| Year |
Citation |
Score |
| 2022 |
Kronert WA, Hsu KH, Madan A, Sarsoza F, Cammarato A, Bernstein SI. Myosin Transducer Inter-Strand Communication Is Critical for Normal ATPase Activity and Myofibril Structure. Biology. 11. PMID 36009764 DOI: 10.3390/biology11081137 |
0.363 |
|
| 2022 |
Trujillo AS, Hsu KH, Viswanathan MC, Cammarato A, Bernstein SI. The R369 Myosin Residue within Loop 4 Is Critical for Actin Binding and Muscle Function in . International Journal of Molecular Sciences. 23. PMID 35269675 DOI: 10.3390/ijms23052533 |
0.54 |
|
| 2021 |
Trujillo AS, Hsu KH, Puthawala J, Viswanathan MC, Loya A, Irving TC, Cammarato A, Swank DM, Bernstein SI. Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation in . Molecular Biology of the Cell. mbcE21020088. PMID 34081531 DOI: 10.1091/mbc.E21-02-0088 |
0.447 |
|
| 2021 |
Bell KM, Huang A, Kronert WA, Bernstein SI, Swank DM. Prolonged Myosin Binding Increases Muscle Stiffness in Drosophila Models of Freeman-Sheldon Syndrome. Biophysical Journal. PMID 33524372 DOI: 10.1016/j.bpj.2020.12.033 |
0.529 |
|
| 2020 |
Bloemink MJ, Hsu KH, Geeves MA, Bernstein SI. Alternative N-terminal regions of myosin heavy chain II regulate communication of the purine binding loop with the essential light chain. The Journal of Biological Chemistry. PMID 32817166 DOI: 10.1074/Jbc.Ra120.014684 |
0.463 |
|
| 2020 |
Guo Y, Kronert WA, Hsu KH, Huang A, Sarsoza F, Bell KM, Suggs JA, Swank DM, Bernstein SI. Drosophila myosin mutants model the disparate severity of type 1 and type 2B distal arthrogryposis and indicate an enhanced actin affinity mechanism. Skeletal Muscle. 10: 24. PMID 32799913 DOI: 10.1186/S13395-020-00241-6 |
0.412 |
|
| 2020 |
Suggs JA, Manalo K, Melkani GC, Melkani A, Foster DB, Bernstein SI. Manipulating Levels of Stress‐Response Proteins in a Drosophila Model of Myosin‐Based Inclusion Body Myopathy 3 Worsens Muscle Dysfunction The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.07423 |
0.518 |
|
| 2019 |
Caldwell JT, Mermelstein DJ, Walker RC, Bernstein SI, Huxford T. X-ray crystallographic and molecular dynamic analyses of Drosophila melanogaster embryonic muscle myosin define domains responsible for isoform-specific properties. Journal of Molecular Biology. PMID 31786266 DOI: 10.1016/J.Jmb.2019.11.013 |
0.804 |
|
| 2019 |
Bell KM, Kronert WA, Huang A, Bernstein SI, Swank DM. The R249Q hypertrophic cardiomyopathy myosin mutation decreases contractility in Drosophila by impeding force production. The Journal of Physiology. PMID 30950055 DOI: 10.1113/Jp277333 |
0.592 |
|
| 2018 |
Rao DS, Kronert WA, Guo Y, Hsu KH, Sarsoza F, Bernstein SI. Reductions in ATPase activity, actin sliding velocity and myofibril stability yield muscle dysfunction in Drosophila models of myosin-based Freeman Sheldon syndrome. Molecular Biology of the Cell. mbcE18080526. PMID 30379605 DOI: 10.1091/Mbc.E18-08-0526 |
0.553 |
|
| 2018 |
Chandran S, Suggs JA, Wang BJ, Han A, Bhide S, Cryderman DE, Moore SA, Bernstein SI, Wallrath LL, Melkani GC. Suppression of myopathic lamin mutations by muscle-specific activation of AMPK and modulation of downstream signaling. Human Molecular Genetics. PMID 30239736 DOI: 10.1093/Hmg/Ddy332 |
0.578 |
|
| 2018 |
Kronert WA, Bell KM, Viswanathan MC, Melkani GC, Trujillo AS, Huang A, Melkani A, Cammarato A, Swank DM, Bernstein SI. Prolonged cross-bridge binding triggers muscle dysfunction in a fly model of myosin-based hypertrophic cardiomyopathy. Elife. 7. PMID 30102150 DOI: 10.7554/Elife.38064 |
0.555 |
|
| 2018 |
Lee KH, Sulbarán G, Yang S, Mun JY, Alamo L, Pinto A, Sato O, Ikebe M, Liu X, Korn ED, Sarsoza F, Bernstein SI, Padrón R, Craig R. Interacting-heads motif has been conserved as a mechanism of myosin II inhibition since before the origin of animals. Proceedings of the National Academy of Sciences of the United States of America. PMID 29444861 DOI: 10.1073/Pnas.1715247115 |
0.491 |
|
| 2018 |
Kronert WA, Bell KM, Viswanathan MC, Melkani GC, Trujillo AS, Huang A, Melkani A, Cammarato A, Swank DM, Bernstein SI. Author response: Prolonged cross-bridge binding triggers muscle dysfunction in a Drosophila model of myosin-based hypertrophic cardiomyopathy Elife. DOI: 10.7554/Elife.38064.025 |
0.503 |
|
| 2018 |
Hsu KH, Trujillo A, Irving TC, Bernstein SI. Structural and Biochemical Mechanisms of Myosin-Induced Dilated Cardiomyopathy Biophysical Journal. 114: 383a. DOI: 10.1016/J.Bpj.2017.11.2119 |
0.342 |
|
| 2017 |
