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Peter Gmeiner - Publications

Affiliations: 
Pharmaceutical Chemistry Friedrich-Alexander University, Erlangen, Germany, Erlangen, Bayern, Germany 
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Year Citation  Score
2024 Chen G, Staffen N, Wu Z, Xu X, Pan J, Inoue A, Shi T, Gmeiner P, Du Y, Xu J. Structural and functional characterization of the endogenous agonist for orphan receptor GPR3. Cell Research. PMID 38287118 DOI: 10.1038/s41422-023-00919-8  0.39
2023 Lahmy R, Hübner H, Lachmann D, Gmeiner P, König B. Development of Photoswitchable Tethered Ligands that Target the μ-Opioid Receptor. Chemmedchem. e202300228. PMID 37817331 DOI: 10.1002/cmdc.202300228  0.456
2023 Graßl F, Bock L, Huete-Huerta González Á, Schiller M, Gmeiner P, König J, Fromm MF, Hübner H, Heinrich MR. Exploring Structural Determinants of Bias among D4 Subtype-Selective Dopamine Receptor Agonists. Journal of Medicinal Chemistry. PMID 37450764 DOI: 10.1021/acs.jmedchem.3c00537  0.604
2023 Saller J, List C, Hübner H, Gmeiner P, Clark T, Pischetsrieder M. Identification and quantification of kukoamine A and kukoamine B as novel μ-opioid receptor agonists in potato and other solanaceous plants. Food Chemistry. 427: 136637. PMID 37385059 DOI: 10.1016/j.foodchem.2023.136637  0.348
2023 Kühl T, Georgieva MG, Hübner H, Lazarova M, Vogel M, Haas B, Peeva MI, Balacheva AA, Bogdanov IP, Milella L, Ponticelli M, Garev T, Faraone I, Detcheva R, Minchev B, ... ... Gmeiner P, et al. Neurotensin(8-13) analogs as dual NTS1 and NTS2 receptor ligands with enhanced effects on a mouse model of Parkinson's disease. European Journal of Medicinal Chemistry. 254: 115386. PMID 37094450 DOI: 10.1016/j.ejmech.2023.115386  0.353
2023 Xu X, Shonberg J, Kaindl J, Clark MJ, Stößel A, Maul L, Mayer D, Hübner H, Hirata K, Venkatakrishnan AJ, Dror RO, Kobilka BK, Sunahara RK, Liu X, Gmeiner P. Constrained catecholamines gain βAR selectivity through allosteric effects on pocket dynamics. Nature Communications. 14: 2138. PMID 37059717 DOI: 10.1038/s41467-023-37808-y  0.401
2023 Fierro F, Peri L, Hübner H, Tabor-Schkade A, Waterloo L, Löber S, Pfeiffer T, Weikert D, Dingjan T, Margulis E, Gmeiner P, Niv MY. Inhibiting a promiscuous GPCR: iterative discovery of bitter taste receptor ligands. Cellular and Molecular Life Sciences : Cmls. 80: 114. PMID 37012410 DOI: 10.1007/s00018-023-04765-0  0.407
2023 Panel N, Vo DD, Kahlous NA, Hübner H, Tiedt S, Matricon P, Pacalon J, Fleetwood O, Kampen S, Luttens A, Delemotte L, Kihlberg J, Gmeiner P, Carlsson J. Design of Drug Efficacy Guided by Free Energy Simulations of the β2-Adrenoceptor. Angewandte Chemie (International Ed. in English). e202218959. PMID 36914577 DOI: 10.1002/anie.202218959  0.369
2023 Waterloo L, Hübner H, Fierro F, Pfeiffer T, Brox R, Löber S, Weikert D, Niv MY, Gmeiner P. Discovery of 2-Aminopyrimidines as Potent Agonists for the Bitter Taste Receptor TAS2R14. Journal of Medicinal Chemistry. 66: 3499-3521. PMID 36847646 DOI: 10.1021/acs.jmedchem.2c01997  0.369
2023 Xu J, Wang Q, Hübner H, Hu Y, Niu X, Wang H, Maeda S, Inoue A, Tao Y, Gmeiner P, Du Y, Jin C, Kobilka BK. Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature Communications. 14: 376. PMID 36690613 DOI: 10.1038/s41467-022-35726-z  0.353
2022 Waterloo LAW, Löber S, Gmeiner P. The Bitter Taste Receptor TAS2R14 as a Drug Target. Chimia. 76: 418-424. PMID 38069713 DOI: 10.2533/chimia.2022.418  0.368
2022 Wenk D, Khan S, Ignatchenko V, Hübner H, Gmeiner P, Weikert D, Pischetsrieder M, Kislinger T. Phosphoproteomic Analysis of Dopamine D2 Receptor Signaling Reveals Interplay of G Protein- and β-Arrestin-Mediated Effects. Journal of Proteome Research. 22: 259-271. PMID 36508580 DOI: 10.1021/acs.jproteome.2c00707  0.39
2022 Köckenberger J, Fischer O, Konopa A, Bergwinkl S, Mühlich S, Gmeiner P, Kutta RJ, Hübner H, Keller M, Heinrich MR. Synthesis, Characterization, and Application of Muscarinergic M Receptor Ligands Linked to Fluorescent Dyes. Journal of Medicinal Chemistry. PMID 36484801 DOI: 10.1021/acs.jmedchem.2c01376  0.338
2022 Fink EA, Xu J, Hübner H, Braz JM, Seemann P, Avet C, Craik V, Weikert D, Schmidt MF, Webb CM, Tolmachova NA, Moroz YS, Huang XP, Kalyanaraman C, Gahbauer S, ... ... Gmeiner P, et al. Structure-based discovery of nonopioid analgesics acting through the α-adrenergic receptor. Science (New York, N.Y.). 377: eabn7065. PMID 36173843 DOI: 10.1126/science.abn7065  0.359
2022 Lahmy R, Hübner H, Schmidt MF, Lachmann D, Gmeiner P, König B. Photochromic Fentanyl Derivatives for Controlled µ-Opioid Receptor Activation. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 35899620 DOI: 10.1002/chem.202201515  0.373
2022 Chen G, Xu J, Inoue A, Schmidt MF, Bai C, Lu Q, Gmeiner P, Liu Z, Du Y. Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex. Nature Communications. 13: 2375. PMID 35501348 DOI: 10.1038/s41467-022-30081-5  0.315
2022 Einsiedel J, Schmidt MF, Hübner H, Gmeiner P. Development of disulfide-functionalized peptides covalently binding G protein-coupled receptors. Bioorganic & Medicinal Chemistry. 61: 116720. PMID 35334449 DOI: 10.1016/j.bmc.2022.116720  0.403
2022 Xu J, Cao S, Hübner H, Weikert D, Chen G, Lu Q, Yuan D, Gmeiner P, Liu Z, Du Y. Structural insights into ligand recognition, activation, and signaling of the α adrenergic receptor. Science Advances. 8: eabj5347. PMID 35245122 DOI: 10.1126/sciadv.abj5347  0.358
2021 Nagai R, Sugimachi A, Tanimoto Y, Suzuki KGN, Hayashi F, Weikert D, Gmeiner P, Kasai RS, Morigaki K. Functional Reconstitution of Dopamine D2 Receptor into a Supported Model Membrane in a Nanometric Confinement. Advanced Biology. e2100636. PMID 34761565 DOI: 10.1002/adbi.202100636  0.379
2021 Budzinski J, Maschauer S, Kobayashi H, Couvineau P, Vogt H, Gmeiner P, Roggenhofer A, Prante O, Bouvier M, Weikert D. Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer. Communications Biology. 4: 1062. PMID 34508168 DOI: 10.1038/s42003-021-02574-4  0.543
2021 Boritzki V, Hübner H, Allikalt A, Gmeiner P, Wöhrl BM. Optimizing the Expression of Human Dopamine Receptors in . International Journal of Molecular Sciences. 22. PMID 34445358 DOI: 10.3390/ijms22168647  0.517
2021 Tropmann K, Bresinsky M, Forster L, Mönnich D, Buschauer A, Wittmann HJ, Hübner H, Gmeiner P, Pockes S, Strasser A. Abolishing Dopamine D/D Receptor Affinity of Subtype-Selective Carbamoylguanidine-Type Histamine H Receptor Agonists. Journal of Medicinal Chemistry. 64: 8684-8709. PMID 34110814 DOI: 10.1021/acs.jmedchem.1c00692  0.585
2021 Wenk D, Ignatchenko V, Macklin A, Hübner H, Gmeiner P, Weikert D, Pischetsrieder M, Kislinger T. Functionally selective activation of the dopamine receptor D is mirrored by the protein expression profiles. Scientific Reports. 11: 3501. PMID 33568753 DOI: 10.1038/s41598-021-83038-x  0.432
2021 Voyer D, Einsiedel J, Gmeiner P, Lévesque D, Rompré PP. Sensitization to amphetamine psychostimulant effect: A key role for ventral tegmental area neurotensin type 2 receptors and MAP kinase pathway. Addiction Biology. e13008. PMID 33491227 DOI: 10.1111/adb.13008  0.441
2021 Ullmann T, Gienger M, Budzinski J, Hellmann J, Hübner H, Gmeiner P, Weikert D. Homobivalent Dopamine D Receptor Ligands Modulate the Dynamic Equilibrium of D Monomers and Homo- and Heterodimers. Acs Chemical Biology. PMID 33435665 DOI: 10.1021/acschembio.0c00895  0.523
2020 Allikalt A, Purkayastha N, Flad K, Schmidt MF, Tabor A, Gmeiner P, Hübner H, Weikert D. Fluorescent ligands for dopamine D/D receptors. Scientific Reports. 10: 21842. PMID 33318558 DOI: 10.1038/s41598-020-78827-9  0.496
2020 Uzuneser TC, Weiss EM, Dahlmanns J, Kalinichenko LS, Amato D, Kornhuber J, Alzheimer C, Hellmann J, Kaindl J, Hübner H, Löber S, Gmeiner P, Grömer TW, Müller CP. Presynaptic vesicular accumulation is required for antipsychotic efficacy in psychotic-like rats. Journal of Psychopharmacology (Oxford, England). 269881120965908. PMID 33274688 DOI: 10.1177/0269881120965908  0.324
2020 Xu X, Kaindl J, Clark MJ, Hübner H, Hirata K, Sunahara RK, Gmeiner P, Kobilka BK, Liu X. Binding pathway determines norepinephrine selectivity for the human βAR over βAR. Cell Research. PMID 33093660 DOI: 10.1038/s41422-020-00424-2  0.358
2020 Willmann M, Ermert J, Prante O, Hübner H, Gmeiner P, Neumaier B. Radiosynthesis and evaluation of F-labeled dopamine D-receptor ligands. Nuclear Medicine and Biology. PMID 32718750 DOI: 10.1016/j.nucmedbio.2020.07.004  0.521
2020 Hellmann J, Drabek M, Yin J, Gunera J, Pröll T, Kraus F, Langmead CJ, Hübner H, Weikert D, Kolb P, Rosenbaum DM, Gmeiner P. Structure-based development of a subtype-selective orexin 1 receptor antagonist. Proceedings of the National Academy of Sciences of the United States of America. PMID 32669442 DOI: 10.1073/Pnas.2002704117  0.411
2020 Klösel I, Schmidt MF, Kaindl J, Hübner H, Weikert D, Gmeiner P. Discovery of Novel Nonpeptidic PAR2 Ligands. Acs Medicinal Chemistry Letters. 11: 1316-1323. PMID 32551018 DOI: 10.1021/acsmedchemlett.0c00154  0.369
2020 Liu X, Kaindl J, Korczynska M, Stößel A, Dengler D, Stanek M, Hübner H, Clark MJ, Mahoney J, Matt RA, Xu X, Hirata K, Shoichet BK, Sunahara RK, Kobilka BK, ... Gmeiner P, et al. An allosteric modulator binds to a conformational hub in the β adrenergic receptor. Nature Chemical Biology. PMID 32483378 DOI: 10.1038/S41589-020-0549-2  0.389
2020 Krüll J, Fehler SK, Hofmann L, Nebel N, Maschauer S, Prante O, Gmeiner P, Lanig H, Hübner H, Heinrich MR. Synthesis, Radiosynthesis and Biological Evaluation of Buprenorphine-Derived Phenylazocarboxamides as Novel μ-Opioid Receptor Ligands. Chemmedchem. 15: 1175-1186. PMID 32378310 DOI: 10.1002/cmdc.202000180  0.435
2020 Yuan D, Liu Z, Kaindl J, Maeda S, Zhao J, Sun X, Xu J, Gmeiner P, Wang HW, Kobilka BK. Activation of the α adrenoceptor by the sedative sympatholytic dexmedetomidine. Nature Chemical Biology. PMID 32152538 DOI: 10.1038/S41589-020-0492-2  0.352
2020 Stolwijk JA, Mildner AK, Kade C, Skiba M, Bernhardt G, Buschauer A, Huebner H, Gmeiner P, Wegener J. Stepwise Dosing Protocol for Increased Throughput in Label-Free Impedance-Based GPCR Assays. Journal of Visualized Experiments : Jove. PMID 32150162 DOI: 10.3791/60686  0.325
2020 Gienger M, Hübner H, Löber S, König B, Gmeiner P. Structure-based development of caged dopamine D/D receptor antagonists. Scientific Reports. 10: 829. PMID 31965029 DOI: 10.1038/S41598-020-57770-9  0.602
2020 Di Pizio A, Waterloo LAW, Brox R, Löber S, Weikert D, Behrens M, Gmeiner P, Niv MY. Rational design of agonists for bitter taste receptor TAS2R14: from modeling to bench and back. Cellular and Molecular Life Sciences : Cmls. 77: 531-542. PMID 31236627 DOI: 10.1007/s00018-019-03194-2  0.408
2019 Plach M, Schäfer T, Borroto-Escuela DO, Weikert D, Gmeiner P, Fuxe K, Friedland K. Differential allosteric modulation within dopamine DR - neurotensin NTS1R and DR - serotonin 5-HTR receptor complexes gives bias to intracellular calcium signalling. Scientific Reports. 9: 16312. PMID 31704949 DOI: 10.1038/S41598-019-52540-8  0.436
2019 Pirzer AS, Lasch R, Friedrich H, Hübner H, Gmeiner P, Heinrich MR. Benzyl Phenylsemicarbazides: A Chemistry-Driven Approach Leading to G Protein-Biased Dopamine D Receptor Agonists with High Subtype Selectivity. Journal of Medicinal Chemistry. 62: 9658-9679. PMID 31613617 DOI: 10.1021/acs.jmedchem.9b01085  0.634
2019 Kling RC, Burchardt C, Einsiedel J, Hübner H, Gmeiner P. Structure-based exploration of an allosteric binding pocket in the NTS1 receptor using bitopic NT(8-13) derivatives and molecular dynamics simulations. Journal of Molecular Modeling. 25: 193. PMID 31209646 DOI: 10.1007/s00894-019-4064-x  0.366
2019 Schwalbe T, Huebner H, Gmeiner P. Development of covalent antagonists for β1- and β2-adrenergic receptors. Bioorganic & Medicinal Chemistry. 27: 2959-2971. PMID 31151791 DOI: 10.1016/j.bmc.2019.05.034  0.389
2019 Xu J, Hu Y, Kaindl J, Risel P, Hübner H, Maeda S, Niu X, Li H, Gmeiner P, Jin C, Kobilka BK. Conformational Complexity and Dynamics in a Muscarinic Receptor Revealed by NMR Spectroscopy. Molecular Cell. PMID 31103421 DOI: 10.1016/J.Molcel.2019.04.028  0.351
2019 Stolwijk JA, Skiba M, Kade C, Bernhardt G, Buschauer A, Hübner H, Gmeiner P, Wegener J. Increasing the throughput of label-free cell assays to study the activation of G-protein-coupled receptors by using a serial agonist exposure protocol. Integrative Biology : Quantitative Biosciences From Nano to Macro. PMID 31083709 DOI: 10.1093/intbio/zyz010  0.34
