Miroslav Styblo - Publications

Affiliations: 
Toxicology University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Toxicology, Analytical Chemistry

68 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Todero J, Douillet C, Shumway AJ, Koller BH, Kanke M, Phuong DJ, Stýblo M, Sethupathy P. Molecular and Metabolic Analysis of Arsenic-Exposed Humanized AS3MT Mice. Environmental Health Perspectives. 131: 127021. PMID 38150313 DOI: 10.1289/EHP12785  0.31
2022 Shang B, Venkatratnam A, Hartwell H, Douillet C, Cable P, Liu T, Zou F, Ideraabdullah FY, Fry RC, Stýblo M. Ex vivo exposures to arsenite and its methylated trivalent metabolites alter gene transcription in mouse sperm cells. Toxicology and Applied Pharmacology. 455: 116266. PMID 36209798 DOI: 10.1016/j.taap.2022.116266  0.322
2022 Clark J, Bommarito P, Stýblo M, Rubio-Andrade M, García-Vargas GG, Gamble MV, Fry RC. Maternal serum concentrations of one-carbon metabolism factors modify the association between biomarkers of arsenic methylation efficiency and birth weight. Environmental Health : a Global Access Science Source. 21: 68. PMID 35836250 DOI: 10.1186/s12940-022-00875-7  0.311
2021 Stýblo M, Venkatratnam A, Fry RC, Thomas DJ. Origins, fate, and actions of methylated trivalent metabolites of inorganic arsenic: progress and prospects. Archives of Toxicology. PMID 33768354 DOI: 10.1007/s00204-021-03028-w  0.381
2020 Douillet C, Koller B, Styblo M. Metabolism of inorganic arsenic in mice lacking genes encoding GST-P, GST-M, and GST-T. Chemical Research in Toxicology. PMID 32700902 DOI: 10.1021/Acs.Chemrestox.0C00273  0.348
2020 Li YY, Douillet C, Huang M, Beck R, Sumner SJ, Styblo M. Exposure to inorganic arsenic and its methylated metabolites alters metabolomics profiles in INS-1 832/13 insulinoma cells and isolated pancreatic islets. Archives of Toxicology. PMID 32277266 DOI: 10.1007/S00204-020-02729-Y  0.398
2017 Murko M, Elek B, Styblo M, Thomas DJ, Francesconi KA. Dose and diet - Sources of arsenic intake in mouse in utero exposure scenarios. Chemical Research in Toxicology. PMID 29244955 DOI: 10.1021/Acs.Chemrestox.7B00309  0.373
2017 Beck R, Styblo M, Sethupathy P. Arsenic Exposure and Type 2 Diabetes: MicroRNAs as Mechanistic Links? Current Diabetes Reports. 17: 18. PMID 28275977 DOI: 10.1007/S11892-017-0845-8  0.382
2016 Currier JM, Douillet C, Drobná Z, Stýblo M. Oxidation state specific analysis of arsenic species in tissues of wild-type and arsenic (+3 oxidation state) methyltransferase-knockout mice. Journal of Environmental Sciences (China). 49: 104-112. PMID 28007165 DOI: 10.1016/J.Jes.2016.06.018  0.736
2016 Grau-Pérez M, Kuo CC, Spratlen M, Thayer KA, Mendez MA, Hamman RF, Dabelea D, Adgate JL, Knowler WC, Bell RA, Miller FW, Liese AD, Zhang C, Douillet C, Drobná Z, ... ... Styblo M, et al. The Association of Arsenic Exposure and Metabolism With Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study. Diabetes Care. PMID 27810988 DOI: 10.2337/Dc16-0810  0.343
2016 Hudgens EE, Drobna Z, He B, Le XC, Styblo M, Rogers J, Thomas DJ. Biological and behavioral factors modify urinary arsenic metabolic profiles in a U.S. population. Environmental Health : a Global Access Science Source. 15: 62. PMID 27230915 DOI: 10.1186/S12940-016-0144-X  0.426
