Stephen Townley Holgate - Publications

Affiliations: 
University of Southampton, Southampton, England, United Kingdom 

147 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Agache I, Canelo-Aybar C, Annesi-Maesano I, Cecchi L, Biagioni B, Chung F, D'Amato G, Damialis A, Del Giacco S, De Las Vecillas L, Dominguez-Ortega J, Galàn C, Gilles S, Giovannini M, Holgate S, et al. The impact of indoor pollution on asthma-related outcomes: A systematic review for the EAACI guidelines on environmental science for allergic diseases and asthma. Allergy. PMID 38366695 DOI: 10.1111/all.16051  0.453
2024 Agache I, Canelo-Aybar C, Annesi-Maesano I, Cecchi L, Rigau D, Rodríguez-Tanta LY, Nieto-Gutierrez W, Song Y, Cantero-Fortiz Y, Roqué M, Vasquez JC, Sola I, Biagioni B, Chung F, D'Amato G, ... ... Holgate S, et al. The impact of outdoor pollution and extreme temperatures on asthma-related outcomes: A systematic review for the EAACI guidelines on environmental science for allergic diseases and asthma. Allergy. PMID 38311978 DOI: 10.1111/all.16041  0.457
2023 Annesi-Maesano I, Cecchi L, Benedetta B, Chung KF, Clot B, Collaud Coen M, D'Amato G, Damialis A, Dominguez-Ortega J, Galàn C, Gilles S, Holgate S, Jeebhay M, Kazadzis S, Papadopoulos NG, et al. Is exposure to pollen a risk factor for moderate and severe asthma exacerbations? Allergy. PMID 36961370 DOI: 10.1111/all.15724  0.449
2021 Ali H, Brooks C, Crane J, Beasley R, Holgate S, Gibson P, Pattemore P, Tzeng YC, Stanley T, Pearce N, Douwes J. Enhanced airway sensory nerve reactivity in non-eosinophilic asthma. Bmj Open Respiratory Research. 8. PMID 34728474 DOI: 10.1136/bmjresp-2021-000974  0.456
2020 Humbert M, Bourdin A, Papadopoulos NG, Holgate ST, Hanania NA, Halpin DMG, Chapman KR, Gavornikova M, Price DB, Kaplan A, Heaney LG. Reducing the hidden burden of severe asthma: Recognition and referrals from primary practice. The Journal of Asthma : Official Journal of the Association For the Care of Asthma. 1-9. PMID 32347748 DOI: 10.1080/02770903.2020.1759084  0.479
2020 Bachert C, Humbert M, Hanania NA, Zhang N, Holgate S, Buhl R, Bröker BM. and its IgE-inducing Enterotoxins in Asthma: Current Knowledge. The European Respiratory Journal. PMID 31980492 DOI: 10.1183/13993003.01592-2019  0.499
2019 Busse WW, Humbert M, Haselkorn T, Ortiz B, Trzaskoma BL, Stephenson P, Conde LG, Kianifard F, Holgate ST. Effect of omalizumab on lung function and eosinophil levels in adolescents with moderate-to-severe allergic asthma. Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology. PMID 31760132 DOI: 10.1016/j.anai.2019.11.016  0.367
2019 Holgate ST, Walker S, West B, Boycott K. The Future of Asthma Care: Personalized Asthma Treatment. Clinics in Chest Medicine. 40: 227-241. PMID 30691714 DOI: 10.1016/j.ccm.2018.10.013  0.5
2019 Holgate S. The use of pharmacogenetics in the treatment of asthma. Personalized Medicine. 2: 197-201. PMID 29793259 DOI: 10.2217/17410541.2.3.197  0.374
2017 Bruton A, Lee A, Yardley L, Raftery J, Arden-Close E, Kirby S, Zhu S, Thiruvothiyur M, Webley F, Taylor L, Gibson D, Yao G, Stafford-Watson M, Versnel J, Moore M, ... ... Holgate ST, et al. Physiotherapy breathing retraining for asthma: a randomised controlled trial. The Lancet. Respiratory Medicine. PMID 29248433 DOI: 10.1016/S2213-2600(17)30474-5  0.325
2017 Thomas M, Bruton A, Little P, Holgate S, Lee A, Yardley L, George S, Raftery J, Versnel J, Price D, Pavord I, Djukanovic R, Moore M, Kirby S, Yao G, et al. A randomised controlled study of the effectiveness of breathing retraining exercises taught by a physiotherapist either by instructional DVD or in face-to-face sessions in the management of asthma in adults. Health Technology Assessment (Winchester, England). 21: 1-162. PMID 28944752 DOI: 10.3310/hta21530  0.327
2017 Buhl R, Humbert M, Bjermer L, Chanez P, Heaney LG, Pavord I, Quirce S, Virchow JC, Holgate S. Severe eosinophilic asthma: a roadmap to consensus. The European Respiratory Journal. 49. PMID 28461308 DOI: 10.1183/13993003.00634-2017  0.511
2017 Masefield S, Edwards J, Hansen K, Hamerlijnck D, Lisspers K, van der Schee M, Silva L, Matthews J, Gaga M, Adcock I, Holgate S, Walker S, Powell P. The future of asthma research and development: a roadmap from the European Asthma Research and Innovation Partnership (EARIP). The European Respiratory Journal. 49. PMID 28461297 DOI: 10.1183/13993003.02295-2016  0.463
2016 Davies ER, Kelly JF, Howarth PH, Wilson DI, Holgate ST, Davies DE, Whitsett JA, Haitchi HM. Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life. Jci Insight. 1. PMID 27489884 DOI: 10.1172/jci.insight.87632  0.545
