| Year |
Citation |
Score |
| 2022 |
Negrón O, Hur WS, Prasad J, Paul DS, Rowe SE, Degen JL, Abrahams SR, Antoniak S, Conlon BP, Bergmeier W, Hӧӧk M, Flick MJ. Fibrin(ogen) engagement of S. aureus promotes the host antimicrobial response and suppression of microbe dissemination following peritoneal infection. Plos Pathogens. 18: e1010227. PMID 35041705 DOI: 10.1371/journal.ppat.1010227 |
0.593 |
|
| 2021 |
Prasad JM, Negrón O, Du X, Mullins ES, Palumbo JS, Gilbertie JM, Höök M, Grover SP, Pawlinski R, Mackman N, Degen JL, Flick MJ. Host fibrinogen drives antimicrobial function in peritonitis through bacterial-mediated prothrombin activation. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33443167 DOI: 10.1073/pnas.2009837118 |
0.647 |
|
| 2019 |
Gould TW, Dominguez B, de Winter F, Yeo GW, Liu P, Sundararaman B, Stark T, Vu A, Degen JL, Lin W, Lee KF. Glial cells maintain synapses by inhibiting an activity-dependent retrograde protease signal. Plos Genetics. 15: e1007948. PMID 30870413 DOI: 10.1371/Journal.Pgen.1007948 |
0.386 |
|
| 2017 |
Shaw MA, Gao Z, McElhinney KE, Thornton S, Flick MJ, Lane A, Degen JL, Kyu Ryu J, Akassoglou K, Mullins ES. Plasminogen deficiency delays the onset and protects from demyelination and paralysis in autoimmune neuroinflammatory disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28275164 DOI: 10.1523/Jneurosci.2932-15.2017 |
0.661 |
|
| 2016 |
Mignemi NA, Yuasa M, Baker CE, Moore SN, Ihejirika RC, Oelsner WK, Wallace CS, Yoshii T, Okawa A, Revenko AS, MacLeod AF, Bhattacharjee G, Barnett JV, Schwartz HS, Degen JL, et al. Plasmin Prevents Dystrophic Calcification after Muscle Injury. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 27530373 DOI: 10.1002/Jbmr.2973 |
0.56 |
|
| 2016 |
Shaw MA, Kombrinck KW, McElhinney KE, Sweet DR, Flick MJ, Palumbo JS, Cheng M, Esmon NL, Esmon CT, Brill A, Wagner DD, Degen JL, Mullins ES. Limiting prothrombin activation to meizothrombin is compatible with survival but significantly alters hemostasis in mice. Blood. PMID 27252233 DOI: 10.1182/Blood-2015-11-680280 |
0.698 |
|
| 2015 |
Ryu JK, Petersen MA, Murray SG, Baeten KM, Meyer-Franke A, Chan JP, Vagena E, Bedard C, Machado MR, Coronado PE, Prod'homme T, Charo IF, Lassmann H, Degen JL, Zamvil SS, et al. Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation. Nature Communications. 6: 8164. PMID 26353940 DOI: 10.1038/Ncomms9164 |
0.328 |
|
| 2015 |
Yuasa M, Mignemi NA, Nyman JS, Duvall CL, Schwartz HS, Okawa A, Yoshii T, Bhattacharjee G, Zhao C, Bible JE, Obremskey WT, Flick MJ, Degen JL, Barnett JV, Cates JM, et al. Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification. The Journal of Clinical Investigation. 125: 3723. PMID 26325037 DOI: 10.1172/JCI84059 |
0.47 |
|
| 2015 |
Arumugam PI, Mullins ES, Shanmukhappa SK, Monia BP, Loberg A, Shaw MA, Rizvi T, Wansapura J, Degen JL, Malik P. Genetic diminution of circulating prothrombin ameliorates multiorgan pathologies in sickle cell disease mice. Blood. 126: 1844-55. PMID 26286849 DOI: 10.1182/Blood-2015-01-625707 |
0.487 |
|
| 2015 |
Prasad JM, Gorkun OV, Raghu H, Thornton S, Mullins ES, Palumbo JS, Ko YP, Höök M, David T, Coughlin SR, Degen JL, Flick MJ. Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense. Blood. PMID 26228483 DOI: 10.1182/Blood-2015-04-639849 |
0.706 |
|
| 2015 |
Yuasa M, Mignemi NA, Nyman JS, Duvall CL, Schwartz HS, Okawa A, Yoshii T, Bhattacharjee G, Zhao C, Bible JE, Obremskey WT, Flick MJ, Degen JL, Barnett JV, Cates JM, et al. Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification. The Journal of Clinical Investigation. PMID 26214526 DOI: 10.1172/Jci80313 |
0.574 |
|
| 2015 |
Raghu H, Cruz C, Rewerts CL, Frederick MD, Thornton S, Mullins ES, Schoenecker JG, Degen JL, Flick MJ. Transglutaminase factor XIII promotes arthritis through mechanisms linked to inflammation and bone erosion. Blood. 125: 427-37. PMID 25336631 DOI: 10.1182/Blood-2014-08-594754 |
0.672 |
|
| 2014 |
Aleman MM, Byrnes JR, Wang JG, Tran R, Lam WA, Paola JD, Mackman N, Degen JL, Flick MJ, Wolberg AS. Factor XIII activity mediates red blood cell retention in venous thrombi Journal of Clinical Investigation. 124: 3590-3600. PMID 24983320 DOI: 10.1172/Jci75386 |
0.696 |
|
| 2014 |
Davalos D, Baeten KM, Whitney MA, Mullins ES, Friedman B, Olson ES, Ryu JK, Smirnoff DS, Petersen MA, Bedard C, Degen JL, Tsien RY, Akassoglou K. Early detection of thrombin activity in neuroinflammatory disease. Annals of Neurology. 75: 303-8. PMID 24740641 DOI: 10.1002/Ana.24078 |
0.351 |
|
| 2014 |
Cole HA, Ohba T, Nyman JS, Hirotaka H, Cates JMM, Flick MJ, Degen JL, Schoenecker JG. Fibrin accumulation secondary to loss of plasmin-mediated fibrinolysis drives inflammatory osteoporosis in mice Arthritis and Rheumatology. 66: 2222-2233. PMID 24664548 DOI: 10.1002/Art.38639 |
0.646 |
|
| 2014 |
Raghu H, Jone A, Cruz C, Rewerts CL, Frederick MD, Thornton S, Degen JL, Flick MJ. Plasminogen is a joint-specific positive or negative determinant of arthritis pathogenesis in mice. Arthritis & Rheumatology (Hoboken, N.J.). 66: 1504-16. PMID 24574269 DOI: 10.1002/Art.38402 |
0.64 |
|
| 2014 |
Thornton S, Raghu H, Jone A, Cruz C, Rewerts CL, Frederick MD, Degen JL, Flick MJ. Mice Deficient in Urokinase-Type Plasminogen Activator (uPA) or uPA Receptor Develop Significantly Diminished Collagen-Induced Arthritis Blood. 124: 580-580. DOI: 10.1182/Blood.V124.21.580.580 |
0.686 |
|
| 2013 |