2019 Stanek M, Picard LP, Schmidt MF, Kaindl JM, Hübner H, Bouvier M, Weikert D, Gmeiner P. Hybridization of β-adrenergic agonists and antagonists confers G protein bias. Journal of Medicinal Chemistry. PMID 31042379 DOI: 10.1021/Acs.Jmedchem.9B00349  0.303
2019 Sommer T, Dlugash G, Hübner H, Gmeiner P, Pischetsrieder M. Monitoring of the dopamine D2 receptor agonists hordenine and N-methyltyramine during the brewing process and in commercial beer samples. Food Chemistry. 276: 745-753. PMID 30409657 DOI: 10.1016/j.foodchem.2018.10.067  0.482
2018 Liu H, Hofmann J, Fish I, Schaake B, Eitel K, Bartuschat A, Kaindl J, Rampp H, Banerjee A, Hübner H, Clark MJ, Vincent SG, Fisher JT, Heinrich MR, Hirata K, ... ... Gmeiner P, et al. Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists. Proceedings of the National Academy of Sciences of the United States of America. PMID 30404914 DOI: 10.1073/Pnas.1813988115  0.313
2017 She X, Pegoli A, Mayr J, Hübner H, Bernhardt G, Gmeiner P, Keller M. Heterodimerization of Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Leads to Increased MR Affinity and Selectivity. Acs Omega. 2: 6741-6754. PMID 30023530 DOI: 10.1021/acsomega.7b01085  0.338
2017 Nebel N, Strauch B, Maschauer S, Lasch R, Rampp H, Fehler SK, Bock LR, Hübner H, Gmeiner P, Heinrich MR, Prante O. [F]Fluorophenylazocarboxylates: Design and Synthesis of Potential Radioligands for Dopamine D3 and μ-Opioid Receptor. Acs Omega. 2: 8649-8659. PMID 29479577 DOI: 10.1021/acsomega.7b01374  0.395
2017 Fish I, Stoessel A, Eitel K, Valant C, Albold S, Hübner H, Möller D, Clark MJ, Sunahara RK, Christopoulos A, Shoichet BK, Gmeiner P. Structure-based design and discovery of new M2 receptor agonists. Journal of Medicinal Chemistry. PMID 29094937 DOI: 10.1021/Acs.Jmedchem.7B01113  0.411
2017 Tabor A, Möller D, Hübner H, Kornhuber J, Gmeiner P. Visualization of ligand-induced dopamine D and D receptor internalization by TIRF microscopy. Scientific Reports. 7: 10894. PMID 28883522 DOI: 10.1038/S41598-017-11436-1  0.498
2017 Männel B, Hübner H, Möller D, Gmeiner P. β-Arrestin biased dopamine D2 receptor partial agonists: Synthesis and pharmacological evaluation. Bioorganic & Medicinal Chemistry. 25: 5613-5628. PMID 28870802 DOI: 10.1016/j.bmc.2017.08.037  0.534
2017 Männel B, Jaiteh M, Zeifman A, Randakova A, Möller D, Hübner H, Gmeiner P, Carlsson J. Structure-Guided Screening for Functionally Selective DDopamine Receptor Ligands from a Virtual Chemical Library. Acs Chemical Biology. 12: 2652-2661. PMID 28846380 DOI: 10.1021/Acschembio.7B00493  0.412
2017 Schwalbe T, Kaindl J, Hübner H, Gmeiner P. Potent haloperidol derivatives covalently binding to the dopamine D2 receptor. Bioorganic & Medicinal Chemistry. 25: 5084-5094. PMID 28666858 DOI: 10.1016/j.bmc.2017.06.034  0.598
2017 Lachmann D, Studte C, Männel B, Hübner H, Gmeiner P, König B. Photochromic Dopamine Receptor Ligands Based on Dithienylethenes and Fulgides. Chemistry (Weinheim An Der Bergstrasse, Germany). 23: 13423-13434. PMID 28650111 DOI: 10.1002/Chem.201702147  0.482
2017 Stößel A, Brox R, Purkayastha N, Hübner H, Hocke C, Prante O, Gmeiner P. Development of molecular tools based on the dopamine D3 receptor ligand FAUC 329 showing inhibiting effects on drug and food maintained behavior. Bioorganic & Medicinal Chemistry. PMID 28495386 DOI: 10.1016/j.bmc.2017.04.036  0.499
2017 Männel B, Dengler D, Shonberg J, Hübner H, Möller D, Gmeiner P. Hydroxy-Substituted Heteroarylpiperazines: Novel Scaffolds for β-Arrestin-Biased DR Agonists. Journal of Medicinal Chemistry. 60: 4693-4713. PMID 28489379 DOI: 10.1021/acs.jmedchem.7b00363  0.456
2017 Pegoli A, She X, Wifling D, Hübner H, Bernhardt G, Gmeiner P, Keller M. Radiolabeled dibenzodiazepinone-type antagonists give evidence of dualsteric binding at the M2 muscarinic acetylcholine receptor. Journal of Medicinal Chemistry. PMID 28388054 DOI: 10.1021/acs.jmedchem.6b01892  0.324
2017 Sommer T, Hübner H, El Kerdawy A, Gmeiner P, Pischetsrieder M, Clark T. Identification of the Beer Component Hordenine as Food-Derived Dopamine D2 Receptor Agonist by Virtual Screening a 3D Compound Database. Scientific Reports. 7: 44201. PMID 28281694 DOI: 10.1038/Srep44201  0.386
2017 Möller D, Banerjee A, Uzuneser TC, Skultety M, Huth T, Plouffe B, Hübner H, Alzheimer C, Friedland K, Müller CP, Bouvier M, Gmeiner P. Discovery of G Protein-Biased Dopaminergics with a Pyrazolo[1,5-a]pyridine Substructure. Journal of Medicinal Chemistry. PMID 28248104 DOI: 10.1021/Acs.Jmedchem.6B01857  0.543
2016 Naporra F, Gobleder S, Wittmann HJ, Spindler J, Bodensteiner M, Bernhardt G, Hübner H, Gmeiner P, Elz S, Strasser A. Dibenzo[b,f][1,4]oxazepines and dibenzo[b,e]oxepines: Influence of the chlorine substitution pattern on the pharmacology at the HR, HR, 5-HTR and other selected GPCRs. Pharmacological Research. 113: 610-625. PMID 27697645 DOI: 10.1016/j.phrs.2016.09.042  0.373
2016 Tabor A, Weisenburger S, Banerjee A, Purkayastha N, Kaindl JM, Hübner H, Wei L, Grömer TW, Kornhuber J, Tschammer N, Birdsall NJ, Mashanov GI, Sandoghdar V, Gmeiner P. Visualization and ligand-induced modulation of dopamine receptor dimerization at the single molecule level. Scientific Reports. 6: 33233. PMID 27615810 DOI: 10.1038/Srep33233  0.809
2016 Manglik A, Lin H, Aryal DK, McCorvy JD, Dengler D, Corder G, Levit A, Kling RC, Bernat V, Hübner H, Huang XP, Sassano MF, Giguère PM, Löber S, Da Duan, ... ... Gmeiner P, et al. Structure-based discovery of opioid analgesics with reduced side effects. Nature. 1-6. PMID 27533032 DOI: 10.1038/Nature19112  0.741
2016 Hübner H, Schellhorn T, Gienger M, Schaab C, Kaindl J, Leeb L, Clark T, Möller D, Gmeiner P. Structure-guided development of heterodimer-selective GPCR ligands. Nature Communications. 7: 12298. PMID 27457610 DOI: 10.1038/Ncomms12298  0.48
2016 Weichert D, Stanek M, Hübner H, Gmeiner P. Structure-guided development of dual β2 adrenergic/dopamine D2 receptor agonists. Bioorganic & Medicinal Chemistry. 24: 2641-53. PMID 27132867 DOI: 10.1016/j.bmc.2016.04.028  0.556
2016 Kling RC, Plomer M, Lang C, Banerjee A, Hübner H, Gmeiner P. Development of Covalent Ligand-Receptor Pairs to Study the Binding Properties of Nonpeptidic Neurotensin Receptor 1 Antagonists. Acs Chemical Biology. PMID 26808719 DOI: 10.1021/acschembio.5b00965  0.445
2016 Kling RC, Clark T, Gmeiner P. Comparative MD Simulations Indicate a Dual Role for Arg1323.50 in Dopamine-Dependent D2R Activation. Plos One. 11: e0146612. PMID 26741139 DOI: 10.1371/Journal.Pone.0146612  0.47
2016 Nebel N, Maschauer S, Hocke C, Hübner H, Gmeiner P, Prante O. Optimization and synthesis of an (18) F-labeled dopamine D3 receptor ligand using [(18) F]fluorophenylazocarboxylic tert-butylester. Journal of Labelled Compounds & Radiopharmaceuticals. 59: 48-53. PMID 26707848 DOI: 10.1002/jlcr.3361  0.491
2015 Möller D, Salama I, Kling RC, Hübner H, Gmeiner P. 1,4-Disubstituted aromatic piperazines with high 5-HT2A/D2 selectivity: Quantitative structure-selectivity investigations, docking, synthesis and biological evaluation. Bioorganic & Medicinal Chemistry. 23: 6195-209. PMID 26299826 DOI: 10.1016/j.bmc.2015.07.050  0.616
2015 Stucchi M, Gmeiner P, Huebner H, Rainoldi G, Sacchetti A, Silvani A, Lesma G. Multicomponent Synthesis and Biological Evaluation of a Piperazine-Based Dopamine Receptor Ligand Library. Acs Medicinal Chemistry Letters. 6: 882-7. PMID 26288260 DOI: 10.1021/acsmedchemlett.5b00131  0.623
2015 Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, et al. Structural insights into µ-opioid receptor activation. Nature. 524: 315-21. PMID 26245379 DOI: 10.1038/Nature14886  0.422
2015 Weichert D, Gmeiner P. Covalent molecular probes for class A G protein-coupled receptors: advances and applications. Acs Chemical Biology. 10: 1376-86. PMID 25860503 DOI: 10.1021/acschembio.5b00070  0.377
2015 Weichert D, Banerjee A, Hiller C, Kling RC, Hübner H, Gmeiner P. Molecular determinants of biased agonism at the dopamine D₂ receptor. Journal of Medicinal Chemistry. 58: 2703-17. PMID 25734236 DOI: 10.1021/jm501889t  0.546
2015 Shonberg J, Kling RC, Gmeiner P, Löber S. GPCR crystal structures: Medicinal chemistry in the pocket. Bioorganic & Medicinal Chemistry. 23: 3880-906. PMID 25638496 DOI: 10.1016/j.bmc.2014.12.034  0.431
2015 Bartuschat AL, Schellhorn T, Hübner H, Gmeiner P, Heinrich MR. Fluoro-substituted phenylazocarboxamides: Dopaminergic behavior and N-arylating properties for irreversible binding. Bioorganic & Medicinal Chemistry. 23: 3938-47. PMID 25564378 DOI: 10.1016/j.bmc.2014.12.012  0.546
2014 Schaab C, Kling RC, Einsiedel J, Hübner H, Clark T, Seebach D, Gmeiner P. Structure-based evolution of subtype-selective neurotensin receptor ligands. Chemistryopen. 3: 206-18. PMID 25478316 DOI: 10.1002/Open.201402031  0.423
2014 Nebel N, Maschauer S, Bartuschat AL, Fehler SK, Hübner H, Gmeiner P, Kuwert T, Heinrich MR, Prante O, Hocke C. Synthesis and evaluation of fluoro substituted pyridinylcarboxamides and their phenylazo analogues for potential dopamine D3 receptor PET imaging. Bioorganic & Medicinal Chemistry Letters. 24: 5399-403. PMID 25453796 DOI: 10.1016/j.bmcl.2014.10.043  0.537
2014 Salama I, Löber S, Hübner H, Gmeiner P. Synthesis and binding profile of haloperidol-based bivalent ligands targeting dopamine D(2)-like receptors. Bioorganic & Medicinal Chemistry Letters. 24: 3753-6. PMID 25047579 DOI: 10.1016/j.bmcl.2014.06.079  0.602
2014 Weichert D, Kruse AC, Manglik A, Hiller C, Zhang C, Hübner H, Kobilka BK, Gmeiner P. Covalent agonists for studying G protein-coupled receptor activation. Proceedings of the National Academy of Sciences of the United States of America. 111: 10744-8. PMID 25006259 DOI: 10.1073/Pnas.1410415111  0.483
2014 Kling RC, Tschammer N, Lanig H, Clark T, Gmeiner P. Active-state model of a dopamine D2 receptor-Gαi complex stabilized by aripiprazole-type partial agonists. Plos One. 9: e100069. PMID 24932547 DOI: 10.1371/Journal.Pone.0100069  0.788
2014 Möller D, Kling RC, Skultety M, Leuner K, Hübner H, Gmeiner P. Functionally selective dopamine D2, D3 receptor partial agonists Journal of Medicinal Chemistry. 57: 4861-4875. PMID 24831693 DOI: 10.1021/jm5004039  0.566
2014 Hocke C, Cumming P, Maschauer S, Kuwert T, Gmeiner P, Prante O. Biodistribution studies of two 18F-labeled pyridinylphenyl amides as subtype selective radioligands for the dopamine D3 receptor. Nuclear Medicine and Biology. 41: 223-8. PMID 24480780 DOI: 10.1016/J.Nucmedbio.2013.12.014  0.376
2014 Fehler SK, Maschauer S, Höfling SB, Bartuschat AL, Tschammer N, Hübner H, Gmeiner P, Prante O, Heinrich MR. Fast and efficient (18) F-labeling by [(18) f]fluorophenylazocarboxylic esters. Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 370-5. PMID 24339325 DOI: 10.1002/chem.201303409  0.611
2014 Lang C, Gmeiner P. ChemInform Abstract: Efficient Synthesis of Heterocyclic Neurotensin Receptor Ligands by Microwave-Assisted Aminocarbonylation. Cheminform. 45: no-no. DOI: 10.1002/CHIN.201405037  0.389
2013 Kruse AC, Ring AM, Manglik A, Hu J, Hu K, Eitel K, Hübner H, Pardon E, Valant C, Sexton PM, Christopoulos A, Felder CC, Gmeiner P, Steyaert J, Weis WI, et al. Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature. 504: 101-6. PMID 24256733 DOI: 10.1038/Nature12735  0.414
2013 Banerjee A, Maschauer S, Hübner H, Gmeiner P, Prante O. Click chemistry based synthesis of dopamine D4 selective receptor ligands for the selection of potential PET tracers. Bioorganic & Medicinal Chemistry Letters. 23: 6079-82. PMID 24100078 DOI: 10.1016/j.bmcl.2013.09.026  0.612
2013 Kruse AC, Weiss DR, Rossi M, Hu J, Hu K, Eitel K, Gmeiner P, Wess J, Kobilka BK, Shoichet BK. Muscarinic receptors as model targets and antitargets for structure-based ligand discovery. Molecular Pharmacology. 84: 528-40. PMID 23887926 DOI: 10.1124/Mol.113.087551  0.41
2013 Jantschak F, Brosda J, Franke RT, Fink H, Möller D, Hübner H, Gmeiner P, Pertz HH. Pharmacological profile of 2-bromoterguride at human dopamine D 2, porcine serotonin 5-hydroxytryptamine 2A, and α 2C-adrenergic receptors, and its antipsychotic-like effects in rats Journal of Pharmacology and Experimental Therapeutics. 347: 57-68. PMID 23863695 DOI: 10.1124/jpet.113.205997  0.554
2013 Kling RC, Lanig H, Clark T, Gmeiner P. Active-state models of ternary GPCR complexes: determinants of selective receptor-G-protein coupling. Plos One. 8: e67244. PMID 23826246 DOI: 10.1371/Journal.Pone.0067244  0.346
2013 Hiller C, Kling RC, Heinemann FW, Meyer K, Hübner H, Gmeiner P. Functionally selective dopamine D2/D3 receptor agonists comprising an enyne moiety. Journal of Medicinal Chemistry. 56: 5130-41. PMID 23730937 DOI: 10.1021/Jm400520C  0.456
