| Year |
Citation |
Score |
| 2020 |
de Conti A, Tryndyak V, Heidor R, Jimenez L, Moreno FS, Beland FA, Rusyn I, Pogribny IP. Butyrate-containing structured lipids inhibit RAC1 and epithelial-to-mesenchymal transition markers: A chemopreventive mechanism against hepatocarcinogenesis. The Journal of Nutritional Biochemistry. 108496. PMID 32920087 DOI: 10.1016/J.Jnutbio.2020.108496 |
0.307 |
|
| 2020 |
Chen Z, Liu Y, Wright FA, Chiu WA, Rusyn I. Rapid hazard characterization of environmental chemicals using a compendium of human cell lines from different organs. Altex. PMID 32521033 DOI: 10.14573/Altex.2002291 |
0.344 |
|
| 2020 |
Dalaijamts C, Cichocki JA, Luo YS, Rusyn I, Chiu WA. PBPK modeling of impact of nonalcoholic fatty liver disease on toxicokinetics of perchloroethylene in mice. Toxicology and Applied Pharmacology. 115069. PMID 32445755 DOI: 10.1016/J.Taap.2020.115069 |
0.347 |
|
| 2020 |
de Conti A, Tryndyak V, Willett RA, Borowa-Mazgaj B, Watson A, Patton R, Khare S, Muskhelishvili L, Olson GR, Avigan MI, Cerniglia CE, Ross SA, Sanyal AJ, Beland FA, Rusyn I, et al. Characterization of the variability in the extent of nonalcoholic fatty liver induced by a high-fat diet in the genetically diverse Collaborative Cross mouse model. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 32304142 DOI: 10.1096/Fj.202000194R |
0.35 |
|
| 2020 |
Keele GR, Quach BC, Israel JW, Chappell GA, Lewis L, Safi A, Simon JM, Cotney P, Crawford GE, Valdar W, Rusyn I, Furey TS. Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation. Plos Genetics. 16: e1008537. PMID 31961859 DOI: 10.1371/Journal.Pgen.1008537 |
0.324 |
|
| 2020 |
Hyun J, Sun Z, Ahmadi AR, Bangru S, Chembazhi UV, Du K, Chen T, Tsukamoto H, Rusyn I, Kalsotra A, Diehl AM. Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis. The Journal of Clinical Investigation. PMID 31945016 DOI: 10.1172/Jci132691 |
0.351 |
|
| 2019 |
Furuya S, Argemi J, Uehara T, Katou Y, Fouts DE, Schnabl B, Dubuquoy L, Belorkar A, Vadigepalli R, Kono H, Bataller R, Rusyn I. A novel mouse model of acute-on-chronic cholestatic alcoholic liver disease: A systems biology comparison with human alcoholic hepatitis. Alcoholism, Clinical and Experimental Research. PMID 31710124 DOI: 10.1111/Acer.14234 |
0.334 |
|
| 2019 |
Burnett SD, Blanchette AD, Grimm FA, House JS, Reif DM, Wright FA, Chiu WA, Rusyn I. Population-based toxicity screening in human induced pluripotent stem cell-derived cardiomyocytes. Toxicology and Applied Pharmacology. 114711. PMID 31425687 DOI: 10.1016/J.Taap.2019.114711 |
0.351 |
|
| 2019 |
Argemi J, Latasa MU, Atkinson SR, Blokhin IO, Massey V, Gue JP, Cabezas J, Lozano JJ, Van Booven D, Bell A, Cao S, Vernetti LA, Arab JP, Ventura-Cots M, Edmunds LR, ... ... Rusyn I, et al. Defective HNF4alpha-dependent gene expression as a driver of hepatocellular failure in alcoholic hepatitis. Nature Communications. 10: 3126. PMID 31311938 DOI: 10.1038/S41467-019-11004-3 |
0.382 |
|
| 2019 |
Borowa-Mazgaj B, de Conti A, Tryndyak V, Steward CR, Jimenez L, Melnyk S, Seneshaw M, Mirshahi F, Rusyn I, Beland FA, Sanyal AJ, Pogribny IP. Gene expression and DNA methylation alterations in the glycine N-methyltransferase gene in diet-induced nonalcoholic fatty liver disease-associated carcinogenesis. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 31086990 DOI: 10.1093/Toxsci/Kfz110 |
0.376 |
|
| 2019 |
Lewis L, Borowa-Mazgaj B, de Conti A, Chappell GA, Luo YS, Bodnar W, Konganti K, Wright FA, Threadgill DW, Chiu WA, Pogribny IP, Rusyn I. Population-based analysis of DNA damage and epigenetic effects of 1,3-butadiene in the mouse. Chemical Research in Toxicology. PMID 30990016 DOI: 10.1021/Acs.Chemrestox.9B00035 |
0.359 |
|
| 2019 |
Perry A, Lynch RM, Rusyn I, Threadgill DW. Long-Term Combinatorial Exposure to Trichloroethylene and Inorganic Arsenic in Genetically Heterogeneous Mice Results in Renal Tubular Damage and Cancer-Associated Molecular Changes. G3 (Bethesda, Md.). PMID 30898898 DOI: 10.1534/G3.119.400161 |
0.326 |
|
| 2018 |
Lewis L, Chappell GA, Kobets T, O'Brian BE, Sangaraju D, Kosyk O, Bodnar W, Tretyakova NY, Pogribny IP, Rusyn I. Sex-specific differences in genotoxic and epigenetic effects of 1,3-butadiene among mouse tissues. Archives of Toxicology. PMID 30552462 DOI: 10.1007/S00204-018-2374-X |
0.341 |
|
| 2018 |
Furuya S, Cichocki JA, Konganti K, Dreval K, Uehara T, Katou Y, Fukushima H, Kono H, Pogribny IP, Argemi J, Bataller R, Rusyn I. Histopathological and molecular signatures of a mouse model of acute-on-chronic alcoholic liver injury demonstrate concordance with human alcoholic hepatitis. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30517762 DOI: 10.1093/Toxsci/Kfy292 |
0.369 |
|
| 2018 |
Grimm FA, House JS, Wilson MR, Sirenko O, Iwata Y, Wright FA, Ball N, Rusyn I. Multi-dimensional in vitro bioactivity profiling for grouping of glycol ethers. Regulatory Toxicology and Pharmacology : Rtp. PMID 30471335 DOI: 10.1016/J.Yrtph.2018.11.011 |
0.356 |
|
| 2018 |
Low Y, Alves VM, Fourches D, Sedykh A, Andrade CH, Muratov EN, Rusyn I, Tropsha A. Chemistry-Wide Association Studies (CWAS): A Novel Framework for Identifying and Interpreting Structure-Activity Relationships. Journal of Chemical Information and Modeling. PMID 30376324 DOI: 10.1021/Acs.Jcim.8B00450 |
0.719 |
|
| 2018 |
Blanchette AD, Grimm FA, Dalaijamts C, Hsieh NH, Ferguson K, Luo YS, Rusyn I, Chiu WA. Thorough QT/QTc in a Dish: An In Vitro Human Model That Accurately Predicts Clinical Concentration-QTc Relationships. Clinical Pharmacology and Therapeutics. PMID 30346629 DOI: 10.1002/Cpt.1259 |
0.305 |
|
| 2018 |
Cichocki JA, Luo YS, Furuya S, Venkatratnam A, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I. Modulation of tetrachloroethylene-associated kidney effects by nonalcoholic fatty liver or steatohepatitis in male C57BL/6J mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 30202895 DOI: 10.1093/Toxsci/Kfy223 |
0.352 |
|
| 2018 |
Luo YS, Hsieh NH, Soldatow VY, Chiu WA, Rusyn I. Comparative Analysis of Metabolism of Trichloroethylene and Tetrachloroethylene among Mouse Tissues and Strains. Toxicology. PMID 30053492 DOI: 10.1016/J.Tox.2018.07.012 |
0.349 |
|
| 2018 |
Grimm FA, Blanchette A, House JS, Ferguson K, Hsieh NH, Dalaijamts C, Wright AA, Anson B, Wright FA, Chiu WA, Rusyn I. A human population-based organotypic in vitro model for cardiotoxicity screening. Altex. PMID 29999168 DOI: 10.14573/Altex.1805301 |
