| Year |
Citation |
Score |
| 2023 |
Hofmann C, Löwenthal Z, Aghajani M, Kaufman RJ, Katus HA, Frey N, Glembotski CC, Völkers M, Doroudgar S. mTORC1 inhibition impairs activation of the unfolded protein response and induces cell death during ER stress in cardiomyocytes. American Journal of Physiology. Heart and Circulatory Physiology. PMID 37294892 DOI: 10.1152/ajpheart.00682.2022 |
0.399 |
|
| 2022 |
Ajoolabady A, Lebeaupin C, Wu NN, Kaufman RJ, Ren J. ER stress and inflammation crosstalk in obesity. Medicinal Research Reviews. PMID 35975736 DOI: 10.1002/med.21921 |
0.326 |
|
| 2022 |
Ajoolabady A, Kaplowitz N, Lebeaupin C, Kroemer G, Kaufman RJ, Malhi H, Ren J. Endoplasmic Reticulum Stress in Liver Diseases. Hepatology (Baltimore, Md.). PMID 35524448 DOI: 10.1002/hep.32562 |
0.307 |
|
| 2021 |
Poothong J, Jang I, Kaufman RJ. Defects in Protein Folding and/or Quality Control Cause Protein Aggregation in the Endoplasmic Reticulum. Progress in Molecular and Subcellular Biology. 59: 115-143. PMID 34050864 DOI: 10.1007/978-3-030-67696-4_6 |
0.3 |
|
| 2021 |
Sidoli M, Reed CB, Scapin C, Paez P, Cavener DR, Kaufman RJ, D'Antonio M, Feltri ML, Wrabetz L. Calcineurin activity is increased in Charcot-Marie-Tooth 1B demyelinating neuropathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 33879538 DOI: 10.1523/JNEUROSCI.2384-20.2021 |
0.35 |
|
| 2020 |
Dasgupta D, Nakao Y, Mauer AS, Thompson JM, Sehrawat TS, Liao CY, Krishnan A, Lucien F, Guo Q, Liu M, Xue F, Fukushima M, Katsumi T, Bansal A, Pandey MK, ... ... Kaufman RJ, et al. IRE1A Stimulates Hepatocyte-derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis. Gastroenterology. PMID 32574624 DOI: 10.1053/J.Gastro.2020.06.031 |
0.306 |
|
| 2020 |
Hetz C, Zhang K, Kaufman RJ. Mechanisms, regulation and functions of the unfolded protein response. Nature Reviews. Molecular Cell Biology. PMID 32457508 DOI: 10.1038/S41580-020-0250-Z |
0.463 |
|
| 2020 |
Tran DT, Pottekat A, Mir SA, Loguercio S, Jang I, Campos AR, Scully KM, Lahmy R, Liu M, Arvan P, Balch WE, Kaufman RJ, Itkin-Ansari P. Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role For Peroxiredoxin 4 in Proinsulin Folding. Diabetes. PMID 32457219 DOI: 10.2337/Db20-0245 |
0.396 |
|
| 2020 |
Lebeaupin C, Yong J, Kaufman RJ. The Impact of the ER Unfolded Protein Response on Cancer Initiation and Progression: Therapeutic Implications. Advances in Experimental Medicine and Biology. 1243: 113-131. PMID 32297215 DOI: 10.1007/978-3-030-40204-4_8 |
0.476 |
|
| 2020 |
Sun J, Xiong Y, Li X, Haataja L, Chen W, Mir SA, Lv L, Madley R, Larkin D, Anjum A, Dhayalan B, Rege N, Wickramasinghe ND, Weiss MA, Itkin-Ansari P, ... Kaufman RJ, et al. Role of Proinsulin Self-Association in Mutant gene-induced Diabetes of Youth. Diabetes. PMID 32139596 DOI: 10.2337/Db19-1106 |
0.354 |
|
| 2020 |
Poothong J, Pottekat A, Siriin M, Campos AR, Paton AW, Paton JC, Lagunas-Acosta J, Chen Z, Swift M, Volkmann N, Hanein D, Yong J, Kaufman RJ. Factor VIII exhibits chaperone-dependent and glucose-regulated reversible amyloid formation in the endoplasmic reticulum. Blood. PMID 32128578 DOI: 10.1182/Blood.2019002867 |
0.441 |
|
| 2020 |
Stauffer WT, Blackwood EA, Azizi K, Kaufman RJ, Glembotski CC. The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts. International Journal of Molecular Sciences. 21. PMID 32085622 DOI: 10.3390/Ijms21041373 |
0.35 |
|
| 2020 |
Tran DT, Arvan P, Kaufman RJ, Itkin-Ansari P. 47-OR: A Reference Map of the Human Proinsulin Biosynthetic Interaction Network Diabetes. 69. DOI: 10.2337/Db20-47-Or |
0.337 |
|
| 2019 |
Kim JI, Kaufman RJ, Back SH, Moon JY. Development of a Reporter System Monitoring Regulated Intramembrane Proteolysis of the Transmembrane bZIP Transcription Factor ATF6α. Molecules and Cells. PMID 31707777 DOI: 10.14348/Molcells.2019.0104 |
0.501 |
|
| 2019 |
Pathak SS, Liu D, Li T, de Zavalia N, Zhu L, Li J, Karthikeyan R, Alain T, Liu AC, Storch KF, Kaufman RJ, Jin VX, Amir S, Sonenberg N, Cao R. The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4. Neuron. PMID 31522764 DOI: 10.1016/J.Neuron.2019.08.007 |
0.353 |
|
| 2019 |
Yong J, Bischof H, Burgstaller S, Siirin M, Murphy A, Malli R, Kaufman RJ. Mitochondria supply ATP to the ER through a mechanism antagonized by cytosolic Ca. Elife. 8. PMID 31498082 DOI: 10.7554/Elife.49682 |
0.319 |
|
| 2019 |
Jang I, Pottekat A, Poothong J, Yong J, Lagunas-Acosta J, Charbono A, Chen Z, Scheuner DL, Liu M, Itkin-Ansari P, Arvan P, Kaufman RJ. PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity. Elife. 8. PMID 31184304 DOI: 10.7554/Elife.44528 |
0.368 |
|
| 2019 |
Carreras-Sureda A, Jaña F, Urra H, Durand S, Mortenson DE, Sagredo A, Bustos G, Hazari Y, Ramos-Fernández E, Sassano ML, Pihán P, van Vliet AR, González-Quiroz M, Torres AK, Tapia-Rojas C, ... ... Kaufman RJ, et al. Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics. Nature Cell Biology. PMID 31110288 DOI: 10.1038/S41556-019-0329-Y |
0.316 |
|
| 2019 |
Cole DW, Svider PF, Shenouda KG, Lee PB, Yoo N, McLeod TM, Mutchnick S, Yoo GH, Kaufman RJ, Callaghan MU, Fribley AM. Targeting the unfolded protein response in head and neck and oral cavity cancers. Experimental Cell Research. PMID 31075256 DOI: 10.1016/J.Yexcr.2019.04.007 |
0.306 |
|
| 2019 |
Shah O'Brien P, Xi Y, Miller JR, Brownell AL, Zeng Q, Yoo GH, Garshott DM, O'Brien MB, Galinato AE, Cai P, Narula N, Callaghan MU, Kaufman RJ, Fribley AM. Disulfiram (Antabuse) Activates ROS-Dependent ER Stress and Apoptosis in Oral Cavity Squamous Cell Carcinoma. Journal of Clinical Medicine. 8. PMID 31064122 DOI: 10.3390/Jcm8050611 |
0.323 |
|
| 2019 |
Mimura J, Inose-Maruyama A, Taniuchi S, Kosaka K, Yoshida H, Yamazaki H, Kasai S, Harada N, Kaufman RJ, Oyadomari S, Itoh K. Concomitant Nrf2- and ATF4-activation by Carnosic Acid Cooperatively Induces Expression of Cytoprotective Genes. International Journal of Molecular Sciences. 20. PMID 30959808 DOI: 10.3390/Ijms20071706 |
0.344 |
|
| 2019 |
Zhu H, Bhatt B, Sivaprakasam S, Cai Y, Liu S, Kodeboyina SK, Patel N, Savage NM, Sharma A, Kaufman RJ, Li H, Singh N. Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR. Nature Communications. 10: 1084. PMID 30842412 DOI: 10.1038/S41467-019-08908-5 |
0.362 |
|
| 2018 |
Liu M, Weiss MA, Arunagiri A, Yong J, Rege N, Sun J, Haataja L, Kaufman RJ, Arvan P. Biosynthesis, structure, and folding of the insulin precursor protein. Diabetes, Obesity & Metabolism. 20: 28-50. PMID 30230185 DOI: 10.1111/Dom.13378 |
0.381 |
|
| 2018 |
Kim JY, Garcia-Carbonell R, Yamachika S, Zhao P, Dhar D, Loomba R, Kaufman RJ, Saltiel AR, Karin M. ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P. Cell. PMID 30220454 DOI: 10.1016/J.Cell.2018.08.020 |
0.423 |
|
| 2018 |
Wang JM, Qiu Y, Yang Z, Kim H, Qian Q, Sun Q, Zhang C, Yin L, Fang D, Back SH, Kaufman RJ, Yang L, Zhang K. IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs. Science Signaling. 11. PMID 29764990 DOI: 10.1126/Scisignal.Aao4617 |
0.307 |
|
| 2018 |
Pugach EK, Feltes M, Kaufman RJ, Ory DS, Bang AG. High-content screen for modifiers of Niemann-Pick Type C disease in patient cells. Human Molecular Genetics. PMID 29659804 DOI: 10.1093/Hmg/Ddy117 |
0.306 |
|
| 2017 |
Zhang S, Macias-Garcia A, Velazquez J, Paltrinieri E, Kaufman RJ, Chen JJ. HRI coordinates translation by eIF2αP and mTORC1 to mitigate ineffective erythropoiesis in mice during iron deficiency. Blood. PMID 29101239 DOI: 10.1182/Blood-2017-08-799908 |
0.374 |
|
| 2017 |
Chandrahas VK, Han J, Kaufman RJ. Coordinating Organismal Metabolism During Protein Misfolding in the ER Through the Unfolded Protein Response. Current Topics in Microbiology and Immunology. PMID 28900680 DOI: 10.1007/82_2017_41 |
0.486 |
|
| 2017 |
Han J, Kaufman RJ. Physiological/pathological ramifications of transcription factors in the unfolded protein response. Genes & Development. 31: 1417-1438. PMID 28860159 DOI: 10.1101/Gad.297374.117 |
0.492 |
|
| 2017 |
DeZwaan-McCabe D, Sheldon RD, Gorecki MC, Guo DF, Gansemer ER, Kaufman RJ, Rahmouni K, Gillum MP, Taylor EB, Teesch LM, Rutkowski DT. ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis. Cell Reports. 19: 1794-1806. PMID 28564599 DOI: 10.1016/J.Celrep.2017.05.020 |
0.741 |
|
| 2017 |
Poothong J, Tirasophon W, Kaufman RJ. Functional analysis of the mammalian RNA ligase for IRE1 in the unfolded protein response. Bioscience Reports. PMID 28093457 DOI: 10.1042/Bsr20160574 |
0.458 |
|
| 2016 |
Chiang WC, Chan P, Wissinger B, Vincent A, Skorczyk-Werner A, Krawczyński MR, Kaufman RJ, Tsang SH, Héon E, Kohl S, Lin JH. Achromatopsia mutations target sequential steps of ATF6 activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 28028229 DOI: 10.1073/Pnas.1606387114 |
0.449 |
|
| 2016 |
Poothong J, Sopha P, Kaufman RJ, Tirasophon W. IRE1α nucleotide sequence cleavage specificity in the unfolded protein response. Febs Letters. PMID 28027394 DOI: 10.1002/1873-3468.12546 |
0.372 |
|
| 2016 |
Jin JK, Blackwood EA, Azizi KM, Thuerauf DJ, Fahem AG, Hofmann C, Kaufman RJ, Doroudgar S, Glembotski CC. ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart. Circulation Research. PMID 27932512 DOI: 10.1161/Circresaha.116.310266 |
0.449 |
|
| 2016 |
Oubaha M, Miloudi K, Dejda A, Guber V, Mawambo G, Germain MA, Bourdel G, Popovic N, Rezende FA, Kaufman RJ, Mallette FA, Sapieha P. Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy. Science Translational Medicine. 8: 362ra144. PMID 27797960 DOI: 10.1126/Scitranslmed.Aaf9440 |
0.322 |
|
| 2016 |
Bai Y, Kinne J, Donham B, Jiang F, Ding L, Hassler JR, Kaufman RJ. Read-Split-Run: an improved bioinformatics pipeline for identification of genome-wide non-canonical spliced regions using RNA-Seq data. Bmc Genomics. 17: 503. PMID 27556805 DOI: 10.1186/S12864-016-2896-7 |
0.373 |
|
| 2016 |
Grootjans J, Kaser A, Kaufman RJ, Blumberg RS. The unfolded protein response in immunity and inflammation. Nature Reviews. Immunology. PMID 27346803 DOI: 10.1038/Nri.2016.62 |
0.354 |
|
| 2016 |
Yang L, Li S, Miao L, Huang H, Liang F, Teng X, Xu L, Wang Q, Xiao W, Ridder WH, Ferguson TA, Chen DF, Kaufman RJ, Hu Y. Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal Endoplasmic Reticulum Stress Molecules. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 5891-903. PMID 27225776 DOI: 10.1523/Jneurosci.3709-15.2016 |
0.34 |
|
| 2016 |
Han J, Kaufman RJ. The role of ER stress in lipid metabolism and lipotoxicity. Journal of Lipid Research. PMID 27146479 DOI: 10.1194/Jlr.R067595 |
0.463 |
|
| 2016 |
Ravindran R, Loebbermann J, Nakaya HI, Khan N, Ma H, Gama L, Machiah DK, Lawson B, Hakimpour P, Wang YC, Li S, Sharma P, Kaufman RJ, Martinez J, Pulendran B. The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation. Nature. PMID 26982722 DOI: 10.1038/Nature17186 |
0.343 |
|
| 2016 |
Mollereau B, Rzechorzek NM, Roussel BD, Sedru M, Van den Brink D, Bailly-Maitre B, Palladino F, Medinas DB, Domingos PM, Hunot S, Chandran S, Birman S, Baron T, Vivien D, Duarte CB, ... ... Kaufman RJ, et al. Adaptive Preconditioning in Neurological Diseases - Therapeutic Insights from Proteostatic Perturbations. Brain Research. PMID 26923166 DOI: 10.1016/J.Brainres.2016.02.033 |
0.399 |
|
| 2016 |
Wang M, Kaufman RJ. Protein misfolding in the endoplasmic reticulum as a conduit to human disease. Nature. 529: 326-35. PMID 26791723 DOI: 10.1038/Nature17041 |
0.47 |
|
| 2016 |
Yong J, Itkin-Ansari P, Kaufman RJ. When Less Is Better: ER Stress and Beta Cell Proliferation. Developmental Cell. 36: 4-6. PMID 26766438 DOI: 10.1016/J.Devcel.2015.12.030 |
0.345 |
|
| 2015 |