Sörensen-Zender I, Rong S, Susnik N, Lange J, Gueler F, Degen JL, Melk A, Haller H, Schmitt R. Role of fibrinogen in acute ischemic kidney injury. American Journal of Physiology. Renal Physiology. 305: F777-85. PMID 23804451 DOI: 10.1152/Ajprenal.00418.2012 |
0.369 |
|
| 2013 |
Borissoff JI, Otten JJT, Heeneman S, Leenders P, van Oerle R, Soehnlein O, Loubele STBG, Hamulyák K, Hackeng TM, Daemen MJAP, Degen JL, Weiler H, Esmon CT, van Ryn J, Biessen EAL, et al. Genetic and Pharmacological Modifications of Thrombin Formation in Apolipoprotein E-deficient Mice Determine Atherosclerosis Severity and Atherothrombosis Onset in a Neutrophil-Dependent Manner Plos One. 8. PMID 23409043 DOI: 10.1371/Journal.Pone.0055784 |
0.498 |
|
| 2013 |
Flick MJ, Du X, Prasad JM, Raghu H, Palumbo JS, Smeds E, Ḧöok M, Degen JL. Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia Blood. 121: 1783-1794. PMID 23299312 DOI: 10.1182/Blood-2012-09-453894 |
0.653 |
|
| 2013 |
Arumugam P, Mullins ES, Shaw MA, Shanmukhappa K, Loberg A, Rizvi T, Wansapura J, Witte D, Malik P, Degen JL. Diminished Multi-Organ Pathologies and Inflammation Associated With Sickle Cell Disease In Mice With Genetically Limited Prothrombin Levels Blood. 122: 729-729. DOI: 10.1182/Blood.V122.21.729.729 |
0.476 |
|
| 2013 |
Aleman MM, Byrnes JR, Wang J, Mackman N, Degen JL, Flick MJ, Wolberg AS. Fibrin Crosslinking Is Required For Retention Of Red Blood Cells In Venous Thrombi, Blood. 122: 451-451. DOI: 10.1182/Blood.V122.21.451.451 |
0.613 |
|
| 2013 |
Mullins ES, Shaw MA, McElhinney KE, Kombrinck KW, Degen JL. Plasmin(ogen) Deficiency Is Protective Against The Development Of Neuroinflammatory Pathologies and Paralysis In a Murine Model Of Multiple Sclerosis Blood. 122: 1090-1090. DOI: 10.1182/Blood.V122.21.1090.1090 |
0.456 |
|
| 2013 |
Ryu JK, Baeten KM, Petersen MA, Murray SG, Meyer-Franke A, Davalos D, Bedard C, Prod’homme T, Charo IF, Lassmann H, Degen JL, Zamvil SS, Akassoglou K. 220 Cytokine. 63: 295. DOI: 10.1016/J.Cyto.2013.06.223 |
0.377 |
|
| 2012 |
Degen JL, Palumbo JS. Hemostatic factors, innate immunity and malignancy Thrombosis Research. 129: S1-S5. PMID 22682116 DOI: 10.1016/S0049-3848(12)70143-3 |
0.351 |
|
| 2012 |
Vidal B, Ardite E, Suelves M, Ruiz-Bonilla V, Janué A, Flick MJ, Degen JL, Serrano AL, Muñoz-Cánoves P. Amelioration of Duchenne muscular dystrophy in mdx mice by elimination of matrix-associated fibrin-driven inflammation coupled to the α mβ 2 leukocyte integrin receptor Human Molecular Genetics. 21: 1989-2004. PMID 22381526 DOI: 10.1093/Hmg/Dds012 |
0.654 |
|
| 2012 |
Meyer A, Wang W, Qu J, Croft L, Degen JL, Coller BS, Ahamed J. Platelet TGF-β1 contributions to plasma TGF-β1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload Blood. 119: 1064-1074. PMID 22134166 DOI: 10.1182/Blood-2011-09-377648 |
0.379 |
|
| 2012 |
Mullins ES, Shaw MA, McElhinney KE, Kombrinck KW, Flick MJ, Brill A, Wagner DD, Degen JL. Mice with Genetic Modifications in Prothrombin Limiting Activation Cleavage Events to Meizothrombin Survive to Adulthood, but Exhibit Alterations in Hemostasis and Thrombus Formation Blood. 120: 496-496. DOI: 10.1182/Blood.V120.21.496.496 |
0.719 |
|
| 2012 |
Spronk HM, Borissoff JI, Soehnlein O, Koenen R, van Oerle R, Heeneman S, Daemen MJ, Esmon CT, Degen JL, Weiler H, van Ryn J, Cate HT. Thrombin Inhibition Prevents Against Severe Atherosclerosis Progression in Prothrombotic Mice Blood. 120: 103-103. DOI: 10.1182/Blood.V120.21.103.103 |
0.507 |
|
| 2011 |
Horowitz NA, Blevins EA, Miller WM, Perry AR, Talmage KE, Mullins ES, Flick MJ, Queiroz KC, Shi K, Spek CA, Conway EM, Monia BP, Weiler H, Degen JL, Palumbo JS. Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain. Blood. 118: 2889-95. PMID 21788337 DOI: 10.1182/Blood-2011-03-341222 |
0.652 |
|
| 2011 |
Sörensen I, Susnik N, Inhester T, Degen JL, Melk A, Haller H, Schmitt R. Fibrinogen, acting as a mitogen for tubulointerstitial fibroblasts, promotes renal fibrosis. Kidney International. 80: 1035-44. PMID 21734641 DOI: 10.1038/Ki.2011.214 |
0.329 |
|
| 2011 |
Flick MJ, Chauhan AK, Frederick M, Talmage KE, Kombrinck KW, Miller W, Mullins ES, Palumbo JS, Zheng X, Esmon NL, Esmon CT, Thornton S, Becker A, Pelc LA, Di Cera E, ... ... Degen JL, et al. The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A. Blood. 117: 6326-37. PMID 21436072 DOI: 10.1182/Blood-2010-08-304915 |
0.706 |
|
| 2011 |
Degen JL, Palumbo JS. Thrombin Control Mechanisms and Thrombin Targets in Cancer Biology Blood. 118: SCI-17-SCI-17. DOI: 10.1182/Blood.V118.21.Sci-17.Sci-17 |
0.433 |
|
| 2011 |
Mullins ES, Talmage KE, Kombrinck KW, Miller WM, Palumbo JS, Degen JL. Factor XIII Deficiency Improves Motor Function in Mice Challenged with Experimental Autoimmune Encephalomyelitis, An Established Model of Multiple Sclerosis Blood. 118: 858-858. DOI: 10.1182/Blood.V118.21.858.858 |
0.481 |
|
| 2011 |
Mignemi N, Cole H, Yausa M, Gailani D, Degen JL, Schoenecker JG. Deficiency in Plasminogen Cause Decreased Vascularity in Sold Tissue Organs and Bone Blood. 118: 857-857. DOI: 10.1182/Blood.V118.21.857.857 |
0.435 |
|
| 2011 |
Meyer A, Wang W, Degen JL, Coller BS, Ahamed J. Mice with Megakaryocyte-Specific Deletion of TGF-β1 Are Partially Protected From Developing Cardiac Fibrosis and Systolic Dysfunction in a Pressure Overload Model Blood. 118: 362-362. DOI: 10.1182/Blood.V118.21.362.362 |
0.391 |
|
| 2011 |
Turpin BK, Miller WM, Mullins ES, Degen JL, Flick MJ, Monia BP, MacLeod R, Revenko AS, Palumbo JS. Thrombin Supports Colitis and Colitis-Associated Cancer Pathogenesis Blood. 118: 2237-2237. DOI: 10.1182/Blood.V118.21.2237.2237 |