0.322 |
|
| 2018 |
Luo YS, Furuya S, Soldatov VY, Kosyk O, Yoo HS, Fukushima H, Lewis L, Iwata Y, Rusyn I. Metabolism and Toxicity of Trichloroethylene and Tetrachloroethylene in Cytochrome P450 2E1 Knockout and Humanized Transgenic Mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 29897530 DOI: 10.1093/Toxsci/Kfy099 |
0.67 |
|
| 2018 |
Dalaijamts C, Cichocki JA, Luo YS, Rusyn I, Chiu WA. Incorporation of the glutathione conjugation pathway in an updated physiologically-based pharmacokinetic model for perchloroethylene in mice. Toxicology and Applied Pharmacology. PMID 29857080 DOI: 10.1016/J.Taap.2018.05.033 |
0.34 |
|
| 2018 |
Guyton KZ, Rusyn I, Chiu WA, Corpet DE, van den Berg M, Ross MK, Christiani DC, Beland FA, Smith MT. Application of the key characteristics of carcinogens in cancer hazard identification. Carcinogenesis. PMID 29562322 DOI: 10.1093/Carcin/Bgy031 |
0.306 |
|
| 2018 |
Israel JW, Chappell GA, Simon JM, Pott S, Safi A, Lewis L, Cotney P, Boulos HS, Bodnar W, Lieb JD, Crawford GE, Furey TS, Rusyn I. Tissue- and strain-specific effects of a genotoxic carcinogen 1,3-butadiene on chromatin and transcription. Mammalian Genome : Official Journal of the International Mammalian Genome Society. PMID 29429127 DOI: 10.1007/S00335-018-9739-6 |
0.347 |
|
| 2018 |
Venkatratnam A, House JS, Konganti K, McKenney C, Threadgill DW, Chiu WA, Aylor DL, Wright FA, Rusyn I. Population-based dose-response analysis of liver transcriptional response to trichloroethylene in mouse. Mammalian Genome : Official Journal of the International Mammalian Genome Society. PMID 29353386 DOI: 10.1007/S00335-018-9734-Y |
0.397 |
|
| 2018 |
Chiu WA, Rusyn I. Advancing chemical risk assessment decision-making with population variability data: challenges and opportunities. Mammalian Genome : Official Journal of the International Mammalian Genome Society. PMID 29299621 DOI: 10.1007/S00335-017-9731-6 |
0.338 |
|
| 2018 |
Seniutkin O, Furuya S, Luo YS, Cichocki JA, Fukushima H, Kato Y, Sugimoto H, Matsumoto T, Uehara T, Rusyn I. Effects of pirfenidone in acute and sub-chronic liver fibrosis, and an initiation-promotion cancer model in the mouse. Toxicology and Applied Pharmacology. 339: 1-9. PMID 29197520 DOI: 10.1016/J.Taap.2017.11.024 |
0.366 |
|
| 2018 |
Luo YS, Furuya S, Chiu W, Rusyn I. Characterization of inter-tissue and inter-strain variability of TCE glutathione conjugation metabolites DCVG, DCVC, and NAcDCVC in the mouse. Journal of Toxicology and Environmental Health. Part A. 81: 37-52. PMID 29190187 DOI: 10.1080/15287394.2017.1408512 |
0.325 |
|
| 2018 |
Furuya S, Cichocki J, Kono H, Bataller R, Rusyn I. Comprehensive analysis of alcohol treatment in mouse model of acute-on-chronic liver injury Journal of Hepatology. 68: S610. DOI: 10.1016/S0168-8278(18)31474-0 |
0.313 |
|
| 2017 |
Lewis L, Crawford GE, Furey TS, Rusyn I. Genetic and epigenetic determinants of inter-individual variability in responses to toxicants. Current Opinion in Toxicology. 6: 50-59. PMID 29276797 DOI: 10.1016/J.Cotox.2017.08.006 |
0.324 |
|
| 2017 |
House JS, Grimm FA, Jima DD, Zhou YH, Rusyn I, Wright FA. A Pipeline for High-Throughput Concentration Response Modeling of Gene Expression for Toxicogenomics. Frontiers in Genetics. 8: 168. PMID 29163636 DOI: 10.3389/Fgene.2017.00168 |
0.331 |
|
| 2017 |
Pogribny IP, Dreval K, Kindrat I, Melnyk S, Jimenez L, de Conti A, Tryndyak V, Pogribna M, Ortega JF, James SJ, Rusyn I, Beland FA. Epigenetically mediated inhibition of S-adenosylhomocysteine hydrolase and the associated dysregulation of 1-carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 29127188 DOI: 10.1096/Fj.201700866R |
0.34 |
|
| 2017 |
Chappell GA, Israel JW, Simon JM, Pott S, Safi A, Eklund K, Sexton KG, Bodnar W, Lieb JD, Crawford GE, Rusyn I, Furey TS. Variation in DNA-Damage Responses to an Inhalational Carcinogen (1,3-Butadiene) in Relation to Strain-Specific Differences in Chromatin Accessibility and Gene Transcription Profiles in C57BL/6J and CAST/EiJ Mice. Environmental Health Perspectives. 125: 107006. PMID 29038090 DOI: 10.1289/Ehp1937 |
0.351 |
|
| 2017 |
Zhou YH, Cichocki JA, Soldatow VY, Scholl E, Gallins P, Jima D, Yoo HS, Chiu WA, Wright FA, Rusyn I. Comparative dose-response analysis of liver and kidney transcriptomic effects of trichloroethylene and tetrachloroethylene in B6C3F1 mouse. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 28973375 DOI: 10.1093/Toxsci/Kfx165 |
0.379 |
|
| 2017 |
Cichocki JA, Furuya S, Luo YS, Iwata Y, Konganti K, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I. Nonalcoholic Fatty Liver Disease Is a Susceptibility Factor for Perchloroethylene-Induced Liver Effects in Mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 159: 481. PMID 28962530 DOI: 10.1093/Toxsci/Kfx158 |
0.387 |
|
| 2017 |
Chiu WA, Guyton KZ, Martin MT, Reif DM, Rusyn I. Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups. Altex. PMID 28738424 DOI: 10.14573/Altex.1703231 |
0.513 |
|
| 2017 |
Luo YS, Cichocki JA, McDonald TJ, Rusyn I. Simultaneous detection of the tetrachloroethylene metabolites S-(1,2,2-trichlorovinyl) glutathione, S-(1,2,2-trichlorovinyl)-L-cysteine, and N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine in multiple mouse tissues via ultra-high performance liquid chromatography electrospray ionization tandem mass spectrometry. Journal of Toxicology and Environmental Health. Part A. 1-12. PMID 28696834 DOI: 10.1080/15287394.2017.1330585 |
0.308 |
|
| 2017 |
Venkatratnam A, Furuya S, Kosyk O, Gold A, Bodnar W, Konganti K, Threadgill DW, Gillespie KM, Aylor DL, Wright FA, Chiu WA, Rusyn I. Collaborative Cross mouse population enables refinements to characterization of the variability in toxicokinetics of trichloroethylene and provides genetic evidence for the role of PPAR pathway in its oxidative metabolism. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 28369613 DOI: 10.1093/Toxsci/Kfx065 |
0.336 |
|
| 2017 |
Dreval K, de Conti A, Furuya S, Beland FA, Rusyn I, Pogribny IP. miR-1247 blocks SOX9-mediated regeneration in alcohol- and fibrosis-associated acute kidney injury in mice. Toxicology. PMID 28285099 DOI: 10.1016/J.Tox.2017.03.004 |
0.323 |
|
| 2017 |
Sirenko O, Grimm FA, Ryan KR, Iwata Y, Chiu WA, Parham F, Wignall JA, Anson B, Cromwell EF, Behl M, Rusyn I, Tice RR. In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model. Toxicology and Applied Pharmacology. PMID 28259702 DOI: 10.1016/J.Taap.2017.02.020 |
