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Wesley R. Legant, Ph.D. - Publications

Affiliations: 
Bioengineering University of Pennsylvania, Philadelphia, PA, United States 
Area:
Tissue Microfabrication
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34 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Doherty EL, Aw WY, Warren EC, Hockenberry M, Whitworth CP, Krohn G, Howell S, Diekman BO, Legant WR, Nia HT, Hickey AJ, Polacheck WJ. Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics. Acta Biomaterialia. PMID 37187299 DOI: 10.1016/j.actbio.2023.05.015  0.31
2022 Hakeem RM, Subramanian BC, Hockenberry MA, King ZT, Butler MT, Legant WR, Bear JE. A Photopolymerized Hydrogel System with Dual Stiffness Gradients Reveals Distinct Actomyosin-Based Mechano-Responses in Fibroblast Durotaxis. Acs Nano. PMID 36475639 DOI: 10.1021/acsnano.2c05941  0.354
2022 Hockenberry MA, Legant WR. Cells in the mechanical spotlight. Biophysical Journal. 121: 3571-3572. PMID 36115341 DOI: 10.1016/j.bpj.2022.09.003  0.306
2020 Xie L, Dong P, Chen X, Hsieh TS, Banala S, De Marzio M, English BP, Qi Y, Jung SK, Kieffer-Kwon KR, Legant WR, Hansen AS, Schulmann A, Casellas R, Zhang B, et al. 3D ATAC-PALM: super-resolution imaging of the accessible genome. Nature Methods. PMID 32203384 DOI: 10.1038/S41592-020-0775-2  0.318
2019 O'Shaughnessy EC, Stone OJ, LaFosse PK, Azoitei ML, Tsygankov D, Heddleston JM, Legant WR, Wittchen ES, Burridge K, Elston TC, Betzig E, Chew TL, Adalsteinsson D, Hahn KM. Software for lattice light-sheet imaging of FRET biosensors, illustrated with a new Rap1 biosensor. The Journal of Cell Biology. PMID 31444239 DOI: 10.1083/Jcb.201903019  0.338
2019 David AF, Roudot P, Legant WR, Betzig E, Danuser G, Gerlich DW. Augmin accumulation on long-lived microtubules drives amplification and kinetochore-directed growth. The Journal of Cell Biology. PMID 31113824 DOI: 10.1083/Jcb.201805044  0.358
2017 Valm AM, Cohen S, Legant WR, Melunis J, Hershberg U, Wait E, Cohen AR, Davidson MW, Betzig E, Lippincott-Schwartz J. Applying systems-level spectral imaging and analysis to reveal the organelle interactome. Nature. PMID 28538724 DOI: 10.1038/Nature22369  0.395
2016 Aguet F, Upadhyayula S, Gaudin R, Chou YY, Cocucci E, He K, Chen BC, Mosaliganti K, Pasham M, Skillern W, Legant WR, Liu TL, Findlay G, Marino E, Danuser G, et al. Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy. Molecular Biology of the Cell. PMID 27535432 DOI: 10.1091/Mbc.E16-03-0164  0.405
2016 Li L, Liu H, Dong P, Li D, Legant WR, Grimm JB, Lavis LD, Betzig E, Tjian R, Liu Z. Real-time imaging of Huntingtin aggregates diverting target search and gene transcription. Elife. 5. PMID 27484239 DOI: 10.7554/Elife.17056  0.305
2016 Imhof S, Fragoso C, Hemphill A, von Schubert C, Li D, Legant W, Betzig E, Roditi I. Flagellar membrane fusion and protein exchange in trypanosomes; a new form of cell-cell communication? F1000research. 5: 682. PMID 27239276 DOI: 10.12688/F1000Research.8249.1  0.38
2016 Legant WR, Shao L, Grimm JB, Brown TA, Milkie DE, Avants BB, Lavis LD, Betzig E. High-density three-dimensional localization microscopy across large volumes. Nature Methods. PMID 26950745 DOI: 10.1038/Nmeth.3797  0.352