Viswanathan MC, Tham RC, Kronert WA, Sarsoza F, Trujillo AS, Cammarato A, Bernstein SI. Myosin storage myopathy mutations yield defective myosin filament assembly in vitro and disrupted myofibrillar structure and function in vivo. Human Molecular Genetics. PMID 28973424 DOI: 10.1093/Hmg/Ddx359 |
0.599 |
|
| 2017 |
Melkani GC, Bhide S, Han A, Vyas J, Livelo C, Bodmer R, Bernstein SI. TRiC/CCT chaperonins are essential for maintaining myofibril organization, cardiac physiological rhythm, and life span. Febs Letters. PMID 28963798 DOI: 10.1002/1873-3468.12860 |
0.316 |
|
| 2017 |
Suggs JA, Melkani GC, Glasheen BM, Detor MM, Melkani A, Marsan NP, Swank DM, Bernstein SI. A Drosophila model of dominant inclusion body myopathy 3 shows diminished myosin kinetics that reduce muscle power and yield myofibrillar defects. Disease Models & Mechanisms. PMID 28258125 DOI: 10.1242/Dmm.028050 |
0.58 |
|
| 2017 |
Cannon L, Zambon AC, Cammarato A, Zhang Z, Vogler G, Munoz M, Taylor E, Cartry J, Bernstein SI, Melov S, Bodmer R. Expression patterns of cardiac aging in Drosophila. Aging Cell. 16: 82-92. PMID 28090760 DOI: 10.1111/Acel.12559 |
0.32 |
|
| 2017 |
Viswanathan MC, Tham R, Kronert WA, Schmidt W, Sarsoza F, Trujillo AS, Bernstein SI, Cammarato A. Expression of Myosin Storage Myopathy Mutations in Drosophila Disrupts Muscle Function, Myofibrillar Structure and Causes Defects in Thick Filament Assembly Biophysical Journal. 112: 117a. DOI: 10.1016/J.Bpj.2016.11.660 |
0.575 |
|
| 2017 |
Caldwell JT, Huxford T, Melkani G, Bernstein S. X-Ray Crystallography Structures of Drosophila Striated Muscle Myosin II Biophysical Journal. 112: 266a. DOI: 10.1016/J.Bpj.2016.11.1442 |
0.82 |
|
| 2017 |
Trujillo AS, Kronert WA, Bell K, Viswanathan MC, Melkani GC, Melkani A, Cammarato A, Swank DM, Bernstein SI. A R146N Hypertrophic Cardiomyopathy Myosin Mutation Disrupts Myosin Function, Myofibrillar Structure, and Cardiac Contraction in Drosophila Biophysical Journal. 112: 264a. DOI: 10.1016/J.Bpj.2016.11.1435 |
0.491 |
|
| 2016 |
Achal M, Trujillo AS, Melkani GC, Farman GP, Ocorr K, Viswanathan MC, Kaushik G, Newhard CS, Glasheen BM, Melkani A, Suggs JA, Moore JR, Swank DM, Bodmer R, Cammarato A, ... Bernstein SI, et al. A restrictive cardiomyopathy mutation in an invariant proline at the myosin head/rod junction enhances head flexibility and function, yielding muscle defects in Drosophila. Journal of Molecular Biology. PMID 27107639 DOI: 10.1016/J.Jmb.2016.04.021 |
0.622 |
|
| 2016 |
Kooij V, Viswanathan MC, Lee DI, Rainer PP, Schmidt W, Kronert WA, Harding SE, Kass DA, Bernstein SI, Van Eyk JE, Cammarato A. Profilin modulates sarcomeric organization and mediates cardiomyocyte hypertrophy. Cardiovascular Research. 110: 238-48. PMID 26956799 DOI: 10.1093/Cvr/Cvw050 |
0.376 |
|
| 2016 |
Bloemink MJ, Melkani GC, Bernstein SI, Geeves MA. The Relay/Converter Interface Influences Hydrolysis of ATP by Skeletal Muscle Myosin II. The Journal of Biological Chemistry. 291: 1763-73. PMID 26586917 DOI: 10.1074/Jbc.M115.688002 |
0.508 |
|
| 2016 |
Lee K, Yang S, Liu X, Korn ED, Sarsoza F, Bernstein SI, Pollard L, Lord MJ, Trybus KM, Craig R. Myosin II Head Interaction in Primitive Species Biophysical Journal. 110: 615a. DOI: 10.1016/J.Bpj.2015.11.3299 |
0.49 |
|
| 2016 |
Bell KM, Kronert WA, Guo Y, Rao D, Huang A, Bernstein SI, Swank DM. The Muscle Mechanical Basis of Freeman-Sheldon Syndrome Biophysical Journal. 110: 14a. DOI: 10.1016/J.Bpj.2015.11.134 |
0.589 |
|
| 2015 |
Kronert WA, Melkani GC, Melkani A, Bernstein SI. A Failure to Communicate: MYOSIN RESIDUES INVOLVED IN HYPERTROPHIC CARDIOMYOPATHY AFFECT INTER-DOMAIN INTERACTION. The Journal of Biological Chemistry. 290: 29270-80. PMID 26446785 DOI: 10.1074/Jbc.M115.681874 |
0.542 |
|
| 2015 |
Kaushik G, Spenlehauer A, Sessions AO, Trujillo AS, Fuhrmann A, Fu Z, Venkatraman V, Pohl D, Tuler J, Wang M, Lakatta EG, Ocorr K, Bodmer R, Bernstein SI, Van Eyk JE, et al. Vinculin network-mediated cytoskeletal remodeling regulates contractile function in the aging heart. Science Translational Medicine. 7: 292ra99. PMID 26084806 DOI: 10.1126/Scitranslmed.Aaa5843 |
0.307 |
|
| 2015 |
Viswanathan MC, Kronert W, Melkani G, Melkani A, Cammarato A, Bernstein S. The R146N and R249Q Myosin Mutations Disrupt Motor Function and Myofibrillar Structure and cause Cardiomyopathy in Drosophila Biophysical Journal. 108: 445a. DOI: 10.1016/J.Bpj.2014.11.2431 |
0.502 |
|
| 2015 |
Suggs JA, Melkani GC, Melkani A, Ratliff EP, Foster DB, Bernstein SI. A Drosophila Model of Myosin-Based Inclusion Body Myopathy Type 3: Effects on Muscle Structure, Muscle Function and Aggregated Protein Profiles Biophysical Journal. 108: 304a. DOI: 10.1016/J.Bpj.2014.11.1651 |
