: 
2002 University of Utah, Salt Lake City, UT 
Area:
Cell Biology
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57 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Schirra RT, Dos Santos NFB, Ganser-Pornillos BK, Pornillos O. Arg18 Substitutions Reveal the Capacity of the HIV-1 Capsid Protein for Non-Fullerene Assembly. Viruses. 16. PMID 39066201 DOI: 10.3390/v16071038  0.448
2023 Piacentini J, Allen DS, Ganser-Pornillos BK, Chanda SK, Yoh SM, Pornillos O. Molecular determinants of PQBP1 binding to the HIV-1 capsid lattice. Journal of Molecular Biology. 168409. PMID 38128824 DOI: 10.1016/j.jmb.2023.168409  0.469
2023 Sarkar S, Zadrozny KK, Zadorozhnyi R, Russell RW, Quinn CM, Kleinpeter A, Ablan S, Meshkin H, Perilla JR, Freed EO, Ganser-Pornillos BK, Pornillos O, Gronenborn AM, Polenova T. Structural basis of HIV-1 maturation inhibitor binding and activity. Nature Communications. 14: 1237. PMID 36871077 DOI: 10.1038/s41467-023-36569-y  0.373
2023 Schirra RT, Dos Santos NFB, Zadrozny KK, Kucharska I, Ganser-Pornillos BK, Pornillos O. A molecular switch modulates assembly and host factor binding of the HIV-1 capsid. Nature Structural & Molecular Biology. PMID 36759579 DOI: 10.1038/s41594-022-00913-5  0.479
2022 Yu A, Lee EMY, Briggs JAG, Ganser-Pornillos BK, Pornillos O, Voth GA. Strain and rupture of HIV-1 capsids during uncoating. Proceedings of the National Academy of Sciences of the United States of America. 119: e2117781119. PMID 35238630 DOI: 10.1073/pnas.2117781119  0.368
2022 Xue G, Braczyk K, Gonçalves-Carneiro D, Dawidziak DM, Sanchez K, Ong H, Wan Y, Zadrozny KK, Ganser-Pornillos BK, Bieniasz PD, Pornillos O. Poly(ADP-ribose) potentiates ZAP antiviral activity. Plos Pathogens. 18: e1009202. PMID 35130321 DOI: 10.1371/journal.ppat.1009202  0.429
2021 Zurowska K, Alam A, Ganser-Pornillos BK, Pornillos O. Structural evidence that MOAP1 and PEG10 are derived from retrovirus/retrotransposon Gag proteins. Proteins. PMID 34357660 DOI: 10.1002/prot.26204  0.427
2021 Buckmaster MV, Zadrozny KK, Ganser-Pornillos BK, Pornillos O, Goff SP. Structural determinants of virion assembly and release in the C-terminus of the M-PMV capsid protein. Journal of Virology. JVI0061521. PMID 34287037 DOI: 10.1128/JVI.00615-21  0.451
2021 Buckmaster MV, Zadrozny KK, Ganser-Pornillos BK, Pornillos O, Goff SP. Structural determinants of virion assembly and release in the C-terminus of the M-PMV capsid protein. Journal of Virology. JVI0061521. PMID 34287037 DOI: 10.1128/JVI.00615-21  0.451
2020 Eschbach JE, Elliott JL, Li W, Zadrozny KK, Davis K, Mohammed SJ, Lawson DQ, Pornillos O, Engelman AN, Kutluay SB. Capsid lattice destabilization leads to premature loss of the viral genome and integrase enzyme during HIV-1 infection. Journal of Virology. PMID 33115869 DOI: 10.1128/JVI.00984-20  0.317
2020 Christensen DE, Ganser-Pornillos BK, Johnson JS, Pornillos O, Sundquist WI. Reconstitution and visualization of HIV-1 capsid-dependent replication and integration in vitro. Science (New York, N.Y.). 370. PMID 33033190 DOI: 10.1126/science.abc8420  0.617
2020 Ward AE, Kiessling V, Pornillos O, White JM, Ganser-Pornillos BK, Tamm LK. HIV-cell membrane fusion intermediates are restricted by Serincs as revealed by cryo electron and TIRF microscopy. The Journal of Biological Chemistry. PMID 32788212 DOI: 10.1074/Jbc.Ra120.014466  0.417
2020 Yu A, Skorupka KA, Pak AJ, Ganser-Pornillos BK, Pornillos O, Voth GA. TRIM5α self-assembly and compartmentalization of the HIV-1 viral capsid. Nature Communications. 11: 1307. PMID 32161265 DOI: 10.1038/S41467-020-15106-1  0.509