2015 Rager JE, Tilley SK, Tulenko SE, Smeester L, Ray PD, Yosim A, Currier JM, Ishida MC, González-Horta Mdel C, Sánchez-Ramírez B, Ballinas-Casarrubias L, Gutiérrez-Torres DS, Drobná Z, Del Razo LM, García-Vargas GG, et al. Identification of Novel Gene Targets and Putative Regulators of Arsenic-Associated DNA Methylation in Human Urothelial Cells and Bladder Cancer. Chemical Research in Toxicology. 28: 1144-55. PMID 26039340 DOI: 10.1021/Tx500393Y  0.738
2014 Musil S, Matoušek T, Currier JM, Stýblo M, Dědina J. Speciation analysis of arsenic by selective hydride generation-cryotrapping-atomic fluorescence spectrometry with flame-in-gas-shield atomizer: achieving extremely low detection limits with inexpensive instrumentation. Analytical Chemistry. 86: 10422-8. PMID 25300934 DOI: 10.1021/Ac502931K  0.707
2014 Currier JM, Ishida MC, González-Horta C, Sánchez-Ramírez B, Ballinas-Casarrubias L, Gutiérrez-Torres DS, Cerón RH, Morales DV, Terrazas FA, Del Razo LM, García-Vargas GG, Saunders RJ, Drobná Z, Fry RC, Matoušek T, et al. Associations between arsenic species in exfoliated urothelial cells and prevalence of diabetes among residents of Chihuahua, Mexico. Environmental Health Perspectives. 122: 1088-94. PMID 25000461 DOI: 10.1289/Ehp.1307756  0.724
2014 Lu K, Mahbub R, Cable PH, Ru H, Parry NM, Bodnar WM, Wishnok JS, Styblo M, Swenberg JA, Fox JG, Tannenbaum SR. Gut microbiome phenotypes driven by host genetics affect arsenic metabolism. Chemical Research in Toxicology. 27: 172-4. PMID 24490651 DOI: 10.1021/Tx400454Z  0.346
2013 Lu K, Cable PH, Abo RP, Ru H, Graffam ME, Schlieper KA, Parry NM, Levine S, Bodnar WM, Wishnok JS, Styblo M, Swenberg JA, Fox JG, Tannenbaum SR. Gut microbiome perturbations induced by bacterial infection affect arsenic biotransformation. Chemical Research in Toxicology. 26: 1893-903. PMID 24134150 DOI: 10.1021/Tx4002868  0.439
2013 Matoušek T, Currier JM, Trojánková N, Saunders RJ, Ishida MC, González-Horta C, Musil S, Mester Z, Stýblo M, Dědina J. Selective hydride generation- cryotrapping- ICP-MS for arsenic speciation analysis at picogram levels: analysis of river and sea water reference materials and human bladder epithelial cells. Journal of Analytical Atomic Spectrometry. 28: 1456-1465. PMID 24014931 DOI: 10.1039/C3Ja50021G  0.735
2013 Currier J, Saunders RJ, Ding L, Bodnar W, Cable P, Matoušek T, Creed JT, Stýblo M. Comparative oxidation state specific analysis of arsenic species by high-performance liquid chromatography-inductively coupled plasma-mass spectrometry and hydride generation-cryotrapping-atomic absorption spectrometry. Journal of Analytical Atomic Spectrometry. 28: 843-852. PMID 23687401 DOI: 10.1039/C3Ja30380B  0.76
2013 Bailey KA, Wu MC, Ward WO, Smeester L, Rager JE, García-Vargas G, Del Razo LM, Drobná Z, Stýblo M, Fry RC. Arsenic and the epigenome: interindividual differences in arsenic metabolism related to distinct patterns of DNA methylation. Journal of Biochemical and Molecular Toxicology. 27: 106-15. PMID 23315758 DOI: 10.1002/Jbt.21462  0.354
2013 Ghiuzeli CM, Calabro A, Saunders RJ, Budman DR, Styblo M, Devoe CE, Allen SL. Arsenic trioxide: Pharmacokinetics in acute promyelocytic leukemia (APL) patients. Journal of Clinical Oncology. 31: 7055-7055. DOI: 10.1200/Jco.2013.31.15_Suppl.7055  0.377