0.57 |
|
| 2015 |
Bell K, Kronert WA, Bernstein SI, Swank DM. The R249Q and R146N Hypertrophic Cardiomyopathy Myosin Mutations Decrease Muscle Force and Power Generation Biophysical Journal. 108: 303a-304a. DOI: 10.1016/J.Bpj.2014.11.1650 |
0.518 |
|
| 2014 |
Iwamoto H, Trombitás K, Yagi N, Suggs JA, Bernstein SI. X-ray diffraction from flight muscle with a headless myosin mutation: implications for interpreting reflection patterns. Frontiers in Physiology. 5: 416. PMID 25400584 DOI: 10.3389/Fphys.2014.00416 |
0.564 |
|
| 2014 |
Lee CF, Melkani GC, Bernstein SI. The UNC-45 myosin chaperone: from worms to flies to vertebrates. International Review of Cell and Molecular Biology. 313: 103-44. PMID 25376491 DOI: 10.1016/B978-0-12-800177-6.00004-9 |
0.551 |
|
| 2014 |
Smith DA, Carland CR, Guo Y, Bernstein SI. Getting folded: chaperone proteins in muscle development, maintenance and disease. Anatomical Record (Hoboken, N.J. : 2007). 297: 1637-49. PMID 25125177 DOI: 10.1002/Ar.22980 |
0.545 |
|
| 2014 |
Kronert WA, Melkani GC, Melkani A, Bernstein SI. Mapping interactions between myosin relay and converter domains that power muscle function. The Journal of Biological Chemistry. 289: 12779-90. PMID 24627474 DOI: 10.1074/Jbc.M114.550673 |
0.589 |
|
| 2014 |
Iwamoto H, Trombitás K, Yagi N, Suggs JA, Bernstein SI. X-ray diffraction from flight muscle with a headless myosin mutation: Implications for interpreting reflection patterns Frontiers in Physiology. 5. DOI: 10.3389/fphys.2014.00416 |
0.378 |
|
| 2014 |
Kaushik G, Spenlehauer A, Sessions A, Pohl D, Trujillo A, Bernstein SI, Bodmer R, Cammarato A, Engler AJ. Vinculin-Mediated Cytoskeletal Remodeling Modulates Cardiac Morphology and Contractile Function During Ageing Biophysical Journal. 106: 778a. DOI: 10.1016/J.Bpj.2013.11.4264 |
0.38 |
|
| 2014 |
Viswanathan MC, Kronert WA, Melkani GC, Cammarato A, Bernstein SI. Myosin Storage Myopathy Mutations Disrupt Myofibrillar Assembly/ Stability and Cause Progressive Muscle Degeneration in a Drosophila Model Biophysical Journal. 106: 777a. DOI: 10.1016/J.Bpj.2013.11.4261 |
0.555 |
|
| 2014 |
Caldwell JT, Melkani G, Bernstein SI, Huxford T. X-Ray Structure Determination of the First Insect Skeletal Muscle Myosin II Biophysical Journal. 106: 45a. DOI: 10.1016/J.Bpj.2013.11.330 |
0.815 |
|
| 2013 |
Melkani GC, Trujillo AS, Ramos R, Bodmer R, Bernstein SI, Ocorr K. Huntington's disease induced cardiac amyloidosis is reversed by modulating protein folding and oxidative stress pathways in the Drosophila heart. Plos Genetics. 9: e1004024. PMID 24367279 DOI: 10.1371/Journal.Pgen.1004024 |
0.348 |
|
| 2013 |
Xie HB, Cammarato A, Rajasekaran NS, Zhang H, Suggs JA, Lin HC, Bernstein SI, Benjamin IJ, Golic KG. The NADPH metabolic network regulates human αB-crystallin cardiomyopathy and reductive stress in Drosophila melanogaster. Plos Genetics. 9: e1003544. PMID 23818860 DOI: 10.1371/Journal.Pgen.1003544 |
0.41 |
|
| 2013 |
Trujillo AS, Kalvakuri S, Suggs JA, Giang S, Bodmer R, Bernstein SI, Melkani GC. Exploration and Suppression of Tau-Induced Cardiac and Skeletal Muscle Defects in a Drosophila Model Biophysical Journal. 104: 486a. DOI: 10.1016/J.Bpj.2012.11.2680 |
0.451 |
|
| 2013 |
Melkani GC, Suggs JA, Ramos R, Bernstein SI. Alleviation of Skeletal Muscle Defects Induced by Huntington's Disease-causing Amyloid by Modulating TOR Pathway in a Drosophila Model Biophysical Journal. 104: 483a. DOI: 10.1016/J.Bpj.2012.11.2668 |
0.553 |
|
| 2013 |
Melkani GC, Kronert WA, Melkani A, Bernstein SI. Defining Myosin Relay Domain Interactions with the Converter Domain and with the SH1-SH2 Helix Region and their Significance in Muscle Contraction Biophysical Journal. 104: 307a. DOI: 10.1016/J.Bpj.2012.11.1708 |
0.575 |
|
| 2012 |
Wang Y, Melkani GC, Suggs JA, Melkani A, Kronert WA, Cammarato A, Bernstein SI. Expression of the inclusion body myopathy 3 mutation in Drosophila depresses myosin function and stability and recapitulates muscle inclusions and weakness Molecular Biology of the Cell. 23: 2057-2065. PMID 22496423 DOI: 10.1091/Mbc.E12-02-0120 |
0.622 |
|
| 2012 |
Bernstein SI, Benian GM. Introduction to methods in invertebrate muscle biology. Methods (San Diego, Calif.). 56: 1-2. PMID 22405137 DOI: 10.1016/J.Ymeth.2012.02.014 |
0.531 |
|
| 2012 |
Kronert WA, Melkani GC, Melkani A, Bernstein SI. Alternative relay and converter domains tune native muscle myosin isoform function in Drosophila. Journal of Molecular Biology. 416: 543-57. PMID 22226837 DOI: 10.1016/J.Jmb.2011.12.044 |