Sidhu A, Miller JR, Tripathi A, Garshott DM, Brownell AL, Chiego DJ, Arevang C, Zeng Q, Jackson LC, Bechler SA, Callaghan MU, Yoo GH, Sethi S, Lin HS, Callaghan JH, ... ... Kaufman RJ, et al. Borrelidin Induces the Unfolded Protein Response in Oral Cancer Cells and Chop-Dependent Apoptosis. Acs Medicinal Chemistry Letters. 6: 1122-1127. PMID 26617965 DOI: 10.1021/Acsmedchemlett.5B00133 |
0.401 |
|
| 2015 |
Hassler JR, Scheuner DL, Wang S, Han J, Kodali VK, Li P, Nguyen J, George JS, Davis C, Wu SP, Bai Y, Sartor M, Cavalcoli J, Malhi H, Baudouin G, ... ... Kaufman RJ, et al. The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells. Plos Biology. 13: e1002277. PMID 26469762 DOI: 10.1371/Journal.Pbio.1002277 |
0.372 |
|
| 2015 |
Cruz PG, Fribley AM, Miller JR, Larsen MJ, Schultz PJ, Jacob RT, Tamayo-Castillo G, Kaufman RJ, Sherman DH. Novel Lobophorins Inhibit Oral Cancer Cell Growth and Induce Atf4- and Chop-Dependent Cell Death in Murine Fibroblasts. Acs Medicinal Chemistry Letters. 6: 877-81. PMID 26288688 DOI: 10.1021/Acsmedchemlett.5B00127 |
0.339 |
|
| 2015 |
von Hoven G, Neukirch C, Meyenburg M, Füser S, Petrivna MB, Rivas AJ, Ryazanov A, Kaufman RJ, Aroian RV, Husmann M. eIF2α Confers Cellular Tolerance to S. aureus α-Toxin. Frontiers in Immunology. 6: 383. PMID 26284068 DOI: 10.3389/Fimmu.2015.00383 |
0.375 |
|
| 2015 |
D'Osualdo A, Anania VG, Yu K, Lill JR, Kaufman RJ, Matsuzawa S, Reed JC. Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress. Plos One. 10: e0130635. PMID 26086088 DOI: 10.1371/Journal.Pone.0130635 |
0.486 |
|
| 2015 |
Kohl S, Zobor D, Chiang WC, Weisschuh N, Staller J, Gonzalez Menendez I, Chang S, Beck SC, Garcia Garrido M, Sothilingam V, Seeliger MW, Stanzial F, Benedicenti F, Inzana F, Héon E, ... ... Kaufman RJ, et al. Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia. Nature Genetics. 47: 757-65. PMID 26029869 DOI: 10.1038/Ng.3319 |
0.385 |
|
| 2015 |
Zhou AX, Wang X, Lin CS, Han J, Yong J, Nadolski MJ, Borén J, Kaufman RJ, Tabas I. C/EBP-Homologous Protein (CHOP) in Vascular Smooth Muscle Cells Regulates Their Proliferation in Aortic Explants and Atherosclerotic Lesions. Circulation Research. 116: 1736-43. PMID 25872946 DOI: 10.1161/Circresaha.116.305602 |
0.366 |
|
| 2015 |
Han J, Song B, Kim J, Kodali VK, Pottekat A, Wang M, Hassler J, Wang S, Pennathur S, Back SH, Katze MG, Kaufman RJ. Antioxidants complement the requirement for protein chaperone function to maintain beta cell function and glucose homeostasis. Diabetes. PMID 25795214 DOI: 10.2337/Db14-1357 |
0.399 |
|
| 2015 |
Wang S, Park S, Kodali VK, Han J, Yip T, Chen Z, Davidson NO, Kaufman RJ. Identification of protein disulfide isomerase 1 as a key isomerase for disulfide bond formation in apolipoprotein B100. Molecular Biology of the Cell. 26: 594-604. PMID 25518935 DOI: 10.1091/Mbc.E14-08-1274 |
0.499 |
|
| 2015 |
Xi Y, Garshott DM, Brownell AL, Yoo GH, Lin HS, Freeburg TL, Yoo NG, Kaufman RJ, Callaghan MU, Fribley AM. Cantharidins induce ER stress and a terminal unfolded protein response in OSCC. Journal of Dental Research. 94: 320-9. PMID 25425581 DOI: 10.1177/0022034514559376 |
0.446 |
|
| 2015 |
Genereux JC, Qu S, Zhou M, Ryno LM, Wang S, Shoulders MD, Kaufman RJ, Lasmézas CI, Kelly JW, Wiseman RL. Unfolded protein response-induced ERdj3 secretion links ER stress to extracellular proteostasis. The Embo Journal. 34: 4-19. PMID 25361606 DOI: 10.15252/Embj.201488896 |
0.472 |
|
| 2015 |
Fribley AM, Miller JR, Brownell AL, Garshott DM, Zeng Q, Reist TE, Narula N, Cai P, Xi Y, Callaghan MU, Kodali V, Kaufman RJ. Celastrol induces unfolded protein response-dependent cell death in head and neck cancer. Experimental Cell Research. 330: 412-22. PMID 25139619 DOI: 10.1016/J.Yexcr.2014.08.014 |
0.389 |
|
| 2014 |
Yong J, Grankvist N, Han J, Kaufman RJ. Eukaryotic translation initiation factor 2 α phosphorylation as a therapeutic target in diabetes. Expert Review of Endocrinology & Metabolism. 9: 345-356. PMID 30763994 DOI: 10.1586/17446651.2014.927309 |
0.386 |
|
| 2014 |
Flaherty DP, Miller JR, Garshott DM, Hedrick M, Gosalia P, Li Y, Milewski M, Sugarman E, Vasile S, Salaniwal S, Su Y, Smith LH, Chung TD, Pinkerton AB, Aubé J, ... ... Kaufman RJ, et al. Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response. Acs Medicinal Chemistry Letters. 5: 1278-1283. PMID 25530830 DOI: 10.1021/Ml5003234 |
0.439 |
|
| 2014 |
Wang M, Kaufman RJ. The impact of the endoplasmic reticulum protein-folding environment on cancer development. Nature Reviews. Cancer. 14: 581-97. PMID 25145482 DOI: 10.1038/Nrc3800 |
0.463 |
|
| 2014 |
Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, Koike K, Kaufman RJ, Karin M. ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell. 26: 331-43. PMID 25132496 DOI: 10.1016/J.Ccr.2014.07.001 |
0.352 |
|
| 2014 |
Mao HZ, Ehrhardt N, Bedoya C, Gomez JA, DeZwaan-McCabe D, Mungrue IN, Kaufman RJ, Rutkowski DT, Péterfy M. Lipase maturation factor 1 (lmf1) is induced by endoplasmic reticulum stress through activating transcription factor 6α (Atf6α) signaling. The Journal of Biological Chemistry. 289: 24417-27. PMID 25035425 DOI: 10.1074/Jbc.M114.588764 |
0.823 |
|
| 2014 |
Sadleir KR, Eimer WA, Kaufman RJ, Osten P, Vassar R. Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease. Plos One. 9: e101643. PMID 24992504 DOI: 10.1371/Journal.Pone.0101643 |
0.341 |
|
| 2014 |
Bai Y, Hassler J, Ziyar A, Li P, Wright Z, Menon R, Omenn GS, Cavalcoli JD, Kaufman RJ, Sartor MA. Novel bioinformatics method for identification of genome-wide non-canonical spliced regions using RNA-Seq data. Plos One. 9: e100864. PMID 24991935 DOI: 10.1371/Journal.Pone.0100864 |
0.448 |
|
| 2014 |
Di Prisco GV, Huang W, Buffington SA, Hsu CC, Bonnen PE, Placzek AN, Sidrauski C, Krnjević K, Kaufman RJ, Walter P, Costa-Mattioli M. Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α. Nature Neuroscience. 17: 1073-82. PMID 24974795 DOI: 10.1038/Nn.3754 |
0.303 |
|
| 2014 |
Groenendyk J, Peng Z, Dudek E, Fan X, Mizianty MJ, Dufey E, Urra H, Sepulveda D, Rojas-Rivera D, Lim Y, Kim do H, Baretta K, Srikanth S, Gwack Y, Ahnn J, ... Kaufman RJ, et al. Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis. Science Signaling. 7: ra54. PMID 24917591 DOI: 10.1126/Scisignal.2004983 |
0.442 |
|
| 2014 |
Scortegagna M, Kim H, Li JL, Yao H, Brill LM, Han J, Lau E, Bowtell D, Haddad G, Kaufman RJ, Ronai ZA. Fine tuning of the UPR by the ubiquitin ligases Siah1/2. Plos Genetics. 10: e1004348. PMID 24809345 DOI: 10.1371/Journal.Pgen.1004348 |
0.46 |
|
| 2014 |
Cao SS, Kaufman RJ. Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. Antioxidants & Redox Signaling. 21: 396-413. PMID 24702237 DOI: 10.1089/Ars.2014.5851 |
0.459 |
|
| 2014 |
Hiramatsu N, Messah C, Han J, LaVail MM, Kaufman RJ, Lin JH. Translational and posttranslational regulation of XIAP by eIF2α and ATF4 promotes ER stress-induced cell death during the unfolded protein response. Molecular Biology of the Cell. 25: 1411-20. PMID 24623724 DOI: 10.1091/Mbc.E13-11-0664 |
0.484 |
|
| 2014 |
Ferris SP, Kodali VK, Kaufman RJ. Glycoprotein folding and quality-control mechanisms in protein-folding diseases. Disease Models & Mechanisms. 7: 331-41. PMID 24609034 DOI: 10.1242/Dmm.014589 |
0.385 |
|
| 2014 |
Cao SS, Wang M, Harrington JC, Chuang BM, Eckmann L, Kaufman RJ. Phosphorylation of eIF2α is dispensable for differentiation but required at a posttranscriptional level for paneth cell function and intestinal homeostasis in mice. Inflammatory Bowel Diseases. 20: 712-22. PMID 24577114 DOI: 10.1097/Mib.0000000000000010 |
0.363 |
|
| 2014 |
Wang S, Kaufman RJ. How does protein misfolding in the endoplasmic reticulum affect lipid metabolism in the liver? Current Opinion in Lipidology. 25: 125-32. PMID 24565920 DOI: 10.1097/Mol.0000000000000056 |
0.328 |
|
| 2014 |
Han J, Kaufman RJ. Measurement of the unfolded protein response to investigate its role in adipogenesis and obesity. Methods in Enzymology. 538: 135-50. PMID 24529437 DOI: 10.1016/B978-0-12-800280-3.00008-6 |
0.446 |
|
| 2014 |
Wang M, Kaufman RJ. Abstract SY44-03: Targeting the unfolded protein response in cancer Cancer Research. 74. DOI: 10.1158/1538-7445.Am2014-Sy44-03 |
0.498 |
|
| 2013 |
Arensdorf AM, Dezwaan McCabe D, Kaufman RJ, Rutkowski DT. Temporal clustering of gene expression links the metabolic transcription factor HNF4α to the ER stress-dependent gene regulatory network. Frontiers in Genetics. 4: 188. PMID 24069029 DOI: 10.3389/Fgene.2013.00188 |
0.808 |
|
| 2013 |
Sakaki K, Kaufman RJ. Interaction between quality control systems for ER protein folding and RNA biogenesis. Worm. 2: e23005. PMID 24058870 DOI: 10.4161/worm.23005 |
0.346 |
|
| 2013 |
Ferris SP, Jaber NS, Molinari M, Arvan P, Kaufman RJ. UDP-glucose:glycoprotein glucosyltransferase (UGGT1) promotes substrate solubility in the endoplasmic reticulum. Molecular Biology of the Cell. 24: 2597-608. PMID 23864712 DOI: 10.1091/Mbc.E13-02-0101 |
0.417 |
|
| 2013 |
Landau G, Kodali VK, Malhotra JD, Kaufman RJ. Detection of oxidative damage in response to protein misfolding in the endoplasmic reticulum. Methods in Enzymology. 526: 231-50. PMID 23791104 DOI: 10.1016/B978-0-12-405883-5.00014-4 |
0.413 |
|
| 2013 |
Malhi H, Kropp EM, Clavo VF, Kobrossi CR, Han J, Mauer AS, Yong J, Kaufman RJ. C/EBP homologous protein-induced macrophage apoptosis protects mice from steatohepatitis. The Journal of Biological Chemistry. 288: 18624-42. PMID 23720735 DOI: 10.1074/Jbc.M112.442954 |
0.31 |
|
| 2013 |
Misra J, Kim DK, Choi W, Koo SH, Lee CH, Back SH, Kaufman RJ, Choi HS. Transcriptional cross talk between orphan nuclear receptor ERRγ and transmembrane transcription factor ATF6α coordinates endoplasmic reticulum stress response. Nucleic Acids Research. 41: 6960-74. PMID 23716639 DOI: 10.1093/Nar/Gkt429 |
0.386 |
|
| 2013 |
Krokowski D, Han J, Saikia M, Majumder M, Yuan CL, Guan BJ, Bevilacqua E, Bussolati O, Bröer S, Arvan P, Tchórzewski M, Snider MD, Puchowicz M, Croniger CM, Kimball SR, ... ... Kaufman RJ, et al. A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux. The Journal of Biological Chemistry. 288: 17202-13. PMID 23645676 DOI: 10.1074/Jbc.M113.466920 |
0.424 |
|
| 2013 |
Han J, Back SH, Hur J, Lin YH, Gildersleeve R, Shan J, Yuan CL, Krokowski D, Wang S, Hatzoglou M, Kilberg MS, Sartor MA, Kaufman RJ. ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nature Cell Biology. 15: 481-90. PMID 23624402 DOI: 10.1038/Ncb2738 |
0.491 |
|
| 2013 |
Binet F, Mawambo G, Sitaras N, Tetreault N, Lapalme E, Favret S, Cerani A, Leboeuf D, Tremblay S, Rezende F, Juan AM, Stahl A, Joyal JS, Milot E, Kaufman RJ, et al. Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1α degradation of netrin-1. Cell Metabolism. 17: 353-71. PMID 23473031 DOI: 10.1016/J.Cmet.2013.02.003 |
0.358 |
|
| 2013 |
Cao SS, Zimmermann EM, Chuang BM, Song B, Nwokoye A, Wilkinson JE, Eaton KA, Kaufman RJ. The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice. Gastroenterology. 144: 989-1000.e6. PMID 23336977 DOI: 10.1053/J.Gastro.2013.01.023 |
0.45 |
|
| 2013 |
Cao SS, Kaufman RJ. Targeting endoplasmic reticulum stress in metabolic disease. Expert Opinion On Therapeutic Targets. 17: 437-48. PMID 23324104 DOI: 10.1517/14728222.2013.756471 |
0.396 |
|
| 2013 |
Han J, Murthy R, Wood B, Song B, Wang S, Sun B, Malhi H, Kaufman RJ. ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice. Diabetologia. 56: 911-24. PMID 23314846 DOI: 10.1007/s00125-012-2809-5 |
0.323 |
|
| 2013 |
Koromilas AE, Kamindla R, Papadakis AI, Kazimierczak U, Peidis P, Wang S, Tenkerian C, Krishnamoorthy J, Hatzoglou M, Haj FG, Ferbeyre G, Kaufman RJ. Abstract C51: eIF2alpha phosphorylation determines cell susceptibility to oxidative stress via Akt activation. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-C51 |
0.394 |
|
| 2013 |
