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Jayakrishnan Nandakumar, Ph.D. - Publications

Affiliations: 
2007 Weill Cornell Medical College, New York, NY, United States 
Area:
Biochemistry, Molecular Biology
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Manthei KA, Munson LM, Nandakumar J, Simmons LA. Structural and biochemical characterization of the mitomycin C repair exonuclease MrfB. Nucleic Acids Research. PMID 38661211 DOI: 10.1093/nar/gkae308  0.411
2024 Padmanaban S, Lambacher NJ, Tesmer VM, Zhang J, Shibuya H, Nandakumar J. telomere-binding proteins TEBP-1 and TEBP-2 adapt the Myb module to dimerize and bind telomeric DNA. Proceedings of the National Academy of Sciences of the United States of America. 121: e2316651121. PMID 38588418 DOI: 10.1073/pnas.2316651121  0.45
2024 Manthei KA, Munson LM, Nandakumar J, Simmons LA. Structural and biochemical characterization of the mitomycin C repair exonuclease MrfB. Biorxiv : the Preprint Server For Biology. PMID 38405983 DOI: 10.1101/2024.02.15.580553  0.41
2023 Tesmer VM, Brenner KA, Nandakumar J. Human POT1 protects the telomeric ds-ss DNA junction by capping the 5' end of the chromosome. Science (New York, N.Y.). 381: 771-778. PMID 37590346 DOI: 10.1126/science.adi2436  0.435
2023 Moritz L, Schon SB, Rabbani M, Sheng Y, Agrawal R, Glass-Klaiber J, Sultan C, Camarillo JM, Clements J, Baldwin MR, Diehl AG, Boyle AP, O'Brien PJ, Ragunathan K, Hu YC, ... ... Nandakumar J, et al. Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1. Nature Structural & Molecular Biology. PMID 37460896 DOI: 10.1038/s41594-023-01033-4  0.32
2023 Padmanaban S, Tesmer VM, Nandakumar J. Interaction hub critical for telomerase recruitment and primer-template handling for catalysis. Life Science Alliance. 6. PMID 36963832 DOI: 10.26508/lsa.202201727  0.466
2022 Wozniak KJ, Burby PE, Nandakumar J, Simmons LA. Structure and kinase activity of bacterial cell cycle regulator CcrZ. Plos Genetics. 18: e1010196. PMID 35576203 DOI: 10.1371/journal.pgen.1010196  0.364
2022 Brenner KA, Nandakumar J. Consequences of telomere replication failure: the other end-replication problem. Trends in Biochemical Sciences. 47: 506-517. PMID 35440402 DOI: 10.1016/j.tibs.2022.03.013  0.362
2022 Zhang K, Tarczykowska A, Gupta DK, Pendlebury DF, Zuckerman C, Nandakumar J, Shibuya H. The TERB1 MYB domain suppresses telomere erosion in meiotic prophase I. Cell Reports. 38: 110289. PMID 35081355 DOI: 10.1016/j.celrep.2021.110289  0.39
2021 Zhang J, Nandakumar J, Shibuya H. BRCA2 in mammalian meiosis. Trends in Cell Biology. PMID 34625364 DOI: 10.1016/j.tcb.2021.09.003  0.315
2021 Gu P, Jia S, Takasugi T, Tesmer VM, Nandakumar J, Chen Y, Chang S. Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres. Nature Communications. 12: 5514. PMID 34535663 DOI: 10.1038/s41467-021-25799-7  0.408
2021 Pendlebury DF, Zhang J, Agrawal R, Shibuya H, Nandakumar J. Structure of a meiosis-specific complex central to BRCA2 localization at recombination sites. Nature Structural & Molecular Biology. 28: 671-680. PMID 34373645 DOI: 10.1038/s41594-021-00635-0  0.338
2021 Grill S, Padmanaban S, Friedman A, Perkey E, Allen F, Tesmer VM, Chase J, Khoriaty R, Keegan CE, Maillard I, Nandakumar J. TPP1 mutagenesis screens unravel shelterin interfaces and functions in hematopoiesis. Jci Insight. PMID 33822766 DOI: 10.1172/jci.insight.138059  0.347
