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Theresa A. Shapiro - Publications

Affiliations: 
Johns Hopkins University, Baltimore, MD 
Area:
Biochemistry, Molecular Biology
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30 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Meyer KJ, Caton E, Shapiro TA. Model system identifies kinetic driver of Hsp90 inhibitor activity against African trypanosomes and . Antimicrobial Agents and Chemotherapy. PMID 29866861 DOI: 10.1128/Aac.00056-18  0.376
2016 Caton E, Nenortas E, Bakshi RP, Shapiro TA. Hollow-Fiber Methodology for Pharmacokinetic/Pharmacodynamic Studies of Antimalarial Compounds. Current Protocols in Chemical Biology. 8: 29-58. PMID 26995353 DOI: 10.1002/9780470559277.Ch150194  0.325
2015 Tang Girdwood SC, Nenortas E, Shapiro TA. Targeting the gyrase of Plasmodium falciparum with topoisomerase poisons. Biochemical Pharmacology. 95: 227-37. PMID 25881748 DOI: 10.1016/J.Bcp.2015.03.018  0.677
2013 Grab DJ, Nenortas E, Bakshi RP, Nikolskaia OV, Friedman JE, Shapiro TA. Membrane active chelators as novel anti-African trypanosome and anti-malarial drugs. Parasitology International. 62: 461-3. PMID 23811202 DOI: 10.1016/J.Parint.2013.06.009  0.368
2010 Roy Chowdhury A, Bakshi R, Wang J, Yildirir G, Liu B, Pappas-Brown V, Tolun G, Griffith JD, Shapiro TA, Jensen RE, Englund PT. The killing of African trypanosomes by ethidium bromide. Plos Pathogens. 6: e1001226. PMID 21187912 DOI: 10.1371/Journal.Ppat.1001226  0.342
2009 Woodard LE, Mott BT, Singhal V, Kumar N, Shapiro TA, Posner GH. Malaria-Infected Mice Are Cured by a Single Low Dose of a New Silylamide Trioxane Plus Mefloquine. Pharmaceuticals (Basel, Switzerland). 2: 228-235. PMID 27713236 DOI: 10.3390/Ph2030228  0.332
2009 Moon DK, Singhal V, Kumar N, Shapiro TA, Posner GH. Antimalarial Preclinical Drug Development: A Single Oral Dose of A 5-Carbon-linked Trioxane Dimer Plus Mefloquine Cures Malaria-Infected Mice. Drug Development Research. 71: 76-81. PMID 20686674 DOI: 10.1002/Ddr.20350  0.359
2009 Woodard LE, Chang W, Chen X, Liu JO, Shapiro TA, Posner GH. Malaria-infected mice live until at least day 30 after a new monomeric trioxane combined with mefloquine are administered together in a single low oral dose Journal of Medicinal Chemistry. 52: 7458-7462. PMID 19586052 DOI: 10.1021/Jm9005934  0.315
2009 Chen X, Xie S, Bhat S, Kumar N, Shapiro TA, Liu JO. Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo. Chemistry & Biology. 16: 193-202. PMID 19246010 DOI: 10.1016/J.Chembiol.2009.01.006  0.376
2009 Rosenthal AS, Chen X, Liu JO, West DC, Hergenrother PJ, Shapiro TA, Posner GH. Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells. Journal of Medicinal Chemistry. 52: 1198-203. PMID 19186946 DOI: 10.1021/Jm801484V  0.341
2008 Posner GH, Chang W, Hess L, Woodard L, Sinishtaj S, Usera AR, Maio W, Rosenthal AS, Kalinda AS, D'Angelo JG, Petersen KS, Stohler R, Chollet J, Santo-Tomas J, Snyder C, ... ... Shapiro TA, et al. Malaria-infected mice are cured by oral administration of new artemisinin derivatives. Journal of Medicinal Chemistry. 51: 1035-42. PMID 18232653 DOI: 10.1021/Jm701168H  0.338
2007 Posner GH, Paik IH, Chang W, Borstnik K, Sinishtaj S, Rosenthal AS, Shapiro TA. Malaria-infected mice are cured by a single dose of novel artemisinin derivatives Journal of Medicinal Chemistry. 50: 2516-2519. PMID 17439113 DOI: 10.1021/Jm070149M  0.315
2006 Paik IH, Xie S, Shapiro TA, Labonte T, Narducci Sarjeant AA, Baege AC, Posner GH. Second generation, orally active, antimalarial, artemisinin-derived trioxane dimers with high stability, efficacy, and anticancer activity Journal of Medicinal Chemistry. 49: 2731-2734. PMID 16640333 DOI: 10.1021/Jm058288W  0.361
2006 Kulikowicz T, Shapiro TA. Distinct genes encode type II Topoisomerases for the nucleus and mitochondrion in the protozoan parasite Trypanosoma brucei. The Journal of Biological Chemistry. 281: 3048-56. PMID 16316982 DOI: 10.1074/Jbc.M505977200  0.652