2013 Hiller C, Kühhorn J, Gmeiner P. Class A G-protein-coupled receptor (GPCR) dimers and bivalent ligands. Journal of Medicinal Chemistry. 56: 6542-59. PMID 23678887 DOI: 10.1021/jm4004335  0.332
2013 Sanna F, Corda MG, Melis MR, Piludu MA, Löber S, Hübner H, Gmeiner P, Argiolas A, Giorgi O. Dopamine agonist-induced penile erection and yawning: a comparative study in outbred Roman high- and low-avoidance rats. Pharmacology, Biochemistry, and Behavior. 109: 59-66. PMID 23664901 DOI: 10.1016/j.pbb.2013.05.002  0.398
2013 Held C, Hübner H, Kling R, Nagel YA, Wennemers H, Gmeiner P. Impact of the proline residue on ligand binding of neurotensin receptor 2 (NTS2)-selective peptide-peptoid hybrids. Chemmedchem. 8: 772-8. PMID 23532897 DOI: 10.1002/Cmdc.201300054  0.4
2013 Sanna F, Ortner B, Hübner H, Löber S, Tschammer N, Gmeiner P. Discovery of dopamine D₄ receptor antagonists with planar chirality. Bioorganic & Medicinal Chemistry. 21: 1680-4. PMID 23428965 DOI: 10.1016/j.bmc.2013.01.065  0.815
2013 Held C, Plomer M, Hübner H, Meltretter J, Pischetsrieder M, Gmeiner P. Development of a metabolically stable neurotensin receptor 2 (NTS2) ligand. Chemmedchem. 8: 75-81. PMID 23097347 DOI: 10.1002/cmdc.201200376  0.401
2013 Gmeiner P, Lang C. Efficient Synthesis of Heterocyclic Neurotensin Receptor Ligands by Microwave-Assisted Aminocarbonylation Synthesis. 45: 2474-2480. DOI: 10.1055/S-0033-1338497  0.39
2012 Löber S, Hübner H, Buschauer A, Sanna F, Argiolas A, Melis MR, Gmeiner P. Novel azulene derivatives for the treatment of erectile dysfunction. Bioorganic & Medicinal Chemistry Letters. 22: 7151-4. PMID 23099096 DOI: 10.1016/j.bmcl.2012.09.064  0.552
2012 Trincavelli ML, Daniele S, Orlandini E, Navarro G, Casadó V, Giacomelli C, Nencetti S, Nuti E, Macchia M, Huebner H, Gmeiner P, Rossello A, Lluís C, Martini C. A new D₂ dopamine receptor agonist allosterically modulates A(2A) adenosine receptor signalling by interacting with the A(2A)/D₂ receptor heteromer. Cellular Signalling. 24: 951-60. PMID 22230688 DOI: 10.1016/j.cellsig.2011.12.018  0.386
2012 Koschatzky S, Gmeiner P. Selective agonists for dopamine/neurotensin receptor heterodimers. Chemmedchem. 7: 509-14. PMID 22213714 DOI: 10.1002/cmdc.201100499  0.589
2012 Huber D, Löber S, Hübner H, Gmeiner P. Bivalent molecular probes for dopamine D2-like receptors. Bioorganic & Medicinal Chemistry. 20: 455-66. PMID 22100258 DOI: 10.1016/j.bmc.2011.10.063  0.623
2011 Koschatzky S, Tschammer N, Gmeiner P. Cross-receptor interactions between dopamine D2L and neurotensin NTS1 receptors modulate binding affinities of dopaminergics. Acs Chemical Neuroscience. 2: 308-16. PMID 22778874 DOI: 10.1021/cn200020y  0.813
2011 Kügler F, Sihver W, Ermert J, Hübner H, Gmeiner P, Prante O, Coenen HH. Evaluation of 18F-labeled benzodioxine piperazine-based dopamine D4 receptor ligands: lipophilicity as a determinate of nonspecific binding. Journal of Medicinal Chemistry. 54: 8343-52. PMID 22039961 DOI: 10.1021/jm200762g  0.518
2011 Goetz A, Lanig H, Gmeiner P, Clark T. Molecular dynamics simulations of the effect of the G-protein and diffusible ligands on the β2-adrenergic receptor. Journal of Molecular Biology. 414: 611-23. PMID 22037586 DOI: 10.1016/J.Jmb.2011.10.015  0.427
2011 Kühhorn J, Götz A, Hübner H, Thompson D, Whistler J, Gmeiner P. Development of a bivalent dopamine D₂ receptor agonist. Journal of Medicinal Chemistry. 54: 7911-9. PMID 21999579 DOI: 10.1021/Jm2009919  0.625
2011 Sanna F, Succu S, Hübner H, Gmeiner P, Argiolas A, Melis MR. Dopamine D2-like receptor agonists induce penile erection in male rats: differential role of D2, D3 and D4 receptors in the paraventricular nucleus of the hypothalamus. Behavioural Brain Research. 225: 169-76. PMID 21784104 DOI: 10.1016/j.bbr.2011.07.018  0.545
2011 Kühhorn J, Hübner H, Gmeiner P. Bivalent dopamine D2 receptor ligands: synthesis and binding properties. Journal of Medicinal Chemistry. 54: 4896-903. PMID 21599022 DOI: 10.1021/jm2004859  0.542
2011 Pratsch G, Unfried JF, Einsiedel J, Plomer M, Hübner H, Gmeiner P, Heinrich MR. Radical arylation of tyrosine and its application in the synthesis of a highly selective neurotensin receptor 2 ligand. Organic & Biomolecular Chemistry. 9: 3746-52. PMID 21472182 DOI: 10.1039/c1ob05292f  0.426
2011 Einsiedel J, Held C, Hervet M, Plomer M, Tschammer N, Hübner H, Gmeiner P. Discovery of highly potent and neurotensin receptor 2 selective neurotensin mimetics. Journal of Medicinal Chemistry. 54: 2915-23. PMID 21446649 DOI: 10.1021/jm200006c  0.746
2011 Tschammer N, Elsner J, Goetz A, Ehrlich K, Schuster S, Ruberg M, Kühhorn J, Thompson D, Whistler J, Hübner H, Gmeiner P. Highly potent 5-aminotetrahydropyrazolopyridines: enantioselective dopamine D3 receptor binding, functional selectivity, and analysis of receptor-ligand interactions. Journal of Medicinal Chemistry. 54: 2477-91. PMID 21388142 DOI: 10.1021/Jm101639T  0.818
2011 Löber S, Hübner H, Tschammer N, Gmeiner P. Recent advances in the search for D3- and D4-selective drugs: probes, models and candidates. Trends in Pharmacological Sciences. 32: 148-57. PMID 21232805 DOI: 10.1016/j.tips.2010.12.003  0.786
2011 Rosenbaum DM, Zhang C, Lyons JA, Holl R, Aragao D, Arlow DH, Rasmussen SG, Choi HJ, Devree BT, Sunahara RK, Chae PS, Gellman SH, Dror RO, Shaw DE, Weis WI, ... ... Gmeiner P, et al. Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature. 469: 236-40. PMID 21228876 DOI: 10.1038/Nature09665  0.404
2011 Tschammer N, Bollinger S, Kenakin T, Gmeiner P. Histidine 6.55 is a major determinant of ligand-biased signaling in dopamine D2L receptor. Molecular Pharmacology. 79: 575-85. PMID 21163968 DOI: 10.1124/mol.110.068106  0.783
2010 Tschammer N, Dörfler M, Hübner H, Gmeiner P. Engineering a GPCR-ligand pair that simulates the activation of D(2L) by Dopamine. Acs Chemical Neuroscience. 1: 25-35. PMID 22778805 DOI: 10.1021/cn900001b  0.807
2010 Ortega R, Hübner H, Gmeiner P, Masaguer CF. Aromatic ring functionalization of benzolactam derivatives: new potent dopamine D3 receptor ligands. Bioorganic & Medicinal Chemistry Letters. 21: 2670-4. PMID 21273071 DOI: 10.1016/j.bmcl.2010.12.083  0.645
2010 Höfling SB, Maschauer S, Hübner H, Gmeiner P, Wester HJ, Prante O, Heinrich MR. Synthesis, biological evaluation and radiolabelling by 18F-fluoroarylation of a dopamine D3-selective ligand as prospective imaging probe for PET. Bioorganic & Medicinal Chemistry Letters. 20: 6933-7. PMID 21030255 DOI: 10.1016/j.bmcl.2010.09.142  0.374
2010 Bollinger S, Hübner H, Heinemann FW, Meyer K, Gmeiner P. Novel pyridylmethylamines as highly selective 5-HT(1A) superagonists. Journal of Medicinal Chemistry. 53: 7167-79. PMID 20860381 DOI: 10.1021/Jm100835Q  0.311
2010 Skultety M, Hübner H, Löber S, Gmeiner P. Bioisosteric replacement leading to biologically active [2.2]paracyclophanes with altered binding profiles for aminergic G-protein-coupled receptors. Journal of Medicinal Chemistry. 53: 7219-28. PMID 20839776 DOI: 10.1021/jm100899z  0.508
2010 Hocke C, Maschauer S, Hübner H, Löber S, Utz W, Kuwert T, Gmeiner P, Prante O. A series of 18F-labelled pyridinylphenyl amides as subtype-selective radioligands for the dopamine D3 receptor. Chemmedchem. 5: 941-8. PMID 20408162 DOI: 10.1002/cmdc.201000067  0.449
2010 Loeber S, Huebner H, Gmeiner P. ChemInform Abstract: Fused Azaindole Derivatives: Molecular Design, Synthesis and in vitro Pharmacology Leading to the Preferential Dopamine D3 Receptor Agonist FAUC 725. Cheminform. 33: no-no. DOI: 10.1002/CHIN.200251155  0.548
2010 Bergauer M, Huebner H, Gmeiner P. ChemInform Abstract: 2,4-Disubstituted Pyrroles: Synthesis, Traceless Linking and Pharmacological Investigations Leading to the Dopamine D4 Receptor Partial Agonist FAUC 356. Cheminform. 33: no-no. DOI: 10.1002/CHIN.200243195  0.579
2010 Loeber S, Aboul-Fadl T, Huebner H, Gmeiner P. ChemInform Abstract: Di- and Trisubstituted Pyrazolo[1,5-a]pyridine Derivatives: Synthesis, Dopamine Receptor Binding and Ligand Efficacy. Cheminform. 33: no-no. DOI: 10.1002/CHIN.200225139  0.5
2010 Lehmann T, Huebner H, Gmeiner P. ChemInform Abstract: Dopaminergic 7-Aminotetrahydroindolizines: Ex-Chiral Pool Synthesis and Preferential D3 Receptor Binding. Cheminform. 33: no-no. DOI: 10.1002/CHIN.200208149  0.547
2010 Einsiedel J, Huebner H, Gmeiner P. ChemInform Abstract: Benzamide Bioisosteres Incorporating Dihydroheteroazole Substructures: EPC Synthesis and SAR Leading to a Selective Dopamine D4 Receptor Partial Agonist (FAUC 179). Cheminform. 33: no-no. DOI: 10.1002/CHIN.200205152  0.585
2010 Ortner B, Waibel R, Gmeiner P. ChemInform Abstract: Indoloparacyclophanes: Synthesis and Dopamine Receptor Binding of a Novel Arylbioisostere. Cheminform. 32: no-no. DOI: 10.1002/CHIN.200129126  0.485
2010 Haubmann C, Huebner H, Gmeiner P. ChemInform Abstract: Piperidinylpyrroles: Design, Synthesis, and Binding Properties of Novel and Selective Dopamine D4 Receptor Ligands. Cheminform. 31: no-no. DOI: 10.1002/CHIN.200008156  0.582
2010 Haubmann C, Huebner H, Gmeiner P. ChemInform Abstract: 2,2-Dicyanovinyl as a Nonaromatic Aryl Bioisostere: Synthesis, Binding Experiments, and SAR Studies of Highly Selective Dopamine D4 Receptor Ligands. Cheminform. 30: no-no. DOI: 10.1002/CHIN.199943280  0.598
2010 Thomas C, Huebner H, Gmeiner P. ChemInform Abstract: Enantio- and Diastereocontrolled Dopamine D1, D2, D3, and D4 Receptor Binding of N-(3-Pyrrolidinylmethyl)benzamides Synthesized from Aspartic Acid. Cheminform. 30: no-no. DOI: 10.1002/CHIN.199926215  0.518
2010 Loeber S, Huebner H, Gmeiner P. ChemInform Abstract: Azaindole Derivatives with High Affinity for the Dopamine D4 Receptor: Synthesis, Ligand Binding Studies and Comparison of Molecular Electrostatic Potential Maps. Cheminform. 30: no-no. DOI: 10.1002/CHIN.199919161  0.552
2010 GMEINER P, BOLLINGER B, LOTTER H. ChemInform Abstract: Synthesis and Stereochemistry of Oxazolo(4′,5′:1,2)benz(5,4,3-c,d) indole Derivatives as Intermediates on the Way to a Selective Dopamine Autoreceptor Agonist. Cheminform. 27: no-no. DOI: 10.1002/CHIN.199641118  0.457
2010 GMEINER P, KAERTNER A, MIERAU J. ChemInform Abstract: Synthesis and Dopamine Receptor Binding Studies of Homochiral 8- Aminopyrido(1,2-a)indoles. Cheminform. 26: no-no. DOI: 10.1002/CHIN.199551185  0.484
2010 GMEINER P, BOLLINGER B, MIERAU J, HOEFNER G. ChemInform Abstract: Synthesis, Pharmacological Investigation and Computational Studies on a Tricyclic Ergoline Analogue with Selective Dopamine Autoreceptor Activity. Cheminform. 26: no-no. DOI: 10.1002/CHIN.199551129  0.327
2010 GMEINER P, SOMMER J, HOEFNER G. ChemInform Abstract: Synthesis and Dopamine Receptor Binding of 3-Phenylazepino(5,4,3-c,d) indole Derivatives. Cheminform. 26: no-no. DOI: 10.1002/CHIN.199536194  0.554
2010 GMEINER P, SOMMER J, MIERAU J, HOEFNER G. ChemInform Abstract: Dopamine Autoreceptor Agonists: Computational Studies, Synthesis and Biological Investigations. Cheminform. 26: no-no. DOI: 10.1002/CHIN.199507160  0.337
2010 GMEINER P, SOMMER J. ChemInform Abstract: Selective Dopamine D-2 Autoreceptor Agonists with 8-Azaindole Substructure: Synthesis and Theoretical Investigations. Cheminform. 25: no-no. DOI: 10.1002/CHIN.199448167  0.497
2009 Huber D, Hübner H, Gmeiner P. 1,1'-Disubstituted ferrocenes as molecular hinges in mono- and bivalent dopamine receptor ligands. Journal of Medicinal Chemistry. 52: 6860-70. PMID 19807103 DOI: 10.1021/jm901120h  0.621
2009 Ehrlich K, Götz A, Bollinger S, Tschammer N, Bettinetti L, Härterich S, Hübner H, Lanig H, Gmeiner P. Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding. Journal of Medicinal Chemistry. 52: 4923-35. PMID 19606869 DOI: 10.1021/jm900690y  0.786
2009 Loaiza PR, Löber S, Hübner H, Gmeiner P. Parallel synthesis of potent dopaminergic N-phenyltriazole carboxamides applying a novel click chemistry based phenol linker. Bioorganic & Medicinal Chemistry. 17: 5482-7. PMID 19592258 DOI: 10.1016/j.bmc.2009.06.041  0.416
2009 Linz S, Müller J, Hübner H, Gmeiner P, Troschütz R. Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases. Bioorganic & Medicinal Chemistry. 17: 4448-58. PMID 19481941 DOI: 10.1016/j.bmc.2009.05.015  0.532
2009 Löber S, Tschammer N, Hübner H, Melis MR, Argiolas A, Gmeiner P. The azulene framework as a novel arene bioisostere: design of potent dopamine D4 receptor ligands inducing penile erection. Chemmedchem. 4: 325-8. PMID 19185034 DOI: 10.1002/cmdc.200800395  0.808
2008 Dörfler M, Tschammer N, Hamperl K, Hübner H, Gmeiner P. Novel D3 selective dopaminergics incorporating enyne units as nonaromatic catechol bioisosteres: synthesis, bioactivity, and mutagenesis studies. Journal of Medicinal Chemistry. 51: 6829-38. PMID 18834111 DOI: 10.1021/jm800895v  0.8
