We are testing a new system for linking grants to scientists.
The funding information displayed below comes from the
NIH Research Portfolio Online Reporting Tools and the
NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please
sign in and mark grants as correct or incorrect matches.
Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.
High-probability grants
According to our matching algorithm, Rong Mao is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2010 — 2011 |
Mao, Rong |
K99Activity Code Description: To support the initial phase of a Career/Research Transition award program that provides 1-2 years of mentored support for highly motivated, advanced postdoctoral research scientists. |
Synaptic Deficits of Ips Cell-Derived Neurons From Patients With Autism
DESCRIPTION (provided by applicant): Synaptic deficits of iPS cell-derived neurons from patients with autism The goal of this proposal is to examine the physiological properties and synaptic function of ASD patient- specific neurons generated from induced pluripotent stem (iPS) cells. Many lines of evidence suggest genetic etiologies for Autism Spectrum Disorders (ASDs), but little is known about the cellular/physiological ramifications of these genetic defects. Thus, to probe the cellular basis underlying autism phenotypes, I will differentiate iPS cells from genetically defined ASD patients into neurons, and apply a combination of cutting- edge techniques including in vitro whole-cell and slide recordings, calcium imaging, and gene transfer to characterize these iPS-derived neurons. Specifically, I will study iPS cell-derived neurons from patients with point mutations or deletions in SHANK3. This gene has a key role in calcium channel function and synapse formation. I will test the hypothesis that genetic alternations in SHANK3 cause defects in the intrinsic properties and synaptic function of iPS-derived neurons from these patients. I will thoroughly investigate neuronal properties of these cell lines to provide a possible mechanistic link between the genetic alterations in the patients and their behavioral phenotypes. I will also test therapeutic strategies by using viral-mediated gene transduction to rescue neuronal phenotypes. PUBLIC HEALTH RELEVANCE Synaptic deficits of iPS cell-derived neurons from patients with autism The goal of this project is to identify biological phenotypes of neurons derived from induced pluripotent stem (iPS) cells from individuals with autism and defined genetic alterations in the SHANK3 gene. These experiments will contribute to our understanding of mechanisms underlying autism and may lead to advances in identifying new therapeutic targets and treatment strategies. They will also lay the foundation for the development of a cell-based assay system to study iPS cells and neurons from patients with a broad set of autistic spectrum disorders. PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page 1 Continuation Format Page
|
1 |