2011 Currier JM, Svoboda M, Matoušek T, Dědina J, Stýblo M. Direct analysis and stability of methylated trivalent arsenic metabolites in cells and tissues. Metallomics : Integrated Biometal Science. 3: 1347-54. PMID 22015847 DOI: 10.1039/C1Mt00095K  0.754
2011 Del Razo LM, García-Vargas GG, Valenzuela OL, Castellanos EH, Sánchez-Peña LC, Currier JM, Drobná Z, Loomis D, Stýblo M. Exposure to arsenic in drinking water is associated with increased prevalence of diabetes: a cross-sectional study in the Zimapán and Lagunera regions in Mexico. Environmental Health : a Global Access Science Source. 10: 73. PMID 21864395 DOI: 10.1186/1476-069X-10-73  0.731
2011 Currier JM, Svoboda M, de Moraes DP, Matousek T, Dĕdina J, Stýblo M. Direct analysis of methylated trivalent arsenicals in mouse liver by hydride generation-cryotrapping-atomic absorption spectrometry. Chemical Research in Toxicology. 24: 478-80. PMID 21361335 DOI: 10.1021/Tx200060C  0.759
2010 Drobna Z, Styblo M, Thomas DJ. Manipulation of expression of arsenic (+3 oxidation state) methyltransferase in cultured cells. Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (Editor-in-Chief) ... [Et Al.]. Unit 4.35. PMID 20949432 DOI: 10.1002/0471140856.Tx0435S43  0.391
2010 Hughes MF, Edwards BC, Herbin-Davis KM, Saunders J, Styblo M, Thomas DJ. Arsenic (+3 oxidation state) methyltransferase genotype affects steady-state distribution and clearance of arsenic in arsenate-treated mice. Toxicology and Applied Pharmacology. 249: 217-23. PMID 20887743 DOI: 10.1016/J.Taap.2010.09.017  0.374
2010 Drobná Z, Walton FS, Harmon AW, Thomas DJ, Stýblo M. Interspecies differences in metabolism of arsenic by cultured primary hepatocytes. Toxicology and Applied Pharmacology. 245: 47-56. PMID 20138079 DOI: 10.1016/J.Taap.2010.01.015  0.333
2009 Drobna Z, Styblo M, Thomas DJ. An Overview of Arsenic Metabolism and Toxicity. Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (Editor-in-Chief) ... [Et Al.]. 42: 4.31.1-4.31.6. PMID 25419261 DOI: 10.1002/0471140856.Tx0431S42  0.436
2009 Drobna Z, Styblo M, Thomas DJ. Purification of arsenic (+3 oxidation state) methyltransferase from rat liver cytosol. Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (Editor-in-Chief) ... [Et Al.]. Unit4.34. PMID 20949431 DOI: 10.1002/0471140856.Tx0434S42  0.4
2009 Drobna Z, Styblo M, Thomas DJ. In vitro assays of inorganic arsenic methylation. Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (Editor-in-Chief) ... [Et Al.]. 42: 4.32.1-4.32.10. PMID 20440380 DOI: 10.1002/0471140856.Tx0432S42  0.423
2009 Hernandez-Zavala A, Drobna Z, Styblo M, Thomas DJ. Analysis of arsenical metabolites in biological samples. Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (Editor-in-Chief) ... [Et Al.]. 42: 4.33.1-4.33.17. PMID 20396652 DOI: 10.1002/0471140856.Tx0433S42  0.402
2009 Kojima C, Ramirez DC, Tokar EJ, Himeno S, Drobná Z, Stýblo M, Mason RP, Waalkes MP. Requirement of arsenic biomethylation for oxidative DNA damage. Journal of the National Cancer Institute. 101: 1670-81. PMID 19933942 DOI: 10.1093/Jnci/Djp414  0.34