2008 Härterich S, Koschatzky S, Einsiedel J, Gmeiner P. Novel insights into GPCR-peptide interactions: mutations in extracellular loop 1, ligand backbone methylations and molecular modeling of neurotensin receptor 1. Bioorganic & Medicinal Chemistry. 16: 9359-68. PMID 18809332 DOI: 10.1016/j.bmc.2008.08.051  0.417
2008 Prante O, Tietze R, Hocke C, Löber S, Hübner H, Kuwert T, Gmeiner P. Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET. Journal of Medicinal Chemistry. 51: 1800-10. PMID 18307287 DOI: 10.1021/jm701375u  0.457
2008 Hocke C, Prante O, Salama I, Hübner H, Löber S, Kuwert T, Gmeiner P. 18F-Labeled FAUC 346 and BP 897 derivatives as subtype-selective potential PET radioligands for the dopamine D3 receptor. Chemmedchem. 3: 788-93. PMID 18306190 DOI: 10.1002/cmdc.200700327  0.528
2008 Einsiedel J, Hübner H, Hervet M, Härterich S, Koschatzky S, Gmeiner P. Peptide backbone modifications on the C-terminal hexapeptide of neurotensin. Bioorganic & Medicinal Chemistry Letters. 18: 2013-8. PMID 18276136 DOI: 10.1016/j.bmcl.2008.01.110  0.315
2008 Tietze R, Löber S, Hübner H, Gmeiner P, Kuwert T, Prante O. Discovery of a dopamine D4 selective PET ligand candidate taking advantage of a click chemistry based REM linker. Bioorganic & Medicinal Chemistry Letters. 18: 983-8. PMID 18164618 DOI: 10.1016/j.bmcl.2007.12.026  0.424
2007 Görnemann T, Hübner H, Gmeiner P, Horowski R, Latté KP, Flieger M, Pertz HH. Characterization of the molecular fragment that is responsible for agonism of pergolide at serotonin 5-Hydroxytryptamine2B and 5-Hydroxytryptamine2A receptors. The Journal of Pharmacology and Experimental Therapeutics. 324: 1136-45. PMID 18096760 DOI: 10.1124/jpet.107.133165  0.338
2007 Rodriguez Loaiza P, Löber S, Hübner H, Gmeiner P. Click chemistry based solid phase supported synthesis of dopaminergic phenylacetylenes. Bioorganic & Medicinal Chemistry. 15: 7248-57. PMID 17827018 DOI: 10.1016/J.BMC.2007.08.038  0.485
2007 Stark D, Piel M, Hübner H, Gmeiner P, Gründer G, Rösch F. In vitro affinities of various halogenated benzamide derivatives as potential radioligands for non-invasive quantification of D(2)-like dopamine receptors. Bioorganic & Medicinal Chemistry. 15: 6819-29. PMID 17765546 DOI: 10.1016/j.bmc.2007.07.017  0.537
2007 Boeckler F, Gmeiner P. Dopamine D3 receptor ligands: recent advances in the control of subtype selectivity and intrinsic activity. Biochimica Et Biophysica Acta. 1768: 871-887. PMID 17274946 DOI: 10.1016/J.Bbamem.2006.12.001  0.839
2007 Salama I, Hocke C, Utz W, Prante O, Boeckler F, Hübner H, Kuwert T, Gmeiner P. Structure-selectivity investigations of D2-like receptor ligands by CoMFA and CoMSIA guiding the discovery of D3 selective PET radioligands. Journal of Medicinal Chemistry. 50: 489-500. PMID 17266201 DOI: 10.1021/Jm0611152  0.821
2007 Gmeiner P. Laboratory Automation with Parallel Synthesis: A Solid Phase Supported Access to New Biogenic Amine Receptor Ligands Cheminform. 38. DOI: 10.1002/CHIN.200747238  0.315
2006 Melis MR, Succu S, Sanna F, Melis T, Mascia MS, Enguehard-Gueiffier C, Hubner H, Gmeiner P, Gueiffier A, Argiolas A. PIP3EA and PD-168077, two selective dopamine D4 receptor agonists, induce penile erection in male rats: site and mechanism of action in the brain. The European Journal of Neuroscience. 24: 2021-30. PMID 17067298 DOI: 10.1111/j.1460-9568.2006.05043.x  0.445
2006 Boeckler F, Gmeiner P. The structural evolution of dopamine D3 receptor ligands: structure-activity relationships and selected neuropharmacological aspects. Pharmacology & Therapeutics. 112: 281-333. PMID 16905195 DOI: 10.1016/J.Pharmthera.2006.04.007  0.826
2006 Enguehard-Gueiffier C, Hübner H, El Hakmaoui A, Allouchi H, Gmeiner P, Argiolas A, Melis MR, Gueiffier A. 2-[(4-phenylpiperazin-1-yl)methyl]imidazo(di)azines as selective D4-ligands. Induction of penile erection by 2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo[1,2-a]pyridine (PIP3EA), a potent and selective D4 partial agonist. Journal of Medicinal Chemistry. 49: 3938-47. PMID 16789750 DOI: 10.1021/jm060166w  0.596
2006 Schlotter K, Boeckler F, Hübner H, Gmeiner P. Fancy bioisosteres: novel paracyclophane derivatives as super-affinity dopamine D3 receptor antagonists. Journal of Medicinal Chemistry. 49: 3628-3635. PMID 16759104 DOI: 10.1021/Jm060138D  0.833
2006 Salama I, Schlotter K, Utz W, Hübner H, Gmeiner P, Boeckler F. CoMFA and CoMSIA investigations of dopamine D3 receptor ligands leading to the prediction, synthesis, and evaluation of rigidized FAUC 365 analogues. Bioorganic & Medicinal Chemistry. 14: 5898-912. PMID 16750374 DOI: 10.1016/J.Bmc.2006.05.025  0.852
2006 Seeman P, Wilson A, Gmeiner P, Kapur S. Dopamine D2 and D3 receptors in human putamen, caudate nucleus, and globus pallidus. Synapse (New York, N.Y.). 60: 205-11. PMID 16739118 DOI: 10.1002/SYN.20298  0.56
2006 Löber S, Hübner H, Gmeiner P. Synthesis and biological investigations of dopaminergic partial agonists preferentially recognizing the D4 receptor subtype. Bioorganic & Medicinal Chemistry Letters. 16: 2955-9. PMID 16563764 DOI: 10.1016/J.BMCL.2006.02.075  0.638
2006 Loaiza PR, Löber S, Hübner H, Gmeiner P. Click chemistry on solid phase: parallel synthesis of N-benzyltriazole carboxamides as super-potent G-protein coupled receptor ligands. Journal of Combinatorial Chemistry. 8: 252-61. PMID 16529521 DOI: 10.1021/CC050127Q  0.362
2006 Prante O, Hocke C, Löber S, Hübner H, Gmeiner P, Kuwert T. Tissue distribution of radioiodinated FAUC113: assessment of a pyrazolo(1,5-a) pyridine based dopamine D4 receptor radioligand candidate. Nuklearmedizin. Nuclear Medicine. 45: 41-8. PMID 16493513 DOI: 10.1267/NUKL06010041  0.514
2006 Elsner J, Boeckler F, Davidson K, Sugden D, Gmeiner P. Bicyclic melatonin receptor agonists containing a ring-junction nitrogen: Synthesis, biological evaluation, and molecular modeling of the putative bioactive conformation. Bioorganic & Medicinal Chemistry. 14: 1949-1958. PMID 16290939 DOI: 10.1016/J.Bmc.2005.10.042  0.782
2006 Bettinetti L, Löber S, Hübner H, Gmeiner P. Parallel synthesis and biological screening of dopamine receptor ligands taking advantage of a click chemistry based BAL linker. Journal of Combinatorial Chemistry. 7: 309-16. PMID 15762761 DOI: 10.1021/CC049860S  0.568
2006 Hocke C, Löber S, Hübner H, Gmeiner P, Kuwert T, Prante O. Tissue distribution of radioiodinated FAUC113 Nuklearmedizin. 45: 41-48. DOI: 10.1055/s-0038-1623933  0.342
2006 Tietze R, Hocke C, Löber S, Hübner H, Kuwert T, Gmeiner P, Prante O. Syntheses and radiofluorination of two derivatives of 5-cyano-indole as selective ligands for the dopamine subtype-4 receptor Journal of Labelled Compounds and Radiopharmaceuticals. 49: 55-70. DOI: 10.1002/JLCR.1026  0.521
2006 Loeber S, Huebner H, Gmeiner P. Synthesis and Biological Investigations of Dopaminergic Partial Agonists Preferentially Recognizing the D4 Receptor Subtype. Cheminform. 37. DOI: 10.1002/CHIN.200635114  0.574
2005 Hocke C, Prante O, Löber S, Hübner H, Gmeiner P, Kuwert T. Synthesis and evaluation of 18F-labeled dopamine D3 receptor ligands as potential PET imaging agents. Bioorganic & Medicinal Chemistry Letters. 15: 4819-23. PMID 16139501 DOI: 10.1016/J.BMCL.2005.07.037  0.502
2005 Elsner J, Boeckler F, Heinemann FW, Hübner H, Gmeiner P. Pharmacophore-Guided Drug Discovery Investigations Leading to Bioactive 5-Aminotetrahydropyrazolopyridines. Implications for the Binding Mode of Heterocyclic Dopamine D3 Receptor Agonists§ Journal of Medicinal Chemistry. 48: 5771-5779. PMID 16134944 DOI: 10.1021/Jm0503805  0.839
2005 Bettinetti L, Hübner H, Gmeiner P. Chirospecific and subtype selective dopamine receptor binding of heterocyclic methoxynaphthamide analogs. Archiv Der Pharmazie. 338: 276-80. PMID 15952242 DOI: 10.1002/ARDP.200400997  0.403
2005 Schlotter K, Boeckler F, Hübner H, Gmeiner P. Fancy bioisosteres: metallocene-derived G-protein-coupled receptor ligands with subnanomolar binding affinity and novel selectivity profiles. Journal of Medicinal Chemistry. 48: 3696-3699. PMID 15916420 DOI: 10.1021/Jm050170S  0.841
2005 Lenz C, Boeckler F, Hübner H, Gmeiner P. Fancy bioisosteres: Synthesis, SAR, and pharmacological investigations of novel nonaromatic dopamine D3 receptor ligands Bioorganic & Medicinal Chemistry. 13: 4434-4442. PMID 15908220 DOI: 10.1016/J.Bmc.2005.04.047  0.831
2005 Boeckler F, Ohnmacht U, Lehmann T, Utz W, Hübner H, Gmeiner P. CoMFA and CoMSIA investigations revealing novel insights into the binding modes of dopamine D3 receptor agonists. Journal of Medicinal Chemistry. 48: 2493-508. PMID 15801839 DOI: 10.1021/jm049269  0.851
2005 Boeckler F, Lanig H, Gmeiner P. Modeling the similarity and divergence of dopamine D2-like receptors and identification of validated ligand-receptor complexes. Journal of Medicinal Chemistry. 48: 694-709. PMID 15689154 DOI: 10.1021/Jm049612A  0.842
2005 Lenz C, Haubmann C, Hübner H, Boeckler F, Gmeiner P. Fancy bioisosteres: synthesis and dopaminergic properties of the endiyne FAUC 88 as a novel non-aromatic D3 agonist. Bioorganic & Medicinal Chemistry. 13: 185-191. PMID 15582463 DOI: 10.1016/J.Bmc.2004.09.044  0.834
2005 Hocke C, Prante O, Löber S, Hübner H, Gmeiner P, Kuwert T. Synthesis and radioiodination of selective ligands for the dopamine D3 receptor subtype. Bioorganic & Medicinal Chemistry Letters. 14: 3963-6. PMID 15225707 DOI: 10.1016/J.BMCL.2004.05.052  0.629
2004 Bittermann H, Einsiedel J, Hübner H, Gmeiner P. Evaluation of lactam-bridged neurotensin analogues adjusting psi(Pro10) close to the experimentally derived bioactive conformation of NT(8-13). Journal of Medicinal Chemistry. 47: 5587-90. PMID 15481995 DOI: 10.1021/JM049644Y  0.354
2004 Kortagere S, Gmeiner P, Weinstein H, Schetz JA. Certain 1,4-disubstituted aromatic piperidines and piperazines with extreme selectivity for the dopamine D4 receptor interact with a common receptor microdomain. Molecular Pharmacology. 66: 1491-9. PMID 15448188 DOI: 10.1124/Mol.104.001321  0.561
2004 Hussenether T, Hübner H, Gmeiner P, Troschütz R. Clozapine derived 2,3-dihydro-1H-1,4- and 1,5-benzodiazepines with D4 receptor selectivity: synthesis and biological testing. Bioorganic & Medicinal Chemistry. 12: 2625-37. PMID 15110844 DOI: 10.1016/J.BMC.2004.03.023  0.516
2004 Boeckler F, Russig H, Zhang W, Löber S, Schetz J, Hübner H, Ferger B, Gmeiner P, Feldon J. FAUC 213, a highly selective dopamine D4 receptor full antagonist, exhibits atypical antipsychotic properties in behavioural and neurochemical models of schizophrenia. Psychopharmacology. 175: 7-17. PMID 15007532 DOI: 10.1007/S00213-004-1782-1  0.822
2004 Lenz C, Boeckler F, Hübner H, Gmeiner P. Analogues of FAUC 73 revealing new insights into the structural requirements of nonaromatic dopamine D3 receptor agonists Bioorganic & Medicinal Chemistry. 12: 113-117. PMID 14697776 DOI: 10.1016/J.Bmc.2003.10.011  0.826
2004 Einsiedel J, Weber K, Thomas C, Lehmann T, Hübner H, Gmeiner P. Stereocontrolled dopamine receptor binding and subtype selectivity of clebopride analogues synthesized from aspartic acid. Bioorganic & Medicinal Chemistry Letters. 13: 3293-6. PMID 12951112 DOI: 10.1016/S0960-894X(03)00678-4  0.578
2004 Einsiedel J, Weber K, Thomas C, Lehmann T, Huebner H, Gmeiner P. Stereocontrolled Dopamine Receptor Binding and Subtype Selectivity of Clebopride Analogues Synthesized from Aspartic Acid. Cheminform. 35. DOI: 10.1002/CHIN.200401169  0.483
2003 Boeckler F, Leng A, Mura A, Bettinetti L, Feldon J, Gmeiner P, Ferger B. Attenuation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity by the novel selective dopamine D3-receptor partial agonist FAUC 329 predominantly in the nucleus accumbens of mice. Biochemical Pharmacology. 66: 1025-32. PMID 12963489 DOI: 10.1016/S0006-2952(03)00451-9  0.781
2003 Löber S, Rodriguez-Loaiza P, Gmeiner P. Click linker: efficient and high-yielding synthesis of a new family of SPOS resins by 1,3-dipolar cycloaddition. Organic Letters. 5: 1753-5. PMID 12735769 DOI: 10.1021/OL034520L  0.372
2003 Einsiedel J, Hübner H, Gmeiner P. Cyclic amidines as benzamide bioisosteres: EPC synthesis and SAR studies leading to the selective dopamine D4 receptor agonist FAUC 312. Bioorganic & Medicinal Chemistry Letters. 13: 851-4. PMID 12617906 DOI: 10.1016/S0960-894X(03)00004-0  0.621
2003 Löber S, Hübner H, Gmeiner P. Fused azaindole derivatives: molecular design, synthesis and in vitro pharmacology leading to the preferential dopamine D3 receptor agonist FAUC 725. Bioorganic & Medicinal Chemistry Letters. 12: 2377-80. PMID 12161137 DOI: 10.1016/S0960-894X(02)00390-6  0.581