0.63 |
|
| 2012 |
Kaushik G, Zambon AC, Fuhrmann A, Bernstein SI, Bodmer R, Engler AJ, Cammarato A. Measuring passive myocardial stiffness in Drosophila melanogaster to investigate diastolic dysfunction. Journal of Cellular and Molecular Medicine. 16: 1656-62. PMID 22225769 DOI: 10.1111/J.1582-4934.2011.01517.X |
0.375 |
|
| 2012 |
Caldwell JT, Melkani GC, Huxford T, Bernstein SI. Transgenic expression and purification of myosin isoforms using the Drosophila melanogaster indirect flight muscle system. Methods (San Diego, Calif.). 56: 25-32. PMID 22178692 DOI: 10.1016/J.Ymeth.2011.12.002 |
0.812 |
|
| 2012 |
Becker KD, Bernstein SI. Genetic and transgenic approaches to dissecting muscle development and contractility using the Drosophila model system. Trends in Cardiovascular Medicine. 4: 243-50. PMID 21244874 DOI: 10.1016/1050-1738(94)90027-2 |
0.569 |
|
| 2012 |
Caldwell JT, Melkani GC, Huxford T, Bernstein SI. A Method for the Transgenic Expression and Purification of Skeletal Muscle Myosin II Isoforms using Drosophila Melanogaster Biophysical Journal. 102: 149a. DOI: 10.1016/J.Bpj.2011.11.813 |
0.813 |
|
| 2012 |
Bloemink MJ, Melkani GC, Geeves MA, Bernstein SI. Kinetic Characterization of Converter and Relay Loop Domain Interaction in Drosophila Myosin Sub-Fragment 1 Biophysical Journal. 102: 149a. DOI: 10.1016/J.Bpj.2011.11.812 |
0.394 |
|
| 2012 |
Melkani GC, Kronert WA, Melkani A, Bernstein SI. Interaction Between the Relay Loop and the SH1-SH2 Helix Region in Drosophila Muscle Myosin is Essential for Normal Motor Function, Myofibril Stability and Muscle Contraction Biophysical Journal. 102: 148a-149a. DOI: 10.1016/J.Bpj.2011.11.811 |
0.604 |
|
| 2012 |
Melkani GC, Bodmer R, Ocorr K, Bernstein SI. Exploration and Suppression of Cardiac Amyloidosis Induced by Huntington's Disease-Causing Amyloid in the Drosophila Heart Model Biophysical Journal. 102: 351a. DOI: 10.1016/J.Bpj.2011.11.1923 |
0.33 |
|
| 2012 |
Viswanathan M, Kronert W, Melkani G, Bernstein SI. Myosin Storage Myopathy Mutations Cause Age Dependent Muscle Degeneration and Cardiac Dysfunction in a Drosophila Model Biophysical Journal. 102: 253a-254a. DOI: 10.1016/J.Bpj.2011.11.1398 |
0.558 |
|
| 2011 |
Cammarato A, Li XE, Reedy MC, Lee CF, Lehman W, Bernstein SI. Structural basis for myopathic defects engendered by alterations in the myosin rod. Journal of Molecular Biology. 414: 477-84. PMID 22037585 DOI: 10.1016/J.Jmb.2011.10.019 |
0.412 |
|
| 2011 |
Ramanath S, Wang Q, Bernstein SI, Swank DM. Disrupting the myosin converter-relay interface impairs Drosophila indirect flight muscle performance. Biophysical Journal. 101: 1114-22. PMID 21889448 DOI: 10.1016/J.Bpj.2011.07.045 |
0.542 |
|
| 2011 |
Melkani GC, Bodmer R, Ocorr K, Bernstein SI. The UNC-45 chaperone is critical for establishing myosin-based myofibrillar organization and cardiac contractility in the Drosophila heart model. Plos One. 6: e22579. PMID 21799905 DOI: 10.1371/Journal.Pone.0022579 |
0.38 |
|
| 2011 |
Bloemink MJ, Melkani GC, Dambacher CM, Bernstein SI, Geeves MA. Two Drosophila myosin transducer mutants with distinct cardiomyopathies have divergent ADP and actin affinities. The Journal of Biological Chemistry. 286: 28435-43. PMID 21680742 DOI: 10.1074/Jbc.M111.258228 |
0.459 |
|
| 2011 |
Cammarato A, Ahrens CH, Alayari NN, Qeli E, Rucker J, Reedy MC, Zmasek CM, Gucek M, Cole RN, Van Eyk JE, Bodmer R, O'Rourke B, Bernstein SI, Foster DB. A mighty small heart: the cardiac proteome of adult Drosophila melanogaster. Plos One. 6: e18497. PMID 21541028 DOI: 10.1371/Journal.Pone.0018497 |
0.324 |
|
| 2011 |
Lee CF, Hauenstein AV, Fleming JK, Gasper WC, Engelke V, Sankaran B, Bernstein SI, Huxford T. X-ray crystal structure of the UCS domain-containing UNC-45 myosin chaperone from Drosophila melanogaster. Structure (London, England : 1993). 19: 397-408. PMID 21397190 DOI: 10.1016/J.Str.2011.01.002 |
0.71 |
|
| 2011 |
Lee CF, Melkani GC, Yu Q, Suggs JA, Kronert WA, Suzuki Y, Hipolito L, Price MG, Epstein HF, Bernstein SI. Drosophila UNC-45 accumulates in embryonic blastoderm and in muscles, and is essential for muscle myosin stability. Journal of Cell Science. 124: 699-705. PMID 21285246 DOI: 10.1242/Dev.065722 |
0.629 |
|
| 2011 |
Cammarato A, Wang Y, Melkani A, Melkani GC, Bialobrodski A, Suggs JA, Kronert WA, Bernstein SI. The E706K IBM3 Myosin Mutation Depresses the Chemomechanical Properties and Increases the Lability of the Molecular Motor Biophysical Journal. 100: 129a. DOI: 10.1016/J.Bpj.2010.12.909 |