2016 An SS, Mitzner W, Tang WY, Ahn K, Yoon AR, Huang J, Kilic O, Yong HM, Fahey JW, Kumar S, Biswal S, Holgate ST, Panettieri RA, Solway J, Liggett SB. An inflammation-independent contraction mechanophenotype of airway smooth muscle in asthma. The Journal of Allergy and Clinical Immunology. PMID 26936804 DOI: 10.1016/J.Jaci.2015.12.1315  0.4
2016 Agusti A, Bel E, Thomas M, Vogelmeier C, Brusselle G, Holgate S, Humbert M, Jones P, Gibson PG, Vestbo J, Beasley R, Pavord ID. Treatable traits: toward precision medicine of chronic airway diseases. The European Respiratory Journal. 47: 410-9. PMID 26828055 DOI: 10.1183/13993003.01359-2015  0.398
2016 Malerba M, D Amato M, Radaeli A, Giacovelli G, Rovati L, Arshad SH, Holgate ST. Efficacy of Andolast in Mild to Moderate Asthma: A Randomized, Controlled, Double-Blind Multicenter Study (The Andast Trial). Current Pharmaceutical Design. 21: 3835-43. PMID 25845448 DOI: 10.2174/1381612821666150407101614  0.315
2015 Holgate ST, Wenzel S, Postma DS, Weiss ST, Renz H, Sly PD. Asthma. Nature Reviews. Disease Primers. 1: 15025. PMID 27189668 DOI: 10.1038/nrdp.2015.25  0.561
2015 Busse WW, Holgate ST, Wenzel SW, Klekotka P, Chon Y, Feng J, Ingenito E, Nirula A. Biomarker Profiles in Asthma with High vs. Low Airway Reversibility and Poor Disease Control. Chest. PMID 26226215 DOI: 10.1378/chest.14-2457  0.477
2015 D'Amato G, Holgate ST, Pawankar R, Ledford DK, Cecchi L, Al-Ahmad M, Al-Enezi F, Al-Muhsen S, Ansotegui I, Baena-Cagnani CE, Baker DJ, Bayram H, Bergmann KC, Boulet LP, Buters JT, et al. Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the World Allergy Organization. The World Allergy Organization Journal. 8: 25. PMID 26207160 DOI: 10.1186/S40413-015-0073-0  0.319
2015 Pavord ID, Bush A, Holgate S. Asthma diagnosis: addressing the challenges. The Lancet. Respiratory Medicine. 3: 339-41. PMID 25753861 DOI: 10.1016/S2213-2600(15)00056-9  0.478
2015 Edwards J, Belvisi M, Dahlen SE, Holgate S, Holmes A. Human tissue models for a human disease: what are the barriers? Thorax. 70: 695-7. PMID 25631322 DOI: 10.1136/thoraxjnl-2014-206648  0.441
2014 Martinez-Nunez RT, Bondanese VP, Louafi F, Francisco-Garcia AS, Rupani H, Bedke N, Holgate S, Howarth PH, Davies DE, Sanchez-Elsner T. A microRNA network dysregulated in asthma controls IL-6 production in bronchial epithelial cells. Plos One. 9: e111659. PMID 25360780 DOI: 10.1371/journal.pone.0111659  0.315
2014 Humbert M, Busse W, Hanania NA, Lowe PJ, Canvin J, Erpenbeck VJ, Holgate S. Omalizumab in asthma: an update on recent developments. The Journal of Allergy and Clinical Immunology. in Practice. 2: 525-36.e1. PMID 25213045 DOI: 10.1016/j.jaip.2014.03.010  0.455
2014 Mauri P, Riccio AM, Rossi R, Di Silvestre D, Benazzi L, De Ferrari L, Dal Negro RW, Holgate ST, Canonica GW. Proteomics of bronchial biopsies: galectin-3 as a predictive biomarker of airway remodelling modulation in omalizumab-treated severe asthma patients. Immunology Letters. 162: 2-10. PMID 25194755 DOI: 10.1016/j.imlet.2014.08.010  0.471
2014 Yáñez A, Cho SH, Soriano JB, Rosenwasser LJ, Rodrigo GJ, Rabe KF, Peters S, Niimi A, Ledford DK, Katial R, Fabbri LM, Celedón JC, Canonica GW, Busse P, Boulet LP, ... ... Holgate ST, et al. Asthma in the elderly: what we know and what we have yet to know. The World Allergy Organization Journal. 7: 8. PMID 25152804 DOI: 10.1186/1939-4551-7-8  0.501
2014 Holgate ST. New strategies with anti-IgE in allergic diseases. The World Allergy Organization Journal. 7: 17. PMID 25097719 DOI: 10.1186/1939-4551-7-17  0.389
2014 Djukanovi? R, Harrison T, Johnston SL, Gabbay F, Wark P, Thomson NC, Niven R, Singh D, Reddel HK, Davies DE, Marsden R, Boxall C, Dudley S, Plagnol V, Holgate ST, et al. The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial. American Journal of Respiratory and Critical Care Medicine. 190: 145-54. PMID 24937476 DOI: 10.1164/Rccm.201312-2235Oc  0.417
2014 Aryan Z, Holgate ST, Radzioch D, Rezaei N. A new era of targeting the ancient gatekeepers of the immune system: toll-like agonists in the treatment of allergic rhinitis and asthma. International Archives of Allergy and Immunology. 164: 46-63. PMID 24853609 DOI: 10.1159/000362553  0.307
2014 Meyers DA, Bleecker ER, Holloway JW, Holgate ST. Asthma genetics and personalised medicine. The Lancet. Respiratory Medicine. 2: 405-15. PMID 24794577 DOI: 10.1016/S2213-2600(14)70012-8  0.522
2013 Busse WW, Holgate S, Kerwin E, Chon Y, Feng J, Lin J, Lin SL. Randomized, double-blind, placebo-controlled study of brodalumab, a human anti-IL-17 receptor monoclonal antibody, in moderate to severe asthma. American Journal of Respiratory and Critical Care Medicine. 188: 1294-302. PMID 24200404 DOI: 10.1164/rccm.201212-2318OC  0.353
2013 Holgate ST. Mechanisms of asthma and implications for its prevention and treatment: a personal journey. Allergy, Asthma & Immunology Research. 5: 343-7. PMID 24179679 DOI: 10.4168/aair.2013.5.6.343  0.549