0.35 |
|
| 2017 |
Cichocki JA, Furuya S, Konganti K, Luo YS, McDonald TJ, Iwata Y, Chiu WA, Threadgill DW, Pogribny IP, Rusyn I. Impact of nonalcoholic fatty liver disease on toxicokinetics of tetrachloroethylene. The Journal of Pharmacology and Experimental Therapeutics. PMID 28148637 DOI: 10.1124/Jpet.116.238790 |
0.39 |
|
| 2016 |
Grimm FA, Iwata Y, Sirenko O, Chappell GA, Wright FA, Reif DM, Braisted J, Gerhold DL, Yeakley JM, Shepard P, Seligmann B, Roy T, Boogaard PJ, Ketelslegers HB, Rohde AM, ... Rusyn I, et al. A chemical-biological similarity-based grouping of complex substances as a prototype approach for evaluating chemical alternatives. Green Chemistry : An International Journal and Green Chemistry Resource : Gc. 18: 4407-4419. PMID 28035192 DOI: 10.1039/C6Gc01147K |
0.327 |
|
| 2016 |
Furuya S, Chappell GA, Iwata Y, Uehara T, Kato Y, Kono H, Bataller R, Rusyn I. A mouse model of alcoholic liver fibrosis-associated acute kidney injury identifies key molecular pathways. Toxicology and Applied Pharmacology. PMID 27641628 DOI: 10.1016/J.Taap.2016.09.011 |
0.335 |
|
| 2016 |
Cichocki J, Guyton KZ, Guha N, Chiu WA, Rusyn I, Lash LH. Target Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data Gaps. The Journal of Pharmacology and Experimental Therapeutics. PMID 27511820 DOI: 10.1124/Jpet.116.232629 |
0.33 |
|
| 2016 |
Chappell G, Pogribny IP, Guyton KZ, Rusyn I. Epigenetic alterations induced by genotoxic occupational and environmental human chemical carcinogens: A systematic literature review. Mutation Research. Reviews in Mutation Research. 768: 27-45. PMID 27234561 DOI: 10.1016/J.Mrrev.2016.03.004 |
0.32 |
|
| 2016 |
Chappell G, Silva GO, Uehara T, Pogribny IP, Rusyn I. Characterization of copy number alterations in a mouse model of fibrosis-associated hepatocellular carcinoma reveals concordance with human disease. Cancer Medicine. PMID 26778414 DOI: 10.1002/Cam4.606 |
0.347 |
|
| 2015 |
Grimm FA, Iwata Y, Sirenko O, Bittner M, Rusyn I. High-Content Assay Multiplexing for Toxicity Screening in Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Hepatocytes. Assay and Drug Development Technologies. PMID 26539751 DOI: 10.1089/Adt.2015.659 |
0.338 |
|
| 2015 |
Low YS, Caster O, Bergvall T, Fourches D, Zang X, Norén GN, Rusyn I, Edwards R, Tropsha A. Cheminformatics-aided pharmacovigilance: application to Stevens-Johnson Syndrome. Journal of the American Medical Informatics Association : Jamia. PMID 26499102 DOI: 10.1093/Jamia/Ocv127 |
0.711 |
|
| 2015 |
Eduati F, Mangravite LM, Wang T, Tang H, Bare JC, Huang R, Norman T, Kellen M, Menden MP, Yang J, Zhan X, Zhong R, Xiao G, Xia M, Abdo N, ... ... Rusyn I, et al. Erratum: Prediction of human population responses to toxic compounds by a collaborative competition. Nature Biotechnology. 33: 1109. PMID 26448092 DOI: 10.1038/Nbt1015-1109A |
0.589 |
|
| 2015 |
Abdo N, Wetmore BA, Chappell GA, Shea D, Wright FA, Rusyn I. In vitro screening for population variability in toxicity of pesticide-containing mixtures. Environment International. 85: 147-55. PMID 26386728 DOI: 10.1016/J.Envint.2015.09.012 |
0.628 |
|
| 2015 |
Yoo HS, Cichocki JA, Kim S, Venkatratnam A, Iwata Y, Kosyk O, Bodnar W, Sweet S, Knap A, Wade T, Campbell J, Clewell HJ, Melnyk SB, Chiu WA, Rusyn I. The contribution of peroxisome proliferator-activated receptor alpha to the relationship between toxicokinetics and toxicodynamics of trichloroethylene. Toxicological Sciences : An Official Journal of the Society of Toxicology. PMID 26136231 DOI: 10.1093/Toxsci/Kfv134 |
0.676 |
|
| 2015 |
Marrone AK, Shpyleva S, Chappell G, Tryndyak V, Uehara T, Tsuchiya M, Beland FA, Rusyn I, Pogribny IP. Differentially expressed MicroRNAs provide mechanistic insight into fibrosis-associated liver carcinogenesis in mice. Molecular Carcinogenesis. PMID 25865624 DOI: 10.1002/Mc.22323 |
0.323 |
|
| 2015 |
Abdo N, Xia M, Brown CC, Kosyk O, Huang R, Sakamuru S, Zhou YH, Jack JR, Gallins P, Xia K, Li Y, Chiu WA, Motsinger-Reif AA, Austin CP, Tice RR, ... Rusyn I, et al. Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study. Environmental Health Perspectives. 123: 458-66. PMID 25622337 DOI: 10.1289/Ehp.1408775 |
0.625 |
|
| 2015 |
Yoo HS, Bradford BU, Kosyk O, Uehara T, Shymonyak S, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects. Journal of Toxicology and Environmental Health. Part A. 78: 32-49. PMID 25424545 DOI: 10.1080/15287394.2015.958418 |
0.614 |
|
| 2015 |
Yoo HS, Bradford BU, Kosyk O, Shymonyak S, Uehara T, Collins LB, Bodnar WM, Ball LM, Gold A, Rusyn I. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects. Journal of Toxicology and Environmental Health. Part A. 78: 15-31. PMID 25424544 DOI: 10.1080/15287394.2015.958417 |
0.68 |
|
| 2015 |
Guyton KZ, Loomis D, Grosse Y, El Ghissassi F, Benbrahim-Tallaa L, Guha N, Scoccianti C, Mattock H, Straif K, Blair A, Fritschi L, McLaughlin J, Sergi CM, Calaf GM, Le Curieux F, ... ... Rusyn I, et al. Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate The Lancet Oncology. 16: 490-491. DOI: 10.1016/S1470-2045(15)70134-8 |
0.466 |
|
| 2014 |
Lash LH, Chiu WA, Guyton KZ, Rusyn I. Trichloroethylene biotransformation and its role in mutagenicity, carcinogenicity and target organ toxicity. Mutation Research. Reviews in Mutation Research. 762: 22-36. PMID 25484616 DOI: 10.1016/J.Mrrev.2014.04.003 |
0.321 |
|
| 2014 |
Chappell G, Kobets T, O'Brien B, Tretyakova N, Sangaraju D, Kosyk O, Sexton KG, Bodnar W, Pogribny IP, Rusyn I. Epigenetic events determine tissue-specific toxicity of inhalational exposure to the genotoxic chemical 1,3-butadiene in male C57BL/6J mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 142: 375-84. PMID 25237060 DOI: 10.1093/Toxsci/Kfu191 |
0.357 |
|
| 2014 |
Uehara T, Pogribny IP, Rusyn I. The DEN and CCl4 -Induced Mouse Model of Fibrosis and Inflammation-Associated Hepatocellular Carcinoma. Current Protocols in Pharmacology / Editorial Board, S.J. Enna (Editor-in-Chief) ... [Et Al.]. 66: 14.30.1-14.30.10. PMID 25181010 DOI: 10.1002/0471141755.Ph1430S66 |
0.318 |
|
| 2014 |
Low YS, Sedykh AY, Rusyn I, Tropsha A. Integrative approaches for predicting in vivo effects of chemicals from their structural descriptors and the results of short-term biological assays. Current Topics in Medicinal Chemistry. 14: 1356-64. PMID 24805064 DOI: 10.2174/1568026614666140506121116 |
0.725 |
|
| 2014 |