2015 Yamashita N, Morita M, Legant WR, Chen BC, Betzig E, Yokota H, Mimori-Kiyosue Y. Three-dimensional tracking of plus-tips by lattice light-sheet microscopy permits the quantification of microtubule growth trajectories within the mitotic apparatus. Journal of Biomedical Optics. 20: 101206. PMID 26527322 DOI: 10.1117/1.Jbo.20.10.101206  0.4
2015 Ritter AT, Asano Y, Stinchcombe JC, Dieckmann NM, Chen BC, Gawden-Bone C, van Engelenburg S, Legant W, Gao L, Davidson MW, Betzig E, Lippincott-Schwartz J, Griffiths GM. Actin depletion initiates events leading to granule secretion at the immunological synapse. Immunity. 42: 864-76. PMID 25992860 DOI: 10.1016/J.Immuni.2015.04.013  0.329
2015 Kural C, Akatay AA, Gaudin R, Chen BC, Legant WR, Betzig E, Kirchhausen T. Asymmetric formation of coated pits on dorsal and ventral surfaces at the leading edges of motile cells and on protrusions of immobile cells. Molecular Biology of the Cell. 26: 2044-53. PMID 25851602 DOI: 10.1091/Mbc.E15-01-0055  0.335
2014 Liu Z, Legant WR, Chen BC, Li L, Grimm JB, Lavis LD, Betzig E, Tjian R. 3D imaging of Sox2 enhancer clusters in embryonic stem cells. Elife. 3: e04236. PMID 25537195 DOI: 10.7554/Elife.04236  0.338
2014 Chen BC, Legant WR, Wang K, Shao L, Milkie DE, Davidson MW, Janetopoulos C, Wu XS, Hammer JA, Liu Z, English BP, Mimori-Kiyosue Y, Romero DP, Ritter AT, Lippincott-Schwartz J, et al. Lattice light-sheet microscopy: imaging molecules to embryos at high spatiotemporal resolution. Science (New York, N.Y.). 346: 1257998. PMID 25342811 DOI: 10.1126/Science.1257998  0.391
2014 Chen J, Zhang Z, Li L, Chen BC, Revyakin A, Hajj B, Legant W, Dahan M, Lionnet T, Betzig E, Tjian R, Liu Z. Single-molecule dynamics of enhanceosome assembly in embryonic stem cells. Cell. 156: 1274-85. PMID 24630727 DOI: 10.1016/J.Cell.2014.01.062  0.309
2014 Ramade A, Legant WR, Picart C, Chen CS, Boudou T. Microfabrication of a platform to measure and manipulate the mechanics of engineered microtissues. Methods in Cell Biology. 121: 191-211. PMID 24560511 DOI: 10.1016/B978-0-12-800281-0.00013-0  0.478
2014 Liu Z, Legant WR, Chen B, Li L, Grimm JB, Lavis LD, Betzig E, Tjian R. Author response: 3D imaging of Sox2 enhancer clusters in embryonic stem cells Elife. DOI: 10.7554/Elife.04236.035  0.319
2013 Grimm JB, Sung AJ, Legant WR, Hulamm P, Matlosz SM, Betzig E, Lavis LD. Carbofluoresceins and carborhodamines as scaffolds for high-contrast fluorogenic probes. Acs Chemical Biology. 8: 1303-10. PMID 23557713 DOI: 10.1021/Cb4000822  0.342
2013 Khetan S, Guvendiren M, Legant WR, Cohen DM, Chen CS, Burdick JA. Degradation-mediated cellular traction directs stem cell fate in covalently crosslinked three-dimensional hydrogels. Nature Materials. 12: 458-65. PMID 23524375 DOI: 10.1038/Nmat3586  0.587
2013 Legant WR, Choi CK, Miller JS, Shao L, Gao L, Betzig E, Chen CS. Multidimensional traction force microscopy reveals out-of-plane rotational moments about focal adhesions. Proceedings of the National Academy of Sciences of the United States of America. 110: 881-6. PMID 23277584 DOI: 10.1073/Pnas.1207997110  0.634
