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Ya-Huei Kuo, Ph.D. - Publications

Affiliations: 
2001 University of Connecticut, Storrs, CT, United States 
Area:
Cell Biology, Molecular Biology
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55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Dong H, He X, Zhang L, Chen W, Lin YC, Liu SB, Wang H, Nguyen LXT, Li M, Zhu Y, Zhao D, Ghoda L, Serody J, Vincent B, Luznik L, ... ... Kuo YH, et al. Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity. Nature Cancer. PMID 38413714 DOI: 10.1038/s43018-024-00736-x  0.332
2022 Wang H, He X, Zhang L, Dong H, Huang F, Xian J, Li M, Chen W, Lu X, Pathak KV, Huang W, Li Z, Zhang L, Nguyen LXT, Yang L, ... ... Kuo YH, et al. Disruption of dNTPs Homeostasis by Ribonucleotide Reductase Hyperactivation Overcomes AML Differentiation Blockade. Blood. PMID 35439288 DOI: 10.1182/blood.2021015108  0.366
2021 Zhang B, Nguyen LXT, Zhao D, Frankhouser DE, Wang H, Hoang DH, Qiao J, Abundis C, Brehove M, Su YL, Feng Y, Stein A, Ghoda L, Dorrance A, Perrotti D, ... ... Kuo YH, et al. Treatment-induced arteriolar revascularization and miR-126 enhancement in bone marrow niche protect leukemic stem cells in AML. Journal of Hematology & Oncology. 14: 122. PMID 34372909 DOI: 10.1186/s13045-021-01133-y  0.318
2020 Rockne RC, Branciamore S, Qi J, Frankhouser DE, O'Meally D, Hua WK, Cook G, Carnahan E, Zhang L, Marom A, Wu H, Maestrini D, Wu X, Yuan YC, Liu Z, ... ... Kuo YH, et al. State-transition analysis of time-sequential gene expression identifies critical points that predict development of acute myeloid leukemia. Cancer Research. PMID 32414754 DOI: 10.1158/0008-5472.Can-20-0354  0.357
2020 Nguyen DQ, Hoang DH, Nelson M, Nigam L, Nguyen VTT, Zhang L, Pham TKT, Ho HD, Nguyen DDT, Lam TQ, Tat TT, Elhajmoussa Y, Ly QT, Pichiorri F, Pullarkat V, ... ... Kuo YH, et al. Requirement of GTP binding for TIF-90-regulated ribosomal RNA synthesis and oncogenic activities in human colon cancer cells. Journal of Cellular Physiology. PMID 32159236 DOI: 10.1002/Jcp.29661  0.4
2019 Wang H, Zhao D, Nguyen LX, Wu H, Li L, Dong D, Troadec E, Zhu Y, Hoang DH, Stein AS, Al Malki M, Aldoss I, Lin A, Ghoda LY, McDonald T, ... ... Kuo YH, et al. Targeting cell membrane HDM2: A novel therapeutic approach for acute myeloid leukemia. Leukemia. PMID 31337857 DOI: 10.1038/s41375-019-0522-9  0.411
2019 He X, Zhu Y, Lin YC, Li M, Du J, Dong H, Sun J, Zhu L, Wang H, Ding Z, Zhang L, Zhang L, Zhao D, Wang Z, Wu H, ... ... Kuo YH, et al. PRMT1-mediated FLT3 arginine methylation promotes maintenance of FLT3-ITD Acute Myeloid Leukemia. Blood. PMID 31217189 DOI: 10.1182/Blood.2019001282  0.487
2019 Wang H, Sun J, Zhao D, Tong H, Wu H, Li X, Luo Y, Dong D, McDonald T, Stein A, Malki MMA, Pichiorri F, Carlesso N, Kuo Y, Zhang B, et al. Targeting MiR-126 Blocks Progression of Myelodysplastic Syndrome and Transformation into Acute Myeloid Leukemia Blood. 134: 1707-1707. DOI: 10.1182/Blood-2019-130375  0.337
