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Holly A. Leddy, Ph.D. - Publications

Affiliations: 
2007 Duke University, Durham, NC 
Area:
Biomedical, General, Biomechanics
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31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Willard VP, Leddy HA, Palmer D, Wu CL, Liedtke W, Guilak F. Transient receptor potential vanilloid 4 as a regulator of induced pluripotent stem cell chondrogenesis. Stem Cells (Dayton, Ohio). PMID 34427363 DOI: 10.1002/stem.3440  0.776
2021 Lee W, Nims RJ, Savadipour A, Zhang Q, Leddy HA, Liu F, McNulty AL, Chen Y, Guilak F, Liedtke WB. Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33758095 DOI: 10.1073/pnas.2001611118  0.781
2019 Gilchrist CL, Leddy HA, Kaye L, Case ND, Rothenberg KE, Little D, Liedtke W, Hoffman BD, Guilak F. TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension. Proceedings of the National Academy of Sciences of the United States of America. PMID 30674675 DOI: 10.1073/Pnas.1811095116  0.774
2016 Lee W, Leddy H, McNulty A, Guilak F, Liedtke W. Inflammatory Cytokine Il-1α Up-Regulates Piezo1 and Hyper-Sensitizes Chondrocytes to Compression Biophysical Journal. 110: 349a. DOI: 10.1016/J.Bpj.2015.11.1878  0.783
2015 Zelenski NA, Leddy HA, Sanchez-Adams J, Zhang J, Bonaldo P, Liedtke W, Guilak F. Type VI Collagen Regulates Pericellular Matrix Properties, Chondrocyte Swelling, and Mechanotransduction in Mouse Articular Cartilage. Arthritis & Rheumatology (Hoboken, N.J.). 67: 1286-94. PMID 25604429 DOI: 10.1002/Art.39034  0.799
2015 McNulty AL, Leddy HA, Liedtke W, Guilak F. TRPV4 as a therapeutic target for joint diseases. Naunyn-Schmiedeberg's Archives of Pharmacology. 388: 437-50. PMID 25519495 DOI: 10.1007/S00210-014-1078-X  0.637
2014 Leddy HA, McNulty AL, Guilak F, Liedtke W. Unraveling the mechanism by which TRPV4 mutations cause skeletal dysplasias. Rare Diseases (Austin, Tex.). 2: e962971. PMID 26942100 DOI: 10.4161/2167549X.2014.962971  0.479
2014 Lee W, Leddy HA, Chen Y, Lee SH, Zelenski NA, McNulty AL, Wu J, Beicker KN, Coles J, Zauscher S, Grandl J, Sachs F, Guilak F, Liedtke WB. Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. Proceedings of the National Academy of Sciences of the United States of America. 111: E5114-22. PMID 25385580 DOI: 10.1073/Pnas.1414298111  0.797
2014 Sanchez-Adams J, Leddy HA, McNulty AL, O'Conor CJ, Guilak F. The mechanobiology of articular cartilage: bearing the burden of osteoarthritis. Current Rheumatology Reports. 16: 451. PMID 25182679 DOI: 10.1007/S11926-014-0451-6  0.768
2014 Leddy HA, McNulty AL, Lee SH, Rothfusz NE, Gloss B, Kirby ML, Hutson MR, Cohn DH, Guilak F, Liedtke W. Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 28: 2525-37. PMID 24577120 DOI: 10.1096/Fj.13-245936  0.49
2014 O'Conor CJ, Leddy HA, Benefield HC, Liedtke WB, Guilak F. TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading. Proceedings of the National Academy of Sciences of the United States of America. 111: 1316-21. PMID 24474754 DOI: 10.1073/Pnas.1319569111  0.806
2014 Lee W, Leddy H, Guilak F, Liedtke W. Characterization of Mechanotransensitivity of Articular Chondrocytes Biophysical Journal. 106: 389a-390a. DOI: 10.1016/J.Bpj.2013.11.2202  0.791
2013 Widmyer MR, Utturkar GM, Leddy HA, Coleman JL, Spritzer CE, Moorman CT, DeFrate LE, Guilak F. High body mass index is associated with increased diurnal strains in the articular cartilage of the knee. Arthritis and Rheumatism. 65: 2615-22. PMID 23818303 DOI: 10.1002/Art.38062  0.532
2013 McNulty AL, Rothfusz NE, Leddy HA, Guilak F. Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 31: 1039-45. PMID 23483596 DOI: 10.1002/Jor.22334  0.504
2013 Coleman JL, Widmyer MR, Leddy HA, Utturkar GM, Spritzer CE, Moorman CT, Guilak F, DeFrate LE. Diurnal variations in articular cartilage thickness and strain in the human knee. Journal of Biomechanics. 46: 541-7. PMID 23102493 DOI: 10.1016/J.Jbiomech.2012.09.013  0.565