2003 Bergauer M, Hübner H, Gmeiner P. 2,4-Disubstituted pyrroles: synthesis, traceless linking and pharmacological investigations leading to the dopamine D4 receptor partial agonist FAUC 356. Bioorganic & Medicinal Chemistry Letters. 12: 1937-40. PMID 12113813 DOI: 10.1016/S0960-894X(02)00316-5  0.569
2003 Moll A, Hübner H, Gmeiner P, Troschütz R. Phenylpiperazinylmethylindolecarboxylates and derivatives as selective D(4)-ligands. Bioorganic & Medicinal Chemistry. 10: 1671-9. PMID 11937325 DOI: 10.1016/S0968-0896(02)00042-1  0.62
2003 Löber S, Aboul-Fadl T, Hübner H, Gmeiner P. Di- and trisubstituted pyrazolo[1,5-a]pyridine derivatives: synthesis, dopamine receptor binding and ligand efficacy. Bioorganic & Medicinal Chemistry Letters. 12: 633-6. PMID 11844688 DOI: 10.1016/S0960-894X(01)00814-9  0.561
2003 M. El-Abadelah M, Gmeiner P, Hübner H, A. Abu Safieh K, I. Fasfous I, S. Sabri S, Voelter W. Synthesis and Dopamine Receptor Binding of Some Pyrazolo[3’,4’:6,7]azepino[5,4,3-cd]indoles Heterocycles. 60: 1339. DOI: 10.3987/COM-03-9734  0.393
2003 Heindl C, Hübner H, Gmeiner P. Enantiospecific synthesis and receptor binding of novel dopamine receptor ligands employing natural 4-hydroxyproline as a practical and flexible building block Tetrahedron: Asymmetry. 14: 3153-3172. DOI: 10.1016/J.TETASY.2003.08.020  0.505
2003 Heindl C, Hübner H, Gmeiner P. Ex-chiral pool synthesis and receptor binding studies of 4-substituted prolinol derivatives Tetrahedron: Asymmetry. 14: 3141-3152. DOI: 10.1016/J.TETASY.2003.08.019  0.398
2003 Einsiedel J, Huebner H, Gmeiner P. Cyclic Amidines as Benzamide Bioisosteres: EPC Synthesis and SAR Studies Leading to the Selective Dopamine D4 Receptor Agonist FAUC 312. Cheminform. 34. DOI: 10.1002/CHIN.200330180  0.592
2002 Bettinetti L, Schlotter K, Hübner H, Gmeiner P. Interactive SAR studies: rational discovery of super-potent and highly selective dopamine D3 receptor antagonists and partial agonists. Journal of Medicinal Chemistry. 45: 4594-7. PMID 12361386 DOI: 10.1021/JM025558R  0.608
2002 Einsiedel J, Hübner H, Gmeiner P. Benzamide bioisosteres incorporating dihydroheteroazole substructures: EPC synthesis and SAR leading to a selective dopamine D4 receptor partial agonist (FAUC 179). Bioorganic & Medicinal Chemistry Letters. 11: 2533-6. PMID 11549463 DOI: 10.1016/S0960-894X(01)00484-X  0.573
2002 Löber S, Ortner B, Bettinetti L, Hübner H, Gmeiner P. Analogs of the dopamine D4 receptor ligand FAUC 113 with planar- and central-chirality Tetrahedron: Asymmetry. 13: 2303-2310. DOI: 10.1016/S0957-4166(02)00639-0  0.587
2001 Lehmann T, Hübner H, Gmeiner P. Dopaminergic 7-aminotetrahydroindolizines: ex-chiral pool synthesis and preferential D3 receptor binding Bioorganic &Amp; Medicinal Chemistry Letters. 11: 2863-2866. PMID 11597417 DOI: 10.1016/S0960-894X(01)00564-9  0.534
2001 Löber S, Hübner H, Utz W, Gmeiner P. Rationally based efficacy tuning of selective dopamine d4 receptor ligands leading to the complete antagonist 2-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 213). Journal of Medicinal Chemistry. 44: 2691-4. PMID 11495580 DOI: 10.1021/JM015522J  0.594
2001 Lanig H, Utz W, Gmeiner P. Comparative molecular field analysis of dopamine D4 receptor antagonists including 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 113), 3-[4-(4-chlorophenyl)piperazin-1-ylmethyl]-1H-pyrrolo-[2,3-b]pyridine (L-745,870), and clozapine. Journal of Medicinal Chemistry. 44: 1151-7. PMID 11312915 DOI: 10.1021/JM001055E  0.491
2001 Ortner B, Waibel R, Gmeiner P. Indoloparacyclophanes: Synthesis and Dopamine Receptor Binding of a Novel Arylbioisostere This work was supported by the Fonds der Chemischen Industrie. Angewandte Chemie (International Ed. in English). 40: 1283-1285. PMID 11301452 DOI: 10.1002/1521-3773(20010401)40:7<1283::aid-anie1283>3.0.co;2-#  0.422
2001 Einsiedel J, Thomas C, Hübner H, Gmeiner P. Phenyloxazoles and phenylthiazoles as benzamide bioisosteres: synthesis and dopamine receptor binding profiles. Bioorganic & Medicinal Chemistry Letters. 10: 2041-4. PMID 10987445 DOI: 10.1016/S0960-894X(00)00405-4  0.543
2001 Prante O, Löber S, Hübner H, Gmeiner P, Kuwert T. Synthesis and in vitro evaluation of iodine labelled pyrazolo[1,5-a]pyridines as highly selective dopamine D4 receptor ligands Journal of Labelled Compounds and Radiopharmaceuticals. 44: 849-858. DOI: 10.1002/JLCR.508  0.573
2001 Ortner B, Waibel R, Gmeiner P. Indoloparacyclophanes: Synthesis and Dopamine Receptor Binding of a Novel Arylbioisostere Angewandte Chemie. 113: 1323-1325. DOI: 10.1002/1521-3757(20010401)113:7<1323::AID-ANGE1323>3.0.CO;2-I  0.489
2000 Hübner H, Kraxner J, Gmeiner P. Cyanoindole derivatives as highly selective dopamine D(4) receptor partial agonists: solid-phase synthesis, binding assays, and functional experiments. Journal of Medicinal Chemistry. 43: 4563-9. PMID 11087581 DOI: 10.1021/JM0009989  0.584
2000 Weber K, Ohnmacht U, Gmeiner P. Enantiopure 4- and 5-aminopiperidin-2-ones: regiocontrolled synthesis and conformational characterization as bioactive beta-turn mimetics. The Journal of Organic Chemistry. 65: 7406-16. PMID 11076597 DOI: 10.1021/JO000555C  0.335
2000 Kraxner J, Hübner H, Gmeiner P. Azepino- and diazepinoindoles: synthesis and dopamine receptor binding profiles. Archiv Der Pharmazie. 333: 287-92. PMID 11039184 DOI: 10.1002/1521-4184(20009)333:9<287::AID-ARDP287>3.0.CO;2-R  0.575
2000 Hübner H, Haubmann C, Utz W, Gmeiner P. Conjugated enynes as nonaromatic catechol bioisosteres: synthesis, binding experiments, and computational studies of novel dopamine receptor agonists recognizing preferentially the D(3) subtype. Journal of Medicinal Chemistry. 43: 756-62. PMID 10691700 DOI: 10.1021/JM991098Z  0.621
2000 Kraxner J, Huebner H, Gmeiner P. ChemInform Abstract: Azepino- and Diazepinoindoles: Synthesis and Dopamine Receptor Binding Profiles. Cheminform. 31: no-no. DOI: 10.1002/CHIN.200052143  0.48
2000 Einsiedel J, Thomas C, Huebner H, Gmeiner P. ChemInform Abstract: Phenyloxazoles and Phenylthiazoles as Benzamide Bioisosteres: Synthesis and Dopamine Receptor Binding Profiles. Cheminform. 31: no-no. DOI: 10.1002/CHIN.200047233  0.482
1999 Haubmann C, Hübner H, Gmeiner P. Piperidinylpyrroles: design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands. Bioorganic & Medicinal Chemistry Letters. 9: 3143-6. PMID 10560741 DOI: 10.1016/S0960-894X(99)00540-5  0.572
1999 Haubmann C, Hübner H, Gmeiner P. 2,2-Dicyanovinyl as a nonaromatic aryl bioisostere: synthesis, binding experiments and SAR studies of highly selective dopamine D4 receptor ligands. Bioorganic & Medicinal Chemistry Letters. 9: 1969-72. PMID 10450964 DOI: 10.1016/S0960-894X(99)00302-9  0.623
1999 Thomas C, Hübner H, Gmeiner P. Enantio- and diastereocontrolled dopamine D1, D2, D3 and D4 receptor binding of N-(3-pyrrolidinylmethyl)benzamides synthesized from aspartic acid. Bioorganic & Medicinal Chemistry Letters. 9: 841-6. PMID 10206547 DOI: 10.1016/S0960-894X(99)00086-4  0.568
1999 Löber S, Hübner H, Gmeiner P. Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps. Bioorganic & Medicinal Chemistry Letters. 9: 97-102. PMID 9990464 DOI: 10.1016/S0960-894X(98)00692-1  0.616
1999 Thomas C, Ohnmacht U, Niger M, Gmeiner P. Beta-analogs of PLG (L-prolyl-L-leucyl-glycinamide): ex-chiral pool syntheses and dopamine D2 receptor modulating effects. Bioorganic & Medicinal Chemistry Letters. 8: 2885-90. PMID 9873642 DOI: 10.1016/S0960-894X(98)00507-1  0.439
1996 Gmeiner P, Kärtner A, Mierau J. Synthesis and dopamine receptor binding studies of homochiral 8-aminopyrido[1,2-a]indoles. Archiv Der Pharmazie. 328: 626-8. PMID 7492270 DOI: 10.1002/ARDP.19953280712  0.569
1996 Gmeiner P, Bollinger B, Mierau J, Höfner G. Synthesis, pharmacological investigation and computational studies on a tricyclic ergoline analog with selective dopamine autoreceptor activity. Archiv Der Pharmazie. 328: 609-14. PMID 7492266 DOI: 10.1002/ARDP.19953280708  0.532
1996 Gmeiner P, Bollinger B, Lotter H. Synthesis and stereochemistry of oxazolo[4′,5′:1,2]benz[5,4,3-c, d]-indole derivatives as intermediates on the way to a selective dopamine autoreceptor agonist Journal of Heterocyclic Chemistry. 33: 481-483. DOI: 10.1002/JHET.5570330243  0.465
1995 Gmeiner P, Sommer J, Höfner G. Synthesis and dopamine receptor binding of 3-phenylazepino[5,4,3-c,d]indole derivatives. Archiv Der Pharmazie. 328: 329-32. PMID 7611828 DOI: 10.1002/ARDP.19953280407  0.557
1993 Gmeiner P, Sommer J, Höfner G, Mierau J. Tricyclic azaergoline analogues: synthesis, structural modifications, and pharmacological studies. Archiv Der Pharmazie. 325: 649-55. PMID 1361322 DOI: 10.1002/ARDP.19923251007  0.486
1993 Gmeiner P, Sommer J, Mierau J, Höfner G. Dopamine autoreceptor agonists: computational studies, synthesis and biological investigations Bioorganic & Medicinal Chemistry Letters. 3: 1477-1483. DOI: 10.1016/S0960-894X(00)80003-7  0.339
1992 Gmeiner P, Mierau J, Höfner G. Enantiomerically pure aminoindolizines: bicyclic ergoline analogues with dopamine autoreceptor activity. Archiv Der Pharmazie. 325: 57-60. PMID 1605713 DOI: 10.1002/ARDP.19923250113  0.32
Low-probability matches (unlikely to be authored by this person)
2015 Gmeiner P. Selective GPCR ligands. Bioorganic & Medicinal Chemistry. 23: 3879. PMID 25818769 DOI: 10.1016/j.bmc.2015.03.030  0.293
2020 Drakopoulos A, Koszegi Z, Lanoiselée Y, Hübner H, Gmeiner P, Calebiro D, Decker M. Investigation of Inactive-State κ Opioid Receptor Homodimerization via Single-Molecule Microscopy Using New Antagonistic Fluorescent Probes. Journal of Medicinal Chemistry. 63: 3596-3609. PMID 32159953 DOI: 10.1021/acs.jmedchem.9b02011  0.29
2020 Ott J, Spilhaug MM, Maschauer S, Rafique W, Jakobsson JE, Hartvig K, Hübner H, Gmeiner P, Prante O, Riss PJ. Pharmacological Characterization of Low-to-Moderate Affinity Opioid Receptor Agonists and Brain Imaging with F-Labeled Derivatives in Rats. Journal of Medicinal Chemistry. 63: 9484-9499. PMID 32787100 DOI: 10.1021/acs.jmedchem.0c00683  0.288
2019 Scheiner M, Dolles D, Gunesch S, Hoffmann M, Nabissi M, Marinelli O, Naldi M, Bartolini M, Petralla S, Poeta E, Monti B, Falkeis C, Vieth M, Hübner H, Gmeiner P, et al. Dual-Acting Cholinesterase-Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo. Journal of Medicinal Chemistry. PMID 31609608 DOI: 10.1021/Acs.Jmedchem.9B00623  0.285
2020 Gentzsch C, Seier K, Drakopoulos A, Jobin ML, Lanoiselée Y, Koszegi Z, Maurel D, Sounier R, Hübner H, Gmeiner P, Granier S, Calebiro D, Decker M. Selective and Wash-Resistant Fluorescent Dihydrocodeinone Derivatives Allow Single-Molecule Imaging of μ-Opioid Receptor Dimerization. Angewandte Chemie (International Ed. in English). 59: 5958-5964. PMID 31808251 DOI: 10.1002/anie.201912683  0.285
2023 Gradl S, Zantop V, Gmeiner P, Hübner H, Heinrich MR. Selectfluor-mediated chlorination and fluorination of arenes: late stage functionalization of APIs and its biological effects. Chemmedchem. e202300144. PMID 37088715 DOI: 10.1002/cmdc.202300144  0.283
2020 She X, Pegoli A, Gruber CG, Wifling D, Carpenter J, Hübner H, Chen M, Wan J, Bernhardt G, Gmeiner P, Holliday ND, Keller M. Red-emitting dibenzodiazepinone derivatives as fluorescent dualsteric probes for the muscarinic acetylcholine M receptor. Journal of Medicinal Chemistry. PMID 32233403 DOI: 10.1021/acs.jmedchem.9b02172  0.28
2020 Huang W, Manglik A, Venkatakrishnan AJ, Laeremans T, Feinberg EN, Sanborn AL, Kato HE, Livingston KE, Thorsen TS, Kling RC, Granier S, Gmeiner P, Husbands SM, Traynor JR, Weis WI, et al. Author Correction: Structural insights into μ-opioid receptor activation. Nature. PMID 32724208 DOI: 10.1038/S41586-020-2542-Z  0.273
2020 Keller M, Mahuroof SA, Hong Yee V, Carpenter J, Schindler L, Littmann T, Pegoli A, Hübner H, Bernhardt G, Gmeiner P, Holliday ND. Fluorescence Labeling of Neurotensin(8-13) via Arginine Residues Gives Molecular Tools with High Receptor Affinity. Acs Medicinal Chemistry Letters. 11: 16-22. PMID 31938457 DOI: 10.1021/acsmedchemlett.9b00462  0.272
2020 Gentzsch C, Seier K, Drakopoulos A, Jobin M, Lanoiselée Y, Koszegi Z, Maurel D, Sounier R, Hübner H, Gmeiner P, Granier S, Calebiro D, Decker M. Inside Back Cover: Selective and Wash‐Resistant Fluorescent Dihydrocodeinone Derivatives Allow Single‐Molecule Imaging of μ‐Opioid Receptor Dimerization (Angew. Chem. Int. Ed. 15/2020) Angewandte Chemie International Edition. 59: 6289-6289. DOI: 10.1002/anie.202002281  0.272
2021 Weinhart CG, Wifling D, Schmidt MF, Neu E, Höring C, Clark T, Gmeiner P, Keller M. Dibenzodiazepinone-type muscarinic receptor antagonists conjugated to basic peptides: Impact of the linker moiety and unnatural amino acids on MR selectivity. European Journal of Medicinal Chemistry. 213: 113159. PMID 33571911 DOI: 10.1016/j.ejmech.2021.113159  0.272