2019 Qiao J, Zhao D, Nguyen LXT, Wu H, Liu G, Suo S, Wang H, Elhajmoussa Y, Liang C, Snyder D, Ali H, Rosen S, Carlesso N, Li L, Kuo Y, et al. Spred1 Insufficiency in the Hematopoietic and/or Vascular Compartments of the Bone Marrow (BM) Niche Promotes Aggressive Leukemogenesis in Chronic Myelogenous Leukemia (CML) Blood. 134: 3791-3791. DOI: 10.1182/Blood-2019-127616  0.354
2019 Wu D, Li M, Zhang L, Qi J, Chen CD, He X, Zhu Y, Dong H, Sun J, Li L, Marcucci G, Kuo Y. HDAC8 Promotes MLL-Rearranged Acute Myeloid Leukemia By Inhibiting p53 Acetylation Blood. 134: 642-642. DOI: 10.1182/Blood-2019-124134  0.427
2019 Zhang L, Nguyen LXT, Wu D, Brewer CJ, He X, Li M, Zhao D, Cook GJ, Qi J, Wu H, Zhang B, Li L, Kortylewski M, Marcucci G, Kuo Y. Anti-MiR-126 Therapy for Inv(16) Acute Myeloid Leukemia Blood. 134: 3914-3914. DOI: 10.1182/Blood-2019-123468  0.3
2018 Sun J, He X, Zhu Y, Ding Z, Dong H, Feng Y, Du J, Wang H, Wu X, Zhang L, Yu X, Lin A, McDonald T, Zhao D, Wu H, ... ... Kuo YH, et al. SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function. Cell Stem Cell. PMID 30146412 DOI: 10.1016/J.Stem.2018.07.018  0.387
2018 Wang H, Zhang B, Wang W, Zhao D, Li L, Wu H, Nguyen LXT, Meng W, McDonald T, Pichiorri F, Kuo Y, Chen J, Carlesso N, Aldoss I, Pullarkat VA, et al. Downregulation of Mir-142 Promotes Leukemia Growth in Philadelphia Chromosome-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL): A Possible Novel Therapeutic Target? Blood. 132: 1338-1338. DOI: 10.1182/Blood-2018-99-119599  0.364
2018 Zhu Y, He X, Dong H, Sun J, Wang H, Zhang L, Miao Y, Jin J, Shen Y, Chen J, Muschen M, Chen C, Konopleva MY, Sun W, Zhang B, ... Kuo Y, et al. Inhibition of PRMT1 Mediated FLT3 Arginine Methylation As a Potent Therapeutic Strategy for MLL-r ALL Blood. 132: 892-892. DOI: 10.1182/Blood-2018-99-115139  0.318
2018 He X, Zhu Y, Dong H, Li SM, Ding Z, Sun J, Du J, Wang H, Zhang L, Shen Y, Su H, Khaled SK, Zhao D, Zhang L, Hickey R, ... ... Kuo Y, et al. PRMT1 Mediated FLT3 Methylation As a Therapeutic Vulnerability in FLT3-ITD+ AML Blood. 132: 760-760. DOI: 10.1182/Blood-2018-99-112766  0.314
2017 Hua WK, Qi J, Cai Q, Carnahan E, Ayala Ramirez M, Li L, Marcucci G, Kuo YH. HDAC8 regulates long-term hematopoietic stem cell maintenance under stress by modulating p53 activity. Blood. PMID 29084772 DOI: 10.1182/Blood-2017-03-771386  0.475
2017 Kumar B, Garcia M, Weng L, Jung X, Murakami JL, Hu X, McDonald T, Lin A, Kumar AR, DiGiusto DL, Stein AS, Pullarkat VA, Hui SK, Carlesso N, Kuo YH, et al. Acute myeloid leukemia transforms the bone marrow niche into a leukemia-permissive microenvironment through exosome secretion. Leukemia. PMID 28816238 DOI: 10.1038/Leu.2017.259  0.471
2017 Gupta PD, Lu B, Li H, Li Z, Zhao X, Kuo Y, Kortylewski M. TLR9 triggering/STAT3 inhibition to reprogram leukemic cells into antigen-presenting cells and trigger T-cell responses. Journal of Clinical Oncology. 35: 118-118. DOI: 10.1200/Jco.2017.35.7_Suppl.118  0.449
2016 Cai Q, Jeannet R, Hua WK, Cook GJ, Zhang B, Qi J, Liu H, Li L, Chen CC, Marcucci G, Kuo YH. CBFβ-SMMHC creates aberrant megakaryocyte-erythroid progenitors prone to leukemia-initiation in mice. Blood. PMID 27443289 DOI: 10.1182/Blood-2016-01-693119  0.541