2020 Zhang J, Gurusaran M, Fujiwara Y, Zhang K, Echbarthi M, Vorontsov E, Guo R, Pendlebury DF, Alam I, Livera G, Emmanuelle M, Wang PJ, Nandakumar J, Davies OR, Shibuya H. The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells. Nature Communications. 11: 2055. PMID 32345962 DOI: 10.1038/S41467-020-15954-X  0.421
2019 Tesmer VM, Smith EM, Danciu O, Padmanaban S, Nandakumar J. Combining conservation and species-specific differences to determine how human telomerase binds telomeres. Proceedings of the National Academy of Sciences of the United States of America. PMID 31822618 DOI: 10.1073/Pnas.1911912116  0.45
2019 Smith EM, Pendlebury DF, Nandakumar J. Structural biology of telomeres and telomerase. Cellular and Molecular Life Sciences : Cmls. PMID 31728577 DOI: 10.1007/S00018-019-03369-X  0.525
2019 Grill S, Bisht K, Tesmer VM, Shami AN, Hammoud SS, Nandakumar J. Two Separation-of-Function Isoforms of Human TPP1 Dictate Telomerase Regulation in Somatic and Germ Cells. Cell Reports. 27: 3511-3521.e7. PMID 31216472 DOI: 10.1016/J.Celrep.2019.05.073  0.399
2018 Gu P, Jia S, Takasugi T, Smith E, Nandakumar J, Hendrickson E, Chang S. CTC1-STN1 coordinates G- and C-strand synthesis to regulate telomere length. Aging Cell. e12783. PMID 29774655 DOI: 10.1111/Acel.12783  0.489
2018 Grill S, Tesmer VM, Nandakumar J. The N Terminus of the OB Domain of Telomere Protein TPP1 Is Critical for Telomerase Action. Cell Reports. 22: 1132-1140. PMID 29386102 DOI: 10.1016/J.Celrep.2018.01.012  0.411
2017 Pendlebury DF, Fujiwara Y, Tesmer VM, Smith EM, Shibuya H, Watanabe Y, Nandakumar J. Dissecting the telomere-inner nuclear membrane interface formed in meiosis. Nature Structural & Molecular Biology. PMID 29083414 DOI: 10.1038/Nsmb.3493  0.41
2017 Bisht K, Grill S, Graniel J, Nandakumar J. A lentivirus-free inducible CRISPR-Cas9 system for efficient targeting of human genes. Analytical Biochemistry. 530: 40-49. PMID 28477963 DOI: 10.1016/J.Ab.2017.05.001  0.401
2016 Gu P, Wang Y, Bisht KK, Wu L, Kukova L, Smith EM, Xiao Y, Bailey SM, Lei M, Nandakumar J, Chang S. Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis. Oncogene. PMID 27869160 DOI: 10.1038/Onc.2016.405  0.471
2016 Bisht K, Smith EM, Tesmer VM, Nandakumar J. Structural and functional consequences of a disease mutation in the telomere protein TPP1. Proceedings of the National Academy of Sciences of the United States of America. PMID 27807141 DOI: 10.1073/Pnas.1605685113  0.376
2016 Jones M, Bisht K, Savage SA, Nandakumar J, Keegan CE, Maillard I. The shelterin complex and hematopoiesis. The Journal of Clinical Investigation. 126: 1621-9. PMID 27135879 DOI: 10.1172/Jci84547  0.46
2014 Kocak H, Ballew BJ, Bisht K, Eggebeen R, Hicks BD, Suman S, O'Neil A, Giri N, Maillard I, Alter BP, Keegan CE, Nandakumar J, Savage SA. Hoyeraal-Hreidarsson syndrome caused by a germline mutation in the TEL patch of the telomere protein TPP1. Genes & Development. 28: 2090-102. PMID 25233904 DOI: 10.1101/Gad.248567.114  0.331
2013 Nakashima M, Nandakumar J, Sullivan KD, Espinosa JM, Cech TR. Inhibition of telomerase recruitment and cancer cell death. The Journal of Biological Chemistry. 288: 33171-80. PMID 24097987 DOI: 10.1074/Jbc.M113.518175  0.35