0.669 |
|
| 2010 |
Munks MW, McKee AS, MacLeod MK, Powell RL, Degen JL, Reisdorph NA, Kappler JW, Marrack P. Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo Blood. 116: 5191-5199. PMID 20876456 DOI: 10.1182/Blood-2010-03-275529 |
0.34 |
|
| 2010 |
Palumbo JS, Degen JL. Mechanisms coupling the hemostatic system to colitis-associated cancer. Thrombosis Research. 125: S39-43. PMID 20434003 DOI: 10.1016/S0049-3848(10)70011-6 |
0.304 |
|
| 2010 |
Schachtrup C, Ryu JK, Helmrick MJ, Vagena E, Galanakis DK, Degen JL, Margolis RU, Akassoglou K. Fibrinogen triggers astrocyte scar formation by promoting the availability of active TGF-β after vascular damage Journal of Neuroscience. 30: 5843-5854. PMID 20427645 DOI: 10.1523/Jneurosci.0137-10.2010 |
0.327 |
|
| 2010 |
Baeten KM, Richard MC, Kanse SM, Mutch NJ, Degen JL, Booth NA. Activation of single-chain urokinase-type plasminogen activator by platelet-associated plasminogen: A mechanism for stimulation of fibrinolysis by platelets Journal of Thrombosis and Haemostasis. 8: 1313-1322. PMID 20180903 DOI: 10.1111/J.1538-7836.2010.03813.X |
0.339 |
|
| 2010 |
Horowitz NA, Blevins EA, Miller WM, Perry AR, Talmage KE, Mullins ES, Monia BP, Degen JL, Palumbo JS. Thrombin-Thrombomodulin Interactions Are An Important Determinant of Metastatic Potential Blood. 116: 822-822. DOI: 10.1182/Blood.V116.21.822.822 |
0.5 |
|
| 2010 |
Flick MJ, Du X, Fausnacht L, Raghu H, Talmage KE, Kombrinck KW, Blevins EA, Mullins ES, Palumbo JS, Degen JL. Host Prothrombin and Fibrinogen Support S. Aureus Virulence In the Context of Acute Bacteremia Blood. 116: 821-821. DOI: 10.1182/Blood.V116.21.821.821 |
0.667 |
|
| 2010 |
Prasad JM, Du X, Mullins ES, Divanovic S, Talmage KE, Kombrinck KW, Cheng AG, Schneewind O, Flick MJ, Degen JL. Host Fibrinogen and the S. Aureus-Encoded Procoagulant Vwbp Are Context-Dependent Determinants of Bacterial Virulence. Blood. 116: 1152-1152. DOI: 10.1182/Blood.V116.21.1152.1152 |
0.65 |
|
| 2009 |
Yang H, Lang S, Zhai Z, Li L, Kahr WHA, Chen P, Brkić J, Spring CM, Flick MJ, Degen JL, Freedman J, Ni H. Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression Blood. 114: 425-436. PMID 19332769 DOI: 10.1182/Blood-2008-03-145821 |
0.63 |
|
| 2009 |
Shanmukhappa K, Matte U, Degen JL, Bezerra JA. Plasmin-mediated proteolysis is required for hepatocyte growth factor activation during liver repair Journal of Biological Chemistry. 284: 12917-12923. PMID 19286661 DOI: 10.1074/Jbc.M807313200 |
0.404 |
|
| 2009 |
Lian L, Wang Y, Flick M, Choi J, Scott EW, Degen J, Lemmon MA, Abrams CS. Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis. Blood. 113: 3577-84. PMID 19190246 DOI: 10.1182/Blood-2008-09-178913 |
0.619 |
|
| 2009 |
Sun H, Wang X, Degen JL, Ginsburg D. Reduced thrombin generation increases host susceptibility to group A streptococcal infection Blood. 113: 1358-1364. PMID 19056689 DOI: 10.1182/Blood-2008-07-170506 |
0.423 |
|
| 2009 |
Mullins ES, Kombrinck KW, Talmage KE, Shaw MA, Witte DP, Ullman JM, Degen SJ, Sun W, Flick MJ, Degen JL. Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain. Blood. 113: 696-704. PMID 18927430 DOI: 10.1182/Blood-2008-07-169003 |
0.794 |
|
| 2009 |
Ahamed J, Palumbo JS, Degen JL, Coller BS. Platelets Are the Major Source of Circulating TGF-β1 in Mice. Blood. 114: 4021-4021. DOI: 10.1182/Blood.V114.22.4021.4021 |
0.321 |
|
| 2009 |
Mullins ES, Talmage KE, Flick M, Kombrinck KW, Strait RT, Degen JL. Transfusion Related Acute Lung Injury (TRALI) Is Ameliorated by Genetic Elimination of Fibrin(ogen) in Mice. Blood. 114: 3189-3189. DOI: 10.1182/Blood.V114.22.3189.3189 |
0.676 |
|
| 2009 |
Flick MJ, Du X, Talmage KE, Kombrink KW, Blevins EA, Palumbo JS, Degen JL. The Virulence of S. Aureus Is Supported by Host Fibrinogen and Its Bacterial Receptor ClfA in the Context of Bacteremia. Blood. 114: 3188-3188. DOI: 10.1182/Blood.V114.22.3188.3188 |
0.673 |
|
| 2009 |
Mullins ES, Kombrinck KW, Talmage KE, Shaw MA, Witte DP, Ullman JM, Degen SJ, Sun W, Flick MJ, Degen JL. Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain Blood. 113: 696-704. DOI: 10.1182/blood-2008-07-169003 |
0.734 |
|
| 2008 |
Vidal B, Serrano AL, Tjwa M, Suelves M, Ardite E, De Mori R, Baeza-Raja B, De Lagrán MM, Lafuste P, Ruiz-Bonilla V, Jardí M, Gherardi R, Christov C, Dierssen M, Carmeliet P, ... Degen JL, et al. Fibrinogen drives dystrophic muscle fibrosis via a TGFβ/alternative macrophage activation pathway Genes and Development. 22: 1747-1752. PMID 18593877 DOI: 10.1101/Gad.465908 |
0.381 |
|
| 2008 |
Palumbo JS, Barney KA, Blevins EA, Shaw MA, Mishra A, Flick MJ, Kombrinck KW, Talmage KE, Souri M, Ichinose A, Degen JL. Factor XIII transglutaminase supports hematogenous tumor cell metastasis through a mechanism dependent on natural killer cell function Journal of Thrombosis and Haemostasis. 6: 812-819. PMID 18315549 DOI: 10.1111/J.1538-7836.2008.02938.X |
0.646 |
|
| 2008 |
Souri M, Koseki-Kuno S, Takeda N, Yamakawa M, Takeishi Y, Degen JL, Ichinose A. Male-specific cardiac pathologies in mice lacking either the A or B subunit of factor XIII Thrombosis and Haemostasis. 99: 401-408. PMID 18278192 DOI: 10.1160/Th07-10-0599 |
0.436 |
|
| 2008 |
Souri M, Koseki-Kuno S, Takeda N, Degen JL, Ichinose A. Administration of factor XIII B subunit increased plasma factor XIII A subunit levels in factor XIII B subunit knock-out mice International Journal of Hematology. 87: 60-68. PMID 18224415 DOI: 10.1007/S12185-007-0005-Z |
0.444 |
|
| 2008 |