2016 Kuo YH, Qi J, Cook GJ. Regain control of p53: targeting leukemia stem cells by isoform-specific HDAC inhibition. Experimental Hematology. PMID 26923266 DOI: 10.1016/J.Exphem.2016.02.007  0.477
2016 Zhang Q, Hossain DM, Duttagupta P, Moreira D, Zhao X, Won H, Buettner R, Nechaev S, Majka M, Zhang B, Cai Q, Swiderski P, Kuo YH, Forman S, Marcucci G, et al. Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia. Blood. PMID 26796361 DOI: 10.1182/Blood-2015-08-665604  0.459
2016 Qi J, Cook GJ, Zhang B, Hua W, Qi C, Carnahan E, Marom A, Nguyen LXT, Lu Y, Branciamore S, Wu H, Yuan Y, Wu X, Li L, Stein AS, ... ... Kuo Y, et al. Time Sequential Transcriptome Analysis Identifies Mir-126 As an Early Biomarker for Inv(16) Acute Myeloid Leukemia (AML) Disease Progression Blood. 128: 773-773. DOI: 10.1182/Blood.V128.22.773.773  0.373
2016 Hua W, Qi J, Cai Q, Carnahan E, Li L, Ngo VN, Marcucci G, Kuo Y. HDAC8 Regulates Long-Term Hematopoietic Stem Cell Quiescence and Maintenance Blood. 128: 1468-1468. DOI: 10.1182/Blood.V128.22.1468.1468  0.489
2016 Sun J, Zhu Y, Ding Z, Dong H, Feng Y, Chen Q, Yu X, Zhao D, Wu H, Feng L, Tohyama K, Oberdoerffer P, Zhang B, Kuo Y, Bhatia R, et al. TET2 Activity Is Modulated By SIRT1-Mediated Protein Deacetylation: A Potential Therapeutic Target in Myelodysplastic Syndrome Blood. 128: 1053-1053. DOI: 10.1182/Blood.V128.22.1053.1053  0.497
2015 Qi J, Singh S, Hua WK, Cai Q, Chao SW, Li L, Liu H, Ho Y, McDonald T, Lin A, Marcucci G, Bhatia R, Huang WJ, Chang CI, Kuo YH. HDAC8 Inhibition Specifically Targets Inv(16) Acute Myeloid Leukemic Stem Cells by Restoring p53 Acetylation. Cell Stem Cell. PMID 26387755 DOI: 10.1016/j.stem.2015.08.004  0.409
2015 Zhang B, Li L, Chen C, Stein AS, Ali H, Snyder DS, Lin A, Dorrance A, Swiderski P, Bhatia R, Perrotti D, Forman SJ, Kuo Y, Kortylewski M, Marcucci G. Knockdown (KD) of Mir-126 Expression Enhances Tyrosine Kinase Inhibitor (TKI)-Mediated Targeting of Chronic Myelogenous Leukemia (CML) Stem Cells Blood. 126: 51-51. DOI: 10.1182/Blood.V126.23.51.51  0.376
2014 Kuo YH, Bhatia R. Pushing the limits: defeating leukemia stem cells by depleting telomerase. Cell Stem Cell. 15: 673-5. PMID 25479742 DOI: 10.1016/J.Stem.2014.11.014  0.457
2014 Li L, Osdal T, Ho Y, Chun S, McDonald T, Agarwal P, Lin A, Chu S, Qi J, Li L, Hsieh YT, Dos Santos C, Yuan H, Ha TQ, Popa M, ... ... Kuo YH, et al. SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells. Cell Stem Cell. 15: 431-46. PMID 25280219 DOI: 10.1016/J.Stem.2014.08.001  0.526
2014 Kortylewski M, Kuo YH. Push and release: TLR9 activation plus STAT3 blockade for systemic antitumor immunity. Oncoimmunology. 3: e27441. PMID 24800162 DOI: 10.4161/Onci.27441  0.339
2014 Hossain DM, Dos Santos C, Zhang Q, Kozlowska A, Liu H, Gao C, Moreira D, Swiderski P, Jozwiak A, Kline J, Forman S, Bhatia R, Kuo YH, Kortylewski M. Leukemia cell-targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity. Blood. 123: 15-25. PMID 24169824 DOI: 10.1182/blood-2013-07-517987  0.302
2014 Zhang Q, Hossain DMS, Nechaev S, Buettner R, Swiderski P, Jozwiak A, Forman SJ, Bhatia R, Kuo Y, Kortylewski M. Systemic delivery of TLR9-activating/STAT3-blocking oligonucleotides induces leukemia regression Journal For Immunotherapy of Cancer. 2: 107. DOI: 10.1186/2051-1426-2-S3-P107  0.322