Chiu WA, Campbell JL, Clewell HJ, Zhou YH, Wright FA, Guyton KZ, Rusyn I. Physiologically based pharmacokinetic (PBPK) modeling of interstrain variability in trichloroethylene metabolism in the mouse. Environmental Health Perspectives. 122: 456-63. PMID 24518055 DOI: 10.1289/Ehp.1307623 |
0.316 |
|
| 2014 |
Chappell G, Kutanzi K, Uehara T, Tryndyak V, Hong HH, Hoenerhoff M, Beland FA, Rusyn I, Pogribny IP. Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice. International Journal of Cancer. Journal International Du Cancer. 134: 2778-88. PMID 24242335 DOI: 10.1002/Ijc.28610 |
0.37 |
|
| 2014 |
Sirenko O, Hesley J, Rusyn I, Cromwell EF. High-content assays for hepatotoxicity using induced pluripotent stem cell-derived cells. Assay and Drug Development Technologies. 12: 43-54. PMID 24229356 DOI: 10.1089/Adt.2013.520 |
0.332 |
|
| 2014 |
Rusyn I, Chiu WA, Lash LH, Kromhout H, Hansen J, Guyton KZ. Trichloroethylene: Mechanistic, epidemiologic and other supporting evidence of carcinogenic hazard. Pharmacology & Therapeutics. 141: 55-68. PMID 23973663 DOI: 10.1016/J.Pharmthera.2013.08.004 |
0.322 |
|
| 2014 |
Marrone AK, Tryndyak V, Chappell G, Beland FA, Rusyn I, Pogribny IP. Abstract 5227: The microRNA profile is altered in fibrosis-associated hepatocarcinogenesis in mice Cancer Research. 74: 5227-5227. DOI: 10.1158/1538-7445.Am2014-5227 |
0.332 |
|
| 2014 |
Odena G, Morales-Ibanez O, Affo S, Furuya S, Rusyn I, Altamirano J, Sancho-Bru P, Arroyo V, Gines P, Caballeria J, Bataller R. P344 TRANSLATIONAL STUDY IDENTIFIES NEUTROPHIL GELATINASE-ASSOCIATED LIPOCALIN (NGAL) AS A POTENTIAL MEDIATOR OF LIVER INJURY AND FIBROGENESIS IN ALCOHOLIC HEPATITIS Journal of Hepatology. 60: S181-S182. DOI: 10.1016/S0168-8278(14)60506-7 |
0.347 |
|
| 2013 |
Sirenko O, Cromwell EF, Crittenden C, Wignall JA, Wright FA, Rusyn I. Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity. Toxicology and Applied Pharmacology. 273: 500-7. PMID 24095675 DOI: 10.1016/J.Taap.2013.09.017 |
0.312 |
|
| 2013 |
Low Y, Sedykh A, Fourches D, Golbraikh A, Whelan M, Rusyn I, Tropsha A. Integrative chemical-biological read-across approach for chemical hazard classification. Chemical Research in Toxicology. 26: 1199-208. PMID 23848138 DOI: 10.1021/Tx400110F |
0.725 |
|
| 2013 |
Soldatow VY, Lecluyse EL, Griffith LG, Rusyn I. In vitro models for liver toxicity testing. Toxicology Research. 2: 23-39. PMID 23495363 DOI: 10.1039/C2Tx20051A |
0.377 |
|
| 2013 |
Pogribny IP, Kutanzi K, Melnyk S, de Conti A, Tryndyak V, Montgomery B, Pogribna M, Muskhelishvili L, Latendresse JR, James SJ, Beland FA, Rusyn I. Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 2233-43. PMID 23439872 DOI: 10.1096/Fj.12-227116 |
0.338 |
|
| 2013 |
Uehara T, Ainslie GR, Kutanzi K, Pogribny IP, Muskhelishvili L, Izawa T, Yamate J, Kosyk O, Shymonyak S, Bradford BU, Boorman GA, Bataller R, Rusyn I. Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis. Toxicological Sciences : An Official Journal of the Society of Toxicology. 132: 53-63. PMID 23288052 DOI: 10.1093/Toxsci/Kfs342 |
0.377 |
|
| 2013 |
Uehara T, Kosyk O, Jeannot E, Bradford BU, Tech K, Macdonald JM, Boorman GA, Chatterjee S, Mason RP, Melnyk SB, Tryndyak VP, Pogribny IP, Rusyn I. Acetaminophen-induced acute liver injury in HCV transgenic mice. Toxicology and Applied Pharmacology. 266: 224-32. PMID 23200774 DOI: 10.1016/J.Taap.2012.11.019 |
0.336 |
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| 2013 |
Pogribny IP, Rusyn I. Environmental toxicants, epigenetics, and cancer. Advances in Experimental Medicine and Biology. 754: 215-32. PMID 22956504 DOI: 10.1007/978-1-4419-9967-2_11 |
0.308 |
|
| 2012 |
Tryndyak V, de Conti A, Kobets T, Kutanzi K, Koturbash I, Han T, Fuscoe JC, Latendresse JR, Melnyk S, Shymonyak S, Collins L, Ross SA, Rusyn I, Beland FA, Pogribny IP. Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 4592-602. PMID 22872676 DOI: 10.1096/Fj.12-209569 |
0.399 |
|
| 2012 |
Tryndyak VP, Latendresse JR, Montgomery B, Ross SA, Beland FA, Rusyn I, Pogribny IP. Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet. Toxicology and Applied Pharmacology. 262: 52-9. PMID 22561871 DOI: 10.1016/J.Taap.2012.04.018 |
0.319 |
|
| 2012 |
Rusyn I, Sedykh A, Low Y, Guyton KZ, Tropsha A. Predictive modeling of chemical hazard by integrating numerical descriptors of chemical structures and short-term toxicity assay data. Toxicological Sciences : An Official Journal of the Society of Toxicology. 127: 1-9. PMID 22387746 DOI: 10.1093/Toxsci/Kfs095 |
0.729 |
|
| 2012 |
Tsuchiya M, Ji C, Kosyk O, Shymonyak S, Melnyk S, Kono H, Tryndyak V, Muskhelishvili L, Pogribny IP, Kaplowitz N, Rusyn I. Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice. Hepatology (Baltimore, Md.). 56: 130-9. PMID 22307928 DOI: 10.1002/Hep.25641 |
0.357 |
|
| 2012 |
Lock EF, Abdo N, Huang R, Xia M, Kosyk O, O'Shea SH, Zhou YH, Sedykh A, Tropsha A, Austin CP, Tice RR, Wright FA, Rusyn I. Quantitative high-throughput screening for chemical toxicity in a population-based in vitro model. Toxicological Sciences : An Official Journal of the Society of Toxicology. 126: 578-88. PMID 22268004 DOI: 10.1093/Toxsci/Kfs023 |
0.644 |
|
| 2012 |
Rusyn I, Corton JC. Mechanistic considerations for human relevance of cancer hazard of di(2-ethylhexyl) phthalate. Mutation Research. 750: 141-58. PMID 22198209 DOI: 10.1016/J.Mrrev.2011.12.004 |
0.394 |
|
| 2011 |
Low Y, Uehara T, Minowa Y, Yamada H, Ohno Y, Urushidani T, Sedykh A, Muratov E, Kuz'min V, Fourches D, Zhu H, Rusyn I, Tropsha A. Predicting drug-induced hepatotoxicity using QSAR and toxicogenomics approaches. Chemical Research in Toxicology. 24: 1251-62. PMID 21699217 DOI: 10.1021/Tx200148A |
0.744 |
|
| 2011 |
Gatti DM, Lu L, Williams RW, Sun W, Wright FA, Threadgill DW, Rusyn I. MicroRNA expression in the livers of inbred mice. Mutation Research. 714: 126-33. PMID 21616085 DOI: 10.1016/J.Mrfmmm.2011.05.007 |
0.633 |
|
| 2011 |
Koturbash I, Scherhag A, Sorrentino J, Sexton K, Bodnar W, Swenberg JA, Beland FA, Pardo-Manuel Devillena F, Rusyn I, Pogribny IP. Epigenetic mechanisms of mouse interstrain variability in genotoxicity of the environmental toxicant 1,3-butadiene. Toxicological Sciences : An Official Journal of the Society of Toxicology. 122: 448-56. PMID 21602187 DOI: 10.1093/Toxsci/Kfr133 |
0.352 |
|
| 2011 |
Jeannot E, Pogribny IP, Beland FA, Rusyn I. Chronic administration of ethanol leads to an increased incidence of hepatocellular adenoma by promoting H-ras-mutated cells. Cancer Letters. 301: 161-7. PMID 21168264 DOI: 10.1016/J.Canlet.2010.11.010 |