Malhi H, Mauer AS, Han J, Yong J, Kaufman RJ. 458 C/EBP Homologous Protein (CHOP) Mediates Macrophage Apoptosis in Nonalcoholic Steatohepatitis Leading to Dampened Inflammation Gastroenterology. 144: S-948. DOI: 10.1016/S0016-5085(13)63526-X |
0.314 |
|
| 2012 |
Hassler J, Cao SS, Kaufman RJ. IRE1, a double-edged sword in pre-miRNA slicing and cell death. Developmental Cell. 23: 921-3. PMID 23153490 DOI: 10.1016/J.Devcel.2012.10.025 |
0.368 |
|
| 2012 |
Wang S, Chen Z, Lam V, Han J, Hassler J, Finck BN, Davidson NO, Kaufman RJ. IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis. Cell Metabolism. 16: 473-86. PMID 23040069 DOI: 10.1016/J.Cmet.2012.09.003 |
0.397 |
|
| 2012 |
Cao SS, Kaufman RJ. Unfolded protein response. Current Biology : Cb. 22: R622-6. PMID 22917505 DOI: 10.1016/J.Cub.2012.07.004 |
0.449 |
|
| 2012 |
Oslowski CM, Hara T, O'Sullivan-Murphy B, Kanekura K, Lu S, Hara M, Ishigaki S, Zhu LJ, Hayashi E, Hui ST, Greiner D, Kaufman RJ, Bortell R, Urano F. Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metabolism. 16: 265-73. PMID 22883234 DOI: 10.1016/J.Cmet.2012.07.005 |
0.429 |
|
| 2012 |
Wang S, Kaufman RJ. The impact of the unfolded protein response on human disease. The Journal of Cell Biology. 197: 857-67. PMID 22733998 DOI: 10.1083/Jcb.201110131 |
0.415 |
|
| 2012 |
Yung HW, Hemberger M, Watson ED, Senner CE, Jones CP, Kaufman RJ, Charnock-Jones DS, Burton GJ. Endoplasmic reticulum stress disrupts placental morphogenesis: implications for human intrauterine growth restriction. The Journal of Pathology. 228: 554-64. PMID 22733590 DOI: 10.1002/Path.4068 |
0.437 |
|
| 2012 |
Gilbert GE, Novakovic VA, Kaufman RJ, Miao H, Pipe SW. Conservative mutations in the C2 domains of factor VIII and factor V alter phospholipid binding and cofactor activity. Blood. 120: 1923-32. PMID 22613792 DOI: 10.1182/Blood-2012-01-408245 |
0.301 |
|
| 2012 |
Sakaki K, Yoshina S, Shen X, Han J, DeSantis MR, Xiong M, Mitani S, Kaufman RJ. RNA surveillance is required for endoplasmic reticulum homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 109: 8079-84. PMID 22562797 DOI: 10.1073/Pnas.1110589109 |
0.657 |
|
| 2012 |
Back SH, Kaufman RJ. Endoplasmic reticulum stress and type 2 diabetes. Annual Review of Biochemistry. 81: 767-93. PMID 22443930 DOI: 10.1146/Annurev-Biochem-072909-095555 |
0.424 |
|
| 2012 |
Cao SS, Song B, Kaufman RJ. PKR protects colonic epithelium against colitis through the unfolded protein response and prosurvival signaling. Inflammatory Bowel Diseases. 18: 1735-42. PMID 22275310 DOI: 10.1002/Ibd.22878 |
0.406 |
|
| 2012 |
Dickhout JG, Carlisle RE, Jerome DE, Mohammed-Ali Z, Jiang H, Yang G, Mani S, Garg SK, Banerjee R, Kaufman RJ, Maclean KN, Wang R, Austin RC. Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism. The Journal of Biological Chemistry. 287: 7603-14. PMID 22215680 DOI: 10.1074/Jbc.M111.304576 |
0.468 |
|
| 2012 |
Majumder M, Huang C, Snider MD, Komar AA, Tanaka J, Kaufman RJ, Krokowski D, Hatzoglou M. A novel feedback loop regulates the response to endoplasmic reticulum stress via the cooperation of cytoplasmic splicing and mRNA translation. Molecular and Cellular Biology. 32: 992-1003. PMID 22215619 DOI: 10.1128/Mcb.06665-11 |
0.503 |
|
| 2012 |
Zhang C, Wang G, Zheng Z, Maddipati KR, Zhang X, Dyson G, Williams P, Duncan SA, Kaufman RJ, Zhang K. Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice. Hepatology (Baltimore, Md.). 55: 1070-82. PMID 22095841 DOI: 10.1002/Hep.24783 |
0.382 |
|
| 2012 |
Selvaraj SR, Scheller AN, Miao HZ, Kaufman RJ, Pipe SW. Bioengineering of coagulation factor VIII for efficient expression through elimination of a dispensable disulfide loop Journal of Thrombosis and Haemostasis. 10: 107-115. PMID 22044596 DOI: 10.1111/J.1538-7836.2011.04545.X |
0.345 |
|
| 2012 |
Cao S, Kaufman RJ. Sa1872 The Unfolded Protein Response-Activated Chaperone Expression in Inflammatory Bowel Disease: Exploring the Therapeutic Potential of Chemical Chaperones Gastroenterology. 142: S-346. DOI: 10.1016/S0016-5085(12)61307-9 |
0.338 |
|
| 2011 |
Kaufman RJ. Beta-cell failure, stress, and type 2 diabetes. The New England Journal of Medicine. 365: 1931-3. PMID 22087686 DOI: 10.1056/Nejmcibr1109442 |
0.32 |
|
| 2011 |
Fribley AM, Cruz PG, Miller JR, Callaghan MU, Cai P, Narula N, Neubig RR, Showalter HD, Larsen SD, Kirchhoff PD, Larsen MJ, Burr DA, Schultz PJ, Jacobs RR, Tamayo-Castillo G, ... ... Kaufman RJ, et al. Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response. Journal of Biomolecular Screening. 16: 825-35. PMID 21844328 DOI: 10.1177/1087057111414893 |
0.364 |
|
| 2011 |
Malhotra JD, Kaufman RJ. ER stress and its functional link to mitochondria: role in cell survival and death. Cold Spring Harbor Perspectives in Biology. 3: a004424. PMID 21813400 DOI: 10.1101/Cshperspect.A004424 |
0.465 |
|
| 2011 |
Zhang B, Zheng C, Zhu M, Tao J, Vasievich MP, Baines A, Kim J, Schekman R, Kaufman RJ, Ginsburg D. Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin. Blood. 118: 3384-91. PMID 21795745 DOI: 10.1182/Blood-2011-05-352815 |
0.345 |
|
| 2011 |
Gao N, Shang J, Huynh D, Manthati VL, Arias C, Harding HP, Kaufman RJ, Mohr I, Ron D, Falck JR, Lehrman MA. Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides. Molecular Biology of the Cell. 22: 2994-3009. PMID 21737679 DOI: 10.1091/Mbc.E11-04-0286 |
0.423 |
|
| 2011 |
Cao SS, Kaufman RJ. iRhoms: ERADicating the messenger in growth control signaling. Developmental Cell. 20: 414-6. PMID 21497754 DOI: 10.1016/J.Devcel.2011.04.003 |
0.33 |
|
| 2011 |
Zhang K, Wang S, Malhotra J, Hassler JR, Back SH, Wang G, Chang L, Xu W, Miao H, Leonardi R, Chen YE, Jackowski S, Kaufman RJ. The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis. The Embo Journal. 30: 1357-75. PMID 21407177 DOI: 10.1038/Emboj.2011.52 |
0.503 |
|
| 2011 |
Wu J, Ruas JL, Estall JL, Rasbach KA, Choi JH, Ye L, Boström P, Tyra HM, Crawford RW, Campbell KP, Rutkowski DT, Kaufman RJ, Spiegelman BM. The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex. Cell Metabolism. 13: 160-9. PMID 21284983 DOI: 10.1016/J.Cmet.2011.01.003 |
0.743 |
|
| 2011 |
Malhi H, Kaufman RJ. Endoplasmic reticulum stress in liver disease. Journal of Hepatology. 54: 795-809. PMID 21145844 DOI: 10.1016/J.Jhep.2010.11.005 |
0.502 |
|
| 2010 |
Kaufman RJ, Back SH, Song B, Han J, Hassler J. The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells. Diabetes, Obesity & Metabolism. 12: 99-107. PMID 21029306 DOI: 10.1111/J.1463-1326.2010.01281.X |
0.424 |
|
| 2010 |
Muaddi H, Majumder M, Peidis P, Papadakis AI, Holcik M, Scheuner D, Kaufman RJ, Hatzoglou M, Koromilas AE. Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency. Molecular Biology of the Cell. 21: 3220-31. PMID 20660158 DOI: 10.1091/Mbc.E10-01-0023 |
0.391 |
|
| 2010 |
Poothong J, Sopha P, Kaufman RJ, Tirasophon W. Domain compatibility in Ire1 kinase is critical for the unfolded protein response. Febs Letters. 584: 3203-8. PMID 20541549 DOI: 10.1016/J.Febslet.2010.06.003 |
0.388 |
|
| 2010 |
Kaufman RJ, Cao S. Inositol-requiring 1/X-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism. Embo Molecular Medicine. 2: 189-92. PMID 20533428 DOI: 10.1002/Emmm.201000076 |
0.348 |
|
| 2010 |
Pearse BR, Tamura T, Sunryd JC, Grabowski GA, Kaufman RJ, Hebert DN. The role of UDP-Glc:glycoprotein glucosyltransferase 1 in the maturation of an obligate substrate prosaposin. The Journal of Cell Biology. 189: 829-41. PMID 20498017 DOI: 10.1083/Jcb.200912105 |
0.382 |
|
| 2010 |
Schulz O, Pichlmair A, Rehwinkel J, Rogers NC, Scheuner D, Kato H, Takeuchi O, Akira S, Kaufman RJ, Reis e Sousa C. Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity. Cell Host & Microbe. 7: 354-61. PMID 20478537 DOI: 10.1016/J.Chom.2010.04.007 |
0.302 |
|
| 2010 |
Huang CC, Li Y, Lopez AB, Chiang CM, Kaufman RJ, Snider MD, Hatzoglou M. Temporal regulation of Cat-1 (cationic amino acid transporter-1) gene transcription during endoplasmic reticulum stress. The Biochemical Journal. 429: 215-24. PMID 20408811 DOI: 10.1042/Bj20100286 |
0.472 |
|
| 2010 |
Bevilacqua E, Wang X, Majumder M, Gaccioli F, Yuan CL, Wang C, Zhu X, Jordan LE, Scheuner D, Kaufman RJ, Koromilas AE, Snider MD, Holcik M, Hatzoglou M. eIF2alpha phosphorylation tips the balance to apoptosis during osmotic stress. The Journal of Biological Chemistry. 285: 17098-111. PMID 20338999 DOI: 10.1074/Jbc.M110.109439 |
0.405 |
|
| 2010 |
Qiu Y, Mao T, Zhang Y, Shao M, You J, Ding Q, Chen Y, Wu D, Xie D, Lin X, Gao X, Kaufman RJ, Li W, Liu Y. A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells. Science Signaling. 3: ra7. PMID 20103773 DOI: 10.1126/Scisignal.2000514 |
0.367 |
|
| 2010 |
Minor RA, Limmon GV, Miller-DeGraff L, Dixon D, Andrews DM, Kaufman RJ, Imani F. Double-stranded RNA-activated protein kinase regulates early innate immune responses during respiratory syncytial virus infection. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 30: 263-72. PMID 20038207 DOI: 10.1089/Jir.2009.0051 |
0.308 |
|
| 2010 |
Malhotra J, Xiong M, Miao H, Pipe S, Kaufman RJ. Endoplasmic Reticulum to Mitochondria Ca2+ Signaling Inhibits Factor VIII Secretion and Mediates Oxidative Stress and Apoptosis Upon Factor VIII Expression Blood. 116: 2212-2212. DOI: 10.1182/Blood.V116.21.2212.2212 |
0.433 |
|
| 2009 |
Mounir Z, Krishnamoorthy JL, Robertson GP, Scheuner D, Kaufman RJ, Georgescu MM, Koromilas AE. Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway. Science Signaling. 2: ra85. PMID 20029030 DOI: 10.1126/Scisignal.2000389 |
0.352 |
|
| 2009 |
Vecchi C, Montosi G, Zhang K, Lamberti I, Duncan SA, Kaufman RJ, Pietrangelo A. ER stress controls iron metabolism through induction of hepcidin. Science (New York, N.Y.). 325: 877-80. PMID 19679815 DOI: 10.1126/Science.1176639 |
0.422 |
|
| 2009 |
Fribley A, Zhang K, Kaufman RJ. Regulation of apoptosis by the unfolded protein response. Methods in Molecular Biology (Clifton, N.J.). 559: 191-204. PMID 19609758 DOI: 10.1007/978-1-60327-017-5_14 |
0.484 |
|
| 2009 |
Back SH, Scheuner D, Han J, Song B, Ribick M, Wang J, Gildersleeve RD, Pennathur S, Kaufman RJ. Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. Cell Metabolism. 10: 13-26. PMID 19583950 DOI: 10.1016/J.Cmet.2009.06.002 |
0.402 |
|
| 2009 |
DuRose JB, Scheuner D, Kaufman RJ, Rothblum LI, Niwa M. Phosphorylation of eukaryotic translation initiation factor 2alpha coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress. Molecular and Cellular Biology. 29: 4295-307. PMID 19470760 DOI: 10.1128/Mcb.00260-09 |
0.48 |
|
| 2009 |
Davies MJ, Miranda E, Roussel BD, Kaufman RJ, Marciniak SJ, Lomas DA. Neuroserpin polymers activate NF-kappaB by a calcium signaling pathway that is independent of the unfolded protein response. The Journal of Biological Chemistry. 284: 18202-9. PMID 19423713 DOI: 10.1074/Jbc.M109.010744 |
0.378 |
|
| 2009 |
Bommiasamy H, Back SH, Fagone P, Lee K, Meshinchi S, Vink E, Sriburi R, Frank M, Jackowski S, Kaufman RJ, Brewer JW. ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum. Journal of Cell Science. 122: 1626-36. PMID 19420237 DOI: 10.1242/Jcs.045625 |
0.475 |
|
| 2009 |
Mokas S, Mills JR, Garreau C, Fournier MJ, Robert F, Arya P, Kaufman RJ, Pelletier J, Mazroui R. Uncoupling stress granule assembly and translation initiation inhibition. Molecular Biology of the Cell. 20: 2673-83. PMID 19369421 DOI: 10.1091/Mbc.E08-10-1061 |
0.436 |
|
| 2009 |
Harding HP, Zhang Y, Scheuner D, Chen JJ, Kaufman RJ, Ron D. Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development. Proceedings of the National Academy of Sciences of the United States of America. 106: 1832-7. PMID 19181853 DOI: 10.1073/Pnas.0809632106 |
0.445 |
|
| 2009 |