2014 Qi J, Cai Q, Singh S, Li L, Liu H, McDonald T, Lin A, Bhatia R, Huang w, Chang c, Kuo y. Inhibition of HDAC8 Reactivates p53 and Abrogates Leukemia Stem Cell Activity in CBFβ-SMMHC Associated Acute Myeloid Leukemia Blood. 124: 363-363. DOI: 10.1182/Blood.V124.21.363.363  0.472
2014 Cai Q, Jeannet R, Liu H, Kuo y. CBFβ-SMMHC Impairs Erythroid Differentiation and Induces Expansion of Aberrant Megakaryocytic/Erythroid Progenitors Capable of Leukemia Initiation Blood. 124: 2149-2149. DOI: 10.1182/Blood.V124.21.2149.2149  0.556
2013 Dos Santos C, McDonald T, Ho YW, Liu H, Lin A, Forman SJ, Kuo YH, Bhatia R. The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents. Blood. 122: 1900-13. PMID 23896410 DOI: 10.1182/Blood-2012-11-466425  0.521
2013 Jeannet R, Cai Q, Liu H, Vu H, Kuo YH. Alcam regulates long-term hematopoietic stem cell engraftment and self-renewal. Stem Cells (Dayton, Ohio). 31: 560-71. PMID 23280653 DOI: 10.1002/Stem.1309  0.441
2013 Hossain DMS, Santos CD, Zhang Q, Kozlowska A, Liu H, Gao C, Moreira D, Swiderski P, Jozwiak A, Kline J, Forman SJ, Bhatia R, Kuo Y, Kortylewski M. In Vivo Targeting Of Acute Myeloid Leukemia Using CpG-Stat3 siRNA Results In T Cell-Dependent Tumor Eradication Blood. 122: 4212-4212. DOI: 10.1182/Blood.V122.21.4212.4212  0.442
2013 Agarwal P, Tinisha M, Lin A, Forman SJ, Kuo Y, Bhatia R. Selective Anti Leukemic Activity Of Low Dose Decitabine In Combination With Ruxolitinib Against Stem/Progenitor Cells From Elderly AML Patients Blood. 122: 2690-2690. DOI: 10.1182/Blood.V122.21.2690.2690  0.363
2013 Qi J, Singh S, Cai Q, Li L, Liu H, Vu H, Huang w, McDonald T, Lin A, Chang c, Bhatia R, Kuo Y. Selective Targeting Of Inv(16)+ AML Stem Progenitor Cells By Inhibiting HDAC8 Blood. 122: 224-224. DOI: 10.1182/Blood.V122.21.224.224  0.5
2013 Cai Q, Jeannet R, Liu H, Kuo Y. Aberrant Megakaryocytic/Erythroid Progenitors Contributes To Transformation Of Cbfb-SMMHC Induced Acute Myeloid Leukemia Blood. 122: 1652-1652. DOI: 10.1182/Blood.V122.21.1652.1652  0.561
2013 Hossain SDM, Santos CD, Zhang Q, Liu H, Swiderski P, Kowolik C, Forman S, Bhatia R, Kuo Y, Kortylewski M. Abstract LB-334: CpG-STAT3siRNA for two-pronged immunotherapy of acute myeloid leukemia . Cancer Research. 73. DOI: 10.1158/1538-7445.Am2013-Lb-334  0.47
2012 Pulikkan JA, Madera D, Xue L, Bradley P, Landrette SF, Kuo YH, Abbas S, Zhu LJ, Valk P, Castilla LH. Thrombopoietin/MPL participates in initiating and maintaining RUNX1-ETO acute myeloid leukemia via PI3K/AKT signaling. Blood. 120: 868-79. PMID 22613795 DOI: 10.1182/Blood-2012-03-414649  0.684
2012 Qi J, Singh S, Cai Q, Liu H, Vu H, Balasubramanian S, Kuo Y. CBFβ-SMMHC Inactivates p53 Tumor Suppressor Through Aberrant Protein Interaction and Recruitment of HDAC8 Blood. 120: 772-772. DOI: 10.1182/Blood.V120.21.772.772  0.396
2012 Jeannet R, Cai Q, Liu H, Vu H, Kuo Y. Alcam Mediated Interaction Regulates Normal Hematopoietic Stem Cell Function and Cbfβ-SMMHC Induced Leukemogenesis Blood. 120: 4091-4091. DOI: 10.1182/Blood.V120.21.4091.4091  0.51