2013 Leino MS, Loxham M, Blume C, Swindle EJ, Jayasekera NP, Dennison PW, Shamji BW, Edwards MJ, Holgate ST, Howarth PH, Davies DE. Barrier disrupting effects of alternaria alternata extract on bronchial epithelium from asthmatic donors. Plos One. 8: e71278. PMID 24009658 DOI: 10.1371/journal.pone.0071278  0.353
2013 Holgate ST. Immune circuits in asthma. Current Opinion in Pharmacology. 13: 345-50. PMID 23639506 DOI: 10.1016/j.coph.2013.03.008  0.442
2013 Manuyakorn W, Howarth PH, Holgate ST. Airway remodelling in asthma and novel therapy. Asian Pacific Journal of Allergy and Immunology. 31: 3-10. PMID 23517388  0.463
2013 Caruso M, Crisafulli E, Demma S, Holgate S, Polosa R. Disabling inflammatory pathways with biologics and resulting clinical outcomes in severe asthma. Expert Opinion On Biological Therapy. 13: 393-402. PMID 23289846 DOI: 10.1517/14712598.2013.743989  0.397
2013 Nambu M, Holgate S. Differences in the asthma treatment of children between europe and Japan: a questionnaire-based survey using model cases. The World Allergy Organization Journal. 2: 54-6. PMID 23282981 DOI: 10.1097/WOX.0b013e31819f20eb  0.426
2013 Holgate ST. Stratified approaches to the treatment of asthma. British Journal of Clinical Pharmacology. 76: 277-91. PMID 23163316 DOI: 10.1111/bcp.12036  0.493
2012 Gowers AM, Cullinan P, Ayres JG, Anderson HR, Strachan DP, Holgate ST, Mills IC, Maynard RL. Does outdoor air pollution induce new cases of asthma? Biological plausibility and evidence; a review. Respirology (Carlton, Vic.). 17: 887-98. PMID 22672711 DOI: 10.1111/j.1440-1843.2012.02195.x  0.388
2012 Wang C, Rose-Zerilli MJ, Koppelman GH, Sandling JK, Holloway JW, Postma DS, Holgate ST, Bours V, Syvänen AC, Dideberg V. Evidence of association between interferon regulatory factor 5 gene polymorphisms and asthma. Gene. 504: 220-5. PMID 22613848 DOI: 10.1016/j.gene.2012.05.021  0.473
2012 Holgate ST. Innate and adaptive immune responses in asthma. Nature Medicine. 18: 673-83. PMID 22561831 DOI: 10.1038/nm.2731  0.364
2012 Hallstrand TS, Woodruff PG, Holgate ST, Knight DA. Function of the airway epithelium in asthma. Journal of Allergy. 2012: 160586. PMID 22536273 DOI: 10.1155/2012/160586  0.497
2012 Holgate ST. Trials and tribulations in identifying new biologic treatments for asthma. Trends in Immunology. 33: 238-46. PMID 22436378 DOI: 10.1016/j.it.2012.02.003  0.492
2012 Pawankar R, Canonica GW, Holgate ST, Lockey RF. Allergic diseases and asthma: a major global health concern. Current Opinion in Allergy and Clinical Immunology. 12: 39-41. PMID 22157151 DOI: 10.1097/ACI.0b013e32834ec13b  0.451
2011 Holgate ST. Pathophysiology of asthma: what has our current understanding taught us about new therapeutic approaches? The Journal of Allergy and Clinical Immunology. 128: 495-505. PMID 21807404 DOI: 10.1016/j.jaci.2011.06.052  0.484
2011 Bjornsdottir US, Holgate ST, Reddy PS, Hill AA, McKee CM, Csimma CI, Weaver AA, Legault HM, Small CG, Ramsey RC, Ellis DK, Burke CM, Thompson PJ, Howarth PH, Wardlaw AJ, et al. Pathways activated during human asthma exacerbation as revealed by gene expression patterns in blood. Plos One. 6: e21902. PMID 21779351 DOI: 10.1371/journal.pone.0021902  0.479
2011 Xiao C, Puddicombe SM, Field S, Haywood J, Broughton-Head V, Puxeddu I, Haitchi HM, Vernon-Wilson E, Sammut D, Bedke N, Cremin C, Sones J, Djukanovi? R, Howarth PH, Collins JE, ... Holgate ST, et al. Defective epithelial barrier function in asthma. The Journal of Allergy and Clinical Immunology. 128: 549-56.e1-12. PMID 21752437 DOI: 10.1016/j.jaci.2011.05.038  0.466
2011 Holmes AM, Solari R, Holgate ST. Animal models of asthma: value, limitations and opportunities for alternative approaches. Drug Discovery Today. 16: 659-70. PMID 21723955 DOI: 10.1016/j.drudis.2011.05.014  0.416
2011 Schauberger EM, Ewart SL, Arshad SH, Huebner M, Karmaus W, Holloway JW, Friderici KH, Ziegler JT, Zhang H, Rose-Zerilli MJ, Barton SJ, Holgate ST, Kilpatrick JR, Harley JB, Lajoie-Kadoch S, et al. Identification of ATPAF1 as a novel candidate gene for asthma in children. The Journal of Allergy and Clinical Immunology. 128: 753-760.e11. PMID 21696813 DOI: 10.1016/J.Jaci.2011.04.058  0.551
2011 Holgate ST. The sentinel role of the airway epithelium in asthma pathogenesis. Immunological Reviews. 242: 205-19. PMID 21682747 DOI: 10.1111/j.1600-065X.2011.01030.x  0.546
2011 Dunford PJ, Holgate ST. The role of histamine in asthma. Advances in Experimental Medicine and Biology. 709: 53-66. PMID 21618887 DOI: 10.1007/978-1-4419-8056-4_6  0.405
2011 Holgate ST. Asthma: a simple concept but in reality a complex disease. European Journal of Clinical Investigation. 41: 1339-52. PMID 21615731 DOI: 10.1111/j.1365-2362.2011.02534.x  0.46