2009 Drobna Z, Naranmandura H, Kubachka KM, Edwards BC, Herbin-Davis K, Styblo M, Le XC, Creed JT, Maeda N, Hughes MF, Thomas DJ. Disruption of the arsenic (+3 oxidation state) methyltransferase gene in the mouse alters the phenotype for methylation of arsenic and affects distribution and retention of orally administered arsenate. Chemical Research in Toxicology. 22: 1713-20. PMID 19691357 DOI: 10.1021/Tx900179R  0.445
2008 Hernández-Zavala A, Matoušek T, Drobná Z, Paul DS, Walton F, Adair BM, Jiří D, Thomas DJ, Stýblo M. Speciation analysis of arsenic in biological matrices by automated hydride generation-cryotrapping-atomic absorption spectrometry with multiple microflame quartz tube atomizer (multiatomizer). Journal of Analytical Atomic Spectrometry. 23: 342-351. PMID 18677417 DOI: 10.1039/b706144g  0.386
2008 Pi J, Diwan BA, Sun Y, Liu J, Qu W, He Y, Styblo M, Waalkes MP. Arsenic-induced malignant transformation of human keratinocytes: involvement of Nrf2. Free Radical Biology & Medicine. 45: 651-8. PMID 18572023 DOI: 10.1016/J.Freeradbiomed.2008.05.020  0.333
2008 Matoušek T, Hernández-Zavala A, Svoboda M, Langrová L, Adair BM, Drobná Z, Thomas DJ, Stýblo M, Dědina J. Oxidation State Specific Generation of Arsines from Methylated Arsenicals Based on L- Cysteine Treatment in Buffered Media for Speciation Analysis by Hydride Generation - Automated Cryotrapping - Gas Chromatography-Atomic Absorption Spectrometry with the Multiatomizer. Spectrochimica Acta. Part B: Atomic Spectroscopy. 63: 396-406. PMID 18521190 DOI: 10.1016/j.sab.2007.11.037  0.32
2008 Hughes MF, Devesa V, Adair BM, Conklin SD, Creed JT, Styblo M, Kenyon EM, Thomas DJ. Tissue dosimetry, metabolism and excretion of pentavalent and trivalent dimethylated arsenic in mice after oral administration. Toxicology and Applied Pharmacology. 227: 26-35. PMID 18036629 DOI: 10.1016/J.Taap.2007.10.011  0.353
2007 Paul DS, Hernández-Zavala A, Walton FS, Adair BM, Dedina J, Matousek T, Stýblo M. Examination of the effects of arsenic on glucose homeostasis in cell culture and animal studies: development of a mouse model for arsenic-induced diabetes. Toxicology and Applied Pharmacology. 222: 305-14. PMID 17336358 DOI: 10.1016/j.taap.2007.01.010  0.312
2007 Thomas DJ, Li J, Waters SB, Xing W, Adair BM, Drobna Z, Devesa V, Styblo M. Arsenic (+3 oxidation state) methyltransferase and the methylation of arsenicals. Experimental Biology and Medicine (Maywood, N.J.). 232: 3-13. PMID 17202581 DOI: 10.3181/00379727-207-2320003  0.438
2006 Drobna Z, Xing W, Thomas DJ, Stýblo M. shRNA silencing of AS3MT expression minimizes arsenic methylation capacity of HepG2 cells. Chemical Research in Toxicology. 19: 894-8. PMID 16841956 DOI: 10.1021/tx060076u  0.321
2006 Devesa V, Adair BM, Liu J, Waalkes MP, Diwan BA, Styblo M, Thomas DJ. Arsenicals in maternal and fetal mouse tissues after gestational exposure to arsenite. Toxicology. 224: 147-55. PMID 16753250 DOI: 10.1016/J.Tox.2006.04.041  0.402
2006 Liu Z, Styblo M, Rosen BP. Methylarsonous acid transport by aquaglyceroporins. Environmental Health Perspectives. 114: 527-31. PMID 16581540 DOI: 10.1289/Ehp.8600  0.411
2005 Benbrahim-Tallaa L, Waterland RA, Styblo M, Achanzar WE, Webber MM, Waalkes MP. Molecular events associated with arsenic-induced malignant transformation of human prostatic epithelial cells: aberrant genomic DNA methylation and K-ras oncogene activation. Toxicology and Applied Pharmacology. 206: 288-98. PMID 16039940 DOI: 10.1016/J.Taap.2004.11.017  0.322