2020 Yu A, Skorupka K, Pak A, Ganser-Pornillos BK, Pornillos O, Voth GA. Coarse-Grained Molecular Dynamics Simulations of TRIM5α Self-Assembly and Restriction of HIV Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.2840  0.393
2019 Skorupka KA, Roganowicz MD, Christensen DE, Wan Y, Pornillos O, Ganser-Pornillos BK. Hierarchical assembly governs TRIM5α recognition of HIV-1 and retroviral capsids. Science Advances. 5: eaaw3631. PMID 31807695 DOI: 10.1126/Sciadv.Aaw3631  0.54
2019 Kucharska I, Ding P, Zadrozny KK, Dick RA, Summers MF, Ganser-Pornillos BK, Pornillos O. Biochemical reconstitution of HIV-1 assembly and maturation. Journal of Virology. PMID 31801870 DOI: 10.1128/Jvi.01844-19  0.539
2019 Kueck T, Bloyet LM, Cassella E, Zang T, Schmidt F, Brusic V, Tekes G, Pornillos O, Whelan SPJ, Bieniasz PD. Vesicular stomatitis virus transcription is inhibited by TRIM69 in the interferon-induced antiviral state. Journal of Virology. PMID 31578292 DOI: 10.1128/Jvi.01372-19  0.413
2019 Ganser-Pornillos BK, Pornillos O. Restriction of HIV-1 and other retroviruses by TRIM5. Nature Reviews. Microbiology. PMID 31312031 DOI: 10.1038/S41579-019-0225-2  0.51
2019 Pornillos O, Ganser-Pornillos BK. Maturation of retroviruses. Current Opinion in Virology. 36: 47-55. PMID 31185449 DOI: 10.1016/J.Coviro.2019.05.004  0.466
2019 Stevens M, Franke B, Skorupka KA, Cafiso DS, Pornillos O, Mayans O, Norman DG. Exploration of the TRIM Fold of MuRF1 Using EPR Reveals a Canonical Antiparallel Structure and Extended COS-Box. Journal of Molecular Biology. PMID 31125568 DOI: 10.1016/J.Jmb.2019.05.025  0.47
2019 Yu A, Ganser-Pornillos BK, Pornillos O, Voth GA. Coarse-Grained and Atomistic Simulations of the Mature HIV Capsid and Related Restriction Factors Biophysical Journal. 116: 459a. DOI: 10.1016/J.Bpj.2018.11.2477  0.408
2018 Sundquist WI, Pornillos O. Retrovirus Restriction by TRIM5α: RINGside at a Cage Fight. Cell Host & Microbe. 24: 751-753. PMID 30543772 DOI: 10.1016/J.Chom.2018.11.013  0.606
2018 Sanchez JG, Sparrer KMJ, Chiang C, Reis RA, Chiang JJ, Zurenski MA, Wan Y, Gack MU, Pornillos O. TRIM25 binds RNA to modulate cellular anti-viral defense. Journal of Molecular Biology. PMID 30342007 DOI: 10.1016/J.Jmb.2018.10.003  0.44
2018 Dick RA, Zadrozny KK, Xu C, Schur FKM, Lyddon TD, Ricana CL, Wagner JM, Perilla JR, Ganser-Pornillos BK, Johnson MC, Pornillos O, Vogt VM. Author Correction: Inositol phosphates are assembly co-factors for HIV-1. Nature. PMID 30158708 DOI: 10.1038/S41586-018-0505-4  0.472
2018 Dick RA, Zadrozny KK, Xu C, Schur FKM, Lyddon TD, Ricana CL, Wagner JM, Perilla JR, Ganser-Pornillos BK, Johnson MC, Pornillos O, Vogt VM. Inositol phosphates are assembly co-factors for HIV-1. Nature. PMID 30069050 DOI: 10.1038/S41586-018-0396-4  0.6
2018 Buffone C, Martinez-Lopez A, Fricke T, Opp S, Severgnini M, Cifola I, Petiti L, Frabetti S, Skorupka K, Zadrozny KK, Ganser-Pornillos BK, Pornillos O, Di Nunzio F, Diaz-Griffero F. Nup153 Unlocks the Nuclear Pore Complex for HIV-1 Nuclear Translocation in Non-dividing Cells. Journal of Virology. PMID 29997211 DOI: 10.1128/Jvi.00648-18  0.515
2017 Wagner JM, Christensen DE, Bhattacharya A, Dawidziak DM, Roganowicz MD, Wan Y, Pumroy RA, Demeler B, Ivanov DN, Ganser-Pornillos BK, Sundquist WI, Pornillos O. A general model for retroviral capsid pattern recognition by TRIM5 proteins. Journal of Virology. PMID 29187540 DOI: 10.1128/Jvi.01563-17  0.737
2017 Roganowicz MD, Komurlu S, Mukherjee S, Plewka J, Alam SL, Skorupka KA, Wan Y, Dawidowski D, Cafiso DS, Ganser-Pornillos BK, Campbell EM, Pornillos O. TRIM5α SPRY/coiled-coil interactions optimize avid retroviral capsid recognition. Plos Pathogens. 13: e1006686. PMID 29040325 DOI: 10.1371/Journal.Ppat.1006686  0.547
