Daniela C. Zarnescu

Affiliations: 
University of Arizona, Tucson, AZ 
Area:
neural development, cell polarity, RNA transport
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"Daniela Zarnescu"

Parents

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Graham Thomas grad student 1995-2000 Penn State
Kevin Moses post-doc 2000-2005
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Publications

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Bjork RT, Mortimore NP, Loganathan S, et al. (2022) Dysregulation of Translation in TDP-43 Proteinopathies: Deficits in the RNA Supply Chain and Local Protein Production. Frontiers in Neuroscience. 16: 840357
Lehmkuhl EM, Loganathan S, Alsop E, et al. (2021) TDP-43 proteinopathy alters the ribosome association of multiple mRNAs including the glypican Dally-like protein (Dlp)/GPC6. Acta Neuropathologica Communications. 9: 52
Loganathan S, Lehmkuhl EM, Eck RJ, et al. (2019) To Be or Not To Be…Toxic-Is RNA Association With TDP-43 Complexes Deleterious or Protective in Neurodegeneration? Frontiers in Molecular Biosciences. 6: 154
Francois-Moutal L, Scott DD, Felemban R, et al. (2019) A small molecule targeting TDP-43's RNA recognition motifs reduces locomotor defects in a Drosophila model of ALS. Acs Chemical Biology
Manzo E, Lorenzini I, Barrameda D, et al. (2019) Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS. Elife. 8
Lehmkuhl EM, Zarnescu DC. (2018) Lost in Translation: Evidence for Protein Synthesis Deficits in ALS/FTD and Related Neurodegenerative Diseases. Advances in Neurobiology. 20: 283-301
Ferro D, Yao S, Zarnescu DC. (2018) Dynamic duo - FMRP and TDP-43: regulating common targets, causing different diseases. Brain Research
Chou CC, Zhang Y, Umoh ME, et al. (2018) TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD. Nature Neuroscience
Daniel SG, Russ AD, Guthridge KM, et al. (2017) miR-9a mediates the role of Lethal giant larvae as an epithelial growth inhibitor in Drosophila. Biology Open
Liu G, Coyne AN, Pei F, et al. (2017) Endocytosis regulates TDP-43 toxicity and turnover. Nature Communications. 8: 2092
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