2005 Li J, Waters SB, Drobna Z, Devesa V, Styblo M, Thomas DJ. Arsenic (+3 oxidation state) methyltransferase and the inorganic arsenic methylation phenotype. Toxicology and Applied Pharmacology. 204: 164-9. PMID 15808521 DOI: 10.1016/J.Taap.2004.12.002  0.471
2005 Adair BM, Waters SB, Devesa V, Drobna Z, Styblo M, Thomas DJ. Commonalities in Metabolism of Arsenicals Environmental Chemistry. 2: 161. DOI: 10.1071/En05054  0.472
2004 Waters SB, Devesa V, Fricke MW, Creed JT, Stýblo M, Thomas DJ. Glutathione modulates recombinant rat arsenic (+3 oxidation state) methyltransferase-catalyzed formation of trimethylarsine oxide and trimethylarsine. Chemical Research in Toxicology. 17: 1621-9. PMID 15606138 DOI: 10.1021/tx0497853  0.322
2004 Drobná Z, Waters SB, Walton FS, LeCluyse EL, Thomas DJ, Stýblo M. Interindividual variation in the metabolism of arsenic in cultured primary human hepatocytes. Toxicology and Applied Pharmacology. 201: 166-77. PMID 15541756 DOI: 10.1016/J.Taap.2004.05.004  0.351
2004 Walton FS, Harmon AW, Paul DS, Drobná Z, Patel YM, Styblo M. Inhibition of insulin-dependent glucose uptake by trivalent arsenicals: possible mechanism of arsenic-induced diabetes. Toxicology and Applied Pharmacology. 198: 424-33. PMID 15276423 DOI: 10.1016/J.Taap.2003.10.026  0.31
2004 Thomas DJ, Waters SB, Styblo M. Elucidating the pathway for arsenic methylation. Toxicology and Applied Pharmacology. 198: 319-26. PMID 15276411 DOI: 10.1016/J.Taap.2003.10.020  0.459
2004 Waters SB, Devesa V, Del Razo LM, Styblo M, Thomas DJ. Endogenous reductants support the catalytic function of recombinant rat cyt19, an arsenic methyltransferase. Chemical Research in Toxicology. 17: 404-9. PMID 15025511 DOI: 10.1021/Tx0342161  0.402
2003 Mure K, Uddin AN, Lopez LC, Styblo M, Rossman TG. Arsenite induces delayed mutagenesis and transformation in human osteosarcoma cells at extremely low concentrations. Environmental and Molecular Mutagenesis. 41: 322-31. PMID 12802802 DOI: 10.1002/Em.10164  0.346
2003 Walton FS, Waters SB, Jolley SL, LeCluyse EL, Thomas DJ, Styblo M. Selenium compounds modulate the activity of recombinant rat AsIII-methyltransferase and the methylation of arsenite by rat and human hepatocytes. Chemical Research in Toxicology. 16: 261-5. PMID 12641425 DOI: 10.1021/Tx025649R  0.389
2002 Easterling MR, Styblo M, Evans MV, Kenyon EM. Pharmacokinetic modeling of arsenite uptake and metabolism in hepatocytes--mechanistic insights and implications for further experiments. Journal of Pharmacokinetics and Pharmacodynamics. 29: 207-34. PMID 12449496 DOI: 10.1023/A:1020248922689  0.366
2002 Stýblo M, Drobná Z, Jaspers I, Lin S, Thomas DJ. The role of biomethylation in toxicity and carcinogenicity of arsenic: a research update. Environmental Health Perspectives. 110: 767-71. PMID 12426129 DOI: 10.1289/Ehp.110-1241242  0.363
2002 Lin S, Shi Q, Nix FB, Styblo M, Beck MA, Herbin-Davis KM, Hall LL, Simeonsson JB, Thomas DJ. A novel S-adenosyl-L-methionine:arsenic(III) methyltransferase from rat liver cytosol. The Journal of Biological Chemistry. 277: 10795-803. PMID 11790780 DOI: 10.1074/Jbc.M110246200  0.425