Wang J, Farr GW, Zeiss CJ, Rodriguez-Gil DJ, Wilson JH, Furtak K, Rutkowski DT, Kaufman RJ, Ruse CI, Yates JR, Perrin S, Feany MB, Horwich AL. Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS. Proceedings of the National Academy of Sciences of the United States of America. 106: 1392-7. PMID 19171884 DOI: 10.1073/Pnas.0813045106 |
0.682 |
|
| 2009 |
Back SH, Hassler JR, Kaufman RJ. The unfolded protein response in mammalian cells Protein Misfolding Disorders: a Trip Into the Er. 19-46. DOI: 10.2174/978160805013010901010019 |
0.363 |
|
| 2009 |
Kaufman RJ. Factor VIII Biosynthesis and the Unfolded Protein Response. Blood. 114: SCI-19-SCI-19. DOI: 10.1182/Blood.V114.22.Sci-19.Sci-19 |
0.466 |
|
| 2008 |
Rutkowski DT, Wu J, Back SH, Callaghan MU, Ferris SP, Iqbal J, Clark R, Miao H, Hassler JR, Fornek J, Katze MG, Hussain MM, Song B, Swathirajan J, Wang J, ... ... Kaufman RJ, et al. UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Developmental Cell. 15: 829-40. PMID 19081072 DOI: 10.1016/J.Devcel.2008.10.015 |
0.769 |
|
| 2008 |
Malhotra JD, Miao H, Zhang K, Wolfson A, Pennathur S, Pipe SW, Kaufman RJ. Antioxidants reduce endoplasmic reticulum stress and improve protein secretion. Proceedings of the National Academy of Sciences of the United States of America. 105: 18525-30. PMID 19011102 DOI: 10.1073/Pnas.0809677105 |
0.454 |
|
| 2008 |
Kim J, Choi TG, Ding Y, Kim Y, Ha KS, Lee KH, Kang I, Ha J, Kaufman RJ, Lee J, Choe W, Kim SS. Overexpressed cyclophilin B suppresses apoptosis associated with ROS and Ca2+ homeostasis after ER stress. Journal of Cell Science. 121: 3636-48. PMID 18946027 DOI: 10.1242/Jcs.028654 |
0.473 |
|
| 2008 |
Song B, Scheuner D, Ron D, Pennathur S, Kaufman RJ. Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. The Journal of Clinical Investigation. 118: 3378-89. PMID 18776938 DOI: 10.1172/Jci34587 |
0.4 |
|
| 2008 |
Luebke-Wheeler J, Zhang K, Battle M, Si-Tayeb K, Garrison W, Chhinder S, Li J, Kaufman RJ, Duncan SA. Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H. Hepatology (Baltimore, Md.). 48: 1242-50. PMID 18704925 DOI: 10.1002/Hep.22439 |
0.415 |
|
| 2008 |
Sakaki K, Kaufman RJ. Regulation of ER stress-induced macroautophagy by protein kinase C. Autophagy. 4: 841-3. PMID 18670192 DOI: 10.4161/Auto.6607 |
0.503 |
|
| 2008 |
Yamamoto K, Suzuki N, Wada T, Okada T, Yoshida H, Kaufman RJ, Mori K. Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds. Journal of Biochemistry. 144: 477-86. PMID 18664523 DOI: 10.1093/Jb/Mvn091 |
0.446 |
|
| 2008 |
Zhang K, Kaufman RJ. Chapter Twenty Identification and Characterization of Endoplasmic Reticulum Stress-Induced Apoptosis In Vivo Methods in Enzymology. 442: 395-419. PMID 18662581 DOI: 10.1016/S0076-6879(08)01420-1 |
0.48 |
|
| 2008 |
Farhan H, Weiss M, Tani K, Kaufman RJ, Hauri HP. Adaptation of endoplasmic reticulum exit sites to acute and chronic increases in cargo load. The Embo Journal. 27: 2043-54. PMID 18650939 DOI: 10.1038/Emboj.2008.136 |
0.381 |
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| 2008 |
Zhang K, Kaufman RJ. From endoplasmic-reticulum stress to the inflammatory response Nature. 454: 455-462. PMID 18650916 DOI: 10.1038/Nature07203 |
0.442 |
|
| 2008 |
Mak BC, Wang Q, Laschinger C, Lee W, Ron D, Harding HP, Kaufman RJ, Scheuner D, Austin RC, McCulloch CA. Novel function of PERK as a mediator of force-induced apoptosis. The Journal of Biological Chemistry. 283: 23462-72. PMID 18550523 DOI: 10.1074/Jbc.M803194200 |
0.309 |
|
| 2008 |
Scheuner D, Kaufman RJ. The unfolded protein response: A pathway that links insulin demand with β-cell failure and diabetes Endocrine Reviews. 29: 317-333. PMID 18436705 DOI: 10.1210/Er.2007-0039 |
0.471 |
|
| 2008 |
Sakaki K, Wu J, Kaufman RJ. Protein kinase Ctheta is required for autophagy in response to stress in the endoplasmic reticulum. The Journal of Biological Chemistry. 283: 15370-80. PMID 18356160 DOI: 10.1074/Jbc.M710209200 |
0.53 |
|
| 2008 |
Thiaville MM, Pan YX, Gjymishka A, Zhong C, Kaufman RJ, Kilberg MS. MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells. The Journal of Biological Chemistry. 283: 10848-57. PMID 18287093 DOI: 10.1074/Jbc.M708320200 |
0.373 |
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| 2008 |
Zeenko VV, Wang C, Majumder M, Komar AA, Snider MD, Merrick WC, Kaufman RJ, Hatzoglou M. An efficient in vitro translation system from mammalian cells lacking the translational inhibition caused by eIF2 phosphorylation Rna. 14: 593-602. PMID 18230759 DOI: 10.1261/Rna.825008 |
0.396 |
|
| 2008 |
Callaghan MU, Kaufman RJ. Exploiting ER Stress to Eliminate Inhibitor Antibodies in Hemophilia Blood. 112: 3087-3087. DOI: 10.1182/Blood.V112.11.3087.3087 |
0.374 |
|
| 2008 |
Selvaraj SR, Kaufman RJ, Pipe SW. Incremental Improvement in Bioengineering of Coagulation Factor VIII for Efficient Expression: Elimination of a Dispensable Disulfide Loop Enhances Secretion Blood. 112: 3073-3073. DOI: 10.1182/Blood.V112.11.3073.3073 |
0.402 |
|
| 2007 |
Malhotra JD, Kaufman RJ. The endoplasmic reticulum and the unfolded protein response Seminars in Cell and Developmental Biology. 18: 716-731. PMID 18023214 DOI: 10.1016/J.Semcdb.2007.09.003 |
0.437 |
|
| 2007 |
Malhotra JD, Kaufman RJ. Endoplasmic reticulum stress and oxidative stress: A vicious cycle or a double-edged sword? Antioxidants and Redox Signaling. 9: 2277-2293. PMID 17979528 DOI: 10.1089/Ars.2007.1782 |
0.451 |
|
| 2007 |
Rutkowski DT, Kaufman RJ. That which does not kill me makes me stronger: adapting to chronic ER stress. Trends in Biochemical Sciences. 32: 469-76. PMID 17920280 DOI: 10.1016/J.Tibs.2007.09.003 |
0.759 |
|
| 2007 |
Wu J, Rutkowski DT, Dubois M, Swathirajan J, Saunders T, Wang J, Song B, Yau GD, Kaufman RJ. ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress. Developmental Cell. 13: 351-64. PMID 17765679 DOI: 10.1016/J.Devcel.2007.07.005 |
0.769 |
|
| 2007 |
Soldà T, Galli C, Kaufman RJ, Molinari M. Substrate-Specific Requirements for UGT1-Dependent Release from Calnexin Molecular Cell. 27: 238-249. PMID 17643373 DOI: 10.1016/J.Molcel.2007.05.032 |
0.326 |
|
| 2007 |
Drogat B, Auguste P, Nguyen DT, Bouchecareilh M, Pineau R, Nalbantoglu J, Kaufman RJ, Chevet E, Bikfalvi A, Moenner M. IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo. Cancer Research. 67: 6700-7. PMID 17638880 DOI: 10.1158/0008-5472.Can-06-3235 |
0.328 |
|
| 2007 |
Rutkowski DT, Kang SW, Goodman AG, Garrison JL, Taunton J, Katze MG, Kaufman RJ, Hegde RS. The role of p58IPK in protecting the stressed endoplasmic reticulum. Molecular Biology of the Cell. 18: 3681-91. PMID 17567950 DOI: 10.1091/Mbc.E07-03-0272 |
0.755 |
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| 2007 |
Renna M, Caporaso MG, Bonatti S, Kaufman RJ, Remondelli P. Regulation of ERGIC-53 gene transcription in response to endoplasmic reticulum stress Journal of Biological Chemistry. 282: 22499-22512. PMID 17535801 DOI: 10.1074/Jbc.M703778200 |
0.48 |
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| 2007 |
Mazroui R, Di Marco S, Kaufman RJ, Gallouzi IE. Inhibition of the ubiquitin-proteasome system induces stress granule formation. Molecular Biology of the Cell. 18: 2603-18. PMID 17475769 DOI: 10.1091/Mbc.E06-12-1079 |
0.42 |
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| 2007 |
Nagasawa K, Higashi T, Hosokawa N, Kaufman RJ, Nagata K. Simultaneous induction of the four subunits of the TRAP complex by ER stress accelerates ER degradation Embo Reports. 8: 483-489. PMID 17380188 DOI: 10.1038/Sj.Embor.7400933 |
0.394 |
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| 2007 |
Zhu A, Sun H, Raymond RM, Furie BC, Furie B, Bronstein M, Kaufman RJ, Westrick R, Ginsburg D. Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase. Blood. 109: 5270-5. PMID 17327402 DOI: 10.1182/Blood-2006-12-064188 |
0.309 |
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| 2007 |
Shang J, Gao N, Kaufman RJ, Ron D, Harding HP, Lehrman MA. Translation attenuation by PERK balances ER glycoprotein synthesis with lipid-linked oligosaccharide flux. The Journal of Cell Biology. 176: 605-16. PMID 17325203 DOI: 10.1083/Jcb.200607007 |
0.396 |
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| 2007 |
Vander Mierde D, Scheuner D, Quintens R, Patel R, Song B, Tsukamoto K, Beullens M, Kaufman RJ, Bollen M, Schuit FC. Glucose activates a protein phosphatase-1-mediated signaling pathway to enhance overall translation in pancreatic β-cells Endocrinology. 148: 609-617. PMID 17082262 DOI: 10.1210/En.2006-1012 |
0.36 |
|
| 2007 |
Kouroku Y, Fujita E, Tanida I, Ueno T, Isoai A, Kumagai H, Ogawa S, Kaufman RJ, Kominami E, Momoi T. ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation Cell Death and Differentiation. 14: 230-239. PMID 16794605 DOI: 10.1038/Sj.Cdd.4401984 |
0.441 |
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| 2006 |
Rutkowski DT, Arnold SM, Miller CN, Wu J, Li J, Gunnison KM, Mori K, Sadighi Akha AA, Raden D, Kaufman RJ. Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. Plos Biology. 4: e374. PMID 17090218 DOI: 10.1371/Journal.Pbio.0040374 |
0.781 |
|
| 2006 |
Nyfeler B, Zhang B, Ginsburg D, Kaufman RJ, Hauri HP. Cargo selectivity of the ERGIC-53/MCFD2 transport receptor complex. Traffic (Copenhagen, Denmark). 7: 1473-81. PMID 17010120 DOI: 10.1111/J.1600-0854.2006.00483.X |
0.365 |
|
| 2006 |
Zhou J, Liu CY, Back SH, Clark RL, Peisach D, Xu Z, Kaufman RJ. The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proceedings of the National Academy of Sciences of the United States of America. 103: 14343-8. PMID 16973740 DOI: 10.1073/Pnas.0606480103 |
0.388 |
|
| 2006 |
Denoyelle C, Abou-Rjaily G, Bezrookove V, Verhaegen M, Johnson TM, Fullen DR, Pointer JN, Gruber SB, Su LD, Nikiforov MA, Kaufman RJ, Bastian BC, Soengas MS. Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway. Nature Cell Biology. 8: 1053-63. PMID 16964246 DOI: 10.1038/Ncb1471 |
0.438 |
|
| 2006 |
Dang Y, Kedersha N, Low WK, Romo D, Gorospe M, Kaufman R, Anderson P, Liu JO. Eukaryotic initiation factor 2alpha-independent pathway of stress granule induction by the natural product pateamine A. The Journal of Biological Chemistry. 281: 32870-8. PMID 16951406 DOI: 10.1074/Jbc.M606149200 |
0.428 |
|
| 2006 |
Fribley AM, Evenchik B, Zeng Q, Park BK, Guan JY, Zhang H, Hale TJ, Soengas MS, Kaufman RJ, Wang CY. Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa. The Journal of Biological Chemistry. 281: 31440-7. PMID 16928686 DOI: 10.1074/Jbc.M604356200 |
0.387 |
|
| 2006 |
Mazroui R, Sukarieh R, Bordeleau ME, Kaufman RJ, Northcote P, Tanaka J, Gallouzi I, Pelletier J. Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2α phosphorylation Molecular Biology of the Cell. 17: 4212-4219. PMID 16870703 DOI: 10.1091/Mbc.E06-04-0318 |
0.422 |
|
| 2006 |
Scheuner D, Patel R, Wang F, Lee K, Kumar K, Wu J, Nilsson A, Karin M, Kaufman RJ. Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis. The Journal of Biological Chemistry. 281: 21458-68. PMID 16717090 DOI: 10.1074/Jbc.M603784200 |
0.465 |
|
| 2006 |
Back SH, Lee K, Vink E, Kaufman RJ. Cytoplasmic IRE1alpha-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stress. The Journal of Biological Chemistry. 281: 18691-706. PMID 16644724 DOI: 10.1074/Jbc.M602030200 |
0.407 |
|
| 2006 |
Zhang K, Kaufman RJ. Protein folding in the endoplasmic reticulum and the unfolded protein response Handbook of Experimental Pharmacology. 172: 69-91. PMID 16610355 DOI: 10.1007/3-540-29717-0_3 |
0.464 |
|
| 2006 |
Hu P, Han Z, Couvillon AD, Kaufman RJ, Exton JH. Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1α-mediated NF-κB activation and down-regulation of TRAF2 expression Molecular and Cellular Biology. 26: 3071-3084. PMID 16581782 DOI: 10.1128/Mcb.26.8.3071-3084.2006 |
0.429 |
|
| 2006 |
