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Hilaire C. Lam, Ph.D. - Publications

Affiliations: 
2011 University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Pathology, Medicine and Surgery, Toxicology, Cell Biology
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28 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Champion JD, Dodd KM, Lam HC, Alzahrani MAM, Seifan S, Rad E, Scourfield DO, Fishel ML, Calver BL, Ager A, Henske EP, Davies DM, Kelley MR, Tee AR. Drug Inhibition of Redox Factor-1 Restores Hypoxia-Driven Changes in Tuberous Sclerosis Complex 2 Deficient Cells. Cancers. 14. PMID 36551683 DOI: 10.3390/cancers14246195  0.328
2022 Zhang L, Hobeika CS, Khabibullin D, Yu D, Filippakis H, Alchoueiry M, Tang Y, Lam HC, Tsvetkov P, Georgiou G, Lamb C, Stone E, Puigserver P, Priolo C, Henske EP. Hypersensitivity to ferroptosis in chromophobe RCC is mediated by a glutathione metabolic dependency and cystine import via solute carrier family 7 member 11. Proceedings of the National Academy of Sciences of the United States of America. 119: e2122840119. PMID 35867762 DOI: 10.1073/pnas.2122840119  0.304
2021 Alesi N, Akl EW, Khabibullin D, Liu HJ, Nidhiry AS, Garner ER, Filippakis H, Lam HC, Shi W, Viswanathan SR, Morroni M, Ferguson SM, Henske EP. TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism. Nature Communications. 12: 4245. PMID 34253722 DOI: 10.1038/s41467-021-24499-6  0.376
2021 Kosmas K, Filippakis H, Khabibullin D, Turkiewicz M, Lam HC, Yu J, Kedersha NL, Anderson PJ, Henske EP. TSC2 Interacts with HDLBP/Vigilin and Regulates Stress Granule Formation. Molecular Cancer Research : McR. PMID 33888601 DOI: 10.1158/1541-7786.MCR-20-1046  0.377
2021 Kovalenko A, Sanin A, Kosmas K, Zhang L, Wang J, Akl EW, Giannikou K, Probst CK, Hougard TR, Rue RW, Krymskaya VP, Asara JM, Lam HC, Kwiatkowski DJ, Henske EP, et al. Therapeutic targeting of DGKA-mediated macropinocytosis leads to phospholipid reprogramming in Tuberous Sclerosis Complex. Cancer Research. PMID 33593821 DOI: 10.1158/0008-5472.CAN-20-2218  0.344
2019 Zarei M, Du H, Nassar AH, Yan RE, Giannikou K, Johnson SH, Lam HC, Henske EP, Wang Y, Zhang T, Asara J, Kwiatkowski DJ. Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion. The Journal of Experimental Medicine. PMID 31506280 DOI: 10.1084/Jem.20190251  0.44
2019 Liu HJ, Lam HC, Baglini CV, Nijmeh J, Cottrill AA, Chan SY, Henske EP. Rapamycin-upregulated miR-29b promotes mTORC1-hyperactive cell growth in TSC2-deficient cells by downregulating tumor suppressor retinoic acid receptor β (RARβ). Oncogene. PMID 31420607 DOI: 10.1038/S41388-019-0957-5  0.385
2018 Filippakis H, Belaid A, Siroky B, Wu C, Alesi N, Hougard T, Nijmeh J, Lam HC, Henske EP. Vps34-mediated macropinocytosis in Tuberous Sclerosis Complex 2-deficient cells supports tumorigenesis. Scientific Reports. 8: 14161. PMID 30242175 DOI: 10.1038/S41598-018-32256-X  0.46
2018 Lam HC, Siroky BJ, Henske EP. Renal disease in tuberous sclerosis complex: pathogenesis and therapy. Nature Reviews. Nephrology. PMID 30232410 DOI: 10.1038/S41581-018-0059-6  0.388
2018 Liu HJ, Lizotte PH, Du H, Speranza MC, Lam HC, Vaughan S, Alesi N, Wong KK, Freeman GJ, Sharpe AH, Henske EP. TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy. Jci Insight. 3. PMID 29669930 DOI: 10.1172/Jci.Insight.98674  0.362
2018 Ogórek B, Lam HC, Khabibullin D, Liu HJ, Nijmeh J, Triboulet R, Kwiatkowski DJ, Gregory RI, Henske EP. TSC2 Regulates microRNA Biogenesis via mTORC1 and GSK3β. Human Molecular Genetics. PMID 29509898 DOI: 10.1093/Hmg/Ddy073  0.474
2017 Valvezan AJ, Turner M, Belaid A, Lam HC, Miller SK, McNamara MC, Baglini C, Housden BE, Perrimon N, Kwiatkowski DJ, Asara JM, Henske EP, Manning BD. mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability. Cancer Cell. PMID 29056426 DOI: 10.1016/J.Ccell.2017.09.013  0.384
2017 Lam HC, Liu HJ, Baglini CV, Filippakis H, Alesi N, Nijmeh J, Du H, Lope AL, Cottrill KA, Handen A, Asara JM, Kwiatkowski DJ, Ben-Sahra I, Oldham WM, Chan SY, et al. Rapamycin-induced miR-21 promotes mitochondrial homeostasis and adaptation in mTORC1 activated cells. Oncotarget. 8: 64714-64727. PMID 29029388 DOI: 10.18632/Oncotarget.19947  0.397