2001 Thomas DJ, Styblo M, Lin S. The cellular metabolism and systemic toxicity of arsenic. Toxicology and Applied Pharmacology. 176: 127-144. PMID 11601889 DOI: 10.1006/Taap.2001.9258  0.499
2001 Del Razo LM, Styblo M, Cullen WR, Thomas DJ. Determination of trivalent methylated arsenicals in biological matrices. Toxicology and Applied Pharmacology. 174: 282-93. PMID 11485389 DOI: 10.1006/Taap.2001.9226  0.495
2001 Vega L, Styblo M, Patterson R, Cullen W, Wang C, Germolec D. Differential effects of trivalent and pentavalent arsenicals on cell proliferation and cytokine secretion in normal human epidermal keratinocytes. Toxicology and Applied Pharmacology. 172: 225-32. PMID 11312651 DOI: 10.1006/Taap.2001.9152  0.445
2001 Mass MJ, Tennant A, Roop BC, Cullen WR, Styblo M, Thomas DJ, Kligerman AD. Methylated trivalent arsenic species are genotoxic. Chemical Research in Toxicology. 14: 355-61. PMID 11304123 DOI: 10.1021/Tx000251L  0.378
2001 Styblo M, Thomas DJ. Selenium modifies the metabolism and toxicity of arsenic in primary rat hepatocytes Toxicology and Applied Pharmacology. 172: 52-61. PMID 11264023 DOI: 10.1006/Taap.2001.9134  0.431
2001 Lin S, Del Razo LM, Styblo M, Wang C, Cullen WR, Thomas DJ. Arsenicals inhibit thioredoxin reductase in cultured rat hepatocytes. Chemical Research in Toxicology. 14: 305-11. PMID 11258980 DOI: 10.1021/Tx0001878  0.37
2000 Styblo M, Del Razo LM, Vega L, Germolec DR, LeCluyse EL, Hamilton GA, Reed W, Wang C, Cullen WR, Thomas DJ. Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells. Archives of Toxicology. 74: 289-99. PMID 11005674 DOI: 10.1007/S002040000134  0.475
1999 Styblo M, Del Razo LM, LeCluyse EL, Hamilton GA, Wang C, Cullen WR, Thomas DJ. Metabolism of arsenic in primary cultures of human and rat hepatocytes. Chemical Research in Toxicology. 12: 560-5. PMID 10409394 DOI: 10.1021/Tx990050L  0.45
1997 Hall LL, George SE, Kohan MJ, Styblo M, Thomas DJ. In vitro methylation of inorganic arsenic in mouse intestinal cecum. Toxicology and Applied Pharmacology. 147: 101-109. PMID 9356312 DOI: 10.1006/Taap.1997.8269  0.408
1997 Styblo M, Thomas DJ. Binding of arsenicals to proteins in an in vitro methylation system Toxicology and Applied Pharmacology. 147: 1-8. PMID 9356301 DOI: 10.1006/Taap.1997.8256  0.349
1996 Styblo M, Hughes MF, Thomas DJ. Liberation and analysis of protein-bound arsenicals. Journal of Chromatography B: Biomedical Sciences and Applications. 677: 161-166. PMID 8925090 DOI: 10.1016/0378-4347(95)00490-4  0.38
1996 Styblo M, Delnomdedieu M, Thomas DJ. Mono- and dimethylation of arsenic in rat liver cytosol in vitro Chemico-Biological Interactions. 99: 147-164. PMID 8620564 DOI: 10.1016/0009-2797(95)03666-0  0.377
1995 Styblo M, Yamauchi H, Thomas DJ. Comparative in vitro methylation of trivalent and pentavalent arsenicals. Toxicology and Applied Pharmacology. 135: 172-178. PMID 8545824 DOI: 10.1006/Taap.1995.1220  0.479
1994 Delnomdedieu M, Basti MM, Styblo M, Otvos JD, Thomas DJ. Complexation of arsenic species in rabbit erythrocytes. Chemical Research in Toxicology. 7: 621-627. PMID 7841340 DOI: 10.1021/Tx00041A006  0.304
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