2011 Santos CED, Li L, McDonald T, Li L, Lin A, Kuo Y, Bhatia R. Src Kinase Inhibition by Dasatinib Enhances Targeting of Human AML Stem/Progenitor Cells by Chemotherapeutic Agents Blood. 118: 4270-4270. DOI: 10.1182/Blood.V118.21.4270.4270  0.401
2011 Jeannet R, Cai Q, Liu H, Vu H, Kuo Y. Alcam Mediated Cellular Interaction Regulates Hematopoietic Stem Cell Repopulation and Self-Renewal Blood. 118: 1291-1291. DOI: 10.1182/Blood.V118.21.1291.1291  0.47
2010 Santos CED, McDonald T, Li L, Lin A, Kuo Y, Bhatia R. SFK Inhibition with Dasatinib Results In Selective Targeting of Primitive Human Acute Myeloid Leukemia Stem and Progenitor Cells. Blood. 116: 1053-1053. DOI: 10.1182/Blood.V116.21.1053.1053  0.372
2009 Kuo YH, Zaidi SK, Gornostaeva S, Komori T, Stein GS, Castilla LH. Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice. Blood. 113: 3323-32. PMID 19179305 DOI: 10.1182/Blood-2008-06-162248  0.763
2008 Kuo YH, Gerstein RM, Castilla LH. Cbfbeta-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development. Blood. 111: 1543-51. PMID 17940206 DOI: 10.1182/Blood-2007-07-104422  0.705
2006 Heilman SA, Kuo YH, Goudswaard CS, Valk PJ, Castilla LH. Cbfbeta reduces Cbfbeta-SMMHC-associated acute myeloid leukemia in mice. Cancer Research. 66: 11214-8. PMID 17145866 DOI: 10.1158/0008-5472.Can-06-0959  0.76
2006 Kuo YH, Landrette SF, Heilman SA, Perrat PN, Garrett L, Liu PP, Le Beau MM, Kogan SC, Castilla LH. Cbf beta-SMMHC induces distinct abnormal myeloid progenitors able to develop acute myeloid leukemia. Cancer Cell. 9: 57-68. PMID 16413472 DOI: 10.1016/J.Ccr.2005.12.014  0.759
2005 Landrette SF, Kuo YH, Hensen K, Barjesteh van Waalwijk van Doorn-Khosrovani S, Perrat PN, Van de Ven WJ, Delwel R, Castilla LH. Plag1 and Plagl2 are oncogenes that induce acute myeloid leukemia in cooperation with Cbfb-MYH11. Blood. 105: 2900-7. PMID 15585652 DOI: 10.1182/Blood-2004-09-3630  0.753
2004 Kuo Y, Heilman S, Chen A, Liu PP, Gernstein R, Kogan S, Castilla LH. Cbfb-MYH11 Induces Expansion of a Lin-Kit+Sca1- Abnormal Progenitor Compartment that Predisposes Acute Myeloid Leukemia in Mice. Blood. 104: 543-543. DOI: 10.1182/Blood.V104.11.543.543  0.743
2003 Kuo YH, Chen TT. Specific cell surface binding sites shared by human Pro-IGF-I Eb-peptides and rainbow trout Pro-IGF-I Ea-4-peptide. General and Comparative Endocrinology. 132: 231-40. PMID 12812770 DOI: 10.1016/S0016-6480(03)00089-3  0.543
2002 Kuo YH, Chen TT. Novel activities of pro-IGF-I E peptides: Regulation of morphological differentiation and anchorage-independent growth in human neuroblastoma cells Experimental Cell Research. 280: 75-89. PMID 12372341 DOI: 10.1006/Excr.2002.5628  0.549
2002 Chen MJ, Kuo YH, Tian XC, Chen TT. Novel biological activities of the fish pro-IGF-I E-peptides: studies on effects of fish pro-IGF-I E-peptide on morphological change, anchorage-dependent cell division, and invasiveness in tumor cells. General and Comparative Endocrinology. 126: 342-51. PMID 12093122 DOI: 10.1016/S0016-6480(02)00010-2  0.586
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