2011 Grainge CL, Lau LC, Ward JA, Dulay V, Lahiff G, Wilson S, Holgate S, Davies DE, Howarth PH. Effect of bronchoconstriction on airway remodeling in asthma. The New England Journal of Medicine. 364: 2006-15. PMID 21612469 DOI: 10.1056/NEJMoa1014350  0.47
2011 Maeda Y, Chen G, Xu Y, Haitchi HM, Du L, Keiser AR, Howarth PH, Davies DE, Holgate ST, Whitsett JA. Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation. American Journal of Respiratory and Critical Care Medicine. 184: 421-9. PMID 21562130 DOI: 10.1164/rccm.201101-0106OC  0.382
2011 Cakebread JA, Xu Y, Grainge C, Kehagia V, Howarth PH, Holgate ST, Davies DE. Exogenous IFN-β has antiviral and anti-inflammatory properties in primary bronchial epithelial cells from asthmatic subjects exposed to rhinovirus. The Journal of Allergy and Clinical Immunology. 127: 1148-54.e9. PMID 21329968 DOI: 10.1016/j.jaci.2011.01.023  0.348
2011 Holgate ST. The acetaminophen enigma in asthma. American Journal of Respiratory and Critical Care Medicine. 183: 147-8. PMID 21242591 DOI: 10.1164/rccm.201007-1135ED  0.519
2010 Bousquet J, Mantzouranis E, Cruz AA, Aït-Khaled N, Baena-Cagnani CE, Bleecker ER, Brightling CE, Burney P, Bush A, Busse WW, Casale TB, Chan-Yeung M, Chen R, Chowdhury B, Chung KF, ... ... Holgate ST, et al. Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. The Journal of Allergy and Clinical Immunology. 126: 926-38. PMID 20926125 DOI: 10.1016/J.Jaci.2010.07.019  0.529
2010 Holgate ST. ADAM metallopeptidase domain 33 (ADAM33): identification and role in airways disease. Drug News & Perspectives. 23: 381-7. PMID 20697605 DOI: 10.1358/dnp.2010.23.6.1437242  0.496
2010 Holloway JW, Arshad SH, Holgate ST. Using genetics to predict the natural history of asthma? The Journal of Allergy and Clinical Immunology. 126: 200-9; quiz 210-1. PMID 20688205 DOI: 10.1016/j.jaci.2010.06.006  0.572
2010 Holgate ST. A brief history of asthma and its mechanisms to modern concepts of disease pathogenesis. Allergy, Asthma & Immunology Research. 2: 165-71. PMID 20592914 DOI: 10.4168/aair.2010.2.3.165  0.54
2010 Holgate ST. A look at the pathogenesis of asthma: the need for a change in direction. Discovery Medicine. 9: 439-47. PMID 20515612  0.464
2010 Elwyn G, Crowe S, Fenton M, Firkins L, Versnel J, Walker S, Cook I, Holgate S, Higgins B, Gelder C. Identifying and prioritizing uncertainties: patient and clinician engagement in the identification of research questions. Journal of Evaluation in Clinical Practice. 16: 627-31. PMID 20482747 DOI: 10.1111/j.1365-2753.2009.01262.x  0.421
2010 Holloway JW, Yang IA, Holgate ST. Genetics of allergic disease. The Journal of Allergy and Clinical Immunology. 125: S81-94. PMID 20176270 DOI: 10.1016/j.jaci.2009.10.071  0.393
2010 Holgate ST, Arshad HS, Roberts GC, Howarth PH, Thurner P, Davies DE. A new look at the pathogenesis of asthma. Clinical Science (London, England : 1979). 118: 439-50. PMID 20025610 DOI: 10.1042/CS20090474  0.472
2010 Holgate ST. Has the time come to rethink the pathogenesis of asthma? Current Opinion in Allergy and Clinical Immunology. 10: 48-53. PMID 19915457 DOI: 10.1097/ACI.0b013e3283347be5  0.523
2009 Holgate ST, Roberts G, Arshad HS, Howarth PH, Davies DE. The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis. Proceedings of the American Thoracic Society. 6: 655-9. PMID 20008870 DOI: 10.1513/pats.200907-072DP  0.543
2009 Holgate ST, Davies DE. Rethinking the pathogenesis of asthma. Immunity. 31: 362-7. PMID 19766079 DOI: 10.1016/j.immuni.2009.08.013  0.529
2009 Koppelman GH, Meyers DA, Howard TD, Zheng SL, Hawkins GA, Ampleford EJ, Xu J, Koning H, Bruinenberg M, Nolte IM, van Diemen CC, Boezen HM, Timens W, Whittaker PA, Stine OC, ... ... Holgate ST, et al. Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness. American Journal of Respiratory and Critical Care Medicine. 180: 929-35. PMID 19729670 DOI: 10.1164/rccm.200810-1621OC  0.528
2009 Haitchi HM, Bassett DJ, Bucchieri F, Gao X, Powell RM, Hanley NA, Wilson DI, Holgate ST, Davies DE. Induction of a disintegrin and metalloprotease 33 during embryonic lung development and the influence of IL-13 or maternal allergy. The Journal of Allergy and Clinical Immunology. 124: 590-7, 597.e1-11. PMID 19665773 DOI: 10.1016/j.jaci.2009.06.026  0.411
2009 Jie Z, Jin M, Cai Y, Bai C, Shen Y, Yuan Z, Hu Y, Holgate S. The effects of Th2 cytokines on the expression of ADAM33 in allergen-induced chronic airway inflammation. Respiratory Physiology & Neurobiology. 168: 289-94. PMID 19635592 DOI: 10.1016/j.resp.2009.07.019  0.349