2013 West AR, Zaman N, Cole DJ, Walker MJ, Legant WR, Boudou T, Chen CS, Favreau JT, Gaudette GR, Cowley EA, Maksym GN. Development and characterization of a 3D multicell microtissue culture model of airway smooth muscle. American Journal of Physiology. Lung Cellular and Molecular Physiology. 304: L4-16. PMID 23125251 DOI: 10.1152/Ajplung.00168.2012  0.573
2012 Lee SL, Nekouzadeh A, Butler B, Pryse KM, McConnaughey WB, Nathan AC, Legant WR, Schaefer PM, Pless RB, Elson EL, Genin GM. Physically-induced cytoskeleton remodeling of cells in three-dimensional culture. Plos One. 7: e45512. PMID 23300512 DOI: 10.1371/Journal.Pone.0045512  0.436
2012 Legant WR, Chen CS, Vogel V. Force-induced fibronectin assembly and matrix remodeling in a 3D microtissue model of tissue morphogenesis. Integrative Biology : Quantitative Biosciences From Nano to Macro. 4: 1164-74. PMID 22961409 DOI: 10.1039/C2Ib20059G  0.615
2012 Boudou T, Legant WR, Mu A, Borochin MA, Thavandiran N, Radisic M, Zandstra PW, Epstein JA, Margulies KB, Chen CS. A microfabricated platform to measure and manipulate the mechanics of engineered cardiac microtissues. Tissue Engineering. Part A. 18: 910-9. PMID 22092279 DOI: 10.1089/Ten.Tea.2011.0341  0.588
2012 Khetan S, Legant WR, Chen CS, Burdick JA. Stem cell fate within 3D hydrogels is mediated by network structure-dependent traction generation Asme 2012 Summer Bioengineering Conference, Sbc 2012. 527-528. DOI: 10.1115/SBC2012-80277  0.421
2011 Collier IE, Legant W, Marmer B, Lubman O, Saffarian S, Wakatsuki T, Elson E, Goldberg GI. Diffusion of MMPs on the surface of collagen fibrils: the mobile cell surface-collagen substratum interface. Plos One. 6: e24029. PMID 21912660 DOI: 10.1371/Journal.Pone.0024029  0.399
2011 Legant WR, Miller JS, Blakely BL, Cohen D, Genin GM, Chen CS. A general Approach to Measure Three-Dimensional Forces from Cells Biophysical Journal. 100: 190a. DOI: 10.1016/J.Bpj.2010.12.1258  0.734
2010 Legant WR, Miller JS, Blakely BL, Cohen DM, Genin GM, Chen CS. Measurement of mechanical tractions exerted by cells in three-dimensional matrices. Nature Methods. 7: 969-71. PMID 21076420 DOI: 10.1038/Nmeth.1531  0.727
2010 Miller JS, Shen CJ, Legant WR, Baranski JD, Blakely BL, Chen CS. Bioactive hydrogels made from step-growth derived PEG-peptide macromers. Biomaterials. 31: 3736-43. PMID 20138664 DOI: 10.1016/J.Biomaterials.2010.01.058  0.59
2009 Legant WR, Pathak A, Yang MT, Deshpande VS, McMeeking RM, Chen CS. Microfabricated tissue gauges to measure and manipulate forces from 3D microtissues. Proceedings of the National Academy of Sciences of the United States of America. 106: 10097-102. PMID 19541627 DOI: 10.1073/Pnas.0900174106  0.726
2009 Marquez JP, Legant W, Lam V, Cayemberg A, Elson E, Wakatsuki T. High-throughput measurements of hydrogel tissue construct mechanics. Tissue Engineering. Part C, Methods. 15: 181-90. PMID 19196123 DOI: 10.1089/Ten.Tec.2008.0347  0.494
2007 Desai R, Yang M, Sniadecki N, Legant W, Chen C. Microfabricated post-array-detectors (mPADs): an approach to isolate mechanical forces. Journal of Visualized Experiments : Jove. 311. PMID 18989444 DOI: 10.3791/311  0.755
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