2020 Gentzsch C, Seier K, Drakopoulos A, Jobin M, Lanoiselée Y, Koszegi Z, Maurel D, Sounier R, Hübner H, Gmeiner P, Granier S, Calebiro D, Decker M. Innenrücktitelbild: Selective and Wash‐Resistant Fluorescent Dihydrocodeinone Derivatives Allow Single‐Molecule Imaging of μ‐Opioid Receptor Dimerization (Angew. Chem. 15/2020) Angewandte Chemie. 132: 6348-6348. DOI: 10.1002/ange.202002281  0.271
2022 Gmeiner P, Wang H, Hetzer F, Huang W, Qu Q, Meyerowitz J, Kaindl J, Hübner H, Skiniotis G, Kobilka BK. Structure-based Evolution of G protein-biased μ-opioid Receptor Agonists. Angewandte Chemie (International Ed. in English). PMID 35385593 DOI: 10.1002/anie.202200269  0.264
2017 Simeth NA, Bause M, Dobmeier M, Kling RC, Lachmann D, Hübner H, Einsiedel J, Gmeiner P, König B. NTS2-selective neurotensin mimetics with tetrahydrofuran amino acids. Bioorganic & Medicinal Chemistry. 25: 350-359. PMID 27842797 DOI: 10.1016/J.Bmc.2016.10.039  0.264
2016 Kling RC, Clark T, Gmeiner P. Comparative MD simulations indicate a dual role for Arg1323.50 in dopamine-dependent D2R activation Plos One. 11. DOI: 10.1371/journal.pone.0146612  0.263
2021 Konieczny A, Conrad M, Ertl FJ, Gleixner J, Gattor AO, Grätz L, Schmidt MF, Neu E, Horn AHC, Wifling D, Gmeiner P, Clark T, Sticht H, Keller M. N-Terminus to Arginine Side-Chain Cyclization of Linear Peptidic Neuropeptide Y Y Receptor Ligands Results in Picomolar Binding Constants. Journal of Medicinal Chemistry. 64: 16746-16769. PMID 34748345 DOI: 10.1021/acs.jmedchem.1c01574  0.258
2013 Sparr C, Purkayastha N, Yoshinari T, Seebach D, Maschauer S, Prante O, Hübner H, Gmeiner P, Kolesinska B, Cescato R, Waser B, Reubi JC. Syntheses, receptor bindings, in vitro and in vivo stabilities and biodistributions of DOTA-neurotensin(8-13) derivatives containing β-amino acid residues - a lesson about the importance of animal experiments. Chemistry & Biodiversity. 10: 2101-21. PMID 24327436 DOI: 10.1002/Cbdv.201300331  0.256
2015 Möller D, Gmeiner P. Arrestin-Bound Rhodopsin: A Molecular Structure and its Impact on the Development of Biased GPCR Ligands. Angewandte Chemie (International Ed. in English). 54: 13166-8. PMID 26361376 DOI: 10.1002/anie.201507724  0.256
2024 Sink A, Gerwe H, Hübner H, Boivin-Jahns V, Fender J, Lorenz K, Gmeiner P, Decker M. "Photo-Adrenalines": Photoswitchable β -Adrenergic Receptor Agonists as Molecular Probes for the Study of Spatiotemporal Adrenergic Signaling. Chemistry (Weinheim An Der Bergstrasse, Germany). e202303506. PMID 38212242 DOI: 10.1002/chem.202303506  0.255
2023 Li Y, Vogel C, Kalinichenko LS, Hübner H, Weikert D, Schaefer N, Gmeiner P, Villmann C, Pischetsrieder M, Müller CP. The beer component hordenine inhibits alcohol addiction-associated behaviours in mice. Addiction Biology. 28: e13305. PMID 37500485 DOI: 10.1111/adb.13305  0.253
2019 Pegoli A, Wifling D, Gruber CG, She X, Hübner H, Bernhardt G, Gmeiner P, Keller M. Conjugation of short peptides to dibenzodiazepinone-type muscarinic acetylcholine receptor ligands determines MR selectivity. Journal of Medicinal Chemistry. PMID 31074983 DOI: 10.1021/acs.jmedchem.8b01967  0.252
2023 Papasergi-Scott MM, Pérez-Hernández G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G. Time-resolved cryo-EM of G protein activation by a GPCR. Biorxiv : the Preprint Server For Biology. PMID 36993214 DOI: 10.1101/2023.03.20.533387  0.249
2024 Casiraghi M, Wang H, Brennan P, Habrian C, Hübner H, Schmidt MF, Maul L, Pani B, Bahriz SMFM, Xu B, White E, Sunahara RK, Xiang YK, Lefkowitz RJ, Isacoff EY, ... ... Gmeiner P, et al. Molecular insights into G protein specificity and biased agonism at the β -adrenergic receptor. Biorxiv : the Preprint Server For Biology. PMID 38586060 DOI: 10.1101/2024.03.28.587240  0.248
2006 Dollinger S, Löber S, Klingenstein R, Korth C, Gmeiner P. A chimeric ligand approach leading to potent antiprion active acridine derivatives: design, synthesis, and biological investigations. Journal of Medicinal Chemistry. 49: 6591-5. PMID 17064077 DOI: 10.1021/JM060773J  0.244
2023 Hegron A, Peach CJ, Tonello R, Seemann P, Teng S, Latorre R, Huebner H, Weikert D, Rientjes J, Veldhuis NA, Poole DP, Jensen DD, Thomsen ARB, Schmidt BL, Imlach WL, ... Gmeiner P, et al. Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief. Proceedings of the National Academy of Sciences of the United States of America. 120: e2220979120. PMID 37216510 DOI: 10.1073/pnas.2220979120  0.243
2009 Klieber MA, Scholz O, Lochner S, Gmeiner P, Hillen W, Muller YA. Structural origins for selectivity and specificity in an engineered bacterial repressor-inducer pair. The Febs Journal. 276: 5610-21. PMID 19712110 DOI: 10.1111/j.1742-4658.2009.07254.x  0.242
2024 Papasergi-Scott MM, Pérez-Hernández G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G. Time-resolved cryo-EM of G-protein activation by a GPCR. Nature. PMID 38480881 DOI: 10.1038/s41586-024-07153-1  0.242
2019 Yaksh TL, Eddinger KA, Kokubu S, Wang Z, DiNardo A, Ramachandran R, Zhu Y, He Y, Weren F, Quang D, Malkmus SA, Lansu K, Kroeze WK, Eliceiri B, Steinauer JJ, ... ... Gmeiner P, et al. Mast Cell Degranulation and Fibroblast Activation in the Morphine-induced Spinal Mass: Role of Mas-related G Protein-coupled Receptor Signaling. Anesthesiology. 131: 132-147. PMID 31225809 DOI: 10.1097/ALN.0000000000002730  0.233
2011 Kekewska A, Hübner H, Gmeiner P, Pertz HH. The bulky N6 substituent of cabergoline is responsible for agonism of this drug at 5-hydroxytryptamine 5-HT2A and 5-HT2B receptors and thus is a determinant of valvular heart disease. The Journal of Pharmacology and Experimental Therapeutics. 338: 381-91. PMID 21518772 DOI: 10.1124/jpet.111.181255  0.228
2020 Fischer O, Hofmann J, Rampp H, Kaindl J, Pratsch G, Bartuschat A, Taudte RV, Fromm MF, Hübner H, Gmeiner P, Heinrich MR. Regiospecific introduction of halogens on the 2-aminobiphenyl subunit leads to highly potent and selective M3 muscarinic acetylcholine receptor antagonists and weak inverse agonists. Journal of Medicinal Chemistry. PMID 32202101 DOI: 10.1021/acs.jmedchem.0c00297  0.224
2009 Kormann C, Pimenta I, Löber S, Wimmer C, Lanig H, Clark T, Hillen W, Gmeiner P. Diarylpropane-1,3-dione derivatives as TetR-inducing tetracycline mimetics: Synthesis and biological investigations. Chembiochem. 10: 2924-2933. PMID 19885899 DOI: 10.1002/Cbic.200900564  0.22
2021 Bathe-Peters M, Gmach P, Boltz HH, Einsiedel J, Gotthardt M, Hübner H, Gmeiner P, Lohse MJ, Annibale P. Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34088840 DOI: 10.1073/pnas.2101119118  0.219
2016 Keller M, Kuhn KK, Einsiedel J, Hübner H, Biselli S, Mollereau C, Wifling D, Svobodová J, Bernhardt G, Cabrele C, Vanderheyden PML, Gmeiner P, Buschauer A. Mimicking of Arginine by Functionalized Nω-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples Journal of Medicinal Chemistry. 59: 1925-1945. DOI: 10.1021/acs.jmedchem.5b01495  0.217
2016 Keller M, Kuhn KK, Einsiedel J, Hübner H, Biselli S, Mollereau C, Wifling D, Svobodová J, Bernhardt G, Cabrele C, Vanderheyden PM, Gmeiner P, Buschauer A. Mimicking of Arginine by Functionalized N(ω)-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples. Journal of Medicinal Chemistry. 59: 1925-45. PMID 26824643 DOI: 10.1021/acs.jmedchem.5b01495  0.215
2003 Hoffmann T, Waibel R, Gmeiner P. A general approach to dehydro-Freidinger lactams: ex-chiral pool synthesis and spectroscopic evaluation as potential reverse turn inducers. The Journal of Organic Chemistry. 68: 62-9. PMID 12515462 DOI: 10.1021/jo0261653  0.208
2006 Berens C, Lochner S, Löber S, Usai I, Schmidt A, Drueppel L, Hillen W, Gmeiner P. Subtype selective tetracycline agonists and their application for a two-stage regulatory system. Chembiochem : a European Journal of Chemical Biology. 7: 1320-4. PMID 16871602 DOI: 10.1002/cbic.200600226  0.204
2011 Seebach D, Lukaszuk A, Patora-Komisarska K, Podwysocka D, Gardiner J, Ebert MO, Reubi JC, Cescato R, Waser B, Gmeiner P, Hübner H, Rougeot C. On the terminal homologation of physiologically active peptides as a means of increasing stability in human serum--neurotensin, opiorphin, B27-KK10 epitope, NPY. Chemistry & Biodiversity. 8: 711-39. PMID 21560227 DOI: 10.1002/Cbdv.201100093  0.2
2009 Paul A, Einsiedel J, Waibel R, Heinemann FW, Meyer K, Gmeiner P. ChemInform Abstract: Novel Triazolopeptides: Chirospecific Synthesis and Conformational Studies of Proline Derived Analogues. Cheminform. 40. DOI: 10.1002/chin.200947174  0.194
1995 Gmeiner P, Hummel E, Haubmann C, Höfner G. Synthesis of (S)-3,4-diaminobutanenitriles as precursors for 3-amino-GABA derivatives. Archiv Der Pharmazie. 328: 265-8. PMID 7763142 DOI: 10.1002/ARDP.19953280311  0.19
2013 Paulke A, Kremer C, Wunder C, Achenbach J, Djahanschiri B, Elias A, Schwed JS, Hübner H, Gmeiner P, Proschak E, Toennes SW, Stark H. Argyreia nervosa (Burm. f.): receptor profiling of lysergic acid amide and other potential psychedelic LSD-like compounds by computational and binding assay approaches. Journal of Ethnopharmacology. 148: 492-7. PMID 23665164 DOI: 10.1016/j.jep.2013.04.044  0.186
2015 Maschauer S, Greff C, Einsiedel J, Ott J, Tripal P, Hübner H, Gmeiner P, Prante O. Improved radiosynthesis and preliminary in vivo evaluation of a (18)F-labeled glycopeptide-peptoid hybrid for PET imaging of neurotensin receptor 2. Bioorganic & Medicinal Chemistry. 23: 4026-33. PMID 25691211 DOI: 10.1016/j.bmc.2015.01.053  0.183
2004 Henssler EM, Scholz O, Lochner S, Gmeiner P, Hillen W. Structure-based design of Tet repressor to optimize a new inducer specificity. Biochemistry. 43: 9512-8. PMID 15260494 DOI: 10.1021/BI049682J  0.18
2007 Einsiedel J, Lanig H, Waibel R, Gmeiner P. Molecular building kit of fused-proline-derived peptide mimetics allowing specific adjustment of the dihedral Psi angle. The Journal of Organic Chemistry. 72: 9102-13. PMID 17958374 DOI: 10.1021/jo701703e  0.178
2017 Maschauer S, Einsiedel J, Reich D, Hübner H, Gmeiner P, Wester HJ, Prante O, Notni J. Theranostic Value of Multimers: Lessons Learned from Trimerization of Neurotensin Receptor Ligands and Other Targeting Vectors. Pharmaceuticals (Basel, Switzerland). 10. PMID 28287433 DOI: 10.3390/ph10010029  0.175
2006 Klingenstein R, Löber S, Kujala P, Godsave S, Leliveld SR, Gmeiner P, Peters PJ, Korth C. Tricyclic antidepressants, quinacrine and a novel, synthetic chimera thereof clear prions by destabilizing detergent-resistant membrane compartments. Journal of Neurochemistry. 98: 748-59. PMID 16749906 DOI: 10.1111/j.1471-4159.2006.03889.x  0.171
2023 Liu F, Kaplan AL, Levring J, Einsiedel J, Tiedt S, Distler K, Omattage NS, Kondratov IS, Moroz YS, Pietz HL, Irwin JJ, Gmeiner P, Shoichet BK, Chen J. Structure-based discovery of CFTR potentiators and inhibitors. Biorxiv : the Preprint Server For Biology. PMID 37745391 DOI: 10.1101/2023.09.09.557002  0.164
2010 Lochner S, Einsiedel J, Schaefer G, Berens C, Hillen W, Gmeiner P. Anhydrotetracycline-peptide conjugates as representatives for ligand-based transactivating systems. Bioorganic & Medicinal Chemistry. 18: 6127-33. PMID 20638851 DOI: 10.1016/j.bmc.2010.06.061  0.163
2007 Bittermann H, Böckler F, Einsiedel J, Gmeiner P. A highly practical RCM approach towards a molecular building kit of spirocyclic reverse turn mimics. Chemistry (Weinheim An Der Bergstrasse, Germany). 12: 6315-22. PMID 16729342 DOI: 10.1002/CHEM.200600432  0.163
2023 Xu X, Shonberg J, Kaindl J, Clark MJ, Stößel A, Maul L, Mayer D, Hübner H, Hirata K, Venkatakrishnan AJ, Dror RO, Kobilka BK, Sunahara RK, Liu X, Gmeiner P. Author Correction: Constrained catecholamines gain βAR selectivity through allosteric effects on pocket dynamics. Nature Communications. 14: 2992. PMID 37225685 DOI: 10.1038/s41467-023-38820-y  0.156
2010 Usai I, Krueger M, Einsiedel J, Hillen W, Gmeiner P. Click-chemistry-derived tetracycline-amino acid conjugates exhibiting exceptional potency and exclusive recognition of the reverse tet repressor. Chembiochem : a European Journal of Chemical Biology. 11: 703-12. PMID 20148427 DOI: 10.1002/cbic.200900710  0.156
1989 GMEINER P, SCHUENEMANN J. ChemInform Abstract: Azaindole Derivatives. Part 2. Synthesis and Analgesic Activity of Pyrazolo(1,5-a)pyridines. Cheminform. 20. DOI: 10.1002/CHIN.198908193  0.155
1994 Gmeiner P, Junge D, Kartner A. Enantiomerically pure amino alcohols and diamino alcohols from L-aspartic acid. Application to the synthesis of epi- and diepislaframine Journal of Organic Chemistry. 59: 6766-6776. DOI: 10.1021/jo00101a042  0.15