Mullins ES, Kombrinck KW, Talmage KE, Shaw MA, Witte DP, Ullman JM, Degen SJ, Sun W, Flick M, Degen J. Genetic Elimination of Prothrombin in Adult Mice Results in Fatal Spontaneous Hemorrhage in the Heart and Central Nervous System Blood. 112: 395-395. DOI: 10.1182/Blood.V112.11.395.395 |
0.755 |
|
| 2007 |
Flick MJ, LaJeunesse CM, Talmage KE, Witte DP, Palumbo JS, Pinkerton MD, Thornton S, Degen JL. Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin αMβ2 binding motif Journal of Clinical Investigation. 117: 3224-3235. PMID 17932565 DOI: 10.1172/Jci30134 |
0.666 |
|
| 2007 |
Roszell NJ, Danton MJ, Jiang M, Witte D, Daugherty C, Grimes T, Girdler B, Anderson KP, Franco RS, Degen JL, Joiner CH. Fibrinogen deficiency, but not plasminogen deficiency, increases mortality synergistically in combination with sickle hemoglobin SAD in transgenic mice American Journal of Hematology. 82: 1044-1048. PMID 17722076 DOI: 10.1002/Ajh.20982 |
0.479 |
|
| 2007 |
Degen JL, Bugge TH, Goguen JD. Fibrin and fibrinolysis in infection and host defense Journal of Thrombosis and Haemostasis. 5: 24-31. PMID 17635705 DOI: 10.1111/J.1538-7836.2007.02519.X |
0.392 |
|
| 2007 |
Palumbo JS, Talmage KE, Massari JV, La Jeunesse CM, Flick MJ, Kombrinck KW, Hu Z, Barney KA, Degen JL. Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and -independent mechanisms Blood. 110: 133-141. PMID 17371949 DOI: 10.1182/Blood-2007-01-065995 |
0.632 |
|
| 2007 |
Adams RA, Bauer J, Flick MJ, Sikorski SL, Nuriel T, Lassmann H, Degen JL, Akassoglou K. The fibrin-derived γ377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease Journal of Experimental Medicine. 204: 571-582. PMID 17339406 DOI: 10.1084/Jem.20061931 |
0.636 |
|
| 2007 |
Zhang G, Kernan KA, Collins SJ, Cai X, López-Guisa JM, Degen JL, Shvil Y, Eddy AA. Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: Role of plasmin-activated signals Journal of the American Society of Nephrology. 18: 846-859. PMID 17267741 DOI: 10.1681/Asn.2006080886 |
0.418 |
|
| 2007 |
Mullins ES, Kombrinck KW, Flick MJ, Shaw MA, Sun W, Degen SJ, Akassoglou K, Degen JL. Reduction of Prothrombin in Mice Carrying a Conditional Knockout Allele Attenuates the Development of Paralysis Associated with Experimental Encephalitis. Blood. 110: 407-407. DOI: 10.1182/Blood.V110.11.407.407 |
0.791 |
|
| 2007 |
Flick MJ, Chauhan AK, Welch S, Shaw MA, Talmage KE, Mullins ES, Palumbo JS, Thornton S, Wagner DD, Degen JL. Mice Engineered To Express a Form of Thrombin Favoring Protein C Are Resistant to S. aureus-Induced Sepsis. Blood. 110: 267-267. DOI: 10.1182/Blood.V110.11.267.267 |
0.71 |
|
| 2007 |
Palumbo JS, Barney KA, Williams EA, Shaw MA, Mishra A, Flick MJ, Talmage KE, Degen JL. Factor XIII Supports Metastatic Potential through a Mechanism Coupled to Natural Killer Cell Function. Blood. 110: 1753-1753. DOI: 10.1182/Blood.V110.11.1753.1753 |
0.665 |
|
| 2007 |
Wang Y, Lian L, Flick M, Degen J, Lemmon M, Abrams CS. Mice Lacking Pleckstrin or Pleckstrin-2 Each Have Unique Platelet Secretion Defects. Blood. 110: 134-134. DOI: 10.1182/Blood.V110.11.134.134 |
0.62 |
|
| 2006 |
Shanmukhappa K, Sabla GE, Degen JL, Bezerra JA. Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor Bmc Gastroenterology. 6. PMID 17134505 DOI: 10.1186/1471-230X-6-40 |
0.399 |
|
| 2006 |
Palumbo J, Barney KA, Flick MJ, Talmage KE, Kombrinck KW, Hu Z, La Jeunesse CM, Degen JL. Tumor Cell-Associated Tissue Factor Supports Metastatic Potential through Both NK Cell-Dependent and -Independent Mechanisms. Blood. 108: 66-66. DOI: 10.1182/Blood.V108.11.66.66 |
0.628 |
|
| 2006 |
Flick MJ, La Jeunesse CM, Talmage KE, Witte DP, Palumbo J, Pinkerton MD, Thornton S, Degen JL. Fibrin(ogen) Exacerbates Inflammatory Joint Disease Via a Mechanism Linked to Its αMβ2 Binading Motif. Blood. 108: 64-64. DOI: 10.1182/Blood.V108.11.64.64 |
0.673 |
|
| 2006 |
Lian L, Wang Y, Chen X, Bach T, Lenox L, Zhu P, Flick M, Scott E, Degen J, Freedman B, Koretzky G, Lemmon M, Abrams CS. Knockout of the PKC Substrate Pleckstrin Causes Pleomorphic Defects in Platelets, Lymphocytes and Granulocytes. Blood. 108: 394-394. DOI: 10.1182/Blood.V108.11.394.394 |
0.635 |
|
| 2006 |
Mullins ES, Flick MJ, Kombrinck KW, Degen SJ, Sun W, Degen JL. Conditional Disruption of the Murine Prothrombin Gene. Blood. 108: 1600-1600. DOI: 10.1182/Blood.V108.11.1600.1600 |
0.808 |
|
| 2006 |
Flick M, Welch S, La Jeunesse C, Talmage K, Mullins E, Palumbo J, Thornton S, Degen J. ID: 097 Mice expressing a thrombin variant engineered to favor anticoagulant function are resistant to S. aureus-induced sepsis Journal of Thrombosis and Haemostasis. 4: 115-115. DOI: 10.1111/J.1538-7836.2006.00097.X |
0.631 |
|
| 2006 |
Adams R, Bauer J, Sikorski S, Nuriel T, Flick M, Lassmann H, Degen J, Akassoglou K. ID: 071 Fibrin/Mac-1 interactions induce microglia activation and regulate relapsing paralysis in central nervous system autoimmune disease Journal of Thrombosis and Haemostasis. 4: 133-133. DOI: 10.1111/J.1538-7836.2006.00071.X |
0.577 |
|
| 2005 |
Shanmukhappa K, Mourya R, Sabla GE, Degen JL, Bezerra JA. Hepatic to pancreatic switch defines a role for hemostatic factors in cellular plasticity in mice Proceedings of the National Academy of Sciences of the United States of America. 102: 10182-10187. PMID 16006527 DOI: 10.1073/Pnas.0501691102 |
0.421 |
|
| 2005 |
Palumbo JS, Talmage KE, Massari JV, La Jeunesse CM, Flick MJ, Kombrinck KW, Jirousková M, Degen JL. Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells Blood. 105: 178-185. PMID 15367435 DOI: 10.1182/Blood-2004-06-2272 |
0.647 |