0.305 |
|
| 2011 |
Koturbash I, Scherhag A, Sorrentino J, Sexton K, Bodnar W, Tryndyak V, Latendresse JR, Swenberg JA, Beland FA, Pogribny IP, Rusyn I. Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-butadiene. Environmental Health Perspectives. 119: 635-40. PMID 21147608 DOI: 10.1289/Ehp.1002910 |
0.368 |
|
| 2011 |
Bradford BU, Lock EF, Kosyk O, Kim S, Uehara T, Harbourt D, DeSimone M, Threadgill DW, Tryndyak V, Pogribny IP, Bleyle L, Koop DR, Rusyn I. Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice. Toxicological Sciences : An Official Journal of the Society of Toxicology. 120: 206-17. PMID 21135412 DOI: 10.1093/Toxsci/Kfq362 |
0.416 |
|
| 2011 |
Sedykh A, Zhu H, Tang H, Zhang L, Richard A, Rusyn I, Tropsha A. Use of in vitro HTS-derived concentration-response data as biological descriptors improves the accuracy of QSAR models of in vivo toxicity. Environmental Health Perspectives. 119: 364-70. PMID 20980217 DOI: 10.1289/Ehp.1002476 |
0.346 |
|
| 2011 |
O'Shea SH, Schwarz J, Kosyk O, Ross PK, Ha MJ, Wright FA, Rusyn I. In vitro screening for population variability in chemical toxicity. Toxicological Sciences : An Official Journal of the Society of Toxicology. 119: 398-407. PMID 20952501 DOI: 10.1093/Toxsci/Kfq322 |
0.349 |
|
| 2010 |
Gatti DM, Barry WT, Nobel AB, Rusyn I, Wright FA. Heading down the wrong pathway: on the influence of correlation within gene sets. Bmc Genomics. 11: 574. PMID 20955544 DOI: 10.1186/1471-2164-11-574 |
0.62 |
|
| 2010 |
Rusyn I, Gatti DM, Wiltshire T, Wilshire T, Kleeberger SR, Threadgill DW. Toxicogenetics: population-based testing of drug and chemical safety in mouse models. Pharmacogenomics. 11: 1127-36. PMID 20704464 DOI: 10.2217/Pgs.10.100 |
0.647 |
|
| 2010 |
Gatti DM, Zhao N, Chesler EJ, Bradford BU, Shabalin AA, Yordanova R, Lu L, Rusyn I. Sex-specific gene expression in the BXD mouse liver. Physiological Genomics. 42: 456-68. PMID 20551147 DOI: 10.1152/Physiolgenomics.00110.2009 |
0.664 |
|
| 2010 |
Tsuchiya M, Parker JS, Kono H, Matsuda M, Fujii H, Rusyn I. Gene expression in nontumoral liver tissue and recurrence-free survival in hepatitis C virus-positive hepatocellular carcinoma. Molecular Cancer. 9: 74. PMID 20380719 DOI: 10.1186/1476-4598-9-74 |
0.306 |
|
| 2010 |
Rodgers AD, Zhu H, Fourches D, Rusyn I, Tropsha A. Modeling liver-related adverse effects of drugs using knearest neighbor quantitative structure-activity relationship method. Chemical Research in Toxicology. 23: 724-32. PMID 20192250 DOI: 10.1021/Tx900451R |
0.352 |
|
| 2010 |
Powell CL, Bradford BU, Craig CP, Tsuchiya M, Uehara T, O'Connell TM, Pogribny IP, Melnyk S, Koop DR, Bleyle L, Threadgill DW, Rusyn I. Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors. Toxicological Sciences : An Official Journal of the Society of Toxicology. 115: 131-9. PMID 20118189 DOI: 10.1093/Toxsci/Kfq031 |
0.568 |
|
| 2010 |
Rusyn I, Gatti DM, Wiltshire T, Kleeberger SR, Threadgill DW. Erratum: Toxicogenetics: Population-based testing of drug and chemical safety in mouse models (Pharmacogenomics (2010) 11:8 (1127-1136)) Pharmacogenomics. 11. DOI: 10.2217/Pgs.10.148 |
0.618 |
|
| 2009 |
Zhu H, Ye L, Richard A, Golbraikh A, Wright FA, Rusyn I, Tropsha A. A novel two-step hierarchical quantitative structure-activity relationship modeling work flow for predicting acute toxicity of chemicals in rodents. Environmental Health Perspectives. 117: 1257-64. PMID 19672406 DOI: 10.1289/Ehp.0800471 |
0.33 |
|
| 2009 |
Gatti DM, Harrill AH, Wright FA, Threadgill DW, Rusyn I. Replication and narrowing of gene expression quantitative trait loci using inbred mice. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 20: 437-46. PMID 19609828 DOI: 10.1007/S00335-009-9199-0 |
0.642 |
|
| 2009 |
Pogribny IP, Tryndyak VP, Bagnyukova TV, Melnyk S, Montgomery B, Ross SA, Latendresse JR, Rusyn I, Beland FA. Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet. Journal of Hepatology. 51: 176-86. PMID 19450891 DOI: 10.1016/J.Jhep.2009.03.021 |
0.319 |
|
| 2009 |
Harrill AH, Ross PK, Gatti DM, Threadgill DW, Rusyn I. Population-based discovery of toxicogenomics biomarkers for hepatotoxicity using a laboratory strain diversity panel. Toxicological Sciences : An Official Journal of the Society of Toxicology. 110: 235-43. PMID 19420014 DOI: 10.1093/Toxsci/Kfp096 |
0.674 |
|
| 2009 |
Harrill AH, Watkins PB, Su S, Ross PK, Harbourt DE, Stylianou IM, Boorman GA, Russo MW, Sackler RS, Harris SC, Smith PC, Tennant R, Bogue M, Paigen K, Harris C, ... ... Rusyn I, et al. Mouse population-guided resequencing reveals that variants in CD44 contribute to acetaminophen-induced liver injury in humans. Genome Research. 19: 1507-15. PMID 19416960 DOI: 10.1101/Gr.090241.108 |
0.372 |
|
| 2009 |
Kim S, Kim D, Pollack GM, Collins LB, Rusyn I. Pharmacokinetic analysis of trichloroethylene metabolism in male B6C3F1 mice: Formation and disposition of trichloroacetic acid, dichloroacetic acid, S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine. Toxicology and Applied Pharmacology. 238: 90-9. PMID 19409406 DOI: 10.1016/J.Taap.2009.04.019 |
0.321 |
|
| 2009 |
Ross PK, Woods CG, Bradford BU, Kosyk O, Gatti DM, Cunningham ML, Rusyn I. Time-course comparison of xenobiotic activators of CAR and PPARalpha in mouse liver. Toxicology and Applied Pharmacology. 235: 199-207. PMID 19136022 DOI: 10.1016/J.Taap.2008.12.011 |
0.752 |
|
| 2009 |
Gatti DM, Sypa M, Rusyn I, Wright FA, Barry WT. SAFEGUI: resampling-based tests of categorical significance in gene expression data made easy. Bioinformatics (Oxford, England). 25: 541-2. PMID 19098030 DOI: 10.1093/Bioinformatics/Btn655 |
0.63 |
|
| 2009 |
Gatti DM, Shabalin AA, Lam TC, Wright FA, Rusyn I, Nobel AB. FastMap: fast eQTL mapping in homozygous populations. Bioinformatics (Oxford, England). 25: 482-9. PMID 19091771 DOI: 10.1093/Bioinformatics/Btn648 |
0.613 |
|
| 2008 |
Harrill AH, Rusyn I. Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity. Expert Opinion On Drug Metabolism & Toxicology. 4: 1379-89. PMID 18950280 DOI: 10.1517/17425255.4.11.1379 |
0.328 |
|
| 2008 |
Tsuchiya M, Kono H, Matsuda M, Fujii H, Rusyn I. Protective effect of Juzen-taiho-to on hepatocarcinogenesis is mediated through the inhibition of Kupffer cell-induced oxidative stress. International Journal of Cancer. Journal International Du Cancer. 123: 2503-11. PMID 18785209 DOI: 10.1002/Ijc.23828 |