Schröder M, Kaufman RJ. Divergent roles of IRE1alpha and PERK in the unfolded protein response. Current Molecular Medicine. 6: 5-36. PMID 16472110 DOI: 10.2174/156652406775574569 |
0.465 |
|
| 2006 |
Zhang K, Shen X, Wu J, Sakaki K, Saunders T, Rutkowski DT, Back SH, Kaufman RJ. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell. 124: 587-99. PMID 16469704 DOI: 10.1016/J.Cell.2005.11.040 |
0.807 |
|
| 2006 |
Koritzinsky M, Magagnin MG, van den Beucken T, Seigneuric R, Savelkouls K, Dostie J, Pyronnet S, Kaufman RJ, Weppler SA, Voncken JW, Lambin P, Koumenis C, Sonenberg N, Wouters BG. Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. The Embo Journal. 25: 1114-25. PMID 16467844 DOI: 10.1038/Sj.Emboj.7600998 |
0.377 |
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| 2006 |
Oda Y, Okada T, Yoshida H, Kaufman RJ, Nagata K, Mori K. Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. The Journal of Cell Biology. 172: 383-93. PMID 16449189 DOI: 10.1083/Jcb.200507057 |
0.443 |
|
| 2006 |
Smith JA, Schmechel SC, Raghavan A, Abelson M, Reilly C, Katze MG, Kaufman RJ, Bohjanen PR, Schiff LA. Reovirus induces and benefits from an integrated cellular stress response. Journal of Virology. 80: 2019-33. PMID 16439558 DOI: 10.1128/Jvi.80.4.2019-2033.2006 |
0.417 |
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| 2006 |
Zhang K, Kaufman RJ. The unfolded protein response: A stress signaling pathway critical for health and disease Neurology. 66. PMID 16432136 DOI: 10.1212/01.Wnl.0000192306.98198.Ec |
0.484 |
|
| 2006 |
Wu J, Kaufman RJ. From acute ER stress to physiological roles of the unfolded protein response Cell Death and Differentiation. 13: 374-384. PMID 16397578 DOI: 10.1038/Sj.Cdd.4401840 |
0.553 |
|
| 2006 |
Malhotra JD, Zhang K, Miao H, Pipe SW, Kaufman RJ. Antioxidants Improve Factor VIII Secretion in the Liver by Preventing Oxidative Stress, Activation of the Unfolded Protein Response, and Apoptosis. Blood. 108: 197-197. DOI: 10.1182/Blood.V108.11.197.197 |
0.451 |
|
| 2006 |
Russell J, Dargaud Y, Kaufman RJ, Negrier C, Pipe SW. Inactivation-Resistant Recombinant Factor VIII Exhibits Superior Thrombin Generation Capacity in Comparison to Wild-Type and B Domain-Deleted Factor VIII. Blood. 108: 1604-1604. DOI: 10.1182/Blood.V108.11.1604.1604 |
0.349 |
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| 2005 |
Harding HP, Zhang Y, Khersonsky S, Marciniak S, Scheuner D, Kaufman RJ, Javitt N, Chang YT, Ron D. Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression. Cell Metabolism. 2: 361-71. PMID 16330322 DOI: 10.1016/J.Cmet.2005.11.005 |
0.468 |
|
| 2005 |
Molinari M, Galli C, Vanoni O, Arnold SM, Kaufman RJ. Persistent glycoprotein misfolding activates the glucosidase II/UGT1-driven calnexin cycle to delay aggregation and loss of folding competence Molecular Cell. 20: 503-512. PMID 16307915 DOI: 10.1016/J.Molcel.2005.09.027 |
0.326 |
|
| 2005 |
Shen X, Ellis RE, Sakaki K, Kaufman RJ. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Plos Genetics. 1: e37. PMID 16184190 DOI: 10.1371/Journal.Pgen.0010037 |
0.655 |
|
| 2005 |
Bi M, Naczki C, Koritzinsky M, Fels D, Blais J, Hu N, Harding H, Novoa I, Varia M, Raleigh J, Scheuner D, Kaufman RJ, Bell J, Ron D, Wouters BG, et al. ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. The Embo Journal. 24: 3470-81. PMID 16148948 DOI: 10.1038/Sj.Emboj.7600777 |
0.393 |
|
| 2005 |
Scheuner D, Mierde DV, Song B, Flamez D, Creemers JWM, Tsukamoto K, Ribick M, Schuit FC, Kaufman RJ. Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis Nature Medicine. 11: 757-764. PMID 15980866 DOI: 10.1038/Nm1259 |
0.341 |
|
| 2005 |
Kedersha N, Stoecklin G, Ayodele M, Yacono P, Lykke-Andersen J, Fritzler MJ, Scheuner D, Kaufman RJ, Golan DE, Anderson P. Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. The Journal of Cell Biology. 169: 871-84. PMID 15967811 DOI: 10.1083/Jcb.200502088 |
0.405 |
|
| 2005 |
Schröder M, Kaufman RJ. The mammalian unfolded protein response. Annual Review of Biochemistry. 74: 739-89. PMID 15952902 DOI: 10.1146/Annurev.Biochem.73.011303.074134 |
0.428 |
|
| 2005 |
McInerney GM, Kedersha NL, Kaufman RJ, Anderson P, Liljeström P. Importance of eIF2α phosphorylation and stress granule assembly in alphavirus translation regulation Molecular Biology of the Cell. 16: 3753-3763. PMID 15930128 DOI: 10.1091/Mbc.E05-02-0124 |
0.416 |
|
| 2005 |
Zhang B, Kaufman RJ, Ginsburg D. LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor VIII in the early secretory pathway Journal of Biological Chemistry. 280: 25881-25886. PMID 15886209 DOI: 10.1074/Jbc.M502160200 |
0.332 |
|
| 2005 |
Back SH, Schröder M, Lee K, Zhang K, Kaufman RJ. ER stress signaling by regulated splicing: IRE1/HAC1/XBP1. Methods (San Diego, Calif.). 35: 395-416. PMID 15804613 DOI: 10.1016/J.Ymeth.2005.03.001 |
0.482 |
|
| 2005 |
Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science (New York, N.Y.). 307: 935-9. PMID 15705855 DOI: 10.1126/Science.1101902 |
0.413 |
|
| 2005 |
Fernandez J, Yaman I, Huang C, Liu H, Lopez AB, Komar AA, Caprara MG, Merrick WC, Snider MD, Kaufman RJ, Lamers WH, Hatzoglou M. Ribosome stalling regulates ires-mediated translation in eukaryotes, a parallel to prokaryotic attenuation Molecular Cell. 17: 405-416. PMID 15694341 DOI: 10.1016/J.Molcel.2004.12.024 |
0.368 |
|
| 2005 |
Zhang K, Wong HN, Song B, Miller CN, Scheuner D, Kaufman RJ. The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis. The Journal of Clinical Investigation. 115: 268-81. PMID 15690081 DOI: 10.1172/Jci21848 |
0.421 |
|
| 2005 |
McEwen E, Kedersha N, Song B, Scheuner D, Gilks N, Han A, Chen JJ, Anderson P, Kaufman RJ. Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure Journal of Biological Chemistry. 280: 16925-16933. PMID 15684421 DOI: 10.1074/Jbc.M412882200 |
0.432 |
|
| 2005 |
Schröder M, Kaufman RJ. ER stress and the unfolded protein response. Mutation Research. 569: 29-63. PMID 15603751 DOI: 10.1016/J.Mrfmmm.2004.06.056 |
0.461 |
|
| 2005 |
Zhang B, McGee B, Nichols WC, Guglielmone H, Downes K, Peyvandi F, de Bosch NB, Ruiz-Saez A, Chatelain B, Olpinski M, Bockenstedt P, Sperl W, Kaufman RJ, Ginsburg D. Mutations in LMAN1 and MCFD2 May Account for All Cases of Combined Deficiency of Factor V and Factor VIII. Blood. 106: 724-724. DOI: 10.1182/Blood.V106.11.724.724 |
0.345 |
|
| 2004 |
Yamamoto K, Yoshida H, Kokame K, Kaufman RJ, Mori K. Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II. Journal of Biochemistry. 136: 343-50. PMID 15598891 DOI: 10.1093/Jb/Mvh122 |
0.476 |
|
| 2004 |
Deng J, Lu PD, Zhang Y, Scheuner D, Kaufman RJ, Sonenberg N, Harding HP, Ron D. Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Molecular and Cellular Biology. 24: 10161-8. PMID 15542827 DOI: 10.1128/Mcb.24.23.10161-10168.2004 |
0.425 |
|
| 2004 |
Shen X, Zhang K, Kaufman RJ. The unfolded protein response--a stress signaling pathway of the endoplasmic reticulum. Journal of Chemical Neuroanatomy. 28: 79-92. PMID 15363493 DOI: 10.1016/J.Jchemneu.2004.02.006 |
0.636 |
|
| 2004 |
Ye P, Thompson AR, Sarkar R, Shen Z, Lillicrap DP, Kaufman RJ, Ochs HD, Rawlings DJ, Miao CH. Naked DNA transfer of Factor VIII induced transgene-specific, species-independent immune response in hemophilia A mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 10: 117-26. PMID 15233948 DOI: 10.1016/J.Ymthe.2004.04.009 |
0.3 |
|
| 2004 |
Nguyên DT, Kebache S, Fazel A, Wong HN, Jenna S, Emadali A, Lee EH, Bergeron JJ, Kaufman RJ, Larose L, Chevet E. Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress. Molecular Biology of the Cell. 15: 4248-60. PMID 15201339 DOI: 10.1091/Mbc.E03-11-0851 |
0.476 |
|
| 2004 |
Wu S, Tan M, Hu Y, Wang JL, Scheuner D, Kaufman RJ. Ultraviolet light activates NFkappaB through translational inhibition of IkappaBalpha synthesis. The Journal of Biological Chemistry. 279: 34898-902. PMID 15184376 DOI: 10.1074/Jbc.M405616200 |
0.371 |
|
| 2004 |
Schröder M, Clark R, Liu CY, Kaufman RJ. The unfolded protein response represses differentiation through the RPD3-SIN3 histone deacetylase. The Embo Journal. 23: 2281-92. PMID 15141165 DOI: 10.1038/Sj.Emboj.7600233 |
0.394 |
|
| 2004 |
Zhang K, Kaufman RJ. Signaling the unfolded protein response from the endoplasmic reticulum Journal of Biological Chemistry. 279: 25935-25938. PMID 15070890 DOI: 10.1074/Jbc.R400008200 |
0.37 |
|
| 2004 |
Hsu LC, Park JM, Zhang K, Luo JL, Maeda S, Kaufman RJ, Eckmann L, Guiney DG, Karin M. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature. 428: 341-5. PMID 15029200 DOI: 10.1038/Nature02405 |
0.341 |
|
| 2004 |
Kaufman RJ. Regulation of mRNA translation by protein folding in the endoplasmic reticulum Trends in Biochemical Sciences. 29: 152-158. PMID 15003273 DOI: 10.1016/J.Tibs.2004.01.004 |
0.432 |
|
| 2004 |
Tardif KD, Mori K, Kaufman RJ, Siddiqui A. Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response. The Journal of Biological Chemistry. 279: 17158-64. PMID 14960590 DOI: 10.1074/Jbc.M312144200 |
0.427 |
|
| 2004 |
Rutkowski DT, Kaufman RJ. A trip to the ER: coping with stress. Trends in Cell Biology. 14: 20-8. PMID 14729177 DOI: 10.1016/J.Tcb.2003.11.001 |
0.756 |
|
| 2004 |
Miao HZ, Sirachainan N, Palmer L, Kucab P, Cunningham MA, Kaufman RJ, Pipe SW. Bioengineering of coagulation factor VIII for improved secretion Blood. 103: 3412-3419. PMID 14726380 DOI: 10.1182/Blood-2003-10-3591 |
0.372 |
|
| 2004 |
Lu PD, Jousse C, Marciniak SJ, Zhang Y, Novoa I, Scheuner D, Kaufman RJ, Ron D, Harding HP. Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2. The Embo Journal. 23: 169-79. PMID 14713949 DOI: 10.1038/Sj.Emboj.7600030 |
0.459 |
|
| 2003 |
Scheuner D, Gromeier M, Davies MV, Dorner AJ, Song B, Patel RV, Wimmer EJ, McLendon RE, Kaufman RJ. The double-stranded RNA-activated protein kinase mediates viral-induced encephalitis. Virology. 317: 263-74. PMID 14698665 DOI: 10.1016/J.Virol.2003.08.010 |
0.307 |
|
| 2003 |
Aparna G, Bhuyan AK, Sahdev S, Hasnain SE, Kaufman RJ, Ramaiah KV. Stress-induced apoptosis in Spodoptera frugiperda (Sf9) cells: baculovirus p35 mitigates eIF2 alpha phosphorylation. Biochemistry. 42: 15352-60. PMID 14690445 DOI: 10.1021/Bi0349423 |
0.359 |
|
| 2003 |
Cunningham MA, Pipe SW, Zhang B, Hauri HP, Ginsburg D, Kaufman RJ. LMAN1 is a molecular chaperone for the secretion of coagulation factor VIII. Journal of Thrombosis and Haemostasis : Jth. 1: 2360-7. PMID 14629470 DOI: 10.1046/J.1538-7836.2003.00415.X |
0.341 |
|
| 2003 |
Cullinan SB, Zhang D, Hannink M, Arvisais E, Kaufman RJ, Diehl JA. Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Molecular and Cellular Biology. 23: 7198-209. PMID 14517290 DOI: 10.1128/Mcb.23.20.7198-7209.2003 |
0.457 |
|
| 2003 |
Arnold SM, Kaufman RJ. The Noncatalytic Portion of Human UDP-glucose:Glycoprotein Glucosyltransferase I Confers UDP-glucose Binding and Transferase Function to the Catalytic Domain Journal of Biological Chemistry. 278: 43320-43328. PMID 12913004 DOI: 10.1074/Jbc.M305800200 |
0.353 |
|
| 2003 |
Jiang HY, Wek SA, McGrath BC, Scheuner D, Kaufman RJ, Cavener DR, Wek RC. Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses. Molecular and Cellular Biology. 23: 5651-63. PMID 12897138 DOI: 10.1128/Mcb.23.16.5651-5663.2003 |
0.417 |
|
| 2003 |
Schröder M, Clark R, Kaufman RJ. IRE1- and HAC1-independent transcriptional regulation in the unfolded protein response of yeast. Molecular Microbiology. 49: 591-606. PMID 12864846 DOI: 10.1046/J.1365-2958.2003.03585.X |
0.504 |
|
| 2003 |
Yaman I, Fernandez J, Liu H, Caprara M, Komar AA, Koromilas AE, Zhou L, Snider MD, Scheuner D, Kaufman RJ, Hatzoglou M. The zipper model of translational control: a small upstream ORF is the switch that controls structural remodeling of an mRNA leader. Cell. 113: 519-31. PMID 12757712 DOI: 10.1016/S0092-8674(03)00345-3 |