|
| 2005 |
Palumbo JS, Massari JV, La Jeunesse CM, Flick MJ, Hu Z, Talmage KE, Degen JL. Interplay between Tumor Cell-Associated and Circulating Coagulation Factors in Establishing Metastatic Potential. Blood. 106: 686-686. DOI: 10.1182/Blood.V106.11.686.686 |
0.627 |
|
| 2005 |
Flick MJ, Du X, Talmage KE, LaJeunesse CM, Witte DP, Palumbo JS, Degen JL. Hemostatic Factors Regulate Immune Surveillance and Contribute to the Rapid Clearance of Bacterial Pathogens In Vivo. Blood. 106: 2132-2132. DOI: 10.1182/Blood.V106.11.2132.2132 |
0.701 |
|
| 2004 |
Flick MJ, Du X, Degen JL. Fibrin(ogen)-αMβ2 interactions regulate leukocyte function and innate immunity in vivo Experimental Biology and Medicine. 229: 1105-1110. PMID 15564436 DOI: 10.1177/153537020422901104 |
0.621 |
|
| 2004 |
Tucker HM, Simpson J, Kihiko-Ehmann M, Younkin LH, McGillis JP, Younkin SG, Degen JL, Estus S. Plasmin deficiency does not alter endogenous murine amyloid beta levels in mice. Neuroscience Letters. 368: 285-9. PMID 15364412 DOI: 10.1016/J.Neulet.2004.07.011 |
0.321 |
|
| 2004 |
Palumbo JS, Zogg M, Talmage KE, Degen JL, Weiler H, Isermann BH. Role of fibrinogen- and platelet-mediated hemostasis in mouse embryogenesis and reproduction Journal of Thrombosis and Haemostasis. 2: 1368-1379. PMID 15304043 DOI: 10.1111/J.1538-7836.2004.00788.X |
0.449 |
|
| 2004 |
Flick MJ, Du X, Witte DP, Jiroušková M, Soloviev DA, Busuttil SJ, Plow EF, Degen JL. Leukocyte engagement of fibrin(ogen) via the integrin receptor αMβ2/Mac-1 is critical for host inflammatory response in vivo Journal of Clinical Investigation. 113: 1596-1606. PMID 15173886 DOI: 10.1172/Jci20741 |
0.599 |
|
| 2004 |
Jiroušková M, Chereshnev I, Väänänen H, Degen JL, Coller BS. Antibody blockade or mutation of the fibrinogen γ-chain C-terminus is more effective in inhibiting murine arterial thrombus formation than complete absence of fibrinogen Blood. 103: 1995-2002. PMID 14644995 DOI: 10.1182/Blood-2003-10-3401 |
0.483 |
|
| 2004 |
Palumbo JS, Talmage KE, Massari JV, La Jeunesse CM, Flick MJ, Jirouskova M, Degen JL. Hemostatic Factors Contribute to Tumor Cell Metastatic Potential by a Mechanism Linked to Natural Killer Cell Function. Blood. 104: 690-690. DOI: 10.1182/Blood.V104.11.690.690 |
0.665 |
|
| 2003 |
Degen JL, Palumbo JS. Mechanisms linking hemostatic factors to tumor growth in mice Pathophysiology of Haemostasis and Thrombosis. 33: 31-35. PMID 12954998 DOI: 10.1159/000073287 |
0.403 |
|
| 2003 |
Ni H, Papalia JM, Degen JL, Wagner DD. Control of thrombus embolization and fibronectin internalization by integrin alpha IIb beta 3 engagement of the fibrinogen gamma chain. Blood. 102: 3609-14. PMID 12855554 DOI: 10.1182/Blood-2003-03-0850 |
0.4 |
|
| 2003 |
Palumbo JS, Talmage KE, Liu H, La Jeunesse CM, Witte DP, Degen JL. Plasminogen supports tumor growth through a fibrinogen-dependent mechanism linked to vascular patency. Blood. 102: 2819-27. PMID 12829586 DOI: 10.1182/Blood-2003-03-0881 |
0.387 |
|
| 2003 |
Kufrin D, Eslin DE, Bdeir K, Murciano JC, Kuo A, Kowalska MA, Degen JL, Sachais BS, Cines DB, Poncz M. Antithrombotic thrombocytes: Ectopic expression of urokinase-type plasminogen activator in platelets Blood. 102: 926-933. PMID 12689937 DOI: 10.1182/Blood-2003-01-0054 |
0.423 |
|
| 2003 |
Isermann B, Sood R, Pawlinski R, Zogg M, Kalloway S, Degen JL, Mackman N, Weiler H. The thrombomodulin-protein C system is essential for the maintenance of pregnancy Nature Medicine. 9: 331-337. PMID 12579195 DOI: 10.1038/Nm825 |
0.35 |
|
| 2003 |
Currier AR, Sabla G, Locaputo S, Melin-Aldana H, Degen JL, Bezerra JA. Plasminogen directs the pleiotropic effects of uPA in liver injury and repair American Journal of Physiology - Gastrointestinal and Liver Physiology. 284: G508-G515. PMID 12431907 DOI: 10.1152/Ajpgi.00336.2002 |
0.394 |
|
| 2003 |
Shanmukhappa K, Sabla G, Degen JL, Bezerra JA. Plasminogen deficiency results in a pancreatic switch during liver repair in adult mice Gastroenterology. 124: A21. DOI: 10.1016/S0016-5085(03)80106-3 |
0.404 |
|
| 2001 |
Ng VL, Sabla GE, Melin-Aldana H, Kelley-Loughnane N, Degen JL, Bezerra JA. Plasminogen deficiency results in poor clearance of non-fibrin matrix and persistent activation of hepatic stellate cells after an acute injury Journal of Hepatology. 35: 781-789. PMID 11738106 DOI: 10.1016/S0168-8278(01)00212-4 |
0.41 |
|
| 2001 |
Pohl JF, Melin-Aldana H, Sabla G, Degen JL, Bezerra JA. Plasminogen deficiency leads to impaired lobular reorganization and matrix accumulation after chronic liver injury American Journal of Pathology. 159: 2179-2186. PMID 11733368 DOI: 10.1016/S0002-9440(10)63069-6 |
0.344 |
|
| 2001 |
Drew AF, Tucker HL, Liu H, Witte DP, Degen JL, Tipping PG. Crescentic glomerulonephritis is diminished in fibrinogen-deficient mice American Journal of Physiology - Renal Physiology. 281: F1157-F1163. PMID 11704568 DOI: 10.1152/Ajprenal.0002.2001 |
0.486 |
|
| 2001 |
Degen JL. Genetic interactions between the coagulation and fibrinolytic systems Thrombosis and Haemostasis. 86: 130-137. PMID 11486998 DOI: 10.1055/S-0037-1616209 |
0.473 |
|
| 2001 |
Degen JL, Drew AF, Palumbo JS, Kombrinck KW, Bezerra JA, Danton MJOS, Holmbäck K, Suh TT. Genetic manipulation of fibrinogen and fibrinolysis in mice Annals of the New York Academy of Sciences. 936: 276-290. PMID 11460484 DOI: 10.1111/J.1749-6632.2001.Tb03515.X |
0.47 |
|
| 2001 |
Drew AF, Liu H, Davidson JM, Daugherty CC, Degen JL. Wound-healing defects in mice lacking fibrinogen. Blood. 97: 3691-8. PMID 11389004 DOI: 10.1182/Blood.V97.12.3691 |
