W. V. Graham, Ph.D.

Affiliations: 
2010 Pathology University of Chicago, Chicago, IL 
Area:
Molecular Biology, Cell Biology, General Biology
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Jerrold R. Turner grad student 2010 Chicago
 (Molecular mechanisms of epithelial MLCK isoform regulation: Characterization and pharmacological exploitation.)
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Publications

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Graham WV, He W, Marchiando AM, et al. (2019) Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis. Nature Medicine
Marchiando AM, Shen L, Graham WV, et al. (2010) Caveolin-1-dependent occludin endocytosis is required for TNF-induced tight junction regulation in vivo. The Journal of Cell Biology. 189: 111-26
Wang F, Schwarz BT, Graham WV, et al. (2006) IFN-gamma-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction. Gastroenterology. 131: 1153-63
Graham WV, Wang F, Clayburgh DR, et al. (2006) Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter. The Journal of Biological Chemistry. 281: 26205-15
Hu Z, Wang Y, Graham WV, et al. (2006) MAPKAPK-2 is a critical signaling intermediate in NHE3 activation following Na+-glucose cotransport. The Journal of Biological Chemistry. 281: 24247-53
Owens SE, Graham WV, Siccardi D, et al. (2005) A strategy to identify stable membrane-permeant peptide inhibitors of myosin light chain kinase. Pharmaceutical Research. 22: 703-9
Russo JM, Florian P, Shen L, et al. (2005) Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure. Gastroenterology. 128: 987-1001
Wang F, Graham WV, Wang Y, et al. (2005) Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. The American Journal of Pathology. 166: 409-19
Graham WV, Tcheng DK, Shirk AL, et al. (2004) Phylomat: an automated protein motif analysis tool for phylogenomics. Journal of Proteome Research. 3: 1289-91
Conour JE, Graham WV, Gaskins HR. (2004) A combined in vitro/bioinformatic investigation of redox regulatory mechanisms governing cell cycle progression. Physiological Genomics. 18: 196-205
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