2017 Lam HC, Baglini CV, Llorente Lope A, Parkhitko A, Liu HJ, Alesi N, Malinowska IA, Ebrahimi-Fakhari D, Saffari A, Yu JJ, Pereira A, Khabibullin D, Ogorek B, Nijmeh JS, Kavanagh T, et al. p62/SQSTM1 cooperates with hyperactive mTORC1 to regulate glutathione production, maintain mitochondrial integrity and promote tumorigenesis. Cancer Research. PMID 28512249 DOI: 10.1158/0008-5472.Can-16-2458  0.399
2017 Belaid A, Filippakis H, Lam H, Valvezan A, Huang R, Xia M, Wen T, Baglini C, Sakamuru S, Asara J, Sinh NT, Heard JJ, Tamanoi F, Austin C, Manning B, et al. Abstract A09: Therapeutic targeting of TSC2-deficient cells with Methotrexate: Results of a drug repurposing screen Clinical Cancer Research. 23. DOI: 10.1158/1557-3265.Pmccavuln16-A09  0.439
2016 Ren S, Luo Y, Chen H, Warburton D, Lam HC, Wang L, Chen P, Henske EP, Shi W. Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization. The American Journal of Pathology. PMID 27768862 DOI: 10.1016/J.Ajpath.2016.08.013  0.42
2016 Lam HC, Nijmeh JS, Henske EP. New developments in the genetics and pathogenesis of tumours in tuberous sclerosis complex. The Journal of Pathology. PMID 27753446 DOI: 10.1002/Path.4827  0.343
2016 Lam HC, Parkhitko A, Lope AL, Alesi N, Khabibullin D, Filippakis H, Pereira A, Ogorek B, Zhang E, Yu J, Priolo C, Henske EP. Abstract A35: Regulation of the tumor microenvironment by oncogenic p62 in mTORC1-hyperactive diseases: Tuberous sclerosis complex (TSC) and lymphangioleiomyomatosis (LAM) Cancer Research. 76. DOI: 10.1158/1538-7445.Tme16-A35  0.444
2016 Lam HC, Filippakis H, Cottrill KA, Lope AL, Khabibullin D, Priolo C, Ogorek B, Chan SY, Pereira A, Henske EP. Abstract B12: Rapamycin-induced miR-21 promotes the survival of mTORC1 hyperactivated cells in tuberous sclerosis complex models Cancer Research. 76. DOI: 10.1158/1538-7445.Nonrna15-B12  0.356
2014 Liang N, Zhang C, Dill P, Panasyuk G, Pion D, Koka V, Gallazzini M, Olson EN, Lam H, Henske EP, Dong Z, Apte U, Pallet N, Johnson RL, Terzi F, et al. Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex. The Journal of Experimental Medicine. 211: 2249-63. PMID 25288394 DOI: 10.1084/Jem.20140341  0.488
2014 Siempos II, Lam HC, Ding Y, Choi ME, Choi AM, Ryter SW. Cecal ligation and puncture-induced sepsis as a model to study autophagy in mice. Journal of Visualized Experiments : Jove. e51066. PMID 24561344 DOI: 10.3791/51066  0.344
2014 Cloonan SM, Lam HC, Ryter SW, Choi AM. "Ciliophagy": The consumption of cilia components by autophagy. Autophagy. 10: 532-4. PMID 24401596 DOI: 10.4161/Auto.27641  0.427
2013 Lam HC, Cloonan SM, Bhashyam AR, Haspel JA, Singh A, Sathirapongsasuti JF, Cervo M, Yao H, Chung AL, Mizumura K, An CH, Shan B, Franks JM, Haley KJ, Owen CA, et al. Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction. The Journal of Clinical Investigation. 123: 5212-30. PMID 24200693 DOI: 10.1172/Jci69636  0.426
2013 Lam HC, Trindade AJ, Medvetz DA, Yu J, Priolo C, Chan SY, Henske EP. Abstract A35: Identification of pro-survival rapamycin-dependent microRNA (Rapa-miRs) in tuberous sclerosis complex Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-A35  0.362
2012 An CH, Wang XM, Lam HC, Ifedigbo E, Washko GR, Ryter SW, Choi AM. TLR4 deficiency promotes autophagy during cigarette smoke-induced pulmonary emphysema. American Journal of Physiology. Lung Cellular and Molecular Physiology. 303: L748-57. PMID 22983353 DOI: 10.1152/Ajplung.00102.2012  0.311
2011 Lam HC, Choi AM, Ryter SW. Isolation of mouse respiratory epithelial cells and exposure to experimental cigarette smoke at air liquid interface. Journal of Visualized Experiments : Jove. PMID 21372793 DOI: 10.3791/2513  0.325
2011 Ryter SW, Lam HC, Chen ZH, Choi AM. Deadly triplex: smoke, autophagy and apoptosis. Autophagy. 7: 436-7. PMID 21200154 DOI: 10.4161/Auto.7.4.14501  0.421
2010 Chen ZH, Lam HC, Jin Y, Kim HP, Cao J, Lee SJ, Ifedigbo E, Parameswaran H, Ryter SW, Choi AM. Autophagy protein microtubule-associated protein 1 light chain-3B (LC3B) activates extrinsic apoptosis during cigarette smoke-induced emphysema. Proceedings of the National Academy of Sciences of the United States of America. 107: 18880-5. PMID 20956295 DOI: 10.1073/Pnas.1005574107  0.428
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