0.439 |
|
| 2001 |
Bezerra JA, Currier AR, Melin-Aldana H, Sabla G, Bugge TH, Kombrinck KW, Degen JL. Plasminogen activators direct reorganization of the liver lobule after acute injury American Journal of Pathology. 158: 921-929. PMID 11238040 DOI: 10.1016/S0002-9440(10)64039-4 |
0.4 |
|
| 2000 |
Weglarz TC, Degen JL, Sandgren EP. Hepatocyte transplantation into diseased mouse liver: Kinetics of parenchymal repopulation and identification of the proliferative capacity of tetraploid and octaploid hepatocytes American Journal of Pathology. 157: 1963-1974. PMID 11106569 DOI: 10.1016/S0002-9440(10)64835-3 |
0.38 |
|
| 2000 |
Hattori N, Degen JL, Sisson TH, Liu H, Moore BB, Pandrangi RG, Simon RH, Drew AF. Bleomycin-induced pulmonary fibrosis in fibrinogen-null mice Journal of Clinical Investigation. 106: 1341-1350. PMID 11104787 DOI: 10.1172/Jci10531 |
0.476 |
|
| 2000 |
Palumbo JS, Kombrinck KW, Drew AF, Grimes TS, Kiser JH, Degen JL, Bugge TH. Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells Blood. 96: 3302-3309. PMID 11071621 DOI: 10.1182/Blood.V96.10.3302.H8003302_3302_3309 |
0.35 |
|
| 2000 |
Ni H, Denis CV, Subbarao S, Degen JL, Sato TN, Hynes RO, Wagner DD. Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen. The Journal of Clinical Investigation. 106: 385-92. PMID 10930441 DOI: 10.1172/Jci9896 |
0.483 |
|
| 2000 |
Drew AF, Tucker HL, Kombrinck KW, Simon DI, Bugge TH, Degen JL. Plasminogen is a critical determinant of vascular remodeling in mice Circulation Research. 87: 133-139. PMID 10903997 DOI: 10.1161/01.Res.87.2.133 |
0.437 |
|
| 2000 |
Akassoglou K, Kombrinck KW, Degen JL, Strickland S. Tissue plasminogen activator-mediated fibrinolysis protects against axonal degeneration and demyelination after sciatic nerve injury Journal of Cell Biology. 149: 1157-1166. PMID 10831618 DOI: 10.1083/Jcb.149.5.1157 |
0.328 |
|
| 2000 |
Goguen JD, Bugge T, Degen JL. Role of the pleiotropic effects of plasminogen deficiency in infection experiments with plasminogen-deficient mice Methods. 21: 179-183. PMID 10816379 DOI: 10.1006/meth.2000.0989 |
0.41 |
|
| 2000 |
Wu YP, Siao CJ, Lu W, Sung TC, Frohman MA, Milev P, Bugge TH, Degen JL, Levine JM, Margolis RU, Tsirka SE. The tissue plasminogen activator (tPA)/plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrate. The Journal of Cell Biology. 148: 1295-304. PMID 10725341 DOI: 10.1083/Jcb.148.6.1295 |
0.311 |
|
| 2000 |
Drew AF, Schiman HL, Kombrinck KW, Bugge TH, Degen JL, Kaufman AH. Persistent corneal haze after excimer laser photokeratectomy in plasminogen-deficient mice Investigative Ophthalmology and Visual Science. 41: 67-72. PMID 10634603 |
0.345 |
|
| 2000 |
Pohl JF, Melin-Aldana H, Sabla G, Degen JL, Bezerra JA. Plasminogen deficiency accelerates the development of hepatic fibrosis in mice Gastroenterology. 118: A989. DOI: 10.1016/S0016-5085(00)86103-X |
0.439 |
|
| 1999 |
Bezerra JA, Bugge TH, Melin-Aldana H, Sabla G, Kombrinck KW, Witte DP, Degen JL. Plasminogen deficiency leads to impaired remodeling after a toxic injury to the liver Proceedings of the National Academy of Sciences of the United States of America. 96: 15143-15148. PMID 10611352 DOI: 10.1073/Pnas.96.26.15143 |
0.356 |
|
| 1999 |
Degen JL. Hemostatic factors and inflammatory disease Thrombosis and Haemostasis. 82: 858-864. PMID 10605794 DOI: 10.1055/S-0037-1615923 |
0.409 |
|
| 1999 |
Chen ZL, Indyk JA, Bugge TH, Kombrinck KW, Degen JL, Strickland S. Neuronal death and blood-brain barrier breakdown after excitotoxic injury are independent processes Journal of Neuroscience. 19: 9813-9820. PMID 10559390 DOI: 10.1523/Jneurosci.19-22-09813.1999 |
0.384 |
|
| 1999 |
Lund LR, Rømer J, Bugge TH, Nielsen BS, Frandsen TL, Degen JL, Stephens RW, Danø K. Functional overlap between two classes of matrix-degrading proteases in wound healing Embo Journal. 18: 4645-4656. PMID 10469644 DOI: 10.1093/Emboj/18.17.4645 |
0.399 |
|
| 1999 |
Muraoka RS, Sun WY, Colbert MC, Waltz SE, Witte DP, Degen JL, Degen SJF. The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse Journal of Clinical Investigation. 103: 1277-1285. PMID 10225971 DOI: 10.1172/Jci6091 |
0.432 |
|
| 1999 |
Gebbia JA, Garcia Monco JC, Degen JL, Bugge TH, Benach JL. The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis Journal of Clinical Investigation. 103: 81-87. PMID 9884337 DOI: 10.1172/Jci5171 |
0.455 |
|
| 1998 |
Lou XJ, Boonmark NW, Horrigan FT, Degen JL, Lawn RM. Fibrinogen deficiency reduces vascular accumulation of apolipoprotein(a) and development of atherosclerosis in apolipoprotein(a) transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 95: 12591-5. PMID 9770530 DOI: 10.1073/Pnas.95.21.12591 |
0.472 |
|
| 1998 |
Bugge TH, Lund LR, Kombrinck KK, Nielsen BS, Holmbäck K, Drew AF, Flick MJ, Witte DP, Danø K, Degen JL. Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice Oncogene. 16: 3097-3104. PMID 9671388 DOI: 10.1038/Sj.Onc.1201869 |
0.649 |
|
| 1998 |
Busso N, Péclat V, Van Ness K, Kolodziesczyk E, Degen J, Bugge T, So A. Exacerbation of antigen-induced arthritis in urokinase-deficient mice Journal of Clinical Investigation. 102: 41-50. PMID 9649555 |
0.383 |
|
| 1998 |
Sun WY, Witte DP, Degen JL, Colbert MC, Burkart MC, Holmbäck K, Xiao Q, Bugge TH, Degen SJF. Prothrombin deficiency results in embryonic and neonatal lethality in mice Proceedings of the National Academy of Sciences of the United States of America. 95: 7597-7602. PMID 9636195 DOI: 10.1073/Pnas.95.13.7597 |
0.488 |
|
| 1998 |