0.357 |
|
| 2003 |
Hossain GS, van Thienen JV, Werstuck GH, Zhou J, Sood SK, Dickhout JG, de Koning AB, Tang D, Wu D, Falk E, Poddar R, Jacobsen DW, Zhang K, Kaufman RJ, Austin RC. TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia. The Journal of Biological Chemistry. 278: 30317-27. PMID 12738777 DOI: 10.1074/Jbc.M212897200 |
0.427 |
|
| 2003 |
Knee R, Ahsan I, Mesaeli N, Kaufman RJ, Michalak M. Compromised calnexin function in calreticulin-deficient cells. Biochemical and Biophysical Research Communications. 304: 661-6. PMID 12727205 DOI: 10.1016/S0006-291X(03)00643-0 |
0.418 |
|
| 2003 |
Zhang B, Cunningham MA, Nichols WC, Bernat JA, Seligsohn U, Pipe SW, McVey JH, Schulte-Overberg U, de Bosch NB, Ruiz-Saez A, White GC, Tuddenham EG, Kaufman RJ, Ginsburg D. Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex. Nature Genetics. 34: 220-5. PMID 12717434 DOI: 10.1038/Ng1153 |
0.381 |
|
| 2003 |
Liu CY, Kaufman RJ. The unfolded protein response. Journal of Cell Science. 116: 1861-2. PMID 12692187 DOI: 10.1242/Jcs.00408 |
0.476 |
|
| 2003 |
Rutkowski DT, Kaufman RJ. All roads lead to ATF4. Developmental Cell. 4: 442-4. PMID 12689582 DOI: 10.1016/S1534-5807(03)00100-X |
0.731 |
|
| 2003 |
Reddy RK, Mao C, Baumeister P, Austin RC, Kaufman RJ, Lee AS. Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors: role of ATP binding site in suppression of caspase-7 activation. The Journal of Biological Chemistry. 278: 20915-24. PMID 12665508 DOI: 10.1074/Jbc.M212328200 |
0.433 |
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| 2003 |
Ward SL, Scheuner D, Poppers J, Kaufman RJ, Mohr I, Leib DA. In vivo replication of an ICP34.5 second-site suppressor mutant following corneal infection correlates with in vitro regulation of eIF2 alpha phosphorylation. Journal of Virology. 77: 4626-34. PMID 12663769 DOI: 10.1128/Jvi.77.8.4626-4634.2003 |
0.312 |
|
| 2003 |
Liu CY, Xu Z, Kaufman RJ. Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha. The Journal of Biological Chemistry. 278: 17680-7. PMID 12637535 DOI: 10.1074/Jbc.M300418200 |
0.338 |
|
| 2003 |
Yoshida H, Matsui T, Hosokawa N, Kaufman RJ, Nagata K, Mori K. A time-dependent phase shift in the mammalian unfolded protein response. Developmental Cell. 4: 265-71. PMID 12586069 DOI: 10.1016/S1534-5807(03)00022-4 |
0.453 |
|
| 2003 |
Lee K, Neigeborn L, Kaufman RJ. The unfolded protein response is required for haploid tolerance in yeast. The Journal of Biological Chemistry. 278: 11818-27. PMID 12560331 DOI: 10.1074/Jbc.M210475200 |
0.428 |
|
| 2003 |
Stacey Arnold M, Kaufman RJ. Protein synthesis, folding, modification, and secretion in mammalian cells New Comprehensive Biochemistry. 38: 411-432. DOI: 10.1016/S0167-7306(03)38025-1 |
0.415 |
|
| 2002 |
Kingston RE, Kaufman RJ, Bebbington CR, Rolfe MR. Amplification using CHO cell expression vectors. Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.]. Unit 16.23. PMID 18265304 DOI: 10.1002/0471142727.Mb1623S60 |
0.534 |
|
| 2002 |
Kaufman RJ. Orchestrating the unfolded protein response in health and disease. The Journal of Clinical Investigation. 110: 1389-98. PMID 12438434 DOI: 10.1172/Jci16886 |
0.472 |
|
| 2002 |
Deng J, Harding HP, Raught B, Gingras AC, Berlanga JJ, Scheuner D, Kaufman RJ, Ron D, Sonenberg N. Activation of GCN2 in UV-irradiated cells inhibits translation. Current Biology : Cb. 12: 1279-86. PMID 12176355 DOI: 10.1016/S0960-9822(02)01037-0 |
0.404 |
|
| 2002 |
Kaufman RJ, Scheuner D, Schröder M, Shen X, Lee K, Liu CY, Arnold SM. The unfolded protein response in nutrient sensing and differentiation. Nature Reviews. Molecular Cell Biology. 3: 411-21. PMID 12042763 DOI: 10.1038/Nrm829 |
0.619 |
|
| 2002 |
Liu CY, Wong HN, Schauerte JA, Kaufman RJ. The protein kinase/endoribonuclease IRE1alpha that signals the unfolded protein response has a luminal N-terminal ligand-independent dimerization domain. The Journal of Biological Chemistry. 277: 18346-56. PMID 11897784 DOI: 10.1074/Jbc.M112454200 |
0.422 |
|
| 2002 |
Wu S, Hu Y, Wang JL, Chatterjee M, Shi Y, Kaufman RJ. Ultraviolet light inhibits translation through activation of the unfolded protein response kinase PERK in the lumen of the endoplasmic reticulum. The Journal of Biological Chemistry. 277: 18077-83. PMID 11877419 DOI: 10.1074/Jbc.M110164200 |
0.421 |
|
| 2002 |
Lee K, Tirasophon W, Shen X, Michalak M, Prywes R, Okada T, Yoshida H, Mori K, Kaufman RJ. IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes & Development. 16: 452-66. PMID 11850408 DOI: 10.1101/Gad.964702 |
0.653 |
|
| 2002 |
Tallóczy Z, Jiang W, Virgin HW, Leib DA, Scheuner D, Kaufman RJ, Eskelinen EL, Levine B. Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway. Proceedings of the National Academy of Sciences of the United States of America. 99: 190-5. PMID 11756670 DOI: 10.1073/Pnas.012485299 |
0.368 |
|
| 2001 |
Shen X, Ellis RE, Lee K, Liu CY, Yang K, Solomon A, Yoshida H, Morimoto R, Kurnit DM, Mori K, Kaufman RJ. Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell. 107: 893-903. PMID 11779465 DOI: 10.1016/S0092-8674(01)00612-2 |
0.642 |
|
| 2001 |
Zhang C, Cai Y, Adachi MT, Oshiro S, Aso T, Kaufman RJ, Kitajima S. Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response. The Journal of Biological Chemistry. 276: 35867-74. PMID 11447214 DOI: 10.1074/Jbc.M100747200 |
0.321 |
|
| 2001 |
Scheuner D, Song B, McEwen E, Liu C, Laybutt R, Gillespie P, Saunders T, Bonner-Weir S, Kaufman RJ. Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Molecular Cell. 7: 1165-76. PMID 11430820 DOI: 10.1016/S1097-2765(01)00265-9 |
0.47 |
|
| 2000 |
Kaufman RJ. Overview of vector design for mammalian gene expression. Molecular Biotechnology. 16: 151-60. PMID 11131974 DOI: 10.1385/Mb:16:2:151 |
0.372 |
|
| 2000 |
Schröder M, Chang JS, Kaufman RJ. The unfolded protein response represses nitrogen-starvation induced developmental differentiation in yeast. Genes & Development. 14: 2962-75. PMID 11114886 DOI: 10.1101/Gad.852300 |
0.452 |
|
| 2000 |
Tirasophon W, Lee K, Callaghan B, Welihinda A, Kaufman RJ. The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response Genes and Development. 14: 2725-2736. PMID 11069889 DOI: 10.1101/Gad.839400 |
0.458 |
|
| 2000 |
Sudhakar A, Ramachandran A, Ghosh S, Hasnain SE, Kaufman RJ, Ramaiah KV. Phosphorylation of serine 51 in initiation factor 2 alpha (eIF2 alpha) promotes complex formation between eIF2 alpha(P) and eIF2B and causes inhibition in the guanine nucleotide exchange activity of eIF2B. Biochemistry. 39: 12929-38. PMID 11041858 DOI: 10.1021/Bi0008682 |
0.354 |
|
| 2000 |
Maggi LB, Heitmeier MR, Scheuner D, Kaufman RJ, Buller RM, Corbett JA. Potential role of PKR in double-stranded RNA-induced macrophage activation. The Embo Journal. 19: 3630-8. PMID 10899117 DOI: 10.1093/Emboj/19.14.3630 |
0.321 |
|
| 2000 |
Wang Y, Shen J, Arenzana N, Tirasophon W, Kaufman RJ, Prywes R. Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response. The Journal of Biological Chemistry. 275: 27013-20. PMID 10856300 DOI: 10.1074/Jbc.M003322200 |
0.457 |
|
| 2000 |
Liu CY, Schröder M, Kaufman RJ. Ligand-independent dimerization activates the stress response kinases IRE1 and PERK in the lumen of the endoplasmic reticulum. The Journal of Biological Chemistry. 275: 24881-5. PMID 10835430 DOI: 10.1074/Jbc.M004454200 |
0.478 |
|
| 2000 |
Arnold SM, Fessler LI, Fessler JH, Kaufman RJ. Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity. Biochemistry. 39: 2149-63. PMID 10694380 DOI: 10.1021/Bi9916473 |
0.419 |
|
| 2000 |
Tagliavacca L, Wang Q, Kaufman RJ. ATP-dependent dissociation of non-disulfide-linked aggregates of coagulation factor VIII is a rate-limiting step for secretion. Biochemistry. 39: 1973-81. PMID 10684647 DOI: 10.1021/Bi991896R |
0.327 |
|
| 2000 |
Welihinda AA, Tirasophon W, Kaufman RJ. The transcriptional co-activator ADA5 is required for HAC1 mRNA processing in vivo. The Journal of Biological Chemistry. 275: 3377-81. PMID 10652329 DOI: 10.1074/Jbc.275.5.3377 |
0.448 |
|
| 1999 |
Niwa M, Sidrauski C, Kaufman RJ, Walter P. A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response. Cell. 99: 691-702. PMID 10619423 DOI: 10.1016/S0092-8674(00)81667-0 |
0.463 |
|
| 1999 |
Moussalli M, Pipe SW, Hauri HP, Nichols WC, Ginsburg D, Kaufman RJ. Mannose-dependent endoplasmic reticulum (ER)-Golgi intermediate compartment-53-mediated ER to Golgi trafficking of coagulation factors V and VIII. The Journal of Biological Chemistry. 274: 32539-42. PMID 10551804 DOI: 10.1074/Jbc.274.46.32539 |
0.384 |
|
| 1999 |
Foti DM, Welihinda A, Kaufman RJ, Lee AS. Conservation and divergence of the yeast and mammalian unfolded protein response. Activation of specific mammalian endoplasmic reticulum stress element of the grp78/BiP promoter by yeast Hac1. The Journal of Biological Chemistry. 274: 30402-9. PMID 10521417 DOI: 10.1074/jbc.274.43.30402 |
0.388 |
|
| 1999 |
Kaufman RJ. Double-stranded RNA-activated protein kinase mediates virus-induced apoptosis: a new role for an old actor. Proceedings of the National Academy of Sciences of the United States of America. 96: 11693-5. PMID 10518510 DOI: 10.1073/Pnas.96.21.11693 |
0.335 |
|
| 1999 |
Kaufman RJ. Advances toward gene therapy for hemophilia at the millennium. Human Gene Therapy. 10: 2091-107. PMID 10498242 DOI: 10.1089/10430349950017095 |
0.341 |
|
| 1999 |
Kaufman RJ. Correction of genetic disease by making sense from nonsense. The Journal of Clinical Investigation. 104: 367-8. PMID 10449426 DOI: 10.1172/Jci8055 |
0.339 |
|
| 1999 |
Welihinda AA, Tirasophon W, Kaufman RJ. The cellular response to protein misfolding in the endoplasmic reticulum. Gene Expression. 7: 293-300. PMID 10440230 |
0.439 |
|
| 1999 |
Kaufman RJ. Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes & Development. 13: 1211-33. PMID 10346810 DOI: 10.1101/Gad.13.10.1211 |
0.494 |
|
| 1999 |
Thorelli E, Kaufman RJ, Dahlbäck B. Cleavage of factor V at Arg 506 by activated protein C and the expression of anticoagulant activity of factor V. Blood. 93: 2552-8. PMID 10194434 DOI: 10.1182/Blood.V93.8.2552 |
0.33 |
|
| 1999 |
Connelly S, Andrews JL, Gallo-Penn AM, Tagliavacca L, Kaufman RJ, Kaleko M. Evaluation of an adenoviral vector encoding full-length human factor VIII in hemophiliac mice Thrombosis and Haemostasis. 81: 234-239. PMID 10063998 DOI: 10.1055/S-0037-1614449 |
0.335 |
|
| 1999 |
Kumar KU, Srivastava SP, Kaufman RJ. Double-stranded RNA-activated protein kinase (PKR) is negatively regulated by 60S ribosomal subunit protein L18. Molecular and Cellular Biology. 19: 1116-25. PMID 9891046 DOI: 10.1128/Mcb.19.2.1116 |
0.362 |
|
| 1999 |
Kaufman RJ, Dorner AJ, Fass DN. von Willebrand Factor Elevates Plasma Factor VIII Without Induction of Factor VIII Messenger RNA in the Liver Blood. 93: 193-197. DOI: 10.1182/Blood.V93.1.193.401K43_193_197 |
0.311 |
|
| 1999 |
Pipe S, Kaufman R. Regulation of Factor VIII Expression and Activity by von Willebrand Factor Thrombosis and Haemostasis. 82: 201-208. DOI: 10.1055/S-0037-1615834 |
0.332 |
|
| 1998 |
Wu S, Kumar KU, Kaufman RJ. Identification and requirement of three ribosome binding domains in dsRNA-dependent protein kinase (PKR). Biochemistry. 37: 13816-26. PMID 9753471 DOI: 10.1021/Bi981472H |
0.322 |
|
| 1998 |
Kaufman RJ. Post-translational modifications required for coagulation factor secretion and function. Thrombosis and Haemostasis. 79: 1068-79. PMID 9657426 DOI: 10.1055/S-0037-1615018 |
0.418 |
|
| 1998 |
Tirasophon W, Welihinda AA, Kaufman RJ. A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells. Genes & Development. 12: 1812-24. PMID 9637683 DOI: 10.1101/Gad.12.12.1812 |
0.504 |
|
| 1998 |