2017 Sparrer KMJ, Gableske S, Zurenski MA, Parker ZM, Full F, Baumgart GJ, Kato J, Pacheco-Rodriguez G, Liang C, Pornillos O, Moss J, Vaughan M, Gack MU. TRIM23 mediates virus-induced autophagy via activation of TBK1. Nature Microbiology. PMID 28871090 DOI: 10.1038/S41564-017-0017-2  0.419
2017 Dawidziak DM, Sanchez JG, Wagner JM, Ganser-Pornillos BK, Pornillos O. Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase. Proteins. PMID 28681414 DOI: 10.1002/Prot.25348  0.428
2017 Janczyk PŁ, Skorupka KA, Tooley JG, Matson DR, Kestner CA, West T, Pornillos O, Stukenberg PT. Mechanism of Ska Recruitment by Ndc80 Complexes to Kinetochores. Developmental Cell. 41: 438-449.e4. PMID 28535377 DOI: 10.1016/J.Devcel.2017.04.020  0.34
2016 Sanchez JG, Chiang JJ, Sparrer KM, Alam SL, Chi M, Roganowicz MD, Sankaran B, Gack MU, Pornillos O. Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway. Cell Reports. PMID 27425606 DOI: 10.1016/J.Celrep.2016.06.070  0.459
2016 Wagner JM, Zadrozny KK, Chrustowicz J, Purdy MD, Yeager M, Ganser-Pornillos BK, Pornillos O. Crystal structure of an HIV assembly and maturation switch. Elife. 5. PMID 27416583 DOI: 10.7554/Elife.17063  0.54
2016 Li YL, Chandrasekaran V, Carter SD, Woodward CL, Christensen DE, Dryden KA, Pornillos O, Yeager M, Ganser-Pornillos BK, Jensen GJ, Sundquist WI. Primate TRIM5 proteins form hexagonal nets 1 on HIV-1 capsids. Elife. 5. PMID 27253068 DOI: 10.7554/Elife.16269  0.735
2016 Wagner JM, Roganowicz MD, Skorupka K, Alam SL, Christensen DE, Doss GL, Wan Y, Frank GA, Ganser-Pornillos BK, Sundquist WI, Pornillos O. Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α. Elife. 5. PMID 27253059 DOI: 10.7554/Elife.16309  0.676
2016 Wagner JM, Zadrozny KK, Chrustowicz J, Purdy MD, Yeager M, Ganser-Pornillos BK, Pornillos O. Author response: Crystal structure of an HIV assembly and maturation switch Elife. DOI: 10.7554/Elife.17063.020  0.439
2016 Wagner JM, Roganowicz MD, Skorupka K, Alam SL, Christensen D, Doss G, Wan Y, Frank GA, Ganser-Pornillos BK, Sundquist WI, Pornillos O. Author response: Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α Elife. DOI: 10.7554/Elife.16309.031  0.598
2016 Li Y, Chandrasekaran V, Carter SD, Woodward CL, Christensen DE, Dryden KA, Pornillos O, Yeager M, Ganser-Pornillos BK, Jensen GJ, Sundquist WI. Author response: Primate TRIM5 proteins form hexagonal nets on HIV-1 capsids Elife. DOI: 10.7554/Elife.16269.022  0.654
2015 Gres AT, Kirby KA, KewalRamani VN, Tanner JJ, Pornillos O, Sarafianos SG. STRUCTURAL VIROLOGY. X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability. Science (New York, N.Y.). 349: 99-103. PMID 26044298 DOI: 10.1126/Science.Aaa5936  0.445
2014 Bhattacharya A, Alam SL, Fricke T, Zadrozny K, Sedzicki J, Taylor AB, Demeler B, Pornillos O, Ganser-Pornillos BK, Diaz-Griffero F, Ivanov DN, Yeager M. Structural basis of HIV-1 capsid recognition by PF74 and CPSF6. Proceedings of the National Academy of Sciences of the United States of America. 111: 18625-30. PMID 25518861 DOI: 10.1073/Pnas.1419945112  0.574
2014 Sanchez JG, Okreglicka K, Chandrasekaran V, Welker JM, Sundquist WI, Pornillos O. The tripartite motif coiled-coil is an elongated antiparallel hairpin dimer. Proceedings of the National Academy of Sciences of the United States of America. 111: 2494-9. PMID 24550273 DOI: 10.1073/Pnas.1318962111  0.701
2014 Gres A, Kirby K, Hachiya A, Michailidis E, Pornillos O, Sugiura W, Lee K, KewalRamani V, Tanner J, Sarafianos S. Native Hexameric Full-Length HIV-1 Capsid: Crystal Structure and Drug Targeting Acta Crystallographica Section a Foundations and Advances. 70: C696-C696. DOI: 10.1107/S2053273314093036  0.488
