Randal D. Goff, Ph.D. - Publications

Affiliations: 
2006 Brigham Young University, Provo, UT, United States 
Area:
Organic Chemistry, Immunology

19 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Goff RD, Thorson JS. Neoglycosylation and neoglycorandomization: Enabling tools for the discovery of novel glycosylated bioactive probes and early stage leads. Medchemcomm. 5: 1036-1047. PMID 25071927 DOI: 10.1039/C4Md00117F  0.543
2014 Wang F, Singh S, Zhang J, Huber TD, Helmich KE, Sunkara M, Hurley KA, Goff RD, Bingman CA, Morris AJ, Thorson JS, Phillips GN. Understanding molecular recognition of promiscuity of thermophilic methionine adenosyltransferase sMAT from Sulfolobus solfataricus. The Febs Journal. 281: 4224-39. PMID 24649856 DOI: 10.1111/Febs.12784  0.57
2014 Singh S, Zhang J, Huber TD, Sunkara M, Hurley K, Goff RD, Wang G, Zhang W, Liu C, Rohr J, Van Lanen SG, Morris AJ, Thorson JS. Facile chemoenzymatic strategies for the synthesis and utilization of S-adenosyl-(L)-methionine analogues. Angewandte Chemie (International Ed. in English). 53: 3965-9. PMID 24616228 DOI: 10.1002/Anie.201308272  0.557
2012 Goff RD, Thorson JS. Enhancement of cyclopamine via conjugation with nonmetabolic sugars. Organic Letters. 14: 2454-7. PMID 22540932 DOI: 10.1021/Ol300703Z  0.523
2011 Chang A, Singh S, Helmich KE, Goff RD, Bingman CA, Thorson JS, Phillips GN. Complete set of glycosyltransferase structures in the calicheamicin biosynthetic pathway reveals the origin of regiospecificity. Proceedings of the National Academy of Sciences of the United States of America. 108: 17649-54. PMID 21987796 DOI: 10.1073/Pnas.1108484108  0.603
2011 Singh S, Chang A, Goff RD, Bingman CA, Grüschow S, Sherman DH, Phillips GN, Thorson JS. Structural characterization of the mitomycin 7-O-methyltransferase. Proteins. 79: 2181-8. PMID 21538548 DOI: 10.1002/Prot.23040  0.545
2011 Goff RD, Singh S, Thorson JS. Glycosyloxyamine neoglycosylation: a model study using calicheamicin. Chemmedchem. 6: 774-6. PMID 21520418 DOI: 10.1002/Cmdc.201100028  0.581
2010 Goff RD, Thorson JS. Assessment of chemoselective neoglycosylation methods using chlorambucil as a model. Journal of Medicinal Chemistry. 53: 8129-39. PMID 20973561 DOI: 10.1021/Jm101024J  0.538
2009 Yin N, Long X, Goff RD, Zhou D, Cantu C, Mattner J, Mezard PS, Teyton L, Bendelac A, Savage PB. Alpha anomers of iGb3 and Gb3 stimulate cytokine production by natural killer T cells. Acs Chemical Biology. 4: 199-208. PMID 19175331 DOI: 10.1021/Cb800277N  0.642
2009 Goff RD, Thorson JS. Enhancing the divergent activities of betulinic acid via neoglycosylation. Organic Letters. 11: 461-4. PMID 19102682 DOI: 10.1021/Ol8025704  0.515
2008 Gantt RW, Goff RD, Williams GJ, Thorson JS. Probing the aglycon promiscuity of an engineered glycosyltransferase. Angewandte Chemie (International Ed. in English). 47: 8889-92. PMID 18924204 DOI: 10.1002/Anie.200803508  0.666
2008 Zhang C, Bitto E, Goff RD, Singh S, Bingman CA, Griffith BR, Albermann C, Phillips GN, Thorson JS. Biochemical and structural insights of the early glycosylation steps in calicheamicin biosynthesis. Chemistry & Biology. 15: 842-53. PMID 18721755 DOI: 10.1016/J.Chembiol.2008.06.011  0.699
2008 Williams GJ, Goff RD, Zhang C, Thorson JS. Optimizing glycosyltransferase specificity via "hot spot" saturation mutagenesis presents a catalyst for novobiocin glycorandomization. Chemistry & Biology. 15: 393-401. PMID 18420146 DOI: 10.1016/J.Chembiol.2008.02.017  0.666
2007 Long X, Deng S, Mattner J, Zang Z, Zhou D, McNary N, Goff RD, Teyton L, Bendelac A, Savage PB. Synthesis and evaluation of stimulatory properties of Sphingomonadaceae glycolipids. Nature Chemical Biology. 3: 559-64. PMID 17660835 DOI: 10.1038/Nchembio.2007.19  0.572
2006 Liu Y, Goff RD, Zhou D, Mattner J, Sullivan BA, Khurana A, Cantu C, Ravkov EV, Ibegbu CC, Altman JD, Teyton L, Bendelac A, Savage PB. A modified alpha-galactosyl ceramide for staining and stimulating natural killer T cells. Journal of Immunological Methods. 312: 34-9. PMID 16647712 DOI: 10.1016/j.jim.2006.02.009  0.563
2006 Mattner J, DeBord KL, Ismail N, Goff RD, Cantu C, Zhou D, Saint-Mezard P, Wang V, Gao Y, Yin N, Hoebe K, Schneewind O, Walker D, Beutler B, Teyton L, et al. Correction: Corrigendum: Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections Nature. 439: 502-502. DOI: 10.1038/Nature04475  0.666
2005 Mattner J, Debord KL, Ismail N, Goff RD, Cantu C, Zhou D, Saint-Mezard P, Wang V, Gao Y, Yin N, Hoebe K, Schneewind O, Walker D, Beutler B, Teyton L, et al. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature. 434: 525-9. PMID 15791258 DOI: 10.1038/Nature03408  0.684
2004 Goff RD, Gao Y, Mattner J, Zhou D, Yin N, Cantu C, Teyton L, Bendelac A, Savage PB. Effects of lipid chain lengths in alpha-galactosylceramides on cytokine release by natural killer T cells. Journal of the American Chemical Society. 126: 13602-3. PMID 15493902 DOI: 10.1021/Ja045385Q  0.643
2002 Zhou XT, Forestier C, Goff RD, Li C, Teyton L, Bendelac A, Savage PB. Synthesis and NKT cell stimulating properties of fluorophore- and biotin-appended 6"-amino-6"-deoxy-galactosylceramides. Organic Letters. 4: 1267-70. PMID 11950339 DOI: 10.1021/Ol025565+  0.652
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