0.346 |
|
| 2008 |
Bradford BU, O'Connell TM, Han J, Kosyk O, Shymonyak S, Ross PK, Winnike J, Kono H, Rusyn I. Metabolomic profiling of a modified alcohol liquid diet model for liver injury in the mouse uncovers new markers of disease. Toxicology and Applied Pharmacology. 232: 236-43. PMID 18674555 DOI: 10.1016/J.Taap.2008.06.022 |
0.343 |
|
| 2008 |
Pogribny IP, Tryndyak VP, Boureiko A, Melnyk S, Bagnyukova TV, Montgomery B, Rusyn I. Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver. Mutation Research. 644: 17-23. PMID 18639561 DOI: 10.1016/J.Mrfmmm.2008.06.009 |
0.318 |
|
| 2008 |
Zhu H, Rusyn I, Richard A, Tropsha A. Use of cell viability assay data improves the prediction accuracy of conventional quantitative structure-activity relationship models of animal carcinogenicity. Environmental Health Perspectives. 116: 506-13. PMID 18414635 DOI: 10.1289/Ehp.10573 |
0.315 |
|
| 2007 |
Woods CG, Kosyk O, Bradford BU, Ross PK, Burns AM, Cunningham ML, Qu P, Ibrahim JG, Rusyn I. Time course investigation of PPARalpha- and Kupffer cell-dependent effects of WY-14,643 in mouse liver using microarray gene expression. Toxicology and Applied Pharmacology. 225: 267-77. PMID 17950772 DOI: 10.1016/J.Taap.2007.08.028 |
0.626 |
|
| 2007 |
Pogribny IP, Tryndyak VP, Woods CG, Witt SE, Rusyn I. Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor alpha. Mutation Research. 625: 62-71. PMID 17586532 DOI: 10.1016/J.Mrfmmm.2007.05.004 |
0.605 |
|
| 2007 |
Beyer RP, Fry RC, Lasarev MR, McConnachie LA, Meira LB, Palmer VS, Powell CL, Ross PK, Bammler TK, Bradford BU, Cranson AB, Cunningham ML, Fannin RD, Higgins GM, Hurban P, ... ... Rusyn I, et al. Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses. Toxicological Sciences : An Official Journal of the Society of Toxicology. 99: 326-37. PMID 17562736 DOI: 10.1093/Toxsci/Kfm150 |
0.724 |
|
| 2007 |
Woods CG, Heuvel JP, Rusyn I. Genomic profiling in nuclear receptor-mediated toxicity. Toxicologic Pathology. 35: 474-94. PMID 17562482 DOI: 10.1080/01926230701311351 |
0.58 |
|
| 2007 |
Peffer RC, Moggs JG, Pastoor T, Currie RA, Wright J, Milburn G, Waechter F, Rusyn I. Mouse liver effects of cyproconazole, a triazole fungicide: role of the constitutive androstane receptor. Toxicological Sciences : An Official Journal of the Society of Toxicology. 99: 315-25. PMID 17557908 DOI: 10.1093/Toxsci/Kfm154 |
0.384 |
|
| 2007 |
Gatti D, Maki A, Chesler EJ, Kirova R, Kosyk O, Lu L, Manly KF, Williams RW, Perkins A, Langston MA, Threadgill DW, Rusyn I. Genome-level analysis of genetic regulation of liver gene expression networks. Hepatology (Baltimore, Md.). 46: 548-57. PMID 17542012 DOI: 10.1002/Hep.21682 |
0.676 |
|
| 2007 |
Woods CG, Burns AM, Bradford BU, Ross PK, Kosyk O, Swenberg JA, Cunningham ML, Rusyn I. WY-14,643 induced cell proliferation and oxidative stress in mouse liver are independent of NADPH oxidase. Toxicological Sciences : An Official Journal of the Society of Toxicology. 98: 366-74. PMID 17483499 DOI: 10.1093/Toxsci/Kfm104 |
0.621 |
|
| 2007 |
Hammond LE, Albright CD, He L, Rusyn I, Watkins SM, Doughman SD, Lemasters JJ, Coleman RA. Increased oxidative stress is associated with balanced increases in hepatocyte apoptosis and proliferation in glycerol-3-phosphate acyltransferase-1 deficient mice. Experimental and Molecular Pathology. 82: 210-9. PMID 17258706 DOI: 10.1016/J.Yexmp.2006.12.004 |
0.347 |
|
| 2007 |
Woods CG, Burns AM, Maki A, Bradford BU, Cunningham ML, Connor HD, Kadiiska MB, Mason RP, Peters JM, Rusyn I. Sustained formation of alpha-(4-pyridyl-1-oxide)-N-tert-butylnitrone radical adducts in mouse liver by peroxisome proliferators is dependent upon peroxisome proliferator-activated receptor-alpha, but not NADPH oxidase. Free Radical Biology & Medicine. 42: 335-42. PMID 17210446 DOI: 10.1016/J.Freeradbiomed.2006.10.053 |
0.609 |
|
| 2007 |
Maki A, Kono H, Gupta M, Asakawa M, Suzuki T, Matsuda M, Fujii H, Rusyn I. Predictive power of biomarkers of oxidative stress and inflammation in patients with hepatitis C virus-associated hepatocellular carcinoma. Annals of Surgical Oncology. 14: 1182-90. PMID 17195915 DOI: 10.1245/S10434-006-9049-1 |
0.3 |
|
| 2007 |
Pogribny IP, Tryndyak VP, Muskhelishvili L, Rusyn I, Ross SA. Methyl deficiency, alterations in global histone modifications, and carcinogenesis. The Journal of Nutrition. 137: 216S-222S. PMID 17182829 DOI: 10.1093/Jn/137.1.216S |
0.312 |
|
| 2007 |
Roberts RA, Ganey PE, Ju C, Kamendulis LM, Rusyn I, Klaunig JE. Role of the Kupffer cell in mediating hepatic toxicity and carcinogenesis. Toxicological Sciences : An Official Journal of the Society of Toxicology. 96: 2-15. PMID 17122412 DOI: 10.1093/Toxsci/Kfl173 |
0.376 |
|
| 2006 |
Rusyn I, Peters JM, Cunningham ML. Modes of action and species-specific effects of di-(2-ethylhexyl)phthalate in the liver. Critical Reviews in Toxicology. 36: 459-79. PMID 16954067 DOI: 10.1080/10408440600779065 |
0.435 |
|
| 2006 |
Kono H, Woods CG, Maki A, Connor HD, Mason RP, Rusyn I, Fujii H. Electron spin resonance and spin trapping technique provide direct evidence that edaravone prevents acute ischemia-reperfusion injury of the liver by limiting free radical-mediated tissue damage. Free Radical Research. 40: 579-88. PMID 16753835 DOI: 10.1080/10715760600606374 |
0.57 |
|
| 2006 |
Powell CL, Kosyk O, Ross PK, Schoonhoven R, Boysen G, Swenberg JA, Heinloth AN, Boorman GA, Cunningham ML, Paules RS, Rusyn I. Phenotypic anchoring of acetaminophen-induced oxidative stress with gene expression profiles in rat liver. Toxicological Sciences : An Official Journal of the Society of Toxicology. 93: 213-22. PMID 16751229 DOI: 10.1093/Toxsci/Kfl030 |
0.642 |
|
| 2005 |
Powell CL, Kosyk O, Bradford BU, Parker JS, Lobenhofer EK, Denda A, Uematsu F, Nakae D, Rusyn I. Temporal correlation of pathology and DNA damage with gene expression in a choline-deficient model of rat liver injury. Hepatology (Baltimore, Md.). 42: 1137-47. PMID 16250055 DOI: 10.1002/Hep.20910 |
0.641 |
|
| 2005 |
Powell CL, Swenberg JA, Rusyn I. Expression of base excision DNA repair genes as a biomarker of oxidative DNA damage. Cancer Letters. 229: 1-11. PMID 16157213 DOI: 10.1016/J.Canlet.2004.12.002 |
0.584 |
|
| 2005 |