2009 Barton SJ, Koppelman GH, Vonk JM, Browning CA, Nolte IM, Stewart CE, Bainbridge S, Mutch S, Rose-Zerilli MJ, Postma DS, Maniatis N, Henry AP, Hall IP, Holgate ST, Tighe P, et al. PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline Journal of Allergy and Clinical Immunology. 123: 1391-1400.e17. PMID 19443020 DOI: 10.1016/j.jaci.2009.03.014  0.454
2009 Holgate S, Buhl R, Bousquet J, Smith N, Panahloo Z, Jimenez P. The use of omalizumab in the treatment of severe allergic asthma: A clinical experience update. Respiratory Medicine. 103: 1098-113. PMID 19362459 DOI: 10.1016/j.rmed.2009.03.008  0.454
2009 Haughney J, Palkonen S, Price D, Thomas M, Holgate S. Driving asthma care in Europe: the Brussels Declaration. Primary Care Respiratory Journal : Journal of the General Practice Airways Group. 18: 55-6. PMID 19322504 DOI: 10.4104/pcrj.2009.00015  0.402
2009 Szczepankiewicz A, Rose-Zerilli MJ, Barton SJ, Holgate ST, Holloway JW. Association analysis of brain-derived neurotrophic factor gene polymorphisms in asthmatic families International Archives of Allergy and Immunology. 149: 343-349. PMID 19295238 DOI: 10.1159/000205580  0.478
2009 Bedke N, Haitchi HM, Xatzipsalti M, Holgate ST, Davies DE. Contribution of bronchial fibroblasts to the antiviral response in asthma. Journal of Immunology (Baltimore, Md. : 1950). 182: 3660-7. PMID 19265144 DOI: 10.4049/jimmunol.0802471  0.485
2009 Wenzel SE, Barnes PJ, Bleecker ER, Bousquet J, Busse W, Dahlén SE, Holgate ST, Meyers DA, Rabe KF, Antczak A, Baker J, Horvath I, Mark Z, Bernstein D, Kerwin E, et al. A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. American Journal of Respiratory and Critical Care Medicine. 179: 549-58. PMID 19136369 DOI: 10.1164/rccm.200809-1512OC  0.323
2009 Holgate ST. Novel targets of therapy in asthma. Current Opinion in Pulmonary Medicine. 15: 63-71. PMID 19077708 DOI: 10.1097/MCP.0b013e32831da867  0.42
2009 Holgate ST. Are long-acting beta2-agonists safe in the treatment of asthma? Polskie Archiwum Medycyny Wewnetrznej. 118: 460-1. PMID 18846978  0.353
2008 Pemberton AD, Rose-Zerilli MJ, Holloway JW, Gray RD, Holgate ST. A single-nucleotide polymorphism in intelectin 1 is associated with increased asthma risk. The Journal of Allergy and Clinical Immunology. 122: 1033-4. PMID 19000584 DOI: 10.1016/J.Jaci.2008.08.037  0.426
2008 Holgate ST. Pathogenesis of asthma. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. 38: 872-97. PMID 18498538 DOI: 10.1111/j.1365-2222.2008.02971.x  0.395
2008 Yang Y, Haitchi HM, Cakebread J, Sammut D, Harvey A, Powell RM, Holloway JW, Howarth P, Holgate ST, Davies DE. Epigenetic mechanisms silence a disintegrin and metalloprotease 33 expression in bronchial epithelial cells. The Journal of Allergy and Clinical Immunology. 121: 1393-9, 1399.e1-14. PMID 18423563 DOI: 10.1016/j.jaci.2008.02.031  0.486
2008 Puxeddu I, Pang YY, Harvey A, Haitchi HM, Nicholas B, Yoshisue H, Ribatti D, Clough G, Powell RM, Murphy G, Hanley NA, Wilson DI, Howarth PH, Holgate ST, Davies DE. The soluble form of a disintegrin and metalloprotease 33 promotes angiogenesis: implications for airway remodeling in asthma. The Journal of Allergy and Clinical Immunology. 121: 1400-6, 1406.e1-4. PMID 18410963 DOI: 10.1016/J.Jaci.2008.03.003  0.36
2008 Babu KS, Gadzik F, Holgate ST. Absence of respiratory effects with ivabradine in patients with asthma. British Journal of Clinical Pharmacology. 66: 96-101. PMID 18341671 DOI: 10.1111/j.1365-2125.2008.03160.x  0.335
2008 Holloway JW, Yang IA, Holgate ST. Interpatient variability in rates of asthma progression: can genetics provide an answer? The Journal of Allergy and Clinical Immunology. 121: 573-9. PMID 18328888 DOI: 10.1016/j.jaci.2008.01.007  0.572
2008 Holgate ST. The airway epithelium is central to the pathogenesis of asthma. Allergology International : Official Journal of the Japanese Society of Allergology. 57: 1-10. PMID 18209502 DOI: 10.2332/allergolint.R-07-154  0.493
2008 Holgate ST. Epithelium dysfunction in asthma. The Journal of Allergy and Clinical Immunology. 120: 1233-44; quiz 1245-6. PMID 18073119 DOI: 10.1016/j.jaci.2007.10.025  0.388
2007 Wark PA, Bucchieri F, Johnston SL, Gibson PG, Hamilton L, Mimica J, Zummo G, Holgate ST, Attia J, Thakkinstian A, Davies DE. IFN-gamma-induced protein 10 is a novel biomarker of rhinovirus-induced asthma exacerbations. The Journal of Allergy and Clinical Immunology. 120: 586-93. PMID 17628646 DOI: 10.1016/j.jaci.2007.04.046  0.375
2007 Holgate ST. The epithelium takes centre stage in asthma and atopic dermatitis. Trends in Immunology. 28: 248-51. PMID 17466594 DOI: 10.1016/j.it.2007.04.007  0.356
2007 Watson L, Turk F, James P, Holgate ST. Factors associated with mortality after an asthma admission: a national United Kingdom database analysis. Respiratory Medicine. 101: 1659-64. PMID 17462875 DOI: 10.1016/j.rmed.2007.03.006  0.434