2013 Ganser-Pornillos BK, Pornillos O, Chandrasekaran V, Cheng A, Sundquist WI, Yeager M. The HIV-1 Capsid: Assembly and Restriction by TRIM5α Biophysical Journal. 104: 12a. DOI: 10.1016/J.Bpj.2012.11.096  0.676
2012 Ganser-Pornillos BK, Yeager M, Pornillos O. Assembly and architecture of HIV. Advances in Experimental Medicine and Biology. 726: 441-65. PMID 22297526 DOI: 10.1007/978-1-4614-0980-9_20  0.565
2011 Pornillos O, Ganser-Pornillos BK, Yeager M. Atomic-level modelling of the HIV capsid. Nature. 469: 424-7. PMID 21248851 DOI: 10.1038/Nature09640  0.571
2011 Ganser-Pornillos BK, Chandrasekaran V, Pornillos O, Sodroski JG, Sundquist WI, Yeager M. Hexagonal assembly of a restricting TRIM5alpha protein. Proceedings of the National Academy of Sciences of the United States of America. 108: 534-9. PMID 21187419 DOI: 10.1073/Pnas.1013426108  0.712
2010 Pornillos O, Ganser-Pornillos BK, Banumathi S, Hua Y, Yeager M. Disulfide bond stabilization of the hexameric capsomer of human immunodeficiency virus. Journal of Molecular Biology. 401: 985-95. PMID 20600115 DOI: 10.1016/J.Jmb.2010.06.042  0.454
2009 Pornillos O, Ganser-Pornillos BK, Kelly BN, Hua Y, Whitby FG, Stout CD, Sundquist WI, Hill CP, Yeager M. X-ray structures of the hexameric building block of the HIV capsid. Cell. 137: 1282-92. PMID 19523676 DOI: 10.1016/J.Cell.2009.04.063  0.7
2007 Chen YJ, Pornillos O, Lieu S, Ma C, Chen AP, Chang G. X-ray structure of EmrE supports dual topology model. Proceedings of the National Academy of Sciences of the United States of America. 104: 18999-9004. PMID 18024586 DOI: 10.1073/Pnas.0709387104  0.349
2006 Pornillos O, Chang G. Inverted repeat domains in membrane proteins. Febs Letters. 580: 358-62. PMID 16406365 DOI: 10.1016/J.Febslet.2005.12.054  0.377
2005 Pornillos O, Chen YJ, Chen AP, Chang G. X-ray structure of the EmrE multidrug transporter in complex with a substrate. Science (New York, N.Y.). 310: 1950-3. PMID 16373573 DOI: 10.1126/Science.1119776  0.307
2003 Pornillos O, Higginson DS, Stray KM, Fisher RD, Garrus JE, Payne M, He GP, Wang HE, Morham SG, Sundquist WI. HIV Gag mimics the Tsg101-recruiting activity of the human Hrs protein. The Journal of Cell Biology. 162: 425-34. PMID 12900394 DOI: 10.1083/Jcb.200302138  0.716
2002 Pornillos O, Garrus JE, Sundquist WI. Mechanisms of enveloped RNA virus budding. Trends in Cell Biology. 12: 569-79. PMID 12495845 DOI: 10.1016/S0962-8924(02)02402-9  0.619
2002 Pornillos O, Alam SL, Davis DR, Sundquist WI. Structure of the Tsg101 UEV domain in complex with the PTAP motif of the HIV-1 p6 protein. Nature Structural Biology. 9: 812-7. PMID 12379843 DOI: 10.1038/Nsb856  0.703
2002 Pornillos O, Alam SL, Rich RL, Myszka DG, Davis DR, Sundquist WI. Structure and functional interactions of the Tsg101 UEV domain. The Embo Journal. 21: 2397-406. PMID 12006492 DOI: 10.1093/Emboj/21.10.2397  0.684
2001 Garrus JE, von Schwedler UK, Pornillos OW, Morham SG, Zavitz KH, Wang HE, Wettstein DA, Stray KM, Côté M, Rich RL, Myszka DG, Sundquist WI. Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding. Cell. 107: 55-65. PMID 11595185 DOI: 10.1016/S0092-8674(01)00506-2  0.688
2001 Jenkins Y, Pornillos O, Rich RL, Myszka DG, Sundquist WI, Malim MH. Biochemical analyses of the interactions between human immunodeficiency virus type 1 Vpr and p6(Gag). Journal of Virology. 75: 10537-42. PMID 11581428 DOI: 10.1128/Jvi.75.21.10537-10542.2001  0.649
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