Uematsu F, Takahashi M, Yoshida M, Igarashi M, Watanabe N, Suzuki N, Abe M, Rusyn I, Floyd RA, Nakae D. Distinct patterns of gene expression in hepatocellular carcinomas and adjacent non-cancerous, cirrhotic liver tissues in rats fed a choline-deficient, L-amino acid-defined diet. Cancer Science. 96: 414-24. PMID 16053513 DOI: 10.1111/J.1349-7006.2005.00069.X |
0.325 |
|
| 2005 |
Rusyn I, Asakura S, Li Y, Kosyk O, Koc H, Nakamura J, Upton PB, Swenberg JA. Effects of ethylene oxide and ethylene inhalation on DNA adducts, apurinic/apyrimidinic sites and expression of base excision DNA repair genes in rat brain, spleen, and liver. Dna Repair. 4: 1099-110. PMID 16051529 DOI: 10.1016/J.Dnarep.2005.05.009 |
0.342 |
|
| 2005 |
Bradford BU, Rusyn I. Swift increase in alcohol metabolism (SIAM): understanding the phenomenon of hypermetabolism in liver. Alcohol (Fayetteville, N.Y.). 35: 13-7. PMID 15922133 DOI: 10.1016/J.Alcohol.2004.12.001 |
0.325 |
|
| 2005 |
Bradford BU, Kono H, Isayama F, Kosyk O, Wheeler MD, Akiyama TE, Bleye L, Krausz KW, Gonzalez FJ, Koop DR, Rusyn I. Cytochrome P450 CYP2E1, but not nicotinamide adenine dinucleotide phosphate oxidase, is required for ethanol-induced oxidative DNA damage in rodent liver. Hepatology (Baltimore, Md.). 41: 336-44. PMID 15660387 DOI: 10.1002/Hep.20532 |
0.348 |
|
| 2005 |
Hays T, Rusyn I, Burns AM, Kennett MJ, Ward JM, Gonzalez FJ, Peters JM. Role of peroxisome proliferator-activated receptor-alpha (PPARalpha) in bezafibrate-induced hepatocarcinogenesis and cholestasis. Carcinogenesis. 26: 219-27. PMID 15447978 DOI: 10.1093/Carcin/Bgh285 |
0.362 |
|
| 2004 |
Rusyn I, Asakura S, Pachkowski B, Bradford BU, Denissenko MF, Peters JM, Holland SM, Reddy JK, Cunningham ML, Swenberg JA. Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferators. Cancer Research. 64: 1050-7. PMID 14871837 DOI: 10.1158/0008-5472.Can-03-3027 |
0.338 |
|
| 2003 |
Wheeler MD, Smutney OM, Check JF, Rusyn I, Schulte-Hermann R, Thurman RG. Impaired Ras membrane association and activation in PPARalpha knockout mice after partial hepatectomy. American Journal of Physiology. Gastrointestinal and Liver Physiology. 284: G302-12. PMID 12388208 DOI: 10.1152/Ajpgi.00175.2002 |
0.437 |
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| 2003 |
RUSYN I, KONO H, KOSYK O, BRADFORD B. 522 Cytochrome P450 2E1, but not NADPH oxidase is required for ethanol-induced DNA damage and upregulation of DNA repair genes in mouse liver Hepatology. 38: 410-410. DOI: 10.1016/S0270-9139(03)80564-5 |
0.31 |
|
| 2002 |
Yin M, Zhong Z, Connor HD, Bunzendahl H, Finn WF, Rusyn I, Li X, Raleigh JA, Mason RP, Thurman RG. Protective effect of glycine on renal injury induced by ischemia-reperfusion in vivo. American Journal of Physiology. Renal Physiology. 282: F417-23. PMID 11832421 DOI: 10.1152/Ajprenal.00011.2001 |
0.664 |
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| 2001 |
Xu S, Zhu BT, Turan V, Rusyn I, Thurman R, Peters JM, Gonzalez FJ, Conney AH. PPARα-Dependent Induction of Liver Microsomal Esterification of Estradiol and Testosterone by a Prototypical Peroxisome Proliferator. Endocrinology. 142: 3554-3557. PMID 28201440 DOI: 10.1210/endo.142.8.8330 |
0.472 |
|
| 2001 |
Yamashina S, Konno A, Wheeler MD, Rusyn I, Rusyn EV, Cox AD, Thurman RG. Endothelial cells contain a glycine-gated chloride channel Nutrition and Cancer. 40: 197-204. PMID 11962256 DOI: 10.1207/S15327914Nc402_17 |
0.471 |
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| 2001 |
Wheeler MD, Kono H, Yin M, Nakagami M, Uesugi T, Arteel GE, Gäbele E, Rusyn I, Yamashina S, Froh M, Adachi Y, Iimuro Y, Bradford BU, Smutney OM, Connor HD, et al. The role of Kupffer cell oxidant production in early ethanol-induced liver disease. Free Radical Biology & Medicine. 31: 1544-9. PMID 11744328 DOI: 10.1016/S0891-5849(01)00748-1 |
0.556 |
|
| 2001 |
Yin M, Gäbele E, Wheeler MD, Connor H, Bradford BU, Dikalova A, Rusyn I, Mason R, Thurman RG. Alcohol-induced free radicals in mice: Direct toxicants or signaling molecules? Hepatology. 34: 935-942. PMID 11679964 DOI: 10.1053/Jhep.2001.28888 |
0.518 |
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| 2001 |
Xu S, Zhu BT, Turan V, Rusyn I, Thurman R, Peters JM, Gonzalez FJ, Conney AH. PPARα-dependent induction of liver microsomal esterification of estradiol and testosterone by a prototypical peroxisome proliferator Endocrinology. 142: 3554-3557. PMID 11459802 DOI: 10.1210/Endo.142.8.8330 |
0.541 |
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| 2001 |
Kono H, Uesugi T, Froh M, Rusyn I, Bradford BU, Thurman RG. ICAM-1 is involved in the mechanism of alcohol-induced liver injury: studies with knockout mice. American Journal of Physiology. Gastrointestinal and Liver Physiology. 280: G1289-95. PMID 11352823 DOI: 10.1152/Ajpgi.2001.280.6.G1289 |
0.538 |
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| 2001 |
Kono H, Nakagami M, Rusyn I, Connor HD, Stefanovic B, Brenner DA, Mason RP, Arteel GE, Thurman RG. Development of an animal model of chronic alcohol-induced pancreatitis in the rat American Journal of Physiology - Gastrointestinal and Liver Physiology. 280. PMID 11352811 DOI: 10.1152/Ajpgi.2001.280.6.G1178 |
0.494 |
|
| 2001 |
Wheeler MD, Yamashina S, Froh M, Rusyn I, Thurman RG. Adenoviral gene delivery can inactivate Kupffer cells: role of oxidants in NF-kappaB activation and cytokine production. Journal of Leukocyte Biology. 69: 622-30. PMID 11310849 |
0.471 |
|
| 2001 |
Kono H, Rusyn I, Uesugi T, Yamashina S, Connor HD, Dikalova A, Mason RP, Thurman RG. Diphenyleneiodonium sulfate, an NADPH oxidase inhibitor, prevents early alcohol-induced liver injury in the rat American Journal of Physiology - Gastrointestinal and Liver Physiology. 280. PMID 11292610 DOI: 10.1152/Ajpgi.2001.280.5.G1005 |
0.544 |
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| 2001 |
Wheeler MD, Kono H, Yin M, Rusyn I, Froh M, Connor HD, Mason RP, Samulski RJ, Thurman RG. Delivery of the Cu/Zn-superoxide dismutase gene with adenovirus reduces early alcohol-induced liver injury in rats. Gastroenterology. 120: 1241-50. PMID 11266387 DOI: 10.1053/Gast.2001.23253 |
0.519 |
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| 2001 |
Rusyn I, Kadiiska MB, Dikalova A, Kono H, Yin M, Tsuchiya K, Mason RP, Peters JM, Gonzalez FJ, Segal BH, Holland SM, Thurman RG. Phthalates rapidly increase production of reactive oxygen species in vivo: role of Kupffer cells. Molecular Pharmacology. 59: 744-50. PMID 11259618 DOI: 10.1124/Mol.59.4.744 |
0.524 |
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| 2001 |