2013 Nandakumar J, Cech TR. Finding the end: recruitment of telomerase to telomeres. Nature Reviews. Molecular Cell Biology. 14: 69-82. PMID 23299958 DOI: 10.1038/Nrm3505  0.504
2012 Nandakumar J, Bell CF, Weidenfeld I, Zaug AJ, Leinwand LA, Cech TR. The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity. Nature. 492: 285-9. PMID 23103865 DOI: 10.1038/Nature11648  0.532
2012 Nandakumar J, Cech TR. DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe. Nucleic Acids Research. 40: 235-44. PMID 21911358 DOI: 10.1093/Nar/Gkr721  0.559
2010 Zaug AJ, Podell ER, Nandakumar J, Cech TR. Functional interaction between telomere protein TPP1 and telomerase. Genes & Development. 24: 613-22. PMID 20231318 DOI: 10.1101/Gad.1881810  0.506
2010 Nandakumar J, Podell ER, Cech TR. How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA. Proceedings of the National Academy of Sciences of the United States of America. 107: 651-6. PMID 20080730 DOI: 10.1073/Pnas.0911099107  0.562
2008 Nandakumar J, Schwer B, Schaffrath R, Shuman S. RNA repair: an antidote to cytotoxic eukaryal RNA damage. Molecular Cell. 31: 278-86. PMID 18657509 DOI: 10.1016/J.Molcel.2008.05.019  0.454
2007 Nair PA, Nandakumar J, Smith P, Odell M, Lima CD, Shuman S. Structural basis for nick recognition by a minimal pluripotent DNA ligase. Nature Structural & Molecular Biology. 14: 770-8. PMID 17618295 DOI: 10.1038/Nsmb1266  0.621
2007 Wang LK, Nandakumar J, Schwer B, Shuman S. The C-terminal domain of T4 RNA ligase 1 confers specificity for tRNA repair. Rna (New York, N.Y.). 13: 1235-44. PMID 17585047 DOI: 10.1261/Rna.591807  0.474
2007 Keppetipola N, Nandakumar J, Shuman S. Reprogramming the tRNA-splicing activity of a bacterial RNA repair enzyme. Nucleic Acids Research. 35: 3624-30. PMID 17488852 DOI: 10.1093/Nar/Gkm110  0.49
2007 Nandakumar J, Nair PA, Shuman S. Last stop on the road to repair: structure of E. coli DNA ligase bound to nicked DNA-adenylate. Molecular Cell. 26: 257-71. PMID 17466627 DOI: 10.1016/J.Molcel.2007.02.026  0.497
2006 Nandakumar J, Shuman S, Lima CD. RNA ligase structures reveal the basis for RNA specificity and conformational changes that drive ligation forward. Cell. 127: 71-84. PMID 17018278 DOI: 10.1016/J.Cell.2006.08.038  0.635
2006 Zhu H, Nandakumar J, Aniukwu J, Wang LK, Glickman MS, Lima CD, Shuman S. Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D. Proceedings of the National Academy of Sciences of the United States of America. 103: 1711-6. PMID 16446439 DOI: 10.1073/Pnas.0509083103  0.649
2005 Nandakumar J, Shuman S. Dual mechanisms whereby a broken RNA end assists the catalysis of its repair by T4 RNA ligase 2. The Journal of Biological Chemistry. 280: 23484-9. PMID 15851476 DOI: 10.1074/Jbc.M500831200  0.478
2004 Nandakumar J, Shuman S. How an RNA ligase discriminates RNA versus DNA damage. Molecular Cell. 16: 211-21. PMID 15494308 DOI: 10.1016/J.Molcel.2004.09.022  0.554
2004 Nandakumar J, Ho CK, Lima CD, Shuman S. RNA substrate specificity and structure-guided mutational analysis of bacteriophage T4 RNA ligase 2. The Journal of Biological Chemistry. 279: 31337-47. PMID 15084599 DOI: 10.1074/Jbc.M402394200  0.63
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