0.536 |
|
| 2011 |
Melkani GC, Ocorr K, Bodmer R, Bernstein SI. Drosophila as a Model for Amyloid Induced Cardiac Dysfunction Biophysical Journal. 100: 294a. DOI: 10.1016/J.Bpj.2010.12.1806 |
0.343 |
|
| 2010 |
Melkani GC, Lee CF, Cammarato A, Bernstein SI. Drosophila UNC-45 prevents heat-induced aggregation of skeletal muscle myosin and facilitates refolding of citrate synthase. Biochemical and Biophysical Research Communications. 396: 317-22. PMID 20403336 DOI: 10.1016/J.Bbrc.2010.04.090 |
0.575 |
|
| 2010 |
Kronert WA, Melkani GC, Melkani A, Bernstein SI. Mutating the converter-relay interface of Drosophila myosin perturbs ATPase activity, actin motility, myofibril stability and flight ability. Journal of Molecular Biology. 398: 625-32. PMID 20362584 DOI: 10.1016/J.Jmb.2010.03.049 |
0.554 |
|
| 2010 |
Wang Y, Kronert WA, Melkani GC, Melkani A, Bernstein S. A Single Amino Acid Mutation in the Drosophila Myosin SH1 Domain Severely Affects Muscle Function, Myofibril Structure, Myosin Enzymatic Activity, and Actin Sliding Velocity Biophysical Journal. 98: 144a. DOI: 10.1016/J.Bpj.2009.12.774 |
0.615 |
|
| 2010 |
Cammarato A, Alayari NN, Gucek M, Reedy MC, Rucker J, Van Eyk JE, Cole RN, O'Rourke B, Bodmer R, Bernstein SI, Foster DB. A Systems Biology Approach to Restrictive Cardiomyopathy in Drosophila Biophysical Journal. 98: 717a-718a. DOI: 10.1016/J.Bpj.2009.12.3933 |
0.429 |
|
| 2010 |
Corcione MM, Zhao C, Kronert WA, Bernstein SI, Swank DM. Myosin-Based Inclusion Body Myopathy Type 3 Decreases Muscle Power Generation and Kinetics Biophysical Journal. 98: 544a. DOI: 10.1016/J.Bpj.2009.12.2950 |
0.558 |
|
| 2010 |
Cammarato A, Li X, Reedy MC, Lee C, Li P, Lehman W, Bernstein SI. Transgenic Replacement of the Myosin S2/hmm Hinge Alters the Rod's Nano-Mechanical Properties and Affects Sarcomeric Organization Biophysical Journal. 98: 543a. DOI: 10.1016/J.Bpj.2009.12.2946 |
0.519 |
|
| 2010 |
Lee CF, Hauenstein AV, Gasper WC, Sankaran B, Bernstein SI, Huxford T. Crystal Structure of Drosophila Unc-45, a Putative Myosin Chaperone Biophysical Journal. 98: 34a. DOI: 10.1016/J.Bpj.2009.12.199 |
0.712 |
|
| 2010 |
Melkani GC, Kronert WA, Melkani A, Bernstein SI. Converter Domain Residue R759 Interaction with Relay Loop Residue N509 in Drosophila Muscle Myosin is Critical for Motor Function, Myofibril Stability and Flight Ability Biophysical Journal. 98: 215a. DOI: 10.1016/J.Bpj.2009.12.1162 |
0.487 |
|
| 2010 |
Melkani GC, Ocorr K, Bodmer R, Bernstein SI. UNC-45 Knock-Down in Drosophila Heart Targets Myosin Accumulation and Yields Severe Myofibrillar Disarray and Cardiac Dysfunction Biophysical Journal. 98: 7a. DOI: 10.1016/J.Bpj.2009.12.041 |
0.383 |
|
| 2009 |
Miller MS, Dambacher CM, Knowles AF, Braddock JM, Farman GP, Irving TC, Swank DM, Bernstein SI, Maughan DW. Alternative S2 hinge regions of the myosin rod affect myofibrillar structure and myosin kinetics. Biophysical Journal. 96: 4132-43. PMID 19450484 DOI: 10.1016/J.Bpj.2009.02.034 |
0.561 |
|
| 2009 |
Bloemink MJ, Dambacher CM, Knowles AF, Melkani GC, Geeves MA, Bernstein SI. Alternative exon 9-encoded relay domains affect more than one communication pathway in the Drosophila myosin head. Journal of Molecular Biology. 389: 707-21. PMID 19393244 DOI: 10.1016/J.Jmb.2009.04.036 |
0.422 |
|
| 2009 |
Bernstein S. An Integrative Analysis of the Muscle Myosin Motor Using Genetic and Transgenic Tools Biophysical Journal. 96: 554a. DOI: 10.1016/J.Bpj.2008.12.3639 |
0.646 |
|
| 2009 |
Cammarato A, Alayari NN, Ocorr K, Bodmer R, Bernstein SI. Polygenic Modulation of Cardiac Dysfunction in Drosophila Assessed by High-speed Video Imaging, Motion Detection Analysis and Fluorescent Microscopy Biophysical Journal. 96: 622a. DOI: 10.1016/J.Bpj.2008.12.3288 |
0.362 |
|
| 2009 |
Alayari NN, Cammarato A, Reedy MC, O'Rourke B, Van Eyk J, Rucker J, Bodmer R, Bernstein SI, Foster DB. Structural and Proteomic Analysis of the Drosophila Cardiac Tube Biophysical Journal. 96: 502a. DOI: 10.1016/J.Bpj.2008.12.2590 |
0.386 |
|
| 2009 |
Bloemink MJ, Dambacher CM, Melkani G, Geeves M, Bernstein SI. Kinetics Of Two Single Point Mutants Of Drosophila Myosin S1 Biophysical Journal. 96: 496a-497a. DOI: 10.1016/J.Bpj.2008.12.2563 |
0.458 |
|
| 2009 |
Ramanath S, Wang Q, Kronert WA, Bernstein S, Swank DM. Disrupting Myosin Relay-Converter Domain Communication Impairs Drosophila Muscle Mechanical Performance and Flight Ability Biophysical Journal. 96: 212a-213a. DOI: 10.1016/J.Bpj.2008.12.1876 |