Kao WWY, Kao CWC, Kaufman AH, Kombrinck KW, Converse RL, Good WV, Bugge TH, Degen JL. Healing of corneal epithelial defects in plasminogen-and fibrinogen- deficient mice Investigative Ophthalmology and Visual Science. 39: 502-508. PMID 9501859 |
0.364 |
|
| 1998 |
Xiao Q, Danton MJS, Witte DP, Kowala MC, Valentine MT, Degen JL. Fibrinogen deficiency is compatible with the development of atherosclerosis in mice Journal of Clinical Investigation. 101: 1184-1194. PMID 9486990 DOI: 10.1172/Jci1461 |
0.448 |
|
| 1998 |
Bezerra JA, Carrick TL, Degen JL, Witte D, Degen SJF. Biological effects of targeted inactivation of hepatocyte growth factor- like protein in mice Journal of Clinical Investigation. 101: 1175-1183. PMID 9486989 DOI: 10.1172/Jci1744 |
0.509 |
|
| 1998 |
Drew AF, Kaufman AH, Kombrinck KW, Danton MJS, Daugherty CC, Degen JL, Bugge TH. Ligneous conjunctivitis in plasminogen-deficient mice Blood. 91: 1616-1624. PMID 9473227 DOI: 10.1182/Blood.V91.5.1616.1616_1616_1624 |
0.478 |
|
| 1997 |
Bugge TH, Kombrinck KW, Xiao Q, Holmbäck K, Daugherty CC, Witte DP, Degen JL. Growth and dissemination of Lewis lung carcinoma in plasminogen- deficient mice Blood. 90: 4522-4531. PMID 9373263 DOI: 10.1182/Blood.V90.11.4522.4522_4522_4531 |
0.486 |
|
| 1997 |
Xiao Q, Danton MJS, Witte DP, Kowala MC, Valentine MT, Bugge TH, Degen JL. Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosis Proceedings of the National Academy of Sciences of the United States of America. 94: 10335-10340. PMID 9294211 DOI: 10.1073/Pnas.94.19.10335 |
0.452 |
|
| 1997 |
Tsirka SE, Bugge TH, Degen JL, Strickland S. Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin Proceedings of the National Academy of Sciences of the United States of America. 94: 9779-9781. PMID 9275201 DOI: 10.1073/Pnas.94.18.9779 |
0.482 |
|
| 1997 |
Coleman JL, Gebbia JA, Piesman J, Degen JL, Bugge TH, Benach JL. Plasminogen is required for efficient dissemination of B. burgdorferi in ticks and for enhancement of spirochetemia in mice Cell. 89: 1111-1119. PMID 9215633 DOI: 10.1016/S0092-8674(00)80298-6 |
0.405 |
|
| 1997 |
Tsirka SE, Rogove AD, Bugge TH, Degen JL, Strickland S. An extracellular proteolytic cascade promotes neuronal degeneration in the mouse hippocampus Journal of Neuroscience. 17: 543-552. PMID 8987777 DOI: 10.1523/Jneurosci.17-02-00543.1997 |
0.402 |
|
| 1997 |
Degen JL, Xiao Q, Bugge aTH. Haemostasis and thrombosis in mice with genetic deficits in coagulation and fibrinolysis Blood Coagulation & Fibrinolysis. 8: 472. DOI: 10.1097/00001721-199710000-00040 |
0.319 |
|
| 1997 |
Bugge TH, Lund LR, Kombrinck KK, Nielsen BS, Holmbäck K, Drew AF, Flick MJ, Witte DP, Danø K, Degen JL. 82 Reduced breast cancer metastasis in plasminogen-deficient mice Fibrinolysis and Proteolysis. 11: 24. DOI: 10.1016/S0268-9499(97)80198-1 |
0.617 |
|
| 1997 |
Drew AF, Kaufman AH, Kombrinck KW, Daugherty CC, Degen JL, Bugge TH. 72 Ligneous conjunctivitis in plasminogen-deficient mice Fibrinolysis and Proteolysis. 11: 21. DOI: 10.1016/S0268-9499(97)80188-9 |
0.491 |
|
| 1997 |
Kao WWY, Kao CWC, Kombrinck KW, Converse RL, Good WV, Kaufman AH, Bugge TH, Degen JL. Healing of corneal epithelial defects in plasminogenand fibrinogen -deficient mice Fibrinolysis and Proteolysis. 11: 20. DOI: 10.1016/S0268-9499(97)80187-7 |
0.465 |
|
| 1997 |
Bjørn S, Lund L, Bugge I, Christensen I, Østerby R, Degen J, Werb Z, Danø K. 68 Impairment of post-lactational involution of the mammary gland in mice deficient for the plasminogen gene Fibrinolysis and Proteolysis. 11: 19. DOI: 10.1016/S0268-9499(97)80183-X |
0.455 |
|
| 1997 |
Bugge TH, Danton MJS, Dang K, Daugherty CC, Drew A, Flick MJ, Holmbäck K, Kaol W, Kombrinck KW, Lund LR, Pyke C, Romcr J, Strickland S, Tsirka SE, Xiaoli Q, ... Degen JL, et al. Biological roles and substrates of plasmin in the mouse Faseb Journal. 11: A1444. |
0.536 |
|
| 1996 |
Bugge TH, Kombrinck KW, Flick MJ, Daugherty CC, Danton MJS, Degen JL. Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency Cell. 87: 709-719. PMID 8929539 DOI: 10.1016/S0092-8674(00)81390-2 |
0.703 |
|
| 1996 |
Holmbäck K, Danton MJ, Suh TT, Daugherty CC, Degen JL. Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin alpha IIb beta 3. The Embo Journal. 15: 5760-71. PMID 8918453 DOI: 10.1002/J.1460-2075.1996.Tb00962.X |
0.371 |
|
| 1996 |
Bugge TH, Xiao Q, Kombrinck KW, Flick MJ, Holmback K, Danton MJS, Colbert MC, Witte DP, Fujikawa K, Davie EW, Degen JL. Fatal embryonic bleeding events in mice lacking tissue factor, the cell- associated initiator of blood coagulation Proceedings of the National Academy of Sciences of the United States of America. 93: 6258-6263. PMID 8692802 DOI: 10.1073/Pnas.93.13.6258 |
0.678 |
|
| 1996 |
Romer J, Bugge TH, Pyke C, Lund LR, Flick MJ, Degen JL, Dano K, Thompson WD, Stirk CM, Melvin WT, Smith EB. Plasminogen and wound healing [5] Nature Medicine. 2: 725. PMID 8673908 DOI: 10.1038/Nm0796-725A |
0.541 |
|
| 1996 |
Bugge TH, Flick MJ, Danton MJ, Daugherty CC, Romer J, Dano K, Carmeliet P, Collen D, Degen JL. Urokinase-type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-type plasminogen activator. Proceedings of the National Academy of Sciences of the United States of America. 93: 5899-904. PMID 8650190 DOI: 10.1073/Pnas.93.12.5899 |
0.7 |
|
| 1996 |
Romer J, Bugge TH, Pyke C, Lund LR, Flick MJ, Degen JL, Dano K. Impaired wound healing in mice with a disrupted plasminogen gene. Nature Medicine. 2: 287-92. PMID 8612226 DOI: 10.1038/Nm0396-287 |
0.647 |
|
| 1996 |