2004 Bergauer M, Hübner H, Gmeiner P. Practical ex-chiral-pool methodology for the synthesis of dopaminergic tetrahydroindoles Tetrahedron. 60: 1197-1204. DOI: 10.1016/J.TET.2003.11.041  0.146
2016 Maschauer S, Einsiedel J, Hübner H, Gmeiner P, Prante O. (18)F- and (68)Ga-Labeled Neurotensin Peptides for PET Imaging of Neurotensin Receptor 1. Journal of Medicinal Chemistry. 59: 6480-92. PMID 27336295 DOI: 10.1021/acs.jmedchem.6b00675  0.146
1990 Gmeiner P, Sommer J. Synthesis of Tricyclic Azaergoline Analogues Synthese tricyclischer Azaergolin-Analoga Archiv Der Pharmazie. 323: 991-993. DOI: 10.1002/ARDP.19903231210  0.145
2018 Rhein C, Löber S, Gmeiner P, Gulbins E, Tripal P, Kornhuber J. Derivatization of common antidepressant drugs increases inhibition of acid sphingomyelinase and reduces induction of phospholipidosis. Journal of Neural Transmission (Vienna, Austria : 1996). 125: 1837-1845. PMID 30191367 DOI: 10.1007/S00702-018-1923-Z  0.145
1993 Gmeiner P, Kärtner A, Junge D. Practical EPC synthesis of 1,2- and 1,3-amino alcohols Tetrahedron Letters. 34: 4325-4326. DOI: 10.1016/S0040-4039(00)79340-3  0.144
2006 Othersen OG, Waibel R, Lanig H, Gmeiner P, Clark T. SCRF-DFT and NMR comparison of tetracycline and 5a,6-anhydrotetracycline in solution. The Journal of Physical Chemistry. B. 110: 24766-74. PMID 17134242 DOI: 10.1021/Jp064457S  0.143
2001 Ortner B, Hübner H, Gmeiner P. Planar chiral indoles: synthesis and biological effects of the enantiomers Tetrahedron: Asymmetry. 12: 3205-3208. DOI: 10.1016/S0957-4166(01)00558-4  0.141
2009 Paul A, Einsiedel J, Waibel R, Heinemann FW, Meyer K, Gmeiner P. Novel triazolopeptides: chirospecific synthesis and conformational studies of proline derived analogs Tetrahedron. 65: 6156-6168. DOI: 10.1016/J.Tet.2009.05.045  0.14
2010 Thomas C, Ohnmacht U, Zahn K, Mohr K, Gmeiner P. ChemInform Abstract: Ex-Chiral Pool Synthesis and Pharmacological Aspects of 3-Pyrrolidinylisoxazoles. Cheminform. 30: no-no. DOI: 10.1002/CHIN.199931154  0.139
2003 Einsiedel J, Schoerner C, Gmeiner P. Synthesis of dihydrooxazole analogues derived from linezolid Tetrahedron. 59: 3403-3407. DOI: 10.1016/S0040-4020(03)00490-3  0.137
1988 EIDEN F, GMEINER P. ChemInform Abstract: Studies on Pyran Derivatives. Part 123. Oxabenzomorphanes: Synthesis of CNS-Effective Hexahydro-2,7-methano-1,5-benzoxazonines. Cheminform. 19. DOI: 10.1002/CHIN.198844220  0.136
1988 EIDEN F, GMEINER P, LOTTER H. ChemInform Abstract: Pyrans. Part 123. Regio- and Diastereoselective Syntheses of Hexahydro-4a,9-propanoxanthenones. Cheminform. 19. DOI: 10.1002/CHIN.198820164  0.133
2010 Maschauer S, Einsiedel J, Hocke C, Hübner H, Kuwert T, Gmeiner P, Prante O. Synthesis of a (68)ga-labeled peptoid-Peptide hybrid for imaging of neurotensin receptor expression in vivo. Acs Medicinal Chemistry Letters. 1: 224-8. PMID 24900199 DOI: 10.1021/ml1000728  0.131
2014 Haubner R, Maschauer S, Einsiedel J, Eder IE, Rangger C, Gmeiner P, Virgolini IJ, Prante O. H-CRRETAWAC-OH, a lead structure for the development of radiotracer targeting integrin α5β1? Biomed Research International. 2014: 243185. PMID 25374888 DOI: 10.1155/2014/243185  0.129
2010 GMEINER P, SOMMER J. ChemInform Abstract: Synthesis of Tricyclic Azaergoline Analogues (IX). Cheminform. 22: no-no. DOI: 10.1002/CHIN.199114281  0.129
2011 Pinsker A, Einsiedel J, Härterich S, Waibel R, Gmeiner P. A highly efficient type I β-turn mimetic simulating an Asx-Pro-turn-like structure. Organic Letters. 13: 3502-5. PMID 21657240 DOI: 10.1021/ol201313q  0.128
2015 Hutterer C, Niemann I, Milbradt J, Fröhlich T, Reiter C, Kadioglu O, Bahsi H, Zeitträger I, Wagner S, Einsiedel J, Gmeiner P, Vogel N, Wandinger S, Godl K, Stamminger T, et al. The broad-spectrum antiinfective drug artesunate interferes with the canonical nuclear factor kappa B (NF-κB) pathway by targeting RelA/p65. Antiviral Research. PMID 26546752 DOI: 10.1016/J.Antiviral.2015.10.003  0.128
1991 Gmeiner P. Synthesis of Chiral Indolizines as Bicyclic Ergoline Analogues Heterocycles. 32: 1499. DOI: 10.3987/COM-90-5578  0.128
2010 GMEINER P. ChemInform Abstract: Synthesis of Chiral Indolizines as Bicyclic Ergoline Analogues. Cheminform. 23: no-no. DOI: 10.1002/CHIN.199204192  0.128
1990 GMEINER P, LERCHE H. ChemInform Abstract: New and Efficient Synthesis of 5,6,7,8-Tetrahydroindolizidines. Application to the Synthesis of Pharmacologically Relevant Chiral Amino Derivatives from L-Asparagine. Cheminform. 21. DOI: 10.1002/CHIN.199031187  0.128
1988 EIDEN F, GMEINER P. ChemInform Abstract: Synthesis of CNS-Active Pyran, Thiopyran, and Piperidine Anellated Oxacarbabenzomorphanes. Cheminform. 19. DOI: 10.1002/CHIN.198848199  0.123
2001 Weber K, Ohnmacht U, Gmeiner P. ChemInform Abstract: Enantiopure 4- and 5-Aminopiperidin-2-ones: Regiocontrolled Synthesis and Conformational Characterization as Bioactive β-Turn Mimetics. Cheminform. 32: no-no. DOI: 10.1002/CHIN.200112143  0.121
2005 Gmeiner P. European Journal of Pharmaceutics and Biopharmaceutics. 59: 243. DOI: 10.1016/j.ejpb.2004.09.007  0.12
2024 Sure F, Einsiedel J, Gmeiner P, Duchstein P, Zahn D, Korbmacher C, Ilyaskin AV. The small molecule activator S3969 stimulates the epithelial sodium channel by interacting with a specific binding pocket in the channel's β-subunit. The Journal of Biological Chemistry. 300: 105785. PMID 38401845 DOI: 10.1016/j.jbc.2024.105785  0.12
2010 Mangels C, Kellner R, Einsiedel J, Weiglmeier PR, Rosch P, Gmeiner P, Schwarzinger S. The therapeutically anti-prion active antibody-fragment scFv-W226: paramagnetic relaxation-enhanced NMR spectroscopy aided structure elucidation of the paratope-epitope interface. Journal of Biomolecular Structure & Dynamics. 28: 13-22. PMID 20476792 DOI: 10.1080/07391102.2010.10507340  0.118
1994 Gmeiner P, Hummel E. Diastereoselective Synthesis of theC 2-Symmetric 2,3-Diaminotetralin via Electrophilic Amination Synthesis. 1994: 1026-1028. DOI: 10.1055/S-1994-25629  0.117
1990 Gmeiner P, Lerche H. New and Efficient Synthesis of 5,6,7,8-Tetrahydroindolizidines. Application to the Synthesis of Pharmacologically Relevant Chiral Aminoderivatives from L-Asparagine Heterocycles. 31: 9. DOI: 10.3987/COM-89-5202  0.116
2010 Lehmann T, Michel D, Glaenzel M, Waibel R, Gmeiner P. ChemInform Abstract: Chemo- and Regioselective Syntheses of Enantiopure Aminopyrrolidinones as Building Blocks for Constrained Peptidomimetics. Cheminform. 31: no-no. DOI: 10.1002/CHIN.200008134  0.115
2013 Lang C, Maschauer S, Hübner H, Gmeiner P, Prante O. Synthesis and evaluation of a (18)F-labeled diarylpyrazole glycoconjugate for the imaging of NTS1-positive tumors. Journal of Medicinal Chemistry. 56: 9361-5. PMID 24160350 DOI: 10.1021/jm401491e  0.114
2019 Sawengngen N, Chalikidi PN, Araby S, Hampel F, Gmeiner P, Serdyuk OV. Synthesis of pyrazolylvinyl ketones from furan derivatives. Organic & Biomolecular Chemistry. 17: 4850-4855. PMID 31037280 DOI: 10.1039/c9ob00701f  0.114
2007 Prante O, Einsiedel J, Haubner R, Gmeiner P, Wester HJ, Kuwert T, Maschauer S. 3,4,6-Tri-O-acetyl-2-deoxy-2-[18F]fluoroglucopyranosyl phenylthiosulfonate: a thiol-reactive agent for the chemoselective 18F-glycosylation of peptides. Bioconjugate Chemistry. 18: 254-62. PMID 17226980 DOI: 10.1021/BC060340V  0.114
2010 GMEINER P, SOMMER J. ChemInform Abstract: Stereoelectronically Controlled Cyclization Reactions on the Way to peri-Fused Tetrahydropyrazolo(1,5-a)pyridines as Aza Analogues of Ergoline Partial Structures. Cheminform. 22: no-no. DOI: 10.1002/CHIN.199148169  0.113
1999 Gmeiner P, Lehmann T, Michel D, Glänzel M, Waibel R. Chemo- and Regioselective Syntheses of Enantiopure Aminopyrrolidinones as Building Blocks for Constrained Peptidomimetics Heterocycles. 51: 1389. DOI: 10.3987/COM-99-8504  0.111
1991 Gmeiner P, Sommer J. Stereoelectronically controlled cyclization reactions on the way toperi-fused tetrahydropyrazolo[1,5-a]pyridines as aza analogs of ergoline partial structures Liebigs Annalen Der Chemie. 1991: 921-927. DOI: 10.1002/JLAC.1991199101157  0.106
2001 Hoffmann T, Lanig H, Waibel R, Gmeiner P. Rational Molecular Design and EPC Synthesis of a Type VI beta-Turn Inducing Peptide Mimetic This work was supported by the BMBF and the Fonds der Chemischen Industrie. EPC=enantiomerically pure compound. Angewandte Chemie (International Ed. in English). 40: 3361-3364. PMID 11592138 DOI: 10.1002/1521-3773(20010917)40:18<3361::AID-ANIE3361>3.0.CO;2-9  0.105
1987 EIDEN F, GMEINER P. ChemInform Abstract: Investigations of Pyrane Derivatives. Part 118. Oxabenzomorphanes: Synthesis, Reactions, and ZNS Activity of 2,6-Methano-1-benzoxocins. Cheminform. 18. DOI: 10.1002/CHIN.198735256  0.105
2001 Aboul-Fadl T, Loeber S, Gmeiner P. ChemInform Abstract: Effective and Variable Functionalization of Pyrazolo[1,5-a]pyridines Involving Palladium-Catalyzed Coupling Reactions. Cheminform. 32: no-no. DOI: 10.1002/CHIN.200109136  0.104
2008 Lomlim L, Einsiedel J, Heinemann FW, Meyer K, Gmeiner P. Proline derived spirobarbiturates as highly effective beta-turn mimetics incorporating polar and functionalizable constraint elements. The Journal of Organic Chemistry. 73: 3608-11. PMID 18363364 DOI: 10.1021/Jo702573Z  0.104
2014 Maschauer S, Ruckdeschel T, Tripal P, Haubner R, Einsiedel J, Hübner H, Gmeiner P, Kuwert T, Prante O. In vivo monitoring of the antiangiogenic effect of neurotensin receptor-mediated radiotherapy by small-animal positron emission tomography: a pilot study. Pharmaceuticals (Basel, Switzerland). 7: 464-81. PMID 24743103 DOI: 10.3390/ph7040464  0.103
2000 Aboul-Fadl T, Löber S, Gmeiner P. Effective and Variable Functionalization of Pyrazolo[1,5-a]pyridines Involving Palladium-Catalyzed Coupling Reactions Synthesis. 2000: 1727-1732. DOI: 10.1055/S-2000-8215  0.101
1999 Gmeiner P, Michel D, Waibel R. Ex-Chiral Pool Synthesis of Aminooxazepinones as Conformationally Restricted b-Amino Acid Analogs Heterocycles. 51: 365. DOI: 10.3987/COM-98-8403  0.1
2010 WEBER K, GMEINER P. ChemInform Abstract: Homo-Freidinger Lactams: Stereoselective Synthesis of 4-Aminopiperidin-2-one Derivatives from Aspartic Acid. Cheminform. 29: no-no. DOI: 10.1002/CHIN.199847158  0.1
1986 EIDEN F, GMEINER P. ChemInform Abstract: Synthesis of Annulated Oxabenzomorphanes. Chemischer Informationsdienst. 17. DOI: 10.1002/CHIN.198637202  0.097
2010 GMEINER P, HUMMEL E. ChemInform Abstract: Diastereoselective Synthesis of the C2-Symmetric 2,3-Diaminotetralin via Electrophilic Amination. Cheminform. 26: no-no. DOI: 10.1002/CHIN.199509105  0.096
1998 Weber K, Gmeiner P. Homo-Freidinger Lactams: Stereoselective Synthesis of 4-Aminopiperidin-2-one Derivatives from Aspartic Acid Synlett. 1998: 885-887. DOI: 10.1055/S-1998-1786  0.096
2004 Löber S, Gmeiner P. Click chemistry on solid support: synthesis of a new REM resin and application for the preparation of tertiary amines Tetrahedron. 60: 8699-8702. DOI: 10.1016/J.TET.2004.05.099  0.095
2010 GMEINER P, BOLLINGER B. ChemInform Abstract: Efficient Methodology for the Preparation of β-Aminotetralin Derivatives via Electrophilic Amination. Cheminform. 23: no-no. DOI: 10.1002/CHIN.199227158  0.093
2016 Pádua RM, Meitinger N, Hennemann M, Schebitz P, Waibel R, Löber S, Gmeiner P, Clark T, Kreis W. Spontaneous butenolide ring formation of pregnane-21-O-malonyl hemiesters under mild reaction conditions is facilitated by the 14β-hydroxy group present in all natural cardenolides Tetrahedron. 72: 4556-4563. DOI: 10.1016/J.Tet.2016.06.024  0.092
2010 GMEINER P, BOLLINGER B. ChemInform Abstract: Asymmetric Synthesis of β-Aminotetralins by Electrophilic Amination. Cheminform. 26: no-no. DOI: 10.1002/CHIN.199508075  0.091
2000 Lehmann T, Gmeiner P. ChemInform Abstract: Synthesis of Enantiopure 8-Aminomethylindolizines from Glutamine by Stereoelectronically Controlled Cationic Cyclization. Cheminform. 31: no-no. DOI: 10.1002/CHIN.200039137  0.09
1991 Gmeiner P, Bollinger B. Efficient methodology for the preparation of β-aminotetralin derivatives via electrophilic amination Tetrahedron Letters. 32: 5927-5930. DOI: 10.1016/S0040-4039(00)79428-7  0.089
1990 Gmeiner P, Feldman PL, Chu-Moyer MY, Rapoport H. An efficient and practical total synthesis of (+)-vincamine from L-aspartic acid Journal of Organic Chemistry. 55: 3068-3074. DOI: 10.1021/Jo00297A023  0.089
2020 Müller C, Weiss E, Hellmann J, Dahlmanns J, Kalinichenko L, Alzheimer C, Löber S, Hübner H, Kornhuber J, Gmeiner P, Grömer T, Uzuneser T. T215. The Antipsychotic Action Of Haloperidol In Psychotic-Like Rats Requires Presynaptic Vesicular Accumulation Schizophrenia Bulletin. 46. DOI: 10.1093/Schbul/Sbaa029.775  0.088