0.471 |
|
| 2008 |
Bernstein SI, Geeves MA. The XXXVII European muscle conference: Oxford September 2008. Journal of Muscle Research and Cell Motility. 29: 253-6. PMID 19034677 DOI: 10.1007/S10974-008-9151-Z |
0.559 |
|
| 2008 |
Yang C, Ramanath S, Kronert WA, Bernstein SI, Maughan DW, Swank DM. Alternative versions of the myosin relay domain differentially respond to load to influence Drosophila muscle kinetics. Biophysical Journal. 95: 5228-37. PMID 18805920 DOI: 10.1529/Biophysj.108.136192 |
0.569 |
|
| 2008 |
Littlefield KP, Ward AB, Chappie JS, Reedy MK, Bernstein SI, Milligan RA, Reedy MC. Similarities and differences between frozen-hydrated, rigor acto-S1 complexes of insect flight and chicken skeletal muscles. Journal of Molecular Biology. 381: 519-28. PMID 18588896 DOI: 10.1016/J.Jmb.2008.06.029 |
0.582 |
|
| 2008 |
Kronert WA, Dambacher CM, Knowles AF, Swank DM, Bernstein SI. Alternative relay domains of Drosophila melanogaster myosin differentially affect ATPase activity, in vitro motility, myofibril structure and muscle function. Journal of Molecular Biology. 379: 443-56. PMID 18462751 DOI: 10.1016/J.Jmb.2008.04.010 |
0.523 |
|
| 2008 |
Cammarato A, Dambacher CM, Knowles AF, Kronert WA, Bodmer R, Ocorr K, Bernstein SI. Myosin transducer mutations differentially affect motor function, myofibril structure, and the performance of skeletal and cardiac muscles. Molecular Biology of the Cell. 19: 553-62. PMID 18045988 DOI: 10.1091/Mbc.E07-09-0890 |
0.605 |
|
| 2007 |
Miller BM, Bloemink MJ, Nyitrai M, Bernstein SI, Geeves MA. A variable domain near the ATP-binding site in Drosophila muscle myosin is part of the communication pathway between the nucleotide and actin-binding sites. Journal of Molecular Biology. 368: 1051-66. PMID 17379245 DOI: 10.1016/J.Jmb.2007.02.042 |
0.538 |
|
| 2007 |
Suggs JA, Cammarato A, Kronert WA, Nikkhoy M, Dambacher CM, Megighian A, Bernstein SI. Alternative S2 Hinge Regions of the Myosin Rod Differentially Affect Muscle Function, Myofibril Dimensions and Myosin Tail Length Journal of Molecular Biology. 367: 1312-1329. PMID 17316684 DOI: 10.1016/J.Jmb.2007.01.045 |
0.614 |
|
| 2007 |
Hess NK, Singer PA, Trinh K, Nikkhoy M, Bernstein SI. Transcriptional regulation of the Drosophila melanogaster muscle myosin heavy-chain gene. Gene Expression Patterns : Gep. 7: 413-22. PMID 17194628 DOI: 10.1016/J.Modgep.2006.11.007 |
0.593 |
|
| 2007 |
Swank D, Bernstein S, Maughan D. 35.3. Myosin structural regions that determine mechanical differences between Drosophila muscle fiber types Comparative Biochemistry and Physiology Part a: Molecular & Integrative Physiology. 148: S149-S150. DOI: 10.1016/J.Cbpa.2007.06.379 |
0.407 |
|
| 2006 |
Hao Y, Miller MS, Swank DM, Liu H, Bernstein SI, Maughan DW, Pollack GH. Passive stiffness in Drosophila indirect flight muscle reduced by disrupting paramyosin phosphorylation, but not by embryonic myosin S2 hinge substitution. Biophysical Journal. 91: 4500-6. PMID 17012313 DOI: 10.1529/Biophysj.106.088492 |
0.506 |
|
| 2006 |
Melkani GC, Cammarato A, Bernstein SI. alphaB-crystallin maintains skeletal muscle myosin enzymatic activity and prevents its aggregation under heat-shock stress. Journal of Molecular Biology. 358: 635-45. PMID 16546210 DOI: 10.1016/J.Jmb.2006.02.043 |
0.407 |
|
| 2006 |
Swank DM, Braddock J, Brown W, Lesage H, Bernstein SI, Maughan DW. An alternative domain near the ATP binding pocket of Drosophila myosin affects muscle fiber kinetics. Biophysical Journal. 90: 2427-35. PMID 16399836 DOI: 10.1529/Biophysj.105.075184 |
0.539 |
|
| 2005 |
Miller BM, Zhang S, Suggs JA, Swank DM, Littlefield KP, Knowles AF, Bernstein SI. An alternative domain near the nucleotide-binding site of Drosophila muscle myosin affects ATPase kinetics. Journal of Molecular Biology. 353: 14-25. PMID 16154586 DOI: 10.1016/J.Jmb.2005.08.012 |
0.65 |
|
| 2005 |
Liu H, Miller MS, Swank DM, Kronert WA, Maughan DW, Bernstein SI. Paramyosin phosphorylation site disruption affects indirect flight muscle stiffness and power generation in Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. 102: 10522-7. PMID 16020538 DOI: 10.1073/Pnas.0500945102 |
0.575 |
|
| 2004 |
Hao Y, Bernstein SI, Pollack GH. Passive stiffness of Drosophila IFM myofibrils: a novel, high accuracy measurement method. Journal of Muscle Research and Cell Motility. 25: 359-66. PMID 15548865 DOI: 10.1007/S10974-004-0684-5 |
0.529 |
|
| 2004 |