Bugge TH, Flick MJ, Danton MJS, Daugherty CC, Rømer J, Danø K, Carmeliet P, Collen D, Degen JL. Urokinase-Type plasminogen activator is effective in fibrin clearance in the absence of its receptor or tissue-Type plasminogen activator Fibrinolysis. 10: 79. DOI: 10.1073/pnas.93.12.5899 |
0.526 |
|
| 1996 |
Bugge TH, Kombrinck K, Flick MJ, Daugherty CC, Mjs D, Degen JL. Complete rescue of the pleiotropic effects of plasminogen-deficiency by fibrinogen-deficiency Fibrinolysis. 10: 19. |
0.571 |
|
| 1996 |
Degen JL, Xiao Q, Kombrinck K, Flick MJ, Holmbäck K, Mjs D, Colbert MC, Witte DP, Fujikawa K, Davie EW, Bugge TH. Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation Fibrinolysis. 10: 19. |
0.623 |
|
| 1996 |
Bugge TH, Lund LR, Kombrinck KW, Flick MJ, Degen JL. Metastatic mammary tumors in plasminogen-deficient mice Fibrinolysis. 10: 79. |
0.632 |
|
| 1996 |
Rømer J, Bugge T, Pyke C, Lund LR, Flick MJ, Degen JL, Danø K. Impaired wound healing in mice with a disrupted plasminogen gene Fibrinolysis. 10: 78. |
0.616 |
|
| 1996 |
Degen JL, Rømer J, Lund LR, Kombrinck K, Danø K, Bugge TH. Efficient wound healing despite an altered pattern of keratinocyte migration in fibrinogen-deficient mice Fibrinolysis. 10: 79. |
0.32 |
|
| 1996 |
Rømer J, Bugge T, Pyke C, Lund LR, Flick MJ, Degen JL, Danø K. Impaired wound healing in mice with a disrupted plasminogen gene Fibrinolysis. 10: 78. |
0.616 |
|
| 1995 |
Bugge TH, Flick MJ, Daugherty CC, Degen JL. Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction Genes and Development. 9: 794-807. PMID 7705657 DOI: 10.1101/Gad.9.7.794 |
0.698 |
|
| 1995 |
Suh TT, Holmbäck K, Jensen NJ, Daugherty CC, Small K, Simon DI, Potter S, Degen JL. Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice. Genes & Development. 9: 2020-33. PMID 7649481 DOI: 10.1101/Gad.9.16.2020 |
0.414 |
|
| 1995 |
Bugge TH, Suh TT, Flick MJ, Daugherty CC, Romer J, Solberg H, Ellis V, Dano K, Degen JL. The receptor for urokinase-type plasminogen activator is not essential for mouse development or fertility Journal of Biological Chemistry. 270: 16886-16894. PMID 7622505 DOI: 10.1074/Jbc.270.28.16886 |
0.709 |
|
| 1994 |
Carmeliet P, Schoonjans L, Kieckens L, Ream B, Degen J, Bronson R, De Vos R, van den Oord JJ, Collen D, Mulligan RC. Physiological consequences of loss of plasminogen activator gene function in mice. Nature. 368: 419-24. PMID 8133887 DOI: 10.1038/368419A0 |
0.382 |
|
| 1994 |
Degen JL, Jensen NJ, Daugherty CC, McLain K, Steven Potter S, Suhl TT. Fibrinogen-deficient transgenic mice Fibrinolysis. 8: 102. DOI: 10.1016/0268-9499(94)90569-X |
0.489 |
|
| 1992 |
Clegg CH, Abrahamsen MS, Degen JL, Morris DR, McKnight GS. Cyclic AMP-dependent protein kinase controls basal gene activity and steroidogenesis in Y1 adrenal tumor cells. Biochemistry. 31: 3720-6. PMID 1567825 |
0.443 |
|
| 1992 |
Sandgren EP, Palmiter RD, Heckel JL, Brinster RL, Degen JL. DNA rearrangement causes hepatocarcinogenesis in albumin-plasminogen activator transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 89: 11523-7. PMID 1454842 DOI: 10.1073/Pnas.89.23.11523 |
0.443 |
|
| 1991 |
Sandgren EP, Palmiter RD, Heckel JL, Daugherty CC, Brinster RL, Degen JL. Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene. Cell. 66: 245-56. PMID 1713128 DOI: 10.1016/0092-8674(91)90615-6 |
0.412 |
|
| 1990 |
Heckel JL, Sandgren EP, Degen JL, Palmiter RD, Brinster RL. Neonatal bleeding in transgenic mice expressing urokinase-type plasminogen activator. Cell. 62: 447-56. PMID 1696178 DOI: 10.1016/0092-8674(90)90010-C |
0.487 |
|
| 1987 |
Degen SJ, Heckel JL, Reich E, Degen JL. The murine urokinase-type plasminogen activator gene. Biochemistry. 26: 8270-9. PMID 2831940 DOI: 10.1021/Bi00399A038 |
0.688 |
|
| 1986 |
Mach M, White MW, Neubauer M, Degen JL, Morris DR. Isolation of a cDNA clone encoding S-adenosylmethionine decarboxylase. Expression of the gene in mitogen-activated lymphocytes. The Journal of Biological Chemistry. 261: 11697-703. PMID 3017942 |
0.41 |
|
| 1985 |
Degen JL, Estensen RD, Nagamine Y, Reich E. Induction and desensitization of plasminogen activator gene expression by tumor promoters. The Journal of Biological Chemistry. 260: 12426-33. PMID 3862668 |
0.454 |
|
| 1983 |
Kyte J, Degen J, Harkins RN. Purification of peptides that contain methionine residues. Methods in Enzymology. 91: 367-77. PMID 6304453 DOI: 10.1016/S0076-6879(83)91034-0 |
0.692 |
|
| 1983 |
Degen JL, Neubauer MG, Degen SJ, Seyfried CE, Morris DR. Regulation of protein synthesis in mitogen-activated bovine lymphocytes. Analysis of actin-specific and total mRNA accumulation and utilization. The Journal of Biological Chemistry. 258: 12153-62. PMID 6195151 |
0.662 |
|
| 1982 |
Seyfried CE, Oleinik OE, Degen JL, Resing K, Morris DR. Purification, properties and regulation of the level of bovine S-adenosylmethionine decarboxylase during lymphocyte mitogenesis. Biochimica Et Biophysica Acta. 716: 169-77. PMID 7093308 DOI: 10.1016/0304-4165(82)90265-3 |
0.482 |
|
| 1981 |
Morris DR, Degen JL, Oleinik OE, Seyfried CE. Regulation of the level of S-adenosylmethionine decarboxylase during lymphocyte mitogenesis. Medical Biology. 59: 314-9. PMID 7339298 |
0.423 |
|
| 1980 |
Degen JL, Morris DR. Activation of early enzyme production in small lymphocytes in response to high, nonmitogenic concentrations of concanavalin A. Proceedings of the National Academy of Sciences of the United States of America. 77: 3479-83. PMID 6932033 DOI: 10.1073/Pnas.77.6.3479 |
0.487 |
|
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