Yair Reisner - US grants

Affiliations:

IMM Immunology

Weizmann Institute of Science, Rehovot, Israel

Area:

Immunology, Cell Biology

Tree Info Publications Similar researchers PubMed Report error

We are testing a new system for linking grants to scientists.

The funding information displayed below comes from the NIH Research Portfolio Online Reporting Tools and the NSF Award Database.
The grant data on this page is limited to grants awarded in the United States and is thus partial. It can nonetheless be used to understand how funding patterns influence mentorship networks and vice-versa, which has deep implications on how research is done.
You can help! If you notice any innacuracies, please sign in and mark grants as correct or incorrect matches.

Sign in to see low-probability grants and correct any errors in linkage between grants and researchers.

High-probability grants

According to our matching algorithm, Yair Reisner is the likely recipient of the following grants.

Years	Recipients	Code	Title / Keywords	Matching score
1998 — 2002	Reisner, Yair	P01Activity Code Description: For the support of a broadly based, multidisciplinary, often long-term research program which has a specific major objective or a basic theme. A program project generally involves the organized efforts of relatively large groups, members of which are conducting research projects designed to elucidate the various aspects or components of this objective. Each research project is usually under the leadership of an established investigator. The grant can provide support for certain basic resources used by these groups in the program, including clinical components, the sharing of which facilitates the total research effort. A program project is directed toward a range of problems having a central research focus, in contrast to the usually narrower thrust of the traditional research project. Each project supported through this mechanism should contribute or be directly related to the common theme of the total research effort. These scientifically meritorious projects should demonstrate an essential element of unity and interdependence, i.e., a system of research activities and projects directed toward a well-defined research program goal.	Tolerance Induction by Megadose Stem Cell Transplants in Cml--Gvhd and Gvl @ University of Texas Md Anderson Can Ctr The overall objective of our proposed project is to develop improved approaches for allogeneic bone marrow transplantation (BMT) in chronic myeloid leukemia (CML) patients, primarily by using the megadose CD34 hematopoietic stem cell transplants supplemented with donor non- alloreactive T-cells. The hypothesis to be tested in this project is that toxicity of current conditioning regimens can be reduced by this approach, as it us anticipated that in patients conditioned by a sub-lethal protocol, infusion of hematopoietic progenitors and non-alloreactive T- cells will result in the induction of antigen-specific tolerance, and thereby diminish rejection and enhance long-term engraftment of the donor cells. Within this context, a second major objective of our project is to study how and what types of cells within the megadose CD34 stem cell transplants "paralyze" specifically the significant anti-donor residual immunity which survive the sub-lethal conditioning of the host. TO achieve our overall goal, we will conduct studies in vitro and in mouse models in close coordination with the clinical program (Project #2), to optimize the most suitable sub-lethal conditioning protocol, as well as the appropriate dose of T cell depleted stem cell enriched inoculum, to be used for transplantation. In anticipation of potential difficulty in achieving he minimal stem cell dose that might be required, we shall explore in the mouse model the synergistic role of non-alloreactive T cells, as well as search new means to generate such cells. We hope that if the overall objective of the proposed project will be achieved, it will allow to join forces with another study of the Program Project aiming at developing donor type anti-leukemic CTL clones, as such cells could be adoptively transferred to the patients following the establishment of tolerance towards donor type cells. Show summary Hide summary	0.907
2008	Reisner, Yair	U19Activity Code Description: To support a research program of multiple projects directed toward a specific major objective, basic theme or program goal, requiring a broadly based, multidisciplinary and often long-term approach. A cooperative agreement research program generally involves the organized efforts of large groups, members of which are conducting research projects designed to elucidate the various aspects of a specific objective. Substantial Federal programmatic staff involvement is intended to assist investigators during performance of the research activities, as defined in the terms and conditions of award. The investigators have primary authorities and responsibilities to define research objectives and approaches, and to plan, conduct, analyze, and publish results, interpretations and conclusions of their studies. Each research project is usually under the leadership of an established investigator in an area representing his/her special interest and competencies. Each project supported through this mechanism should contribute to or be directly related to the common theme of the total research effort. The award can provide support for certain basic shared resources, including clinical components, which facilitate the total research effort. These scientifically meritorious projects should demonstrate an essential element of unity and interdependence.	Reducing Conditioning Through Control of Host Anti-Donor Alloreactivity @ Dana-Farber Cancer Institute	0.94