Swank DM, Kronert WA, Bernstein SI, Maughan DW. Alternative N-terminal regions of Drosophila myosin heavy chain tune muscle kinetics for optimal power output. Biophysical Journal. 87: 1805-14. PMID 15345559 DOI: 10.1529/Biophysj.103.032078 |
0.574 |
|
| 2003 |
Miller BM, Nyitrai M, Bernstein SI, Geeves MA. Kinetic analysis of Drosophila muscle myosin isoforms suggests a novel mode of mechanochemical coupling. The Journal of Biological Chemistry. 278: 50293-300. PMID 14506231 DOI: 10.1074/Jbc.M308318200 |
0.598 |
|
| 2003 |
Yu Q, Bernstein SI. UCS proteins: managing the myosin motor. Current Biology : Cb. 13: R525-7. PMID 12842031 DOI: 10.1016/S0960-9822(03)00447-0 |
0.364 |
|
| 2003 |
Liu H, Mardahl-Dumesnil M, Sweeney ST, O'Kane CJ, Bernstein SI. Drosophila paramyosin is important for myoblast fusion and essential for myofibril formation. The Journal of Cell Biology. 160: 899-908. PMID 12642615 DOI: 10.1083/Jcb.200208180 |
0.592 |
|
| 2003 |
Swank DM, Knowles AF, Kronert WA, Suggs JA, Morrill GE, Nikkhoy M, Manipon GG, Bernstein SI. Variable N-terminal regions of muscle myosin heavy chain modulate ATPase rate and actin sliding velocity. The Journal of Biological Chemistry. 278: 17475-82. PMID 12606545 DOI: 10.1074/Jbc.M212727200 |
0.635 |
|
| 2003 |
Littlefield KP, Swank DM, Sanchez BM, Knowles AF, Warshaw DM, Bernstein SI. The converter domain modulates kinetic properties of Drosophila myosin. American Journal of Physiology. Cell Physiology. 284: C1031-8. PMID 12477668 DOI: 10.1152/Ajpcell.00474.2002 |
0.501 |
|
| 2002 |
Swank DM, Knowles AF, Suggs JA, Sarsoza F, Lee A, Maughan DW, Bernstein SI. The myosin converter domain modulates muscle performance. Nature Cell Biology. 4: 312-6. PMID 11901423 DOI: 10.1038/Ncb776 |
0.623 |
|
| 2001 |
Arredondo JJ, Mardahl-Dumesnil M, Cripps RM, Cervera M, Bernstein SI. Overexpression of miniparamyosin causes muscle dysfunction and age-dependant myofibril degeneration in the indirect flight muscles of Drosophila melanogaster Journal of Muscle Research and Cell Motility. 22: 287-299. PMID 11763201 DOI: 10.1023/A:1012431725009 |
0.608 |
|
| 2001 |
Zhang S, Bernstein SI. Spatially and temporally regulated expression of myosin heavy chain alternative exons during Drosophila embryogenesis. Mechanisms of Development. 101: 35-45. PMID 11231057 DOI: 10.1016/S0925-4773(00)00549-9 |
0.612 |
|
| 2001 |
Swank DM, Bartoo ML, Knowles AF, Iliffe C, Bernstein SI, Molloy JE, Sparrow JC. Alternative exon-encoded regions of Drosophila myosin heavy chain modulate ATPase rates and actin sliding velocity. The Journal of Biological Chemistry. 276: 15117-24. PMID 11134017 DOI: 10.1074/Jbc.M008379200 |
0.637 |
|
| 2001 |
Arredondo JJ, Marco Ferreres R, Maroto M, Cripps RM, Marco R, Bernstein SI, Cervera M. Control of Drosophila paramyosin/miniparamyosin gene expression. Differential regulatory mechanisms for muscle-specific transcription Journal of Biological Chemistry. 276: 8278-8287. PMID 11110792 DOI: 10.1074/Jbc.M009302200 |
0.479 |
|
| 2000 |
Swank DM, Wells L, Kronert WA, Morrill GE, Bernstein SI. Determining structure/function relationships for sarcomeric myosin heavy chain by genetic and transgenic manipulation of Drosophila. Microscopy Research and Technique. 50: 430-42. PMID 10998634 DOI: 10.1002/1097-0029(20000915)50:6<430::Aid-Jemt2>3.0.Co;2-E |
0.63 |
|
| 1999 |
Cripps RM, Suggs JA, Bernstein SI. Assembly of thick filaments and myofibrils occurs in the absence of the myosin head Embo Journal. 18: 1793-1804. PMID 10202143 DOI: 10.1093/Emboj/18.7.1793 |
0.553 |
|
| 1999 |
Kronert WA, Acebes A, Ferrús A, Bernstein SI. Specific myosin heavy chain mutations suppress troponin I defects in Drosophila muscles. The Journal of Cell Biology. 144: 989-1000. PMID 10085296 DOI: 10.1083/Jcb.144.5.989 |
0.508 |
|
| 1997 |
Bernstein SI, Milligan RA. Fine tuning a molecular motor: the location of alternative domains in the Drosophila myosin head. Journal of Molecular Biology. 271: 1-6. PMID 9300050 DOI: 10.1006/Jmbi.1997.1160 |
0.603 |
|
| 1996 |
Wells L, Edwards KA, Bernstein SI. Myosin heavy chain isoforms regulate muscle function but not myofibril assembly. The Embo Journal. 15: 4454-4459. DOI: 10.1002/J.1460-2075.1996.Tb00822.X |
0.628 |
|
| 1995 |
Kronert WA, O'Donnell PT, Fieck A, Lawn A, Vigoreaux JO, Sparrow JC, Bernstein SI. Defects in the Drosophila myosin rod permit sarcomere assembly but cause flight muscle degeneration. Journal of Molecular Biology. 249: 111-25. PMID 7776366 DOI: 10.1006/Jmbi.1995.0283 |
0.609 |
|
| 1994 |