Kono H, Arteel GE, Rusyn I, Sies H, Thurman RG. Ebselen prevents early alcohol-induced liver injury in rats. Free Radical Biology & Medicine. 30: 403-11. PMID 11182296 DOI: 10.1016/S0891-5849(00)00490-1 |
0.533 |
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| 2001 |
Wheeler MD, Yamashina S, Froh M, Rusyn I, Thurman RG. Adenoviral gene delivery can inactivate Kupffer cells: role of oxidants in NF-κB activation and cytokine production Journal of Leukocyte Biology. 69: 622-630. DOI: 10.1189/Jlb.69.4.622 |
0.532 |
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| 2000 |
Rusyn I, Rose ML, Bojes HK, Thurman RG. Novel role of oxidants in the molecular mechanism of action of peroxisome proliferators Antioxidants and Redox Signaling. 2: 607-621. PMID 11229371 DOI: 10.1089/15230860050192350 |
0.52 |
|
| 2000 |
Kono H, Bradford BU, Rusyn I, Fujii H, Matsumoto Y, Yin M, Thurman RG. Development of an intragastric enteral model in the mouse: Studies of alcohol-induced liver disease using knockout technology Journal of Hepato-Biliary-Pancreatic Surgery. 7: 395-400. PMID 11180860 DOI: 10.1007/S005340070034 |
0.546 |
|
| 2000 |
Rusyn I, Denissenko MF, Wong VA, Butterworth BE, Cunningham ML, Upton PB, Thurman RG, Swenberg JA. Expression of base excision repair enzymes in rat and mouse liver is induced by peroxisome proliferators and is dependent upon carcinogenic potency. Carcinogenesis. 21: 2141-5. PMID 11133801 DOI: 10.1093/Carcin/21.12.2141 |
0.504 |
|
| 2000 |
Yamashina S, Wheeler MD, Rusyn I, Ikejima K, Sato N, Thurman RG. Tolerance and sensitization to endotoxin in Kupffer cells caused by acute ethanol involve interleukin-1 receptor-associated kinase Biochemical and Biophysical Research Communications. 277: 686-690. PMID 11062014 DOI: 10.1006/Bbrc.2000.3738 |
0.416 |
|
| 2000 |
Wheeler MD, Kono H, Rusyn I, Arteel GE, McCarty D, Jude Samulski R, Thurman RG. Chronic ethanol increases adeno-associated viral transgene expression in rat liver via oxidant and NFκB-dependent mechanisms Hepatology. 32: 1050-1059. PMID 11050056 DOI: 10.1053/Jhep.2000.19339 |
0.533 |
|
| 2000 |
Kono H, Rusyn I, Yin M, Gäbele E, Yamashina S, Dikalova A, Kadiiska MB, Connor HD, Mason RP, Segal BH, Bradford BU, Holland SM, Thurman RG. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. The Journal of Clinical Investigation. 106: 867-72. PMID 11018074 DOI: 10.1172/Jci9020 |
0.497 |
|
| 2000 |
Rusyn I, Yamashina S, Segal BH, Schoonhoven R, Holland SM, Cattley RC, Swenberg JA, Thurman RG. Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators. Cancer Research. 60: 4798-803. PMID 10987289 |
0.491 |
|
| 2000 |
Kono H, Wheeler MD, Rusyn I, Lin M, Seabra V, Rivera CA, Bradford BU, Forman DT, Thurman RG. Gender differences in early alcohol-induced liver injury: Role of CD14, NF-κB, and TNF-α American Journal of Physiology - Gastrointestinal and Liver Physiology. 278. PMID 10762620 DOI: 10.1152/Ajpgi.2000.278.4.G652 |
0.52 |
|
| 2000 |
Yin M, Rusyn I, Schoonhoven R, Graves LM, Rusyn EV, Li X, Li F, Cox AD, Harding TW, Bunzendahl H, Swenberg JA, Thurman RG. Inhibition of chronic rejection of aortic allografts by dietary glycine. Transplantation. 69: 773-80. PMID 10755525 DOI: 10.1097/00007890-200003150-00017 |
0.679 |
|
| 2000 |
Peters JM, Rusyn I, Rose ML, Gonzalez FJ, Thurman RG. Peroxisome proliferator-activated receptor α is restricted to hepatic parenchymal cells, not Kupffer cells: Implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis Carcinogenesis. 21: 823-826. PMID 10753222 DOI: 10.1093/Carcin/21.4.823 |
0.479 |
|
| 2000 |
Kono H, Rusyn I, Bradford BU, Connor HD, Mason RP, Thurman RG. Allopurinol prevents early alcohol-induced liver injury in rats Journal of Pharmacology and Experimental Therapeutics. 293: 296-303. PMID 10734182 |
0.448 |
|
| 2000 |
Rose ML, Rusyn I, Bojes HK, Belyea J, Cattley RC, Thurman RG. Role of Kupffer cells and oxidants in signaling peroxisome proliferator-induced hepatocyte proliferation Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 448: 179-192. PMID 10725471 DOI: 10.1016/S0027-5107(99)00235-3 |
0.467 |
|
| 2000 |
Iimuro Y, Bradford BU, Yamashina S, Rusyn I, Nakagami M, Enomoto N, Kono H, Frey W, Forman D, Brenner D, Thurman RG. The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat Hepatology. 31: 391-398. PMID 10655262 DOI: 10.1002/Hep.510310219 |
0.512 |
|
| 1999 |
Wheeler MD, Ikejema K, Enomoto N, Stacklewitz RF, Seabra V, Zhong Z, Yin M, Schemmer P, Rose ML, Rusyn I, Bradford B, Thurman RG. Glycine: A new anti-inflammatory immunonutrient Cellular and Molecular Life Sciences. 56: 843-856. PMID 11212343 DOI: 10.1007/S000180050030 |
0.443 |
|
| 1999 |
Rusyn I, Bradham CA, Cohn L, Schoonhoven R, Swenberg JA, Brenner DA, Thurman RG. Corn oil rapidly activates nuclear factor-kappaB in hepatic Kupffer cells by oxidant-dependent mechanisms. Carcinogenesis. 20: 2095-100. PMID 10545411 DOI: 10.1093/Carcin/20.11.2095 |
0.503 |
|
| 1999 |
Arteel GE, Kadiiska MB, Rusyn I, Bradford BU, Mason RP, Raleigh JA, Thurman RG. Oxidative stress occurs in perfused rat liver at low oxygen tension by mechanisms involving peroxynitrite Molecular Pharmacology. 55: 708-715. PMID 10101029 |
0.45 |
|
| 1999 |
Rose ML, Rusyn I, Bojes HK, Germolec DR, Luster M, Thurman RG. Role of kupffer cells in peroxisome proliferator-induced hepatocyte proliferation Drug Metabolism Reviews. 31: 87-116. PMID 10065367 DOI: 10.1081/Dmr-100101909 |
0.496 |
|
| 1999 |
Stachlewitz RF, Seabra V, Bradford B, Bradham CA, Rusyn I, Germolec D, Thurman RG. Glycine and uridine prevent D-galactosamine hepatotoxicity in the rat: Role of Kupffer cells Hepatology. 29: 737-745. PMID 10051475 DOI: 10.1002/Hep.510290335 |
0.486 |
|
| 1999 |
Rusyn I, Kadiiska M, Dikalova A, Kono H, Mason R, Thurman R. Phthalates rapidly increase reactive oxygen species in vivo Free Radical Biology and Medicine. 27: S148. DOI: 10.1016/S0891-5849(99)90989-9 |
0.44 |
|
| 1998 |
Rusyn I, Tsukamoto H, Thurman RG. WY-14 643 rapidly activates nuclear factor κB in Kupffer cells before hepatocytes Carcinogenesis. 19: 1217-1222. PMID 9683180 DOI: 10.1093/Carcin/19.7.1217 |
0.518 |
|
| 1998 |
Rusyn I, Segal B, Holland S, Thurman R. NADPH oxidase is the source of oxidants for activation of NF-κB by the peroxisome proliferator WY-14,643 (WY) Free Radical Biology and Medicine. 25: S118. DOI: 10.1016/S0891-5849(98)90364-1 |
0.467 |
|
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