2012 Davis BH, Morimoto Y, Sample C, Olbrich K, Leddy HA, Guilak F, Taylor DA. Effects of myocardial infarction on the distribution and transport of nutrients and oxygen in porcine myocardium. Journal of Biomechanical Engineering. 134: 101005. PMID 23083196 DOI: 10.1115/1.4007455  0.475
2012 Christensen SE, Coles JM, Zelenski NA, Furman BD, Leddy HA, Zauscher S, Bonaldo P, Guilak F. Altered trabecular bone structure and delayed cartilage degeneration in the knees of collagen VI null mice. Plos One. 7: e33397. PMID 22448243 DOI: 10.1371/Journal.Pone.0033397  0.681
2011 Finan JD, Leddy HA, Guilak F. Osmotic stress alters chromatin condensation and nucleocytoplasmic transport. Biochemical and Biophysical Research Communications. 408: 230-5. PMID 21463604 DOI: 10.1016/J.Bbrc.2011.03.131  0.711
2010 Guilak F, Leddy HA, Liedtke W. Transient receptor potential vanilloid 4: The sixth sense of the musculoskeletal system? Annals of the New York Academy of Sciences. 1192: 404-9. PMID 20392266 DOI: 10.1111/J.1749-6632.2010.05389.X  0.591
2009 Phan MN, Leddy HA, Votta BJ, Kumar S, Levy DS, Lipshutz DB, Lee SH, Liedtke W, Guilak F. Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes. Arthritis and Rheumatism. 60: 3028-37. PMID 19790068 DOI: 10.1002/Art.24799  0.584
2008 Leddy HA, Christensen SE, Guilak F. Microscale diffusion properties of the cartilage pericellular matrix measured using 3D scanning microphotolysis. Journal of Biomechanical Engineering. 130: 061002. PMID 19045531 DOI: 10.1115/1.2979876  0.69
2008 Leddy HA, Guilak F. Site-specific effects of compression on macromolecular diffusion in articular cartilage. Biophysical Journal. 95: 4890-5. PMID 18689460 DOI: 10.1529/Biophysj.108.137752  0.583
2008 Leddy H, Phan M, Votta B, Kumar S, Lee S, Liedtke W, Guilak F. A6 FUNCTIONAL CHARACTERIZATION OF TRPV4 AS AN OSMOTICALLY SENSITIVE ION CHANNEL IN ARTICULAR CHONDROCYTES Osteoarthritis and Cartilage. 16: S15-S16. DOI: 10.1016/S1063-4584(08)60052-7  0.482
2007 Choi JB, Youn I, Cao L, Leddy HA, Gilchrist CL, Setton LA, Guilak F. Zonal changes in the three-dimensional morphology of the chondron under compression: the relationship among cellular, pericellular, and extracellular deformation in articular cartilage. Journal of Biomechanics. 40: 2596-603. PMID 17397851 DOI: 10.1016/J.Jbiomech.2007.01.009  0.76
2006 Leddy HA, Haider MA, Guilak F. Diffusional anisotropy in collagenous tissues: fluorescence imaging of continuous point photobleaching. Biophysical Journal. 91: 311-6. PMID 16603503 DOI: 10.1529/Biophysj.105.075283  0.55
2006 Fetter NL, Leddy HA, Guilak F, Nunley JA. Composition and transport properties of human ankle and knee cartilage. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 24: 211-9. PMID 16435350 DOI: 10.1002/Jor.20029  0.586
2005 Tognana E, Chen F, Padera RF, Leddy HA, Christensen SE, Guilak F, Vunjak-Novakovic G, Freed LE. Adjacent tissues (cartilage, bone) affect the functional integration of engineered calf cartilage in vitro. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 13: 129-38. PMID 15694574 DOI: 10.1016/J.Joca.2004.10.015  0.697
2004 Guilak F, Awad HA, Fermor B, Leddy HA, Gimble JM. Adipose-derived adult stem cells for cartilage tissue engineering. Biorheology. 41: 389-99. PMID 15299271  0.671
2004 Leddy HA, Awad HA, Guilak F. Molecular diffusion in tissue-engineered cartilage constructs: effects of scaffold material, time, and culture conditions. Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 70: 397-406. PMID 15264325 DOI: 10.1002/Jbm.B.30053  0.688
2004 Awad HA, Wickham MQ, Leddy HA, Gimble JM, Guilak F. Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds. Biomaterials. 25: 3211-22. PMID 14980416 DOI: 10.1016/J.Biomaterials.2003.10.045  0.692
2003 Leddy HA, Guilak F. Site-specific molecular diffusion in articular cartilage measured using fluorescence recovery after photobleaching. Annals of Biomedical Engineering. 31: 753-60. PMID 12971608 DOI: 10.1114/1.1581879  0.494
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