2005 Arav-Boger R, Shapiro TA. Molecular mechanisms of resistance in antimalarial chemotherapy: the unmet challenge. Annual Review of Pharmacology and Toxicology. 45: 565-85. PMID 15822189 DOI: 10.1146/Annurev.Pharmtox.45.120403.095946  0.323
2004 Posner GH, McRiner AJ, Paik IH, Sur S, Borstnik K, Xie S, Shapiro TA, Alagbala A, Foster B. Anticancer and antimalarial efficacy and safety of artemisinin-derived trioxane dimers in rodents. Journal of Medicinal Chemistry. 47: 1299-301. PMID 14971910 DOI: 10.1021/Jm0303711  0.311
2003 Nenortas E, Kulikowicz T, Burri C, Shapiro TA. Antitrypanosomal activities of fluoroquinolones with pyrrolidinyl substitutions. Antimicrobial Agents and Chemotherapy. 47: 3015-7. PMID 12937017 DOI: 10.1128/Aac.47.9.3015-3017.2003  0.659
2003 Posner GH, Paik IH, Sur S, McRiner AJ, Borstnik K, Xie S, Shapiro TA. Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy. Journal of Medicinal Chemistry. 46: 1060-5. PMID 12620083 DOI: 10.1021/Jm020461Q  0.346
2002 Borstnik K, Paik IH, Shapiro TA, Posner GH. Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds. International Journal For Parasitology. 32: 1661-7. PMID 12435451 DOI: 10.1016/S0020-7519(02)00195-9  0.362
2002 Posner GH, Jeon HB, Ploypradith P, Paik IH, Borstnik K, Xie S, Shapiro TA. Orally active, water-soluble antimalarial 3-aryltrioxanes: short synthesis and preclinical efficacy testing in rodents. Journal of Medicinal Chemistry. 45: 3824-8. PMID 12190305 DOI: 10.1021/Jm020210H  0.355
2002 Posner GH, Northrop J, Paik IH, Borstnik K, Dolan P, Kensler TW, Xie S, Shapiro TA. New chemical and biological aspects of artemisinin-derived trioxane dimers. Bioorganic & Medicinal Chemistry. 10: 227-32. PMID 11738625 DOI: 10.1016/S0968-0896(01)00270-X  0.32
2000 Posner GH, Maxwell JP, O'Dowd H, Krasavin M, Xie S, Shapiro TA. Antimalarial sulfide, sulfone, and sulfonamide trioxanes. Bioorganic & Medicinal Chemistry. 8: 1361-70. PMID 10896113 DOI: 10.1016/S0968-0896(00)00079-1  0.307
1999 Posner GH, Ploypradith P, Parker MH, O'Dowd H, Woo SH, Northrop J, Krasavin M, Dolan P, Kensler TW, Xie S, Shapiro TA. Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers. Journal of Medicinal Chemistry. 42: 4275-80. PMID 10543871 DOI: 10.1021/Jm990363D  0.347
1998 Bachi MD, Korshin EE, Ploypradith P, Cumming JN, Xie S, Shapiro TA, Posner GH. Synthesis and in vitro antimalarial activity of sulfone endoperoxides. Bioorganic & Medicinal Chemistry Letters. 8: 903-8. PMID 9871509 DOI: 10.1016/S0960-894X(98)00141-3  0.305
1998 Nenortas EC, Bodley AL, Shapiro TA. DNA topoisomerases: a new twist for antiparasitic chemotherapy? Biochimica Et Biophysica Acta. 1400: 349-54. PMID 9748651 DOI: 10.1016/S0167-4781(98)00146-8  0.386
1998 Bodley AL, Cumming JN, Shapiro TA. Effects of camptothecin, a topoisomerase I inhibitor, on Plasmodium falciparum. Biochemical Pharmacology. 55: 709-11. PMID 9515582 DOI: 10.1016/S0006-2952(97)00556-X  0.408
1997 Posner GH, Ploypradith P, Hapangama W, Wang D, Cumming JN, Dolan P, Kensler TW, Klinedinst D, Shapiro TA, Zheng QY, Murray CK, Pilkington LG, Jayasinghe LR, Bray JF, Daughenbaugh R. Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro. Bioorganic & Medicinal Chemistry. 5: 1257-65. PMID 9377085 DOI: 10.1016/S0968-0896(97)00079-5  0.344
1995 Bodley AL, Shapiro TA. Molecular and cytotoxic effects of camptothecin, a topoisomerase I inhibitor, on trypanosomes and Leishmania Proceedings of the National Academy of Sciences of the United States of America. 92: 3726-3730. PMID 7731973 DOI: 10.1073/pnas.92.9.3726  0.315
1988 Ryan KA, Shapiro TA, Rauch CA, Griffith JD, Englund PT. A knotted free minicircle in kinetoplast DNA. Proceedings of the National Academy of Sciences of the United States of America. 85: 5844-8. PMID 2842751 DOI: 10.1073/Pnas.85.16.5844  0.327
1982 Shapiro TA, Talalay P. Schistosoma mansoni: Mechanisms in regulation of glycolysis Experimental Parasitology. 54: 379-390. PMID 7151946 DOI: 10.1016/0014-4894(82)90047-9  0.308
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