Yang TL, Cui J, Rehumtulla A, Yang A, Moussalli M, Kaufman RJ, Ginsburg D. The structure and function of murine factor V and its inactivation by protein C. Blood. 91: 4593-9. PMID 9616155 DOI: 10.1182/Blood.V91.12.4593.412A02_4593_4599 |
0.308 |
|
| 1998 |
Nichols WC, Seligsohn U, Zivelin A, Terry VH, Hertel CE, Wheatley MA, Moussalli MJ, Hauri HP, Ciavarella N, Kaufman RJ, Ginsburg D. Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII. Cell. 93: 61-70. PMID 9546392 DOI: 10.1016/S0092-8674(00)81146-0 |
0.358 |
|
| 1998 |
Welihinda AA, Tirasophon W, Green SR, Kaufman RJ. Protein serine/threonine phosphatase Ptc2p negatively regulates the unfolded-protein response by dephosphorylating Ire1p kinase. Molecular and Cellular Biology. 18: 1967-77. PMID 9528768 DOI: 10.1128/Mcb.18.4.1967 |
0.471 |
|
| 1998 |
Pipe SW, Morris JA, Shah J, Kaufman RJ. Differential interaction of coagulation factor VIII and factor V with protein chaperones calnexin and calreticulin. The Journal of Biological Chemistry. 273: 8537-44. PMID 9525969 DOI: 10.1074/Jbc.273.14.8537 |
0.354 |
|
| 1998 |
Srivastava SP, Kumar KU, Kaufman RJ. Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase. The Journal of Biological Chemistry. 273: 2416-23. PMID 9442091 DOI: 10.1074/Jbc.273.4.2416 |
0.367 |
|
| 1998 |
Amano K, Sarkar R, Pemberton S, Kemball-Cook G, Kazazian HH, Kaufman RJ. The molecular basis for cross-reacting material-positive hemophilia A due to missense mutations within the A2-domain of factor VIII. Blood. 91: 538-48. PMID 9427707 DOI: 10.1182/Blood.V91.2.538 |
0.332 |
|
| 1998 |
Amano K, Michnick D, Moussalli M, Kaufman R. Mutation at either Arg336 or Arg562 in Factor VIII Is Insufficient for Complete Resistance to Activated Protein C (APC)-mediated Inactivation: Implications for the APC Resistance Test Thrombosis and Haemostasis. 79: 557-563. DOI: 10.1055/S-0037-1614944 |
0.313 |
|
| 1997 |
Thorelli E, Kaufman RJ, Dahlbäck B. Cleavage requirements for activation of factor V by factor Xa. European Journal of Biochemistry. 247: 12-20. PMID 9249003 DOI: 10.1111/J.1432-1033.1997.00012.X |
0.307 |
|
| 1997 |
Kaufman RJ. DNA transfection to study translational control in mammalian cells. Methods (San Diego, Calif.). 11: 361-70. PMID 9126551 DOI: 10.1006/Meth.1996.0434 |
0.37 |
|
| 1997 |
Welihinda AA, Tirasophon W, Green SR, Kaufman RJ. Gene induction in response to unfolded protein in the endoplasmic reticulum is mediated through Ire1p kinase interaction with a transcriptional coactivator complex containing Ada5p. Proceedings of the National Academy of Sciences of the United States of America. 94: 4289-94. PMID 9113982 DOI: 10.1073/Pnas.94.9.4289 |
0.428 |
|
| 1997 |
Morris JA, Dorner AJ, Edwards CA, Hendershot LM, Kaufman RJ. Immunoglobulin binding protein (BiP) function is required to protect cells from endoplasmic reticulum stress but is not required for the secretion of selective proteins. The Journal of Biological Chemistry. 272: 4327-34. PMID 9020152 DOI: 10.1074/Jbc.272.7.4327 |
0.49 |
|
| 1997 |
Wu S, Kaufman RJ. A model for the double-stranded RNA (dsRNA)-dependent dimerization and activation of the dsRNA-activated protein kinase PKR. The Journal of Biological Chemistry. 272: 1291-6. PMID 8995434 DOI: 10.1074/Jbc.272.2.1291 |
0.309 |
|
| 1996 |
Israel DI, Nove J, Kerns KM, Kaufman RJ, Rosen V, Cox KA, Wozney JM. Heterodimeric bone morphogenetic proteins show enhanced activity in vitro and in vivo. Growth Factors (Chur, Switzerland). 13: 291-300. PMID 8919035 DOI: 10.3109/08977199609003229 |
0.315 |
|
| 1996 |
Mohlke KL, Nichols WC, Rehemtulla A, Kaufman RJ, Fagerström HM, Ritvanen KLA, Kekomäki R, Ginsburg D. A common frameshift mutation in von Willebrand factor does not alter mRNA stability but interferes with normal propeptide processing British Journal of Haematology. 95: 184-191. PMID 8857958 DOI: 10.1046/J.1365-2141.1996.7572377.X |
0.319 |
|
| 1996 |
Pipe SW, Kaufman RJ. Factor VIII C2 domain missense mutations exhibit defective trafficking of biologically functional proteins. The Journal of Biological Chemistry. 271: 25671-6. PMID 8810344 DOI: 10.1074/Jbc.271.41.25671 |
0.348 |
|
| 1996 |
Brostrom CO, Prostko CR, Kaufman RJ, Brostrom MA. Inhibition of translational initiation by activators of the glucose-regulated stress protein and heat shock protein stress response systems. Role of the interferon-inducible double-stranded RNA-activated eukaryotic initiation factor 2alpha kinase. The Journal of Biological Chemistry. 271: 24995-5002. PMID 8798781 DOI: 10.1074/Jbc.271.40.24995 |
0.43 |
|
| 1996 |
Wu S, Rehemtulla A, Gupta NK, Kaufman RJ. A eukaryotic translation initiation factor 2-associated 67 kDa glycoprotein partially reverses protein synthesis inhibition by activated double-stranded RNA-dependent protein kinase in intact cells. Biochemistry. 35: 8275-80. PMID 8679583 DOI: 10.1021/Bi953028+ |
0.361 |
|
| 1996 |
Welihinda AA, Kaufman RJ. The unfolded protein response pathway in Saccharomyces cerevisiae. Oligomerization and trans-phosphorylation of Ire1p (Ern1p) are required for kinase activation. The Journal of Biological Chemistry. 271: 18181-7. PMID 8663458 DOI: 10.1074/Jbc.271.30.18181 |
0.403 |
|
| 1996 |
Wu S, Kaufman RJ. Double-stranded (ds) RNA binding and not dimerization correlates with the activation of the dsRNA-dependent protein kinase (PKR). The Journal of Biological Chemistry. 271: 1756-63. PMID 8576179 DOI: 10.1074/Jbc.271.3.1756 |
0.353 |
|
| 1995 |
Srivastava SP, Davies MV, Kaufman RJ. Calcium depletion from the endoplasmic reticulum activates the double-stranded RNA-dependent protein kinase (PKR) to inhibit protein synthesis. The Journal of Biological Chemistry. 270: 16619-24. PMID 7622470 DOI: 10.1074/Jbc.270.28.16619 |
0.346 |
|
| 1995 |
Drews R, Paleyanda RK, Lee TK, Chang RR, Rehemtulla A, Kaufman RJ, Drohan WN, Luboń H. Proteolytic maturation of protein C upon engineering the mouse mammary gland to express furin. Proceedings of the National Academy of Sciences of the United States of America. 92: 10462-6. PMID 7479820 DOI: 10.1073/Pnas.92.23.10462 |
0.339 |
|
| 1994 |
Pittman DD, Tomkinson KN, Michnick D, Selighsohn U, Kaufman RJ. Posttranslational sulfation of factor V is required for efficient thrombin cleavage and activation and for full procoagulant activity. Biochemistry. 33: 6952-9. PMID 8204629 DOI: 10.1021/Bi00188A026 |
0.314 |
|
| 1994 |
Ramaiah KV, Davies MV, Chen JJ, Kaufman RJ. Expression of mutant eukaryotic initiation factor 2 alpha subunit (eIF-2 alpha) reduces inhibition of guanine nucleotide exchange activity of eIF-2B mediated by eIF-2 alpha phosphorylation. Molecular and Cellular Biology. 14: 4546-53. PMID 8007958 DOI: 10.1128/Mcb.14.7.4546 |
0.31 |
|
| 1994 |
Pittman DD, Marquette KA, Kaufman RJ. Role of the B domain for factor VIII and factor V expression and function. Blood. 84: 4214-25. PMID 7994036 DOI: 10.1182/Blood.V84.12.4214.Bloodjournal84124214 |
0.303 |
|
| 1994 |
Dorner AJ, Kaufman RJ. The levels of endoplasmic reticulum proteins and ATP affect folding and secretion of selective proteins. Biologicals : Journal of the International Association of Biological Standardization. 22: 103-12. PMID 7917226 DOI: 10.1006/Biol.1994.1016 |
0.414 |
|
| 1994 |
Kaufman RJ. Control of gene expression at the level of translation initiation. Current Opinion in Biotechnology. 5: 550-7. PMID 7765472 DOI: 10.1016/0958-1669(94)90073-6 |
0.399 |
|
| 1994 |
Park H, Davies MV, Langland JO, Chang HW, Nam YS, Tartaglia J, Paoletti E, Jacobs BL, Kaufman RJ, Venkatesan S. TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR. Proceedings of the National Academy of Sciences of the United States of America. 91: 4713-7. PMID 7515177 DOI: 10.1073/Pnas.91.11.4713 |
0.398 |
|
| 1993 |
Rehemtulla A, Roth DA, Wasley LC, Kuliopulos A, Walsh CT, Furie B, Furie BC, Kaufman RJ. In vitro and in vivo functional characterization of bovine vitamin K-dependent gamma-carboxylase expressed in Chinese hamster ovary cells. Proceedings of the National Academy of Sciences of the United States of America. 90: 4611-5. PMID 8506307 DOI: 10.1073/Pnas.90.10.4611 |
0.323 |
|
| 1993 |
Pittman DD, Kaufman RJ. Site-directed mutagenesis and expression of coagulation factors VIII and V in mammalian cells. Methods in Enzymology. 222: 236-60. PMID 8412797 DOI: 10.1016/0076-6879(93)22017-A |
0.361 |
|
| 1993 |
Roth DA, Rehemtulla A, Kaufman RJ, Walsh CT, Furie B, Furie BC. Expression of bovine vitamin K-dependent carboxylase activity in baculovirus-infected insect cells. Proceedings of the National Academy of Sciences of the United States of America. 90: 8372-6. PMID 8378308 DOI: 10.1073/Pnas.90.18.8372 |
0.323 |
|
| 1993 |
Lynch CM, Israel DI, Kaufman RJ, Miller AD. Sequences in the coding region of clotting factor VIII act as dominant inhibitors of RNA accumulation and protein production. Human Gene Therapy. 4: 259-72. PMID 8338874 DOI: 10.1089/Hum.1993.4.3-259 |
0.343 |
|
| 1993 |
Rehemtulla A, Barr PJ, Rhodes CJ, Kaufman RJ. PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE. Biochemistry. 32: 11586-90. PMID 8218226 DOI: 10.1021/Bi00094A015 |
0.363 |
|
| 1993 |
Pittman D, Alderman E, Tomkinson K, Wang J, Giles A, Kaufman R. Biochemical, immunological, and in vivo functional characterization of B-domain-deleted factor VIII Blood. 81: 2925-2935. DOI: 10.1182/Blood.V81.11.2925.2925 |
0.307 |
|
| 1992 |
Kaufman RJ. Biological regulation of factor VIII activity. Annual Review of Medicine. 43: 325-39. PMID 1580593 DOI: 10.1146/Annurev.Me.43.020192.001545 |
0.333 |
|
| 1992 |
Pittman DD, Wang JH, Kaufman RJ. Identification and functional importance of tyrosine sulfate residues within recombinant factor VIII. Biochemistry. 31: 3315-25. PMID 1554716 DOI: 10.1021/Bi00128A003 |
0.323 |
|
| 1992 |
Chang AC, Nunberg JN, Kaufman RJ, Erlich HA, Schimke RT, Cohen SN. Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase. 1978. Biotechnology (Reading, Mass.). 24: 330-6. PMID 1422034 |
0.441 |
|
| 1992 |
Israel DI, Nove J, Kerns KM, Moutsatsos IK, Kaufman RJ. Expression and characterization of bone morphogenetic protein-2 in Chinese hamster ovary cells. Growth Factors (Chur, Switzerland). 7: 139-50. PMID 1419071 DOI: 10.3109/08977199209046403 |
0.32 |
|
| 1992 |
Dorner AJ, Wasley LC, Kaufman RJ. Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cells. The Embo Journal. 11: 1563-71. PMID 1373378 DOI: 10.1002/J.1460-2075.1992.Tb05201.X |
0.483 |
|
| 1992 |
Rehemtulla A, Kaufman RJ. Protein processing within the secretory pathway. Current Opinion in Biotechnology. 3: 560-5. PMID 1368940 DOI: 10.1016/0958-1669(92)90086-X |
0.342 |
|
| 1992 |
Davies MV, Kaufman RJ. Internal translation initiation in the design of improved expression vectors. Current Opinion in Biotechnology. 3: 512-7. PMID 1368936 DOI: 10.1016/0958-1669(92)90079-X |
0.319 |
|
| 1992 |
Kaufman RJ. Mammalian recombinant proteins: structure, function and immunological analysis. Current Opinion in Biotechnology. 1: 141-50. PMID 1367851 DOI: 10.1016/0958-1669(90)90023-E |
0.311 |
|
| 1992 |
Kaufman RJ. Developing rDNA products for treatment of hemophilia A. Trends in Biotechnology. 9: 353-9. PMID 1367761 DOI: 10.1016/0167-7799(91)90118-2 |
0.309 |
|
| 1992 |
Rehemtulla A, Dorner AJ, Kaufman RJ. Regulation of PACE propeptide-processing activity: requirement for a post-endoplasmic reticulum compartment and autoproteolytic activation. Proceedings of the National Academy of Sciences of the United States of America. 89: 8235-9. PMID 1325651 DOI: 10.1073/Pnas.89.17.8235 |
0.359 |
|
| 1992 |
Koo HM, Brown AMC, Kaufman RJ, Prorock CM, Ron Y, Dougherty JP. A spleen necrosis virus-based retroviral vector which expresses two genes from a dicistronic mRNA Virology. 186: 669-675. PMID 1310190 DOI: 10.1016/0042-6822(92)90033-L |
0.31 |
|
| 1991 |