Kronert WA, O'Donnell PT, Bernstein SI. A charge change in an evolutionarily-conserved region of the myosin globular head prevents myosin and thick filament accumulation in Drosophila. Journal of Molecular Biology. 236: 697-702. PMID 8114087 DOI: 10.1006/Jmbi.1994.1182 |
0.595 |
|
| 1994 |
Cripps RM, Becker KD, Mardahl M, Kronert WA, Hodges D, Bernstein SI. Transformation of Drosophila melanogaster with the wild-type myosin heavy-chain gene: Rescue of mutant phenotypes and analysis of defects caused by overexpression Journal of Cell Biology. 126: 689-699. PMID 8045933 DOI: 10.1083/Jcb.126.3.689 |
0.587 |
|
| 1994 |
Fyrberg EA, Bernstein SI, VijayRaghavan K. Basic methods for Drosophila muscle biology. Methods in Cell Biology. 44: 237-58. PMID 7707955 DOI: 10.1016/S0091-679X(08)60917-6 |
0.578 |
|
| 1993 |
Bernstein SI, O'Donnell PT, Cripps RM. Molecular genetic analysis of muscle development, structure, and function in Drosophila International Review of Cytology. 143: 63-152. PMID 8449665 DOI: 10.1016/S0074-7696(08)61874-4 |
0.567 |
|
| 1992 |
Becker KD, O'Donnell PT, Heitz JM, Vito M, Bernstein SI. Analysis of Drosophila paramyosin: identification of a novel isoform which is restricted to a subset of adult muscles. The Journal of Cell Biology. 116: 669-81. PMID 1730773 DOI: 10.1083/Jcb.116.3.669 |
0.557 |
|
| 1992 |
Hodges D, Bernstein SI. Suboptimal 5' and 3' splice sites regulate alternative splicing of Drosophila melanogaster myosin heavy chain transcripts in vitro. Mechanisms of Development. 37: 127-40. PMID 1498040 DOI: 10.1016/0925-4773(92)90075-U |
0.462 |
|
| 1992 |
Epstein HF, Bernstein SI. Genetic approaches to understanding muscle development. Developmental Biology. 154: 231-44. PMID 1426637 DOI: 10.1016/0012-1606(92)90064-N |
0.566 |
|
| 1991 |
Hess NK, Bernstein SI. Developmentally regulated alternative splicing of Drosophila myosin heavy chain transcripts: in vivo analysis of an unusual 3' splice site. Developmental Biology. 146: 339-44. PMID 1907580 DOI: 10.1016/0012-1606(91)90235-U |
0.471 |
|
| 1991 |
Kronert W, Edwards K, Roche E, Wells L, Bernstein S. Muscle-specific accumulation of Drosophila myosin heavy chains: a splicing mutation in an alternative exon results in an isoform substitution. The Embo Journal. 10: 2479-2488. DOI: 10.1002/J.1460-2075.1991.Tb07787.X |
0.595 |
|
| 1990 |
Collier VL, Kronert WA, O'Donnell PT, Edwards KA, Bernstein SI. Alternative myosin hinge regions are utilized in a tissue-specific fashion that correlates with muscle contraction speed. Genes & Development. 4: 885-95. PMID 2116987 DOI: 10.1101/Gad.4.6.885 |
0.531 |
|
| 1989 |
O'Donnell PT, Collier VL, Mogami K, Bernstein SI. Ultrastructural and molecular analyses of homozygous-viable Drosophila melanogaster muscle mutants indicate there is a complex pattern of myosin heavy-chain isoform distribution. Genes & Development. 3: 1233-46. PMID 2477306 DOI: 10.1101/Gad.3.8.1233 |
0.624 |
|
| 1989 |
O'Donnell PT, Bernstein SI. Molecular and ultrastructural defects in a Drosophila myosin heavy chain mutant: differential effects on muscle function produced by similar thick filament abnormalities. The Journal of Cell Biology. 107: 2601-12. PMID 2462566 DOI: 10.1083/Jcb.107.6.2601 |
0.624 |
|
| 1987 |
Emerson CP, Bernstein SI. Molecular genetics of myosin. Annual Review of Biochemistry. 56: 695-726. PMID 3304146 DOI: 10.1146/Annurev.Bi.56.070187.003403 |
0.477 |
|
| 1986 |
Mogami K, O'Donnell PT, Bernstein SI, Wright TR, Emerson CP. Mutations of the Drosophila myosin heavy-chain gene: effects on transcription, myosin accumulation, and muscle function. Proceedings of the National Academy of Sciences of the United States of America. 83: 1393-7. PMID 3006049 DOI: 10.1073/Pnas.83.5.1393 |
0.587 |
|
| 1986 |
Bernstein SI, Hansen CJ, Becker KD, Wassenberg DR, Roche ES, Donady JJ, Emerson CP. Alternative RNA splicing generates transcripts encoding a thorax-specific isoform of Drosophila melanogaster myosin heavy chain. Molecular and Cellular Biology. 6: 2511-9. PMID 2431291 DOI: 10.1128/Mcb.6.7.2511 |
0.536 |
|
| 1983 |
Bernstein SI, Mogami K, Donady JJ, Emerson CP. Drosophila muscle myosin heavy chain encoded by a single gene in a cluster of muscle mutations. Nature. 302: 393-7. PMID 6403869 DOI: 10.1038/302393A0 |
0.541 |
|
| 1981 |
Bernstein SI, Donady JJ. RNA synthesis and coding capacity of polyadenylated and nonpolyadenylated mRNA from cultures of differentiating Drosophila melanogaster myoblasts. Developmental Biology. 79: 388-98. PMID 6775993 DOI: 10.1016/0012-1606(80)90124-4 |
0.382 |
|
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