2007 Chanez P, Wenzel SE, Anderson GP, Anto JM, Bel EH, Boulet LP, Brightling CE, Busse WW, Castro M, Dahlen B, Dahlen SE, Fabbri LM, Holgate ST, Humbert M, Gaga M, et al. Severe asthma in adults: what are the important questions? The Journal of Allergy and Clinical Immunology. 119: 1337-48. PMID 17416409 DOI: 10.1016/J.Jaci.2006.11.702  0.474
2006 Price D, Holgate ST. Improving outcomes for asthma patients with allergic rhinitis: conclusions from the MetaForum conferences. Bmc Pulmonary Medicine. S7. PMID 17140425 DOI: 10.1186/1471-2466-6-S1-S7  0.433
2006 Holgate ST, Price D, Valovirta E. Asthma out of control? A structured review of recent patient surveys. Bmc Pulmonary Medicine. S2. PMID 17140420 DOI: 10.1186/1471-2466-6-S1-S2  0.465
2006 Wenzel S, Holgate ST. The mouse trap: It still yields few answers in asthma American Journal of Respiratory and Critical Care Medicine. 174: 1173-1176. PMID 17110654 DOI: 10.1164/rccm.2609002  0.475
2006 Holgate ST. Rhinoviruses in the pathogenesis of asthma: the bronchial epithelium as a major disease target. The Journal of Allergy and Clinical Immunology. 118: 587-90. PMID 16950275 DOI: 10.1016/j.jaci.2006.06.023  0.486
2006 Holgate ST, Polosa R. The mechanisms, diagnosis, and management of severe asthma in adults. Lancet (London, England). 368: 780-93. PMID 16935689 DOI: 10.1016/S0140-6736(06)69288-X  0.47
2006 Contoli M, Message SD, Laza-Stanca V, Edwards MR, Wark PA, Bartlett NW, Kebadze T, Mallia P, Stanciu LA, Parker HL, Slater L, Lewis-Antes A, Kon OM, Holgate ST, Davies DE, et al. Role of deficient type III interferon-lambda production in asthma exacerbations. Nature Medicine. 12: 1023-6. PMID 16906156 DOI: 10.1038/nm1462  0.408
2006 Holgate ST. Susceptibility genes in severe asthma. Current Allergy and Asthma Reports. 6: 345-8. PMID 16822389 DOI: 10.1007/s11882-006-0071-y  0.512
2006 Holgate ST, Yang Y, Haitchi HM, Powell RM, Holloway JW, Yoshisue H, Pang YY, Cakebread J, Davies DE. The genetics of asthma: ADAM33 as an example of a susceptibility gene. Proceedings of the American Thoracic Society. 3: 440-3. PMID 16799089 DOI: 10.1513/pats.200603-026AW  0.532
2006 Polosa R, Holgate ST. Adenosine receptors as promising therapeutic targets for drug development in chronic airway inflammation. Current Drug Targets. 7: 699-706. PMID 16787172 DOI: 10.2174/138945006777435236  0.411
2006 Bradding P, Walls AF, Holgate ST. The role of the mast cell in the pathophysiology of asthma. The Journal of Allergy and Clinical Immunology. 117: 1277-84. PMID 16750987 DOI: 10.1016/j.jaci.2006.02.039  0.476
2006 Caruso M, Holgate ST, Polosa R. Adenosine signalling in airways. Current Opinion in Pharmacology. 6: 251-6. PMID 16584919 DOI: 10.1016/j.coph.2006.02.002  0.487
2006 Holgate ST, Holloway J, Wilson S, Howarth PH, Haitchi HM, Babu S, Davies DE. Understanding the pathophysiology of severe asthma to generate new therapeutic opportunities. The Journal of Allergy and Clinical Immunology. 117: 496-506; quiz 507. PMID 16522446 DOI: 10.1016/j.jaci.2006.01.039  0.509
2006 Yang IA, Fong KM, Holgate ST, Holloway JW. The role of Toll-like receptors and related receptors of the innate immune system in asthma. Current Opinion in Allergy and Clinical Immunology. 6: 23-8. PMID 16505608 DOI: 10.1097/01.all.0000200503.77295.bb  0.313
2006 Burkart KM, Barton SJ, Holloway JW, Yang IA, Cakebread JA, Cruikshank W, Little F, Jin X, Farrer LA, Clough JB, Keith TP, Holgate S, Center DM, O'Connor GT. Association of asthma with a functional promoter polymorphism in the IL16 gene. The Journal of Allergy and Clinical Immunology. 117: 86-91. PMID 16387589 DOI: 10.1016/j.jaci.2005.10.011  0.315
2006 Holgate ST. Exacerbations: the asthma paradox. American Journal of Respiratory and Critical Care Medicine. 172: 941-3. PMID 16216836 DOI: 10.1164/rccm.2507007  0.522
2006 Holgate ST, Davies DE, Powell RM, Holloway JW. ADAM33: a newly identified protease involved in airway remodelling. Pulmonary Pharmacology & Therapeutics. 19: 3-11. PMID 15953744 DOI: 10.1016/j.pupt.2005.02.008  0.513
2005 Holgate ST, Davies DE, Powell RM, Holloway JW. ADAM33: a newly identified gene in the pathogenesis of asthma. Immunology and Allergy Clinics of North America. 25: 655-68. PMID 16257631 DOI: 10.1016/j.iac.2005.07.003  0.497
2005 Norris V, Choong L, Tran D, Corden Z, Boyce M, Arshad H, Holgate S, O'Connor B, Millet S, Miller B, Rohatagi S, Kirkesseli S. Effect of IVL745, a VLA-4 antagonist, on allergen-induced bronchoconstriction in patients with asthma. The Journal of Allergy and Clinical Immunology. 116: 761-7. PMID 16210048 DOI: 10.1016/J.Jaci.2005.04.045  0.484
2005 Holgate ST. The Quintiles Prize Lecture 2004. The identification of the adenosine A2B receptor as a novel therapeutic target in asthma. British Journal of Pharmacology. 145: 1009-15. PMID 15980878 DOI: 10.1038/sj.bjp.0706272  0.301