Wasley LC, Timony G, Murtha P, Stoudemire J, Dorner AJ, Caro J, Krieger M, Kaufman RJ. The importance of N- and O-linked oligosaccharides for the biosynthesis and in vitro and in vivo biologic activities of erythropoietin. Blood. 77: 2624-32. PMID 2043765 DOI: 10.1182/Blood.V77.12.2624.Bloodjournal77122624 |
0.3 |
|
| 1991 |
Messier TL, Pittman DD, Long GL, Kaufman RJ, Church WR. Cloning and expression in COS-1 cells of a full-length cDNA encoding human coagulation factor X. Gene. 99: 291-4. PMID 1902434 DOI: 10.1016/0378-1119(91)90141-W |
0.318 |
|
| 1991 |
Wood CR, Morris GE, Alderman EM, Fouser L, Kaufman RJ. An internal ribosome binding site can be used to select for homologous recombinants at an immunoglobulin heavy-chain locus Proceedings of the National Academy of Sciences of the United States of America. 88: 8006-8010. PMID 1654552 DOI: 10.1073/Pnas.88.18.8006 |
0.341 |
|
| 1991 |
Kaufman RJ, Davies MV, Wasley LC, Michnick D. Improved vectors for stable expression of foreign genes in mammalian cells by use of the untranslated leader sequence from EMC virus. Nucleic Acids Research. 19: 4485-90. PMID 1653417 DOI: 10.1093/Nar/19.16.4485 |
0.333 |
|
| 1991 |
Kaufman RJ. Control of translation initiation in mammalian cells. Genetic Engineering. 12: 243-73. PMID 1366704 DOI: 10.1007/978-1-4613-0641-2_13 |
0.355 |
|
| 1990 |
Dorner AJ, Kaufman RJ. Analysis of synthesis, processing, and secretion of proteins expressed in mammalian cells. Methods in Enzymology. 185: 577-96. PMID 2381330 DOI: 10.1016/0076-6879(90)85046-Q |
0.367 |
|
| 1990 |
Dorner AJ, Wasley LC, Raney P, Haugejorden S, Green M, Kaufman RJ. The stress response in Chinese hamster ovary cells. Regulation of ERp72 and protein disulfide isomerase expression and secretion. The Journal of Biological Chemistry. 265: 22029-34. PMID 2254345 |
0.39 |
|
| 1990 |
Wise RJ, Barr PJ, Wong PA, Kiefer MC, Brake AJ, Kaufman RJ. Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site. Proceedings of the National Academy of Sciences of the United States of America. 87: 9378-82. PMID 2251280 DOI: 10.1073/Pnas.87.23.9378 |
0.345 |
|
| 1990 |
Dorner AJ, Wasley LC, Kaufman RJ. Protein dissociation from GRP78 and secretion are blocked by depletion of cellular ATP levels. Proceedings of the National Academy of Sciences of the United States of America. 87: 7429-32. PMID 2120699 DOI: 10.1073/Pnas.87.19.7429 |
0.373 |
|
| 1990 |
Milburn SC, Hershey JW, Davies MV, Kelleher K, Kaufman RJ. Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif. The Embo Journal. 9: 2783-2790. DOI: 10.1002/J.1460-2075.1990.Tb07466.X |
0.325 |
|
| 1989 |
Kaufman RJ, Davies MV, Pathak VK, Hershey JW. The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs. Molecular and Cellular Biology. 9: 946-58. PMID 2657393 DOI: 10.1128/Mcb.9.3.946 |
0.319 |
|
| 1989 |
Davies MV, Furtado M, Hershey JW, Thimmappaya B, Kaufman RJ. Complementation of adenovirus virus-associated RNA I gene deletion by expression of a mutant eukaryotic translation initiation factor. Proceedings of the National Academy of Sciences of the United States of America. 86: 9163-7. PMID 2594757 DOI: 10.1073/Pnas.86.23.9163 |
0.328 |
|
| 1989 |
Israel DI, Kaufman RJ. Highly inducible expression from vectors containing multiple GRE's in CHO cells overexpressing the glucocorticoid receptor. Nucleic Acids Research. 17: 4589-604. PMID 2546123 DOI: 10.1093/Nar/17.12.4589 |
0.346 |
|
| 1989 |
Jang SK, Davies MV, Kaufman RJ, Wimmer E. Initiation of protein synthesis by internal entry of ribosomes into the 5' nontranslated region of encephalomyocarditis virus RNA in vivo. Journal of Virology. 63: 1651-60. PMID 2538648 DOI: 10.1128/Jvi.63.4.1651-1660.1989 |
0.353 |
|
| 1989 |
Kaufman RJ, Wasley LC, Davies MV, Wise RJ, Israel DI, Dorner AJ. Effect of von Willebrand factor coexpression on the synthesis and secretion of factor VIII in Chinese hamster ovary cells. Molecular and Cellular Biology. 9: 1233-42. PMID 2498645 DOI: 10.1128/Mcb.9.3.1233 |
0.361 |
|
| 1988 |
Wise RJ, Pittman DD, Handin RI, Kaufman RJ, Orkin SH. The propeptide of von Willebrand factor independently mediates the assembly of von Willebrand multimers. Cell. 52: 229-36. PMID 3124962 DOI: 10.1016/0092-8674(88)90511-9 |
0.319 |
|
| 1988 |
Dorner AJ, Krane MG, Kaufman RJ. Reduction of endogenous GRP78 levels improves secretion of a heterologous protein in CHO cells. Molecular and Cellular Biology. 8: 4063-70. PMID 2460739 DOI: 10.1128/Mcb.8.10.4063 |
0.387 |
|
| 1987 |
Bonthron DT, Handin RI, Kaufman RJ, Wasley LC, Orr EC, Mitsock LM, Ewenstein B, Loscalzo J, Ginsburg D, Orkin SH. Structure of pre-pro-von Willebrand factor and its expression in heterologous cells. Nature. 324: 270-3. PMID 3491324 DOI: 10.1038/324270A0 |
0.311 |
|
| 1987 |
Kaufman R, Murtha P, Davies M. Translational efficiency of polycistronic mRNAs and their utilization to express heterologous genes in mammalian cells. The Embo Journal. 6: 187-193. DOI: 10.1002/J.1460-2075.1987.Tb04737.X |
0.39 |
|
| 1985 |
Kaufman RJ, Wasley LC, Spiliotes AJ, Gossels SD, Latt SA, Larsen GR, Kay RM. Coamplification and coexpression of human tissue-type plasminogen activator and murine dihydrofolate reductase sequences in Chinese hamster ovary cells. Molecular and Cellular Biology. 5: 1750-9. PMID 4040603 DOI: 10.1128/Mcb.5.7.1750 |
0.302 |
|
| 1985 |
Gasson JC, Golde DW, Kaufman SE, Westbrook CA, Hewick RM, Kaufman RJ, Wong GG, Temple PA, Leary AC, Brown EL. Molecular characterization and expression of the gene encoding human erythroid-potentiating activity. Nature. 315: 768-71. PMID 3839290 DOI: 10.1038/315768A0 |
0.334 |
|
| 1985 |
Jacobs K, Shoemaker C, Rudersdorf R, Neill SD, Kaufman RJ, Mufson A, Seehra J, Jones SS, Hewick R, Fritsch EF. Isolation and characterization of genomic and cDNA clones of human erythropoietin. Nature. 313: 806-10. PMID 3838366 DOI: 10.1038/313806A0 |
0.314 |
|
| 1984 |
Toole JJ, Knopf JL, Wozney JM, Sultzman LA, Buecker JL, Pittman DD, Kaufman RJ, Brown E, Shoemaker C, Orr EC, Amphlett GW, Foster WB, Coe ML, Knutson GJ, Fass DN, et al. Molecular cloning of a cDNA encoding human antihaemophilic factor. Nature. 312: 342-347. PMID 6438528 DOI: 10.1038/312342A0 |
0.311 |
|
| 1984 |
Clark SC, Arya SK, Wong-Staal F, Matsumoto-Kobayashi M, Kay RM, Kaufman RJ, Brown EL, Shoemaker C, Copeland T, Oroszlan S. Human T-cell growth factor: partial amino acid sequence, cDNA cloning, and organization and expression in normal and leukemic cells. Proceedings of the National Academy of Sciences of the United States of America. 81: 2543-7. PMID 6201860 DOI: 10.1073/Pnas.81.8.2543 |
0.336 |
|
| 1984 |
Kingston RE, Kaufman RJ, Sharp PA. Regulation of transcription of the adenovirus EII promoter by EIa gene products: absence of sequence specificity. Molecular and Cellular Biology. 4: 1970-7. PMID 6095034 DOI: 10.1128/Mcb.4.10.1970 |
0.643 |
|
| 1983 |
Kaufman RJ, Sharp PA, Latt SA. Evolution of chromosomal regions containing transfected and amplified dihydrofolate reductase sequences. Molecular and Cellular Biology. 3: 699-711. PMID 6855772 DOI: 10.1128/Mcb.3.4.699 |
0.445 |
|
| 1983 |
Kaufman RJ, Sharp PA. Growth-dependent expression of dihydrofolate reductase mRNA from modular cDNA genes. Molecular and Cellular Biology. 3: 1598-608. PMID 6138708 DOI: 10.1128/Mcb.3.9.1598 |
0.516 |
|
| 1982 |
Schimke RT, Brown PC, Kaufman RJ. Gene amplification and drug resistance in mammalian cells. National Cancer Institute Monograph. 60: 79-86. PMID 7121575 |
0.501 |
|
| 1982 |
Kaufman RJ, Sharp PA. Amplification and expression of sequences cotransfected with a modular dihydrofolate reductase complementary dna gene. Journal of Molecular Biology. 159: 601-21. PMID 6292436 DOI: 10.1016/0022-2836(82)90103-6 |
0.475 |
|
| 1982 |
Kaufman RJ, Sharp PA. Construction of a modular dihydrofolate reductase cDNA gene: analysis of signals utilized for efficient expression. Molecular and Cellular Biology. 2: 1304-19. PMID 6131378 DOI: 10.1128/Mcb.2.11.1304 |
0.518 |
|
| 1981 |
Kaufman RJ, Brown PC, Schimke RT. Loss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines. Molecular and Cellular Biology. 1: 1084-93. PMID 7346713 DOI: 10.1128/Mcb.1.12.1084 |
0.535 |
|
| 1981 |
Kaufman RJ, Schimke RT. Amplification and loss of dihydrofolate reductase genes in a Chinese hamster ovary cell line. Molecular and Cellular Biology. 1: 1069-76. PMID 7346712 |
0.489 |
|
| 1981 |
Schimke RT, Brown PC, Kaufman RJ, McGrogan M, Slate DL. Chromosomal and extrachromosomal localization of amplified dihydrofolate reductase genes in cultured mammalian cells. Cold Spring Harbor Symposia On Quantitative Biology. 45: 785-97. PMID 6942951 DOI: 10.1101/Sqb.1981.045.01.097 |
0.457 |
|
| 1981 |
Handa H, Kaufman RJ, Manley J, Gefter M, Sharp PA. Transcription of Simian virus 40 DNA in a HeLa whole cell extract. The Journal of Biological Chemistry. 256: 478-82. PMID 6256354 |
0.508 |
|
| 1980 |
Nunberg JH, Kaufman RJ, Chang AC, Cohen SN, Schimke RT. Structure and genomic organization of the mouse dihydrofolate reductase gene. Cell. 19: 355-64. PMID 6244105 DOI: 10.1016/0092-8674(80)90510-3 |
0.475 |
|
| 1980 |
Chang AC, Erlich HA, Gunsalus RP, Nunberg JH, Kaufman RJ, Schimke RT, Cohen SN. Initiation of protein synthesis in bacteria at a translational start codon of mamalian cDNA: effects of the preceding nucleotide sequence. Proceedings of the National Academy of Sciences of the United States of America. 77: 1442-6. PMID 6154933 DOI: 10.1073/Pnas.77.3.1442 |
0.582 |
|
| 1979 |
Dolnick BJ, Berenson RJ, Bertino JR, Kaufman RJ, Nunberg JH, Schimke RT. Correlation of dihydrofolate reductase elevation with gene amplification in a homogeneously staining chromosomal region in L5178Y cells. The Journal of Cell Biology. 83: 394-402. PMID 500787 DOI: 10.1083/Jcb.83.2.394 |
0.559 |
|
| 1979 |
Kaufman RJ, Brown PC, Schimke RT. Amplified dihydrofolate reductase genes in unstably methotrexate-resistant cells are associated with double minute chromosomes. Proceedings of the National Academy of Sciences of the United States of America. 76: 5669-73. PMID 293670 DOI: 10.1073/Pnas.76.11.5669 |
0.535 |
|
| 1979 |
Schimke RT, Kaufman RJ, Nunberg JH, Dana SL. Studies on the amplification of dihydrofolate reductase genes in methotrexate-resistant cultured mouse cells. Cold Spring Harbor Symposia On Quantitative Biology. 43: 1297-303. PMID 290443 DOI: 10.1101/Sqb.1979.043.01.148 |
0.467 |
|
| 1978 |
Schimke RT, Kaufman RJ, Alt FW, Kellems RF. Gene amplification and drug resistance in cultured murine cells. Science (New York, N.Y.). 202: 1051-5. PMID 715457 DOI: 10.1126/Science.715457 |
0.554 |
|
| 1978 |
Kaufman RJ, Bertino JR, Schimke RT. Quantitation of dihydrofolate reductase in individual parental and methotrexate-resistant murine cells. Use of a fluorescence activated cell sorter. The Journal of Biological Chemistry. 253: 5852-60. PMID 670236 |
0.448 |
|
| 1978 |
Chang AC, Nunberg JH, Kaufman RJ, Erlich HA, Schimke RT, Cohen SN. Phenotypic expression in E. coli of a DNA sequence coding for mouse dihydrofolate reductase. Nature. 275: 617-24. PMID 360074 DOI: 10.1038/275617A0 |
0.49 |
|
| 1978 |
Nunberg JH, Kaufman RJ, Schimke RT, Urlaub G, Chasin LA. Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexate-resistant Chinese hamster ovary cell line. Proceedings of the National Academy of Sciences of the United States of America. 75: 5553-6. PMID 281704 DOI: 10.1073/Pnas.75.11.5553 |
0.537 |
|
| 1978 |
Schimke RT, Alt FW, Kellems RE, Kaufman RJ, Bertino JR. Amplification of dihydrofolate reductase genes in methotrexate-resistant cultured mouse cells. Cold Spring Harbor Symposia On Quantitative Biology. 42: 649-57. PMID 277312 DOI: 10.1101/Sqb.1978.042.01.067 |
0.565 |
|
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