2009 Singh MP, Hörste GMz, Hu W, Mausberg AK, Cravens PD, Eagar T, Löber S, Klingenstein R, Gmeiner P, Korth C, Kieseier BC, Stüve O. Quinpramine is a novel compound effective in ameliorating brain autoimmune disease Experimental Neurology. 215: 397-400. PMID 18996373 DOI: 10.1016/J.Expneurol.2008.10.001  0.087
1994 Gmeiner P, Bollinger B. Asymmetric synthesis of β-aminotetralins by electrophilic amination Tetrahedron. 50: 10909-10922. DOI: 10.1016/S0040-4020(01)85702-1  0.087
2010 Hoffmann T, Gmeiner P. ChemInform Abstract: Short and Efficient Synthesis of Homo-Freidinger Lactams: An Olefin Metathesis Approach Towards Conformationally Restricted β-Amino Acid Analogues. Cheminform. 33: no-no. DOI: 10.1002/CHIN.200242214  0.086
2006 Bittermann H, Gmeiner P. Chirospecific synthesis of spirocyclic beta-lactams and their characterization as potent type II beta-turn inducing peptide mimetics. The Journal of Organic Chemistry. 71: 97-102. PMID 16388623 DOI: 10.1021/JO0517287  0.085
2000 Gmeiner P, Lehmann T. Synthesis of Enantiopure 8-Aminomethylindolizines from Glutamine by Stereoelectronically Controlled Cationic Cyclization Heterocycles. 53: 1371. DOI: 10.3987/COM-00-8883  0.085
2010 GMEINER P, KRAXNER J, BOLLINGER B. ChemInform Abstract: Diethoxymethyl Protected Indoles: Synthesis and Regioselective Transformations. Cheminform. 28: no-no. DOI: 10.1002/CHIN.199711097  0.084
2002 Hoffmann T, Gmeiner P. Short and Efficient Synthesis of Homo-Freidinger Lactams: An Olefin Metathesis Approach Towards Conformationally Restricted β-Amino Acid Analogues Synlett. 2002: 1014-1016. DOI: 10.1055/S-2002-31916  0.083
2010 GMEINER P. ChemInform Abstract: Selective Transformations of N,N-Dibenzyl Protected Asparagine and Aspartic Acid Derivatives Cheminform. 28: no-no. DOI: 10.1002/chin.199746326  0.081
2010 GMEINER P, KAERTNER A. ChemInform Abstract: 2-Dibenzylaminobutane-1,4-diol: An Effective Chiral Building Block for the Synthesis of 1,2-Amino Alcohols. Cheminform. 26: no-no. DOI: 10.1002/CHIN.199534108  0.08
2011 Andree U, Mueller-Seitz E, Usai I, Loeber S, Gmeiner P, Wimmer C, Hillen W, Petz M. Tetracycline sensing using novel doxycycline derivatives immobilized on different surface plasmon resonance biosensor surfaces. Bioanalysis. 2: 217-27. PMID 21083305 DOI: 10.4155/bio.09.176  0.08
2010 GMEINER P, BOLLINGER B. ChemInform Abstract: Synthesis of Amines and Amino Alcohols by Electrophilic Amination and Highly Stereoselective Reduction. Cheminform. 23: no-no. DOI: 10.1002/CHIN.199227157  0.078
2019 Rebets Y, Nadmid S, Paulus C, Dalem C, Hermann J, Hübner H, Rückert C, Kiemer A, Gmeiner P, Kalinowski J, Müller R, Luzhetskyy A. Perquinolines A-C: Unprecedented Bacterial Tetrahydroisoquinolines Involving an Intriguing Biosynthesis. Angewandte Chemie (International Ed. in English). PMID 31310031 DOI: 10.1002/Anie.201905538  0.077
1989 GMEINER P, SOMMER J. ChemInform Abstract: Azaindole Derivatives. Part 1. Asymmetric Synthesis of a New α-Amino Acid. Cheminform. 20. DOI: 10.1002/CHIN.198908302  0.077
1995 Gmeiner P, Kärtner A. 2-Dibenzylaminobutane-1,4-diol: An Effective Chiral Building Block for the Synthesis of 1,2-Amino Alcohols Synthesis. 1995: 83-86. DOI: 10.1055/S-1995-3846  0.076
2006 Paul A, Bittermann H, Gmeiner P. Triazolopeptides: chirospecific synthesis and cis/trans prolyl ratios of structural isomers Tetrahedron. 62: 8919-8927. DOI: 10.1016/J.TET.2006.07.007  0.075
2006 Paul A, Bittermann H, Gmeiner P. Triazolopeptides: Chirospecific Synthesis and cis/trans Prolyl Ratios of Structural Isomers. Cheminform. 37. DOI: 10.1002/CHIN.200650203  0.075
1992 Gmeiner P, Bollinger B. Synthesis of Amines and Amino Alcohols by Electrophilic Amination and Highly Stereoselective Reduction Liebigs Annalen Der Chemie. 1992: 273-278. DOI: 10.1002/JLAC.199219920147  0.074
2001 Bergauer M, Gmeiner P. Diethoxymethyl Protected Pyrroles: Synthesis and Regioselective Transformations Synthesis. 2001: 2281-2288. DOI: 10.1055/S-2001-18445  0.073
2010 GMEINER P. ChemInform Abstract: General Synthesis of Enantiomerically Pure β-Amino Acids. Cheminform. 22: no-no. DOI: 10.1002/CHIN.199137254  0.072
2010 GMEINER P. ChemInform Abstract: Efficient EPC Synthesis of β-Aminobutanoic Acid. Cheminform. 22: no-no. DOI: 10.1002/CHIN.199132231  0.069
2010 GMEINER P, ORECHER F, THOMAS C, WEBER K. ChemInform Abstract: 2-Dibenzylaminobutane-1,4-diol: A Versatile Intermediate for a Chirospecific β-Amino Acid Synthesis. Cheminform. 26: no-no. DOI: 10.1002/CHIN.199521235  0.069
1990 Gmeiner P. General synthesis of enantiomerically pure β-amino acids Tetrahedron Letters. 31: 5717-5720. DOI: 10.1016/S0040-4039(00)97940-1  0.068
2010 THOMAS C, ORECHER F, GMEINER P. ChemInform Abstract: A Practical Ex-Chiral-Pool Synthesis of β-Proline (XI) and Homo-β-Proline (XVI). Cheminform. 30: no-no. DOI: 10.1002/CHIN.199903189  0.067
1990 GMEINER P, FELDMAN PL, CHU-MOYER MY, RAPOPORT H. ChemInform Abstract: An Efficient and Practical Total Synthesis of (+)-Vincamine (I) from L-Aspartic Acid. Cheminform. 21. DOI: 10.1002/CHIN.199038329  0.066
1988 Eiden F, Gmeiner P. Oxabenzomorphane: Synthese ZNS-wirksamer Hexahydro-2,7-methano-1,5-benzoxazonine Archiv Der Pharmazie. 321: 321-324. DOI: 10.1002/ARDP.19883210604  0.065
1995 Gmeiner P, Orecher F, Thomas C, Weber K. 2-Dibenzylaminobutane-1,4-diol: A versatile intermediate for a chirospecific β-amino acid synthesis Tetrahedron Letters. 36: 381-382. DOI: 10.1016/0040-4039(94)02307-W  0.064
1991 Gmeiner P. Efficient EPC synthesis of β-aminobutanoic acid Liebigs Annalen Der Chemie. 1991: 501-502. DOI: 10.1002/JLAC.199119910190  0.064
2010 GMEINER P. ChemInform Abstract: An Efficient and Practical EPC Synthesis of β-Amino Acids from L-Asparagine. Cheminform. 23: no-no. DOI: 10.1002/CHIN.199217263  0.064
1998 Thomas C, Orecher F, Gmeiner P. A Practical Ex-Chiral-Pool Synthesis of β-Proline and Homo-β-Proline Synthesis. 1998: 1491-1496. DOI: 10.1055/S-1998-2185  0.063
2011 Meyer zu Hörste G, Mausberg AK, Müller JI, Lehmann HC, Löber S, Gmeiner P, Hartung HP, Stüve O, Korth C, Kieseier BC. Quinpramine ameliorates rat experimental autoimmune neuritis and redistributes MHC class II molecules. Plos One. 6: e21223. PMID 21698177 DOI: 10.1371/journal.pone.0021223  0.063
2006 Kormann C, Heinemann FW, Gmeiner P. A consecutive Diels–Alder approach toward a Tet repressor directed combinatorial library Tetrahedron. 62: 6899-6908. DOI: 10.1016/J.TET.2006.04.092  0.06
2010 Gmeiner P. An efficient and practical EPC synthesis of β-amino acids from L-asparagine Archiv Der Pharmazie. 324: 551-557. DOI: 10.1002/ARDP.2503240906  0.06
2000 Weber K, Kuklinski S, Gmeiner P. Treatment of N,N-dibenzylamino alcohols with sulfonyl chloride leads to rearranged beta-chloro amines, precursors to beta-amino acids, and not to tetrahydroisoquinolines. Organic Letters. 2: 647-9. PMID 10814400 DOI: 10.1021/OL991402I  0.058
2007 Pádua RM, Waibel R, Kuate SP, Schebitz PK, Hahn S, Gmeiner P, Kreis W. A simple chemical method for synthesizing malonyl hemiesters of 21-hydroxypregnanes, potential intermediates in cardenolide biosynthesis. Steroids. 73: 458-65. PMID 18249427 DOI: 10.1016/j.steroids.2007.12.012  0.058
2010 Maschauer S, Einsiedel J, Haubner R, Hocke C, Ocker M, Hübner H, Kuwert T, Gmeiner P, Prante O. Labeling and glycosylation of peptides using click chemistry: a general approach to (18)F-glycopeptides as effective imaging probes for positron emission tomography. Angewandte Chemie (International Ed. in English). 49: 976-9. PMID 20029856 DOI: 10.1002/anie.200904137  0.055
2006 Klingenstein R, Lober S, Kujala P, Godsave S, Leliveld SR, Gmeiner P, Peters PJ, Korth C. Tricyclic antidepressants, quinacrine and a novel, synthetic chimera thereof clear prions by destabilizing detergent-resistant membrane compartments Journal of Neurochemistry. 98: 1696-1696. DOI: 10.1111/j.1471-4159.2006.04047.x  0.054
2012 de Pádua RM, Meitinger N, de Souza Filho JD, Waibel R, Gmeiner P, Braga FC, Kreis W. Biotransformation of 21-O-acetyl-deoxycorticosterone by cell suspension cultures of Digitalis lanata (strain W.1.4). Steroids. 77: 1373-80. PMID 22917633 DOI: 10.1016/j.steroids.2012.07.016  0.054
2010 GMEINER P, HUMMEL E, HAUBMANN C. ChemInform Abstract: Synthesis of Optically Active α,β-Disubstituted β- Amino Nitriles and β-Amino Acids Starting from Asparagine. Cheminform. 27: no-no. DOI: 10.1002/CHIN.199607240  0.052
2006 Krueger C, Danke C, Pfleiderer K, Schuh W, Jäck HM, Lochner S, Gmeiner P, Hillen W, Berens C. A gene regulation system with four distinct expression levels. The Journal of Gene Medicine. 8: 1037-47. PMID 16779863 DOI: 10.1002/Jgm.932  0.05
1995 Gmeiner P, Hummel E, Haubmann C. Synthesis of optically active α,β-disubstituted β-amino nitriles and β-amino acids starting from asparagine Liebigs Annalen. 1995: 1987-1992. DOI: 10.1002/JLAC.1995199511278  0.05
2012 Wakchaure S, Einsiedel J, Waibel R, Gmeiner P. ChemInform Abstract: Conformationally Restricted Peptide Mimetics by Ring-Closing Olefin Metathesis. Cheminform. 43: no-no. DOI: 10.1002/CHIN.201251156  0.048
2000 Kraxner J, Gmeiner P. ChemInform Abstract: Regiocontrolled Anellation Reactions Starting from Diethoxymethyl Protected Indole. Cheminform. 31: no-no. DOI: 10.1002/CHIN.200044134  0.047
2010 Weber K, Kuklinski S, Gmeiner P. ChemInform Abstract: Treatment of N,N-Dibenzylamino Alcohols with Sulfonyl Chloride Leads to Rearranged β-Chloro Amines, Precursors to β-Amino Acids, and Not to Tetrahydroisoquinolines. Cheminform. 31: no-no. DOI: 10.1002/CHIN.200024056  0.046
2013 Welzel O, Loy K, Tischbirek CH, Tabor A, Gmeiner P, Kornhuber J, Groemer TW. The pH probe CypHer™5E is effectively quenched by FM dyes. Journal of Fluorescence. 23: 487-94. PMID 23397486 DOI: 10.1007/S10895-013-1164-3  0.046
2007 Pádua R, Waibel R, Kuate S, Riedl P, Gmeiner P, Kreis W. Butenolide ring formation in cardenolide biosynthesis: Spontaneous cyclization of pregnane-21-O-malonyl hemiesters Planta Medica. 73. DOI: 10.1055/S-2007-987133  0.045
2012 Gmeiner P, Wakchaure S, Einsiedel J, Waibel R. Conformationally Restricted Peptide Mimetics by Ring-Closing Olefin Metathesis Synthesis. 44: 2682-2694. DOI: 10.1055/S-0032-1316758  0.042
2007 Leeb L, Gmeiner P, Löber S. Optimization of Click Chemistry Using Azide and Alkyne Scavenger Resins Qsar & Combinatorial Science. 26: 1145-1150. DOI: 10.1002/QSAR.200740065  0.042
2010 GMEINER P, JUNGE D, KAERTNER A. ChemInform Abstract: Enantiomerically Pure Amino Alcohols and Diamino Alcohols from L- Aspartic Acid. Application to the Synthesis of Epi- and Diepislaframine. Cheminform. 26: no-no. DOI: 10.1002/CHIN.199520200  0.042
2010 GMEINER P, JUNGE D. ChemInform Abstract: Regioselective Transformation of Malic Acid: A Practical Method for the Construction of Enantiomerically Pure Indolizidines. Cheminform. 26: no-no. DOI: 10.1002/CHIN.199546172  0.041
2000 Kraxner J, Gmeiner P. Regiocontrolled Annellation Reactions Starting from Diethoxymethyl Protected Indole Synthesis. 2000: 1081-1083. DOI: 10.1055/S-2000-6329  0.039
2010 GMEINER P, KAERTNER A, JUNGE D. ChemInform Abstract: Practical EPC Synthesis of 1,2- and 1,3-Amino Alcohols. Cheminform. 24: no-no. DOI: 10.1002/CHIN.199346122  0.039
2010 Huber R, Krueger B, Diakov A, Korbmacher J, Haerteis S, Einsiedel J, Gmeiner P, Azad AK, Cuppens H, Cassiman J, Korbmacher C, Rauh R. Functional characterization of a partial loss-of-function mutation of the epithelial sodium channel (ENaC) associated with atypical cystic fibrosis. Cellular Physiology and Biochemistry. 25: 145-158. PMID 20054153 DOI: 10.1159/000272059  0.037
2004 Gmeiner P, Bergauer M. Traceless Linking of Pyrroles: General Methology and Solid Phase Supported Functionalizations Synthesis. 2002. DOI: 10.1055/S-2002-19813  0.036
1995 Gmeiner P, Junge D. Regioselective transformation of malic acid: A practical method for the construction of enantiomerically pure indolizidines Journal of Organic Chemistry. 60: 3910-3915. DOI: 10.1021/jo00117a052  0.034
2010 GMEINER P, BOLLINGER B. ChemInform Abstract: Diethoxymethyl: A Useful Nitrogen-Protecting Group for Lactams and Amides. Cheminform. 26: no-no. DOI: 10.1002/CHIN.199532104  0.032
2009 Matecko I, Burmann BM, Schweimer K, Kalbacher H, Einsiedel J, Gmeiner P, Rosch P. Structural Characterisation of the E. coli Heat Stable Enterotoxin STh The Open Spectroscopy Journal. 2: 34-39. DOI: 10.2174/1874383800802010034  0.029
1995 Gmeiner P, Bollinger B. Diethoxymethyl: A Useful Nitrogen-Protecting Group for Lactams and Amides Synthesis. 1995: 168-170. DOI: 10.1055/S-1995-3868  0.023
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