2005 Bruton A, Holgate ST. Hypocapnia and asthma: a mechanism for breathing retraining? Chest. 127: 1808-11. PMID 15888863 DOI: 10.1378/chest.127.5.1808  0.409
2005 Holgate S, Casale T, Wenzel S, Bousquet J, Deniz Y, Reisner C. The anti-inflammatory effects of omalizumab confirm the central role of IgE in allergic inflammation. The Journal of Allergy and Clinical Immunology. 115: 459-65. PMID 15753888 DOI: 10.1016/j.jaci.2004.11.053  0.426
2005 Haitchi HM, Powell RM, Shaw TJ, Howarth PH, Wilson SJ, Wilson DI, Holgate ST, Davies DE. ADAM33 expression in asthmatic airways and human embryonic lungs. American Journal of Respiratory and Critical Care Medicine. 171: 958-65. PMID 15709049 DOI: 10.1164/rccm.200409-1251OC  0.448
2005 Holgate ST. Cytokine and anti-cytokine therapy for the treatment of asthma and allergic disease. Cytokine. 28: 152-7. PMID 15588688 DOI: 10.1016/j.cyto.2004.07.010  0.489
2004 Holgate ST, Holloway J, Wilson S, Bucchieri F, Puddicombe S, Davies DE. Epithelial-mesenchymal communication in the pathogenesis of chronic asthma. Proceedings of the American Thoracic Society. 1: 93-8. PMID 16113419 DOI: 10.1513/pats.2306034  0.454
2004 Babu KS, Davies DE, Holgate ST. Role of tumor necrosis factor alpha in asthma. Immunology and Allergy Clinics of North America. 24: 583-97, v-vi. PMID 15474860 DOI: 10.1016/j.iac.2004.06.010  0.41
2004 Asher I, Baena-Cagnani C, Boner A, Canonica GW, Chuchalin A, Custovic A, Dagli E, Haahtela T, Haus M, Lemmo-Hoten M, Holgate S, Holloway J, Holt P, Host A, Iikura Y, et al. World Allergy Organization guidelines for prevention of allergy and allergic asthma. International Archives of Allergy and Immunology. 135: 83-92. PMID 15452918 DOI: 10.1159/000080524  0.457
2004 Holloway JW, Davies DE, Powell R, Haitchi HM, Keith TP, Holgate ST. The discovery and role of ADAM33, a new candidate gene for asthma. Expert Reviews in Molecular Medicine. 6: 1-12. PMID 15387895 DOI: 10.1017/S1462399404007963  0.508
2004 Holgate ST, Davies DE, Rorke S, Cakebread J, Murphy G, Powell RM, Holloway JW. ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma Clinical Reviews in Allergy and Immunology. 27: 23-34. PMID 15347848  0.434
2004 Djukanovi? R, Wilson SJ, Kraft M, Jarjour NN, Steel M, Chung KF, Bao W, Fowler-Taylor A, Matthews J, Busse WW, Holgate ST, Fahy JV. Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma. American Journal of Respiratory and Critical Care Medicine. 170: 583-93. PMID 15172898 DOI: 10.1164/rccm.200312-1651OC  0.486
2004 Bousquet J, Wenzel S, Holgate S, Lumry W, Freeman P, Fox H. Predicting response to omalizumab, an anti-IgE antibody, in patients with allergic asthma. Chest. 125: 1378-86. PMID 15078749 DOI: 10.1378/chest.125.4.1378  0.38
2004 Cakebread JA, Haitchi HM, Holloway JW, Powell RM, Keith T, Davies DE, Holgate ST. The role of ADAM33 in the pathogenesis of asthma. Springer Seminars in Immunopathology. 25: 361-75. PMID 14999429 DOI: 10.1007/s00281-003-0153-z  0.526
2004 Holgate ST. The epidemic of asthma and allergy. Journal of the Royal Society of Medicine. 97: 103-10. PMID 14996954 DOI: 10.1177/014107680409700302  0.518
2004 Powell RM, Wicks J, Holloway JW, Holgate ST, Davies DE. The splicing and fate of ADAM33 transcripts in primary human airways fibroblasts American Journal of Respiratory Cell and Molecular Biology. 31: 13-21. PMID 14742294 DOI: 10.1165/rcmb.2003-0330OC  0.305
2004 Rorke S, Holgate ST. Targeting adenosine receptors: novel therapeutic targets in asthma and chronic obstructive pulmonary disease. American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions. 1: 99-105. PMID 14720064 DOI: 10.1007/BF03256599  0.403
2003 Bjermer L, Bisgaard H, Bousquet J, Fabbri LM, Greening AP, Haahtela T, Holgate ST, Picado C, Menten J, Dass SB, Leff JA, Polos PG. Montelukast and fluticasone compared with salmeterol and fluticasone in protecting against asthma exacerbation in adults: one year, double blind, randomised, comparative trial. Bmj (Clinical Research Ed.). 327: 891. PMID 14563743 DOI: 10.1136/bmj.327.7420.891  0.375
2003 Powell RM, Hamilton LM, Holgate ST, Davies DE, Holloway JW. ADAM33: a novel therapeutic target for asthma. Expert Opinion On Therapeutic Targets. 7: 485-94. PMID 12885268 DOI: 10.1517/14728222.7.4.485  0.529
2003 Wallin A, Sue-Chu M, Bjermer L, Ward J, Sandström T, Lindberg A, Lundbäck B, Djukanović R, Holgate S, Wilson S. Effect of inhaled fluticasone with and without salmeterol on airway inflammation in asthma. The Journal of Allergy and Clinical Immunology. 112: 72-8. PMID 12847482 DOI: 10.1067/MAI.2003.1518  0.438
2003 Chauhan AJ, Inskip HM, Linaker CH, Smith S, Schreiber J, Johnston SL, Holgate ST. Personal exposure to nitrogen dioxide (NO2) and the severity of virus-induced asthma in children. Lancet. 361: 1939-44. PMID 12801737  0.374
2003 Watson MW, Beasley R, Holgate ST, Bardin PG. Rhinovirus is not detectable in peripheral lung tissue after asthma death. Respirology (Carlton, Vic.). 8: 234-8. PMID 12753541 DOI: 10.1046/j.1440-1843.2003.00462.x  0.488
2003 Davies DE, Wicks J, Powell RM, Puddicombe SM, Holgate ST. Airway remodeling in asthma: New insights Journal of Allergy and Clinical Immunology. 111: 215-226. PMID 12589337 DOI: 10.1067/mai.2003.128  0.523
2003 Holgate ST, Peters-Golden M, Panettieri RA, Henderson WR. Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling. The Journal of Allergy and Clinical Immunology. 111: S18-34; discussion S. PMID 12532084 DOI: 10.1067/mai.2003.25  0.402
2003 Holgate ST, Peters-Golden M. Introduction: the anti-inflammatory role of cysteinyl leukotriene receptor antagonists in asthma. The Journal of Allergy and Clinical Immunology. 111: S1-4. PMID 12532082 DOI: 10.1067/mai.2003.107  0.362
2003 Prosperini G, Rajakulasingam K, Cacciola RR, Spicuzza L, Rorke S, Holgate ST, Di Maria GU, Polosa R. Changes in sputum counts and airway hyperresponsiveness after budesonide: monitoring anti-inflammatory response on the basis of surrogate markers of airway inflammation. The Journal of Allergy and Clinical Immunology. 110: 855-61. PMID 12464950 DOI: 10.1067/mai.2002.130050  0.432
2003 Holgate ST. Airway inflammation and remodeling in asthma: current concepts. Molecular Biotechnology. 22: 179-89. PMID 12405265 DOI: 10.1385/MB:22:2:179  0.491
2002 Krishna MT, Hatzivlassiou P, Salvi SS, Holgate ST. Current and future asthma therapies. The Practitioner. 246: 820-5. PMID 12489358  0.423
2002 Yuyama N, Davies DE, Akaiwa M, Matsui K, Hamasaki Y, Suminami Y, Yoshida NL, Maeda M, Pandit A, Lordan JL, Kamogawa Y, Arima K, Nagumo F, Sugimachi M, Berger A, ... ... Holgate ST, et al. Analysis of novel disease-related genes in bronchial asthma Cytokine. 19: 287-296. PMID 12421571 DOI: 10.1006/Cyto.2002.1972  0.453
2002 Babu KS, Holgate ST. The role of anti-IgE therapies in the treatment of asthma. Hospital Medicine (London, England : 1998). 63: 483-6. PMID 12212420  0.431
2002 Bucchieri F, Puddicombe SM, Lordan JL, Richter A, Buchanan D, Wilson SJ, Ward J, Zummo G, Howarth PH, Djukanović R, Holgate ST, Davies DE. Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis. American Journal of Respiratory Cell and Molecular Biology. 27: 179-85. PMID 12151309 DOI: 10.1165/ajrcmb.27.2.4699  0.37
2002 Ritz SA, Stämpfli MR, Davies DE, Holgate ST, Jordana M. On the generation of allergic airway diseases: From GM-CSF to Kyoto Trends in Immunology. 23: 396-402. PMID 12133802 DOI: 10.1016/S1471-4906(02)02278-0  0.335
2002 Lordan JL, Holgate ST. H1-antihistamines in asthma. Clinical Allergy and Immunology. 17: 221-48. PMID 12113218  0.497
2002 Van Eerdewegh P, Little RD, Dupuis J, Del Mastro RG, Falls K, Simon J, Torrey D, Pandit S, McKenny J, Braunschweiger K, Walsh A, Liu Z, Hayward B, Folz C, Manning SP, ... ... Holgate ST, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature. 418: 426-30. PMID 12110844 DOI: 10.1038/Nature00878  0.551
2002 Brightling CE, Bradding P, Symon FA, Holgate ST, Wardlaw AJ, Pavord ID. Mast-cell infiltration of airway smooth muscle in asthma. The New England Journal of Medicine. 346: 1699-705. PMID 12037149 DOI: 10.1056/NEJMoa012705  0.46
2002 Babu KS, Holgate ST. Newer therapies for asthma: a focus on anti-IgE. The Indian Journal of Chest Diseases & Allied Sciences. 44: 107-15. PMID 12026249  0.504
2002 Holgate ST. Asthma: more than an inflammatory disease. Current Opinion in Allergy and Clinical Immunology. 2: 27-9. PMID 11964747 DOI: 10.1097/00130832-200202000-00005  0.481
2002 Holgate ST. Adenosine: a key effector molecule of asthma or just another mediator? American Journal of Physiology. Lung Cellular and Molecular Physiology. 282: L167-8. PMID 11792619 DOI: 10.1152/ajplung.00386.2001  0.444
2002 Rhodes HL, Thomas P, Sporik R, Holgate ST, Cogswell JJ. A birth cohort study of subjects at risk of atopy: twenty-two-year follow-up of wheeze and atopic status. American Journal of Respiratory and Critical Care Medicine. 165: 176-80. PMID 11790650 DOI: 10.1164/ajrccm.165.2.2104032  0.338
2002 Dahlén SE, Malmström K, Nizankowska E, Dahlén B, Kuna P, Kowalski M, Lumry WR, Picado C, Stevenson DD, Bousquet J, Pauwels R, Holgate ST, Shahane A, Zhang J, Reiss TF, et al. Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebo-controlled trial. American Journal of Respiratory and Critical Care Medicine. 165: 9-14. PMID 11779723 DOI: 10.1164/ajrccm.165.1.2010080  0.473
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